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Anthony Davenport

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Anthony P Davenport; Matthias Barton
Themed section: endothelin.
Lowell Ling; Janet J Maguire; Anthony P Davenport
Endothelin-2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer.
Janet J Maguire; Rhoda E Kuc; Anthony P Davenport
Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues.

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All Publications

2013: Anthony P Davenport; Matthias Barton
Themed section: endothelin.
British journal of pharmacology 2013;168(2):279-82.
2013: Lowell Ling; Janet J Maguire; Anthony P Davenport
Endothelin-2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer.
British journal of pharmacology 2013;168(2):283-95.
2012: Janet J Maguire; Rhoda E Kuc; Anthony P Davenport
Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues.
Life sciences 2012;91(13-14):681-6.
2012: Alison Seed; Hanka J de Voogd; Hans Essers; Chris Hillier; Fiona Johnston; Rhoda E Kuc; Janet J Maguire; John McMurray; Anthony P Davenport
The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans.
Life sciences 2012;91(13-14):743-8.
2012: Janet J Maguire; Victoria R Pell; Elizabeth Quinn; Tom Wehrman; Mike Brown; Andrew Green; Rhoda E Kuc; Sanj Kumar; Anthony P Davenport
Comparison of human ETA and ETB receptor signalling via G-protein and β-arrestin pathways.
Life sciences 2012;91(13-14):544-9.
2012: Lowell Ling; Janet J Maguire; David J Webb; Graeme J M Alexander; Neil J Davie; Paul Gibbs; Rhoda E Kuc; Anthony P Davenport
Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ETB knockout mice.
Life sciences 2012;91(13-14):716-22.
2012: Anthony P Davenport; Rhoda E Kuc
Cellular localization of receptors using antibodies visualized by light and dual labeling confocal microscopy.
Methods in molecular biology (Clifton, N.J.) 2012;897():239-60.
2012: Peter Johnström; Hugh K Richards; Joseph L Bird; Tim D Fryer; Anthony P Davenport
Dynamic in vivo imaging of receptors in small animals using positron emission tomography.
Methods in molecular biology (Clifton, N.J.) 2012;897():221-37.
2012: Peter Johnström; Joseph L Bird; Anthony P Davenport
Quantitative phosphor imaging autoradiography of radioligands for positron emission tomography.
Methods in molecular biology (Clifton, N.J.) 2012;897():205-20.
2012: Janet J Maguire; Rhoda E Kuc; Anthony P Davenport
Radioligand binding assays and their analysis.
Methods in molecular biology (Clifton, N.J.) 2012;897():31-77.
2011: N J Maximilian Macaluso; Sarah L Pitkin; Janet J Maguire; Anthony P Davenport; Robert C Glen
Discovery of a competitive apelin receptor (APJ) antagonist.
ChemMedChem 2011;6(6):1017-23.
2011: Janet J Maguire; Emma J Mead; William H Colledge; Xavier d'Anglemont de Tassigny; Helen R Kirby; Rhoda E Kuc; Anthony P Davenport
Inotropic action of the puberty hormone kisspeptin in rat, mouse and human: cardiovascular distribution and characteristics of the kisspeptin receptor.
PloS one 2011;6(11):e27601.
2011: Anthony P Davenport; Janet J Maguire
Pharmacology of renal endothelin receptors.
Contributions to nephrology 2011;172():1-17.
2010: John D Mitchell; Rhoda E Kuc; Janet J Maguire; Anthony P Davenport
Evidence for a novel vasospastic transmitter system, neuromedin U, in the equine digital circulation.
Veterinary journal (London, England : 1997) 2010;186(1):106-9.
2010: Sarah L Pitkin; Janet J Maguire; Rhoda E Kuc; Anthony P Davenport
Modulation of the apelin/APJ system in heart failure and atherosclerosis in man.
British journal of pharmacology 2010;160(7):1785-95.
2010: J L E Bird; D Izquierdo-Garcia; J R Davies; James Rudd; K C Probst; Nichola Figg; J C Clark; P L Weissberg; Anthony P Davenport; E A Warburton
Evaluation of translocator protein quantification as a tool for characterising macrophage burden in human carotid atherosclerosis.
Atherosclerosis 2010;210(2):388-91.
2010: Peter Johnström; Tim D Fryer; Hugh K Richards; Janet J Maguire; John C Clark; John D Pickard; Anthony P Davenport
Positron emission tomography of [18F]-big endothelin-1 reveals renal excretion but tissue-specific conversion to [18F]-endothelin-1 in lung and liver.
British journal of pharmacology 2010;159(4):812-9.
2010: John R Davies; David Izquierdo-Garcia; James Rudd; Nichola Figg; Hugh K Richards; Joseph L E Bird; Franklin I Aigbirhio; Anthony P Davenport; Peter L Weissberg; Tim D Fryer; Elizabeth A Warburton
FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis.
The international journal of cardiovascular imaging 2010;26(1):41-8.
2009: Janet J Maguire; Matthias J Kleinz; Sarah L Pitkin; Anthony P Davenport
[Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease.
Hypertension 2009;54(3):598-604.
2009: J D Mitchell; Janet J Maguire; Anthony P Davenport
Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S.
British journal of pharmacology 2009;158(1):87-103.
2009: Janet J Maguire; William A E Parker; Steven M Foord; Tom I Bonner; Richard Neubig; Anthony P Davenport
International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature.
Pharmacological reviews 2009;61(1):1-8.
2009: John D Mitchell; Janet J Maguire; Rhoda E Kuc; Anthony P Davenport
Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system.
Cardiovascular research 2009;81(2):353-61.
2008: Peter Johnström; John C Clark; John D Pickard; Anthony P Davenport
Automated synthesis of the generic peptide labelling agent N-succinimidyl 4-[(18)F]fluorobenzoate and application to (18)F-label the vasoactive transmitter urotensin-II as a ligand for positron emission tomography.
Nuclear medicine and biology 2008;35(6):725-31.
2008: Murray C H Clarke; Trevor D Littlewood; Nichola Figg; Janet J Maguire; Anthony P Davenport; Martin Goddard; Martin R Bennett
Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration.
Circulation research 2008;102(12):1529-38.
2008: Janet J Maguire; Rhoda E Kuc; Matthias J Kleinz; Anthony P Davenport
Immunocytochemical localization of the urotensin-II receptor, UT, to rat and human tissues: relevance to function.
Peptides 2008;29(5):735-42.
2007: E J Mead; Janet J Maguire; Rhoda E Kuc; Anthony P Davenport
Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system.
British journal of pharmacology 2007;151(8):1143-53.
2007: Katrin C Probst; David Izquierdo; Joseph L E Bird; Laurent Brichard; Dominic Franck; John R Davies; Tim D Fryer; Hugh K Richards; John C Clark; Anthony P Davenport; Peter L Weissberg; Elizabeth A Warburton
Strategy for improved [(11)C]DAA1106 radiosynthesis and in vivo peripheral benzodiazepine receptor imaging using microPET, evaluation of [(11)C]DAA1106.
Nuclear medicine and biology 2007;34(4):439-46.
2007: Emma J Mead; Janet J Maguire; Rhoda E Kuc; Anthony P Davenport
Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels.
Endocrinology 2007;148(1):140-7.
2006: Gurminder Singh; Janet J Maguire; Rhoda E Kuc; Jeremy N Skepper; Mark Fidock; Anthony P Davenport
Characterization of the snake venom ligand [125I]-DNP binding to natriuretic peptide receptor-A in human artery and potent DNP mediated vasodilatation.
British journal of pharmacology 2006;149(7):838-44.
2006: Murray C H Clarke; Nichola Figg; Janet J Maguire; Anthony P Davenport; Martin Goddard; Trevor D Littlewood; Martin R Bennett
Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis.
Nature medicine 2006;12(9):1075-80.
2006: Gurminder Singh; Anthony P Davenport
Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system.
British journal of pharmacology 2006;148(8):1033-41.
2006: Gurminder Singh; Rhoda E Kuc; Janet J Maguire; Mark Fidock; Anthony P Davenport
Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure.
Circulation research 2006;99(2):183-90.
2006: Janet J Maguire; Katherine E Wiley; Rhoda E Kuc; Victoria E A Stoneman; Martin R Bennett; Anthony P Davenport
Endothelin-mediated vasoconstriction in early atherosclerosis is markedly increased in ApoE-/- mouse but prevented by atorvastatin.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):806-12.
2006: Rhoda E Kuc; Janet J Maguire; Anthony P Davenport
Quantification of endothelin receptor subtypes in peripheral tissues reveals downregulation of ET(A) receptors in ET(B)-deficient mice.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):741-5.
2006: Peter Johnström; James Rudd; Hugh K Richards; Tim D Fryer; John C Clark; Peter L Weissberg; John D Pickard; Anthony P Davenport
Imaging endothelin ET(B) receptors using [18F]-BQ3020: in vitro characterization and positron emission tomography (microPET).
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):736-40.
2006: Anthony P Davenport; Janet J Maguire
Endothelin.
Handbook of experimental pharmacology 2006;(176 Pt 1):295-329.
2006: Matthias J Kleinz; Janet J Maguire; Jeremy N Skepper; Anthony P Davenport
Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man.
Cardiovascular research 2006;69(1):227-35.
2005: Anthony P Davenport; Tom Bonner; Steven M Foord; Anthony J Harmar; Richard Neubig; Jean-Philippe Pin; Michael Spedding; Masayasu Kojima; Keniji Kangawa
International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function.
Pharmacological reviews 2005;57(4):541-6.
2005: Janet J Maguire; Anthony P Davenport
Regulation of vascular reactivity by established and emerging GPCRs.
Trends in pharmacological sciences 2005;26(9):448-54.
2005: Matthias J Kleinz; Anthony P Davenport
Emerging roles of apelin in biology and medicine.
Pharmacology & therapeutics 2005;107(2):198-211.
2005: Steven M Foord; Tom Bonner; Richard Neubig; Edward M Rosser; Jean-Phillipe Pin; Anthony P Davenport; Michael Spedding; Anthony J Harmar
International Union of Pharmacology. XLVI. G protein-coupled receptor list.
Pharmacological reviews 2005;57(2):279-88.
2005: Matthias J Kleinz; Jeremy N Skepper; Anthony P Davenport
Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells.
Regulatory peptides 2005;126(3):233-40.
2005: Peter Johnström; Tim D Fryer; Hugh K Richards; Olivier Barret; Anthony P Davenport
Dynamic in vivo imaging of receptors in small animals using positron emission tomography.
Methods in molecular biology (Clifton, N.J.) 2005;306():217-32.
2005: Peter Johnström; Anthony P Davenport
Imaging and characterization of radioligands for positron emission tomography using quantitative phosphor imaging autoradiography.
Methods in molecular biology (Clifton, N.J.) 2005;306():203-16.
2005: Anthony P Davenport; Rhoda E Kuc
Immunocytochemical localization of receptors using light and confocal microscopy with application to the phenotypic characterization of knock-out mice.
Methods in molecular biology (Clifton, N.J.) 2005;306():155-72.
2005: Anthony P Davenport; Rhoda E Kuc
Radioligand-binding and molecular-imaging techniques for the quantitative analysis of established and emerging orphan receptor systems.
Methods in molecular biology (Clifton, N.J.) 2005;306():93-120.
2005: Peter Johnström; Tim D Fryer; Hugh K Richards; Neil G Harris; Olivier Barret; John C Clark; John D Pickard; Anthony P Davenport
Positron emission tomography using 18F-labelled endothelin-1 reveals prevention of binding to cardiac receptors owing to tissue-specific clearance by ET B receptors in vivo.
British journal of pharmacology 2005;144(1):115-22.
2004: Katherine E Wiley; Anthony P Davenport
Endothelin receptor pharmacology and function in the mouse: comparison with rat and man.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S4-6.
2004: Peter Johnström; Tim D Fryer; Hugh K Richards; Olivier Barret; John C Clark; Eliot ohlstein; John D Pickard; Anthony P Davenport
In vivo imaging of cardiovascular endothelin receptors using the novel radiolabelled antagonist [18F]-SB209670 and positron emission tomography (microPET).
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S34-8.
2004: Janet Maguire; Anthony P Davenport
Alternative pathway to endothelin-converting enzyme for the synthesis of endothelin in human blood vessels.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S27-9.
2004: Janet J Maguire; Rhoda E Kuc; Katherine E Wiley; Matthias J Kleinz; Anthony P Davenport
Cellular distribution of immunoreactive urotensin-II in human tissues with evidence of increased expression in atherosclerosis and a greater constrictor response of small compared to large coronary arteries.
Peptides 2004;25(10):1767-74.
2004: Katherine E Wiley; Anthony P Davenport
CRF2 receptors are highly expressed in the human cardiovascular system and their cognate ligands urocortins 2 and 3 are potent vasodilators.
British journal of pharmacology 2004;143(4):508-14.
2004: Gurminder Singh; Janet J Maguire; Rhoda E Kuc; Mark Fidock; Anthony P Davenport
Identification and cellular localisation of NPW1 (GPR7) receptors for the novel neuropeptide W-23 by [125I]-NPW radioligand binding and immunocytochemistry.
Brain research 2004;1017(1-2):222-6.
2004: Matthias J Kleinz; Anthony P Davenport
Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells.
Regulatory peptides 2004;118(3):119-25.
2003: Anthony P Davenport
Peptide and trace amine orphan receptors: prospects for new therapeutic targets.
Current opinion in pharmacology 2003;3(2):127-34.
2002: Janet J Maguire; Anthony P Davenport
Is urotensin-II the new endothelin?
British journal of pharmacology 2002;137(5):579-88.
2002: David K Menon; Diana Day; Rhoda E Kuc; Andrew J Downie; Doris A Chatfield; Anthony P Davenport
Arteriojugular endothelin-1 gradients in aneurysmal subarachnoid haemorrhage.
Clinical science (London, England : 1979) 2002;103 Suppl 48():399S-403S.
2002: Sabine Télémaque-Potts; Rhoda E Kuc; Janet J Maguire; Eliot Ohlstein; Masashi Yanagisawa; Anthony P Davenport
Elevated systemic levels of endothelin-1 and blood pressure correlate with blunted constrictor responses and downregulation of endothelin(A), but not endothelin(B), receptors in an animal model of hypertension.
Clinical science (London, England : 1979) 2002;103 Suppl 48():357S-362S.
2002: Janet J Maguire; Julie C-M Yu; Anthony P Davenport
ETA receptor antagonists inhibit intimal smooth muscle cell proliferation in human vessels.
Clinical science (London, England : 1979) 2002;103 Suppl 48():184S-188S.
2002: Sidath D Katugampola; Rhoda E Kuc; Janet J Maguire; Anthony P Davenport
G-protein-coupled receptors in human atherosclerosis: comparison of vasoconstrictors (endothelin and thromboxane) with recently de-orphanized (urotensin-II, apelin and ghrelin) receptors.
Clinical science (London, England : 1979) 2002;103 Suppl 48():171S-175S.
2002: Katherine E Wiley; Anthony P Davenport
Comparison of the effects of atherosclerosis and nitrate therapy on responses to nitric oxide and endothelin-1 in human arteries in vitro.
Clinical science (London, England : 1979) 2002;103 Suppl 48():124S-127S.
2002: Peter Johnström; Neil G Harris; Tim D Fryer; Olivier Barret; John C Clark; John D Pickard; Anthony P Davenport
(18)F-Endothelin-1, a positron emission tomography (PET) radioligand for the endothelin receptor system: radiosynthesis and in vivo imaging using microPET.
Clinical science (London, England : 1979) 2002;103 Suppl 48():4S-8S.
2002: Anthony P Davenport; Bruno Battistini
Classification of endothelin receptors and antagonists in clinical development.
Clinical science (London, England : 1979) 2002;103 Suppl 48():1S-3S.
2002: Katherine E Wiley; Anthony P Davenport
Comparison of vasodilators in human internal mammary artery: ghrelin is a potent physiological antagonist of endothelin-1.
British journal of pharmacology 2002;136(8):1146-52.
2002: James Rudd; Elizabeth A Warburton; Tim D Fryer; Hazel A Jones; John C Clark; Nagui M Antoun; Peter Johnström; Anthony P Davenport; P J Kirkpatrick; B N Arch; John D Pickard; Peter L Weissberg
Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography.
Circulation 2002;105(23):2708-11.
2002: Anthony P Davenport
International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature.
Pharmacological reviews 2002;54(2):219-26.
2002: Anthony P Davenport; Janet J Maguire
Of mice and men: advances in endothelin research and first antagonist gains FDA approval.
Trends in pharmacological sciences 2002;23(4):155-7.
2002: Anthony P Davenport; Rhoda E Kuc
Radioligand binding assays and quantitative autoradiography of endothelin receptors.
Methods in molecular biology (Clifton, N.J.) 2002;206():45-70.
2002: Anthony P Davenport; Rhoda E Kuc
Analysis of endothelins by enzyme-linked immunosorbent assay and radioimmunoassay.
Methods in molecular biology (Clifton, N.J.) 2002;206():21-36.
2002: Sidath D Katugampola; Anthony P Davenport
Radioligand binding reveals chymase as the predominant enzyme for mediating tissue conversion of angiotensin I in the normal human heart.
Clinical science (London, England : 1979) 2002;102(1):15-21.
2001: Sidath D Katugampola; Anthony P Davenport
Thromboxane receptor density is increased in human cardiovascular disease with evidence for inhibition at therapeutic concentrations by the AT(1) receptor antagonist losartan.
British journal of pharmacology 2001;134(7):1385-92.
2001: Janet J Maguire; Rhoda E Kuc; Anthony P Davenport
Vasoconstrictor activity of novel endothelin peptide, ET-1(1 - 31), in human mammary and coronary arteries in vitro.
British journal of pharmacology 2001;134(6):1360-6.
2001: Sidath D Katugampola; Z Pallikaros; Anthony P Davenport
[125I-His(9)]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: up-regulation of receptors with athersclerosis.
British journal of pharmacology 2001;134(1):143-9.
2001: Katherine E Wiley; Anthony P Davenport
Physiological antagonism of endothelin-1 in human conductance and resistance coronary artery.
British journal of pharmacology 2001;133(4):568-74.
2001: Anthony P Davenport; Janet J Maguire
The endothelin system in human saphenous vein graft disease.
Current opinion in pharmacology 2001;1(2):176-82.
2001: Sidath D Katugampola; Janet J Maguire; S R Matthewson; Anthony P Davenport
[(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man.
British journal of pharmacology 2001;132(6):1255-60.
2001: Katherine E Wiley; Anthony P Davenport
Nitric oxide-mediated modulation of the endothelin-1 signalling pathway in the human cardiovascular system.
British journal of pharmacology 2001;132(1):213-20.
2000: Sidath D Katugampola; Anthony P Davenport
Changes in ET(A)-, AT1- and AT2-receptors in the phenotypically transformed intimal smooth muscle layer of human atherosclerotic coronary arteries.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S395-6.
2000: Janet J Maguire; Anthony P Davenport
No alteration in vasoconstrictor endothelin-B-receptor density or function in human coronary artery disease.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S380-1.
2000: Rhoda E Kuc; Anthony P Davenport
Endothelin-A-receptors in human aorta and pulmonary arteries are downregulated in patients with cardiovascular disease: an adaptive response to increased levels of endothelin-1?
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S377-9.
2000: Katherine E Wiley; Anthony P Davenport
Novel nitric oxide donors reverse endothelin-1-mediated constriction in human blood vessels.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S151-2.
2000: S Télémaque-Potts; Rhoda E Kuc; M Yanagisawa; Anthony P Davenport
Tissue-specific modulation of endothelin receptors in a rat model of hypertension.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S122-3.
2000: Peter Johnström; Franklin I Aigbirhio; John C Clark; Stephen P M J Downey; John D Pickard; Anthony P Davenport
Syntheses of the first endothelin-A- and -B-selective radioligands for positron emission tomography.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S58-60.
2000: Anthony P Davenport; Rhoda E Kuc
Cellular expression of isoforms of endothelin-converting enzyme-1 (ECE-1c, ECE-1b and ECE-1a) and endothelin-converting enzyme-2.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S12-4.
2000: Janet J Maguire; Rhoda E Kuc; Anthony P Davenport
Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1.
British journal of pharmacology 2000;131(3):441-6.
1999: FD Russell; Anthony P Davenport
Evidence for intracellular endothelin-converting enzyme-2 expression in cultured human vascular endothelial cells.
Circulation research 1999;84(8):891-6.
1999: LN Pierre; Anthony P Davenport
Blockade and reversal of endothelin-induced constriction in pial arteries from human brain.
Stroke; a journal of cerebral circulation 1999;30(3):638-43.
1999: Janet J Maguire; Anthony P Davenport
Endothelin receptor expression and pharmacology in human saphenous vein graft.
British journal of pharmacology 1999;126(2):443-50.
1999: FD Russell; Anthony P Davenport
Secretory pathways in endothelin synthesis.
British journal of pharmacology 1999;126(2):391-8.
1998: Sharon Harland; Rhoda E Kuc; John D Pickard; Anthony P Davenport
Expression of endothelin(A) receptors in human gliomas and meningiomas, with high affinity for the selective antagonist PD156707.
Neurosurgery 1998;43(4):890-8; discussion 898-9.
1998: Janet J Maguire; Anthony P Davenport
Increased response to big endothelin-1 in atherosclerotic human coronary artery: functional evidence for up-regulation of endothelin-converting enzyme activity in disease.
British journal of pharmacology 1998;125(2):238-40.
1998: FD Russell; Jeremy N Skepper; Anthony P Davenport
Human endothelial cell storage granules: a novel intracellular site for isoforms of the endothelin-converting enzyme.
Circulation research 1998;83(3):314-21.
1998: LN Pierre; Anthony P Davenport
Endothelin receptor subtypes and their functional relevance in human small coronary arteries.
British journal of pharmacology 1998;124(3):499-506.
1998: FD Russell; A L Coppell; Anthony P Davenport
In vitro enzymatic processing of radiolabelled big ET-1 in human kidney.
Biochemical pharmacology 1998;55(5):697-701.
1998: FD Russell; Jeremy N Skepper; Anthony P Davenport
Evidence using immunoelectron microscopy for regulated and constitutive pathways in the transport and release of endothelin.
Journal of cardiovascular pharmacology 1998;31(3):424-30.
1998: Janet J Maguire; Anthony P Davenport
PD156707: a potent antagonist of endothelin-1 in human diseased coronary arteries and vein grafts.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S239-40.
1998: LN Pierre; Anthony P Davenport
Relative contribution of endothelin A and endothelin B receptors to vasoconstriction in small arteries from human heart and brain.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S74-6.
1998: JW Mockridge; Rhoda E Kuc; N S Huskisson; P J Barker; Anthony P Davenport
Characterization of site-directed antisera against endothelin-converting enzymes.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S35-7.
1998: FD Russell; Jeremy N Skepper; Anthony P Davenport
Endothelin peptide and converting enzymes in human endothelium.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S19-21.
1998: Anthony P Davenport; Rhoda E Kuc; JW Mockridge
Endothelin-converting enzyme in the human vasculature: evidence for differential conversion of big endothelin-3 by endothelial and smooth-muscle cells.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S1-3.
1998: Anthony P Davenport; Rhoda E Kuc; Michael J Ashby; WC Patt; AM Doherty
Characterization of [125I]-PD164333, an ETA selective non-peptide radiolabelled antagonist, in normal and diseased human tissues.
British journal of pharmacology 1998;123(2):223-30.
1997: Janet J Maguire; C M Johnson; JW Mockridge; Anthony P Davenport
Endothelin converting enzyme (ECE) activity in human vascular smooth muscle.
British journal of pharmacology 1997;122(8):1647-54.
1997: FD Russell; Jeremy N Skepper; Anthony P Davenport
Detection of endothelin receptors in human coronary artery vascular smooth muscle cells but not endothelial cells by using electron microscope autoradiography.
Journal of cardiovascular pharmacology 1997;29(6):820-6.
1997: Janet J Maguire; Rhoda E Kuc; Anthony P Davenport
Affinity and selectivity of PD156707, a novel nonpeptide endothelin antagonist, for human ET(A) and ET(B) receptors.
The Journal of pharmacology and experimental therapeutics 1997;280(2):1102-8.
1996: Anthony P Davenport; S L Hoskins; Rhoda E Kuc; C Plumpton
Differential distribution of endothelin peptides and receptors in human adrenal gland.
The Histochemical journal 1996;28(11):779-89.
1996: Fiona E Karet; Anthony P Davenport
Selective downregulation of ETA receptor mRNA in renal transplant recipients on cyclosporin A revealed by quantitative RT-PCR.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1996;11(10):1976-82.
1996: FD Russell; Anthony P Davenport
Characterization of the binding of endothelin ETB selective ligands in human and rat heart.
British journal of pharmacology 1996;119(4):631-6.
1996: C R Bacon; N R Cary; Anthony P Davenport
Endothelin peptide and receptors in human atherosclerotic coronary artery and aorta.
Circulation research 1996;79(4):794-801.
1996: C Plumpton; C J Ferro; William G Haynes; D J Webb; Anthony P Davenport
The increase in human plasma immunoreactive endothelin but not big endothelin-1 or its C-terminal fragment induced by systemic administration of the endothelin antagonist TAK-044.
British journal of pharmacology 1996;119(2):311-4.
1996: G P Collett; G Kohnen; S Campbell; Anthony P Davenport; M D Jeffers; Iain T Cameron
Localization of endothelin receptors in human uterus throughout the menstrual cycle.
Molecular human reproduction 1996;2(6):439-44.
1996: Janet J Maguire; Rhoda E Kuc; B A Rous; Anthony P Davenport
Failure of BQ123, a more potent antagonist of sarafotoxin 6b than of endothelin-1, to distinguish between these agonists in binding experiments.
British journal of pharmacology 1996;118(2):335-42.
1996: C R Bacon; Anthony P Davenport
Endothelin receptors in human coronary artery and aorta.
British journal of pharmacology 1996;117(5):986-92.
1996: Fiona E Karet; Anthony P Davenport
Localization of endothelin peptides in human kidney.
Kidney international 1996;49(2):382-7.
1996: M G Peter; Anthony P Davenport
Characterization of the endothelin receptor selective agonist, BQ3020 and antagonists BQ123, FR139317, BQ788, 50235, Ro462005 and bosentan in the heart.
British journal of pharmacology 1996;117(3):455-462.
1996: C Plumpton; M J Ashby; Rhoda E Kuc; G O'Reilly; Anthony P Davenport
Expression of endothelin peptides and mRNA in the human heart.
Clinical science (London, England : 1979) 1996;90(1):37-46.
1995: J C Yu; John D Pickard; Anthony P Davenport
Endothelin ETA receptor expression in human cerebrovascular smooth muscle cells.
British journal of pharmacology 1995;116(5):2441-6.
1995: C Plumpton; William G Haynes; D J Webb; Anthony P Davenport
Phosphoramidon inhibition of the in vivo conversion of big endothelin-1 to endothelin-1 in the human forearm.
British journal of pharmacology 1995;116(2):1821-8.
1995: Iain T Cameron; C R Bacon; G P Collett; Anthony P Davenport
Endothelin expression in the uterus.
The Journal of steroid biochemistry and molecular biology 1995;53(1-6):209-14.
1995: Janet J Maguire; Anthony P Davenport
ETA receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro.
British journal of pharmacology 1995;115(1):191-7.
1995: Anthony P Davenport; G O'Reilly; Rhoda E Kuc
Endothelin ETA and ETB mRNA and receptors expressed by smooth muscle in the human vasculature: majority of the ETA sub-type.
British journal of pharmacology 1995;114(6):1110-6.
1995: C R Bacon; N R Cary; Anthony P Davenport
Distribution of endothelin receptors in atherosclerotic human coronary arteries.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S439-41.
1995: S P Harland; Rhoda E Kuc; John D Pickard; Anthony P Davenport
Characterization of endothelin receptors in human brain cortex, gliomas, and meningiomas.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S408-11.
1995: Rhoda E Kuc; Fiona E Karet; Anthony P Davenport
Characterization of peptide and nonpeptide antagonists in human kidney.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S373-5.
1995: Janet J Maguire; Rhoda E Kuc; AM Doherty; Anthony P Davenport
Potency of PD155080, an orally active ETA receptor antagonist, determined for human endothelin receptors.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S362-4.
1995: M G Peter; Anthony P Davenport
Delineation of endothelin receptors in human left ventricular smooth-muscle cells.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S355-7.
1995: J C Yu; Anthony P Davenport
Regulation of endothelin receptor expression in vascular smooth-muscle cells.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S348-50.
1995: FD Russell; Anthony P Davenport
Characterization of endothelin receptors in the human pulmonary vasculature using bosentan, SB209670, and 97-139.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S346-7.
1995: C Plumpton; William G Haynes; D J Webb; Anthony P Davenport
Measurement of C-terminal fragment of big endothelin-1: a novel method for assessing the generation of endothelin-1 in humans.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S34-6.
1995: L N Pierre; Anthony P Davenport
Autoradiographic study of endothelin receptors in human cerebral arteries.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S326-8.
1995: Fiona E Karet; Anthony P Davenport
Comparative quantification of endothelin receptor mRNA in human kidney: new tools for direct investigation of human tissue.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S268-71.
1995: Anthony P Davenport; Rhoda E Kuc; Janet J Maguire; S P Harland
ETA receptors predominate in the human vasculature and mediate constriction.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S265-7.
1995: M J Ashby; C Plumpton; Philip Teale; Rhoda E Kuc; Ed Houghton; Anthony P Davenport
Analysis of endogenous human endothelin peptides by high-performance liquid chromatography and mass spectrometry.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S247-9.
1995: C R Bacon; John J Morrison; G O'Reilly; Iain T Cameron; Anthony P Davenport
ETA and ETB endothelin receptors in human myometrium characterized by the subtype selective ligands BQ123, BQ3020, FR139317 and PD151242.
The Journal of endocrinology 1995;144(1):127-34.
1995: J C Yu; Anthony P Davenport
Secretion of endothelin-1 and endothelin-3 by human cultured vascular smooth muscle cells.
British journal of pharmacology 1995;114(2):551-7.
1995: M G Peter; Anthony P Davenport
Selectivity of [125I]-PD151242 for human, rat and porcine endothelin ETA receptors in the heart.
British journal of pharmacology 1995;114(2):297-302.
1994: Anthony P Davenport; Rhoda E Kuc; S L Hoskins; Fiona E Karet; F Fitzgerald
[125I]-PD151242: a selective ligand for endothelin ETA receptors in human kidney which localizes to renal vasculature.
British journal of pharmacology 1994;113(4):1303-10.
1994: Janet J Maguire; Rhoda E Kuc; G O'Reilly; Anthony P Davenport
Vasoconstrictor endothelin receptors characterized in human renal artery and vein in vitro.
British journal of pharmacology 1994;113(1):49-54.
1994: C Plumpton; S Kalinka; R C Martin; J K Horton; Anthony P Davenport
Effects of phosphoramidon and pepstatin A on the secretion of endothelin-1 and big endothelin-1 by human umbilical vein endothelial cells: measurement by two-site enzyme-linked immunosorbent assays.
Clinical science (London, England : 1979) 1994;87(2):245-51.
1994: Fiona E Karet; D Stephen Charnock-Jones; M L Harrison-Woolrych; G O'Reilly; Anthony P Davenport; Stephen K Smith
Quantification of mRNA in human tissue using fluorescent nested reverse-transcriptase polymerase chain reaction.
Analytical biochemistry 1994;220(2):384-90.
1994: Janet J Maguire; C R Bacon; M Fujimoto; Anthony P Davenport
Myricerone caffeoyl ester (50-235) is a non-peptide antagonist selective for human ETA receptors.
Journal of hypertension 1994;12(6):675-80.
1994: Anthony P Davenport; Janet J Maguire
Is endothelin-induced vasoconstriction mediated only by ETA receptors in humans?
Trends in pharmacological sciences 1994;15(1):9-11.
1994: Anthony P Davenport; Rhoda E Kuc; F Fitzgerald; Janet J Maguire; KA Berryman; AM Doherty
[125I]-PD151242: a selective radioligand for human ETA receptors.
British journal of pharmacology 1994;111(1):4-6.
1993: A Persidis; AA Harcombe; Anthony P Davenport; Rhoda E Kuc; C Plumpton; P L Weissberg
Isolation of human cardiac endothelin receptors by a peptide-receptor mobility shift assay.
Clinical science (London, England : 1979) 1993;85(2):169-73.
1993: Fiona E Karet; Rhoda E Kuc; Anthony P Davenport
Novel ligands BQ123 and BQ3020 characterize endothelin receptor subtypes ETA and ETB in human kidney.
Kidney international 1993;44(1):36-42.
1993: G O'Reilly; D Stephen Charnock-Jones; John J Morrison; Iain T Cameron; Anthony P Davenport; Stephen K Smith
Alternatively spliced mRNAs for human endothelin-2 and their tissue distribution.
Biochemical and biophysical research communications 1993;193(3):834-40.
1993: Iain T Cameron; C Plumpton; R Champeney; C van Papendorp; M J Ashby; Anthony P Davenport
Identification of endothelin-1, endothelin-2 and endothelin-3 in human endometrium.
Journal of reproduction and fertility 1993;98(1):251-5.
1993: P Molenaar; G O'Reilly; A Sharkey; Rhoda E Kuc; D P Harding; C Plumpton; G A Gresham; Anthony P Davenport
Characterization and localization of endothelin receptor subtypes in the human atrioventricular conducting system and myocardium.
Circulation research 1993;72(3):526-38.
1993: B Sun; Anthony P Davenport; Morris J Brown
Quantitative autoradiography reveals higher densities of specific calcitonin-gene-related peptide receptors in small intramyocardial compared with large epicardial coronary arteries.
Clinical science (London, England : 1979) 1993;84(1):55-60.
1993: Fiona E Karet; Anthony P Davenport
Human kidney: endothelin isoforms detected by HPLC with radioimmunoassay and receptor subtypes detected using ligands BQ123 and BQ3020.
Journal of cardiovascular pharmacology 1993;22 Suppl 8():S29-33.
1993: C Plumpton; R Champeney; M J Ashby; Rhoda E Kuc; Anthony P Davenport
Characterization of endothelin isoforms in human heart: endothelin-2 demonstrated.
Journal of cardiovascular pharmacology 1993;22 Suppl 8():S26-8.
1993: Anthony P Davenport; G O'Reilly; P Molenaar; Janet J Maguire; Rhoda E Kuc; A Sharkey; C R Bacon; A Ferro
Human endothelin receptors characterized using reverse transcriptase-polymerase chain reaction, in situ hybridization, and subtype-selective ligands BQ123 and BQ3020: evidence for expression of ETB receptors in human vascular smooth muscle.
Journal of cardiovascular pharmacology 1993;22 Suppl 8():S22-5.
1993: G O'Reilly; D Stephen Charnock-Jones; Iain T Cameron; Stephen K Smith; Anthony P Davenport
Endothelin-2 mRNA splice variants detected by RT-PCR in cultured human vascular smooth muscle and endothelial cells.
Journal of cardiovascular pharmacology 1993;22 Suppl 8():S18-21.
1992: G O'Reilly; D Stephen Charnock-Jones; Anthony P Davenport; Iain T Cameron; Stephen K Smith
Presence of messenger ribonucleic acid for endothelin-1, endothelin-2, and endothelin-3 in human endometrium and a change in the ratio of ETA and ETB receptor subtype across the menstrual cycle.
The Journal of clinical endocrinology and metabolism 1992;75(6):1545-9.
1992: P Molenaar; Rhoda E Kuc; Anthony P Davenport
Characterization of two new ETB selective radioligands, [125I]-BQ3020 and [125I]-[Ala1,3,11,15]ET-1 in human heart.
British journal of pharmacology 1992;107(3):637-9.
1992: P G Howard; C Plumpton; Anthony P Davenport
Anatomical localization and pharmacological activity of mature endothelins and their precursors in human vascular tissue.
Journal of hypertension 1992;10(11):1379-86.
1992: Stefan Marciniak; C Plumpton; P J Barker; N S Huskisson; Anthony P Davenport
Localization of immunoreactive endothelin and proendothelin in the human lung.
Pulmonary pharmacology 1992;5(3):175-82.
1992: Iain T Cameron; Anthony P Davenport; C van Papendorp; P J Barker; N S Huskisson; R S Gilmour; Morris J Brown; Stephen K Smith
Endothelin-like immunoreactivity in human endometrium.
Journal of reproduction and fertility 1992;95(2):623-8.
1992: A Jennifer Morton; Anthony P Davenport
Cerebellar neurons and glia respond differentially to endothelins and sarafotoxin S6b.
Brain research 1992;581(2):299-306.
1991: C L van Papendorp; Iain T Cameron; Anthony P Davenport; A King; P J Barker; N S Huskisson; R S Gilmour; Morris J Brown; Stephen K Smith
Localization and endogenous concentration of endothelin-like immunoreactivity in human placenta.
The Journal of endocrinology 1991;131(3):507-11.
1991: R E Haining; Iain T Cameron; C van Papendorp; Anthony P Davenport; Andrew M Prentice; EJ Thomas; Stephen K Smith
Epidermal growth factor in human endometrium: proliferative effects in culture and immunocytochemical localization in normal and endometriotic tissues.
Human reproduction (Oxford, England) 1991;6(9):1200-5.
1991: Anthony P Davenport; A Jennifer Morton
Binding sites for 125I ET-1, ET-2, ET-3 and vasoactive intestinal contractor are present in adult rat brain and neurone-enriched primary cultures of embryonic brain cells.
Brain research 1991;554(1-2):278-85.
1991: Anthony P Davenport; I T Cameron; S K Smith; Morris J Brown
Binding sites for iodinated endothelin-1, endothelin-2 and endothelin-3 demonstrated on human uterine glandular epithelial cells by quantitative high-resolution autoradiography.
The Journal of endocrinology 1991;129(1):149-54.
1991: Iain T Cameron; Anthony P Davenport; Morris J Brown; Stephen K Smith
Endothelin-1 stimulates prostaglandin F2 alpha release from human endometrium.
Prostaglandins, leukotrienes, and essential fatty acids 1991;42(3):155-7.
1991: Anthony P Davenport; A Jennifer Morton; Morris J Brown
Localization of endothelin-1 (ET-1), ET-2, and ET-3, mouse VIC, and sarafotoxin S6b binding sites in mammalian heart and kidney.
Journal of cardiovascular pharmacology 1991;17 Suppl 7():S152-5.
1990: P L Weissberg; C Witchell; Anthony P Davenport; T R Hesketh; James C Metcalfe
The endothelin peptides ET-1, ET-2, ET-3 and sarafotoxin S6b are co-mitogenic with platelet-derived growth factor for vascular smooth muscle cells.
Atherosclerosis 1990;85(2-3):257-62.
1990: D J Nunez; Morris J Brown; Anthony P Davenport; C B Neylon; J P Schofield; R K Wyse
Endothelin-1 mRNA is widely expressed in porcine and human tissues.
The Journal of clinical investigation 1990;85(5):1537-41.
1990: Anthony P Davenport; M J Ashby; P Easton; S Ella; J Bedford; C Dickerson; D J Nunez; S J Capper; Morris J Brown
A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: comparison of levels in patients with essential hypertension and normotensive control subjects.
Clinical science (London, England : 1979) 1990;78(3):261-4.
1989: Anthony P Davenport; D J Nunez; Morris J Brown
Binding sites for 125I-labelled endothelin-1 in the kidneys: differential distribution in rat, pig and man demonstrated by using quantitative autoradiography.
Clinical science (London, England : 1979) 1989;77(2):129-31.
1989: Anthony P Davenport; D J Nunez; J A Hall; A J Kaumann; Morris J Brown
Autoradiographical localization of binding sites for porcine [125I]endothelin-1 in humans, pigs, and rats: functional relevance in humans.
Journal of cardiovascular pharmacology 1989;13 Suppl 5():S166-70.