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Marcus Altfeld

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Vivek Naranbhai; Thumbi Ndung'u; Marcus Altfeld; Quarraisha Abdool Karim; Salim S Abdool Karim; William H Carr
Changes in Natural Killer cell activation and function during primary HIV-1 Infection.
Stephanie Jost; Marcus Altfeld
Control of human viral infections by natural killer cells.
Mathieu Angin; Melanie King; Bruce D Walker; Kai W Wucherpfennig; Marcus Altfeld; Marylyn M Addo
Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers.

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All Publications

2013: Vivek Naranbhai; Thumbi Ndung'u; Marcus Altfeld; Quarraisha Abdool Karim; Salim S Abdool Karim; William H Carr
Changes in Natural Killer cell activation and function during primary HIV-1 Infection.
PloS one 2013;8(1):e53251.
2013: Stephanie Jost; Marcus Altfeld
Control of human viral infections by natural killer cells.
Annual review of immunology 2013;31():163-94.
2012: Mathieu Angin; Melanie King; Bruce D Walker; Kai W Wucherpfennig; Marcus Altfeld; Marylyn M Addo
Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers.
AIDS (London, England) 2012;26(16):2112-5.
2012: Vivek Naranbhai; Natasha Samsunder; Sengeziwe Sibeko; Quarraisha Abdool-Karim; Salim S Abdool-Karim; Marcus Altfeld; William H Carr; Raveshni Durgiah
Innate immune activation enhances hiv acquisition in women, diminishing the effectiveness of tenofovir microbicide gel.
The Journal of infectious diseases 2012;206(7):993-1001.
2012: Vivek Naranbhai; Thumbi Ndung'u; Quarraisha Abdool-Karim; Salim S Abdool-Karim; Marcus Altfeld; William H Carr
Natural killer cell function in women at high risk for HIV acquisition: insights from a microbicide trial.
AIDS (London, England) 2012;26(14):1745-53.
2012: Stephanie Jost; Marcus Altfeld
Evasion from NK cell-mediated immune responses by HIV-1.
Microbes and infection / Institut Pasteur 2012;14(11):904-15.
2012: Mathieu Angin; Melanie King; Florencia Pereyra; Hendrik Streeck; Bruce D Walker; Fang Wen; Marcus Altfeld; Marylyn M Addo
Regulatory T cell frequencies do not correlate with breadth or magnitude of HIV-1-specific T cell responses.
AIDS research and human retroviruses 2012;28(8):749-51.
2012: Timothy E Dudek; Lena Fadda; Xiaojiang Gao; Adrianne D Gladden; Andrew D Luster; Elizabeth F Mellors; Daniel C No; Karen A Power; Edward Seung; Andrew M Tager; Trevor R Tivey; Vladimir D Vrbanac; Marcus Altfeld; Laura Battis; Priyasma Bhoumik; Christian L Boutwell; Todd M Allen
Rapid evolution of HIV-1 to functional CD8⁺ T cell responses in humanized BLT mice.
Science translational medicine 2012;4(143):143ra98.
2012: Stephanie Jost; Marcus Altfeld; J Judy Chang
Harnessing innate and adaptive immunity for viral vaccine design.
Expert review of vaccines 2012;11(7):775-7.
2012: Christina Thobakgale; Ildiko Toth; Bruce D Walker; Todd M Allen; Galit Alter; Suzane Bazner; Mary Carrington; Lena Fadda; Kimberly Lane; Thumbi Ndung'u; Florencia Pereyra; Eric S Rosenberg; Marcus Altfeld
Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection.
Journal of virology 2012;86(12):6986-93.
2012: Britta Panda; Vikki M Abrahams; Marcus Altfeld; Jeffrey L Ecker; Errol R Norwitz; Alexander Panda; Albert C Shaw; Aleksandar K Stanic; Ikuyo Ueda; Brett C Young; Bo R Rueda
Dendritic cells in the circulation of women with preeclampsia demonstrate a pro-inflammatory bias secondary to dysregulation of TLR receptors.
Journal of reproductive immunology 2012;94(2):210-5.
2012: Marianne W Mureithi; Vivek Naranbhai; Thumbi Ndung'u; Danielle Poole; Shabashini Reddy; Sengeziwe Sibeko; Lise Werner; Quarraisha Abdool-Karim; Salim Abdool Karim; Marcus Altfeld; Nompumelelo P Mkhwanazi
Preservation HIV-1-specific IFNγ+ CD4+ T-cell responses in breakthrough infections after exposure to tenofovir gel in the CAPRISA 004 microbicide trial.
Journal of acquired immune deficiency syndromes (1999) 2012;60(2):124-7.
2012: Mathieu Angin; Musie Ghebremichael; Tomoyuki C Hongo; Daniel E Kaufmann; Melanie King; Douglas S Kwon; Kenneth Law; Danny A Milner; Florencia Pereyra; Alicja Piechocka-Trocha; Augustine Pyo; Ashley Rezai; James M Richter; Scott J Rodig; Hendrik Streeck; Ildiko Toth; Bruce D Walker; Fang Wen; Marcus Altfeld; Marylyn M Addo
Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.
The Journal of infectious diseases 2012;205(10):1495-500.
2012: Mingming Jia; Dan Li; Zhen Liu; Hong Peng; Guoliang Ren; Yuhua Ruan; Bing Su; Bruce D Walker; Zhe Wang; Xu G Yu; Xiaoqing Zhang; Quanbi Zhao; Marcus Altfeld; Jianping Chen; Kunxue Hong; Yiming Shao
Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1 infected former plasma donors from China.
Cell research 2012;22(5):903-14.
2012: J Judy Chang; Erin H Doyle; Aurore Lacas; Robert J Lindsay; Florencia Pereyra; Eric S Rosenberg; Bruce D Walker; Todd M Allen; Karen L Axten; Marcus Altfeld
Differential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection.
AIDS (London, England) 2012;26(5):533-41.
2012: Christian Körner; Marcus Altfeld
Role of KIR3DS1 in human diseases.
Frontiers in immunology 2012;3():326.
2012: Lena Fadda; Christian Körner; Swati Kumar; Alicja Piechocka-Trocha; Nienke H van Teijlingen; Mary Carrington; Marcus Altfeld
HLA-Cw*0102-restricted HIV-1 p24 epitope variants can modulate the binding of the inhibitory KIR2DL2 receptor and primary NK cell function.
PLoS pathogens 2012;8(7):e1002805.
2012: Boris Julg; Richard A Murphy; Danielle Poole; Henry Sunpath; Marcus Altfeld; Carmen Castilla; Musie Ghebremichael; Bruce D Walker
Factors predicting discordant virological and immunological responses to antiretroviral therapy in HIV-1 clade C infected Zulu/Xhosa in South Africa.
PloS one 2012;7(2):e31161.
2011: Mopo Radebe; Mary van der Stok; Bruce D Walker; Jaclyn K Wright; Marcus Altfeld; Ingrid V Bassett; Karen Bishop; Fundisiwe Chonco; Zenele Mncube; Kriebashnie Nair; Thumbi Ndung'u
Limited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infection.
The Journal of infectious diseases 2011;204(5):768-76.
2011: Rutger Luteijn; Anne Nolting; Gaia Sciaranghella; Jan van Lunzen; Marcus Altfeld; Anne-Sophie Dugast; Musie S Ghebremichael; Galit Alter
Early viral replication in lymph nodes provides HIV with a means by which to escape NK-cell-mediated control.
European journal of immunology 2011;41(9):2729-40.
2011: Christina Thobakgale; Gareth Tudor-Williams; Bruce D Walker; Andrew Prendergast; Hendrik Streeck; Marcus Altfeld; Fundisiwe Chonco; Philip J R Goulder; Lungile Maphumulo; Nompumelelo Mkhwanazi; Zenele Mncube; Thumbi Ndung'u
Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection.
AIDS research and human retroviruses 2011;27(9):1005-12.
2011: Galit Alter; Todd M Allen; Jonathan M Carlson; Mary Carrington; Lena Fadda; David Heckerman; Carl M Kadie; Salim I Khakoo; Bin Li; Maureen Martin; Cesar Oniangue-Ndza; Arne Schneidewind; Marcus Altfeld
HIV-1 adaptation to NK-cell-mediated immune pressure.
Nature 2011;476(7358):96-100.
2011: Galit Alter; Marcus Altfeld; Ronald Bosch; Musie Ghebremichael; Stephanie Jost; Brian E Nolan; Laura L Reyor; Suzannah Rihn; Georg M Lauer
Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance.
Journal of hepatology 2011;55(2):278-88.
2011: Vincent Dahirel; Darrell J Irvine; Toshiyuki Miura; Florencia Pereyra; Karthik Shekhar; Shiv Talsania; Bruce D Walker; Todd M Allen; Marcus Altfeld; Mikita Artyomov; Mary Carrington; Arup K Chakraborty
Coordinate linkage of HIV evolution reveals regions of immunological vulnerability.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(28):11530-5.
2011: Lena Fadda; Geraldine M O'Connor; Swati Kumar; Alicja Piechocka-Trocha; Clair M Gardiner; Mary Carrington; Daniel W McVicar; Marcus Altfeld
Common HIV-1 peptide variants mediate differential binding of KIR3DL1 to HLA-Bw4 molecules.
Journal of virology 2011;85(12):5970-4.
2011: Hendrik Streeck; Douglas S Kwon; Augustine Pyo; Michael Flanders; Mathieu F Chevalier; Kenneth Law; Boris Jülg; Kasper Trocha; Jonathan S Jolin; Melis N Anahtar; Jeff Lian; Ildiko Toth; Zabrina L Brumme; J Judy Chang; Tyler Caron; Scott J Rodig; Danny A Milner; Alicja Piechoka-Trocha; Daniel E Kaufmann; Bruce D Walker; Marcus Altfeld
Epithelial adhesion molecules can inhibit HIV-1-specific CD8⁺ T-cell functions.
Blood 2011;117(19):5112-22.
2011: Galit Alter; Marcus Altfeld
Mutiny or scrutiny: NK cell modulation of DC function in HIV-1 infection.
Trends in immunology 2011;32(5):219-24.
2011: Marianne W Mureithi; Kristen Cohen; Ramona Moodley; Danielle Poole; Zenele Mncube; Anne Kasmar; D Branch Moody; Philip J R Goulder; Bruce D Walker; Marcus Altfeld; Thumbi Ndung'u
Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection.
AIDS research and human retroviruses 2011;27(5):501-9.
2011: Stephanie Jost; Jeff Reardon; Eric Peterson; Danielle Poole; Ronald Bosch; Galit Alter; Marcus Altfeld
Expansion of 2B4+ natural killer (NK) cells and decrease in NKp46+ NK cells in response to influenza.
Immunology 2011;132(4):516-26.
2011: Marcus Altfeld; Philip J Goulder
The STEP study provides a hint that vaccine induction of the right CD8+ T cell responses can facilitate immune control of HIV.
The Journal of infectious diseases 2011;203(6):753-5.
2011: Judy Chang; Robert J Lindsay; Smita Kulkarni; Jeffrey D Lifson; Mary Carrington; Marcus Altfeld
Polymorphisms in interferon regulatory factor 7 reduce interferon-α responses of plasmacytoid dendritic cells to HIV-1.
AIDS (London, England) 2011;25(5):715-7.
2011: Vivek Naranbhai; Pat Bartman; Dudu Ndlovu; Pamela Ramkalawon; Thumbi Ndung'u; Douglas Wilson; Marcus Altfeld; William H Carr
Impact of blood processing variations on natural killer cell frequency, activation, chemokine receptor expression and function.
Journal of immunological methods 2011;366(1-2):28-35.
2011: Arnaud D Colantonio; Benjamin N Bimber; William J Neidermyer; R Keith Reeves; Galit Alter; Marcus Altfeld; R Paul Johnson; Mary Carrington; David O'Connor; David T Evans
KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif.
PLoS pathogens 2011;7(3):e1001316.
2011: Marcus Altfeld; Lena Fadda; Davor Frleta; Nina Bhardwaj
DCs and NK cells: critical effectors in the immune response to HIV-1.
Nature reviews. Immunology 2011;11(3):176-86.
2011: Amie L Meditz; Samantha MaWhinney; Amanda Allshouse; William Feser; Martin Markowitz; Susan Little; Richard Hecht; Eric S Daar; Ann C Collier; Joseph B Margolick; J Michael Kilby; Jean-Pierre Routy; Brian Conway; John Kaldor; Jay Levy; Robert Schooley; David A Cooper; Marcus Altfeld; Douglas Richman; Elizabeth Connick
Sex, race, and geographic region influence clinical outcomes following primary HIV-1 infection.
The Journal of infectious diseases 2011;203(4):442-51.
2011: Marylyn M Addo; Marcus Altfeld; Diana M Brainard; Almas Rathod; Alicja Piechocka-Trocha; Ulgen Fideli; Joseph Mulenga; Erin Shutes; Donna Marie L Alvino; Eric Hunter; Susan Allen; Bruce D Walker
Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals.
The Journal of infectious diseases 2011;203(2):258-62.
2011: Laura Papagno; Galit Alter; Lambert Assoumou; Robert L Murphy; Felipe Garcia; Bonaventura Clotet; Martin Larsen; Martine Braibant; Anne-Geneviève Marcelin; Dominique Costagliola; Marcus Altfeld; Christine Katlama; Brigitte Autran
Comprehensive analysis of virus-specific T-cells provides clues for the failure of therapeutic immunization with ALVAC-HIV vaccine.
AIDS (London, England) 2011;25(1):27-36.
2011: Stephanie Jost; Blair A Parry; Eric Peterson; Heloise Quillay; Jeff Reardon; Rachel P Simmons; William D Binder; Nancy N P Bryant; Marcus Altfeld
Changes in cytokine levels and NK cell activation associated with influenza.
PloS one 2011;6(9):e25060.
2011: Supranee Buranapraditkun; Pokrath Hansasuta; Ursula Hempel; William H Hildebrand; Sven-Iver Lorenzen; Praphan Phanuphak; Patrawadee Pitakpolrat; Sarah L Rowland-Jones; Todd M Allen; Rachel L Allgaier; Marcus Altfeld; Christian Brander; Sunee Sirivichayakul; Pattarawat Thantivorasit; Bruce D Walker; Kiat Ruxrungtham
A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais.
PloS one 2011;6(8):e23603.
2011: Iliyana Mikell; D Noah Sather; Spyros A Kalams; Marcus Altfeld; Galit Alter; Leonidas Stamatatos
Characteristics of the earliest cross-neutralizing antibody response to HIV-1.
PLoS pathogens 2011;7(1):e1001251.
2011: Mathieu F Chevalier; Boris Jülg; Augustine Pyo; Michael Flanders; Srinika Ranasinghe; Damien Z Soghoian; Douglas S Kwon; Jenna Rychert; Jeffrey Lian; Matthias I Muller; Sam Cutler; Elizabeth McAndrew; Heiko Jessen; Florencia Pereyra; Eric S Rosenberg; Marcus Altfeld; Bruce D Walker; Hendrik Streeck
HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function.
Journal of virology 2011;85(2):733-41.
2010: Mark Alan Brockman; Zabrina L Brumme; Chanson J Brumme; Toshiyuki Miura; Jennifer Sela; Pamela C Rosato; Carl M Kadie; Jonathan M Carlson; Tristan J Markle; Hendrik Streeck; Anthony D Kelleher; Martin Markowitz; Heiko Jessen; Eric Rosenberg; Marcus Altfeld; P Richard Harrigan; David Heckerman; Bruce D Walker; Todd M Allen
Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection.
Journal of virology 2010;84(22):11937-49.
2010: J Judy Chang; Marcus Altfeld
Innate immune activation in primary HIV-1 infection.
The Journal of infectious diseases 2010;202 Suppl 2():S297-301.
2010: M Patricia D'Souza; Karen L Axten; Frederick M Hecht; Marcus Altfeld
Acute HIV-1 infection: what's new? Where are we going?
The Journal of infectious diseases 2010;202 Suppl 2():S267-9.
2010: Anne Nolting; Anne-Sophie Dugast; Suzannah Rihn; Rutger Luteijn; Mary F Carrington; Katherine Kane; Stephanie Jost; Ildiko Toth; Ellen Nagami; Gerd Faetkenheuer; Pia Hartmann; Marcus Altfeld; Galit Alter
MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction.
Virology 2010;406(1):12-20.
2010: Isabel Leroux-Roels; Marguerite Koutsoukos; Frederic Clement; Sophia Steyaert; Michel Janssens; Patricia Bourguignon; Kristen Cohen; Marcus Altfeld; Pierre Vandepapelière; Louise Pedneault; Lisa McNally; Geert Leroux-Roels; Gerald Voss
Strong and persistent CD4+ T-cell response in healthy adults immunized with a candidate HIV-1 vaccine containing gp120, Nef and Tat antigens formulated in three Adjuvant Systems.
Vaccine 2010;28(43):7016-24.
2010: Nompumelelo Mkhwanazi; Christina Thobakgale; Mary van der Stok; Shabashini Reddy; Zenele Mncube; Fundisiwe Chonco; Bruce D Walker; Marcus Altfeld; Philip J R Goulder; Thumbi Ndung'u
Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.
Virology 2010;405(2):483-91.
2010: Marianne W Mureith; J Judy Chang; Jeffrey D Lifson; Thumbi Ndung'u; Marcus Altfeld
Exposure to HIV-1-encoded Toll-like receptor 8 ligands enhances monocyte response to microbial encoded Toll-like receptor 2/4 ligands.
AIDS (London, England) 2010;24(12):1841-8.
2010: Galit Alter; Daniel Kavanagh; Suzannah Rihn; Rutger Luteijn; David Brooks; Michael Oldstone; Jan van Lunzen; Marcus Altfeld
IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection.
The Journal of clinical investigation 2010;120(6):1905-13.
2010: Andrej Kosmrlj; Elizabeth L Read; Ying Qi; Todd M Allen; Marcus Altfeld; Steven G Deeks; Florencia Pereyra; Mary Carrington; Bruce D Walker; Arup K Chakraborty
Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection.
Nature 2010;465(7296):350-4.
2010: Marcio de Oliveira Silva; Milena Bastos; Eduardo Martins Netto; Nancy Alves de Lima Gouvea; Alex Jose Leite Torres; Esper Kallas; David Ian Watkins; Marcus Altfeld; Carlos Brites
Acute HIV infection with rapid progression to AIDS.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2010;14(3):291-3.
2010: Ambrose H W Wong; Katie Williams; Sharon Reddy; Douglas Wilson; Janet Giddy; Galit Alter; Musie Ghebremichael; Mary N Carrington; Thumbi Ndung'u; Bruce D Walker; Marcus Altfeld; William H Carr
Alterations in natural killer cell receptor profiles during HIV type 1 disease progression among chronically infected South African adults.
AIDS research and human retroviruses 2010;26(4):459-69.
2010: Wayne M Yokoyama; Marcus Altfeld; Katharine C Hsu
Natural killer cells: tolerance to self and innate immunity to viral infection and malignancy.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2010;16(1 Suppl):S97-S105.
2009: Angela Meier; J Judy Chang; Ellen S Chan; Richard B Pollard; Harlyn K Sidhu; Smita Kulkarni; Tom Fang Wen; Robert J Lindsay; Liliana Orellana; Donna Mildvan; Suzane Bazner; Hendrik Streeck; Galit Alter; Jeffrey D Lifson; Mary Carrington; Ronald J Bosch; Gregory Robbins; Marcus Altfeld
Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1.
Nature medicine 2009;15(8):955-9.
2009: Hendrik Streeck; Jonathan S Jolin; Ying Qi; Bader Yassine-Diab; Randall C Johnson; Douglas S Kwon; Marylyn M Addo; Chanson Brumme; Jean-Pierre Routy; Susan Little; Heiko Jessen; Anthony D Kelleher; Frederick Hecht; Rafick-Pierre Sekaly; Eric S Rosenberg; Bruce D Walker; Mary Carrington; Marcus Altfeld
Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells.
Journal of virology 2009;83(15):7641-8.
2009: Galit Alter; Suzannah Rihn; Katharine Walter; Anne Nolting; Maureen Martin; Eric S Rosenberg; Jeffrey S Miller; Mary Carrington; Marcus Altfeld
HLA class I subtype-dependent expansion of KIR3DS1+ and KIR3DL1+ NK cells during acute human immunodeficiency virus type 1 infection.
Journal of virology 2009;83(13):6798-805.
2009: Yaoyu E Wang; Bin Li; Jonathan M Carlson; Hendrik Streeck; Adrianne D Gladden; Robert Goodman; Arne Schneidewind; Karen A Power; Ildiko Toth; Nicole Frahm; Galit Alter; Christian Brander; Mary Carrington; Bruce D Walker; Marcus Altfeld; David Heckerman; Todd M Allen
Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1.
Journal of virology 2009;83(4):1845-55.
2009: Hendrik Streeck; Heiko Jessen; Claudia Kuecherer; Bin Li; Arne B Jessen; Stephan Dupke; Axel Baumgarten; Ingrid Stahmer; Jan van Lunzen; Marcus Altfeld; Bruce D Walker; Todd M Allen
Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome.
AIDS (London, England) 2009;23(2):259-62.
2009: J Judy Chang; Marcus Altfeld
TLR-mediated immune activation in HIV.
Blood 2009;113(2):269-70.
2008: Angela Meier; Amelia Fisher; Harlyn K Sidhu; Judy J Chang; Tom F Wen; Hendrik Streeck; Galit Alter; Guido Silvestri; Marcus Altfeld
Rapid loss of dendritic cell and monocyte responses to TLR ligands following venipuncture.
Journal of immunological methods 2008;339(2):132-40.
2008: Nicolas Zucchini; Karine Crozat; Thomas Baranek; Scott H Robbins; Marcus Altfeld; Marc Dalod
Natural killer cells in immunodefense against infective agents.
Expert review of anti-infective therapy 2008;6(6):867-85.
2008: Galit Alter; Suzannah Rihn; Hendrik Streeck; Nickolas Teigen; Alicja Piechocka-Trocha; Kristin Moss; Kristen Cohen; Angela Meier; Florencia Pereyra; Bruce Walker; Marcus Altfeld
Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T cells in human immunodeficiency virus type 1 infection.
Journal of virology 2008;82(19):9668-77.
2008: Zabrina L Brumme; Chanson J Brumme; Jonathan Carlson; Hendrik Streeck; Mina John; Quentin Eichbaum; Brian L Block; Brett Baker; Carl Kadie; Martin Markowitz; Heiko Jessen; Anthony D Kelleher; Eric Rosenberg; John Kaldor; Yuko Yuki; Mary Carrington; Todd M Allen; Simon Mallal; Marcus Altfeld; David Heckerman; Bruce D Walker
Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection.
Journal of virology 2008;82(18):9216-27.
2008: Hendrik Streeck; Bin Li; Art F Y Poon; Arne Schneidewind; Adrianne D Gladden; Karen A Power; Demetre Daskalakis; Suzane Bazner; Rosario Zuniga; Christian Brander; Eric S Rosenberg; Simon D W Frost; Marcus Altfeld; Todd M Allen
Immune-driven recombination and loss of control after HIV superinfection.
The Journal of experimental medicine 2008;205(8):1789-96.
2008: Rasmi Thomas; Eriko Yamada; Galit Alter; Maureen P Martin; Arman A Bashirova; Paul J Norman; Marcus Altfeld; Peter Parham; Stephen K Anderson; Daniel W McVicar; Mary Carrington
Novel KIR3DL1 alleles and their expression levels on NK cells: convergent evolution of KIR3DL1 phenotype variation?
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6743-50.
2008: Todd M Allen; Marcus Altfeld
Crippling HIV one mutation at a time.
The Journal of experimental medicine 2008;205(5):1003-7.
2008: Hendrik Streeck; Zabrina L Brumme; Michael Anastario; Kristin W Cohen; Jonathan S Jolin; Angela Meier; Chanson J Brumme; Eric S Rosenberg; Galit Alter; Todd M Allen; Bruce D Walker; Marcus Altfeld
Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells.
PLoS medicine 2008;5(5):e100.
2008: Yan Zhuang; Yongtao Sun; Song Zhai; Dedong Huang; Shuguang Zhao; Shaoyang Wang; Whenzhen Kang; Xinhong Li; Bruce D Walker; Marcus Altfeld; Xu G Yu
Relative dominance of Env-gp41-specific cytotoxic T lymphocytes responses in HIV-1 advanced infection.
Current HIV research 2008;6(3):239-45.
2008: Hendrik Streeck; Kristin W Cohen; Jonathan S Jolin; Mark Alan Brockman; Angela Meier; Karen A Power; Michael T Waring; Galit Alter; Marcus Altfeld
Rapid ex vivo isolation and long-term culture of human Th17 cells.
Journal of immunological methods 2008;333(1-2):115-25.
2008: Angela Meier; Aranya Bagchi; Harlyn K Sidhu; Galit Alter; Todd J Suscovich; Daniel G Kavanagh; Hendrik Streeck; Mark Alan Brockman; Sylvie LeGall; Judith Hellman; Marcus Altfeld
Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands.
AIDS (London, England) 2008;22(5):655-8.
2008: M Patricia D'Souza; Marcus Altfeld
Measuring HIV-1-specific T cell immunity: how valid are current assays?
The Journal of infectious diseases 2008;197(3):337-9.
2008: Marcus Altfeld; Martin Markowitz
Acute HIV-1 infection: past lessons, current thinking, future goals.
Current opinion in HIV and AIDS 2008;3(1):1-3.
2007: Mathias Lichterfeld; Daniel G Kavanagh; Katie L Williams; Beenu Moza; Stanley K Mui; ToshiYuki Miura; Rohini Sivamurthy; Rachel L Allgaier; Florencia Pereyra; Alicja Trocha; Margaret E Feeney; Rajesh T Gandhi; Eric S Rosenberg; Marcus Altfeld; Todd M Allen; Rachel Allen; Bruce D Walker; Eric Sundberg; Xu G Yu
A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells.
The Journal of experimental medicine 2007;204(12):2813-24.
2007: Galit Alter; Maureen P Martin; Nickolas Teigen; William H Carr; Todd J Suscovich; Arne Schneidewind; Hendrik Streeck; Michael T Waring; Angela Meier; Christian Brander; Jeffrey D Lifson; Todd M Allen; Mary Carrington; Marcus Altfeld
Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes.
The Journal of experimental medicine 2007;204(12):3027-36.
2007: Véronique Pascal; Eriko Yamada; Maureen P Martin; Galit Alter; Marcus Altfeld; Julia A Metcalf; Michael Baseler; Joseph W Adelsberger; Mary Carrington; Stephen K Anderson; Daniel W McVicar
Detection of KIR3DS1 on the cell surface of peripheral blood NK cells facilitates identification of a novel null allele and assessment of KIR3DS1 expression during HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1625-33.
2007: Angela Meier; Galit Alter; Nicole Frahm; Harlyn Sidhu; Bin Li; Aranya Bagchi; Nickolas Teigen; Hendrik Streeck; Hans-Jürgen Stellbrink; Judith Hellman; Jan van Lunzen; Marcus Altfeld
MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligands.
Journal of virology 2007;81(15):8180-91.
2007: Hendrik Streeck; Mathias Lichterfeld; Galit Alter; Angela Meier; Nickolas Teigen; Bader Yassine-Diab; Harlyn K Sidhu; Susan Little; Anthony D Kelleher; Jean-Pierre Routy; Eric S Rosenberg; Rafick-Pierre Sekaly; Bruce D Walker; Marcus Altfeld
Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles.
Journal of virology 2007;81(14):7725-31.
2007: Keri L Schaubert; David A Price; Nicole Frahm; Jinzhu Li; Hwee Ng; Aviva Joseph; Elyse Paul; Biswanath Majumder; Velpandi Ayyavoo; Emma Gostick; Sharon Adams; Francesco M Marincola; Andrew K Sewell; Marcus Altfeld; Jason M Brenchley; Daniel C Douek; Otto O Yang; Christian Brander; Harris Goldstein; June Kan-Mitchell
Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7756-66.
2007: Galit Alter; Todd J Suscovich; Nickolas Teigen; Angela Meier; Hendrik Streeck; Christian Brander; Marcus Altfeld
Single-stranded RNA derived from HIV-1 serves as a potent activator of NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7658-66.
2007: Angela Meier; Marcus Altfeld
Toll-like receptor signaling in HIV-1 infection: a potential target for therapy?
Expert review of anti-infective therapy 2007;5(3):323-6.
2007: Marcus Altfeld; Philip J R Goulder
'Unleashed' natural killers hinder HIV.
Nature genetics 2007;39(6):708-10.
2007: Galit Alter; Nickolas Teigen; Ryan Ahern; Hendrik Streeck; Angela Meier; Eric S Rosenberg; Marcus Altfeld
Evolution of innate and adaptive effector cell functions during acute HIV-1 infection.
The Journal of infectious diseases 2007;195(10):1452-60.
2007: Viswanathan Lakshmanan; Galit Alter; Marcus Altfeld; Nina Bhardwaj
Biology of plasmacytoid dendritic cells and natural killer cells in HIV-1 infection.
Current opinion in HIV and AIDS 2007;2(3):189-200.
2007: Hendrik Streeck; Becky Schweighardt; Heiko Jessen; Rachel L Allgaier; Terri Wrin; Eric W Stawiski; Arne B Jessen; Todd M Allen; Bruce D Walker; Marcus Altfeld
Loss of HIV-1-specific T-cell responses associated with very rapid HIV-1 disease progression.
AIDS (London, England) 2007;21(7):889-91.
2007: Mathias Lichterfeld; Xu G Yu; Stanley K Mui; Katie L Williams; Alicja Trocha; Mark Alan Brockman; Rachel L Allgaier; Michael T Waring; Tomohiko Koibuchi; Mary N Johnston; Daniel Cohen; Todd M Allen; Eric S Rosenberg; Bruce D Walker; Marcus Altfeld
Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infection.
Journal of virology 2007;81(8):4199-214.
2007: Shuguang Zhao; Song Zhai; Yan Zhuang; Shaoyang Wang; Dedong Huang; Whenzhen Kang; Xinhong Li; Xu G Yu; Bruce D Walker; Marcus Altfeld; Yongtao Sun
Inter-clade cross-reactivity of HIV-1-specific T cell responses in human immunodeficiency virus type 1 infection in China.
Current HIV research 2007;5(2):251-9.
2007: Xu G Yu; Mathias Lichterfeld; Senica Chetty; Katie L Williams; Stanley K Mui; Toshiyuki Miura; Nicole Frahm; Margaret E Feeney; Yanhua Tang; Florencia Pereyra; Montiago X LaBute; Katja Pfafferott; Alasdair Leslie; Hayley Crawford; Rachel L Allgaier; William H Hildebrand; Richard A Kaslow; Christian Brander; Todd M Allen; Eric S Rosenberg; Photini Kiepiela; Madhu Vajpayee; Paul A Goepfert; Marcus Altfeld; Philip J R Goulder; Bruce D Walker
Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.
Journal of virology 2007;81(4):1619-31.
2007: Shu Li; Hongli Jiao; Xu Yu; Amie J Strong; Yiming Shao; Yongtao Sun; Marcus Altfeld; Yichen Lu
Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort.
Journal of acquired immune deficiency syndromes (1999) 2007;44(2):121-31.
2007: Jianping Chen; Kunxue Hong; Mingming Jia; Hongwei Liu; Yuanzhi Zhang; Sha Liu; Xiaoqing Zhang; Hongjing Zhao; Hong Peng; Pengfei Ma; Hui Xing; Yuhua Ruan; Katie L Williams; Xu G Yu; Marcus Altfeld; Bruce D Walker; Yiming Shao
Human immunodeficiency virus type 1 specific cytotoxic T lymphocyte responses in Chinese infected with HIV-1 B'/C Recombinant (CRF07_BC).
Retrovirology 2007;4():62.
2007: Marylyn M Addo; Rika Draenert; Almas Rathod; Cori L Verrill; Benjamin T Davis; Rajesh T Gandhi; Gregory Robbins; Nesli Basgoz; David R Stone; Daniel E Cohen; Mary N Johnston; Theresa Flynn; Alysse Wurcel; Eric S Rosenberg; Marcus Altfeld; Bruce D Walker
Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection.
PloS one 2007;2(3):e321.
2007: Shaoyang Wang; Yongtao Sun; Song Zhai; Yan Zhuang; Shuguang Zhao; Whenzhen Kang; Xinhong Li; Dedong Huang; Xu G Yu; Bruce D Walker; Marcus Altfeld
Identification of HLA-A11-restricted HIV-1-specific cytotoxic T-lymphocyte epitopes in China.
Current HIV research 2007;5(1):119-28.
2007: Bin Li; Adrianne D Gladden; Marcus Altfeld; John M Kaldor; David A Cooper; Anthony D Kelleher; Todd M Allen
Rapid reversion of sequence polymorphisms dominates early human immunodeficiency virus type 1 evolution.
Journal of virology 2007;81(1):193-201.
2006: Marcus Altfeld; Todd M Allen
Hitting HIV where it hurts: an alternative approach to HIV vaccine design.
Trends in immunology 2006;27(11):504-10.
2006: Marcus Altfeld; Elizabeth T Kalife; Ying Qi; Hendrik Streeck; Mathias Lichterfeld; Mary N Johnston; Nicole C Burgett; Martha E Swartz; Amy Yang; Galit Alter; Xu G Yu; Angela Meier; Jürgen K Rockstroh; Todd M Allen; Heiko Jessen; Eric S Rosenberg; Mary Carrington; Bruce D Walker
HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.
PLoS medicine 2006;3(10):e403.
2006: Cheryl L Day; Daniel E Kaufmann; Photini Kiepiela; Julia A Brown; Eshia Stephany Moodley-Govender; Sharon Reddy; Elizabeth W Mackey; Joseph D Miller; Alasdair Leslie; Chantal DePierres; Zenele Mncube; Jaikumar Duraiswamy; Baogong Zhu; Quentin Eichbaum; Marcus Altfeld; E John Wherry; Hoosen M Coovadia; Philip J R Goulder; Paul Klenerman; Rafi Ahmed; Gordon J Freeman; Bruce D Walker
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.
Nature 2006;443(7109):350-4.
2006: Hendrik Streeck; Heiko Jessen; Galit Alter; Nickolas Teigen; Michael T Waring; Arne Jessen; Ingrid Stahmer; Jan van Lunzen; Mathias Lichterfeld; Xiaojiang Gao; Todd M Allen; Mary Carrington; Bruce D Walker; Jürgen K Rockstroh; Marcus Altfeld
Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection.
The Journal of infectious diseases 2006;194(6):734-9.
2006: Galit Alter; Marcus Altfeld
NK cell function in HIV-1 infection.
Current molecular medicine 2006;6(6):621-9.
2006: Shaoyang Wang; Yan Zhuang; Song Zhai; Shuguang Zhao; Whenzhen Kang; Xinhong Li; Xu G Yu; Bruce D Walker; Marcus Altfeld; Yongtao Sun
Association between HIV Type 1-specific T cell responses and CD4+ T cell counts or CD4+:CD8+ T cell ratios in HIV Type 1 subtype B infection in China.
AIDS research and human retroviruses 2006;22(8):780-7.
2006: Galit Alter; Todd J Suscovich; Marianna Kleyman; Nickolas Teigen; Hendrik Streeck; M Tauheed Zaman; Angela Meier; Marcus Altfeld
Low perforin and elevated SHIP-1 expression is associated with functional anergy of natural killer cells in chronic HIV-1 infection.
AIDS (London, England) 2006;20(11):1549-51.
2006: Mathias Lichterfeld; Katie L Williams; Stanley K Mui; Shivani S Shah; Bianca R Mothe; Alessandro Sette; Arthur Kim; Mary N Johnston; Nicole C Burgett; Nicole Frahm; Daniel Cohen; Christian Brander; Eric S Rosenberg; Bruce D Walker; Marcus Altfeld; Xu G Yu
T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily.
International immunology 2006;18(7):1179-88.
2006: Galit Alter; Marcus Altfeld
Perspective natural killer cells: bridging innate and adaptive immunity?
IAVI report : newsletter on international AIDS vaccine research 2006;10(3):1, 6-10.
2006: Dirk Meyer-Olson; Kristen W Brady; Melissa T Bartman; Kristin M O'Sullivan; Brenna C Simons; Joseph Conrad; Coley B Duncan; Shelly Lorey; Atif Siddique; Rika Draenert; Marylyn M Addo; Marcus Altfeld; Eric Rosenberg; Todd M Allen; Bruce D Walker; Spyros A Kalams
Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire.
Blood 2006;107(6):2373-83.
2006: Rosario Zuñiga; Aldo Lucchetti; Patricia Galvan; Shyla Sanchez; Carmen Sanchez; Ana Hernandez; Hugo Sanchez; Nicole Frahm; Caitlyn H Linde; Hannah S Hewitt; William H Hildebrand; Marcus Altfeld; Todd M Allen; Bruce D Walker; Bette T Korber; Thomas Leitner; Jorge Sanchez; Christian Brander
Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control.
Journal of virology 2006;80(6):3122-5.
2006: Nicole Frahm; Photini Kiepiela; Sharon Adams; Caitlyn H Linde; Hannah S Hewitt; Kaori Sango; Margaret E Feeney; Marylyn M Addo; Mathias Lichterfeld; Matthew P Lahaie; Eunice Pae; Alysse Wurcel; Timothy Roach; M Anne St John; Marcus Altfeld; Francesco M Marincola; Corey Moore; Simon Mallal; Mary Carrington; David Heckerman; Todd M Allen; James I Mullins; Bette T Korber; Philip J R Goulder; Bruce D Walker; Christian Brander
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
Nature immunology 2006;7(2):173-8.
2005: Xiaojiang Gao; Arman Bashirova; Astrid K N Iversen; John Phair; James J Goedert; Susan Buchbinder; Keith Hoots; David Vlahov; Marcus Altfeld; Stephen J O'Brien; Mary Carrington
AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis.
Nature medicine 2005;11(12):1290-2.
2005: Galit Alter; Nickolas Teigen; Benjamin T Davis; Marylyn M Addo; Todd J Suscovich; Michael T Waring; Hendrik Streeck; Mary N Johnston; Kyle D Staller; M Tauheed Zaman; Xu G Yu; Mathias Lichterfeld; Nesli Basgoz; Eric S Rosenberg; Marcus Altfeld
Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection.
Blood 2005;106(10):3366-9.
2005: Todd M Allen; Marcus Altfeld; Shaun C Geer; Elizabeth T Kalife; Corey Moore; Kristin M O'Sullivan; Ivna Desouza; Margaret E Feeney; Robert L Eldridge; Erica L Maier; Daniel E Kaufmann; Matthew P Lahaie; Laura L Reyor; Giancarlo O Tanzi; Mary N Johnston; Christian Brander; Rika Draenert; Jürgen K Rockstroh; Heiko Jessen; Eric S Rosenberg; Simon Mallal; Bruce D Walker
Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.
Journal of virology 2005;79(21):13239-49.
2005: Danni Ramduth; Polan Chetty; Nolwandle Cyloria Mngquandaniso; Nonhlanhla Nene; Jason Harlow; Isobella Honeyborne; Nelisiwe Ntumba; Sharika Gappoo; Chiara Henry; Prakash Jeena; Marylyn M Addo; Marcus Altfeld; Christian Brander; Cheryl Day; Hoosen Coovadia; Photini Kiepiela; Philip J R Goulder; Bruce Walker
Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses.
The Journal of infectious diseases 2005;192(9):1588-96.
2005: Todd M Allen; Xu G Yu; Elizabeth T Kalife; Laura L Reyor; Mathias Lichterfeld; Mina John; Michael Cheng; Rachel L Allgaier; Stanley K Mui; Nicole Frahm; Galit Alter; Nancy V Brown; Mary N Johnston; Eric S Rosenberg; Simon Mallal; Christian Brander; Bruce D Walker; Marcus Altfeld
De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection.
Journal of virology 2005;79(20):12952-60.
2005: Xu G Yu; Mathias Lichterfeld; Beth Perkins; Elizabeth Kalife; Stanley K Mui; Jianping Chen; Michael Cheng; Wenzhen Kang; Galit Alter; Christian Brander; Bruce D Walker; Marcus Altfeld
High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level.
AIDS (London, England) 2005;19(14):1449-56.
2005: Rajesh T Gandhi; Marcus Altfeld
The quest for an HIV-1 therapeutic vaccine.
The Journal of infectious diseases 2005;192(4):556-9.
2005: Nicole Frahm; Sharon Adams; Photini Kiepiela; Caitlyn H Linde; Hannah S Hewitt; Mathias Lichterfeld; Kaori Sango; Nancy V Brown; Eunice Pae; Alysse Wurcel; Marcus Altfeld; Margaret E Feeney; Todd M Allen; Timothy Roach; M Anne St John; Eric S Daar; Eric Rosenberg; Bette Korber; Francesco M Marincola; Bruce D Walker; Philip J R Goulder; Christian Brander
HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load.
Journal of virology 2005;79(16):10218-25.
2005: Mathias Lichterfeld; Giuseppe Pantaleo; Marcus Altfeld
Loss of HIV-1-specific T cell proliferation in chronic HIV-1 infection: cause or consequence of viral replication?
AIDS (London, England) 2005;19(11):1225-7.
2005: Margaret E Feeney; Yanhua Tang; Katja Pfafferott; Kathleen A Roosevelt; Rika Draenert; Alicja Trocha; Xu G Yu; Cori L Verrill; Todd Allen; Corey Moore; Simon Mallal; Sandra K Burchett; Kenneth McIntosh; Stephen I Pelton; M Anne St John; Rohan Hazra; Paul Klenerman; Marcus Altfeld; Bruce D Walker; Philip J R Goulder
HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7524-30.
2005: Marcus Altfeld; Todd M Allen; Elizabeth T Kalife; Nicole Frahm; Marylyn M Addo; Bianca R Mothe; Almas Rathod; Laura L Reyor; Jason Harlow; Xu G Yu; Beth Perkins; Loren K Robinson; John Sidney; Galit Alter; Mathias Lichterfeld; Alessandro Sette; Eric S Rosenberg; Philip J R Goulder; Christian Brander; Bruce D Walker
The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.
Journal of virology 2005;79(8):5000-5.
2005: Mathias Lichterfeld; Xu G Yu; Sylvie Le Gall; Marcus Altfeld
Immunodominance of HIV-1-specific CD8(+) T-cell responses in acute HIV-1 infection: at the crossroads of viral and host genetics.
Trends in immunology 2005;26(3):166-71.
2004: Photini Kiepiela; Alasdair Leslie; Isobella Honeyborne; Danni Ramduth; Christina Thobakgale; Senica Chetty; Prinisha Rathnavalu; Corey Moore; Katja Pfafferott; Louise Hilton; Peter Zimbwa; Sarah Moore; Todd Allen; Christian Brander; Marylyn M Addo; Marcus Altfeld; Ian James; Simon Mallal; Mike Bunce; Linda D Barber; James Szinger; Cheryl Day; Paul Klenerman; James Mullins; Bette Korber; Hoosen M Coovadia; Bruce D Walker; Philip J R Goulder
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
Nature 2004;432(7018):769-75.
2004: Christoph Hess; Terry K Means; Patrick Autissier; Tonia Woodberry; Marcus Altfeld; Marylyn M Addo; Nicole Frahm; Christian Brander; Bruce D Walker; Andrew D Luster
IL-8 responsiveness defines a subset of CD8 T cells poised to kill.
Blood 2004;104(12):3463-71.
2004: Galit Alter; Jessica M Malenfant; Marcus Altfeld
CD107a as a functional marker for the identification of natural killer cell activity.
Journal of immunological methods 2004;294(1-2):15-22.
2004: Daniel E Kaufmann; Mathias Lichterfeld; Marcus Altfeld; Marylyn M Addo; Mary N Johnston; Paul K Lee; Bradford S Wagner; Elizabeth T Kalife; Daryld Strick; Eric S Rosenberg; Bruce D Walker
Limited durability of viral control following treated acute HIV infection.
PLoS medicine 2004;1(2):e36.
2004: Galit Alter; Jessica M Malenfant; Rosemary M Delabre; Nicole C Burgett; Xu G Yu; Mathias Lichterfeld; John J Zaunders; Marcus Altfeld
Increased natural killer cell activity in viremic HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5305-11.
2004: Mathias Lichterfeld; Daniel E Kaufmann; Xu G Yu; Stanley K Mui; Marylyn M Addo; Mary N Johnston; Daniel Cohen; Gregory Robbins; Eunice Pae; Galit Alter; Alysse Wurcel; David Stone; Eric S Rosenberg; Bruce D Walker; Marcus Altfeld
Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells.
The Journal of experimental medicine 2004;200(6):701-12.
2004: Mathias Lichterfeld; Xu G Yu; Michael T Waring; Stanley K Mui; Mary N Johnston; Daniel Cohen; Marylyn M Addo; John J Zaunders; Galit Alter; Eunice Pae; Daryld Strick; Todd M Allen; Eric S Rosenberg; Bruce D Walker; Marcus Altfeld
HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha.
Blood 2004;104(2):487-94.
2004: Mathias Lichterfeld; Xu G Yu; Daniel Cohen; Marylyn M Addo; Jessica M Malenfant; Beth Perkins; Eunice Pae; Mary N Johnston; Daryld Strick; Todd M Allen; Eric S Rosenberg; Bette Korber; Bruce D Walker; Marcus Altfeld
HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity.
AIDS (London, England) 2004;18(10):1383-92.
2004: Todd M Allen; Marcus Altfeld; Xu G Yu; Kristin M O'Sullivan; Mathias Lichterfeld; Sylvie Le Gall; Mina John; Bianca R Mothe; Paul K Lee; Elizabeth T Kalife; Daniel E Cohen; Kenneth A Freedberg; Daryld Strick; Mary N Johnston; Alessandro Sette; Eric S Rosenberg; Simon Mallal; Philip J R Goulder; Christian Brander; Bruce D Walker
Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection.
Journal of virology 2004;78(13):7069-78.
2004: Xu G Yu; Marylyn M Addo; Beth A Perkins; Feili Wej; Almas Rathod; Shaun C Geer; Mark Parta; Daniel Cohen; David R Stone; Christopher J Russell; Giancarlo O Tanzi; Shan Mei; Alysse Wurcel; Nicole Frahm; Mathias Lichterfeld; Laura Heath; James I Mullins; Francesco M Marincola; Philip J R Goulder; Christian Brander; Todd Allen; Yunzhen Cao; Bruce D Walker; Marcus Altfeld
Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians.
AIDS research and human retroviruses 2004;20(5):557-64.
2004: Daniel E Kaufmann; Paul M Bailey; John Sidney; Bradford Wagner; Philip J Norris; Mary N Johnston; Lisa A Cosimi; Marylyn M Addo; Mathias Lichterfeld; Marcus Altfeld; Nicole Frahm; Christian Brander; Alessandro Sette; Bruce D Walker; Eric S Rosenberg
Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.
Journal of virology 2004;78(9):4463-77.
2004: Rika Draenert; Christian Brander; Xu G Yu; Marcus Altfeld; Cori L Verrill; Margaret E Feeney; Bruce D Walker; Philip J R Goulder
Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels.
AIDS (London, England) 2004;18(6):871-6.
2004: Rika Draenert; Sylvie Le Gall; Katja Pfafferott; Alasdair Leslie; Polan Chetty; Christian Brander; Edward C Holmes; Shih-Chung Chang; Margaret E Feeney; Marylyn M Addo; Lidia Ruiz; Danni Ramduth; Prakash Jeena; Marcus Altfeld; Stephanie Thomas; Yanhua Tang; Cori L Verrill; Catherine Dixon; Julia G Prado; Photini Kiepiela; Javier Martinez-Picado; Bruce D Walker; Philip J R Goulder
Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.
The Journal of experimental medicine 2004;199(7):905-15.
2004: Christoph Hess; Marcus Altfeld; Seddon Y Thomas; Marylyn M Addo; Eric S Rosenberg; Todd M Allen; Rika Draenert; Robert L Eldrige; Jan van Lunzen; Hans-J Stellbrink; Bruce D Walker; Andrew D Luster
HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication.
Lancet 2004;363(9412):863-6.
2004: Alasdair Leslie; Katja Pfafferott; Polan Chetty; Rika Draenert; Marylyn M Addo; Margaret E Feeney; Yanhua Tang; Edward C Holmes; Todd Allen; Julia G Prado; Marcus Altfeld; Christian Brander; C Dixon; Danni Ramduth; Prakash Jeena; S A Thomas; A St John; Timothy Roach; B Kupfer; Graz Luzzi; Anne Edwards; G Taylor; Hermione Lyall; Gareth Tudor-Williams; Vas Novelli; Javier Martinez-Picado; Photini Kiepiela; Bruce D Walker; Philip J R Goulder
HIV evolution: CTL escape mutation and reversion after transmission.
Nature medicine 2004;10(3):282-9.
2003: Marcus Altfeld; Marylyn M Addo; Eric S Rosenberg; Frederick Hecht; Paul K Lee; Martin Vogel; Xu G Yu; Rika Draenert; Mary N Johnston; Daryld Strick; Todd M Allen; Margaret E Feeney; James O Kahn; Rafick-Pierre Sekaly; Jay A Levy; Jürgen K Rockstroh; Philip J R Goulder; Bruce D Walker
Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.
AIDS (London, England) 2003;17(18):2581-91.
2003: Todd M Allen; Marcus Altfeld
HIV-1 superinfection.
The Journal of allergy and clinical immunology 2003;112(5):829-35; quiz 836.
2003: Marcus Altfeld; Marylyn M Addo; Raj Shankarappa; Paul K Lee; Todd M Allen; Xu G Yu; Almas Rathod; Jason Harlow; Kristin M O'Sullivan; Mary N Johnston; Philip J R Goulder; James I Mullins; Eric S Rosenberg; Christian Brander; Bette Korber; Bruce D Walker
Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences.
Journal of virology 2003;77(13):7330-40.
2003: Rika Draenert; Marcus Altfeld; Christian Brander; Nesli Basgoz; Colleen Corcoran; Alysse Wurcel; David R Stone; Spyros A Kalams; Alicja Trocha; Marylyn M Addo; Philip J R Goulder; Bruce D Walker
Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses.
Journal of immunological methods 2003;275(1-2):19-29.
2003: David C Montefiori; Marcus Altfeld; Paul K Lee; Miroslawa Bilska; Jintao Zhou; Mary N Johnston; Feng Gao; Bruce D Walker; Eric S Rosenberg
Viremia control despite escape from a rapid and potent autologous neutralizing antibody response after therapy cessation in an HIV-1-infected individual.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(7):3906-14.
2003: kevin bobbitt; Marylyn M Addo; Marcus Altfeld; Tracey M Filzen; Adewunmi A Onafuwa; Bruce D Walker; Kathleen L Collins
Rev activity determines sensitivity of HIV-1-infected primary T cells to CTL killing.
Immunity 2003;18(2):289-99.
2003: Marylyn M Addo; Xu G Yu; Almas Rathod; Daniel Cohen; Robert L Eldridge; Daryld Strick; Mary N Johnston; Colleen Corcoran; Alysse Wurcel; C A Fitzpatrick; Margaret E Feeney; William Rodriguez; Nesli Basgoz; Rika Draenert; David R Stone; Christian Brander; Philip J R Goulder; Eric S Rosenberg; Marcus Altfeld; Bruce D Walker
Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.
Journal of virology 2003;77(3):2081-92.
2002: George B Cohen; Sabina A Islam; Miriam S Noble; Christina Lau; Christian Brander; Marcus Altfeld; Eric S Rosenberg; Joern schmitz; Thomas O Cameron; Spyros A Kalams
Clonotype tracking of TCR repertoires during chronic virus infections.
Virology 2002;304(2):474-84.
2002: Marcus Altfeld; Todd M Allen; Xu G Yu; Mary N Johnston; Deepak Agrawal; Bette T Korber; David C Montefiori; David O'Connor; Benjamin T Davis; Paul K Lee; Erica L Maier; Jason Harlow; Philip J R Goulder; Christian Brander; Eric S Rosenberg; Bruce D Walker
HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus.
Nature 2002;420(6914):434-9.
2002: Karina Yusim; Can Kesmir; Brian Gaschen; Marylyn M Addo; Marcus Altfeld; Søren Brunak; Alexandre Chigaev; Vincent Detours; Bette T Korber
Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variation.
Journal of virology 2002;76(17):8757-68.
2002: Xu G Yu; Marylyn M Addo; Eric S Rosenberg; William Rodriguez; Paul K Lee; Cecily A Fitzpatrick; Mary N Johnston; Daryld Strick; Philip J R Goulder; Bruce D Walker; Marcus Altfeld
Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection.
Journal of virology 2002;76(17):8690-701.
2002: Marylyn M Addo; Marcus Altfeld; Almas Rathod; Michelle Yu; Xu G Yu; Philip J R Goulder; Eric S Rosenberg; Bruce D Walker
HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection.
AIDS (London, England) 2002;16(7):1071-3.
2002: Marcus Altfeld; Jan van Lunzen; Nicole Frahm; Xu G Yu; Claus Schneider; Robert L Eldridge; Margaret E Feeney; Dirk Meyer-Olson; Hans-Jürgen Stellbrink; Bruce D Walker
Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection.
The Journal of clinical investigation 2002;109(6):837-43.
2002: Xu G Yu; Hong Shang; Marylyn M Addo; Robert L Eldridge; Mary N Phillips; Margaret E Feeney; Daryld Strick; Christian Brander; Philip J R Goulder; Eric S Rosenberg; Bruce D Walker; Marcus Altfeld
Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses.
AIDS (London, England) 2002;16(3):321-8.
2001: Marcus Altfeld; Marylyn M Addo; Robert L Eldridge; Xu G Yu; S Thomas; Ashok Khatri; Daryld Strick; Mary N Phillips; George B Cohen; Sabina A Islam; Spyros A Kalams; Christian Brander; Philip J R Goulder; Eric S Rosenberg; Bruce D Walker
Vpr is preferentially targeted by CTL during HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2743-52.
2001: Marcus Altfeld; Bruce D Walker
Less is more? STI in acute and chronic HIV-1 infection.
Nature medicine 2001;7(8):881-4.
2001: Philip J R Goulder; Christian Brander; Yanhua Tang; C Tremblay; Robert A Colbert; Marylyn M Addo; Eric S Rosenberg; T Nguyen; R Allen; Alicja Trocha; Marcus Altfeld; S He; Mike Bunce; Robert Funkhouser; Stephen I Pelton; Sandra K Burchett; Kenneth McIntosh; Bette T Korber; Bruce D Walker
Evolution and transmission of stable CTL escape mutations in HIV infection.
Nature 2001;412(6844):334-8.
2001: Cheryl L Day; AK Shea; Marcus Altfeld; Douglas P Olson; SP Buchbinder; Frederick Hecht; Eric S Rosenberg; Bruce D Walker; Spyros A Kalams
Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles.
Journal of virology 2001;75(14):6279-91.
2001: Marylyn M Addo; Marcus Altfeld; Eric S Rosenberg; Robert L Eldridge; M N Philips; K Habeeb; Ashok Khatri; Christian Brander; Gregory Robbins; G P Mazzara; Philip J R Goulder; Bruce D Walker
The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1781-6.
2001: Philip J R Goulder; Marylyn M Addo; Marcus Altfeld; Eric S Rosenberg; Yanhua Tang; UG Govender; N Mngqundaniso; K Annamalai; T U Vogel; M Hammond; Mike Bunce; Hoosen M Coovadia; Bruce D Walker
Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays.
Journal of virology 2001;75(3):1339-47.
2001: Marcus Altfeld; Brian D Livingston; N Reshamwala; Phuong Thi Nguyen; Marylyn M Addo; AK Shea; M Newman; John Fikes; John Sidney; PA Wentworth; Robert W Chesnut; Robert L Eldridge; Eric S Rosenberg; Gregory Robbins; Christian Brander; PE Sax; SL Boswell; Theresa Flynn; Susan Buchbinder; Philip J R Goulder; Bruce D Walker; Alessandro Sette; Spyros A Kalams
Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif.
Journal of virology 2001;75(3):1301-11.
2001: Philip J R Goulder; Marcus Altfeld; Eric S Rosenberg; T Nguyen; Yanhua Tang; Robert L Eldridge; Marylyn M Addo; S He; Joia S Mukherjee; Mary N Phillips; Mike Bunce; Spyros A Kalams; Rafick-Pierre Sekaly; Bruce D Walker; Christian Brander
Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection.
The Journal of experimental medicine 2001;193(2):181-94.
2001: Marcus Altfeld; Eric S Rosenberg; Raj Shankarappa; Joia S Mukherjee; Frederick Hecht; Robert L Eldridge; Marylyn M Addo; S H Poon; Mary N Phillips; Gregory Robbins; PE Sax; SL Boswell; James O Kahn; Christian Brander; Philip J R Goulder; J A Levy; James I Mullins; Bruce D Walker
Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.
The Journal of experimental medicine 2001;193(2):169-80.
2000: Philip J R Goulder; Yanhua Tang; Christian Brander; M R Betts; Marcus Altfeld; K Annamalai; Alicja Trocha; S He; Eric S Rosenberg; GS Ogg; Christopher A O'Callaghan; Spyros A Kalams; R E McKinney; K Mayer; R A Koup; Stephen I Pelton; Sandra K Burchett; Kenneth McIntosh; Bruce D Walker
Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.
The Journal of experimental medicine 2000;192(12):1819-32.
2000: Eric S Rosenberg; Marcus Altfeld; S H Poon; Mary N Phillips; BM Wilkes; Robert L Eldridge; Gregory Robbins; Richard T D'Aquila; Philip J R Goulder; Bruce D Walker
Immune control of HIV-1 after early treatment of acute infection.
Nature 2000;407(6803):523-6.
2000: Marcus Altfeld; Alicja Trocha; Robert L Eldridge; Eric S Rosenberg; Mary N Phillips; Marylyn M Addo; Rafick-Pierre Sekaly; Spyros A Kalams; S A Burchett; Kenneth McIntosh; Bruce D Walker; Philip J R Goulder
Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay.
Journal of virology 2000;74(18):8541-9.
2000: Marcus Altfeld; Eric S Rosenberg
The role of CD4(+) T helper cells in the cytotoxic T lymphocyte response to HIV-1.
Current opinion in immunology 2000;12(4):375-80.
2000: Philip J R Goulder; Christian Brander; K Annamalai; N Mngqundaniso; UG Govender; Yanhua Tang; S He; Kelly Hartman; Christopher A O'Callaghan; GS Ogg; Marcus Altfeld; Eric S Rosenberg; H Cao; Spyros A Kalams; M Hammond; Mike Bunce; Stephen I Pelton; S A Burchett; Kenneth McIntosh; Hoosen M Coovadia; Bruce D Walker
Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children.
Journal of virology 2000;74(12):5679-90.