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Alun Davies

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TOP 3
Laura Howard; Guhan Nagappan; Sean Wyatt; Alun M Davies
ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75NTR-dependent mechanism.
Graziana Gatto; Philipp Suetterlin; John L Bixby; Alun M Davies; Uwe Drescher; Irina Dudanova; Rüdiger Klein
Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.
Humberto Gutierrez; Lilian Kisiswa; Gerard W O'Keeffe; Matthew J Smithen; Sean Wyatt; Alun M Davies
Regulation of neurite growth by tumour necrosis superfamily member RANKL.

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All Publications

2013: Laura Howard; Guhan Nagappan; Sean Wyatt; Alun M Davies
ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75NTR-dependent mechanism.
Development (Cambridge, England) 2013;140(10):2108-17.
2013: Graziana Gatto; Philipp Suetterlin; John L Bixby; Alun M Davies; Uwe Drescher; Irina Dudanova; Rüdiger Klein
Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(12):5399-410.
2013: Humberto Gutierrez; Lilian Kisiswa; Gerard W O'Keeffe; Matthew J Smithen; Sean Wyatt; Alun M Davies
Regulation of neurite growth by tumour necrosis superfamily member RANKL.
Open biology 2013;3(1):120150.
2012: Laura McKelvey; Giuseppe Nocentini; Sean J Crampton; Alun M Davies; Humberto Gutierrez; Carlo R Riccardi; Gerard W O'Keeffe
The intracellular portion of GITR enhances NGF-promoted neurite growth through an inverse modulation of Erk and NF-κB signalling.
Biology open 2012;1(10):1016-23.
2008: Epaminondas Doxakis; Howard Laura; Hermann Rohrer; Alun M Davies
HAND transcription factors are required for neonatal sympathetic neuron survival.
EMBO reports 2008;9(10):1041-7.
2008: Humberto Gutierrez; Gerard W O'Keeffe; Núria Gavaldà; Denis Gallagher; Alun M Davies
Nuclear factor kappa B signaling either stimulates or inhibits neurite growth depending on the phosphorylation status of p65/RelA.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(33):8246-56.
2008: Alun M Davies
Neurotrophins giveth and they taketh away.
Nature neuroscience 2008;11(6):627-8.
2008: Tammie Bishop; Denis Gallagher; Alberto Pascual; Craig A Lygate; Joseph P de Bono; Lynn G Nicholls; Patricia Ortega-Saenz; Henrik Oster; Bhathiya Wijeyekoon; Andrew I Sutherland; Alexandra Grosfeld; Julian Aragones; Martin Schneider; Katie van Geyte; Dania Teixeira; Antonio Diez-juan; Jose Lopez-Barneo; Keith M Channon; Patrick H Maxwell; Christopher W Pugh; Alun M Davies; Peter Carmeliet; Peter J Ratcliffe
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.
Molecular and cellular biology 2008;28(10):3386-400.
2008: Thomas N Vizard; Gerard W O'Keeffe; Humberto Gutierrez; Claudine H Kos; Daniela Riccardi; Alun M Davies
Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor.
Nature neuroscience 2008;11(3):285-91.
2008: Rosa Andres; Luis A Herraez-Baranda; Jane Thompson; Sean Wyatt; Alun M Davies
Regulation of sympathetic neuron differentiation by endogenous nerve growth factor and neurotrophin-3.
Neuroscience letters 2008;431(3):241-6.
2008: Gerard W O'Keeffe; Humberto Gutierrez; Pier Paolo Pandolfi; Carlo Riccardi; Alun M Davies
NGF-promoted axon growth and target innervation requires GITRL-GITR signaling.
Nature neuroscience 2008;11(2):135-42.
2007: Denis Gallagher; Humberto Gutierrez; Nuria Gavalda; Gerard O'Keeffe; Ron Hay; Alun M Davies
Nuclear factor-kappaB activation via tyrosine phosphorylation of inhibitor kappaB-alpha is crucial for ciliary neurotrophic factor-promoted neurite growth from developing neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(36):9664-9.
2007: Humberto Gutierrez; Alun M Davies
A fast and accurate procedure for deriving the Sholl profile in quantitative studies of neuronal morphology.
Journal of neuroscience methods 2007;163(1):24-30.
2006: Franz F Hefti; Arnon Rosenthal; Patricia A Walicke; Sean Wyatt; German Vergara; David L Shelton; Alun M Davies
Novel class of pain drugs based on antagonism of NGF.
Trends in pharmacological sciences 2006;27(2):85-91.
2005: Guido Pante; Jane Thompson; Fabienne Lamballe; Tomoko Iwata; Ingvar Ferby; Francis A Barr; Alun M Davies; Flavio Maina; Rüdiger Klein
Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth.
The Journal of cell biology 2005;171(2):337-48.
2005: Epaminondas Doxakis; Alun M Davies
Retinoic acid negatively regulates GDNF and neurturin receptor expression and responsiveness in embryonic chicken sympathetic neurons.
Molecular and cellular neurosciences 2005;29(4):617-27.
2004: Jane Thompson; Xavier Dolcet; Mark Hilton; Mary Tolcos; Alun M Davies
HGF promotes survival and growth of maturing sympathetic neurons by PI-3 kinase- and MAP kinase-dependent mechanisms.
Molecular and cellular neurosciences 2004;27(4):441-52.
2004: Carme Sole; Xavier Dolcet; Miguel F Segura; Humberto Gutierrez; María T Diaz-Meco; Raffaella Gozzelino; Daniel Sanchis; Jose Ramon Bayascas; Carme Gallego; Jorge Moscat; Alun M Davies; Joan X Comella
The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling.
The Journal of cell biology 2004;167(3):479-92.
2004: Epaminondas Doxakis; Eric J Huang; Alun M Davies
Homeodomain-interacting protein kinase-2 regulates apoptosis in developing sensory and sympathetic neurons.
Current biology : CB 2004;14(19):1761-5.
2004: Anirban R Saha; Josephine Hill; Michelle A Utton; Ayodeji A Asuni; Steven Ackerley; andy grierson; Christopher C J Miller; Alun M Davies; Vladimir L Buchman; Brian H Anderton; Diane P Hanger
Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons.
Journal of cell science 2004;117(Pt 7):1017-24.
2003: Natalia Ninkina; Katerina Papachroni; Darren C Robertson; Oliver Schmidt; Liz Delaney; Francis O'Neill; Felipe A Court; Arnon Rosenthal; Susan M Fleetwood-Walker; Alun M Davies; Vladimir L Buchman
Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene.
Molecular and cellular biology 2003;23(22):8233-45.
2003: Alun M Davies
Regulation of neuronal survival and death by extracellular signals during development.
The EMBO journal 2003;22(11):2537-45.
2003: Alison Forgie; Sean Wyatt; Pamela H Correll; Alun M Davies
Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.
Development (Cambridge, England) 2003;130(5):995-1002.
2002: Oliver Schmidt; Epaminondas Doxakis; Alun M Davies
Macrophage-stimulating protein is a neurotrophic factor for embryonic chicken hypoglossal motoneurons.
The European journal of neuroscience 2002;15(1):101-8.
2001: G Middleton; Alun M Davies
Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo.
Development (Cambridge, England) 2001;128(23):4715-28.
2001: V Barker; G Middleton; F Davey; Alun M Davies
TNFalpha contributes to the death of NGF-dependent neurons during development.
Nature neuroscience 2001;4(12):1194-8.
2001: Robert Andres; Alison Forgie; Sean Wyatt; Q Chen; F J de Sauvage; Alun M Davies
Multiple effects of artemin on sympathetic neurone generation, survival and growth.
Development (Cambridge, England) 2001;128(19):3685-95.
2001: N Orike; G Middleton; E Borthwick; Vladimir L Buchman; Timothy Cowen; Alun M Davies
Role of PI 3-kinase, Akt and Bcl-2-related proteins in sustaining the survival of neurotrophic factor-independent adult sympathetic neurons.
The Journal of cell biology 2001;154(5):995-1005.
2001: Tonino Alonzi; G Middleton; Sean Wyatt; Vladimir L Buchman; Werner Muller; W Müller; Piero Musiani; Valeria Poli; Alun M Davies
Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons.
Molecular and cellular neurosciences 2001;18(3):270-82.
2001: Flavio Maina; G Panté; Francoise Helmbacher; R Andres; A Porthin; Alun M Davies; Carola Ponzetto; Rudiger Klein
Coupling Met to specific pathways results in distinct developmental outcomes.
Molecular cell 2001;7(6):1293-306.
2001: G Middleton; Sean Wyatt; Natalia Ninkina; Alun M Davies
Reciprocal developmental changes in the roles of Bcl-w and Bcl-x(L) in regulating sensory neuron survival.
Development (Cambridge, England) 2001;128(3):447-57.
2000: Anna A Tiunova; Konstantin V Anokhin; Anirban R Saha; O Schmidt; Diane P Hanger; Brian H Anderton; Alun M Davies; Natalia Ninkina; Vladimir L Buchman
Chicken synucleins: cloning and expression in the developing embryo.
Mechanisms of development 2000;99(1-2):195-8.
2000: Anirban R Saha; Natalia Ninkina; Diane P Hanger; Brian H Anderton; Alun M Davies; Vladimir L Buchman
Induction of neuronal death by alpha-synuclein.
The European journal of neuroscience 2000;12(8):3073-7.
2000: Ivan T Gout; G Middleton; J Adu; Natalia Ninkina; Ludmila B Drobot; Valeriy Filonenko; Genadiy Matsuka; Alun M Davies; Michael D Waterfield; Vladimir L Buchman
Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein.
The EMBO journal 2000;19(15):4015-25.
2000: Alun M Davies
Neurotrophins: more to NGF than just survival.
Current biology : CB 2000;10(10):R374-6.
2000: E Doxakis; Sean Wyatt; Alun M Davies
Depolarisation causes reciprocal changes in GFR(alpha)-1 and GFR(alpha)-2 receptor expression and shifts responsiveness to GDNF and neurturin in developing neurons.
Development (Cambridge, England) 2000;127(7):1477-87.
2000: Alun M Davies
Neurotrophins: neurotrophic modulation of neurite growth.
Current biology : CB 2000;10(5):R198-200.
2000: G Middleton; S W Cox; S Korsmeyer; Alun M Davies
Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations.
The European journal of neuroscience 2000;12(3):819-27.
2000: Alison Forgie; F Kuehnel; Sean Wyatt; Alun M Davies
In vivo survival requirement of a subset of nodose ganglion neurons for nerve growth factor.
The European journal of neuroscience 2000;12(2):670-6.
2000: K Huber; F Kuehnel; Sean Wyatt; Alun M Davies
TrkB expression and early sensory neuron survival are independent of endogenous BDNF.
Journal of neuroscience research 2000;59(3):372-8.
2000: G Middleton; M Hamanoue; Y Enokido; Sean Wyatt; D Pennica; Ellis Jaffray; Ron Thomas Hay; Alun M Davies
Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons.
The Journal of cell biology 2000;148(2):325-32.
2000: Fleur Davey; M Hilton; Alun M Davies
Cooperation between HGF and CNTF in promoting the survival and growth of sensory and parasympathetic neurons.
Molecular and cellular neurosciences 2000;15(1):79-87.
1999: Y Enokido; Sean Wyatt; Alun M Davies
Developmental changes in the response of trigeminal neurons to neurotrophins: influence of birthdate and the ganglion environment.
Development (Cambridge, England) 1999;126(19):4365-73.
1999: Sean Wyatt; G Middleton; E Doxakis; Alun M Davies
Selective regulation of trkC expression by NT3 in the developing peripheral nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(15):6559-70.
1999: M Hamanoue; G Middleton; Sean Wyatt; Ellis Jaffray; Ron Thomas Hay; Alun M Davies
p75-mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor.
Molecular and cellular neurosciences 1999;14(1):28-40.
1999: Alison Forgie; E Doxakis; A Buj-Bello; Sean Wyatt; Alun M Davies
Differences and developmental changes in the responsiveness of PNS neurons to GDNF and neurturin.
Molecular and cellular neurosciences 1999;13(6):430-40.
1999: MV Alimova-Kost; Natalia Ninkina; Stefan Imreh; Nikolai V Gnuchev; J Adu; Alun M Davies; Vladimir L Buchman
Genomic structure and chromosomal localization of the mouse persyn gene.
Genomics 1999;56(2):224-7.
1999: Natalia Ninkina; E M Privalova; LG Pinõn; Alun M Davies; Vladimir L Buchman
Developmentally regulated expression of persyn, a member of the synuclein family, in skin.
Experimental cell research 1999;246(2):308-11.
1999: Sean Wyatt; R Andres; H Rohrer; Alun M Davies
Regulation of neurotrophin receptor expression by retinoic acid in mouse sympathetic neuroblasts.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(3):1062-71.
1998: Vladimir L Buchman; H J Hunter; LG Pinõn; J Thompson; E M Privalova; Natalia Ninkina; Alun M Davies
Persyn, a member of the synuclein family, has a distinct pattern of expression in the developing nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(22):9335-41.
1998: Y Enokido; Frederic J de Sauvage; J A Hongo; Natalia Ninkina; A Rosenthal; Vladimir L Buchman; Alun M Davies
GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin.
Current biology : CB 1998;8(18):1019-22.
1998: Natalia Ninkina; MV Alimova-Kost; J W Paterson; L Delaney; B B Cohen; Stefan Imreh; Nikolai V Gnuchev; Alun M Davies; Vladimir L Buchman
Organization, expression and polymorphism of the human persyn gene.
Human molecular genetics 1998;7(9):1417-24.
1998: Liliana Minichiello; F Casagranda; R S Tatche; Cheryl L Stucky; A Postigo; Gary R Lewin; Alun M Davies; Rudiger Klein
Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses.
Neuron 1998;21(2):335-45.
1998: Fleur Davey; Alun M Davies
TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons.
Current biology : CB 1998;8(16):915-8.
1998: Vladimir L Buchman; J Adu; LG Pinõn; Natalia Ninkina; Alun M Davies
Persyn, a member of the synuclein family, influences neurofilament network integrity.
Nature neuroscience 1998;1(2):101-3.
1998: J Thompson; E Doxakis; LG Piñón; P Strachan; A Buj-Bello; Sean Wyatt; Vladimir L Buchman; Alun M Davies
GFRalpha-4, a new GDNF family receptor.
Molecular and cellular neurosciences 1998;11(3):117-26.
1998: Flavio Maina; M C Hilton; R Andres; Sean Wyatt; Rudiger Klein; Alun M Davies
Multiple roles for hepatocyte growth factor in sympathetic neuron development.
Neuron 1998;20(5):835-46.
1998: G Middleton; LG Piñón; Sean Wyatt; Alun M Davies
Bcl-2 accelerates the maturation of early sensory neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(9):3344-50.
1998: Antony Horton; P F Barlett; D Pennica; Alun M Davies
Cytokines promote the survival of mouse cranial sensory neurones at different developmental stages.
The European journal of neuroscience 1998;10(2):673-9.
1998: Alun M Davies
Developmental changes in the neurotrophic factor survival requirements of peripheral nervous system neurons.
Progress in brain research 1998;117():47-56.
1998: Alun M Davies
Neuronal survival: early dependence on Schwann cells.
Current biology : CB 1998;8(1):R15-8.
1997: Flavio Maina; M C Hilton; Carola Ponzetto; Alun M Davies; Rudiger Klein
Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons.
Genes & development 1997;11(24):3341-50.
1997: Alun M Davies
Studies of neurotrophin biology in the developing trigeminal system.
Journal of anatomy 1997;191 ( Pt 4)():483-91.
1997: LG Piñón; G Middleton; Alun M Davies
Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development.
Development (Cambridge, England) 1997;124(20):4173-8.
1997: M Hilton; G Middleton; Alun M Davies
Bcl-2 influences axonal growth rate in embryonic sensory neurons.
Current biology : CB 1997;7(10):798-800.
1997: A Buj-Bello; J Adu; LG Piñón; Antony Horton; J Thompson; A Rosenthal; M Chinchetru; Vladimir L Buchman; Alun M Davies
Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase.
Nature 1997;387(6634):721-4.
1997: Sean Wyatt; L G Piñon; P Ernfors; Alun M Davies
Sympathetic neuron survival and TrkA expression in NT3-deficient mouse embryos.
The EMBO journal 1997;16(11):3115-23.
1997: Natalia Ninkina; M Grashchuck; Vladimir L Buchman; Alun M Davies
TrkB variants with deletions in the leucine-rich motifs of the extracellular domain.
The Journal of biological chemistry 1997;272(20):13019-25.
1997: Alun M Davies
Neurotrophin switching: where does it stand?
Current opinion in neurobiology 1997;7(1):110-8.
1997: Antony Horton; G Laramee; Sean Wyatt; A Shih; JW Winslow; Alun M Davies
NGF binding to p75 enhances the sensitivity of sensory and sympathetic neurons to NGF at different stages of development.
Molecular and cellular neurosciences 1997;10(3-4):162-72.
1997: Alun M Davies
Neurotrophins: the yin and yang of nerve growth factor.
Current biology : CB 1997;7(1):R38-40.
1996: Natalia Ninkina; J Adu; A Fischer; LG Piñón; Vladimir L Buchman; Alun M Davies
Expression and function of TrkB variants in developing sensory neurons.
The EMBO journal 1996;15(23):6385-93.
1996: M Robinson; J Adu; Alun M Davies
Timing and regulation of trkB and BDNF mRNA expression in placode-derived sensory neurons and their targets.
The European journal of neuroscience 1996;8(11):2399-406.
1996: L G Piñon; L Minichiello; R Klein; Alun M Davies
Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling.
Development (Cambridge, England) 1996;122(10):3255-61.
1996: Alun M Davies
Paracrine and autocrine actions of neurotrophic factors.
Neurochemical research 1996;21(7):749-53.
1996: I D Baka; Natalia Ninkina; L G Pinon; J Adu; Alun M Davies; G P Georgiev; Vladimir L Buchman
Intracellular compartmentalization of two differentially spliced s-rex/NSP mRNAs in neurons.
Molecular and cellular neurosciences 1996;7(4):289-303.
1996: Alun M Davies
The neurotrophic hypothesis: where does it stand?
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1338):389-94.
1996: M Robinson; A Buj-Bello; Alun M Davies
Paracrine interactions of BDNF involving NGF-dependent embryonic sensory neurons.
Molecular and cellular neurosciences 1996;7(2):143-51.
1996: G Middleton; Gabriel Nunez; Alun M Davies
Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors.
Development (Cambridge, England) 1996;122(2):695-701.
1996: Antony Horton; Alun M Davies; A Buj-Bello; P Bartlett; M Murphy
Leukemia inhibitory factor and ciliary neurotrophic factor in sensory neuron development.
Perspectives on developmental neurobiology 1996;4(1):35-8.
1995: L G Pinon; M Robinson; Alun M Davies
High specificity of neurotrophins in the embryonic chicken trigeminal system.
The European journal of neuroscience 1995;7(12):2397-402.
1995: A Buj-Bello; Vladimir L Buchman; Antony Horton; A Rosenthal; Alun M Davies
GDNF is an age-specific survival factor for sensory and autonomic neurons.
Neuron 1995;15(4):821-8.
1995: G Paul; Alun M Davies
Trigeminal sensory neurons require extrinsic signals to switch neurotrophin dependence during the early stages of target field innervation.
Developmental biology 1995;171(2):590-605.
1995: Alun M Davies; Sean Wyatt; M Nishimura; H Phillips
NGF receptor expression in sensory neurons develops normally in embryos lacking NGF.
Developmental biology 1995;171(2):434-8.
1995: Alun M Davies; L Minichiello; R Klein
Developmental changes in NT3 signalling via TrkA and TrkB in embryonic neurons.
The EMBO journal 1995;14(18):4482-9.
1995: Sean Wyatt; Alun M Davies
Regulation of nerve growth factor receptor gene expression in sympathetic neurons during development.
The Journal of cell biology 1995;130(6):1435-46.
1995: Alun M Davies; E M Wright
Neurotrophic factors. Neurotrophin autocrine loops.
Current biology : CB 1995;5(7):723-6.
1994: Alun M Davies
Neural development. Chemoattractants for navigating axons.
Current biology : CB 1994;4(12):1142-5.
1994: Vladimir L Buchman; Michael B. Sporn; Alun M Davies
Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development.
Development (Cambridge, England) 1994;120(6):1621-9.
1994: A Buj-Bello; L G Pinon; Alun M Davies
The survival of NGF-dependent but not BDNF-dependent cranial sensory neurons is promoted by several different neurotrophins early in their development.
Development (Cambridge, England) 1994;120(6):1573-80.
1994: Alun M Davies
Neurotrophic factors. Switching neurotrophin dependence.
Current biology : CB 1994;4(3):273-6.
1994: Alun M Davies
The role of neurotrophins during successive stages of sensory neuron development.
Progress in growth factor research 1994;5(3):263-89.
1993: Alun M Davies
Promoting motor neuron survival.
Current biology : CB 1993;3(12):879-81.
1993: Sean Wyatt; Alun M Davies
Regulation of expression of mRNAs encoding the nerve growth factor receptors p75 and trkA in developing sensory neurons.
Development (Cambridge, England) 1993;119(3):635-48.
1993: Alun M Davies; K F Lee; Rudolf Jaenisch
p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins.
Neuron 1993;11(4):565-74.