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Christopher Davies

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TOP 3
Alena Fedarovich; Robert A Nicholas; Christopher Davies
The role of the β5-α11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis.
Joshua Tomberg; Brenda Temple; Christopher Davies; Alena Fedarovich; Robert A Nicholas
A highly conserved interaction involving the middle residue of the SXN active-site motif is crucial for function of class B penicillin-binding proteins: mutational and computational analysis of PBP 2 from N. gonorrhoeae.
Alena Fedarovich; Robert A Nicholas; Yuri K Peterson; Shauna M Swanson; Kevin A Djordjevic; Christopher Davies
High-throughput screening for novel inhibitors of Neisseria gonorrhoeae penicillin-binding protein 2.

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All Publications

2012: Alena Fedarovich; Robert A Nicholas; Christopher Davies
The role of the β5-α11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis.
Journal of molecular biology 2012;418(5):316-30.
2012: Joshua Tomberg; Brenda Temple; Christopher Davies; Alena Fedarovich; Robert A Nicholas
A highly conserved interaction involving the middle residue of the SXN active-site motif is crucial for function of class B penicillin-binding proteins: mutational and computational analysis of PBP 2 from N. gonorrhoeae.
Biochemistry 2012;51(13):2775-84.
2012: Alena Fedarovich; Robert A Nicholas; Yuri K Peterson; Shauna M Swanson; Kevin A Djordjevic; Christopher Davies
High-throughput screening for novel inhibitors of Neisseria gonorrhoeae penicillin-binding protein 2.
PloS one 2012;7(9):e44918.
2010: George Nicola; Joshua Tomberg; R F Pratt; Robert A Nicholas; Christopher Davies
Crystal structures of covalent complexes of β-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity.
Biochemistry 2010;49(37):8094-104.
2010: Joshua Tomberg; Magnus Unemo; Christopher Davies; Robert A Nicholas
Molecular and structural analysis of mosaic variants of penicillin-binding protein 2 conferring decreased susceptibility to expanded-spectrum cephalosporins in Neisseria gonorrhoeae: role of epistatic mutations.
Biochemistry 2010;49(37):8062-70.
2010: Alena Fedarovich; Robert A Nicholas; Christopher Davies
Unusual conformation of the SxN motif in the crystal structure of penicillin-binding protein A from Mycobacterium tuberculosis.
Journal of molecular biology 2010;398(1):54-65.
2010: Thung S Lai; Christopher Davies; Charles S Greenberg
Human tissue transglutaminase is inhibited by pharmacologic and chemical acetylation.
Protein science : a publication of the Protein Society 2010;19(2):229-35.
2009: Neil A Demarse; Suriyan Ponnusamy; Eleanor K Spicer; Elif Apohan; John E Baatz; Besim Ogretmen; Christopher Davies
Direct binding of glyceraldehyde 3-phosphate dehydrogenase to telomeric DNA protects telomeres against chemotherapy-induced rapid degradation.
Journal of molecular biology 2009;394(4):789-803.
2009: Shuqing Zhao; Margaret Duncan; Joshua Tomberg; Christopher Davies; Magnus Unemo; Robert A Nicholas
Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae.
Antimicrobial agents and chemotherapy 2009;53(9):3744-51.
2009: Ailsa J Powell; Joshua Tomberg; Ashley M Deacon; Robert A Nicholas; Christopher Davies
Crystal structures of penicillin-binding protein 2 from penicillin-susceptible and -resistant strains of Neisseria gonorrhoeae reveal an unexpectedly subtle mechanism for antibiotic resistance.
The Journal of biological chemistry 2009;284(2):1202-12.
2008: Eric Sauvage; Ailsa J Powell; Jason Heilemann; Helen R Josephine; Paulette Charlier; Christopher Davies; Rex F Pratt
Crystal structures of complexes of bacterial DD-peptidases with peptidoglycan-mimetic ligands: the substrate specificity puzzle.
Journal of molecular biology 2008;381(2):383-93.
2007: Yuxiang Huang; Alena Fedarovich; Stephen Tomlinson; Christopher Davies
Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack complex.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 6):714-21.
2007: Yaroslav I Tsybovsky; Henry Donato; Natalia I Krupenko; Christopher Davies; Sergey A Krupenko
Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases.
Biochemistry 2007;46(11):2917-29.
2006: Helen R Josephine; Paulette Charlier; Christopher Davies; Robert A Nicholas; Rex F Pratt
Reactivity of penicillin-binding proteins with peptidoglycan-mimetic beta-lactams: what's wrong with these enzymes?
Biochemistry 2006;45(51):15873-83.
2006: Michael K Swan; Deepak Bastia; Christopher Davies
Crystal structure of pi initiator protein-iteron complex of plasmid R6K: implications for initiation of plasmid DNA replication.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(49):18481-6.
2006: Alena Fedarovich; Joshua Tomberg; Robert A Nicholas; Christopher Davies
Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 9):971-9.
2006: Ailsa J Powell; Zhi-Jie Liu; Robert A Nicholas; Christopher Davies
Crystal structures of the lytic transglycosylase MltA from N.gonorrhoeae and E.coli: insights into interdomain movements and substrate binding.
Journal of molecular biology 2006;359(1):122-36.
2005: Thomas Hansen; Bettina Schlichting; Joachim Grötzinger; Michael K Swan; Christopher Davies; Peter Schönheit
Mutagenesis of catalytically important residues of cupin type phosphoglucose isomerase from Archaeoglobus fulgidus.
The FEBS journal 2005;272(24):6266-75.
2005: George Nicola; Alena Fedarovich; Robert A Nicholas; Christopher Davies
A large displacement of the SXN motif of Cys115-modified penicillin-binding protein 5 from Escherichia coli.
The Biochemical journal 2005;392(Pt 1):55-63.
2005: Mei Hu; Sobhan Nandi; Christopher Davies; Robert A Nicholas
High-level chromosomally mediated tetracycline resistance in Neisseria gonorrhoeae results from a point mutation in the rpsJ gene encoding ribosomal protein S10 in combination with the mtrR and penB resistance determinants.
Antimicrobial agents and chemotherapy 2005;49(10):4327-34.
2005: George Nicola; Sridhar Peddi; Miglena E Stefanova; Robert A Nicholas; William G Gutheil; Christopher Davies
Crystal structure of Escherichia coli penicillin-binding protein 5 bound to a tripeptide boronic acid inhibitor: a role for Ser-110 in deacylation.
Biochemistry 2005;44(23):8207-17.
2005: Jonathan P Schuermann; Season P Prewitt; Christopher Davies; Susan L Deutscher; John J Tanner
Evidence for structural plasticity of heavy chain complementarity-determining region 3 in antibody-ssDNA recognition.
Journal of molecular biology 2005;347(5):965-78.
2004: Michael K Swan; Thomas Hansen; Peter Schönheit; Christopher Davies
Structural basis for phosphomannose isomerase activity in phosphoglucose isomerase from Pyrobaculum aerophilum: a subtle difference between distantly related enzymes.
Biochemistry 2004;43(44):14088-95.
2004: J T Graham Solomons; Ella M Zimmerly; Suzanne Burns; N Krishnamurthy; Michael K Swan; Sandra Krings; Hilary Muirhead; John M Chirgwin; Christopher Davies
The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening.
Journal of molecular biology 2004;342(3):847-60.
2004: Michael K Swan; Thomas Hansen; Peter Schönheit; Christopher Davies
A novel phosphoglucose isomerase (PGI)/phosphomannose isomerase from the crenarchaeon Pyrobaculum aerophilum is a member of the PGI superfamily: structural evidence at 1.16-A resolution.
The Journal of biological chemistry 2004;279(38):39838-45.
2004: Michael K Swan; Thomas Hansen; Peter Schönheit; Christopher Davies
Crystallization and preliminary X-ray diffraction analysis of phosphoglucose/phosphomannose isomerase from Pyrobaculum aerophilum.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 8):1481-3.
2004: Alexander A Chumanevich; Sergey A Krupenko; Christopher Davies
The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domain.
The Journal of biological chemistry 2004;279(14):14355-64.
2004: Miglena E Stefanova; Joshua Tomberg; Christopher Davies; Robert A Nicholas; William G Gutheil
Overexpression and enzymatic characterization of Neisseria gonorrhoeae penicillin-binding protein 4.
European journal of biochemistry / FEBS 2004;271(1):23-32.
2003: Robert A Nicholas; Sandra Krings; Joshua Tomberg; George Nicola; Christopher Davies
Crystal structure of wild-type penicillin-binding protein 5 from Escherichia coli: implications for deacylation of the acyl-enzyme complex.
The Journal of biological chemistry 2003;278(52):52826-33.
2003: Michael K Swan; J T Graham Solomons; Craig Beeson; Thomas Hansen; Peter Schönheit; Christopher Davies
Structural evidence for a hydride transfer mechanism of catalysis in phosphoglucose isomerase from Pyrococcus furiosus.
The Journal of biological chemistry 2003;278(47):47261-8.
2003: Michael K Swan; Thomas Hansen; Peter Schönheit; Christopher Davies
Crystallization and preliminary X-ray diffraction analysis of phosphoglucose isomerase from Pyrococcus furiosus.
Protein and peptide letters 2003;10(5):517-20.
2003: Christopher Davies; Hilary Muirhead; John M Chirgwin
The structure of human phosphoglucose isomerase complexed with a transition-state analogue.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 6):1111-3.
2003: Christopher Davies; Hilary Muirhead
Structure of native phosphoglucose isomerase from rabbit: conformational changes associated with catalytic function.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 3):453-65.
2002: Christopher Davies; Hilary Muirhead
Crystal structure of phosphoglucose isomerase from pig muscle and its complex with 5-phosphoarabinonate.
Proteins 2002;49(4):577-9.
2002: Alexander A Chumanevich; Christopher Davies; Sergey A Krupenko
Crystallization and preliminary X-ray diffraction analysis of recombinant hydrolase domain of 10-formyltetrahydrofolate dehydrogenase.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 10 Pt 2):1841-2.
2002: Miglena E Stefanova; Christopher Davies; Robert A Nicholas; William G Gutheil
pH, inhibitor, and substrate specificity studies on Escherichia coli penicillin-binding protein 5.
Biochimica et biophysica acta 2002;1597(2):292-300.
2001: J Read; J Pearce; X Li; Hilary Muirhead; John M Chirgwin; Christopher Davies
The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia.
Journal of molecular biology 2001;309(2):447-63.
2001: Christopher Davies; Stephen W White; Robert A Nicholas
Crystal structure of a deacylation-defective mutant of penicillin-binding protein 5 at 2.3-A resolution.
The Journal of biological chemistry 2001;276(1):616-23.
2000: Christopher Davies; Stephen W White
Electrons and X-rays gang up on the ribosome.
Structure (London, England : 1993) 2000;8(3):R41-5.
2000: Christopher Davies; R J Heath; Stephen W White; Charles O Rock
The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli.
Structure (London, England : 1993) 2000;8(2):185-95.
2000: Thomas Caspari; Christopher Davies; Antony M Carr
Analysis of the fission yeast checkpoint Rad proteins.
Cold Spring Harbor symposia on quantitative biology 2000;65():451-6.
1998: J Brogdon; D D Eckels; Christopher Davies; S White; Carolyn Doyle
A site for CD4 binding in the beta 1 domain of the MHC class II protein HLA-DR1.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5472-80.
1998: Wilfried Kugler; K Breme; P Laspe; H Muirhead; Christopher Davies; H Winkler; W Schröter; Max Lakomek
Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency.
Human genetics 1998;103(4):450-4.
1998: Christopher Davies; RB Gerstner; David E Draper; V Ramakrishnan; Stephen W White
The crystal structure of ribosomal protein S4 reveals a two-domain molecule with an extensive RNA-binding surface: one domain shows structural homology to the ETS DNA-binding motif.
The EMBO journal 1998;17(16):4545-58.
1998: Christopher Davies; D E Bussiere; Barbara L Golden; S J Porter; V Ramakrishnan; Stephen W White
Ribosomal proteins S5 and L6: high-resolution crystal structures and roles in protein synthesis and antibiotic resistance.
Journal of molecular biology 1998;279(4):873-88.
1998: William M Clemons; Christopher Davies; SW White; Venki Ramakrishnan
Conformational variability of the N-terminal helix in the structure of ribosomal protein S15.
Structure (London, England : 1993) 1998;6(4):429-38.
1997: M S Finnin; MP Cicero; Christopher Davies; S J Porter; Stephen W White; Kenneth N Kreuzer
The activation domain of the MotA transcription factor from bacteriophage T4.
The EMBO journal 1997;16(8):1992-2003.
1997: Christopher Davies; J C Beauchamp; D Emery; A Rawas; Hilary Muirhead
Structure of the Fab fragment from a neutralizing monoclonal antibody directed against an epitope of gp41 from HIV-1.
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 2):186-94.
1996: David W Hoffman; C S Cameron; Christopher Davies; S W White; V Ramakrishnan
Ribosomal protein L9: a structure determination by the combined use of X-ray crystallography and NMR spectroscopy.
Journal of molecular biology 1996;264(5):1058-71.
1996: A C Manna; K S Pai; Dirk Bussiere; Christopher Davies; Stephen W White; Deepak Bastia
Helicase-contrahelicase interaction and the mechanism of termination of DNA replication.
Cell 1996;87(5):881-91.
1996: Christopher Davies; V Ramakrishnan; Stephen W White
Structural evidence for specific S8-RNA and S8-protein interactions within the 30S ribosomal subunit: ribosomal protein S8 from Bacillus stearothermophilus at 1.9 A resolution.
Structure (London, England : 1993) 1996;4(9):1093-104.
1996: Christopher Davies; Stephen W White; V Ramakrishnan
The crystal structure of ribosomal protein L14 reveals an important organizational component of the translational apparatus.
Structure (London, England : 1993) 1996;4(1):55-66.
1994: Christopher Davies; S E Gerchman; J H Kycia; K McGee; V Ramakrishnan; Stephen W White
Crystallization and preliminary X-ray diffraction studies of bacterial ribosomal protein L14.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 5):790-2.
1994: D W Hoffman; Christopher Davies; S E Gerchman; J H Kycia; S J Porter; Stephen W White; V Ramakrishnan
Crystal structure of prokaryotic ribosomal protein L9: a bi-lobed RNA-binding protein.
The EMBO journal 1994;13(1):205-12.
1987: Hilary Muirhead; D A Clayden; S P Cuffe; Christopher Davies
Crystallographic studies on the structure and catalytic activity of pyruvate kinase from skeletal muscle.
Biochemical Society transactions 1987;15(5):996-9.