FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Gideon Davies

Research Profile

Concepts & Ideas

Procedures

X Ray Crystallography

Chemicals & Drugs

Co-author Network

Publications

TOP 3
Glyn R Hemsworth; Robbert Q Kim; Sally J Lewis; Alison Parkin; Edward J Taylor; Johan P Turkenburg; Gideon J Davies; Rebecca C Gregory; Paul H Walton
The Copper Active Site of CBM33 Polysaccharide Oxygenases.
Judith Stepper; Edward J Taylor; Preeyanuch Thongpoo; Johan P Turkenburg; Harry Brumer; Jerome Dabin; Jens M Eklof; Prachumporn Kongsaeree; Gideon J Davies
Structure and activity of the Streptococcus pyogenes family GH1 6-phospho-β-glucosidase SPy1599.
Johan Larsbrink; Gideon J Davies; Glyn R Hemsworth; Atsushi Izumi; Harry Brumer
Structural enzymology of Cellvibrio japonicus Agd31B protein reveals α-transglucosylase activity in glycoside hydrolase family 31.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Gideon Davies (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Glyn R Hemsworth; Robbert Q Kim; Sally J Lewis; Alison Parkin; Edward J Taylor; Johan P Turkenburg; Gideon J Davies; Rebecca C Gregory; Paul H Walton
The Copper Active Site of CBM33 Polysaccharide Oxygenases.
Journal of the American Chemical Society 2013;135(16):6069-77.
2013: Judith Stepper; Edward J Taylor; Preeyanuch Thongpoo; Johan P Turkenburg; Harry Brumer; Jerome Dabin; Jens M Eklof; Prachumporn Kongsaeree; Gideon J Davies
Structure and activity of the Streptococcus pyogenes family GH1 6-phospho-β-glucosidase SPy1599.
Acta crystallographica. Section D, Biological crystallography 2013;69(Pt 1):16-23.
2012: Johan Larsbrink; Gideon J Davies; Glyn R Hemsworth; Atsushi Izumi; Harry Brumer
Structural enzymology of Cellvibrio japonicus Agd31B protein reveals α-transglucosylase activity in glycoside hydrolase family 31.
The Journal of biological chemistry 2012;287(52):43288-99.
2012: Fiona Cuskin; Gideon J Davies; James E Flint; Tracey M Gloster; Bernard Henrissat; Carl Morland; Alexandra S Solovyova; Andrea Strazzulli; Arnaud Baslé; Pedro M Coutinho; Harry J Gilbert
How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(51):20889-94.
2012: Ramon Hurtado-Guerrero; Gideon J Davies
Recent structural and mechanistic insights into post-translational enzymatic glycosylation.
Current opinion in chemical biology 2012;16(5-6):479-87.
2012: Stephen G Withers; Gideon J Davies
Glycobiology: The case of the missing base.
Nature chemical biology 2012;8(12):952-3.
2012: Andrew J Thompson; Spencer J Williams; Albert Ardèvol; Omprakash Bande; Jerome Dabin; Zoran Dinev; Harry J Gilbert; Ting-Chou Hu; Javier Iglesias-Fernández; Carl Moreland; Carme Rovira; Aloysius Siriwardena; David K Smith; Gideon J Davies
The reaction coordinate of a bacterial GH47 α-mannosidase: a combined quantum mechanical and structural approach.
Angewandte Chemie (International ed. in English) 2012;51(44):10997-1001.
2012: Matthew S Macauley; Keith A Stubbs; Ajit Varki; Andrew J Bennet; Jefferson Chan; Gideon J Davies; Yuan He; Garrett E Whitworth; Scott A Yuzwa; Wesley F Zandberg; David J Vocadlo
Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of β-O-linked β-N-acetylglucosaminidase.
The Journal of biological chemistry 2012;287(34):28882-97.
2012: Andrew J Thompson; Keith S Wilson; Romil Benyamino; Esben P Friis; Tia Heu; Aubrey Jones; Tarana Shaghasi; Gideon J Davies
Structure of the catalytic core module of the Chaetomium thermophilum family GH6 cellobiohydrolase Cel6A.
Acta crystallographica. Section D, Biological crystallography 2012;68(Pt 8):875-82.
2012: Filip J Wyszynski; Tomoaki Yabe; Mervyn J Bibb; Gideon J Davies; Juan Pablo Gomez-Escribano; Soo Jae Lee; Seung Seo Lee; Hua Wang; Benjamin G Davis
Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates.
Nature chemistry 2012;4(7):539-46.
2012: Felix Mba Medie; Gideon J Davies; Michel Drancourt; Bernard Henrissat
Genome analyses highlight the different biological roles of cellulases.
Nature reviews. Microbiology 2012;10(3):227-34.
2012: Gideon J Davies; Antoni Planas; Carme Rovira
Conformational analyses of the reaction coordinate of glycosidases.
Accounts of chemical research 2012;45(2):308-16.
2012: Alicia Lammerts van Bueren; Esben P Friis; Suzie Otani; Keith S Wilson; Gideon J Davies
Three-dimensional structure of a thermophilic family GH11 xylanase from Thermobifida fusca.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 2):141-4.
2012: Andrew J Thompson; Tom Wennekes; Rohan J Williams; Spencer J Williams; Tanja M Wrodnigg; Tracey M Gloster; Zalihe Hakki; Kriangsak Songsrirote; Josef Spreitz; Arnold E Stütz; Jane E Thomas-Oates; Dominic S Alonzi; Terry D Butters; Gideon J Davies
Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(3):781-6.
2012: Shirley M Roberts; Gideon J Davies
The crystallization and structural analysis of cellulases (and other glycoside hydrolases): strategies and tactics.
Methods in enzymology 2012;510():141-68.
2011: R Jason Quinlan; Matt D Sweeney; Morten Tovborg; Theodora Tryfona; Clive P Walter; Feng Xu; Annika Anthonsen; Gideon J Davies; Paul Dupree; Katja Salomon Johansen; Christian Isak Jørgensen; Kristian B R M Krogh; Leila Lo Leggio; Harm Otten; Jens-Christian N Poulsen; Paul H Walton
Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(37):15079-84.
2011: Seung Seo Lee; Gideon J Davies; James Errey; Sung You Hong; Atsushi Izumi; Benjamin G Davis
Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase.
Nature chemical biology 2011;7(9):631-8.
2011: Oliver Spadiut; Gustav Sundqvist; Chunlin Xu; Gideon J Davies; Fredrika Gullfot; Farid M Ibatullin; Carlos Martinez-Fleites; Jonelle Peart; Marcus Ruda; Harry Brumer
Building custom polysaccharides in vitro with an efficient, broad-specificity xyloglucan glycosynthase and a fucosyltransferase.
Journal of the American Chemical Society 2011;133(28):10892-900.
2011: Johan Larsbrink; Atsushi Izumi; Farid M Ibatullin; Azadeh Nakhai; Harry J Gilbert; Gideon J Davies; Harry Brumer
Structural and enzymatic characterization of a glycoside hydrolase family 31 α-xylosidase from Cellvibrio japonicus involved in xyloglucan saccharification.
The Biochemical journal 2011;436(3):567-80.
2011: Morten M Nielsen; Michael D L Suits; Min Yang; Conor S Barry; Carlos Martinez-Fleites; Louise E Tailford; James E Flint; Claire Dumon; Benjamin G Davis; Harry J Gilbert; Gideon J Davies
Substrate and metal ion promiscuity in mannosylglycerate synthase.
The Journal of biological chemistry 2011;286(17):15155-64.
2011: Yuan He; Abigail K Bubb; Keith A Stubbs; Tracey M Gloster; Gideon J Davies
Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses.
Amino acids 2011;40(3):829-39.
2010: Cedric Montanier; James E Flint; David N Bolam; Hefang Xie; Ziyuan Liu; Artur Rogowski; David P Weiner; Supriya Ratnaparkhe; Didier Nurizzo; Shirley M Roberts; Johan P Turkenburg; Gideon J Davies; Harry J Gilbert
Circular permutation provides an evolutionary link between two families of calcium-dependent carbohydrate binding modules.
The Journal of biological chemistry 2010;285(41):31742-54.
2010: Gideon J Davies; Carlos Martinez-Fleites
GlaxoSmithKline Award Lecture. The O-GlcNAc modification: three-dimensional structure, enzymology and the development of selective inhibitors to probe disease.
Biochemical Society transactions 2010;38(5):1179-88.
2010: Matthew S Macauley; yuan he; Tracey M Gloster; Keith A Stubbs; Gideon J Davies; David J Vocadlo
Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes.
Chemistry & biology 2010;17(9):937-48.
2010: Alicia Lammerts van Bueren; Shinde D Popat; Chun-Hung Lin; Gideon J Davies
Structural and thermodynamic analyses of α-L-fucosidase inhibitors.
Chembiochem : a European journal of chemical biology 2010;11(14):1971-4.
2010: Justyna E Korczynska; Steffen Danielsen; Ulrika Schagerlöf; Johan P Turkenburg; Gideon J Davies; Keith S Wilson; Edward J Taylor
The structure of a family GH25 lysozyme from Aspergillus fumigatus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 9):973-7.
2010: Márcia A S Correia; D Wade Abbott; Tracey M Gloster; Vânia O Fernandes; José A M Prates; Cedric Montanier; Claire Dumon; Michael P Williamson; Richard B Tunnicliffe; Ziyuan Liu; James E Flint; Gideon J Davies; Bernard Henrissat; Pedro M Coutinho; Carlos M G A Fontes; Harry J Gilbert
Signature active site architectures illuminate the molecular basis for ligand specificity in family 35 carbohydrate binding module.
Biochemistry 2010;49(29):6193-205.
2010: Francesca Cardona; Andrea Goti; Camilla Parmeggiani; Paolo Parenti; Matilde Forcella; Paola Fusi; Laura Cipolla; Shirley M Roberts; Gideon J Davies; Tracey M Gloster
Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases.
Chemical communications (Cambridge, England) 2010;46(15):2629-31.
2010: James M Macdonald; Chris A Tarling; Edward J Taylor; Rebecca J Dennis; David S Myers; Spencer Knapp; Gideon J Davies; Stephen G Withers
Chitinase inhibition by chitobiose and chitotriose thiazolines.
Angewandte Chemie (International ed. in English) 2010;49(14):2599-602.
2010: Alicia Lammerts van Bueren; Albert Ardèvol; Jennifer Fayers-Kerr; Bo Luo; Yongmin Zhang; Matthieu Sollogoub; Yves Blériot; Carme Rovira; Gideon J Davies
Analysis of the reaction coordinate of alpha-L-fucosidases: a combined structural and quantum mechanical approach.
Journal of the American Chemical Society 2010;132(6):1804-6.
2010: yuan he; Matthew S Macauley; Keith A Stubbs; David J Vocadlo; Gideon J Davies
Visualizing the reaction coordinate of an O-GlcNAc hydrolase.
Journal of the American Chemical Society 2010;132(6):1807-9.
2010: James Errey; Seung Seo Lee; Robert P Gibson; Carlos Martinez-Fleites; Conor S Barry; Pierre M J Jung; Anthony C O'Sullivan; Benjamin G Davis; Gideon J Davies
Mechanistic insight into enzymatic glycosyl transfer with retention of configuration through analysis of glycomimetic inhibitors.
Angewandte Chemie (International ed. in English) 2010;49(7):1234-7.
2010: Yanping Zhu; Michael D L Suits; Andrew J Thompson; Sambhaji Chavan; Zoran Dinev; Claire Dumon; Nicola Smith; Kelley W Moremen; Yong Xiang; Aloysius Siriwardena; Spencer J Williams; Harry J Gilbert; Gideon J Davies
Mechanistic insights into a Ca2+-dependent family of alpha-mannosidases in a human gut symbiont.
Nature chemical biology 2010;6(2):125-32.
2010: Carlos Martinez-Fleites; yuan he; Gideon J Davies
Structural analyses of enzymes involved in the O-GlcNAc modification.
Biochimica et biophysica acta 2010;1800(2):122-33.
2010: Tracey M Gloster; Gideon J Davies
Glycosidase inhibition: assessing mimicry of the transition state.
Organic & biomolecular chemistry 2010;8(2):305-20.
2010: Michael D L Suits; Yanping Zhu; Edward J Taylor; Julia Walton; David L Zechel; Harry J Gilbert; Gideon J Davies
Structure and kinetic investigation of Streptococcus pyogenes family GH38 alpha-mannosidase.
PloS one 2010;5(2):e9006.
2009: Carlos Martinez-Fleites; Justyna E Korczynska; Gideon J Davies; Matthew J Cope; Johan P Turkenburg; Edward J Taylor
The crystal structure of a family GH25 lysozyme from Bacillus anthracis implies a neighboring-group catalytic mechanism with retention of anomeric configuration.
Carbohydrate research 2009;344(13):1753-7.
2009: Johan P Turkenburg; A Marek Brzozowski; Allan Svendsen; Torben V Borchert; Gideon J Davies; Keith S Wilson
Structure of a pullulanase from Bacillus acidopullulyticus.
Proteins 2009;76(2):516-9.
2009: Louise E Tailford; Valérie M-A Ducros; James E Flint; Shirley M Roberts; Carl Morland; David L Zechel; Nicola Smith; Mads E Bjørnvad; Torben V Borchert; Keith S Wilson; Gideon J Davies; Harry J Gilbert
Understanding how diverse beta-mannanases recognize heterogeneous substrates.
Biochemistry 2009;48(29):7009-18.
2009: Fredrika Gullfot; Farid M Ibatullin; Gustav Sundqvist; Gideon J Davies; Harry Brumer
Functional characterization of xyloglucan glycosynthases from GH7, GH12, and GH16 scaffolds.
Biomacromolecules 2009;10(7):1782-8.
2009: Matilde Aguilar-Moncayo; Tracey M Gloster; Johan P Turkenburg; M Isabel García-Moreno; Carmen Ortiz Mellet; Gideon J Davies; José M García Fernández
Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring.
Organic & biomolecular chemistry 2009;7(13):2738-47.
2009: Misty D Balcewich; Keith A Stubbs; yuan he; Terrence W James; Gideon J Davies; David J Vocadlo; Brian L Mark
Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ.
Protein science : a publication of the Protein Society 2009;18(7):1541-51.
2009: Zhenlian Ling; Michel D L Suits; Richard J Bingham; Neil C Bruce; Gideon J Davies; Antony J Fairbanks; James W B Moir; Edward J Taylor
The X-ray crystal structure of an Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase reveals a (beta/alpha)(8) catalytic domain, two ancillary domains and active site residues key for transglycosylation activity.
Journal of molecular biology 2009;389(1):1-9.
2009: Wendy A Offen; David L Zechel; Stephen G Withers; Harry J Gilbert; Gideon J Davies
Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis.
Chemical communications (Cambridge, England) 2009;(18):2484-6.
2009: Cedric Montanier; Victoria A Money; Virginia M R Pires; James E Flint; Benedita A Pinheiro; Arun Goyal; José A M Prates; Atsushi Izumi; Henrik Stålbrand; Carl Morland; Alan Cartmell; Katarina Kolenova; Evangelos Topakas; Eleanor J Dodson; David N Bolam; Gideon J Davies; Carlos M G A Fontes; Harry J Gilbert
The active site of a carbohydrate esterase displays divergent catalytic and noncatalytic binding functions.
PLoS biology 2009;7(3):e71.
2009: yuan he; Carlos Martinez-Fleites; Abigail Bubb; Tracey M Gloster; Gideon J Davies
Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase.
Carbohydrate research 2009;344(5):627-31.
2009: Cedric Montanier; Alicia Lammerts van Bueren; Claire Dumon; James E Flint; Marcia A Correia; Jose A Prates; Susan J Firbank; Richard J Lewis; Gilles G Grondin; Mariana G Ghinet; Tracey M Gloster; Cecile Herve; J Paul Knox; Brian G Talbot; Johan P Turkenburg; Janne Kerovuo; Ryszard Brzezinski; Carlos M G A Fontes; Gideon J Davies; Alisdair B Boraston; Harry J Gilbert
Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3065-70.
2009: Francesca Cardona; Camilla Parmeggiani; Enrico Faggi; Claudia Bonaccini; Paola Gratteri; Lyann Sim; Tracey M Gloster; Shirley Roberts; Gideon J Davies; David R Rose; Andrea Goti
Total syntheses of casuarine and its 6-O-alpha-glucoside: complementary inhibition towards glycoside hydrolases of the GH31 and GH37 families.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(7):1627-36.
2008: Matthew S Macauley; Abigail K Bubb; Carlos Martinez-Fleites; Gideon J Davies; David J Vocadlo
Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance.
The Journal of biological chemistry 2008;283(50):34687-95.
2008: Alan Cartmell; Evangelos Topakas; Valérie M-A Ducros; Michael D L Suits; Gideon J Davies; Harry J Gilbert
The Cellvibrio japonicus mannanase CjMan26C displays a unique exo-mode of action that is conferred by subtle changes to the distal region of the active site.
The Journal of biological chemistry 2008;283(49):34403-13.
2008: Karen M Ruane; Gideon J Davies; Carlos Martinez-Fleites
Crystal structure of a family GT4 glycosyltransferase from Bacillus anthracis ORF BA1558.
Proteins 2008;73(3):784-7.
2008: Matilde Aguilar; Tracey M Gloster; M Isabel García-Moreno; Carmen Ortiz Mellet; Gideon J Davies; Amadeu Llebaria; Josefina Casas; Meritxell Egido-Gabás; José M García Fernandez
Molecular basis for beta-glucosidase inhibition by ring-modified calystegine analogues.
Chembiochem : a European journal of chemical biology 2008;9(16):2612-8.
2008: Tracey M Gloster; Johan P Turkenburg; Jennifer R Potts; Bernard Henrissat; Gideon J Davies
Divergence of catalytic mechanism within a glycosidase family provides insight into evolution of carbohydrate metabolism by human gut flora.
Chemistry & biology 2008;15(10):1058-67.
2008: Gideon J Davies; James H Naismith
Chemistry's prodigal child: enzyme mechanism.
Current opinion in chemical biology 2008;12(5):529-31.
2008: David J Vocadlo; Gideon J Davies
Mechanistic insights into glycosidase chemistry.
Current opinion in chemical biology 2008;12(5):539-55.
2008: Scott A Yuzwa; Matthew S Macauley; Julia E Heinonen; Xiaoyang Shan; Rebecca J Dennis; yuan he; Garrett E Whitworth; Keith A Stubbs; Ernest J McEachern; Gideon J Davies; David J Vocadlo
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.
Nature chemical biology 2008;4(8):483-90.
2008: Carlos Martinez-Fleites; Matthew S Macauley; yuan he; David L Shen; David J Vocadlo; Gideon J Davies
Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation.
Nature structural & molecular biology 2008;15(7):764-5.
2008: Benedita A Pinheiro; Mark R Proctor; Carlos Martinez-Fleites; José A M Prates; Victoria A Money; Gideon J Davies; Edward A Bayer; Carlos M G A Fontesm; Henri Fierobe; Harry J Gilbert
The Clostridium cellulolyticum dockerin displays a dual binding mode for its cohesin partner.
The Journal of biological chemistry 2008;283(26):18422-30.
2008: Louise E Tailford; Wendy A Offen; Nicola L Smith; Claire Dumon; Carl Morland; Julie Gratien; Marie-Pierre Heck; Robert V Stick; Yves Blériot; Andrea Vasella; Harry J Gilbert; Gideon J Davies
Structural and biochemical evidence for a boat-like transition state in beta-mannosidases.
Nature chemical biology 2008;4(5):306-12.
2008: Victoria A Money; Alan Cartmell; Catarina I P D Guerreiro; Valerie M-A Ducros; Carlos M G A Fontes; Harry J Gilbert; Gideon J Davies
Probing the beta-1,3:1,4 glucanase, CtLic26A, with a thio-oligosaccharide and enzyme variants.
Organic & biomolecular chemistry 2008;6(5):851-3.
2008: Luke L Lairson; Bernard Henrissat; Gideon J Davies; Stephen G Withers
Glycosyltransferases: structures, functions, and mechanisms.
Annual review of biochemistry 2008;77():521-55.
2007: Melissa Brazier-Hicks; Wendy A Offen; Markus C Gershater; Timothy J Revett; Eng-Kiat Lim; Dianna J Bowles; Gideon J Davies; Robert Edwards
Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(51):20238-43.
2007: Adrian Scaffidi; Keith A Stubbs; Rebecca J Dennis; Edward J Taylor; Gideon J Davies; David J Vocadlo; Robert V Stick
A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of beta-N-acetylglucosaminidases.
Organic & biomolecular chemistry 2007;5(18):3013-9.
2007: Tracey M Gloster; Farid M Ibatullin; Katherine McAuley; Jens M Eklöf; Shirley Roberts; Johan P Turkenburg; Mads Eskelund Bjørnvad; Per Linå Jørgensen; Steffen Danielsen; Katja S Johansen; Torben V Borchert; Keith S Wilson; Harry Brumer; Gideon J Davies
Characterization and three-dimensional structures of two distinct bacterial xyloglucanases from families GH5 and GH12.
The Journal of biological chemistry 2007;282(26):19177-89.
2007: Louise E Tailford; Victoria A Money; Nicola L Smith; Claire Dumon; Gideon J Davies; Harry J Gilbert
Mannose foraging by Bacteroides thetaiotaomicron: structure and specificity of the beta-mannosidase, BtMan2A.
The Journal of biological chemistry 2007;282(15):11291-9.
2007: David N Bolam; Shirley Roberts; Mark R Proctor; Johan P Turkenburg; Eleanor J Dodson; Carlos Martinez-Fleites; Min Yang; Benjamin G Davis; Gideon J Davies; Harry J Gilbert
The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5336-41.
2007: Tracey M Gloster; Peter Meloncelli; Robert V Stick; David L Zechel; Andrea Vasella; Gideon J Davies
Glycosidase inhibition: an assessment of the binding of 18 putative transition-state mimics.
Journal of the American Chemical Society 2007;129(8):2345-54.
2007: Ana L Carvalho; Fernando M V Dias; Tibor Nagy; José A M Prates; Mark R Proctor; Nicola Smith; Edward A Bayer; Gideon J Davies; Luís M A Ferreira; Maria João Romão; Carlos M G A Fontes; Harry J Gilbert
Evidence for a dual binding mode of dockerin modules to cohesins.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3089-94.
2007: Tracey M Gloster; Robert Madsen; Gideon J Davies
Structural basis for cyclophellitol inhibition of a beta-glucosidase.
Organic & biomolecular chemistry 2007;5(3):444-6.
2007: Garrett E Whitworth; Matthew S Macauley; Keith A Stubbs; Rebecca J Dennis; Edward J Taylor; Gideon J Davies; Ian R Greig; David J Vocadlo
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise.
Journal of the American Chemical Society 2007;129(3):635-44.
2007: Robert Gibson; Tracey M Gloster; Shirley Roberts; R Antony J Warren; Isabel Storch de Gracia; Angela García; Jose Luis Chiara; Gideon J Davies
Molecular basis for trehalase inhibition revealed by the structure of trehalase in complex with potent inhibitors.
Angewandte Chemie (International ed. in English) 2007;46(22):4115-9.
2007: Min Yang; Gideon J Davies; Benjamin G Davis
A glycosynthase catalyst for the synthesis of flavonoid glycosides.
Angewandte Chemie (International ed. in English) 2007;46(21):3885-8.
2007: Leoni Oberbarnscheidt; Edward J Taylor; Gideon J Davies; Tracey M Gloster
Structure of a carbohydrate esterase from Bacillus anthracis.
Proteins 2007;66(1):250-2.
2006: Bhagavathy Shanmugasundaram; Aleksandra W Debowski; Rebecca J Dennis; Gideon J Davies; David J Vocadlo; Andrea Vasella
Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor.
Chemical communications (Cambridge, England) 2006;(42):4372-4.
2006: Carlos Martinez-Fleites; Mark Proctor; Shirley Roberts; David N Bolam; Harry J Gilbert; Gideon J Davies
Insights into the synthesis of lipopolysaccharide and antibiotics through the structures of two retaining glycosyltransferases from family GT4.
Chemistry & biology 2006;13(11):1143-52.
2006: William L Sheldon; Matthew S Macauley; Edward J Taylor; Charlotte E Robinson; Simon Charnock; Gideon J Davies; David J Vocadlo; Gary W Black
Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase.
The Biochemical journal 2006;399(2):241-7.
2006: Tracey M Gloster; Shirley Roberts; Giuseppe Perugino; Mosè Rossi; Marco Moracci; Narendra Panday; Miroslav Terinek; Andrea Vasella; Gideon J Davies
Structural, kinetic, and thermodynamic analysis of glucoimidazole-derived glycosidase inhibitors.
Biochemistry 2006;45(39):11879-84.
2006: Carlos Martinez-Fleites; Catarina I P D Guerreiro; Martin J Baumann; Edward J Taylor; José A M Prates; Luís M A Ferreira; Carlos M G A Fontes; Harry Brumer; Gideon J Davies
Crystal structures of Clostridium thermocellum xyloglucanase, XGH74A, reveal the structural basis for xyloglucan recognition and degradation.
The Journal of biological chemistry 2006;281(34):24922-33.
2006: Victoria A Money; Nicola L Smith; Adrian Scaffidi; Robert V Stick; Harry J Gilbert; Gideon J Davies
Substrate distortion by a lichenase highlights the different conformational itineraries harnessed by related glycoside hydrolases.
Angewandte Chemie (International ed. in English) 2006;45(31):5136-40.
2006: Joanna L Henshaw; Ami Horne-Bitschy; Alicia Lammerts van Bueren; Victoria A Money; David N Bolam; Mirjam Czjzek; Nathan A Ekborg; Ronald M Weiner; Steven W Hutcheson; Gideon J Davies; Alisdair B Boraston; Harry J Gilbert
Family 6 carbohydrate binding modules in beta-agarases display exquisite selectivity for the non-reducing termini of agarose chains.
The Journal of biological chemistry 2006;281(25):17099-107.
2006: Tracey M Gloster; Robert Madsen; Gideon J Davies
Dissection of conformationally restricted inhibitors binding to a beta-glucosidase.
Chembiochem : a European journal of chemical biology 2006;7(5):738-42.
2006: Edward J Taylor; Tracey M Gloster; Johan P Turkenburg; Florence Vincent; Andrzej M Brzozowski; Claude Dupont; François Shareck; Maria S J Centeno; José A M Prates; Vladimír Puchart; Luís M A Ferreira; Carlos M G A Fontes; Peter Biely; Gideon J Davies
Structure and activity of two metal ion-dependent acetylxylan esterases involved in plant cell wall degradation reveals a close similarity to peptidoglycan deacetylases.
The Journal of biological chemistry 2006;281(16):10968-75.
2006: Rebecca J Dennis; Edward J Taylor; Matthew S Macauley; Keith A Stubbs; Johan P Turkenburg; Samuel J Hart; Gary N Black; David J Vocadlo; Gideon J Davies
Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity.
Nature structural & molecular biology 2006;13(4):365-71.
2006: Edward J Taylor; Nicola L Smith; Johan P Turkenburg; Simone D'Souza; Harry J Gilbert; Gideon J Davies
Structural insight into the ligand specificity of a thermostable family 51 arabinofuranosidase, Araf51, from Clostridium thermocellum.
The Biochemical journal 2006;395(1):31-7.
2006: Wendy Offen; Carlos Martinez-Fleites; Min Yang; Eng Kiat-Lim; Benjamin G Davis; Chris A Tarling; Christopher M Ford; Dianna J Bowles; Gideon J Davies
Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification.
The EMBO journal 2006;25(6):1396-405.
2005: Nicola L Smith; Edward J Taylor; Anna-Marie Lindsay; Simon Charnock; Johan P Turkenburg; Eleanor J Dodson; Gideon J Davies; Gary W Black
Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded beta-helix.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(49):17652-7.
2005: Gideon J Davies; Tracey M Gloster; Bernard Henrissat
Recent structural insights into the expanding world of carbohydrate-active enzymes.
Current opinion in structural biology 2005;15(6):637-45.
2005: Edward J Taylor; Arun Goyal; Catarina I P D Guerreiro; José A M Prates; Victoria A Money; Natalie Ferry; Carl Morland; Antoni Planas; James A Macdonald; Robert V Stick; Harry J Gilbert; Carlos M G A Fontes; Gideon J Davies
How family 26 glycoside hydrolases orchestrate catalysis on different polysaccharides: structure and activity of a Clostridium thermocellum lichenase, CtLic26A.
The Journal of biological chemistry 2005;280(38):32761-7.
2005: Carlos Martínez-Fleites; Miguel Ortíz-Lombardía; Tirso Pons; Nicolas Tarbouriech; Edward J Taylor; Juan G Arrieta; Lázaro Hernández; Gideon J Davies
Crystal structure of levansucrase from the Gram-negative bacterium Gluconacetobacter diazotrophicus.
The Biochemical journal 2005;390(Pt 1):19-27.
2005: James Flint; Edward Taylor; Min Yang; David N Bolam; Louise E Tailford; Carlos Martinez-Fleites; Eleanor J Dodson; Benjamin G Davis; Harry J Gilbert; Gideon J Davies
Structural dissection and high-throughput screening of mannosylglycerate synthase.
Nature structural & molecular biology 2005;12(7):608-14.
2005: Ana L Carvalho; Virginia M R Pires; Tracey M Gloster; Johan P Turkenburg; José A M Prates; Luís M A Ferreira; Maria João Romão; Gideon J Davies; Carlos M G A Fontes; Harry J Gilbert
Insights into the structural determinants of cohesin-dockerin specificity revealed by the crystal structure of the type II cohesin from Clostridium thermocellum SdbA.
Journal of molecular biology 2005;349(5):909-15.
2005: James Flint; David N Bolam; Didier Nurizzo; Edward J Taylor; Michael P Williamson; Christopher Walters; Gideon J Davies; Harry J Gilbert
Probing the mechanism of ligand recognition in family 29 carbohydrate-binding modules.
The Journal of biological chemistry 2005;280(25):23718-26.
2005: Annabelle Varrot; Sabine Leydier; Gavin Pell; James M Macdonald; Robert V Stick; Bernard Henrissat; Harry J Gilbert; Gideon J Davies
Mycobacterium tuberculosis strains possess functional cellulases.
The Journal of biological chemistry 2005;280(21):20181-4.
2005: Florence Vincent; Gideon J Davies; James A Brannigan
Structure and kinetics of a monomeric glucosamine 6-phosphate deaminase: missing link of the NagB superfamily?
The Journal of biological chemistry 2005;280(20):19649-55.
2005: Mark R Proctor; Edward J Taylor; Didier Nurizzo; Johan P Turkenburg; Ruth M Lloyd; Maria Vardakou; Gideon J Davies; Harry J Gilbert
Tailored catalysts for plant cell-wall degradation: redesigning the exo/endo preference of Cellvibrio japonicus arabinanase 43A.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2697-702.
2005: Annabelle Varrot; vivian yip; Yunsong Li; Shyamala S Rajan; Xiaojing Yang; Wayne F Anderson; John Thompson; Stephen G Withers; Gideon J Davies
NAD+ and metal-ion dependent hydrolysis by family 4 glycosidases: structural insight into specificity for phospho-beta-D-glucosides.
Journal of molecular biology 2005;346(2):423-35.
2005: Nicolas Tarbouriech; José A M Prates; Carlos M G A Fontes; Gideon J Davies
Molecular determinants of substrate specificity in the feruloyl esterase module of xylanase 10B from Clostridium thermocellum.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 2):194-7.
2005: Gideon J Davies; Andrzej M Brzozowski; Zbigniew Dauter; Michael D Rasmussen; Torben V Borchert; Keith S Wilson
Structure of a Bacillus halmapalus family 13 alpha-amylase, BHA, in complex with an acarbose-derived nonasaccharide at 2.1 A resolution.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 2):190-3.
2004: Simon R Andrews; Edward J Taylor; Gavin Pell; Florence Vincent; Valérie M-A Ducros; Gideon J Davies; Jeremy H Lakey; Harry J Gilbert
The use of forced protein evolution to investigate and improve stability of family 10 xylanases. The production of Ca2+-independent stable xylanases.
The Journal of biological chemistry 2004;279(52):54369-79.
2004: Tracey M Gloster; James M Macdonald; Chris A Tarling; Robert V Stick; Stephen G Withers; Gideon J Davies
Structural, thermodynamic, and kinetic analyses of tetrahydrooxazine-derived inhibitors bound to beta-glucosidases.
The Journal of biological chemistry 2004;279(47):49236-42.
2004: Florence Vincent; Tracey M Gloster; James Macdonald; Carl Morland; Robert V Stick; Fernando M V Dias; José A M Prates; Carlos M G A Fontes; Harry J Gilbert; Gideon J Davies
Common inhibition of both beta-glucosidases and beta-mannosidases by isofagomine lactam reflects different conformational itineraries for pyranoside hydrolysis.
Chembiochem : a European journal of chemical biology 2004;5(11):1596-9.
2004: Alisdair B Boraston; David N Bolam; Harry J Gilbert; Gideon J Davies
Carbohydrate-binding modules: fine-tuning polysaccharide recognition.
The Biochemical journal 2004;382(Pt 3):769-81.
2004: Shyamala S Rajan; Xiaojing Yang; Frank Collart; vivian yip; Stephen G Withers; Annabelle Varrot; John Thompson; Gideon J Davies; Wayne F Anderson
Novel catalytic mechanism of glycoside hydrolysis based on the structure of an NAD+/Mn2+ -dependent phospho-alpha-glucosidase from Bacillus subtilis.
Structure (London, England : 1993) 2004;12(9):1619-29.
2004: Tracey M Gloster; Spencer J Williams; Shirley Roberts; Chris A Tarling; Jacqueline Wicki; Stephen G Withers; Gideon J Davies
Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A.
Chemical communications (Cambridge, England) 2004;(16):1794-5.
2004: Spencer J Williams; Gideon J Davies
A master of its sulfate.
Nature structural & molecular biology 2004;11(8):686-7.
2004: vivian yip; Annabelle Varrot; Gideon J Davies; Shyamala S Rajan; Xiaojing Yang; John Thompson; Wayne F Anderson; Stephen G Withers
An unusual mechanism of glycoside hydrolysis involving redox and elimination steps by a family 4 beta-glycosidase from Thermotoga maritima.
Journal of the American Chemical Society 2004;126(27):8354-5.
2004: Sheelan Jamal-Talabani; Alisdair B Boraston; Johan P Turkenburg; Nicolas Tarbouriech; Valérie M-A Ducros; Gideon J Davies
Ab initio structure determination and functional characterization of CBM36; a new family of calcium-dependent carbohydrate binding modules.
Structure (London, England : 1993) 2004;12(7):1177-87.
2004: Fernando M V Dias; Florence Vincent; Gavin Pell; José A M Prates; Maria S J Centeno; Louise E Tailford; Luís M A Ferreira; Carlos M G A Fontes; Gideon J Davies; Harry J Gilbert
Insights into the molecular determinants of substrate specificity in glycoside hydrolase family 5 revealed by the crystal structure and kinetics of Cellvibrio mixtus mannosidase 5A.
The Journal of biological chemistry 2004;279(24):25517-26.
2004: Sheelan Jamal; Didier Nurizzo; Alisdair B Boraston; Gideon J Davies
X-ray crystal structure of a non-crystalline cellulose-specific carbohydrate-binding module: CBM28.
Journal of molecular biology 2004;339(2):253-8.
2004: Tracey M Gloster; Shirley Roberts; Valérie M-A Ducros; Giuseppe Perugino; Mosè Rossi; Roland Hoos; Marco Moracci; Andrea Vasella; Gideon J Davies
Structural studies of the beta-glycosidase from Sulfolobus solfataricus in complex with covalently and noncovalently bound inhibitors.
Biochemistry 2004;43(20):6101-9.
2004: James Flint; Didier Nurizzo; Stephen E Harding; Emma Longman; Gideon J Davies; Harry J Gilbert; David N Bolam
Ligand-mediated dimerization of a carbohydrate-binding molecule reveals a novel mechanism for protein-carbohydrate recognition.
Journal of molecular biology 2004;337(2):417-26.
2004: Gavin Pell; Lóránd Szabo; Simon Charnock; Hefang Xie; Tracey M Gloster; Gideon J Davies; Harry J Gilbert
Structural and biochemical analysis of Cellvibrio japonicus xylanase 10C: how variation in substrate-binding cleft influences the catalytic profile of family GH-10 xylanases.
The Journal of biological chemistry 2004;279(12):11777-88.
2004: Gavin Pell; Edward J Taylor; Tracey M Gloster; Johan P Turkenburg; Carlos M G A Fontes; Luís M A Ferreira; Tibor Nagy; Samantha J Clark; Gideon J Davies; Harry J Gilbert
The mechanisms by which family 10 glycoside hydrolases bind decorated substrates.
The Journal of biological chemistry 2004;279(10):9597-605.
2004: Florence Vincent; David Yates; Elspeth Garman; Gideon J Davies; James A Brannigan
The three-dimensional structure of the N-acetylglucosamine-6-phosphate deacetylase, NagA, from Bacillus subtilis: a member of the urease superfamily.
The Journal of biological chemistry 2004;279(4):2809-16.
2004: Robert Gibson; Chris A Tarling; Shirley Roberts; Stephen G Withers; Gideon J Davies
The donor subsite of trehalose-6-phosphate synthase: binary complexes with UDP-glucose and UDP-2-deoxy-2-fluoro-glucose at 2 A resolution.
The Journal of biological chemistry 2004;279(3):1950-5.
2004: Carlos Martínez-Fleites; Nicolas Tarbouriech; Miguel Ortiz-Lombardia; Edward Taylor; Armando Rodríguez; Ricardo Ramírez; Lázaro Hernández; Gideon J Davies
Crystallization and preliminary X-ray diffraction analysis of levansucrase (LsdA) from Gluconacetobacter diazotrophicus SRT4.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 1):181-3.
2003: David L Zechel; Alisdair B Boraston; Tracey M Gloster; Catherine M Boraston; James M Macdonald; D Matthew G Tilbrook; Robert V Stick; Gideon J Davies
Iminosugar glycosidase inhibitors: structural and thermodynamic dissection of the binding of isofagomine and 1-deoxynojirimycin to beta-glucosidases.
Journal of the American Chemical Society 2003;125(47):14313-23.
2003: Ana L Carvalho; Fernando M V Dias; José A M Prates; Tibor Nagy; Harry J Gilbert; Gideon J Davies; Luís M A Ferreira; Maria João Romão; Carlos M G A Fontes
Cellulosome assembly revealed by the crystal structure of the cohesin-dockerin complex.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):13809-14.
2003: Florence Vincent; Simon Charnock; Koen H G Verschueren; Johan P Turkenburg; David Scott; Wendy A Offen; Shirley Roberts; Gavin Pell; Harry J Gilbert; Gideon J Davies; James A Brannigan
Multifunctional xylooligosaccharide/cephalosporin C deacetylase revealed by the hexameric structure of the Bacillus subtilis enzyme at 1.9A resolution.
Journal of molecular biology 2003;330(3):593-606.
2003: Valérie M-A Ducros; Chris A Tarling; David L Zechel; Andrzej M Brzozowski; Torben P Frandsen; Ingemar von Ossowski; Martin Schülein; Stephen G Withers; Gideon J Davies
Anatomy of glycosynthesis: structure and kinetics of the Humicola insolens Cel7B E197A and E197S glycosynthase mutants.
Chemistry & biology 2003;10(7):619-28.
2003: Annabelle Varrot; Torben P Frandsen; Ingemar von Ossowski; Véronique Boyer; Sylvain Cottaz; Hugues Driguez; Martin Schülein; Gideon J Davies
Structural basis for ligand binding and processivity in cellobiohydrolase Cel6A from Humicola insolens.
Structure (London, England : 1993) 2003;11(7):855-64.
2003: Annabelle Varrot; Chris A Tarling; James M Macdonald; Robert V Stick; David L Zechel; Stephen G Withers; Gideon J Davies
Direct observation of the protonation state of an imino sugar glycosidase inhibitor upon binding.
Journal of the American Chemical Society 2003;125(25):7496-7.
2003: Michael Jahn; Dominik Stoll; R Antony J Warren; Lóránd Szabó; Pritpal Singh; Harry J Gilbert; Valérie M-A Ducros; Gideon J Davies; Stephen G Withers
Expansion of the glycosynthase repertoire to produce defined manno-oligosaccharides.
Chemical communications (Cambridge, England) 2003;(12):1327-9.
2003: Alisdair B Boraston; Timothy J Revett; Catherine M Boraston; Didier Nurizzo; Gideon J Davies
Structural and thermodynamic dissection of specific mannan recognition by a carbohydrate binding module, TmCBM27.
Structure (London, England : 1993) 2003;11(6):665-75.
2003: Gideon J Davies; Valérie M-A Ducros; Annabelle Varrot; David L Zechel
Mapping the conformational itinerary of beta-glycosidases by X-ray crystallography.
Biochemical Society transactions 2003;31(Pt 3):523-7.
2003: Tibor Nagy; Didier Nurizzo; Gideon J Davies; Peter Biely; Jeremy H Lakey; David N Bolam; Harry J Gilbert
The alpha-glucuronidase, GlcA67A, of Cellvibrio japonicus utilizes the carboxylate and methyl groups of aldobiouronic acid as important substrate recognition determinants.
The Journal of biological chemistry 2003;278(22):20286-92.
2003: Pedro M Coutinho; Emeline Deleury; Gideon J Davies; Bernard Henrissat
An evolving hierarchical family classification for glycosyltransferases.
Journal of molecular biology 2003;328(2):307-17.
2003: Annabelle Varrot; James Macdonald; Robert V Stick; Gavin Pell; Harry J Gilbert; Gideon J Davies
Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting beta-glucosidases.
Chemical communications (Cambridge, England) 2003;(8):946-7.
2003: Tracey M Gloster; Spencer J Williams; Chris A Tarling; Shirley Roberts; Claude Dupont; Pascalé Jodoin; François Shareck; Stephen G Withers; Gideon J Davies
A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer.
Chemical communications (Cambridge, England) 2003;(8):944-5.
2003: Annabelle Varrot; Gideon J Davies
Direct experimental observation of the hydrogen-bonding network of a glycosidase along its reaction coordinate revealed by atomic resolution analyses of endoglucanase Cel5A.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 3):447-52.
2002: Robert Gibson; Johan P Turkenburg; Simon Charnock; Ruth Lloyd; Gideon J Davies
Insights into trehalose synthesis provided by the structure of the retaining glucosyltransferase OtsA.
Chemistry & biology 2002;9(12):1337-46.
2002: Annabelle Varrot; Torben P Frandsen; Hugues Driguez; Gideon J Davies
Structure of the Humicola insolens cellobiohydrolase Cel6A D416A mutant in complex with a non-hydrolysable substrate analogue, methyl cellobiosyl-4-thio-beta-cellobioside, at 1.9 A.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 12):2201-4.
2002: Simon Charnock; David N Bolam; Didier Nurizzo; Lóránd Szabó; Vincent A McKie; Harry J Gilbert; Gideon J Davies
Promiscuity in ligand-binding: The three-dimensional structure of a Piromyces carbohydrate-binding module, CBM29-2, in complex with cello- and mannohexaose.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14077-82.
2002: Andrea Vasella; Gideon J Davies; Matthias Böhm
Glycosidase mechanisms.
Current opinion in chemical biology 2002;6(5):619-29.
2002: Simon Charnock; Ian E Brown; Johan P Turkenburg; Gary W Black; Gideon J Davies
Convergent evolution sheds light on the anti-beta -elimination mechanism common to family 1 and 10 polysaccharide lyases.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12067-72.
2002: Didier Nurizzo; Johan P Turkenburg; Simon Charnock; Shirley M Roberts; Eleanor J Dodson; Vincent A McKie; Edward J Taylor; Harry J Gilbert; Gideon J Davies
Cellvibrio japonicus alpha-L-arabinanase 43A has a novel five-blade beta-propeller fold.
Nature structural biology 2002;9(9):665-8.
2002: Valérie M-A Ducros; David L Zechel; Garib N Murshudov; Harry J Gilbert; Lóránd Szabó; Dominik Stoll; Stephen G Withers; Gideon J Davies
Substrate distortion by a beta-mannanase: snapshots of the Michaelis and covalent-intermediate complexes suggest a B(2,5) conformation for the transition state.
Angewandte Chemie (International ed. in English) 2002;41(15):2824-7.
2002: Alisdair B Boraston; Didier Nurizzo; Valerie Notenboom; Valérie M-A Ducros; David R Rose; Douglas G Kilburn; Gideon J Davies
Differential oligosaccharide recognition by evolutionarily-related beta-1,4 and beta-1,3 glucan-binding modules.
Journal of molecular biology 2002;319(5):1143-56.
2002: Gideon J Davies; Bernard Henrissat
Structural enzymology of carbohydrate-active enzymes: implications for the post-genomic era.
Biochemical Society transactions 2002;30(2):291-7.
2002: Didier Nurizzo; Tibor Nagy; Harry J Gilbert; Gideon J Davies
The structural basis for catalysis and specificity of the Pseudomonas cellulosa alpha-glucuronidase, GlcA67A.
Structure (London, England : 1993) 2002;10(4):547-56.
2002: Robert Gibson; Ruth M Lloyd; Simon Charnock; Gideon J Davies
Characterization of Escherichia coli OtsA, a trehalose-6-phosphate synthase from glycosyltransferase family 20.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 2):349-51.
2001: L Szabo; S Jamal; Hefang Xie; Simon Charnock; David N Bolam; Harry J Gilbert; Gideon J Davies
Structure of a family 15 carbohydrate-binding module in complex with xylopentaose. Evidence that xylan binds in an approximate 3-fold helical conformation.
The Journal of biological chemistry 2001;276(52):49061-5.
2001: Nicolas Tarbouriech; Simon Charnock; Gideon J Davies
Three-dimensional structures of the Mn and Mg dTDP complexes of the family GT-2 glycosyltransferase SpsA: a comparison with related NDP-sugar glycosyltransferases.
Journal of molecular biology 2001;314(4):655-61.
2001: José A M Prates; Nicolas Tarbouriech; Simon Charnock; Carlos M G A Fontes; Luís M A Ferreira; Gideon J Davies
The structure of the feruloyl esterase module of xylanase 10B from Clostridium thermocellum provides insights into substrate recognition.
Structure (London, England : 1993) 2001;9(12):1183-90.
2001: Annabelle Varrot; Martin Schülein; S Fruchard; Hugues Driguez; Gideon J Davies
Atomic resolution structure of endoglucanase Cel5A in complex with methyl 4,4II,4III,4IV-tetrathio-alpha-cellopentoside highlights the alternative binding modes targeted by substrate mimics.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 11):1739-42.
2001: Bernard Henrissat; Pedro M Coutinho; Gideon J Davies
A census of carbohydrate-active enzymes in the genome of Arabidopsis thaliana.
Plant molecular biology 2001;47(1-2):55-72.
2001: E Sabini; Keith S Wilson; Steffen Danielsen; Martin Schülein; Gideon J Davies
Oligosaccharide binding to family 11 xylanases: both covalent intermediate and mutant product complexes display (2,5)B conformations at the active centre.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 9):1344-7.
2001: Hefang Xie; Harry J Gilbert; Simon Charnock; Gideon J Davies; Michael P Williamson; Pete Simpson; Srinivasarao Raghothama; Carlos M G A Fontes; Fernando M V Dias; Luís M A Ferreira; David N Bolam
Clostridium thermocellum Xyn10B carbohydrate-binding module 22-2: the role of conserved amino acids in ligand binding.
Biochemistry 2001;40(31):9167-76.
2001: Simon Charnock; Ian E Brown; Johan P Turkenburg; Gary W Black; Gideon J Davies
Characterization of a novel pectate lyase, Pel10A, from Pseudomonas cellulosa.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 8):1141-3.
2001: Edward J Taylor; Simon Charnock; J Colby; Gideon J Davies; Gary W Black
Cloning, purification and characterization of the 6-phospho-3-hexulose isomerase YckF from Bacillus subtilis.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 8):1138-40.
2001: Sébastien Fort; Annabelle Varrot; Martin Schülein; Sylvain Cottaz; Hugues Driguez; Gideon J Davies
Mixed-linkage cellooligosaccharides: a new class of glycoside hydrolase inhibitors.
Chembiochem : a European journal of chemical biology 2001;2(5):319-25.
2001: Ian E Brown; M H Mallen; Simon Charnock; Gideon J Davies; Gary W Black
Pectate lyase 10A from Pseudomonas cellulosa is a modular enzyme containing a family 2a carbohydrate-binding module.
The Biochemical journal 2001;355(Pt 1):155-65.
2001: Valérie M-A Ducros; Andrzej M Brzozowski; Keith S Wilson; P Ostergaard ; P Schneider; A Svendson ; Gideon J Davies
Structure of the laccase from Coprinus cinereus at 1.68 A resolution: evidence for different 'type 2 Cu-depleted' isoforms.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 2):333-6.
2001: Simon Charnock; Bernard Henrissat; Gideon J Davies
Three-dimensional structures of UDP-sugar glycosyltransferases illuminate the biosynthesis of plant polysaccharides.
Plant physiology 2001;125(2):527-31.
2000: Bernard Henrissat; Gideon J Davies
Glycoside hydrolases and glycosyltransferases. Families, modules, and implications for genomics.
Plant physiology 2000;124(4):1515-9.
2000: Andrzej M Brzozowski; DM Lawson; Johan P Turkenburg; H Bisgaard-Frantzen; Allan Svendsen; Torben V Borchert; Zbigniew Dauter; Keith S Wilson; Gideon J Davies
Structural analysis of a chimeric bacterial alpha-amylase. High-resolution analysis of native and ligand complexes.
Biochemistry 2000;39(31):9099-107.
2000: Valérie M-A Ducros; Simon Charnock; Urszula Derewenda; Zygmunt S Derewenda; Zbigniew Dauter; Claude Dupont; François Shareck; Rolf Morosoli; Dieter Kluepfel; Gideon J Davies
Substrate specificity in glycoside hydrolase family 10. Structural and kinetic analysis of the Streptomyces lividans xylanase 10A.
The Journal of biological chemistry 2000;275(30):23020-6.
2000: Simon R Andrews; Simon Charnock; Jeremy H Lakey; Gideon J Davies; Marc Claeyssens; Wim Nerinckx; M Underwood; Michael L Sinnott; R A Warren; Harry J Gilbert
Substrate specificity in glycoside hydrolase family 10. Tyrosine 87 and leucine 314 play a pivotal role in discriminating between glucose and xylose binding in the proximal active site of Pseudomonas cellulosa xylanase 10A.
The Journal of biological chemistry 2000;275(30):23027-33.
2000: Gideon J Davies; Andrzej M Brzozowski; M Dauter; Annabelle Varrot; Martin Schülein
Structure and function of Humicola insolens family 6 cellulases: structure of the endoglucanase, Cel6B, at 1.6 A resolution.
The Biochemical journal 2000;348 Pt 1():201-7.
2000: Simon Charnock; David N Bolam; Johan P Turkenburg; Harry J Gilbert; Luís M A Ferreira; Gideon J Davies; Carlos M G A Fontes
The X6 "thermostabilizing" domains of xylanases are carbohydrate-binding modules: structure and biochemistry of the Clostridium thermocellum X6b domain.
Biochemistry 2000;39(17):5013-21.
2000: Annabelle Varrot; Martin Schülein; Gideon J Davies
Insights into ligand-induced conformational change in Cel5A from Bacillus agaradhaerens revealed by a catalytically active crystal form.
Journal of molecular biology 2000;297(3):819-28.
1999: Annabelle Varrot; Martin Schülein; Gideon J Davies
Structural changes of the active site tunnel of Humicola insolens cellobiohydrolase, Cel6A, upon oligosaccharide binding.
Biochemistry 1999;38(28):8884-91.
1999: E Sabini; Gerlind Sulzenbacher; M Dauter; Zbigniew Dauter; Per Linå Jørgensen; Martin Schülein; Claude Dupont; Gideon J Davies; Keith S Wilson
Catalysis and specificity in enzymatic glycoside hydrolysis: a 2,5B conformation for the glycosyl-enzyme intermediate revealed by the structure of the Bacillus agaradhaerens family 11 xylanase.
Chemistry & biology 1999;6(7):483-92.
1999: Zbigniew Dauter; M Dauter; Andrzej M Brzozowski; S Christensen; Torben V Borchert; L Beier; Keith S Wilson; Gideon J Davies
X-ray structure of Novamyl, the five-domain "maltogenic" alpha-amylase from Bacillus stearothermophilus: maltose and acarbose complexes at 1.7A resolution.
Biochemistry 1999;38(26):8385-92.
1999: Annabelle Varrot; H Yamamoto; J Sekiguchi; John Thompson; Gideon J Davies
Crystallization and preliminary X-ray analysis of the 6-phospho-alpha-glucosidase from Bacillus subtilis.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 6):1212-4.
1999: Simon Charnock; Gideon J Davies
Structure of the nucleotide-diphospho-sugar transferase, SpsA from Bacillus subtilis, in native and nucleotide-complexed forms.
Biochemistry 1999;38(20):6380-5.
1999: E Sabini; Andrzej M Brzozowski; M Dauter; Gideon J Davies; Keith S Wilson; Marja Paloheimo; Pirkko Suominen; M Siika-Aho; Merja Penttilä
Crystallization and preliminary X-ray crystallographic analysis of a Trichoderma reesei beta-mannanase from glycoside hydrolase family 5.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 5):1058-60.
1999: Gerlind Sulzenbacher; LF Mackenzie; Keith S Wilson; Stephen G Withers; Claude Dupont; Gideon J Davies
The crystal structure of a 2-fluorocellotriosyl complex of the Streptomyces lividans endoglucanase CelB2 at 1.2 A resolution.
Biochemistry 1999;38(15):4826-33.
1999: Simon Charnock; Gideon J Davies
Cloning, crystallization and preliminary X-ray analysis of a nucleotide-diphospho-sugar transferase spsA from Bacillus subtilis.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 3):677-8.
1999: Annabelle Varrot; S Hastrup; Martin Schülein; Gideon J Davies
Crystal structure of the catalytic core domain of the family 6 cellobiohydrolase II, Cel6A, from Humicola insolens, at 1.92 A resolution.
The Biochemical journal 1999;337 ( Pt 2)():297-304.
1998: LF Mackenzie; Gerlind Sulzenbacher; C Divne; T A Jones; H F Wöldike; Martin Schülein; Stephen G Withers; Gideon J Davies
Crystal structure of the family 7 endoglucanase I (Cel7B) from Humicola insolens at 2.2 A resolution and identification of the catalytic nucleophile by trapping of the covalent glycosyl-enzyme intermediate.
The Biochemical journal 1998;335 ( Pt 2)():409-16.
1998: Gideon J Davies; LF Mackenzie; Annabelle Varrot; M Dauter; Andrzej M Brzozowski; Martin Schülein; Stephen G Withers
Snapshots along an enzymatic reaction coordinate: analysis of a retaining beta-glycoside hydrolase.
Biochemistry 1998;37(34):11707-13.
1998: Eleanor J Dodson; Gideon J Davies; Victor S Lamzin; Garib N Murshudov; Keith S Wilson
Validation tools: can they indicate the information content of macromolecular crystal structures?
Structure (London, England : 1993) 1998;6(6):685-90.
1998: Gideon J Davies
Structural studies on cellulases.
Biochemical Society transactions 1998;26(2):167-73.
1998: Valérie M-A Ducros; Andrzej M Brzozowski; Keith S Wilson; SH Brown; P Ostergaard; P Schneider; DS Yaver; A H Pedersen; Gideon J Davies
Crystal structure of the type-2 Cu depleted laccase from Coprinus cinereus at 2.2 A resolution.
Nature structural biology 1998;5(4):310-6.
1998: Gideon J Davies; M Dauter; Andrzej M Brzozowski; Mads Eskelund Bjørnvad; Kim Vilbour Andersen; Martin Schülein
Structure of the Bacillus agaradherans family 5 endoglucanase at 1.6 A and its cellobiose complex at 2.0 A resolution.
Biochemistry 1998;37(7):1926-32.
1997: Gerlind Sulzenbacher; François Shareck; Rolf Morosoli; Claude Dupont; Gideon J Davies
The Streptomyces lividans family 12 endoglucanase: construction of the catalytic cre, expression, and X-ray structure at 1.75 A resolution.
Biochemistry 1997;36(51):16032-9.
1997: Sophie Drouillard; Sylvie Armand; Gideon J Davies; C E Vorgias; Bernard Henrissat
Serratia marcescens chitobiase is a retaining glycosidase utilizing substrate acetamido group participation.
The Biochemical journal 1997;328 ( Pt 3)():945-9.
1997: Gideon J Davies; Valérie M-A Ducros; Richard J Lewis; Torben V Borchert; Martin Schülein
Oligosaccharide specificity of a family 7 endoglucanase: insertion of potential sugar-binding subsites.
Journal of biotechnology 1997;57(1-3):91-100.
1997: Andrzej M Brzozowski; Gideon J Davies
Structure of the Aspergillus oryzae alpha-amylase complexed with the inhibitor acarbose at 2.0 A resolution.
Biochemistry 1997;36(36):10837-45.
1997: Valérie M-A Ducros; Gideon J Davies; DM Lawson; Keith S Wilson; SH Brown; P Østergaard; A H Pedersen; P Schneider; DS Yaver; Andrzej M Brzozowski
Crystallization and preliminary X-ray analysis of the laccase from Coprinus cinereus.
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 5):605-7.
1997: Gerlind Sulzenbacher; Martin Schülein; Gideon J Davies
Structure of the endoglucanase I from Fusarium oxysporum: native, cellobiose, and 3,4-epoxybutyl beta-D-cellobioside-inhibited forms, at 2.3 A resolution.
Biochemistry 1997;36(19):5902-11.
1997: LF Mackenzie; Gideon J Davies; Martin Schülein; Stephen G Withers
Identification of the catalytic nucleophile of endoglucanase I from Fusarium oxysporum by mass spectrometry.
Biochemistry 1997;36(19):5893-901.
1996: Gerlind Sulzenbacher; Hugues Driguez; Bernard Henrissat; Martin Schülein; Gideon J Davies
Structure of the Fusarium oxysporum endoglucanase I with a nonhydrolyzable substrate analogue: substrate distortion gives rise to the preferred axial orientation for the leaving group.
Biochemistry 1996;35(48):15280-7.
1996: Gideon J Davies; Guy G Dodson; M H Moore; S P Tolley; Zbigniew Dauter; Keith S Wilson; G Rasmussen; Martin Schülein
Structure determination and refinement of the Humicola insolens endoglucanase V at 1.5 A resolution.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 1):7-17.
1995: Gideon J Davies; S P Tolley; Bernard Henrissat; C Hjort; Martin Schülein
Structures of oligosaccharide-bound forms of the endoglucanase V from Humicola insolens at 1.9 A resolution.
Biochemistry 1995;34(49):16210-20.
1995: Stephen John Smerdon; S Krzywda; Andrzej M Brzozowski; Gideon J Davies; Anthony J Wilkinson; A Brancaccio; F Cutruzzolá; C T Allocatelli; Maurizio Brunori; T Li
Interactions among residues CD3, E7, E10, and E11 in myoglobins: attempts to simulate the ligand-binding properties of Aplysia myoglobin.
Biochemistry 1995;34(27):8715-25.
1995: C K Smith; Gideon J Davies; Eleanor J Dodson; M H Moore
DNA-nogalamycin interactions: the crystal structure of d(TGATCA) complexed with nogalamycin.
Biochemistry 1995;34(2):415-25.
1993: S P Tolley; Gideon J Davies; M O'Shea; Mark Cockett; Andrew J P Docherty; Gillian Murphy
Crystallization and preliminary X-ray analysis of nonglycosylated tissue inhibitor of metalloproteinases-1, N30QN78Q TIMP-1.
Proteins 1993;17(4):435-7.
1993: Gideon J Davies; Guy G Dodson; Roderick E Hubbard; S P Tolley; Zbigniew Dauter; Keith S Wilson; C Hjort; J M Mikkelsen; G Rasmussen; Martin Schülein
Structure and function of endoglucanase V.
Nature 1993;365(6444):362-4.