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Michael Davies

Research Profile

Disorders

Physiology

Chemicals & Drugs

Anatomy

Genes & Molecular Sequences

Genes, Tumor Suppressor

Phenomena

Phosphorylation

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Publications

TOP 3
Wesley O Greaves; Alexander J Lazar; Kenneth D Aldape; Bedia A Barkoh; Michael A Davies; John M Galbincea; L Jeffrey Medeiros; Keyur P Patel; Shalini Verma; Hui Yao; Rajyalakshmi Luthra
Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma.
Sapna P Patel; Carol S Vaughn; Roger B Cohen; Michael A Davies; Michelle R Glass; Jeffrey R Infante; Alexander J Lazar; Ping Liu; Patricia M LoRusso; Nicholas E Papadopoulos; Kevin B Kim
Clinical responses to selumetinib (AZD6244; ARRY-142886)-based combination therapy stratified by gene mutations in patients with metastatic melanoma.
Michael A Davies; Scott Kopetz
Overcoming resistance to MAPK pathway inhibitors.

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All Publications

2013: Wesley O Greaves; Alexander J Lazar; Kenneth D Aldape; Bedia A Barkoh; Michael A Davies; John M Galbincea; L Jeffrey Medeiros; Keyur P Patel; Shalini Verma; Hui Yao; Rajyalakshmi Luthra
Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma.
The Journal of molecular diagnostics : JMD 2013;15(2):220-6.
2013: Sapna P Patel; Carol S Vaughn; Roger B Cohen; Michael A Davies; Michelle R Glass; Jeffrey R Infante; Alexander J Lazar; Ping Liu; Patricia M LoRusso; Nicholas E Papadopoulos; Kevin B Kim
Clinical responses to selumetinib (AZD6244; ARRY-142886)-based combination therapy stratified by gene mutations in patients with metastatic melanoma.
Cancer 2013;119(4):799-805.
2013: Michael A Davies; Scott Kopetz
Overcoming resistance to MAPK pathway inhibitors.
Journal of the National Cancer Institute 2013;105(1):9-10.
2012: Jinhyun Kim; Agop Y Bedikian; Michael A Davies; Jade Homsi; Patrick Hwu; Wen-Jen Hwu; Alexander J Lazar; Nicholas E Papadopoulos; Sapna P Patel; Scott E Woodman; Kevin B Kim
BRAF, NRAS and KIT sequencing analysis of spindle cell melanoma.
Journal of cutaneous pathology 2012;39(9):821-5.
2012: John A Jakob; Richard W Joseph; Kevin B Kim; Alexander Lazar; Chaan S Ng; Jessie Richard; Michelle L Rohlfs; Gladys C Alvarado; Roland L Bassett; Jonathan L Curry; Jeffrey E Gershenwald; Patrick Hwu; Michael A Davies
NRAS mutation status is an independent prognostic factor in metastatic melanoma.
Cancer 2012;118(16):4014-23.
2012: Chandrani Chattopadhyay; Michael A Davies; Suhendan Ekmekcioglu; Julie A Ellerhorst; Victoria R Greene; Elizabeth A Grimm
Association of activated c-Met with NRAS-mutated human melanomas.
International journal of cancer. Journal international du cancer 2012;131(2):E56-65.
2012: Mustafa Aziz Hatiboglu; Michael A Davies; Gregory N Fuller; Ling-Yuan Kong; Kayla Anne McEnery; Waldemar Priebe; Wei Qiao; Yongtao Wang; Jun Wei; Amy B Heimberger
The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models.
International journal of cancer. Journal international du cancer 2012;131(1):8-17.
2012: Tariq Al-Zaid; Michael A Davies; Jeremy S Ditelberg; A Hafeez Diwan; Dina lev; Raja Luthra; Victor G Prieto; Wei-Lien Wang; Alexander J Lazar
Trichilemmomas show loss of PTEN in Cowden syndrome but only rarely in sporadic tumors.
Journal of cutaneous pathology 2012;39(5):493-9.
2012: Hong Mu; Victor G Prieto; Hua Wang; Gordon B Mills; Menashe Bar-Eli; Tiffany L Calderone; Michael A Davies; jeffrey gershenwald
Lysophosphatidic acid induces lymphangiogenesis and IL-8 production in vitro in human lymphatic endothelial cells.
The American journal of pathology 2012;180(5):2170-81.
2012: Michael A Davies
The role of the PI3K-AKT pathway in melanoma.
Cancer journal (Sudbury, Mass.) 2012;18(2):142-7.
2012: Michael A Davies
Special issue on melanoma.
Cancer journal (Sudbury, Mass.) 2012;18(2):115-6.
2012: Scott E Woodman; Alexander J Lazar; Kenneth Aldape; Michael A Davies
New strategies in melanoma: molecular testing in advanced disease.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(5):1195-200.
2011: Todd D Prickett; STEVEN ROSENBERG; Katherine Stemke-Hale; Jamie K Teer; Vijay Walia; Xiaomu Wei; Isabel Cardenas-Navia; Praveen F Cherukuri; Michael A Davies; Jared Gartner; Jeffrey E Gershenwald; Jiji Jiang; Jimmy C Lin; Elliott H Margulies; Alfredo Molinolo; Yardena Samuels
Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.
Nature genetics 2011;43(11):1119-26.
2011: Xiaomu Wei; Vijay Walia; Jimmy C Lin; Jamie K Teer; Todd D Prickett; Jared Gartner; Sean Davis; Katherine Stemke-Hale; Michael A Davies; Jeffrey E Gershenwald; William Robinson; Steven Robinson; STEVEN ROSENBERG; Yardena Samuels
Exome sequencing identifies GRIN2A as frequently mutated in melanoma.
Nature genetics 2011;43(5):442-6.
2011: Michael A Davies; Ping Liu; Susan McIntyre; Kevin B Kim; Nicholas Papadopoulos; Wen-Jen Hwu; Patrick Hwu; Agop Bedikian
Prognostic factors for survival in melanoma patients with brain metastases.
Cancer 2011;117(8):1687-96.
2011: Michael A Davies; jeffrey gershenwald
Targeted therapy for melanoma: a primer.
Surgical oncology clinics of North America 2011;20(1):165-80.
2010: Michael A Davies; Y Samuels
Analysis of the genome to personalize therapy for melanoma.
Oncogene 2010;29(41):5545-55.
2010: Eun Sung Park; Rosalia Rabinovsky; Mark Carey; Bryan T. J. Hennessy; Roshan Agarwal; Wenbin Liu; Zhenlin Ju; Wanleng Deng; Yiling Lu; hyun goo woo; Sang-Bae Kim; Jae-Ho Cheong; Levi A Garraway; John N Weinstein; Gordon B Mills; Ju-Seog Lee; Michael A Davies
Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set.
Molecular cancer therapeutics 2010;9(2):257-67.
2010: Zhiyong Ding; Jiyong Liang; Jin Li; Yiling Lu; Vathsala Ariyaratna; Zhimin Lu; Michael A Davies; John K Westwick; Gordon B Mills
Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase.
PloS one 2010;5(3):e9910.
2008: Michael A Davies; Katherine Stemke-Hale; Carmen Tellez; T L Calderone; W Deng; Victor G Prieto; Alexander Lazar; jeffrey gershenwald; Gordon B Mills
A novel AKT3 mutation in melanoma tumours and cell lines.
British journal of cancer 2008;99(8):1265-8.
2002: Michael A Davies; Sun J Kim; Nila U Parikh; Zhongyun Dong; Corazon D Bucana; Gary E Gallick
Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(6):1904-14.
2002: Dimpy Koul; Samar A Jasser; Yiling Lu; Michael A Davies; Ruijun Shen; Yuexi Shi; Gordon B Mills; W K Alfred Yung
Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.
Oncogene 2002;21(15):2357-64.
2001: Dimpy Koul; R Parthasarathy; Ruijun Shen; Michael A Davies; Samar A Jasser; Chintala Shravan; Jasti Sambasiva Rao; Yi Sun; E N Benvenisite; Ta-Jen Liu; W K Alfred Yung
Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN.
Oncogene 2001;20(46):6669-78.
2001: S A Beresford; Michael A Davies; Gary E Gallick; Nicholas J Donato
Differential effects of phosphatidylinositol-3/Akt-kinase inhibition on apoptotic sensitization to cytokines in LNCaP and PCc-3 prostate cancer cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2001;21(5):313-22.
2000: Motoyoshi Tanaka; Dimpy Koul; Michael A Davies; Monica Liebert; PA Steck; H Barton Grossman
MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells.
Oncogene 2000;19(47):5406-12.
1999: Ying Lu; Y Z Lin; Ruth Lapushin; Bruce D Cuevas; Xiang Fang; S X Yu; Michael A Davies; H Khan; Tatsuro Furui; Muling Mao; R Zinner; M C Hung; PA Steck; Katherine A Siminovitch; Gordon B Mills
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.
Oncogene 1999;18(50):7034-45.
1999: Michael A Davies; Dimpy Koul; H Dhesi; R Berman; Timothy J McDonnell; David J McConkey; W K Alfred Yung; PA Steck
Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN.
Cancer research 1999;59(11):2551-6.
1998: Michael A Davies; Ying Lu; T Sano; Xiang Fang; P Tang; Ruth Lapushin; Dimpy Koul; Robert Bookstein; David Stokoe; W K Alfred Yung; Gordon B Mills; PA Steck
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.
Cancer research 1998;58(23):5285-90.