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Jean Davignon

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Hanny Wassef; Huda Salem; Alexis Baass; Simon Bissonnette; Jean Davignon; Robert Dufour; May Faraj
White adipose tissue apolipoprotein C-I secretion in relation to delayed plasma clearance of dietary fat in humans.
Jean Davignon
Pleiotropic effects of pitavastatin.
Janice Mayne; Majambu Mbikay; Teik Chye Ooi; Angela Raymond; Nabil G Seidah; Lise Bernier; Marion Cousins; Jean Davignon; Thilina Dewpura; Michel Chrétien
Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture.

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2012: Hanny Wassef; Huda Salem; Alexis Baass; Simon Bissonnette; Jean Davignon; Robert Dufour; May Faraj
White adipose tissue apolipoprotein C-I secretion in relation to delayed plasma clearance of dietary fat in humans.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(11):2785-93.
2012: Jean Davignon
Pleiotropic effects of pitavastatin.
British journal of clinical pharmacology 2012;73(4):518-35.
2011: Janice Mayne; Majambu Mbikay; Teik Chye Ooi; Angela Raymond; Nabil G Seidah; Lise Bernier; Marion Cousins; Jean Davignon; Thilina Dewpura; Michel Chrétien
Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture.
Clinical chemistry 2011;57(10):1415-23.
2010: Jean Davignon; Geneviève Dubuc; Nabil G Seidah
The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis.
Current atherosclerosis reports 2010;12(5):308-15.
2010: Geneviève Dubuc; Michel Tremblay; Guillaume Paré; Hélène Jacques; Josée Hamelin; Suzanne Benjannet; Lucie Boulet; Jacques Genest; Lise Bernier; Nabil G Seidah; Jean Davignon
A new method for measurement of total plasma PCSK9: clinical applications.
Journal of lipid research 2010;51(1):140-9.
2009: Alexis Baass; Hanny Wassef; Michel Tremblay; Lise Bernier; Robert Dufour; Jean Davignon
Characterization of a new LCAT mutation causing familial LCAT deficiency (FLD) and the role of APOE as a modifier gene of the FLD phenotype.
Atherosclerosis 2009;207(2):452-7.
2009: Steven A Grover; Mohammed Kaouache; Lawrence Joseph; Philip Barter; Jean Davignon
Evaluating the incremental benefits of raising high-density lipoprotein cholesterol levels during lipid therapy after adjustment for the reductions in other blood lipid levels.
Archives of internal medicine 2009;169(19):1775-80.
2009: Alexis Baass; Geneviève Dubuc; Michel Tremblay; Edgard E Delvin; Jennifer O'Loughlin; Emile Levy; Jean Davignon; Marie Lambert
Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents.
Clinical chemistry 2009;55(9):1637-45.
2009: Jean-François Carmel; Evelyne Tarnus; Jeffrey S Cohn; Emmanuel Bourdon; Jean Davignon; Lise Bernier
High expression of apolipoprotein E impairs lipid storage and promotes cell proliferation in human adipocytes.
Journal of cellular biochemistry 2009;106(4):608-17.
2008: Ahmed Zaid; Anna Roubtsova; Rachid Essalmani; Jadwiga Marcinkiewicz; Ann Chamberland; Josée Hamelin; Michel Tremblay; Hélène Jacques; Weijun Jin; Jean Davignon; Nabil G Seidah; Annik Prat
Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration.
Hepatology (Baltimore, Md.) 2008;48(2):646-54.
2008: Lise Bernier; Lucie Boulet; Madeleine Roy; Robert Dufour; François Larivière; Jean Davignon
Two new large deletions in the low density lipoprotein receptor (LDLR) gene not revealed by PCR-based molecular diagnosis of familial hypercholesterolemia.
Atherosclerosis 2008;197(1):118-24.
2007: Aloys De Windt; MYRIAM RAI; Lise Bernier; Karin M Thelen; Juhani T Soini; Chantal Lefebvre; Satyan Chintawar; Jacques Lavigne; Lilli Saarinen; Leena Kytömäki; Jon Scott Munzer; Dieter Lütjohann; Massimo Pandolfo; Jean Davignon; Nabil G Seidah; Reijo Laaksonen
Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells.
DNA and cell biology 2007;26(11):765-72.
2007: Aloys De Windt; MYRIAM RAI; Leena Kytömäki; Karin M Thelen; Dieter Lütjohann; Lise Bernier; Jean Davignon; Juhani T Soini; Massimo Pandolfo; Reijo Laaksonen
Gene set enrichment analyses revealed several affected pathways in Niemann-pick disease type C fibroblasts.
DNA and cell biology 2007;26(9):665-71.
2007: Olaf Schouten; Sanne E Hoeks; Gijs M J M Welten; Jean Davignon; John J P Kastelein; Radosav Vidakovic; Harm H H Feringa; Martin Dunkelgrun; Ron T van Domburg; Jeroen J Bax; Don Poldermans
Effect of statin withdrawal on frequency of cardiac events after vascular surgery.
The American journal of cardiology 2007;100(2):316-20.
2007: Denis Blache; Suzanne Lussier-Cacan; Jacques Gagnon; Arthur S Leon; D C Rao; James Skinner; Jack H Wilmore; Tuomo Rankinen; Claude Bouchard; Jean Davignon
Effect of exercise training on in vitro LDL oxidation and free radical-induced hemolysis: the HERITAGE Family Study.
Antioxidants & redox signaling 2007;9(1):123-30.
2006: Tomohiro Okura; Tuomo Rankinen; Jacques Gagnon; Suzanne Lussier-Cacan; Jean Davignon; Arthur S Leon; Dabeeru C Rao; James Skinner; Jack H Wilmore; Claude Bouchard
Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study.
European journal of applied physiology 2006;98(4):394-401.
2006: Emmanuel Bourdon; Nadine Loreau; Laurent Lagrost; Jean Davignon; Lise Bernier; Denis Blache
Differential effects of oxidized LDL on apolipoprotein AI and B synthesis in HepG2 cells.
Free radical biology & medicine 2006;41(5):786-96.
2006: Steven E Nissen; Stephen J Nicholls; Ilke Sipahi; Peter Libby; Joel S Raichlen; Christie M Ballantyne; Jean Davignon; Raimund Erbel; Jean-Charles Fruchart; Jean-Claude Tardif; Paul Schoenhagen; Tim Crowe; Valerie A Cain; Kathy Wolski; Marlene Goormastic; E Murat Tuzcu
Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial.
JAMA : the journal of the American Medical Association 2006;295(13):1556-65.
2006: Crina Solomon; Lise Bernier; Lucie Germain; Robert Dufour; Jean Davignon
Severe oily ichthyosis in monozygotic twins mimicking Chanarin-Dorfman syndrome but not associated with a mutation of the CGI58 gene.
Archives of dermatology 2006;142(3):402-3.
2005: Chantal Bourgault; Jean Davignon; George Fodor; Claude Gagné; Daniel Gaudet; Jacques Genest; Marc-Andre Lavoie; Lawrence Leiter; Ruth McPherson; Martin Sénécal; Michael A Marentette; Rolf J Sebaldt
Statin therapy in Canadian patients with hypercholesterolemia: the Canadian Lipid Study -- Observational (CALIPSO).
The Canadian journal of cardiology 2005;21(13):1187-93.
2005: Catherine Bouchard; Geneviève Dubuc; Jean Davignon; Lise Bernier; Jeffrey S Cohn
Post-transcriptional regulation of apoC-I synthesis and secretion in human HepG2 cells.
Atherosclerosis 2005;178(2):257-64.
2005: Jean Davignon
Apolipoprotein E and atherosclerosis: beyond lipid effect.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(2):267-9.
2005: Jean Davignon; Lawrence A Leiter
Ongoing clinical trials of the pleiotropic effects of statins.
Vascular health and risk management 2005;1(1):29-40.
2004: Hanny Wassef; Lise Bernier; Jean Davignon; Jeffrey S Cohn
Synthesis and secretion of apoC-I and apoE during maturation of human SW872 liposarcoma cells.
The Journal of nutrition 2004;134(11):2935-41.
2004: Jeffrey S Cohn; Michel Tremblay; Rami Batal; Hélène Jacques; Claudia Rodriguez; George Steiner; Orval Mamer; Jean Davignon
Increased apoC-III production is a characteristic feature of patients with hypertriglyceridemia.
Atherosclerosis 2004;177(1):137-45.
2004: Jeffrey S Cohn; Bruce W Patterson; Kristine D Uffelman; Jean Davignon; George Steiner
Rate of production of plasma and very-low-density lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensitivity.
The Journal of clinical endocrinology and metabolism 2004;89(8):3949-55.
2004: Jean Davignon; Robert Jacob; R Preston Mason
The antioxidant effects of statins.
Coronary artery disease 2004;15(5):251-8.
2004: Jean Davignon
Emphasis on pleiotropic effects, a new paradigm shift?
Coronary artery disease 2004;15(5):223-5.
2004: Geneviève Dubuc; Ann Chamberland; Hanny Wassef; Jean Davignon; Nabil G Seidah; Lise Bernier; Annik Prat
Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(8):1454-9.
2004: Jeffrey S Cohn; Claudia Rodriguez; Hélène Jacques; Michel Tremblay; Jean Davignon
Storage of human plasma samples leads to alterations in the lipoprotein distribution of apoC-III and apoE.
Journal of lipid research 2004;45(8):1572-9.
2004: Jean Davignon
Beneficial cardiovascular pleiotropic effects of statins.
Circulation 2004;109(23 Suppl 1):III39-43.
2004: Jean Davignon; Peter Ganz
Role of endothelial dysfunction in atherosclerosis.
Circulation 2004;109(23 Suppl 1):III27-32.
2004: Jean Davignon
The cardioprotective effects of statins.
Current atherosclerosis reports 2004;6(1):27-35.
2003: Laurence Mabile; Chantal Lefebvre; Jacques Lavigne; Lucie Boulet; Jean Davignon; Suzanne Lussier-Cacan; Lise Bernier
Secreted apolipoprotein E reduces macrophage-mediated LDL oxidation in an isoform-dependent way.
Journal of cellular biochemistry 2003;90(4):766-76.
2003: Katherine Cianflone; Steve Phélis; Jean Davignon; Brian M Gilfix
ApoE phenotype influences plasma ASP in hyperapoB subjects.
Atherosclerosis 2003;170(2):285-91.
2003: Jeffrey S Cohn; Rami Batal; Michel Tremblay; Hélène Jacques; Lyne Veilleux; Claudia Rodriguez; Orval Mamer; Jean Davignon
Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans: in vivo evidence for a link between HDL apoC-III and apoA-I metabolism.
Journal of lipid research 2003;44(10):1976-83.
2003: Lucia Nassi Castilho; Ann Chamberland; Lucie Boulet; Jean Davignon; Jeffrey S Cohn; Lise Bernier
Effect of atorvastatin on ApoE and ApoC-I synthesis and secretion by THP-1 macrophages.
Journal of cardiovascular pharmacology 2003;42(2):251-7.
2003: Jeffrey S Cohn; Michel Tremblay; Lucie Boulet; Hélène Jacques; Jean Davignon; Madeleine Roy; Lise Bernier
Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism.
Atherosclerosis 2003;169(1):63-70.
2003: Xingyu Wang; Vinita Chauhan; Anh T Nguyen; Joshua Schultz; Jean Davignon; Stephen G Young; Jan Boren; Thomas L Innerarity; Hui Rutai; Ross W Milne
Immunochemical evidence that human apoB differs when expressed in rodent versus human cells.
Journal of lipid research 2003;44(3):547-53.
2003: Alain Piolot; Denis Blache; Lucie Boulet; Louis Jacques Fortin; Denise Dubreuil; Caroline Marcoux; Jean Davignon; Suzanne Lussier-Cacan
Effect of fish oil on LDL oxidation and plasma homocysteine concentrations in health.
The Journal of laboratory and clinical medicine 2003;141(1):41-9.
2002: Jeffrey S Cohn; Michel Tremblay; Rami Batal; Hélène Jacques; Lyne Veilleux; Claudia Rodriguez; Lise Bernier; Orval Mamer; Jean Davignon
Plasma kinetics of VLDL and HDL apoC-I in normolipidemic and hypertriglyceridemic subjects.
Journal of lipid research 2002;43(10):1680-7.
2002: Jeffrey S Cohn; Michel Tremblay; Rami Batal; Hélène Jacques; Lyne Veilleux; Claudia Rodriguez; Hugh Barrett; Denise Dubreuil; Madeleine Roy; Lise Bernier; Orval Mamer; Jean Davignon
Effect of atorvastatin on plasma apoE metabolism in patients with combined hyperlipidemia.
Journal of lipid research 2002;43(9):1464-71.
2001: Laurence Mabile; A Piolot; Lucie Boulet; Louis Jacques Fortin; N Doyle; Claudia Rodriguez; Jean Davignon; Denis Blache; Suzanne Lussier-Cacan
Moderate intake of n-3 fatty acids is associated with stable erythrocyte resistance to oxidative stress in hypertriglyceridemic subjects.
The American journal of clinical nutrition 2001;74(4):449-56.
2001: Larbi Krimbou; Michel Marcil; Jean Davignon; Jacques Genest
Interaction of lecithin:cholesterol acyltransferase (LCAT).alpha 2-macroglobulin complex with low density lipoprotein receptor-related protein (LRP). Evidence for an alpha 2-macroglobulin/LRP receptor-mediated system participating in LCAT clearance.
The Journal of biological chemistry 2001;276(35):33241-8.
2001: William Insull; Michael J Koren; Jean Davignon; D Sprecher; Helmut Schrott; L M Keilson; A S Brown; Carlos A Dujovne; Michael H Davidson; Richard McLain; Therese Heinonen
Efficacy and short-term safety of a new ACAT inhibitor, avasimibe, on lipids, lipoproteins, and apolipoproteins, in patients with combined hyperlipidemia.
Atherosclerosis 2001;157(1):137-44.
2001: T Grewal; E Priceputu; Jean Davignon; Lise Bernier
Identification of a gamma-interferon-responsive element in the promoter of the human macrophage scavenger receptor A gene.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(5):825-31.
2001: Jean Davignon; Laurence Mabile
[Mechanisms of action of statins and their pleiotropic effects].
Annales d'endocrinologie 2001;62(1 Pt 2):101-12.
2001: Jean Davignon
Advances in lipid-lowering therapy in atherosclerosis.
Advances in experimental medicine and biology 2001;498():49-58.
2001: Caroline Marcoux; Michel Tremblay; A Fredenrich; Jean Davignon; Jeffrey S Cohn
Lipoprotein distribution of apolipoprotein C-III and its relationship to the presence in plasma of triglyceride-rich remnant lipoproteins.
Metabolism: clinical and experimental 2001;50(1):112-9.
2000: Emmanuel Bourdon; Nadine Loreau; Jean Davignon; Lise Bernier; Denis Blache
Involvement of oxysterols and lysophosphatidylcholine in the oxidized LDL-induced impairment of serum albumin synthesis by HEPG2 cells.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(12):2643-50.
2000: Caroline Marcoux; P N Hopkins; T Wang; ET Leary; K Nakajima; Jean Davignon; Jeffrey S Cohn
Remnant-like particle cholesterol and triglyceride levels of hypertriglyceridemic patients in the fed and fasted state.
Journal of lipid research 2000;41(9):1428-36.
2000: Rami Batal; Michel Tremblay; Hugh Barrett; Hélène Jacques; A Fredenrich; Orval Mamer; Jean Davignon; Jeffrey S Cohn
Plasma kinetics of apoC-III and apoE in normolipidemic and hypertriglyceridemic subjects.
Journal of lipid research 2000;41(5):706-18.
2000: Rafael Carmena; Madeleine Roy; G Roederer; A Minnich; Jean Davignon
Coexisting dysbetalipoproteinemia and familial hypercholesterolemia. Clinical and laboratory observations.
Atherosclerosis 2000;148(1):113-24.
1999: Jean Davignon; R Laaksonen
Low-density lipoprotein-independent effects of statins.
Current opinion in lipidology 1999;10(6):543-59.
1999: Suzanne Lussier-Cacan; Marianne Xhignesse; A M Kessling; Jean Davignon; Charles F Sing
Sources of variation in plasma lipid and lipoprotein traits in a sample selected for health.
American journal of epidemiology 1999;150(11):1229-37.
1999: Jeffrey S Cohn; Caroline Marcoux; Jean Davignon
Detection, quantification, and characterization of potentially atherogenic triglyceride-rich remnant lipoproteins.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(10):2474-86.
1999: Jean Davignon; Jeffrey S Cohn; Laurence Mabile; Lise Bernier
Apolipoprotein E and atherosclerosis: insight from animal and human studies.
Clinica chimica acta; international journal of clinical chemistry 1999;286(1-2):115-43.
1999: L Gesquière; Nadine Loreau; A Minnich; Jean Davignon; Denis Blache
Oxidative stress leads to cholesterol accumulation in vascular smooth muscle cells.
Free radical biology & medicine 1999;27(1-2):134-45.
1999: Caroline Marcoux; Michel Tremblay; K Nakajima; Jean Davignon; Jeffrey S Cohn
Characterization of remnant-like particles isolated by immunoaffinity gel from the plasma of type III and type IV hyperlipoproteinemic patients.
Journal of lipid research 1999;40(4):636-47.
1998: Larbi Krimbou; Michel Tremblay; Jean Davignon; Jeffrey S Cohn
Association of apolipoprotein E with alpha2-macroglobulin in human plasma.
Journal of lipid research 1998;39(12):2373-86.
1998: Jean Davignon; Jacques Genest
Genetics of lipoprotein disorders.
Endocrinology and metabolism clinics of North America 1998;27(3):521-50.
1998: Jean Davignon; M Hanefeld; N Nakaya; Donald B Hunninghake; William Insull; Leiv Ose
Clinical efficacy and safety of cerivastatin: summary of pivotal phase IIb/III studies.
The American journal of cardiology 1998;82(4B):32J-39J.
1998: Caroline Marcoux; Michel Tremblay; A Fredenrich; Hélène Jacques; Larbi Krimbou; K Nakajima; Jean Davignon; Jeffrey S Cohn
Plasma remnant-like particle lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects.
Atherosclerosis 1998;139(1):161-71.
1998: T Grewal; M Boudreau; Madeleine Roy; Ann Chamberland; Chantal Lefebvre; Jacques Lavigne; Jean Davignon; A Minnich
Expression of gamma-IFN responsive genes in scavenger receptor over-expressing monocytes is associated with xanthomatosis.
Atherosclerosis 1998;138(2):335-45.
1998: Jean Davignon
Advances in drug treatment of dyslipidemia: focus on atorvastatin.
The Canadian journal of cardiology 1998;14 Suppl B():28B-38B.
1998: Jean Davignon; Thomas A Pearson
Beyond LDL-cholesterol: can further reductions in CAD risk be achieved by considering triglycerides?
The Canadian journal of cardiology 1998;14 Suppl B():2B.
1998: A Minnich; J Baloukas; G Roederer; Suzanne Lussier-Cacan; Jean Davignon; Jacques Genest
Lipoprotein lipase gene mutations in coronary artery disease.
The Canadian journal of cardiology 1998;14(5):711-6.
1998: Jean Davignon
Methods and endpoint issues in clinical development of lipid-acting agents with pleiotropic effects.
The American journal of cardiology 1998;81(8A):17F-24F.
1998: Larbi Krimbou; Michel Tremblay; Hélène Jacques; Jean Davignon; Jeffrey S Cohn
In vitro factors affecting the concentration of gamma-LpE (gamma-LpE) in human plasma.
Journal of lipid research 1998;39(4):861-72.
1998: Rami Batal; Michel Tremblay; Larbi Krimbou; Orval Mamer; Jean Davignon; Jacques Genest; Jeffrey S Cohn
Familial HDL deficiency characterized by hypercatabolism of mature apoA-I but not proapoA-I.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(4):655-64.
1997: Jeffrey S Cohn; LM Giroux; Louis Jacques Fortin; Jean Davignon
Prevalence of double pre-beta lipoproteinemia in hyperlipidemic patients is influenced by gender, menopausal status, and ApoE phenotype.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2630-7.
1997: T C Ooi; T Heinonen; Petar Alaupovic; Jean Davignon; Lawrence Leiter; Paul J Lupien; A D Sniderman; Meng Tan; G Tremblay; A Sorisky; L Shurzinske; D M Black
Efficacy and safety of a new hydroxymethylglutaryl-coenzyme A reductase inhibitor, atorvastatin, in patients with combined hyperlipidemia: comparison with fenofibrate.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(9):1793-9.
1997: LM Giroux; Jeffrey S Cohn; J LaMarre; Jean Davignon
Pseudo type III dyslipoproteinemia is associated with normal fibroblast lipoprotein receptor activity.
Atherosclerosis 1997;132(1):85-94.
1997: Marie-Claude Vohl; Sital Moorjani; Madeleine Roy; Daniel Gaudet; A L Torres; A Minnich; Claude Gagné; Gérald Tremblay; M Lambert; Jean Bergeron; Patrick Couture; Patrice Perron; S Blaichman; LD Brun; Jean Davignon; Paul J Lupien; Jean-Pierre Després
Geographic distribution of French-Canadian low-density lipoprotein receptor gene mutations in the Province of Quebec.
Clinical genetics 1997;52(1):1-6.
1997: A Fredenrich; LM Giroux; Michel Tremblay; Larbi Krimbou; Jean Davignon; Jeffrey S Cohn
Plasma lipoprotein distribution of apoC-III in normolipidemic and hypertriglyceridemic subjects: comparison of the apoC-III to apoE ratio in different lipoprotein fractions.
Journal of lipid research 1997;38(7):1421-32.
1997: Caroline Marcoux; Suzanne Lussier-Cacan; Jean Davignon; Jeffrey S Cohn
Association of Lp(a) rather than integrally-bound apo(a) with triglyceride-rich lipoproteins of human subjects.
Biochimica et biophysica acta 1997;1346(3):261-74.
1997: Emile Levy; A Minnich; S L Cacan; Louise Thibault; LM Giroux; Jean Davignon; M Lambert
Association of an exon 3 mutation (Trp66-->Gly) of the LDL receptor with variable expression of familial hypercholesterolemia in a French Canadian family.
Biochemical and molecular medicine 1997;60(1):59-69.
1997: Larbi Krimbou; Michel Tremblay; Jean Davignon; Jeffrey S Cohn
Characterization of human plasma apolipoprotein E-containing lipoproteins in the high density lipoprotein size range: focus on pre-beta1-LpE, pre-beta2-LpE, and alpha-LpE.
Journal of lipid research 1997;38(1):35-48.
1996: Jean Davignon
A lipid clinic associated with a research laboratory working on dyslipoproteinemias and atherosclerosis.
The Canadian journal of cardiology 1996;12(10):885-90.
1996: Suzanne Lussier-Cacan; M Xhignesse; A Piolot; J Selhub; Jean Davignon; J Genest
Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits.
The American journal of clinical nutrition 1996;64(4):587-93.
1996: Jean Davignon; Jeffrey S Cohn
Triglycerides: a risk factor for coronary heart disease.
Atherosclerosis 1996;124 Suppl():S57-64.
1996: C Giry; LM Giroux; M Roy; Jean Davignon; A Minnich
Characterization of inherited scavenger receptor overexpression and abnormal macrophage phenotype in a normolipidemic subject with planar xanthomas.
Journal of lipid research 1996;37(7):1422-35.
1996: Daniel Guillaume; P Bertrand; Doris Dea; Jean Davignon; Judes Poirier
Apolipoprotein E and low-density lipoprotein binding and internalization in primary cultures of rat astrocytes: isoform-specific alterations.
Journal of neurochemistry 1996;66(6):2410-8.
1996: Michel Marcil; Betsie Boucher; E Gagné; Jean Davignon; M Hayden; J Genest
Lack of association of the apolipoprotein A-I-C-III-A-IV gene XmnI and SstI polymorphisms and of the lipoprotein lipase gene mutations in familial combined hyperlipoproteinemia in French Canadian subjects.
Journal of lipid research 1996;37(2):309-19.
1996: C Bétard; A M Kessling; M Roy; Jean Davignon
Influence of genetic variability in the nondeletion LDL-receptor allele on phenotypic variation in French-Canadian familial hypercholesterolemia heterozygotes sharing a 'null' LDL-receptor gene defect.
Atherosclerosis 1996;119(1):43-55.
1996: Jeffrey S Cohn; Michel Tremblay; M Amiot; D Bouthillier; M Roy; J Genest; Jean Davignon
Plasma concentration of apolipoprotein E in intermediate-sized remnant-like lipoproteins in normolipidemic and hyperlipidemic subjects.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(1):149-59.
1996: Rafael Carmena; Suzanne Lussier-Cacan; M Roy; A Minnich; Arno Lingenhel; Florian Kronenberg; Jean Davignon
Lp(a) levels and atherosclerotic vascular disease in a sample of patients with familial hypercholesterolemia sharing the same gene defect.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(1):129-36.
1995: J Poirier; A Minnich; Jean Davignon
Apolipoprotein E, synaptic plasticity and Alzheimer's disease.
Annals of medicine 1995;27(6):663-70.
1995: C Sass; LM Giroux; Suzanne Lussier-Cacan; Jean Davignon; A Minnich
Unexpected consequences of deletion of the first two repeats of the ligand-binding domain from the low density lipoprotein receptor. Evidence from a human mutation.
The Journal of biological chemistry 1995;270(42):25166-71.
1995: A Minnich; G DeLangavant; J Lavigne; G Roederer; Suzanne Lussier-Cacan; Jean Davignon
G-->A substitution at position -75 of the apolipoprotein A-I gene promoter. Evidence against a direct effect on HDL cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(10):1740-5.
1995: J Ferrières; J Lambert; Suzanne Lussier-Cacan; Jean Davignon
Coronary artery disease in heterozygous familial hypercholesterolemia patients with the same LDL receptor gene mutation.
Circulation 1995;92(3):290-5.
1995: HANNIA CAMPOS; G O Roederer; S Lussier-Cacan; Jean Davignon; R M Krauss
Predominance of large LDL and reduced HDL2 cholesterol in normolipidemic men with coronary artery disease.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(8):1043-8.
1995: Michel Marcil; Betsie Boucher; Larbi Krimbou; B C Solymoss; Jean Davignon; J Frohlich; J Genest
Severe familial HDL deficiency in French-Canadian kindreds. Clinical, biochemical, and molecular characterization.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(8):1015-24.
1995: C Sass; LM Giroux; Y Ma; M Roy; J Lavigne; Suzanne Lussier-Cacan; Jean Davignon; A Minnich
Evidence for a cholesterol-lowering gene in a French-Canadian kindred with familial hypercholesterolemia.
Human genetics 1995;96(1):21-6.
1995: K Dalery; Suzanne Lussier-Cacan; J Selhub; Jean Davignon; Y Latour; J Genest
Homocysteine and coronary artery disease in French Canadian subjects: relation with vitamins B12, B6, pyridoxal phosphate, and folate.
The American journal of cardiology 1995;75(16):1107-11.
1995: A Minnich; M Roy; A Chamberland; J Lavigne; Jean Davignon
New methods for rapid detection of low-density lipoprotein receptor and apolipoprotein B gene mutations causing familial hypercholesterolemia.
Clinical biochemistry 1995;28(3):277-84.
1995: S McNicoll; Y Latour; C Rondeau; D Bouthillier; Jean Davignon; J Genest
Cardiovascular risk factors and lipoprotein profile in French Canadians with premature CAD: impact of the National Cholesterol Education Program II.
The Canadian journal of cardiology 1995;11(2):109-16.
1995: A Minnich; Karl H Weisgraber; Yvonne Newhouse; L M Dong; Louis Jacques Fortin; M Tremblay; Jean Davignon
Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3' (Arg136-->His): association with mild dyslipidemia and double pre-beta very low density lipoproteins.
Journal of lipid research 1995;36(1):57-66.
1995: A Minnich; A Kessling; M Roy; C Giry; G DeLangavant; J Lavigne; Suzanne Lussier-Cacan; Jean Davignon
Prevalence of alleles encoding defective lipoprotein lipase in hypertriglyceridemic patients of French Canadian descent.
Journal of lipid research 1995;36(1):117-24.
1994: J Ferrières; Charles F Sing; M Roy; Jean Davignon; Suzanne Lussier-Cacan
Apolipoprotein E polymorphism and heterozygous familial hypercholesterolemia. Sex-specific effects.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(10):1553-60.
1994: L Karayan; S Qiu; C Betard; R Dufour; G Roederer; A Minnich; Jean Davignon; J Genest
Response to HMG CoA reductase inhibitors in heterozygous familial hypercholesterolemia due to the 10-kb deletion ("French Canadian mutation") of the LDL receptor gene.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(8):1258-63.
1994: J Dallongeville; N Leboeuf; Charles Blais; J Touchette; Nicole Gervais; Jean Davignon
Short-term response to dietary counseling of hyperlipidemic outpatients of a lipid clinic.
Journal of the American Dietetic Association 1994;94(6):616-21.
1994: M Naruszewicze; LM Giroux; Jean Davignon
Oxidative modification of Lp(a) causes changes in the structure and biological properties of apo(a).
Chemistry and physics of lipids 1994;67-68():167-74.
1993: Suzanne Lussier-Cacan; S Dubreuil-Quidoz; G Roederer; N Leboeuf; L Boulet; G C de Langavant; Jean Davignon; M Naruszewicz
Influence of probucol on enhanced LDL oxidation after fish oil treatment of hypertriglyceridemic patients.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(12):1790-7.
1993: Jean Davignon; M Roy
Familial hypercholesterolemia in French-Canadians: taking advantage of the presence of a "founder effect".
The American journal of cardiology 1993;72(10):6D-10D.
1993: Rafael Carmena; G Roederer; H Mailloux; Suzanne Lussier-Cacan; Jean Davignon
The response to lovastatin treatment in patients with heterozygous familial hypercholesterolemia is modulated by apolipoprotein E polymorphism.
Metabolism: clinical and experimental 1993;42(7):895-901.
1993: E Selinger; J Dallongeville; Jean Davignon
Apolipoprotein(a) is present in the triglyceride-rich fraction in type IV hypertriglyceridemia.
Clinical biochemistry 1993;26(1):59-64.
1993: LM Giroux; Jean Davignon; M Naruszewicz
Simvastatin inhibits the oxidation of low-density lipoproteins by activated human monocyte-derived macrophages.
Biochimica et biophysica acta 1993;1165(3):335-8.
1992: M Naruszewicz; E Selinger; R Dufour; Jean Davignon
Probucol protects lipoprotein (a) against oxidative modification.
Metabolism: clinical and experimental 1992;41(11):1225-8.
1992: M Naruszewicz; E Selinger; Jean Davignon
Oxidative modification of lipoprotein(a) and the effect of beta-carotene.
Metabolism: clinical and experimental 1992;41(11):1215-24.
1992: Jean Davignon; M Montigny; R Dufour
HMG-CoA reductase inhibitors: a look back and a look ahead.
The Canadian journal of cardiology 1992;8(8):843-64.
1992: J Dallongeville; E Selinger; Jean Davignon; Suzanne Lussier-Cacan
Fish-oil supplementation reduces Ip(a) concentrations in type III dysbetalipoproteinemia.
Clinical chemistry 1992;38(8 Pt 1):1510-1.
1992: Jean Davignon; R Dufour; M Roy; C Bétard; Y Ma; S Ouellette; L Boulet; Suzanne Lussier-Cacan
Phenotypic heterogeneity associated with defective apolipoprotein B-100 and occurrence of the familial hypercholesterolemia phenotype in the absence of an LDL-receptor defect within a Canadian kindred.
European journal of epidemiology 1992;8 Suppl 1():10-7.
1992: D Blache; D Bouthillier; Jean Davignon
Acute influence of smoking on platelet behaviour, endothelium and plasma lipids and normalization by aspirin.
Atherosclerosis 1992;93(3):179-88.
1992: J Dallongeville; Suzanne Lussier-Cacan; Jean Davignon
Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis.
Journal of lipid research 1992;33(4):447-54.
1992: R McPherson; J Bedard; P Connelly; G Curnew; Jean Davignon; D Echenberg; P Lavin; L Leiter; J Lenis; M McQueen
Comparison of the short-term efficacy and tolerability of lovastatin and pravastatin in the management of primary hypercholesterolemia.
Clinical therapeutics 1992;14(2):276-91.
1992: C Bétard; A M Kessling; M Roy; A Chamberland; Suzanne Lussier-Cacan; Jean Davignon
Molecular genetic evidence for a founder effect in familial hypercholesterolemia among French Canadians.
Human genetics 1992;88(5):529-36.
1992: J Dallongeville; Jean Davignon; Suzanne Lussier-Cacan
ACAT activity in freshly isolated human mononuclear cell homogenates from hyperlipidemic subjects.
Metabolism: clinical and experimental 1992;41(2):154-9.
1992: A Kessling; S Ouellette; O Bouffard; A Chamberland; C Bétard; E Selinger; M Xhignesse; Suzanne Lussier-Cacan; Jean Davignon
Patterns of association between genetic variability in apolipoprotein (apo) B, apo AI-CIII-AIV, and cholesterol ester transfer protein gene regions and quantitative variation in lipid and lipoprotein traits: influence of gender and exogenous hormones.
American journal of human genetics 1992;50(1):92-106.
1991: G Luc; J M Bard; Suzanne Lussier-Cacan; D Bouthillier; H J Parra; Jean-Charles Fruchart; Jean Davignon
High-density lipoprotein particles in octogenarians.
Metabolism: clinical and experimental 1991;40(12):1238-43.
1991: P Bielmann; G Leduc; G Thibault; J Lepage; Jean Davignon
Effects of chlorthalidone and metoprolol alone or in combination (logroton) on blood pressure, lipids, lipoproteins and circulating plasma ANF levels in essential hypertension.
International journal of clinical pharmacology, therapy, and toxicology 1991;29(12):479-85.
1991: Suzanne Lussier-Cacan; M Xhignesse; J L Desmarais; Jean Davignon; M E Kafrissen; A Chapdelaine
Cyclic fluctuations in human serum lipid and apolipoprotein levels during the normal menstrual cycle: comparison with changes occurring during oral contraceptive therapy.
Metabolism: clinical and experimental 1991;40(8):849-54.
1991: J Dallongeville; L Boulet; Jean Davignon; Suzanne Lussier-Cacan
Fish oil supplementation reduces beta-very low density lipoprotein in type III dysbetalipoproteinemia.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(4):864-71.
1991: M Xhignesse; Suzanne Lussier-Cacan; Charles F Sing; A M Kessling; Jean Davignon
Influences of common variants of apolipoprotein E on measures of lipid metabolism in a sample selected for health.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(4):1100-10.
1991: F Mailly; Chun-Fang Xu; M Xhignesse; Suzanne Lussier-Cacan; Philippa J Talmud; Jean Davignon; Steve E Humphries; A C Nestruck
Characterization of a new apolipoprotein E5 variant detected in two French-Canadian subjects.
Journal of lipid research 1991;32(4):613-20.
1991: Jean Davignon; J Dallongeville; G Roederer; M Roy; Jean-Charles Fruchart; A M Kessling; D Bouthillier; Suzanne Lussier-Cacan
A phenocopy of type III dysbetalipoproteinemia occurring in a candidate family for a putative apo E receptor defect.
Annals of medicine 1991;23(2):161-7.
1991: J Dallongeville; M Roy; N Leboeuf; M Xhignesse; Jean Davignon; Suzanne Lussier-Cacan
Apolipoprotein E polymorphism association with lipoprotein profile in endogenous hypertriglyceridemia and familial hypercholesterolemia.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(2):272-8.
1991: Jean Davignon
Familial hypercholesterolemia: a treatable lethal disease.
The Canadian journal of cardiology 1991;7(1):VI-VII.
1990: Thomas L Innerarity; Robert W Mahley; Karl H Weisgraber; Thomas P Bersot; R M Krauss; Gloria Lena Vega; Scott M Grundy; W Friedl; Jean Davignon; B J McCarthy
Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.
Journal of lipid research 1990;31(8):1337-49.
1990: P Fugère; R K Percival-Smith; Suzanne Lussier-Cacan; Jean Davignon; D Farquhar
Cyproterone acetate/ethinyl estradiol in the treatment of acne. A comparative dose-response study of the estrogen component.
Contraception 1990;42(2):225-34.
1990: P Bielmann; G Leduc; J Gutkowska; Jean Davignon
Effects of ketanserin on lipids, lipoproteins, and plasma atrial natriuretic factor in patients with essential hypertension.
Journal of clinical pharmacology 1990;30(5):438-43.
1990: F Mailly; Jean Davignon; A C Nestruck
Analytical isoelectric focusing with immobilized pH gradients of human apolipoprotein E from very low density lipoproteins and total plasma.
Journal of lipid research 1990;31(1):149-55.
1990: Suzanne Lussier-Cacan; A C Nestruck; H Arslanian; M Xhignesse; Jean Davignon; M E Kafrissen; A Chapdelaine
Influence of a triphasic oral contraceptive preparation on plasma lipids and lipoproteins.
Fertility and sterility 1990;53(1):28-34.
1990: J Dallongeville; Jean Davignon; Suzanne Lussier-Cacan
Relationship between plasma cholesterol levels and cholesterol esterification in isolated human mononuclear cells.
Life sciences 1990;47(25):2351-7.
1989: Y H Ma; C Bétard; M Roy; Jean Davignon; A M Kessling
Identification of a second "French Canadian" LDL receptor gene deletion and development of a rapid method to detect both deletions.
Clinical genetics 1989;36(4):219-28.
1989: Suzanne Lussier-Cacan; J M Bard; L Boulet; A C Nestruck; A M Grothé; J C Fruchart; Jean Davignon
Lipoprotein composition changes induced by fenofibrate in dysbetalipoproteinemia type III.
Atherosclerosis 1989;78(2-3):167-82.
1989: Jean Davignon; Louis Jacques Fortin; M Tremblay; D Bouthillier; A C Nestruck
An unusual band that binds hemoglobin after ultracentrifugation of hemolyzed plasma for lipoprotein separation.
Clinical chemistry 1989;35(3):495.
1989: Karl H Weisgraber; Yvonne Newhouse; J M Taylor; B Tuan; A C Nestruck; Jean Davignon; Robert W Mahley
Apolipoprotein E2(Arg158----Cys) frequency in a hyperlipidemic French-Canadian population of apolipoprotein E2/2 subjects. Determination by synthetic oligonucleotide probes.
Arteriosclerosis (Dallas, Tex.) 1989;9(1):50-7.
1988: Jean Davignon; M Xhignesse; G Roederer
Identification of the patient at risk in the physician's office and drug management of dyslipoproteinemia.
The Canadian journal of cardiology 1988;4 Suppl A():36A-47A.
1988: Jean Davignon; D Bouthillier; A C Nestruck; Charles F Sing
Apolipoprotein E polymorphism and atherosclerosis: insight from a study in octogenarians.
Transactions of the American Clinical and Climatological Association 1988;99():100-10.
1988: Jean Davignon; R E Gregg; Charles F Sing
Apolipoprotein E polymorphism and atherosclerosis.
Arteriosclerosis (Dallas, Tex.) 1988;8(1):1-21.
1987: G O Roederer; D Bouthillier; Jean Davignon
Xanthelasma palpebrarum and corneal arcus in octogenarians.
The New England journal of medicine 1987;317(27):1740.
1987: A C Nestruck; D Bouthillier; Charles F Sing; Jean Davignon
Apolipoprotein E polymorphism and plasma cholesterol response to probucol.
Metabolism: clinical and experimental 1987;36(8):743-7.
1986: Suzanne Lussier-Cacan; M Cantin; C C Roy; A D Sniderman; A C Nestruck; Jean Davignon
Tendon xanthomas associated with cholestanolosis and hyperapobetalipoproteinemia.
Clinical and investigative medicine. Médecine clinique et experimentale 1986;9(2):94-9.
1986: Jean Davignon; A C Nestruck; P Alaupovic; D Bouthillier
Severe hypoalphalipoproteinemia induced by a combination of probucol and clofibrate.
Advances in experimental medicine and biology 1986;201():111-25.
1985: Suzanne Lussier-Cacan; D Bouthillier; Jean Davignon
Apo E allele frequency in primary endogenous hypertriglyceridemia (type IV) with and without hyperapobetalipoproteinemia.
Arteriosclerosis (Dallas, Tex.) 1985;5(6):639-43.
1984: A C Nestruck; Y S Huang; K Eid; R Dufour; L Boulet; A Barbeau; Jean Davignon
Plasma cholesteryl sulfate in Friedreich's ataxia.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1984;11(4 Suppl):631-6.
1984: D Bouthillier; A C Nestruck; R Milne; Charles F Sing; A Barbeau; Jean Davignon
Distribution of apolipoprotein E phenotypes in Friedreich's ataxia.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1984;11(4 Suppl):626-30.
1983: D Blache; D Bouthillier; Jean Davignon
Simple, reproducible procedure for selective measurement of lipoprotein lipase and hepatic lipase.
Clinical chemistry 1983;29(1):154-8.
1983: Jean Davignon; D Bouthillier; R Dufour; Suzanne Lussier-Cacan
[Xanthoma and atherosclerosis in the presence of normal plasma lipids].
Annales de médecine interne 1983;134(5):483-91.
1982: D Blache; D Bouthillier; A Barbeau; Jean Davignon
Plasma lipoprotein lipase and hepatic lipase activities in Friedreich's ataxia.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1982;9(2):191-4.
1982: Jean Davignon; Suzanne Lussier-Cacan; S Dubreuil-Quidoz; J LeLorier
Experience with probucol in the treatment of hypercholesterolemia.
Artery 1982;10(1):48-55.
1980: P Bielmann; G Leduc; Jean Davignon
[Selective beta blockaders (metoprolol) versus non selective (propranolol): comparative effects on the composition of lipoprotein fractions and on blood pressure].
L'unión médicale du Canada 1980;109(12):1734-40.
1980: M Enjalbert; Suzanne Lussier-Cacan; S DuBreuil-Quidoz; J LeLorier; Jean Davignon
Usefulness of probucol in treating primary hypercholesterolemia.
Canadian Medical Association journal 1980;123(8):754-7.
1980: Jean Davignon; N Leboeuf; S Lussier-Cacan
[Nutritional aspects of managing hyperlipidemias and atherosclerosis].
L'unión médicale du Canada 1980;109(5):656-65.
1980: P Bielmann; G Leduc; M Germain; Jean Davignon
Beta-blockers and changes in lipoprotein fractions.
The New England journal of medicine 1980;302(5):298.