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Darren Davis

Research Profile

Disorders

Neovascularization, Pathologic

Chemicals & Drugs

Living Beings

Procedures

Anatomy

Tumor Cells, Cultured

Concepts & Ideas

Drug Dose Response Relationship

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Co-author Network

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Publications

TOP 3
Kevin B Kim; Omar Eton; Darren W Davis; M L Frazier; David J McConkey; A Hafeez Diwan; Nicholas E Papadopoulos; Agop Bedikian; L H Camacho; M I Ross; J N Cormier; jeffrey gershenwald; J E Lee; P F Mansfield; L A Billings; C S Ng; C Charnsangavej; Menashe Bar-Eli; Marcella M Johnson; A J Murgo; Victor G Prieto
Phase II trial of imatinib mesylate in patients with metastatic melanoma.
Carmen Tellez; Darren W Davis; Victor G Prieto; jeffrey gershenwald; Marcella M Johnson; Marya F McCarty; Menashe Bar-Eli
Quantitative analysis of melanocytic tissue array reveals inverse correlation between activator protein-2alpha and protease-activated receptor-1 expression during melanoma progression.
Aaron J Berger; Darren W Davis; Carmen Tellez; Victor G Prieto; jeffrey gershenwald; Marcella M Johnson; David L Rimm; Menashe Bar-Eli
Automated quantitative analysis of activator protein-2alpha subcellular expression in melanoma tissue microarrays correlates with survival prediction.

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All Publications

2008: Kevin B Kim; Omar Eton; Darren W Davis; M L Frazier; David J McConkey; A Hafeez Diwan; Nicholas E Papadopoulos; Agop Bedikian; L H Camacho; M I Ross; J N Cormier; jeffrey gershenwald; J E Lee; P F Mansfield; L A Billings; C S Ng; C Charnsangavej; Menashe Bar-Eli; Marcella M Johnson; A J Murgo; Victor G Prieto
Phase II trial of imatinib mesylate in patients with metastatic melanoma.
British journal of cancer 2008;99(5):734-40.
2007: Carmen Tellez; Darren W Davis; Victor G Prieto; jeffrey gershenwald; Marcella M Johnson; Marya F McCarty; Menashe Bar-Eli
Quantitative analysis of melanocytic tissue array reveals inverse correlation between activator protein-2alpha and protease-activated receptor-1 expression during melanoma progression.
The Journal of investigative dermatology 2007;127(2):387-93.
2005: Aaron J Berger; Darren W Davis; Carmen Tellez; Victor G Prieto; jeffrey gershenwald; Marcella M Johnson; David L Rimm; Menashe Bar-Eli
Automated quantitative analysis of activator protein-2alpha subcellular expression in melanoma tissue microarrays correlates with survival prediction.
Cancer research 2005;65(23):11185-92.
2005: Khalid A Mohamedali; Daniel Kedar; Paul Sweeney; Ashish Kamat; Darren W Davis; Beryl Y Eve; Samuel Huang; Philip E Thorpe; Colin P N Dinney; Michael G Rosenblum
The vascular-targeting fusion toxin VEGF121/rGel inhibits the growth of orthotopic human bladder carcinoma tumors.
Neoplasia (New York, N.Y.) 2005;7(10):912-20.
2005: Darren W Davis; Ryan Takamori; Chandrajit P Raut; Henry Q Xiong; Roy S Herbst; Walter M Stadler; John V Heymach; George D Demetri; Asif Rashid; Yu Shen; Sijin Wen; James L Abbruzzese; David J McConkey
Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 1):678-89.
2004: Chandrajit P Raut; Steffan Nawrocki; Laura M Lashinger; Darren W Davis; Sanaz Khanbolooki; Henry Xiong; Lee M Ellis; David J McConkey
Celecoxib inhibits angiogenesis by inducing endothelial cell apoptosis in human pancreatic tumor xenografts.
Cancer biology & therapy 2004;3(12):1217-24.
2004: John V Heymach; Jayesh Desai; Judith Manola; Darren W Davis; David J McConkey; David Harmon; David P Ryan; Glenwood Goss; Travis Quigley; Annick D Van den Abbeele; Stuart G Silverman; Susan Connors; Judah Folkman; Christopher D M Fletcher; George D Demetri
Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(17):5732-40.
2004: Darren W Davis; Keiji Inoue; Colin P N Dinney; Daniel J Hicklin; James L Abbruzzese; David J McConkey
Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts.
Cancer research 2004;64(13):4601-10.
2004: Chandrajit P Raut; Ryan Takamori; Darren W Davis; Bridget Sweeney-Gotsch; Michael S O'Reilly; David J McConkey
Direct effects of recombinant human endostatin on tumor cell IL-8 production are associated with increased endothelial cell apoptosis in an orthotopic model of human pancreatic cancer.
Cancer biology & therapy 2004;3(7):679-87.
2004: Ashish M Kamat; Takashi Karashima; Darren W Davis; Laura M Lashinger; Menashe Bar-Eli; Randall Millikan; Yu Shen; Colin P N Dinney; David J McConkey
The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo.
Molecular cancer therapeutics 2004;3(3):279-90.
2004: Darren W Davis; Yu Shen; Nizar A Mullani; Sijin Wen; Roy S Herbst; Michael O'Reilly; James L Abbruzzese; David J McConkey
Quantitative analysis of biomarkers defines an optimal biological dose for recombinant human endostatin in primary human tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):33-42.
2003: Darren W Davis; David J McConkey; Wei Zhang; Roy S Herbst
Antiangiogenic tumor therapy.
BioTechniques 2003;34(5):1048-50, 1052, 1054 passim.
2003: Darren W Davis; Thomas Buchholz; Kenneth R Hess; Aysegul A Sahin; Vicente Valero; David J McConkey
Automated quantification of apoptosis after neoadjuvant chemotherapy for breast cancer: early assessment predicts clinical response.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(3):955-60.
2003: Thomas Buchholz; Darren W Davis; David J McConkey; W Fraser Symmans; Vicente Valero; Anuja Jhingran; Susan L Tucker; Lajos Pusztai; Massimo Cristofanilli; Francisco J Esteva; Gabriel N Hortobagyi; Aysegul A Sahin
Chemotherapy-induced apoptosis and Bcl-2 levels correlate with breast cancer response to chemotherapy.
Cancer journal (Sudbury, Mass.) 2003;9(1):33-41.
2002: Roy S Herbst; Nizar A Mullani; Darren W Davis; Kenneth R Hess; David J McConkey; Chusilp Charnsangavej; Michael S O'Reilly; Hyung Woo Kim; Cheryl Baker; Jennifer Roach; Lee M Ellis; Asif Rashid; James Pluda; Corazon D Bucana; Timothy L Madden; Hai T Tran; James L Abbruzzese
Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(18):3804-14.
2002: Roy S Herbst; Kenneth R Hess; Hai T Tran; Jennifer E Tseng; Nizar A Mullani; Chusilp Charnsangavej; Timothy Madden; Darren W Davis; David J McConkey; Michael S O'Reilly; Lee M Ellis; James Pluda; Waun Ki Hong; James L Abbruzzese
Phase I study of recombinant human endostatin in patients with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(18):3792-803.
2001: S Ozawa; H Shinohara; Hiro-Omi Kanayama; Christiane J Bruns; Corazon D Bucana; Lee M Ellis; Darren W Davis; Isaiah J Fidler
Suppression of angiogenesis and therapy of human colon cancer liver metastasis by systemic administration of interferon-alpha.
Neoplasia (New York, N.Y.) 2001;3(2):154-64.
2001: RM Shaheen; WW Tseng; Darren W Davis; Wenbiao Liu; Niels Reinmuth; R Vellagas; A A Wieczorek; Y Ogura; David J McConkey; KE Drazan; Corazon D Bucana; G McMahon; Lee M Ellis
Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms.
Cancer research 2001;61(4):1464-8.
2000: Keji Inoue; Joel W Slaton; Paul Perrotte; Darren W Davis; Christiane J Bruns; Daniel J Hicklin; David J McConkey; Paul Sweeney; Robert Radinsky; Colin P N Dinney
Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(12):4874-84.
2000: S Yano; H Shinohara; Roy S Herbst; H Kuniyasu; Corazon D Bucana; Lee M Ellis; Darren W Davis; David J McConkey; Isaiah J Fidler
Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis.
Cancer research 2000;60(17):4959-67.
2000: Christiane J Bruns; Wenbiao Liu; Darren W Davis; RM Shaheen; David J McConkey; M R Wilson; Corazon D Bucana; Daniel J Hicklin; Lee M Ellis
Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases.
Cancer 2000;89(3):488-99.
2000: Keji Inoue; Joel W Slaton; Darren W Davis; Daniel J Hicklin; David J McConkey; Takashi Karashima; Robert Radinsky; Colin P N Dinney
Treatment of human metastatic transitional cell carcinoma of the bladder in a murine model with the anti-vascular endothelial growth factor receptor monoclonal antibody DC101 and paclitaxel.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(7):2635-43.
2000: Didier Jean; Carmen Tellez; Suyun Huang; Darren W Davis; Christiane J Bruns; David J McConkey; S H Hinrichs; Menashe Bar-Eli
Inhibition of tumor growth and metastasis of human melanoma by intracellular anti-ATF-1 single chain Fv fragment.
Oncogene 2000;19(22):2721-30.
2000: Christiane J Bruns; Matthew T Harbison; Darren W Davis; Charles Portera; Rachel Tsan; David J McConkey; Douglas B Evans; James L Abbruzzese; Daniel J Hicklin; Robert Radinsky
Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1936-48.
2000: Christiane J Bruns; H Shinohara; Matthew T Harbison; Darren W Davis; Gina M Nelkin; Jerald J Killion; David J McConkey; Zhongyun Dong; Isaiah J Fidler
Therapy of human pancreatic carcinoma implants by irinotecan and the oral immunomodulator JBT 3002 is associated with enhanced expression of inducible nitric oxide synthase in tumor-infiltrating macrophages.
Cancer research 2000;60(1):2-7.
1999: RM Shaheen; Darren W Davis; Wenbiao Liu; BK Zebrowski; M R Wilson; Corazon D Bucana; David J McConkey; G McMahon; Lee M Ellis
Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis.
Cancer research 1999;59(21):5412-6.

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