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John Davis

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Susan M Westaway; Mervyn Thompson; Harshad K Rami; Geoffrey Stemp; Leontine S Trouw; Darren J Mitchell; Jon T Seal; Stephen J Medhurst; Sarah C Lappin; James Biggs; James Wright; Sandra Arpino; Jeffrey C Jerman; Jennifer E Cryan; Vicky Holland; Kim Y Winborn; Tanya Coleman; Alexander J Stevens; John B Davis; Martin J Gunthorpe
Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1.
David R Howlett; K Bowler; Peter E Soden; David Riddell; John B Davis; Jill C Richardson; Stephen A Burbidge; M I Gonzalez; Elaine A Irving; A Lawman; G Miglio; E L Dawson; E R Howlett; Ishrut Hussain
Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease.
Martin Gunthorpe; Sara Luis Hannan; Darren Smart; Jeffrey C Jerman; Sandra Arpino; Graham D Smith; Stephen J Brough; Jim Wright; Julie Egerton; Sarah C Lappin; Vicky Holland; Kim Y Winborn; Mervyn Thompson; Harshad K Rami; Andrew Randall; John B Davis
Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.

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2008: Susan M Westaway; Mervyn Thompson; Harshad K Rami; Geoffrey Stemp; Leontine S Trouw; Darren J Mitchell; Jon T Seal; Stephen J Medhurst; Sarah C Lappin; James Biggs; James Wright; Sandra Arpino; Jeffrey C Jerman; Jennifer E Cryan; Vicky Holland; Kim Y Winborn; Tanya Coleman; Alexander J Stevens; John B Davis; Martin J Gunthorpe
Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1.
Bioorganic & medicinal chemistry letters 2008;18(20):5609-13.
2008: David R Howlett; K Bowler; Peter E Soden; David Riddell; John B Davis; Jill C Richardson; Stephen A Burbidge; M I Gonzalez; Elaine A Irving; A Lawman; G Miglio; E L Dawson; E R Howlett; Ishrut Hussain
Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease.
Histology and histopathology 2008;23(1):67-76.
2007: Martin Gunthorpe; Sara Luis Hannan; Darren Smart; Jeffrey C Jerman; Sandra Arpino; Graham D Smith; Stephen J Brough; Jim Wright; Julie Egerton; Sarah C Lappin; Vicky Holland; Kim Y Winborn; Mervyn Thompson; Harshad K Rami; Andrew Randall; John B Davis
Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.
The Journal of pharmacology and experimental therapeutics 2007;321(3):1183-92.
2007: Andrew D Medhurst; Michael A Briggs; Gordon Bruton; Andy Robert Calver; Iain P Chessell; Barry Crook; John B Davis; Robert P Davis; Andrew G Foley; Teresa Heslop; Warren D Hirst; Stephen J Medhurst; Sandrine Ociepka; Alison Ray; Ciaran M Regan; Becky Sargent; Joanne Schogger; Tania O Stean; Brenda K Trail; Neil Upton; Trevor White; Barry Orlek; David M Wilson
Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats.
Biochemical pharmacology 2007;73(8):1182-94.
2007: Ishrut Hussain; Julie Hawkins; David Harrison; Christopher Hille; Gareth Wayne; Leanne Cutler; Tania Buck; Daryl Walter; Emmanuel Demont; Colin Howes; Alan Naylor; Phillip Jeffrey; Maria I Gonzalez; Colin Dingwall; Anton Michel; Sally Redshaw; John B Davis
Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
Journal of neurochemistry 2007;100(3):802-9.
2006: Susan M Westaway; Ying-Kit Chung; John B Davis; Vicky Holland; Jeffrey C Jerman; Stephen J Medhurst; Harshad K Rami; Geoffrey Stemp; Alexander J Stevens; Mervyn Thompson; Kim Y Winborn; James Wright
N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1.
Bioorganic & medicinal chemistry letters 2006;16(17):4533-6.
2006: Stephen Skaper; Laura Facci; Ainsley A Culbert; Nicholas A Evans; Iain P Chessell; John B Davis; Jill C Richardson
P2X(7) receptors on microglial cells mediate injury to cortical neurons in vitro.
Glia 2006;54(3):234-42.
2006: Harshad K Rami; Mervyn Thompson; Geoffrey Stemp; Steve Fell; Jeffrey C Jerman; Alexander J Stevens; Darren Smart; Becky Sargent; Dominic Sanderson; Andrew D Randall; Martin Gunthorpe; John B Davis
Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.
Bioorganic & medicinal chemistry letters 2006;16(12):3287-91.
2004: Harshad K Rami; Mervyn Thompson; Paul A Wyman; Jeffrey C Jerman; Julie Egerton; Stephen J Brough; Alexander J Stevens; Andrew D Randall; Darren Smart; Martin Gunthorpe; John B Davis
Discovery of small molecule antagonists of TRPV1.
Bioorganic & medicinal chemistry letters 2004;14(14):3631-4.
2004: Jenny C Roberts; John B Davis; Christopher D Benham
[3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution.
Brain research 2004;995(2):176-83.
2004: Martin Gunthorpe; Harshad K Rami; Jeffrey C Jerman; Darren Smart; Catherine H Gill; Ellen M Soffin; S Luis Hannan; Sarah C Lappin; Julie Egerton; Graham D Smith; Angela Worby; L Howett; D Owen; S Nasir; Ceri H Davies; Mervyn Thompson; Paul A Wyman; Andrew D Randall; John B Davis
Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist.
Neuropharmacology 2004;46(1):133-49.
2003: Alison M Ray; Christopher D Benham; Jenny C Roberts; Catherine H Gill; Christophe Lanneau; Danniel P Gitterman; Mark H Harries; John B Davis; Ceri H Davies
Capsazepine protects against neuronal injury caused by oxygen glucose deprivation by inhibiting I(h).
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(31):10146-53.
2003: Christopher D Benham; Martin Gunthorpe; John B Davis
TRPV channels as temperature sensors.
Cell calcium 2003;33(5-6):479-87.
2003: Michela Rigoni; Marcello Trevisani; David Gazzieri; Riccardo Nadaletto; Michele Tognetto; Christophe Creminon; John B Davis; Barbara Campi; Silvia Amadesi; Pierangelo Geppetti; Selena Harrison
Neurogenic responses mediated by vanilloid receptor-1 (TRPV1) are blocked by the high affinity antagonist, iodo-resiniferatoxin.
British journal of pharmacology 2003;138(5):977-85.
2003: C L H Chan; Paul Facer; John B Davis; Graham D Smith; Julie Egerton; Chas Bountra; Norman S Williams; Praveen Anand
Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency.
Lancet 2003;361(9355):385-91.
2003: Ian C B Marshall; Davina E Owen; Tim V Cripps; John B Davis; Shaun McNulty; Darren Smart
Activation of vanilloid receptor 1 by resiniferatoxin mobilizes calcium from inositol 1,4,5-trisphosphate-sensitive stores.
British journal of pharmacology 2003;138(1):172-6.
2003: Vera Ralevic; Jeffrey C Jerman; Stephen J Brough; John B Davis; Julie Egerton; Darren Smart
Pharmacology of vanilloids at recombinant and endogenous rat vanilloid receptors.
Biochemical pharmacology 2003;65(1):143-51.
2002: Jeffrey C Jerman; J Gray; Stephen J Brough; L Ooi; D Owen; John B Davis; Darren Smart
Comparison of effects of anandamide at recombinant and endogenous rat vanilloid receptors.
British journal of anaesthesia 2002;89(6):882-7.
2002: Graham D Smith; Martin Gunthorpe; Rosemary E Kelsell; PD Hayes; P Reilly; Paul Facer; J E Wright; Jeffrey C Jerman; J-P Walhin; L Ooi; Julie Egerton; K J Charles; Darren Smart; Andrew D Randall; Praveen Anand; John B Davis
TRPV3 is a temperature-sensitive vanilloid receptor-like protein.
Nature 2002;418(6894):186-90.
2002: Christopher D Benham; John B Davis; Andrew D Randall
Vanilloid and TRP channels: a family of lipid-gated cation channels.
Neuropharmacology 2002;42(7):873-88.
2002: Marcello Trevisani; Darren Smart; Martin Gunthorpe; Michele Tognetto; M Barbieri; Barbara Campi; Silvia Amadesi; J Gray; Jeffrey C Jerman; Stephen J Brough; D Owen; G D Smith; Andrew D Randall; Selena Harrison; A Bianchi; John B Davis; Pierangelo Geppetti
Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1.
Nature neuroscience 2002;5(6):546-51.
2002: Hiroyuki Watanabe; John B Davis; Darren Smart; Jeffrey C Jerman; Graham D Smith; Phil Hayes; Joris Vriens; William Cairns; Ulrich Wissenbach; Jean Prenen; Veit Flockerzi; Guy Droogmans; Christopher D Benham; Bernd Nilius
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives.
The Journal of biological chemistry 2002;277(16):13569-77.
2002: Antonio Riccio; Cesar Mattei; Rosemary E Kelsell; Andrew D Medhurst; Andy Robert Calver; Andrew D Randall; John B Davis; Christopher D Benham; Menelas Pangalos
Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx.
The Journal of biological chemistry 2002;277(14):12302-9.
2002: Martin Gunthorpe; Christopher D Benham; Andrew Randall; John B Davis
The diversity in the vanilloid (TRPV) receptor family of ion channels.
Trends in pharmacological sciences 2002;23(4):183-91.
2001: Luciano De Petrocellis; John B Davis; Vincenzo Di Marzo
Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors.
FEBS letters 2001;506(3):253-6.
2001: Tiziana Bisogno; Lumír O Hanus; Luciano De Petrocellis; Susanna Tchilibon; Datta E Ponde; Ines Brandi; Aniello Schiano Moriello; John B Davis; Urij Rampampam; Vincenzo Di Marzo
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.
British journal of pharmacology 2001;134(4):845-52.
2001: Martin Gunthorpe; G D Smith; John B Davis; Andrew D Randall
Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cells.
Pflügers Archiv : European journal of physiology 2001;442(5):668-74.
2001: Luciano De Petrocellis; Selena Harrison; Tiziana Bisogno; Michele Tognetto; Ines Brandi; G D Smith; Christophe Creminon; John B Davis; Pierangelo Geppetti; Vincenzo Di Marzo
The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase.
Journal of neurochemistry 2001;77(6):1660-3.
2001: Vincenzo Di Marzo; Isabel Lastres-Becker; Tiziana Bisogno; Luciano De Petrocellis; A Milone; John B Davis; Javier Fernandez-Ruiz
Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues.
European journal of pharmacology 2001;420(2-3):123-31.
2001: Luciano De Petrocellis; Tiziana Bisogno; Mauro Maccarrone; John B Davis; A Finazzi-Agro; Vincenzo Di Marzo
The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism.
The Journal of biological chemistry 2001;276(16):12856-63.
2001: Vera Ralevic; David A Kendall; Jeffrey C Jerman; John B Davis; Derek N Middlemiss; Darren Smart
Low pH modulation of recombinant vanilloid receptors and perivascular capsaicin-sensitive sensory neurotransmission.
Autonomic neuroscience : basic & clinical 2001;88(1-2):36-44.
2001: Darren Smart; Jeffrey C Jerman; Martin Gunthorpe; Stephen J Brough; J Ranson; William Cairns; PD Hayes; Andrew D Randall; John B Davis
Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology.
European journal of pharmacology 2001;417(1-2):51-8.
2001: Vincenzo Di Marzo; Tiziana Bisogno; Luciano De Petrocellis; Ines Brandi; Reneé G Jefferson; Ramona Winckler; John B Davis; O Dasse; Anu Mahadevan; Raj K Razdan; Billy R Martin
Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor "hybrid" ligands.
Biochemical and biophysical research communications 2001;281(2):444-51.
2000: P Hayes; Helen J Meadows; Martin Gunthorpe; Mark H Harries; DM Duckworth; William Cairns; David C Harrison; Catherine E Clarke; K Ellington; Rab Prinjha; A J Barton; Andrew D Medhurst; G D Smith; S Topp; Paul R Murdock; GJ Sanger; JA Terrett; O Jenkins; Christopher D Benham; Andrew D Randall; IS Gloger; John B Davis
Cloning and functional expression of a human orthologue of rat vanilloid receptor-1.
Pain 2000;88(2):205-15.
2000: Luciano De Petrocellis; Tiziana Bisogno; John B Davis; R G Pertwee; Vincenzo Di Marzo
Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity.
FEBS letters 2000;483(1):52-6.
2000: Carol W Gray; RV Ward; EH Karran; S Turconi; A Rowles; D Viglienghi; Christopher Southan; A Barton; Kenneth G M Fantom; A West; John Savopoulos; N J Hassan; H Clinkenbeard; C Hanning; B Amegadzie; John B Davis; Colin Dingwall; George P Livi; Caretha L Creasy
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.
European journal of biochemistry / FEBS 2000;267(18):5699-710.
2000: Martin Gunthorpe; Mark H Harries; Rab Prinjha; John B Davis; Andrew Randall
Voltage- and time-dependent properties of the recombinant rat vanilloid receptor (rVR1).
The Journal of physiology 2000;525 Pt 3():747-59.
2000: Alison M Ray; Davina E Owen; ML Evans; John B Davis; Christopher D Benham
Caspase inhibitors are functionally neuroprotective against oxygen glucose deprivation induced CA1 death in rat organotypic hippocampal slices.
Brain research 2000;867(1-2):62-9.
2000: Jeffrey C Jerman; Stephen J Brough; Rab Prinjha; Mark H Harries; John B Davis; Darren Smart
Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology.
British journal of pharmacology 2000;130(4):916-22.
2000: RV Ward; K H Jennings; R Jepras; W Neville; Davina E Owen; J Hawkins; Graham R Christie; John B Davis; A George; EH Karran; David R Howlett
Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of beta-amyloid peptide.
The Biochemical journal 2000;348 Pt 1():137-44.
2000: John B Davis; J Gray; Martin Gunthorpe; Jonathan P Hatcher; Philip T Davey; Philip Overend; Mark H Harries; JK Latcham; C Clapham; K Atkinson; S A Hughes; K Rance; Evelyn Grau; Alex J Harper; Perdita L Pugh; Derek C Rogers; Sharon Bingham; Andrew Randall; S A Sheardown
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia.
Nature 2000;405(6783):183-7.
2000: Darren Smart; Martin Gunthorpe; Jeffrey C Jerman; S Nasir; J Gray; Alison I Muir; Jon K Chambers; Andrew D Randall; John B Davis
The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1).
British journal of pharmacology 2000;129(2):227-30.
1999: Dirk Beher; C Elle; J Underwood; John B Davis; R Ward; EH Karran; Colin L Masters; Konrad Beyreuther; Gerd Multhaup
Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain.
Journal of neurochemistry 1999;72(4):1564-73.