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Mark Davis

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Laura F Su; Arnold Han; Brian A Kidd; Jonathan J Kotzin; Mark M Davis
Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults.
Ning Jiang; Lolita Penland; Mark M Davis; Cornelia L Dekker; Daniel S Fisher; Harry B Greenberg; Jiankui He; Xiao-Song He; Min Huang; Sanae Sasaki; Meghan Sullivan; Joshua A Weinstein; Patrick C Wilson; Nai-Ying Zheng; Stephen R Quake
Lineage structure of the human antibody repertoire in response to influenza vaccination.
David Furman; Huang Huang; Justin Jarrell; Vladimir Jojic; Brian Kidd; Daphne Koller; Peder Lund; Holden T Maecker; Jordan Price; Shai Shen-Orr; Tiffany Tse; Paul J Utz; Cornelia L Dekker; Mark M Davis
Apoptosis and other immune biomarkers predict influenza vaccine responsiveness.

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All Publications

2013: Laura F Su; Arnold Han; Brian A Kidd; Jonathan J Kotzin; Mark M Davis
Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults.
Immunity 2013;38(2):373-83.
2013: Ning Jiang; Lolita Penland; Mark M Davis; Cornelia L Dekker; Daniel S Fisher; Harry B Greenberg; Jiankui He; Xiao-Song He; Min Huang; Sanae Sasaki; Meghan Sullivan; Joshua A Weinstein; Patrick C Wilson; Nai-Ying Zheng; Stephen R Quake
Lineage structure of the human antibody repertoire in response to influenza vaccination.
Science translational medicine 2013;5(171):171ra19.
2013: David Furman; Huang Huang; Justin Jarrell; Vladimir Jojic; Brian Kidd; Daphne Koller; Peder Lund; Holden T Maecker; Jordan Price; Shai Shen-Orr; Tiffany Tse; Paul J Utz; Cornelia L Dekker; Mark M Davis
Apoptosis and other immune biomarkers predict influenza vaccine responsiveness.
Molecular systems biology 2013;9():659.
2013: Jianming Xie; Cristina M Tato; Mark M Davis
How the immune system talks to itself: the varied role of synapses.
Immunological reviews 2013;251(1):65-79.
2012: Jeremy I Pearl; Mark M Davis; Leslie S Kean; Joseph C Wu
Pluripotent stem cells: immune to the immune system?
Science translational medicine 2012;4(164):164ps25.
2012: Xun Zeng; Mark M Davis; Jun Huang; Brian A Kidd; Michael S Kuhns; Evan W Newell; Ray W Waters; Casey T Weaver; Yu-Ling Wei; Hongxiang Yu; Yueh-hsiu Chien
γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.
Immunity 2012;37(3):524-34.
2012: Jianming Xie; Peter J R Ebert; Jun Huang; Johannes B Huppa; Qi-Jing Li; Evan W Newell; Mark M Davis
Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC.
Nature immunology 2012;13(7):674-80.
2012: K Scott Weber; Jeff D Campbell; Mark M Davis; Qi-Jing Li; Stephen P Persaud; Paul M Allen
Distinct CD4+ helper T cells involved in primary and secondary responses to infection.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(24):9511-6.
2012: Chunlin Wang; Julie Wilhelmy; Lilit Stepanyan; Laura F Su; Farbod Babrzadeh; Mark M Davis; Ronald W Davis; Marcelo A Fernandez-Viña; Sujatha Krishnakumar; Douglas Levinson; Michael Mindrinos
High-throughput, high-fidelity HLA genotyping with deep sequencing.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(22):8676-81.
2012: Joong-Ho Won; Shai S Shen-Orr; Mark M Davis; Ofir Goldberger; Richard A Olshen
Significance analysis of xMap cytokine bead arrays.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(8):2848-53.
2012: Evan W Newell; Garry P Nolan; Natalia Sigal; Sean C Bendall; Mark M Davis
Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes.
Immunity 2012;36(1):142-52.
2012: Mark M Davis
Immunology taught by humans.
Science translational medicine 2012;4(117):117fs2.
2011: Hironori Ueda; J Richard McIntosh; Mary K Morphew; Mark M Davis
CD4+ T-cell synapses involve multiple distinct stages.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(41):17099-104.
2011: Mark M Davis; John D Altman; Evan W Newell
Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis.
Nature reviews. Immunology 2011;11(8):551-8.
2011: Evan W Newell; Lauren K Ely; Andrew C Kruse; Philip A Reay; Stephanie N Rodriguez; Aaron E Lin; Michael S Kuhns; K Christopher Garcia; Mark M Davis
Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).
Journal of immunology (Baltimore, Md. : 1950) 2011;186(10):5823-32.
2011: Jeremy I Pearl; Andrew S Lee; Dennis B Leveson-Gower; Ning Sun; Zhumur Ghosh; Feng Lan; Julia Ransohoff; Robert S Negrin; Mark M Davis; Joseph C Wu
Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells.
Cell stem cell 2011;8(3):309-17.
2011: Xiaosong He; Sanae Sasaki; Carlos F Narvaez; Caiqiu Zhang; Hui Liu; Jennifer C Woo; George W Kemble; Cornelia L Dekker; Mark M Davis; Harry B Greenberg
Plasmablast-derived polyclonal antibody response after influenza vaccination.
Journal of immunological methods 2011;365(1-2):67-75.
2011: Keishi Adachi; Mark M Davis
T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(4):1549-54.
2011: Björn F Lillemeier; Mark M Davis
Probing the plasma membrane structure of immune cells through the analysis of membrane sheets by electron microscopy.
Methods in molecular biology (Clifton, N.J.) 2011;748():169-82.
2010: Jeremy Juang; Peter J R Ebert; Dan Feng; K Christopher Garcia; Michelle Krogsgaard; Mark M Davis
Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection.
The Journal of experimental medicine 2010;207(6):1223-34.
2010: Michael S Kuhns; Andrew T Girvin; Lawrence O Klein; Rebecca Chen; Kirk D C Jensen; Evan W Newell; Johannes B Huppa; Björn F Lillemeier; Morgan Huse; Yueh-hsiu Chien; K Christopher Garcia; Mark M Davis
Evidence for a functional sidedness to the alphabetaTCR.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):5094-9.
2010: Johannes B Huppa; Markus Axmann; Manuel A Mörtelmaier; Björn F Lillemeier; Evan W Newell; Mario Brameshuber; Lawrence O Klein; Gerhard J Schütz; Mark M Davis
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.
Nature 2010;463(7283):963-7.
2010: Peter J R Ebert; Qi-Jing Li; Johannes B Huppa; Mark M Davis
Functional development of the T cell receptor for antigen.
Progress in molecular biology and translational science 2010;92():65-100.
2010: Björn F Lillemeier; Manuel A Mörtelmaier; Martin B Forstner; Johannes B Huppa; Jay T Groves; Mark M Davis
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.
Nature immunology 2010;11(1):90-6.
2009: Peter J R Ebert; Shan Jiang; Jianming Xie; Qi-Jing Li; Mark M Davis
An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a.
Nature immunology 2009;10(11):1162-9.
2009: Evan W. Newell; Lawrence O Klein; Wong Yu; Mark M Davis
Simultaneous detection of many T-cell specificities using combinatorial tetramer staining.
Nature methods 2009;6(7):497-9.
2009: AmirAli H Talasaz; Ashley A Powell; David E Huber; James G Berbee; Kyung-Ho Roh; Wong Yu; wenzhong xiao; Mark M Davis; R Fabian Pease; Michael N Mindrinos; Stefanie S Jeffrey; Ronald W Davis
Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):3970-5.
2009: Shai S Shen-Orr; Ofir Goldberger; Yael Garten; Yael Rosenberg-Hasson; Patricia A Lovelace; DL Hirschberg; Russ B Altman; Mark M Davis; Atul Butte
Towards a cytokine-cell interaction knowledgebase of the adaptive immune system.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2009;():439-50.
2008: Michael S Kuhns; Mark M Davis
The safety on the TCR trigger.
Cell 2008;135(4):594-6.
2008: Peter J R Ebert; Lauren I Richie Ehrlich; Mark M Davis
Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation.
Immunity 2008;29(5):734-45.
2008: Rutger-Jan Swijnenburg; Sonja Schrepfer; Johannes A Govaert; Feng Cao; Katie Ransohoff; Ahmad Y Sheikh; Munif Haddad; Andrew J Connolly; Mark M Davis; Robert C Robbins; Joseph C Wu
Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12991-6.
2008: Kirk D C Jensen; Xiaoqin Su; Sunny Shin; Luke Li; Sawsan Youssef; Sho Yamasaki; Lawrence Steinman; Takashi Saito; Richard M Locksley; Mark M Davis; Nicole Baumgarth; Yueh-hsiu Chien
Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma.
Immunity 2008;29(1):90-100.
2007: Mark M Davis
The alphabeta T cell repertoire comes into focus.
Immunity 2007;27(2):179-80.
2007: Michelle Krogsgaard; Jeremy Juang; Mark M Davis
A role for "self" in T-cell activation.
Seminars in immunology 2007;19(4):236-44.
2007: Morgan Huse; Lawrence O Klein; Andrew T Girvin; Joycelyn M Faraj; Qi-Jing Li; Michael S Kuhns; Mark M Davis
Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist.
Immunity 2007;27(1):76-88.
2007: Mark M Davis
Blimp-1 over Budapest.
Nature immunology 2007;8(5):445-7.
2007: Alexander J Bankovich; Stefan Raunser; Z Sean Juo; Thomas Walz; Mark M Davis; K Christopher Garcia
Structural insight into pre-B cell receptor function.
Science (New York, N.Y.) 2007;316(5822):291-4.
2007: Qi-Jing Li; Jacqueline Chau; Peter J R Ebert; Giselle Sylvester; Hyeyoung Min; Gwen Liu; Ravi Braich; Muthiah Manoharan; juergen soutschek; Petra Skare; Lawrence O Klein; Mark M Davis; Chang-Zheng Chen
miR-181a is an intrinsic modulator of T cell sensitivity and selection.
Cell 2007;129(1):147-61.
2007: Michael S Kuhns; Mark M Davis
Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling.
Immunity 2007;26(3):357-69.
2007: Mark M Davis; Michelle Krogsgaard; Morgan Huse; Johannes B Huppa; Björn F Lillemeier; Qi-Jing Li
T cells as a self-referential, sensory organ.
Annual review of immunology 2007;25():681-95.
2006: Björn F Lillemeier; Janet R Pfeiffer; Zurab Surviladze; Bridget S Wilson; Mark M Davis
Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):18992-7.
2006: Kentner Singleton; Nadia Parvaze; Kavyya R Dama; Kenneth S Chen; Paula Jennings; Bozidar Purtic; michael sjaastad; Christopher Gilpin; Mark M Davis; Christoph Wülfing
A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4402-13.
2006: Shuyan Qi; Michelle Krogsgaard; Mark M Davis; Arup K Chakraborty
Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4416-21.
2006: Morgan Huse; Björn F Lillemeier; Michael S Kuhns; Daniel S Chen; Mark M Davis
T cells use two directionally distinct pathways for cytokine secretion.
Nature immunology 2006;7(3):247-55.
2006: Michael S Kuhns; Mark M Davis; K Christopher Garcia
Deconstructing the form and function of the TCR/CD3 complex.
Immunity 2006;24(2):133-9.
2006: Daniel S Chen; Mark M Davis
Molecular and functional analysis using live cell microarrays.
Current opinion in chemical biology 2006;10(1):28-34.
2005: Daniel S Chen; Yoav Soen; Tor Stuge; Peter P Lee; Jeffrey S Weber; Patrick O Brown; Mark M Davis
Marked differences in human melanoma antigen-specific T cell responsiveness after vaccination using a functional microarray.
PLoS medicine 2005;2(10):e265.
2005: Peter M Kasson; Johannes B Huppa; Mark M Davis; Axel T Brunger
A hybrid machine-learning approach for segmentation of protein localization data.
Bioinformatics (Oxford, England) 2005;21(19):3778-86.
2005: Daniel S Chen; Mark M Davis
Cellular immunotherapy: antigen recognition is just the beginning.
Springer seminars in immunopathology 2005;27(1):119-27.
2005: Michelle Krogsgaard; Qi-Jing Li; Cenk Sumen; Johannes B Huppa; Morgan Huse; Mark M Davis
Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity.
Nature 2005;434(7030):238-43.
2005: Stéphane VINCENT; N Ray Dunn; Roger Sciammas; Miriam Shapiro-Shalef; Mark M Davis; Kathryn Calame; Elizabeth K Bikoff; Elizabeth J Robertson
The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse.
Development (Cambridge, England) 2005;132(6):1315-25.
2005: Michelle Krogsgaard; Mark M Davis
How T cells 'see' antigen.
Nature immunology 2005;6(3):239-45.
2005: Peter M Kasson; Mark M Davis; Axel T Brunger
Deformable modeling for improved calculation of molecular velocities from single-particle tracking.
Proceedings / IEEE Computational Systems Bioinformatics Conference, CSB. IEEE Computational Systems Bioinformatics Conference 2005;():208-11.
2005: Peter M Kasson; Johannes B Huppa; Michelle Krogsgaard; Mark M Davis; Axel T Brunger
Quantitative imaging of lymphocyte membrane protein reorganization and signaling.
Biophysical journal 2005;88(1):579-89.
2004: Cenk Sumen; Michael L Dustin; Mark M Davis
T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation.
The Journal of cell biology 2004;166(4):579-90.
2004: Mark M Davis
The evolutionary and structural 'logic' of antigen receptor diversity.
Seminars in immunology 2004;16(4):239-43.
2004: Qi-Jing Li; Aaron R Dinner; Shuyan Qi; Darrell J Irvine; Johannes B Huppa; Mark M Davis; Arup K Chakraborty
CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse.
Nature immunology 2004;5(8):791-9.
2004: Roger Sciammas; Mark M Davis
Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5427-40.
2004: Marco A Purbhoo; Darrell J Irvine; Johannes B Huppa; Mark M Davis
T cell killing does not require the formation of a stable mature immunological synapse.
Nature immunology 2004;5(5):524-30.
2003: Michelle Krogsgaard; Johannes B Huppa; Marco A Purbhoo; Mark M Davis
Linking molecular and cellular events in T-cell activation and synapse formation.
Seminars in immunology 2003;15(6):307-15.
2003: Yoav Soen; Daniel S Chen; Daniel L Kraft; Mark M Davis; Patrick O Brown
Detection and characterization of cellular immune responses using peptide-MHC microarrays.
PLoS biology 2003;1(3):E65.
2003: Michelle Krogsgaard; Nelida Prado; Erin J Adams; Xiao-lin He; Dar-Chone Chow; Darcy B Wilson; K Christopher Garcia; Mark M Davis
Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.
Molecular cell 2003;12(6):1367-78.
2003: Johannes B Huppa; Mark M Davis
T-cell-antigen recognition and the immunological synapse.
Nature reviews. Immunology 2003;3(12):973-83.
2003: Johannes B Huppa; Michael Gleimer; Cenk Sumen; Mark M Davis
Continuous T cell receptor signaling required for synapse maintenance and full effector potential.
Nature immunology 2003;4(8):749-55.
2003: Michelle R Kuhné; Joseph Lin; Deborah Yablonski; Marianne N Mollenauer; Lauren I Richie Ehrlich; Johannes B Huppa; Mark M Davis; Arthur Weiss
Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):860-6.
2003: Nadja Anikeeva; Tatiana Lebedeva; Michelle Krogsgaard; Sergey Y Tetin; Erik Martinez-Hackert; Spyros A Kalams; Mark M Davis; Yuri Sykulev
Distinct molecular mechanisms account for the specificity of two different T-cell receptors.
Biochemistry 2003;42(16):4709-16.
2003: Mark M Davis; Michelle Krogsgaard; Johannes B Huppa; Cenk Sumen; Marco A Purbhoo; Darrell J Irvine; Lawren C Wu; Lauren Ehrlich
Dynamics of cell surface molecules during T cell recognition.
Annual review of biochemistry 2003;72():717-42.
2002: Lauren I Richie Ehrlich; Peter J R Ebert; Matthew F Krummel; Arthur Weiss; Mark M Davis
Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation.
Immunity 2002;17(6):809-22.
2002: Ines Gütgemann; Jama M Darling; Harry B Greenberg; Mark M Davis; Yueh-hsiu Chien
A blood-borne antigen induces rapid T-B cell contact: a potential mechanism for tolerance induction.
Immunology 2002;107(4):420-5.
2002: William C Moss; Darrell J Irvine; Mark M Davis; Matthew F Krummel
Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):15024-9.
2002: Darrell J Irvine; Marco A Purbhoo; Michelle Krogsgaard; Mark M Davis
Direct observation of ligand recognition by T cells.
Nature 2002;419(6909):845-9.
2002: Daniel A Falco; Ronald R Nepomuceno; Sheri M Krams; Peter P Lee; Mark M Davis; Oscar Salvatierra; Steven R Alexander; Carlos O Esquivel; Kenneth L Cox; Lorry R Frankel; Olivia M Martinez
Identification of Epstein-Barr virus-specific CD8+ T lymphocytes in the circulation of pediatric transplant recipients.
Transplantation 2002;74(4):501-10.
2002: Mark M Davis
A new trigger for T cells.
Cell 2002;110(3):285-7.
2002: Lawren C Wu; Delphine S Tuot; Daniel S Lyons; K Christopher Garcia; Mark M Davis
Two-step binding mechanism for T-cell receptor recognition of peptide MHC.
Nature 2002;418(6897):552-6.
2002: Felix J Baker; Mark Lee; Yueh-hsiu Chien; Mark M Davis
Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9374-9.
2002: Lauren I Richie; Peter J R Ebert; Lawren C Wu; Matthew F Krummel; John J T Owen; Mark M Davis
Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection.
Immunity 2002;16(4):595-606.
2002: Christoph Wülfing; Cenk Sumen; michael sjaastad; Lawren C Wu; Michael L Dustin; Mark M Davis
Costimulation and endogenous MHC ligands contribute to T cell recognition.
Nature immunology 2002;3(1):42-7.
2001: AM Fahrer; Yves Konigshofer; E M Kerr; Ghassan Ghandour; DH Mack; Mark M Davis; Yueh-hsiu Chien
Attributes of gammadelta intraepithelial lymphocytes as suggested by their transcriptional profile.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10261-6.
2001: Lawrence Fong; Y Hou; A Rivas; Claudia Benike; A Yuen; George A Fisher; Mark M Davis; Edgar G Engleman
Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8809-14.
2001: PA Savage; Mark M Davis
A kinetic window constricts the T cell receptor repertoire in the thymus.
Immunity 2001;14(3):243-52.
2001: Xiaosong He; B Rehermann; Judie Boisvert; J Mumm; Holden T Maecker; Mario Roederer; Teresa L Wright; Vernon C Maino; Mark M Davis; Harry B Greenberg
Direct functional analysis of epitope-specific CD8+ T cells in peripheral blood.
Viral immunology 2001;14(1):59-69.
2001: Shannon K Bromley; W Richard Burack; Kenneth G Johnson; Kristina Somersalo; Tasha Sims; Cenk Sumen; Mark M Davis; Andrey S Shaw; Paul M Allen; Michael L Dustin
The immunological synapse.
Annual review of immunology 2001;19():375-96.
2000: Cassian Yee; J A Thompson; P Roche; D R Byrd; Peter P Lee; Michael Piepkorn; K Kenyon; Mark M Davis; Stanley R Riddell; Philip D Greenberg
Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of t cell-mediated vitiligo.
The Journal of experimental medicine 2000;192(11):1637-44.
2000: Matthew F Krummel; Christoph Wülfing; Cenk Sumen; Mark M Davis
Thirty-six views of T-cell recognition.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1400):1071-6.
2000: Christoph Wülfing; Angela Bauch; Gerald R Crabtree; Mark M Davis
The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10150-5.
2000: Matthew F Krummel; michael sjaastad; Christoph Wülfing; Mark M Davis
Differential clustering of CD4 and CD3zeta during T cell recognition.
Science (New York, N.Y.) 2000;289(5483):1349-52.
2000: J L Xu; Mark M Davis
Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities.
Immunity 2000;13(1):37-45.
2000: P A Reay; K Matsui; K Haase; C Wulfing; Yueh-hsiu Chien; Mark M Davis
Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5626-34.
2000: Peter M Kasson; Joshua D Rabinowitz; L Schmitt; Mark M Davis; Harden M McConnell
Kinetics of peptide binding to the class II MHC protein I-Ek.
Biochemistry 2000;39(5):1048-58.
1999: JJ Boniface; Z Reich; Daniel S Lyons; Mark M Davis
Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11446-51.
1999: K K Baldwin; B P Trenchak; John D Altman; Mark M Davis
Negative selection of T cells occurs throughout thymic development.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(2):689-98.
1999: Arash Grakoui; Shannon K Bromley; Cenk Sumen; Mark M Davis; Andrey S Shaw; Paul M Allen; Michael L Dustin
The immunological synapse: a molecular machine controlling T cell activation.
Science (New York, N.Y.) 1999;285(5425):221-7.
1999: L Schmitt; J R Kratz; Mark M Davis; Harden M McConnell
Catalysis of peptide dissociation from class II MHC-peptide complexes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6581-6.
1999: Peter P Lee; Cassian Yee; PA Savage; Lawrence Fong; DG Brockstedt; Jeffrey S Weber; D Johnson; S Swetter; J Thompson; Philip D Greenberg; Mario Roederer; Mark M Davis
Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients.
Nature medicine 1999;5(6):677-85.
1999: Xiaosong He; B Rehermann; F Xavier López-Labrador; Judie Boisvert; Ramsey Cheung; J Mumm; H Wedemeyer; Marina Berenguer; Teresa L Wright; Mark M Davis; Harry B Greenberg
Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5692-7.
1999: Christoph Wülfing; Yueh-hsiu Chien; Mark M Davis
Visualizing lymphocyte recognition.
Immunology and cell biology 1999;77(2):186-7.
1999: PA Savage; JJ Boniface; Mark M Davis
A kinetic basis for T cell receptor repertoire selection during an immune response.
Immunity 1999;10(4):485-92.
1999: Cassian Yee; PA Savage; Peter P Lee; Mark M Davis; Philip D Greenberg
Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2227-34.
1999: L Schmitt; JJ Boniface; Mark M Davis; Harden M McConnell
Conformational isomers of a class II MHC-peptide complex in solution.
Journal of molecular biology 1999;286(1):207-18.
1999: K K Baldwin; P A Reay; Lijun Wu; A Farr; Mark M Davis
A T cell receptor-specific blockade of positive selection.
The Journal of experimental medicine 1999;189(1):13-24.
1999: Mark M Davis; Christoph Wülfing; Matthew F Krummel; PA Savage; J Xu; Cenk Sumen; Michael L Dustin; Yueh-hsiu Chien
Visualizing T-cell recognition.
Cold Spring Harbor symposia on quantitative biology 1999;64():243-51.
1998: Christoph Wülfing; Mark M Davis
A receptor/cytoskeletal movement triggered by costimulation during T cell activation.
Science (New York, N.Y.) 1998;282(5397):2266-9.
1998: L Schmitt; JJ Boniface; Mark M Davis; Harden M McConnell
Kinetic isomers of a class II MHC-peptide complex.
Biochemistry 1998;37(50):17371-80.
1998: Joshua D Rabinowitz; Marija Vrljic; Peter M Kasson; M N Liang; Robert Busch; JJ Boniface; Mark M Davis; Harden M McConnell
Formation of a highly peptide-receptive state of class II MHC.
Immunity 1998;9(5):699-709.
1998: JJ Boniface; Joshua D Rabinowitz; Christoph Wülfing; J Hampl; Z Reich; John D Altman; Rami Kantor; Craig Beeson; Harden M McConnell; Mark M Davis
Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected].
Immunity 1998;9(4):459-66.
1998: E J Messika; P S Lu; Y J Sung; T Yao; Jen-Tsan Chi; Yueh-hsiu Chien; Mark M Davis
Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development.
The Journal of experimental medicine 1998;188(3):515-25.
1998: Ines Gütgemann; AM Fahrer; John D Altman; Mark M Davis; Yueh-hsiu Chien
Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen.
Immunity 1998;8(6):667-73.
1998: Christoph Wülfing; michael sjaastad; Mark M Davis
Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6302-7.
1998: Mark M Davis; JJ Boniface; Z Reich; D Lyons; J Hampl; B Arden; Y Chien
Ligand recognition by alpha beta T cell receptors.
Annual review of immunology 1998;16():523-44.
1997: J Hampl; Yueh-hsiu Chien; Mark M Davis
CD4 augments the response of a T cell to agonist but not to antagonist ligands.
Immunity 1997;7(3):379-85.
1997: Srinivas Akkaraju; W Y Ho; D Leong; K Canaan; Mark M Davis; Christopher C Goodnow
A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.
Immunity 1997;7(2):255-71.
1997: Z Reich; JJ Boniface; Daniel S Lyons; N Borochov; Ellen Wachtel; Mark M Davis
Ligand-specific oligomerization of T-cell receptor molecules.
Nature 1997;387(6633):617-20.
1997: Christoph Wülfing; Joshua D Rabinowitz; Craig Beeson; michael sjaastad; Harden M McConnell; Mark M Davis
Kinetics and extent of T cell activation as measured with the calcium signal.
The Journal of experimental medicine 1997;185(10):1815-25.
1997: Z Reich; John D Altman; JJ Boniface; Daniel S Lyons; H Kozono; G Ogg; C Morgan; Mark M Davis
Stability of empty and peptide-loaded class II major histocompatibility complex molecules at neutral and endosomal pH: comparison to class I proteins.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2495-500.
1997: Mark M Davis; Daniel S Lyons; John D Altman; M McHeyzer-Williams; J Hampl; JJ Boniface; Y Chien
T cell receptor biochemistry, repertoire selection and general features of TCR and Ig structure.
Ciba Foundation symposium 1997;204():94-100; discussion 100-4.
1996: John D Altman; P A Moss; P J Goulder; D H Barouch; Michael G McHeyzer-Williams; J I Bell; A J McMichael; Mark M Davis
Phenotypic analysis of antigen-specific T lymphocytes.
Science (New York, N.Y.) 1996;274(5284):94-6.
1996: Joshua D Rabinowitz; Craig Beeson; Christoph Wülfing; K Tate; P M Allen; Mark M Davis; Harden M McConnell
Altered T cell receptor ligands trigger a subset of early T cell signals.
Immunity 1996;5(2):125-35.
1996: Craig Beeson; J Rabinowitz; K Tate; I Gütgemann; Yueh-hsiu Chien; Patricia P Jones; Mark M Davis; Harden M McConnell
Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface.
The Journal of experimental medicine 1996;184(2):777-82.
1996: Daniel S Lyons; S A Lieberman; J Hampl; JJ Boniface; Y Chien; Leslie J Berg; Mark M Davis
A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists.
Immunity 1996;5(1):53-61.
1996: Michael G McHeyzer-Williams; John D Altman; Mark M Davis
Enumeration and characterization of memory cells in the TH compartment.
Immunological reviews 1996;150():5-21.
1996: Michael G McHeyzer-Williams; John D Altman; Mark M Davis
Tracking antigen-specific helper T cell responses.
Current opinion in immunology 1996;8(2):278-84.
1996: Mark M Davis
Evolving catalysts in real time.
Science (New York, N.Y.) 1996;271(5252):1078-9.
1996: Joshua D Rabinowitz; Craig Beeson; Daniel S Lyons; Mark M Davis; Harden M McConnell
Kinetic discrimination in T-cell activation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1401-5.
1996: JJ Boniface; Daniel S Lyons; D A Wettstein; N L Allbritton; Mark M Davis
Evidence for a conformational change in a class II major histocompatibility complex molecule occurring in the same pH range where antigen binding is enhanced.
The Journal of experimental medicine 1996;183(1):119-26.
1995: JJ Boniface; Mark M Davis
T-cell recognition of antigen. A process controlled by transient intermolecular interactions.
Annals of the New York Academy of Sciences 1995;766():62-9.
1995: Jeffrey C Rathmell; M P Cooke; W Y Ho; J Grein; S E Townsend; Mark M Davis; Christopher C Goodnow
CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells.
Nature 1995;376(6536):181-4.
1995: Mark M Davis; Michael G McHeyzer-Williams; Yueh-hsiu Chien
T-cell receptor V-region usage and antigen specificity. The cytochrome c model system.
Annals of the New York Academy of Sciences 1995;756():1-11.
1995: Mark M Davis; Y Chien
Issues concerning the nature of antigen recognition by alpha beta and gamma delta T-cell receptors.
Immunology today 1995;16(7):316-8.
1995: Michael G McHeyzer-Williams; Mark M Davis
Antigen-specific development of primary and memory T cells in vivo.
Science (New York, N.Y.) 1995;268(5207):106-11.
1994: K Matsui; JJ Boniface; Peter Steffner; P A Reay; Mark M Davis
Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12862-6.
1994: W Y Ho; M P Cooke; Christopher C Goodnow; Mark M Davis
Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.
The Journal of experimental medicine 1994;179(5):1539-49.
1994: C A Turner; D H Mack; Mark M Davis
Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells.
Cell 1994;77(2):297-306.
1994: P A Reay; R M Kantor; Mark M Davis
Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103).
Journal of immunology (Baltimore, Md. : 1950) 1994;152(8):3946-57.
1994: S Sakaguchi; T H Ermak; M Toda; Leslie J Berg; W Ho; B Fazekas de St Groth; P A Peterson; N Sakaguchi; Mark M Davis
Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):1471-84.
1994: H Schild; N Mavaddat; C Litzenberger; E W Ehrich; Mark M Davis; J A Bluestone; L Matis; R K Draper; Yueh-hsiu Chien
The nature of major histocompatibility complex recognition by gamma delta T cells.
Cell 1994;76(1):29-37.
1994: E P Rock; P R Sibbald; Mark M Davis; Yueh-hsiu Chien
CDR3 length in antigen-specific immune receptors.
The Journal of experimental medicine 1994;179(1):323-8.
1993: Yueh-hsiu Chien; Mark M Davis
How alpha beta T-cell receptors 'see' peptide/MHC complexes.
Immunology today 1993;14(12):597-602.
1993: JJ Boniface; N L Allbritton; P A Reay; R M Kantor; L Stryer; Mark M Davis
pH affects both the mechanism and the specificity of peptide binding to a class II major histocompatibility complex molecule.
Biochemistry 1993;32(44):11761-8.
1993: John D Altman; P A Reay; Mark M Davis
Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):10330-4.
1993: Charles G. Sagerstrom; E M Kerr; James P Allison; Mark M Davis
Activation and differentiation requirements of primary T cells in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):8987-91.
1993: E W Ehrich; B Devaux; E P Rock; J L Jorgensen; Mark M Davis; Yueh-hsiu Chien
T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen.
The Journal of experimental medicine 1993;178(2):713-22.
1993: Paul C Driscoll; John D Altman; JJ Boniface; K Sakaguchi; P A Reay; James G. Omichinski; E Appella; Mark M Davis
Two-dimensional nuclear magnetic resonance analysis of a labeled peptide bound to a class II major histocompatibility complex molecule.
Journal of molecular biology 1993;232(2):342-50.
1993: P A Patten; E P Rock; T Sonoda; B Fazekas de St Groth; J L Jorgensen; Mark M Davis
Transfer of putative complementarity-determining region loops of T cell receptor V domains confers toxin reactivity but not peptide/MHC specificity.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(6):2281-94.
1993: Mark M Davis; Y Chien
Topology and affinity of T-cell receptor mediated recognition of peptide-MHC complexes.
Current opinion in immunology 1993;5(1):45-9.
1992: P A Reay; D A Wettstein; Mark M Davis
pH dependence and exchange of high and low responder peptides binding to a class II MHC molecule.
The EMBO journal 1992;11(8):2829-39.
1992: J L Jorgensen; Ursula Esser; B Fazekas de St Groth; P A Reay; Mark M Davis
Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics.
Nature 1992;355(6357):224-30.
1992: J L Jorgensen; P A Reay; E W Ehrich; Mark M Davis
Molecular components of T-cell recognition.
Annual review of immunology 1992;10():835-73.
1991: K Matsui; JJ Boniface; P A Reay; H Schild; B Fazekas de St Groth; Mark M Davis
Low affinity interaction of peptide-MHC complexes with T cell receptors.
Science (New York, N.Y.) 1991;254(5039):1788-91.
1991: B Devaux; P J Bjorkman; C Stevenson; W Greif; John Elliott; Charles G. Sagerstrom; C Clayberger; Alan Krensky; Mark M Davis
Generation of monoclonal antibodies against soluble human T cell receptor polypeptides.
European journal of immunology 1991;21(9):2111-9.
1991: M Iwashima; Mark M Davis; Yueh-hsiu Chien
A gamma/delta cell receptor heterodimer induces the expression of CD4 and CD8 in thymocytes.
The Journal of experimental medicine 1991;174(1):293-6.
1991: D A Wettstein; JJ Boniface; P A Reay; H Schild; Mark M Davis
Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH.
The Journal of experimental medicine 1991;174(1):219-28.
1991: M Iwashima; A Green; ML Bonyhadi; Mark M Davis; James P Allison; Yueh-hsiu Chien
Expression of a fetal gamma delta T-cell receptor in adult mice triggers a non-MHC-linked form of selective depletion.
International immunology 1991;3(4):385-93.
1990: A Y Lin; B Devaux; A Green; Charles G. Sagerstrom; John Elliott; Mark M Davis
Expression of T cell antigen receptor heterodimers in a lipid-linked form.
Science (New York, N.Y.) 1990;249(4969):677-9.
1990: Leslie J Berg; G D Frank; Mark M Davis
The effects of MHC gene dosage and allelic variation on T cell receptor selection.
Cell 1990;60(6):1043-53.
1990: Alan Krensky; A Weiss; G Crabtree; Mark M Davis; Peter Parham
T-lymphocyte-antigen interactions in transplant rejection.
The New England journal of medicine 1990;322(8):510-7.
1990: Mark M Davis
T cell receptor gene diversity and selection.
Annual review of biochemistry 1990;59():475-96.
1989: H J Garchon; E Loh; W Y Ho; L Amar; Philip Avner; Mark M Davis
The XLR sequence family: dispersion on the X and Y chromosomes of a large set of closely related sequences, most of which are pseudogenes.
Nucleic acids research 1989;17(23):9871-88.
1989: Leslie J Berg; Mark M Davis
T-cell development in T cell receptor alphabeta transgenic mice.
Seminars in immunology 1989;1(2):105-16.
1989: Leslie J Berg; A M Pullen; B Fazekas de St Groth; D Mathis; C Benoist; Mark M Davis
Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.
Cell 1989;58(6):1035-46.
1989: Leslie J Berg; B Fazekas de St Groth; A M Pullen; Mark M Davis
Phenotypic differences between alpha beta versus beta T-cell receptor transgenic mice undergoing negative selection.
Nature 1989;340(6234):559-62.
1989: Mark M Davis; Yueh-hsiu Chien; P J Bjorkman; John Elliott; M Iwashima; E P Rock; P A Patten
A possible basis for major histocompatibility complex-restricted T-cell recognition.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1989;323(1217):521-4.
1989: E Y Loh; John Elliott; S Cwirla; Lewis L Lanier; Mark M Davis
Polymerase chain reaction with single-sided specificity: analysis of T cell receptor delta chain.
Science (New York, N.Y.) 1989;243(4888):217-20.
1989: Mark M Davis; P J Bjorkman
A model for T cell receptor and MHC/peptide interaction.
Advances in experimental medicine and biology 1989;254():13-6.
1989: Mark M Davis; Leslie J Berg; A Y Lin; B Fazekas de St Groth; B Devaux; Charles G. Sagerstrom; P J Bjorkman; John Elliott
TCR recognition and selection in vivo.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():119-28.
1988: Leslie J Berg; B Fazekas de St Groth; F Ivars; C C Goodnow; S Gilfillan; H J Garchon; Mark M Davis
Expression of T-cell receptor alpha-chain genes in transgenic mice.
Molecular and cellular biology 1988;8(12):5459-69.
1988: Jan Jongstra; G F Tidmarsh; Jenny Jongstra-Bilen; Mark M Davis
A new lymphocyte-specific gene which encodes a putative Ca2+-binding protein is not expressed in transformed T lymphocyte lines.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(11):3999-4004.
1988: M Iwashima; A Green; Mark M Davis; Yueh-hsiu Chien
Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):8161-5.
1988: Mark M Davis; P J Bjorkman
T-cell antigen receptor genes and T-cell recognition.
Nature 1988;334(6181):395-402.
1988: Jan Jongstra; Jenny Jongstra-Bilen; G F Tidmarsh; Mark M Davis
The in vitro translation product of the murine lambda 5 gene contains a functional signal peptide.
Molecular immunology 1988;25(8):687-93.
1988: Thomas J Schall; Jan Jongstra; B J Dyer; J Jorgensen; Carol Clayberger; Mark M Davis; Alan Krensky
A human T cell-specific molecule is a member of a new gene family.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(3):1018-25.
1988: N E Lee; Mark M Davis
T cell receptor beta-chain genes in BW5147 and other AKR tumors. Deletion order of murine V beta gene segments and possible 5' regulatory regions.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1665-75.
1988: John Elliott; E P Rock; P A Patten; Mark M Davis; Yueh-hsiu Chien
The adult T-cell receptor delta-chain is diverse and distinct from that of fetal thymocytes.
Nature 1988;331(6157):627-31.
1987: Yueh-hsiu Chien; M Iwashima; D A Wettstein; K B Kaplan; John Elliott; W Born; Mark M Davis
T-cell receptor delta gene rearrangements in early thymocytes.
Nature 1987;330(6150):722-7.
1987: E Y Loh; Lewis L Lanier; Christoph W Turck; Dan R Littman; Mark M Davis; Yueh-hsiu Chien; A Weiss
Identification and sequence of a fourth human T cell antigen receptor chain.
Nature 1987;330(6148):569-72.
1987: T Lindsten; N E Lee; Mark M Davis
Organization of the T-cell antigen-receptor beta-chain locus in mice.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7639-43.
1987: B Hertel-Wulff; T Lindsten; R Schwadron; David M Gilbert; Mark M Davis; Samuel Strober
Rearrangement and expression of T cell receptor genes in cloned murine natural suppressor cell lines.
The Journal of experimental medicine 1987;166(4):1168-73.
1987: Yueh-hsiu Chien; M Iwashima; K B Kaplan; John Elliott; Mark M Davis
A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation.
Nature 1987;327(6124):677-82.
1987: Jan Jongstra; Thomas J Schall; B J Dyer; Carol Clayberger; J Jorgensen; Mark M Davis; Alan Krensky
The isolation and sequence of a novel gene from a human functional T cell line.
The Journal of experimental medicine 1987;165(3):601-14.