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Peg Davis

Research Profile

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Ravil R Petrov; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Josephine Lai; Yeon Sun Lee; Lu Liu; Shou-wu Ma; Peg Davis; Victor J Hruby
Effect of anchoring 4-anilidopiperidines to opioid peptides.
Alec Okun; Michael H Ossipov; Bethany Remeniuk; Jiyang Ren; Jennifer Xie; Triza Brion; Peg Davis; G Dussor; Tamara King; Ping Liu; Frank Porreca
Afferent drive elicits ongoing pain in a model of advanced osteoarthritis.
Ruben Vardanyan; Eva Varga; Peg Davis; Vlad K Kumirov; Josephine Lai; Erika Liktor-Busa; Gary S Nichol; Frank Porreca; David Rankin; Todd W Vanderah; Victor J Hruby
Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.

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All Publications

2013: Ravil R Petrov; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Josephine Lai; Yeon Sun Lee; Lu Liu; Shou-wu Ma; Peg Davis; Victor J Hruby
Effect of anchoring 4-anilidopiperidines to opioid peptides.
Bioorganic & medicinal chemistry letters 2013;23(11):3434-7.
2012: Alec Okun; Michael H Ossipov; Bethany Remeniuk; Jiyang Ren; Jennifer Xie; Triza Brion; Peg Davis; G Dussor; Tamara King; Ping Liu; Frank Porreca
Afferent drive elicits ongoing pain in a model of advanced osteoarthritis.
Pain 2012;153(4):924-33.
2011: Ruben Vardanyan; Eva Varga; Peg Davis; Vlad K Kumirov; Josephine Lai; Erika Liktor-Busa; Gary S Nichol; Frank Porreca; David Rankin; Todd W Vanderah; Victor J Hruby
Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.
Bioorganic & medicinal chemistry 2011;19(20):6135-42.
2011: Takashi Yamamoto; Padma Nair; Tally M Largent-Milnes; Neil E Jacobsen; Peg Davis; Shou-wu Ma; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
Journal of medicinal chemistry 2011;54(7):2029-38.
2011: Yeon Sun Lee; Shou-wu Ma; Frank Porreca; Todd W Vanderah; Ruben Vardanyan; Scott M Cowell; Peg Davis; Katherine E Hanlon; Vinod Kulkarani; Josephine Lai; Victor J Hruby
Development of potent μ and δ opioid agonists with high lipophilicity.
Journal of medicinal chemistry 2011;54(1):382-6.
2010: Yeon Sun Lee; Steve Fernandes; Vinod Kulkarani; Alexander V Mayorov; Peg Davis; Shou-wu Ma; Kathy Brown; Robert J Gillies; Josephine Lai; Frank Porreca; Victor J Hruby
Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain.
Bioorganic & medicinal chemistry letters 2010;20(14):4080-4.
2009: Takashi Yamamoto; Padma Nair; Shou-wu Ma; Peg Davis; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.
Bioorganic & medicinal chemistry 2009;17(20):7337-43.
2009: Takashi Yamamoto; Padma Nair; Neil E Jacobsen; Josef Vagner; Vinod Kulkarni; Peg Davis; Shou-wu Ma; Edita Navratilova; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2009;52(16):5164-75.
2009: Ruben Vardanyan; Gokhale Vijay; Gary S Nichol; Lu Liu; Isuru Kumarasinghe; Peg Davis; Todd W Vanderah; Frank Porreca; Josephine Lai; Victor J Hruby
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.
Bioorganic & medicinal chemistry 2009;17(14):5044-53.
2009: Jatinder S Josan; David L Morse; Liping Xu; Maria Trissal; Brenda Baggett; Peg Davis; Josef Vagner; Robert J Gillies; Victor J Hruby
Solid-phase synthetic strategy and bioevaluation of a labeled delta-opioid receptor ligand Dmt-Tic-Lys for in vivo imaging.
Organic letters 2009;11(12):2479-82.
2009: Padma Nair; Takashi Yamamoto; Vinod Kulkarni; Sharif Moye; Edita Navratilova; Peg Davis; Tally Largent; Shou-wu Ma; Henry I Yamamura; Todd W Vanderah; Josephine Lai; Frank Porreca; Victor J Hruby
Novel bifunctional peptides as opioid agonists and NK-1 antagonists.
Advances in experimental medicine and biology 2009;611():537-8.
2009: YeonSun Lee; Ravil Petrov; Vinod Kulkarni; Byoung J Min; Shou-wu Ma; Peg Davis; Janice Oyarzo; Todd W Vanderah; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety.
Advances in experimental medicine and biology 2009;611():517-8.
2009: Vinod V Kulkarni; Yeon Sun Lee; Christine Salibay; Peg Davis; Shou-wu Ma; Frank Porreca; Victor J Hruby
Novel analogues of bifunctional ligands for opioid and melanocortin 4 receptor.
Advances in experimental medicine and biology 2009;611():195-6.
2008: Takashi Yamamoto; Padma Nair; Neil E Jacobsen; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Josephine Lai; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Victor J Hruby
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2008;51(20):6334-47.
2008: Richard S Agnes; Jinfa Ying; Katalin E Kövér; Yeon Sun Lee; Peg Davis; Shou-wu Ma; Hamid Badghisi; Frank Porreca; Josephine Lai; Victor J Hruby
Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.
Peptides 2008;29(8):1413-23.
2008: Takashi Yamamoto; Padma Nair; Josef Vagner; Tally Largent-Milnes; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Suneeta Tumati; Josephine Lai; Henry I Yamamura; Todd W Vanderah; Frank Porreca; Victor J Hruby
A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Journal of medicinal chemistry 2008;51(5):1369-76.
2008: Yeon Sun Lee; Richard S Agnes; James P Cain; Vinod Kulkarni; Minying Cai; Christine Salibay; Kathy Ciano; Ravil R Petrov; Alexander V Mayorov; Josef Vagner; Dev Trivedi; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Opioid and melanocortin receptors: do they have overlapping pharmacophores?
Biopolymers 2008;90(3):433-8.
2007: Yeon Sun Lee; Ravil R Petrov; chad park; Shou-wu Ma; Peg Davis; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors.
Journal of medicinal chemistry 2007;50(22):5528-32.
2007: Adriano Mollica; Giovanni Guardiani; Peg Davis; Shou-wu Ma; Frank Porreca; Josephine Lai; Luisa Mannina; Anatoli P Sobolev; Victor J Hruby
Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis.
Journal of medicinal chemistry 2007;50(13):3138-42.
2007: Takashi Yamamoto; Padma Nair; Peg Davis; Shou-wu Ma; Edita Navratilova; Sharif Moye; Suneeta Tumati; Josephine Lai; Todd W Vanderah; Henry I Yamamura; Frank Porreca; Victor J Hruby
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
Journal of medicinal chemistry 2007;50(12):2779-86.
2007: Yeon Sun Lee; Joel Nyberg; Sharif Moye; Richard S Agnes; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J Hruby
Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors.
Bioorganic & medicinal chemistry letters 2007;17(8):2161-5.
2007: Yeon Sun Lee; Richard S Agnes; Peg Davis; Shou-wu Ma; Hamid Badghisi; Josephine Lai; Frank Porreca; Victor J Hruby
Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors.
Journal of medicinal chemistry 2007;50(1):165-8.
2007: John J Lowery; Larisa Yeomans; Charles M Keyari; Peg Davis; Frank Porreca; Brian I Knapp; Jean M Bidlack; Edward J Bilsky; Robin Polt
Glycosylation improves the central effects of DAMGO.
Chemical biology & drug design 2007;69(1):41-7.
2006: Ravil R Petrov; Ruben Vardanyan; Yeon S Lee; Shou-wu Ma; Peg Davis; Lucinda J Begay; Josephine Y Lai; Frank Porreca; Victor J Hruby
Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity.
Bioorganic & medicinal chemistry letters 2006;16(18):4946-50.
2006: Richard S Agnes; Yeon Sun Lee; Peg Davis; Shou-wu Ma; Hamid Badghisi; Frank Porreca; Josephine Lai; Victor J Hruby
Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors.
Journal of medicinal chemistry 2006;49(10):2868-75.
2006: Yeon Sun Lee; Richard S Agnes; Hamid Badghisi; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Victor J Hruby
Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists.
Journal of medicinal chemistry 2006;49(5):1773-80.
2006: Adriano Mollica; Peg Davis; Shou-wu Ma; Frank Porreca; Josephine Lai; Victor J Hruby
Synthesis and biological activity of the first cyclic biphalin analogues.
Bioorganic & medicinal chemistry letters 2006;16(2):367-72.
2006: Victor J Hruby; Frank Porreca; Henry I Yamamura; Gordon Tollin; Richard S Agnes; Yeon Sun Lee; Minying Cai; Isabel D Alves; Scott M Cowell; Eva Varga; Peg Davis; Zdzislaw Salamon; William R Roeske; Todd W Vanderah; Josephine Lai
New paradigms and tools in drug design for pain and addiction.
The AAPS journal 2006;8(3):E450-60.
2005: Adriano Mollica; Peg Davis; Shou-wu Ma; Josephine Lai; Frank Porreca; Victor J Hruby
Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers.
Bioorganic & medicinal chemistry letters 2005;15(10):2471-5.
2005: Muthu Dhanasekaran; Michael M Palian; Isabel D Alves; Larisa Yeomans; Charles M Keyari; Peg Davis; Edward J Bilsky; Richard D Egleton; Henry I Yamamura; Neil E Jacobsen; Gordon Tollin; Victor J Hruby; Frank Porreca; Robin Polt
Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers.
Journal of the American Chemical Society 2005;127(15):5435-48.
2005: Xuyuan Gu; Jinfa Ying; Byoung Min; James P Cain; Peg Davis; Patrick Willey; Edita Navratilova; Henry I Yamamura; Frank Porreca; Victor J Hruby
Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]-Leu-enkephalin analogues.
Biopolymers 2005;80(2-3):151-63.
2004: Nura O Elmagbari; Richard D Egleton; Michael M Palian; John J Lowery; Wendi R Schmid; Peg Davis; Edita Navratilova; Muthu Dhanasekaran; Charles M Keyari; Henry I Yamamura; Frank Porreca; Victor J Hruby; Robin Polt; Edward J Bilsky
Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides.
The Journal of pharmacology and experimental therapeutics 2004;311(1):290-7.
2004: Xuyuan Gu; Jinfa Ying; Richard S Agnes; Edita Navratilova; Peg Davis; Gannon Stahl; Frank Porreca; Henry I Yamamura; Victor J Hruby
Novel design of bicyclic beta-turn dipeptides on solid-phase supports and synthesis of [3.3.0]-Bicyclo([2,3])-leu-enkephalin analogues.
Organic letters 2004;6(19):3285-8.
2004: Isabel D Alves; Scott M Cowell; Yeon Sun Lee; Xuejun Tang; Peg Davis; Frank Porreca; Victor J Hruby
A novel 3-step enantioselective synthesis of pyrenylalanine with subsequent incorporation into opioid, CCK, and melanotropin ligands.
Biochemical and biophysical research communications 2004;318(2):335-40.
2003: Chiyi Xiong; Junyi Zhang; Peg Davis; Wei Wang; Jinfa Ying; Frank Porreca; Victor J Hruby
Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted beta-turn bicyclic dipeptide mimetics.
Chemical communications (Cambridge, England) 2003;(13):1598-9.
2003: Victor J Hruby; Richard S Agnes; Peg Davis; Shou-wu Ma; Yeon Sun Lee; Todd W Vanderah; Josephine Lai; Frank Porreca
Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain.
Life sciences 2003;73(6):699-704.
2001: S Liao; MD Shenderovich; Katalin E Kövér; Z Zhang; Keiko Hosohata; Peg Davis; Frank Porreca; Henry I Yamamura; V J Hurby
Synthesis, biology, NMR and conformation studies of the topographically constrained delta-opioid selective peptide analogs of [beta-iPrPhe(3)]deltorphin I.
The journal of peptide research : official journal of the American Peptide Society 2001;57(4):257-76.
2001: Andrzej W Lipkowski; Aleksandra Misicka; Keiko Hosohata; Peg Davis; Henry I Yamamura; Frank Porreca; Victor J Hruby
Biological properties of Phe(o)-opioid peptide analogues.
Life sciences 2001;68(8):969-72.
2000: Edward J Bilsky; Richard D Egleton; SA Mitchell; Michael M Palian; Peg Davis; Jason D Huber; H Jones; Henry I Yamamura; J Janders; Thomas P Davis; Frank Porreca; Victor J Hruby; Robin Polt
Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability.
Journal of medicinal chemistry 2000;43(13):2586-90.
2000: Gregg Bonner; Peg Davis; Dagmar Stropova; S Edsall; Henry I Yamamura; Frank Porreca; Victor J Hruby
Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays.
Journal of medicinal chemistry 2000;43(4):569-80.
1999: Josue Alfaro-Lopez; Toru Okayama; Keiko Hosohata; Peg Davis; Frank Porreca; Henry I Yamamura; Victor J Hruby
Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand.
Journal of medicinal chemistry 1999;42(26):5359-68.
1999: Andrzej W Lipkowski; Aleksandra Misicka; Peg Davis; Dagmar Stropova; J Janders; M Lachwa; Frank Porreca; Henry I Yamamura; Victor J Hruby
Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin.
Bioorganic & medicinal chemistry letters 1999;9(18):2763-6.
1999: H Bartosz-Bechowski; Peg Davis; J Slaninova; Ewa Malatynska; Dagmar Stropova; Frank Porreca; Henry I Yamamura; Victor J Hruby
Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors.
The journal of peptide research : official journal of the American Peptide Society 1999;53(3):329-36.
1998: S Liao; Josue Alfaro-Lopez; MD Shenderovich; Keiko Hosohata; J Lin; X Li; Dagmar Stropova; Peg Davis; K A Jernigan; Frank Porreca; Henry I Yamamura; Victor J Hruby
De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor.
Journal of medicinal chemistry 1998;41(24):4767-76.
1998: G Li; W Haq; L Xiang; B S Lou; R Hughes; I A De Leon; Peg Davis; TJ Gillespie; Marek Romanowski; Xiaoyun Zhu; Aleksandra Misicka; Andrzej W Lipkowski; Frank Porreca; Thomas P Davis; Henry I Yamamura; David F O'Brien; Victor J Hruby
Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide.
Bioorganic & medicinal chemistry letters 1998;8(5):555-60.
1997: Victor J Hruby; H Bartosz-Bechowski; Peg Davis; J Slaninova; Teresa Zalewska; Dagmar Stropova; Frank Porreca; Henry I Yamamura
Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.
Journal of medicinal chemistry 1997;40(24):3957-62.
1997: R C Haaseth; Teresa Zalewska; Peg Davis; Henry I Yamamura; Frank Porreca; Victor J Hruby
Para-substituted phenylalanine-4 analogues of [L-Ala3]DPDPE: highly selective delta opioid receptor ligands.
The journal of peptide research : official journal of the American Peptide Society 1997;50(3):171-7.
1997: Aleksandra Misicka; S Cavagnero; R Horvath; Peg Davis; Frank Porreca; Henry I Yamamura; Victor J Hruby
Synthesis and biological properties of beta-MePhe3 analogues of deltorphin I and dermenkephalin: influence of biased chi 1 Phe3 residues on peptide recognition for delta-opioid receptors.
The journal of peptide research : official journal of the American Peptide Society 1997;50(1):48-54.
1997: Gregg Bonner; Peg Davis; Dagmar Stropova; R Ferguson; Henry I Yamamura; Frank Porreca; Victor J Hruby
Opioid peptides: simultaneous delta agonism and mu antagonism in somatostatin analogues.
Peptides 1997;18(1):93-100.
1997: Aleksandra Misicka; Andrzej W Lipkowski; R Horvath; Peg Davis; Frank Porreca; Henry I Yamamura; Victor J Hruby
Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4.
Life sciences 1997;60(15):1263-9.