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Amnon Altman

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Kok-Fai Kong; Amnon Altman
In and out of the bull's eye: protein kinase Cs in the immunological synapse.
Elizabeth Yan Zhang; Kok-Fai Kong; Amnon Altman
The Yin and Yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression.
Sonia Feau; Stephen P Schoenberger; Amnon Altman; Stéphane Bécart
SLAT regulates CD8+ T cell clonal expansion in a Cdc42- and NFAT1-dependent manner.

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All Publications

2013: Kok-Fai Kong; Amnon Altman
In and out of the bull's eye: protein kinase Cs in the immunological synapse.
Trends in immunology 2013;34(5):234-42.
2013: Elizabeth Yan Zhang; Kok-Fai Kong; Amnon Altman
The Yin and Yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression.
Advances in pharmacology (San Diego, Calif.) 2013;66():267-312.
2013: Sonia Feau; Stephen P Schoenberger; Amnon Altman; Stéphane Bécart
SLAT regulates CD8+ T cell clonal expansion in a Cdc42- and NFAT1-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(1):174-83.
2012: Amnon Altman; Kok-Fai Kong
PKCθ: a new target for selective immunosuppression.
Expert review of clinical immunology 2012;8(3):205-8.
2012: Noah Isakov; Amnon Altman
PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors.
Frontiers in immunology 2012;3():273.
2011: Kok-Fai Kong; Takashi Saito; Tadashi Yokosuka; Ann J Canonigo-Balancio; Noah Isakov; Amnon Altman
A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28.
Nature immunology 2011;12(11):1105-12.
2011: Amnon Altman; Kok-Fai Kong
To kill, you have to duck an HDAC.
Nature immunology 2011;12(4):279-81.
2011: Takanori So; pejman Soroosh; So-Young Eun; Amnon Altman; Michael Croft
Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(7):2903-8.
2011: Nadejda Ladygina; Brent R Martin; Amnon Altman
Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy.
Advances in immunology 2011;109():1-44.
2010: Ariel Ohayon; Jacob Golenser; Rosa Sinay; Ami Tamir; Amnon Altman; Yaakov Pollack; Noah Isakov
Protein kinase C θ deficiency increases resistance of C57BL/6J mice to Plasmodium berghei infection-induced cerebral malaria.
Infection and immunity 2010;78(10):4195-205.
2010: Ariel Ohayon; Yael Babichev; Moran Galperin; Amnon Altman; Noah Isakov
Widespread expression of PICOT in mouse and human tissues with predominant localization to epithelium.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2010;58(9):799-806.
2010: Ariel Ohayon; Yael Babichev; Ronit Pasvolsky; Guangyu Dong; Ignacio Sztarkier; Daniel Benharroch; Amnon Altman; Noah Isakov
Hodgkin's lymphoma cells exhibit high expression levels of the PICOT protein.
Journal of immunotoxicology 2010;7(1):8-14.
2009: Ann J Canonigo-Balancio; Camille Fos; Thomas Prod'homme; Stéphane Bécart; Amnon Altman
SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):7259-67.
2009: Stéphane Bécart; Amnon Altman
SWAP-70-like adapter of T cells: a novel Lck-regulated guanine nucleotide exchange factor coordinating actin cytoskeleton reorganization and Ca2+ signaling in T cells.
Immunological reviews 2009;232(1):319-33.
2009: Amnon Altman; Gary A Koretzky; Constantine D Tsoukas
Navigating the leukocyte signaling maze guided by Ariadne's thread.
Nature immunology 2009;10(11):1134-6.
2009: Matthias Hundt; Yohsuke Harada; Lauren De Giorgio; Natsuko Tanimura; Weiguo Zhang; Amnon Altman
Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1685-94.
2009: Sagit Cohen; Alex Braiman; George Shubinsky; Ariel Ohayon; Amnon Altman; Noah Isakov
PKCtheta is required for hemostasis and positive regulation of thrombin-induced platelet aggregation and alpha-granule secretion.
Biochemical and biophysical research communications 2009;385(1):22-7.
2008: Stéphane Bécart; Ann J Canonigo Balancio; Céline Charvet; Sonia Feau; Caitlin E Sedwick; Amnon Altman
Tyrosine-phosphorylation-dependent translocation of the SLAT protein to the immunological synapse is required for NFAT transcription factor activation.
Immunity 2008;29(5):704-19.
2007: Stéphane Bécart; Céline Charvet; Ann J Canonigo Balancio; Carl De Trez; Yoshihiko Tanaka; Wei Duan; Carl Ware; Michael Croft; Amnon Altman
SLAT regulates Th1 and Th2 inflammatory responses by controlling Ca2+/NFAT signaling.
The Journal of clinical investigation 2007;117(8):2164-75.
2007: Keitaro Hayashi; Amnon Altman
Protein kinase C theta (PKCtheta): a key player in T cell life and death.
Pharmacological research : the official journal of the Italian Pharmacological Society 2007;55(6):537-44.
2006: Céline Charvet; Ann Janette Canonigo; Stéphane Bécart; Ulrich Maurer; Ana V Miletic; Wojciech Swat; Marcel Deckert; Amnon Altman
Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5024-31.
2006: Keitaro Hayashi; Amnon Altman
Filamin A is required for T cell activation mediated by protein kinase C-theta.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1721-8.
2006: Matthias Hundt; Hiroki Tabata; Myung-Shin Jeon; Keitaro Hayashi; Yoshihiko Tanaka; Roma Krishna; Lauren De Giorgio; Yun-Cai Liu; Masaki Fukata; Amnon Altman
Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect.
Immunity 2006;24(5):513-22.
2006: Konstantina Nika; Céline Charvet; Scott Williams; Lutz Tautz; Shane Bruckner; Souad Rahmouni; Nunzio Bottini; Stephen P Schoenberger; Gottfried Baier; Amnon Altman; Tomas Mustelin
Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation.
Molecular and cellular biology 2006;26(5):1806-16.
2006: Rina Barouch-Bentov; Amnon Altman
Protein kinase C-theta (PKCtheta): new perspectives on its functions in T cell biology.
Advances in experimental medicine and biology 2006;584():1-13.
2005: Rina Barouch-Bentov; Edward E Lemmens; Junru Hu; edith janssen; Nathalie M Droin; Jim (Jianxun) Song; Stephen P Schoenberger; Amnon Altman
Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5126-34.
2005: Yoshihiko Tanaka; Takanori So; Svetlana Lebedeva; Michael Croft; Amnon Altman
Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice.
Blood 2005;106(4):1286-95.
2005: Céline Charvet; Ann Janette Canonigo; Daniel D Billadeau; Amnon Altman
Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.
The Journal of biological chemistry 2005;280(15):15289-99.
2005: Isabelle Foucault; Séverine Le Bras; Céline Charvet; Chéol Moon; Amnon Altman; Marcel Deckert
The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor.
Blood 2005;105(3):1106-13.
2005: Yingqiu Li; Caitlin E Sedwick; Junru Hu; Amnon Altman
Role for protein kinase Ctheta (PKCtheta) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-kappaB activation.
The Journal of biological chemistry 2005;280(2):1217-23.
2004: Caitlin E Sedwick; Amnon Altman
Perspectives on PKCtheta in T cell activation.
Molecular immunology 2004;41(6-7):675-86.
2004: Amnon Altman; Sandra Kaminski; Valere Busuttil; Nathalie M Droin; Junru Hu; Yuri Tadevosyan; Robert A Hipskind; Martin Villalba
Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway.
European journal of immunology 2004;34(7):2001-11.
2004: Sandra Kaminski; M A Del Pozo; Robert A Hipskind; Amnon Altman; Martin Villalba
Distinct functions of Vav1 in JNK1 activation in Jurkat T cells versus non-haematopoietic cells.
Scandinavian journal of immunology 2004;59(6):527-35.
2004: Yingqiu Li; Junru Hu; Randi Vita; Binggang Sun; Hiroki Tabata; Amnon Altman
SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway.
The EMBO journal 2004;23(5):1112-22.
2003: Amnon Altman; Martin Villalba
Protein kinase C-theta (PKCtheta): it's all about location, location, location.
Immunological reviews 2003;192():53-63.
2003: Yoshihiko Tanaka; Kun Bi; Rika Kitamura; Sooji Hong; Yoav Altman; Akira Matsumoto; Hiroki Tabata; Svetlana Lebedeva; Paul J Bushway; Amnon Altman
SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells.
Immunity 2003;18(3):403-14.
2003: Miguel A Del Pozo; Martin A Schwartz; Junru Hu; William B Kiosses; Amnon Altman; Martin Villalba
Guanine exchange-dependent and -independent effects of Vav1 on integrin-induced T cell spreading.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):41-7.
2002: Amnon Altman; Martin Villalba
Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death.
Journal of biochemistry 2002;132(6):841-6.
2002: Martin Villalba; Amnon Altman
Protein kinase C-theta (PKCtheta), a potential drug target for therapeutic intervention with human T cell leukemias.
Current cancer drug targets 2002;2(2):125-37.
2002: Martin Villalba; Kun Bi; Junru Hu; Yoav Altman; Paul J Bushway; Eric Reits; Jacques Neefjes; Gottfried Baier; Robert T Abraham; Amnon Altman
Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C.
The Journal of cell biology 2002;157(2):253-63.
2002: Osamu Kaminuma; Chris Elly; Yoshihiko Tanaka; Akio Mori; Yun-Cai Liu; Amnon Altman; Shoichiro Miyatake
Vav-induced activation of the human IFN-gamma gene promoter is mediated by upregulation of AP-1 activity.
FEBS letters 2002;514(2-3):153-8.
2002: Caitlin E Sedwick; Amnon Altman
Ordered just so: lipid rafts and lymphocyte function.
Science's STKE : signal transduction knowledge environment 2002;2002(122):re2.
2002: Noah Isakov; Amnon Altman
Protein kinase C(theta) in T cell activation.
Annual review of immunology 2002;20():761-94.
2002: Nan Fang; Deyu Fang; Hong-Ying Wang; Amnon Altman; Yun-Cai Liu
Regulation of immune responses by E3 ubiquitin-protein ligases.
Current directions in autoimmunity 2002;5():161-75.
2001: Martin Villalba; Kun Bi; F Rodriguez; Yoshihiko Tanaka; Stephen P Schoenberger; Amnon Altman
Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells.
The Journal of cell biology 2001;155(3):331-8.
2001: Sophie Tartare-Deckert; Marie-Noëlle Monthouel; Céline Charvet; Isabelle Foucault; Emmanuel Van Obberghen; Alain Bernard; Amnon Altman; Marcel Deckert
Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte.
The Journal of biological chemistry 2001;276(24):20849-57.
2001: Kun Bi; Yoshihiko Tanaka; N Coudronniere; K Sugie; S Hong; M J van Stipdonk; Amnon Altman
Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation.
Nature immunology 2001;2(6):556-63.
2001: Martin Villalba; Paul J Bushway; Amnon Altman
Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):5955-63.
2001: Osamu Kaminuma; Marcel Deckert; Chris Elly; Yun-Cai Liu; Amnon Altman
Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter.
Molecular and cellular biology 2001;21(9):3126-36.
2001: Kun Bi; Amnon Altman
Membrane lipid microdomains and the role of PKCtheta in T cell activation.
Seminars in immunology 2001;13(2):139-46.
2000: Amnon Altman; N Isakov; G Baier
Protein kinase Ctheta: a new essential superstar on the T-cell stage.
Immunology today 2000;21(11):567-73.
2000: N Isakov; S Witte; Amnon Altman
PICOT-HD: a highly conserved protein domain that is often associated with thioredoxin and glutaredoxin modules.
Trends in biochemical sciences 2000;25(11):537-9.
2000: Martin Villalba; J Hernandez; Marcel Deckert; Yoshihiko Tanaka; Amnon Altman
Vav modulation of the Ras/MEK/ERK signaling pathway plays a role in NFAT activation and CD69 up-regulation.
European journal of immunology 2000;30(6):1587-96.
2000: N Coudronniere; Martin Villalba; N Englund; Amnon Altman
NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3394-9.
2000: Y Liu; S Witte; Yun-Cai Liu; M Doyle; Chris Elly; Amnon Altman
Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation.
The Journal of biological chemistry 2000;275(5):3603-9.
2000: Martin Villalba; N Coudronniere; Marcel Deckert; E Teixeiro; Paloma Mas; Amnon Altman
A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.
Immunity 2000;12(2):151-60.
2000: S Witte; M Villalba; K Bi; Y Liu; N Isakov; Amnon Altman
Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain.
The Journal of biological chemistry 2000;275(3):1902-9.
1999: Y Liu; Yun-Cai Liu; N Meller; L Giampa; Chris Elly; M Doyle; Amnon Altman
Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7095-101.
1999: S Kasibhatla; Pankaj Tailor; N Bonefoy-Berard; Tomas Mustelin; Amnon Altman; Arun Fotedar
Jun kinase phosphorylates and regulates the DNA binding activity of an octamer binding protein, T-cell factor beta1.
Molecular and cellular biology 1999;19(3):2021-31.
1999: Z Zhang; Chris Elly; Amnon Altman; Yun-Cai Liu
Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.
The Journal of biological chemistry 1999;274(8):4883-9.
1999: Chris Elly; S Witte; Z Zhang; O Rosnet; S Lipkowitz; Amnon Altman; Yun-Cai Liu
Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.
Oncogene 1999;18(5):1147-56.
1999: Amnon Altman; M Deckert
The function of small GTPases in signaling by immune recognition and other leukocyte receptors.
Advances in immunology 1999;72():1-101.
1999: I Yron; Marcel Deckert; M E Reff; A Munshi; Martin A Schwartz; Amnon Altman
Integrin-dependent tyrosine phosphorylation and growth regulation by Vav.
Cell adhesion and communication 1999;7(1):1-11.
1998: Marcel Deckert; Sophie Tartare-Deckert; J Hernandez; R Rottapel; Amnon Altman
Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation.
Immunity 1998;9(5):595-605.
1998: Yun-Cai Liu; Amnon Altman
Cbl: complex formation and functional implications.
Cellular signalling 1998;10(6):377-85.
1998: Marcel Deckert; Chris Elly; Amnon Altman; Yun-Cai Liu
Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.
The Journal of biological chemistry 1998;273(15):8867-74.
1998: N Meller; Amnon Altman; Noah Isakov
New perspectives on PKCtheta, a member of the novel subfamily of protein kinase C.
Stem cells (Dayton, Ohio) 1998;16(3):178-92.
1997: T L Collins; Marcel Deckert; Amnon Altman
Views on Vav.
Immunology today 1997;18(5):221-5.
1997: Yun-Cai Liu; Y Liu; Chris Elly; H Yoshida; S Lipkowitz; Amnon Altman
Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif.
The Journal of biological chemistry 1997;272(15):9979-85.
1997: Scott Williams; Clément Couture; J Gilman; Thomas Jascur; Marcel Deckert; Amnon Altman; Tomas Mustelin
Reconstitution of T cell antigen receptor-induced Erk2 kinase activation in Lck-negative JCaM1 cells by Syk.
European journal of biochemistry / FEBS 1997;245(1):84-90.
1997: Yun-Cai Liu; Chris Elly; W Y Langdon; Amnon Altman
Ras-dependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells.
The Journal of biological chemistry 1997;272(1):168-73.
1996: Marcel Deckert; S Tartare-Deckert; Clément Couture; Tomas Mustelin; Amnon Altman
Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product.
Immunity 1996;5(6):591-604.
1996: N Meller; Yun-Cai Liu; T L Collins; N Bonnefoy-Bérard; Gottfried Baier; Noah Isakov; Amnon Altman
Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function.
Molecular and cellular biology 1996;16(10):5782-91.
1996: Clément Couture; Marcel Deckert; Scott Williams; F O Russo; Amnon Altman; Tomas Mustelin
Identification of the site in the Syk protein tyrosine kinase that binds the SH2 domain of Lck.
The Journal of biological chemistry 1996;271(39):24294-9.
1996: N Bonnefoy-Bérard; A Munshi; I Yron; S Wu; T L Collins; Marcel Deckert; T Shalom-Barak; L Giampa; E Herbert; J Hernandez; N Meller; Clément Couture; Amnon Altman
Vav: function and regulation in hematopoietic cell signaling.
Stem cells (Dayton, Ohio) 1996;14(3):250-68.
1996: M Von Willebrand; Thomas Jascur; N Bonnefoy-Bérard; H Yano; Amnon Altman; Y Matsuda; Tomas Mustelin
Inhibition of phosphatidylinositol 3-kinase blocks T cell antigen receptor/CD3-induced activation of the mitogen-activated kinase Erk2.
European journal of biochemistry / FEBS 1996;235(3):828-35.
1995: N Bonnefoy-Bérard; Yun-Cai Liu; M von Willebrand; A Sung; Chris Elly; Tomas Mustelin; H Yoshida; KIMISHIGE ISHIZAKA; Amnon Altman
Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10142-6.
1995: Tomas Mustelin; Scott Williams; Pankaj Tailor; Clément Couture; G Zenner; P Burn; J D Ashwell; Amnon Altman
Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase.
European journal of immunology 1995;25(4):942-6.
1995: Gabriele Baier-Bitterlich; Gottfried Baier; Erich Gulbins; K Mark Coggeshall; Amnon Altman
The role of p56lck in CD4-mediated suppression of CD3-induced early signaling events in T lymphocytes.
Life sciences 1995;56(15):1287-97.
1994: D Galron; A Tamir; Amnon Altman; Noah Isakov
Inhibition of PMA-induced human T cell proliferation by bryostatin is associated with enhanced degradation of conventional protein kinase C (cPKC): Ca2+ signals restore mitogenic activity without abrogating enhanced cPKC degradation.
Cellular immunology 1994;158(1):195-207.
1994: Gottfried Baier; Gabriele Baier-Bitterlich; N Meller; K Mark Coggeshall; L Giampa; D Telford; Noah Isakov; Amnon Altman
Expression and biochemical characterization of human protein kinase C-theta.
European journal of biochemistry / FEBS 1994;225(1):195-203.
1994: Gottfried Baier; K Mark Coggeshall; Gabriele Baier-Bitterlich; L Giampa; D Telford; E Herbert; W Shih; Amnon Altman
Construction and characterization of lck- and fyn-specific tRNA: ribozyme chimeras.
Molecular immunology 1994;31(12):923-32.
1994: Clément Couture; Gottfried Baier; C Oetken; Scott Williams; D Telford; A Marie-Cardine; Gabriele Baier-Bitterlich; S Fischer; P Burn; Amnon Altman
Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation.
Molecular and cellular biology 1994;14(8):5249-58.
1994: Gottfried Baier; Gabriele Baier-Bitterlich; Clément Couture; D Telford; L Giampa; Amnon Altman
An efficient expression, purification and immunodetection system for recombinant gene products.
BioTechniques 1994;17(1):94, 96, 98-9.
1994: Erich Gulbins; K Mark Coggeshall; Gottfried Baier; D Telford; C Langlet; Gabriele Baier-Bitterlich; N Bonnefoy-Berard; P Burn; A Wittinghofer; Amnon Altman
Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides.
Molecular and cellular biology 1994;14(7):4749-58.
1994: Clément Couture; Gottfried Baier; Amnon Altman; Tomas Mustelin
p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5301-5.
1994: Erich Gulbins; C Langlet; Gottfried Baier; N Bonnefoy-Berard; E Herbert; Amnon Altman; K Mark Coggeshall
Tyrosine phosphorylation and activation of Vav GTP/GDP exchange activity in antigen receptor-triggered B cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2123-9.
1994: Erich Gulbins; K Mark Coggeshall; C Langlet; Gottfried Baier; N Bonnefoy-Berard; P Burn; A Wittinghofer; S Katzav; Amnon Altman
Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein.
Molecular and cellular biology 1994;14(2):906-13.
1994: Amnon Altman
Abnormal antigen receptor-initiated signal transduction in lpr T lymphocytes.
Seminars in immunology 1994;6(1):9-17.
1993: Erich Gulbins; K Mark Coggeshall; Gottfried Baier; S Katzav; P Burn; Amnon Altman
Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation.
Science (New York, N.Y.) 1993;260(5109):822-5.
1993: Gottfried Baier; D Telford; Erich Gulbins; N Yamada; T Kawakami; Amnon Altman
Improved specificity of RT-PCR amplifications using nested cDNA primers.
Nucleic acids research 1993;21(5):1329-30.
1993: Gottfried Baier; D Telford; L Giampa; K Mark Coggeshall; Gabriele Baier-Bitterlich; Noah Isakov; Amnon Altman
Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells.
The Journal of biological chemistry 1993;268(7):4997-5004.
1993: Noah Isakov; D Galron; T Mustelin; George R Pettit; Amnon Altman
Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(4):1195-204.
1992: Noah Isakov; M I Mally; Amnon Altman
Mitogen-induced human T cell proliferation is associated with increased expression of selected PKC genes.
Molecular immunology 1992;29(7-8):927-33.
1992: Amnon Altman; M I Mally; Noah Isakov
Phorbol ester synergizes with Ca2+ ionophore in activation of protein kinase C (PKC)alpha and PKC beta isoenzymes in human T cells and in induction of related cellular functions.
Immunology 1992;76(3):465-71.
1992: K Mark Coggeshall; J C McHugh; Amnon Altman
Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5660-4.
1991: Noah Isakov; Jacob Gopas; E Priel; S Segal; Amnon Altman
Effect of protein kinase C activating tumor promoters on metastases formation by fibrosarcoma cells.
Invasion & metastasis 1991;11(1):14-24.
1990: T Mustelin; Amnon Altman
Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45).
Oncogene 1990;5(6):809-13.
1990: T Mustelin; K M Coggeshall; N Isakov; Amnon Altman
T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation.
Science (New York, N.Y.) 1990;247(4950):1584-7.
1990: Noah Isakov; P McMahon; Amnon Altman
Selective post-transcriptional down-regulation of protein kinase C isoenzymes in leukemic T cells chronically treated with phorbol ester.
The Journal of biological chemistry 1990;265(4):2091-7.
1990: Amnon Altman; T Mustelin; K M Coggeshall
T lymphocyte activation: a biological model of signal transduction.
Critical reviews in immunology 1990;10(4):347-91.
1990: Amnon Altman; K M Coggeshall; T Mustelin
Molecular events mediating T cell activation.
Advances in immunology 1990;48():227-360.
1989: T Mustelin; K M Coggeshall; Amnon Altman
Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(16):6302-6.
1988: Wolfgang Scholz; Noah Isakov; M I Mally; Argyrios N Theofilopoulos; Amnon Altman
Lpr T cell hyporesponsiveness to mitogens linked to deficient receptor-stimulated phosphoinositide hydrolysis.
The Journal of biological chemistry 1988;263(8):3626-31.
1988: Michael B McChesney; Amnon Altman; M B Oldstone
Suppression of T lymphocyte function by measles virus is due to cell cycle arrest in G1.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(4):1269-73.
1987: Noah Isakov; M I Mally; Wolfgang Scholz; Amnon Altman
T-lymphocyte activation: the role of protein kinase C and the bifurcating inositol phospholipid signal transduction pathway.
Immunological reviews 1987;95():89-111.