Roger Davis

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Standen Claire L; Kennedy Norman J; Flavell Richard A; Davis Roger J
Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes.
Morel Caroline; Carlson Scott M; White Forest M; Davis Roger J
Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis.
Rincón Mercedes; Davis Roger J
Regulation of the immune response by stress-activated protein kinases.

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All Publications

2009: Standen Claire L; Kennedy Norman J; Flavell Richard A; Davis Roger J
Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes.
Molecular and cellular biology 2009;29(17):4831-40.
2009: Morel Caroline; Carlson Scott M; White Forest M; Davis Roger J
Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis.
Molecular and cellular biology 2009;29(14):3845-52.
2009: Rincón Mercedes; Davis Roger J
Regulation of the immune response by stress-activated protein kinases.
Immunological reviews 2009;228(1):212-24.
2009: Das Madhumita; Sabio Guadalupe; Jiang Feng; Rincón Mercedes; Flavell Richard A; Davis Roger J
Induction of hepatitis by JNK-mediated expression of TNF-alpha.
Cell 2009;136(2):249-60.
2008: Sabio Guadalupe; Das Madhumita; Mora Alfonso; Zhang Zhiyou; Jun John Y; Ko Hwi Jin; Barrett Tamera; Kim Jason K; Davis Roger J
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance.
Science (New York, N.Y.) 2008;322(5907):1539-43.
2008: Fitzgerald T J; Wang Tao; Goel Hira Lal; Huang Jiayi; Stein Gary; Lian Jane; Davis Roger J; Doxsey Steven; Balaji K C; Aronowitz Jesse; Languino Lucia R
Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention.
Expert review of anticancer therapy 2008;8(6):967-74.
2008: Hübner Anette; Barrett Tamera; Flavell Richard A; Davis Roger J
Multisite phosphorylation regulates Bim stability and apoptotic activity.
Molecular cell 2008;30(4):415-25.
2008: Thornton Tina M; Pedraza-Alva Gustavo; Deng Bin; Wood C David; Aronshtam Alexander; Clements James L; Sabio Guadalupe; Davis Roger J; Matthews Dwight E; Doble Bradley; Rincon Mercedes
Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.
Science (New York, N.Y.) 2008;320(5876):667-70.
2008: Alcorn John F; Guala Amy S; van der Velden Jos; McElhinney Brian; Irvin Charles G; Davis Roger J; Janssen-Heininger Yvonne M W
Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1.
Journal of cell science 2008;121(Pt 7):1036-45.
2008: Pedra Joao H F; Mattner Jochen; Tao Jian; Kerfoot Steven M; Davis Roger J; Flavell Richard A; Askenase Philip W; Yin Zhinan; Fikrig Erol
c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection.
Infection and immunity 2008;76(1):308-16.
2007: Das Madhumita; Jiang Feng; Sluss Hayla K; Zhang Chao; Shokat Kevan M; Flavell Richard A; Davis Roger J
Suppression of p53-dependent senescence by the JNK signal transduction pathway.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(40):15759-64.
2007: Kennedy Norman J; Martin Gilles; Ehrhardt Anka G; Cavanagh-Kyros Julie; Kuan Chia-Yi; Rakic Pasko; Flavell Richard A; Treistman Steven N; Davis Roger J
Requirement of JIP scaffold proteins for NMDA-mediated signal transduction.
Genes & development 2007;21(18):2336-46.
2007: Mishra Ashwini K; Gangwani Laxman; Davis Roger J; Lambright David G
Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):13930-5.
2007: Jaeschke Anja; Davis Roger J
Metabolic stress signaling mediated by mixed-lineage kinases.
Molecular cell 2007;27(3):498-508.
2007: Allen Jasmina J; Li Manqing; Brinkworth Craig S; Paulson Jennifer L; Wang Dan; Hübner Anette; Chou Wen-Hai; Davis Roger J; Burlingame Alma L; Messing Robert O; Katayama Carol D; Hedrick Stephen M; Shokat Kevan M
A semisynthetic epitope for kinase substrates.
Nature methods 2007;4(6):511-6.
2007: Weston Claire R; Davis Roger J
The JNK signal transduction pathway.
Current opinion in cell biology 2007;19(2):142-9.
2007: Tao Jian; Gao Yunfei; Li Ming O; He Weifeng; Chen Liang; Harvev Bohdan; Davis Roger J; Flavell Richard A; Yin Zhinan
JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response.
European journal of immunology 2007;37(3):818-29.
2007: Kennedy Norman J; Cellurale Cristina; Davis Roger J
A radical role for p38 MAPK in tumor initiation.
Cancer cell 2007;11(2):101-3.
2006: Hübner Anette; Jaeschke Anja; Davis Roger J
Oncogene addiction: role of signal attenuation.
Developmental cell 2006;11(6):752-4.
2006: Liao Guanghong; Tao Qinghua; Kofron Matthew; Chen Juei-Suei; Schloemer Aryn; Davis Roger J; Hsieh Jen-Chih; Wylie Chris; Heasman Janet; Kuan Chia-Yi
Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16313-8.
2006: Groisman Irina; Ivshina Maria; Marin Veronica; Kennedy Norman J; Davis Roger J; Richter Joel D
Control of cellular senescence by CPEB.
Genes & development 2006;20(19):2701-12.
2006: Jaeschke Anja; Karasarides Maria; Ventura Juan-Jose; Ehrhardt Anka; Zhang Chao; Flavell Richard A; Shokat Kevan M; Davis Roger J
JNK2 is a positive regulator of the cJun transcription factor.
Molecular cell 2006;23(6):899-911.
2006: Tran Elise H; Azuma Yasu-Taka; Chen Manchuan; Weston Claire; Davis Roger J; Flavell Richard A
Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(36):13451-6.
2006: Adhami Faisal; Liao Guanghong; Morozov Yury M; Schloemer Aryn; Schmithorst Vincent J; Lorenz John N; Dunn R Scott; Vorhees Charles V; Wills-Karp Marsha; Degen Jay L; Davis Roger J; Mizushima Noboru; Rakic Pasko; Dardzinski Bernard J; Holland Scott K; Sharp Frank R; Kuan Chia-Yi
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy.
The American journal of pathology 2006;169(2):566-83.
2006: Sluss Hayla K; Davis Roger J
H2AX is a target of the JNK signaling pathway that is required for apoptotic DNA fragmentation.
Molecular cell 2006;23(2):152-3.
2006: Doran Beth; Gherbesi Norberto; Hendricks Gregory; Flavell Richard A; Davis Roger J; Gangwani Laxman
Deficiency of the zinc finger protein ZPR1 causes neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(19):7471-5.
2006: Tachibana Hideo; Perrino Cinzia; Takaoka Hideyuki; Davis Roger J; Naga Prasad Sathyamangla V; Rockman Howard A
JNK1 is required to preserve cardiac function in the early response to pressure overload.
Biochemical and biophysical research communications 2006;343(4):1060-6.
2006: Ventura Juan-Jose; Hübner Anette; Zhang Chao; Flavell Richard A; Shokat Kevan M; Davis Roger J
Chemical genetic analysis of the time course of signal transduction by JNK.
Molecular cell 2006;21(5):701-10.
2005: Gao Yunfei; Tao Jian; Li Ming O; Zhang Dongqing; Chi Hongbo; Henegariu Octavian; Kaech Susan M; Davis Roger J; Flavell Richard A; Yin Zhinan
JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5783-9.
2005: Jaeschke Anja; Rincón Mercedes; Doran Beth; Reilly Judith; Neuberg Donna; Greiner Dale L; Shultz Leonard D; Rossini Aldo A; Flavell Richard A; Davis Roger J
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):6931-5.
2005: Brancho Deborah; Ventura Juan-Jose; Jaeschke Anja; Doran Beth; Flavell Richard A; Davis Roger J
Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades.
Molecular and cellular biology 2005;25(9):3670-81.
2005: Gangwani Laxman; Flavell Richard A; Davis Roger J
ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies.
Molecular and cellular biology 2005;25(7):2744-56.
2005: Kelkar Nyaya; Standen Claire L; Davis Roger J
Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.
Molecular and cellular biology 2005;25(7):2733-43.
2005: Oh Seung Wook; Mukhopadhyay Arnab; Svrzikapa Nenad; Jiang Feng; Davis Roger J; Tissenbaum Heidi A
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4494-9.
2004: Ventura Juan-Jose; Cogswell Patricia; Flavell Richard A; Baldwin Albert S; Davis Roger J
JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species.
Genes & development 2004;18(23):2905-15.
2004: Kuan Chia-Yi; Schloemer Aryn J; Lu Aigang; Burns Kevin A; Weng Wei-Lan; Williams Michael T; Strauss Kenneth I; Vorhees Charles V; Flavell Richard A; Davis Roger J; Sharp Frank R; Rakic Pasko
Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(47):10763-72.
2004: Weston Claire R; Wong Anthony; Hall J Perry; Goad Mary E P; Flavell Richard A; Davis Roger J
The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(39):14114-9.
2004: Jaeschke Anja; Czech Michael P; Davis Roger J
An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue.
Genes & development 2004;18(16):1976-80.
2004: Ventura Juan-Jose; Kennedy Norman J; Flavell Richard A; Davis Roger J
JNK regulates autocrine expression of TGF-beta1.
Molecular cell 2004;15(2):269-78.
2004: Chi Hongbo; Lu Binfeng; Takekawa Mutsuhiro; Davis Roger J; Flavell Richard A
GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells.
The EMBO journal 2004;23(7):1576-86.
2004: Hunot Stéphane; Vila Miquel; Teismann Peter; Davis Roger J; Hirsch Etienne C; Przedborski Serge; Rakic Pasko; Flavell Richard A
JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):665-70.
2003: Kuan Chia-Yi; Whitmarsh Alan J; Yang Derek D; Liao Guanghong; Schloemer Aryn J; Dong Chen; Bao Jue; Banasiak Kenneth J; Haddad Gabriel G; Flavell Richard A; Davis Roger J; Rakic Pasko
A critical role of neural-specific JNK3 for ischemic apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15184-9.
2003: Lee Thomas H; Huang Qiaojia; Oikemus Sarah; Shank Jennifer; Ventura Juan-Jose; Cusson Nicole; Vaillancourt Richard R; Su Bing; Davis Roger J; Kelliher Michelle A
The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase.
Molecular and cellular biology 2003;23(22):8377-85.
2003: Kelkar Nyaya; Delmotte Marie-Helene; Weston Claire R; Barrett Tamera; Sheppard Barbara J; Flavell Richard A; Davis Roger J
Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9843-8.
2003: Brancho Deborah; Tanaka Nobuyuki; Jaeschke Anja; Ventura Juan-Jose; Kelkar Nyaya; Tanaka Yoshinori; Kyuuma Masanao; Takeshita Toshikazu; Flavell Richard A; Davis Roger J
Mechanism of p38 MAP kinase activation in vivo.
Genes & development 2003;17(16):1969-78.
2003: Lamb Jennifer A; Ventura Juan-Jose; Hess Patricia; Flavell Richard A; Davis Roger J
JunD mediates survival signaling by the JNK signal transduction pathway.
Molecular cell 2003;11(6):1479-89.
2003: Zhang Xuchen; Shan Peiying; Alam Jawed; Davis Roger J; Flavell Richard A; Lee Patty J
Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury.
The Journal of biological chemistry 2003;278(24):22061-70.
2003: Weston Claire R; Wong Anthony; Hall J Perry; Goad Mary E P; Flavell Richard A; Davis Roger J
JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure.
Genes & development 2003;17(10):1271-80.
2003: Kennedy Norman J; Davis Roger J
Role of JNK in tumor development.
Cell cycle (Georgetown, Tex.) 2003;2(3):199-201.
2003: Ventura Juan-Jose; Kennedy Norman J; Lamb Jennifer A; Flavell Richard A; Davis Roger J
c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor.
Molecular and cellular biology 2003;23(8):2871-82.
2003: Kennedy Norman J; Sluss Hayla K; Jones Stephen N; Bar-Sagi Dafna; Flavell Richard A; Davis Roger J
Suppression of Ras-stimulated transformation by the JNK signal transduction pathway.
Genes & development 2003;17(5):629-37.
2003: Lei Kui; Davis Roger J
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2432-7.
2003: Zhang Xuchen; Shan Peiying; Otterbein Leo E; Alam Jawed; Flavell Richard A; Davis Roger J; Choi Augustine M K; Lee Patty J
Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3.
The Journal of biological chemistry 2003;278(2):1248-58.
2002: Hess Patricia; Pihan German; Sawyers Charles L; Flavell Richard A; Davis Roger J
Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts.
Nature genetics 2002;32(1):201-5.
2002: Tanaka Nobuyuki; Kamanaka Masahito; Enslen Hervé; Dong Chen; Wysk Mark; Davis Roger J; Flavell Richard A
Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis.
EMBO reports 2002;3(8):785-91.
2002: Diehl Sean; Chow Chi-Wing; Weiss Linda; Palmetshofer Alois; Twardzik Thomas; Rounds Laura; Serfling Edgar; Davis Roger J; Anguita Juan; Rincón Mercedes
Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation.
The Journal of experimental medicine 2002;196(1):39-49.
2002: Lei Kui; Nimnual Anjaruwee; Zong Wei-Xing; Kennedy Norman J; Flavell Richard A; Thompson Craig B; Bar-Sagi Dafna; Davis Roger J
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase.
Molecular and cellular biology 2002;22(13):4929-42.
2002: Weston Claire R; Lambright David G; Davis Roger J
Signal transduction. MAP kinase signaling specificity.
Science (New York, N.Y.) 2002;296(5577):2345-7.
2002: Conze Dietrich; Krahl Troy; Kennedy Norman; Weiss Linda; Lumsden Joanne; Hess Patricia; Flavell Richard A; Le Gros Graham; Davis Roger J; Rincón Mercedes
c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation.
The Journal of experimental medicine 2002;195(7):811-23.
2002: Flavell R A; Dong C; Davis R J
Signaling and cell death in lymphocytes.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51(2):80-2.
2002: Weston Claire R; Davis Roger J
The JNK signal transduction pathway.
Current opinion in genetics & development 2002;12(1):14-21.
2002: Hall J Perry; Davis Roger J
Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell line.
Journal of cellular biochemistry 2002;86(1):1-11.
2002: Hall J Perry; Davis Roger J
Analysis of c-Jun N-terminal kinase regulation and function.
Methods in enzymology 2002;345():413-25.
2001: Whitmarsh A J; Kuan C Y; Kennedy N J; Kelkar N; Haydar T F; Mordes J P; Appel M; Rossini A A; Jones S N; Flavell R A; Rakic P; Davis R J
Requirement of the JIP1 scaffold protein for stress-induced JNK activation.
Genes & development 2001;15(18):2421-32.
2001: Dong C; Davis R J; Flavell R A
Signaling by the JNK group of MAP kinases. c-jun N-terminal Kinase.
Journal of clinical immunology 2001;21(4):253-7.
2001: Miller W E; McDonald P H; Cai S F; Field M E; Davis R J; Lefkowitz R J
Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3.
The Journal of biological chemistry 2001;276(30):27770-7.
2001: Weston C R; Davis R J
Signal transduction: signaling specificity- a complex affair.
Science (New York, N.Y.) 2001;292(5526):2439-40.
2001: Tournier C; Dong C; Turner T K; Jones S N; Flavell R A; Davis R J
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines.
Genes & development 2001;15(11):1419-26.
2001: Lu B; Yu H; Chow C; Li B; Zheng W; Davis R J; Flavell R A
GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells.
Immunity 2001;14(5):583-90.
2001: De Zutter G S; Davis R J
Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6168-73.
2001: Gangwani L; Mikrut M; Theroux S; Sharma M; Davis R J
Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein.
Nature cell biology 2001;3(4):376-83.
2001: Whitmarsh A J; Davis R J
Analyzing JNK and p38 mitogen-activated protein kinase activity.
Methods in enzymology 2001;332():319-36.
2000: Hall J P; Merithew E; Davis R J
c-Jun N-terminal kinase (JNK) repression during the inflammatory response? Just say NO.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14022-4.
2000: McDonald P H; Chow C W; Miller W E; Laporte S A; Field M E; Lin F T; Davis R J; Lefkowitz R J
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
Science (New York, N.Y.) 2000;290(5496):1574-7.
2000: Davis R J
Signal transduction by the JNK group of MAP kinases.
Cell 2000;103(2):239-52.
2000: Constant S L; Dong C; Yang D D; Wysk M; Davis R J; Flavell R A
JNK1 is required for T cell-mediated immunity against Leishmania major infection.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2671-6.
2000: Chow C W; Dong C; Flavell R A; Davis R J
c-Jun NH(2)-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1.
Molecular and cellular biology 2000;20(14):5227-34.
2000: Conze D; Lumsden J; Enslen H; Davis R J; Le Gros G; Rincón M
Activation of p38 MAP kinase in T cells facilitates the immune response to the influenza virus.
Molecular immunology 2000;37(9):503-13.
2000: Li B; Yu H; Zheng W; Voll R; Na S; Roberts A W; Williams D A; Davis R J; Ghosh S; Flavell R A
Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation.
Science (New York, N.Y.) 2000;288(5474):2219-22.
2000: Dong C; Yang D D; Tournier C; Whitmarsh A J; Xu J; Davis R J; Flavell R A
JNK is required for effector T-cell function but not for T-cell activation.
Nature 2000;405(6782):91-4.
2000: Tournier C; Hess P; Yang D D; Xu J; Turner T K; Nimnual A; Bar-Sagi D; Jones S N; Flavell R A; Davis R J
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway.
Science (New York, N.Y.) 2000;288(5467):870-4.
2000: Rincón M; Conze D; Weiss L; Diehl N L; Fortner K A; Yang D; Flavell R A; Enslen H; Whitmarsh A; Davis R J
Conference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways?
Immunology and cell biology 2000;78(2):166-75.
2000: Otterbein L E; Bach F H; Alam J; Soares M; Tao Lu H; Wysk M; Davis R J; Flavell R A; Choi A M
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway.
Nature medicine 2000;6(4):422-8.
2000: Enslen H; Brancho D M; Davis R J
Molecular determinants that mediate selective activation of p38 MAP kinase isoforms.
The EMBO journal 2000;19(6):1301-11.
2000: Kelkar N; Gupta S; Dickens M; Davis R J
Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.
Molecular and cellular biology 2000;20(3):1030-43.
2000: Merritt C; Enslen H; Diehl N; Conze D; Davis R J; Rincón M
Activation of p38 mitogen-activated protein kinase in vivo selectively induces apoptosis of CD8(+) but not CD4(+) T cells.
Molecular and cellular biology 2000;20(3):936-46.
2000: Diehl N L; Enslen H; Fortner K A; Merritt C; Stetson N; Charland C; Flavell R A; Davis R J; Rincón M
Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo.
The Journal of experimental medicine 2000;191(2):321-34.
2000: Weiss L; Whitmarsh A J; Yang D D; Rincón M; Davis R J; Flavell R A
Regulation of c-Jun NH(2)-terminal kinase (Jnk) gene expression during T cell activation.
The Journal of experimental medicine 2000;191(1):139-46.
2000: Chow C W; Davis R J
Integration of calcium and cyclic AMP signaling pathways by 14-3-3.
Molecular and cellular biology 2000;20(2):702-12.
1999: Yasuda J; Whitmarsh A J; Cavanagh J; Sharma M; Davis R J
The JIP group of mitogen-activated protein kinase scaffold proteins.
Molecular and cellular biology 1999;19(10):7245-54.
1999: Shin T H; Yasuda J; Rocheleau C E; Lin R; Soto M; Bei Y; Davis R J; Mello C C
MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans.
Molecular cell 1999;4(2):275-80.
1999: Rocheleau C E; Yasuda J; Shin T H; Lin R; Sawa H; Okano H; Priess J R; Davis R J; Mello C C
WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans.
Cell 1999;97(6):717-26.
1999: Kuan C Y; Yang D D; Samanta Roy D R; Davis R J; Rakic P; Flavell R A
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.
Neuron 1999;22(4):667-76.
1999: Lu H T; Yang D D; Wysk M; Gatti E; Mellman I; Davis R J; Flavell R A
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice.
The EMBO journal 1999;18(7):1845-57.
1999: Wysk M; Yang D D; Lu H T; Flavell R A; Davis R J
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3763-8.
1999: Chow C W; Rincón M; Davis R J
Requirement for transcription factor NFAT in interleukin-2 expression.
Molecular and cellular biology 1999;19(3):2300-7.
1999: Tournier C; Whitmarsh A J; Cavanagh J; Barrett T; Davis R J
The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases.
Molecular and cellular biology 1999;19(2):1569-81.
1999: Li B; Tournier C; Davis R J; Flavell R A
Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation.
The EMBO journal 1999;18(2):420-32.
1999: Flavell R A; Li B; Dong C; Lu H T; Yang D D; Enslen H; Tournier C; Whitmarsh A; Wysk M; Conze D; Rincon M; Davis R J
Molecular basis of T-cell differentiation.
Cold Spring Harbor symposia on quantitative biology 1999;64():563-71.
1998: Gangwani L; Mikrut M; Galcheva-Gargova Z; Davis R J
Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells.
The Journal of cell biology 1998;143(6):1471-84.
1998: Dong C; Yang D D; Wysk M; Whitmarsh A J; Davis R J; Flavell R A
Defective T cell differentiation in the absence of Jnk1.
Science (New York, N.Y.) 1998;282(5396):2092-5.
1998: Rincón M; Whitmarsh A; Yang D D; Weiss L; Dérijard B; Jayaraj P; Davis R J; Flavell R A
The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes.
The Journal of experimental medicine 1998;188(10):1817-30.
1998: Yang D D; Conze D; Whitmarsh A J; Barrett T; Davis R J; Rincón M; Flavell R A
Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.
Immunity 1998;9(4):575-85.
1998: Galcheva-Gargova Z; Gangwani L; Konstantinov K N; Mikrut M; Theroux S J; Enoch T; Davis R J
The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells.
Molecular biology of the cell 1998;9(10):2963-71.
1998: Flavell R A; Rincón M; Zheng W P; Li B; Enslen H; Raingeaud J; Davis R J
The regulation of CD4 T cell differentiation.
European cytokine network 1998;9(3 Suppl):26-32.
1998: Whitmarsh A J; Cavanagh J; Tournier C; Yasuda J; Davis R J
A mammalian scaffold complex that selectively mediates MAP kinase activation.
Science (New York, N.Y.) 1998;281(5383):1671-4.
1998: Han Z S; Enslen H; Hu X; Meng X; Wu I H; Barrett T; Davis R J; Ip Y T
A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression.
Molecular and cellular biology 1998;18(6):3527-39.
1998: Rincón M; Enslen H; Raingeaud J; Recht M; Zapton T; Su M S; Penix L A; Davis R J; Flavell R A
Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway.
The EMBO journal 1998;17(10):2817-29.
1998: Jacqué J M; Mann A; Enslen H; Sharova N; Brichacek B; Davis R J; Stevenson M
Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase.
The EMBO journal 1998;17(9):2607-18.
1998: Ip Y T; Davis R J
Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development.
Current opinion in cell biology 1998;10(2):205-19.
1998: Elbirt K K; Whitmarsh A J; Davis R J; Bonkovsky H L
Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinases.
The Journal of biological chemistry 1998;273(15):8922-31.
1998: Enslen H; Raingeaud J; Davis R J
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.
The Journal of biological chemistry 1998;273(3):1741-8.
1997: Chow C W; Rincón M; Cavanagh J; Dickens M; Davis R J
Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway.
Science (New York, N.Y.) 1997;278(5343):1638-41.
1997: Yang D D; Kuan C Y; Whitmarsh A J; Rincón M; Zheng T S; Davis R J; Rakic P; Flavell R A
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene.
Nature 1997;389(6653):865-70.
1997: Sluss H K; Davis R J
Embryonic morphogenesis signaling pathway mediated by JNK targets the transcription factor JUN and the TGF-beta homologue decapentaplegic.
Journal of cellular biochemistry 1997;67(1):1-12.
1997: Dickens M; Rogers J S; Cavanagh J; Raitano A; Xia Z; Halpern J R; Greenberg M E; Sawyers C L; Davis R J
A cytoplasmic inhibitor of the JNK signal transduction pathway.
Science (New York, N.Y.) 1997;277(5326):693-6.
1997: Tournier C; Whitmarsh A J; Cavanagh J; Barrett T; Davis R J
Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7337-42.
1997: Whitmarsh A J; Yang S H; Su M S; Sharrocks A D; Davis R J
Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors.
Molecular and cellular biology 1997;17(5):2360-71.
1997: Yang D; Tournier C; Wysk M; Lu H T; Xu J; Davis R J; Flavell R A
Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3004-9.
1997: Rincón M; Dérijard B; Chow C W; Davis R J; Flavell R A
Reprogramming the signalling requirement for AP-1 (activator protein-1) activation during differentiation of precursor CD4+ T-cells into effector Th1 and Th2 cells.
Genes and function 1997;1(1):51-68.
1996: Taglienti C A; Wysk M; Davis R J
Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE.
Oncogene 1996;13(12):2563-74.
1996: Sluss H K; Han Z; Barrett T; Goberdhan D C; Wilson C; Davis R J; Ip Y T
A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.
Genes & development 1996;10(21):2745-58.
1996: Whitmarsh A J; Davis R J
Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways.
Journal of molecular medicine (Berlin, Germany) 1996;74(10):589-607.
1996: Shore P; Whitmarsh A J; Bhaskaran R; Davis R J; Waltho J P; Sharrocks A D
Determinants of DNA-binding specificity of ETS-domain transcription factors.
Molecular and cellular biology 1996;16(7):3338-49.
1996: Gupta S; Barrett T; Whitmarsh A J; Cavanagh J; Sluss H K; Dérijard B; Davis R J
Selective interaction of JNK protein kinase isoforms with transcription factors.
The EMBO journal 1996;15(11):2760-70.
1996: Galcheva-Gargova Z; Konstantinov K N; Wu I H; Klier F G; Barrett T; Davis R J
Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor.
Science (New York, N.Y.) 1996;272(5269):1797-802.
1996: Raingeaud J; Whitmarsh A J; Barrett T; Dérijard B; Davis R J
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
Molecular and cellular biology 1996;16(3):1247-55.
1996: Shapiro P S; Evans J N; Davis R J; Posada J A
The seven-transmembrane-spanning receptors for endothelin and thrombin cause proliferation of airway smooth muscle cells and activation of the extracellular regulated kinase and c-Jun NH2-terminal kinase groups of mitogen-activated protein kinases.
The Journal of biological chemistry 1996;271(10):5750-4.
1995: Galcheva-Gargova Z; Theroux S J; Davis R J
The epidermal growth factor receptor is covalently linked to ubiquitin.
Oncogene 1995;11(12):2649-55.
1995: Xia Z; Dickens M; Raingeaud J; Davis R J; Greenberg M E
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis.
Science (New York, N.Y.) 1995;270(5240):1326-31.
1995: Whitmarsh A J; Shore P; Sharrocks A D; Davis R J
Integration of MAP kinase signal transduction pathways at the serum response element.
Science (New York, N.Y.) 1995;269(5222):403-7.
1995: Raingeaud J; Gupta S; Rogers J S; Dickens M; Han J; Ulevitch R J; Davis R J
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine.
The Journal of biological chemistry 1995;270(13):7420-6.
1995: Wartmann M; Campbell D; Subramanian A; Burstein S H; Davis R J
The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide.
FEBS letters 1995;359(2-3):133-6.
1995: Dérijard B; Raingeaud J; Barrett T; Wu I H; Han J; Ulevitch R J; Davis R J
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.
Science (New York, N.Y.) 1995;267(5198):682-5.
1995: Gupta S; Campbell D; Dérijard B; Davis R J
Transcription factor ATF2 regulation by the JNK signal transduction pathway.
Science (New York, N.Y.) 1995;267(5196):389-93.
1994: Minden A; Lin A; McMahon M; Lange-Carter C; Dérijard B; Davis R J; Johnson G L; Karin M
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK.
Science (New York, N.Y.) 1994;266(5191):1719-23.
1994: Sluss H K; Barrett T; Dérijard B; Davis R J
Signal transduction by tumor necrosis factor mediated by JNK protein kinases.
Molecular and cellular biology 1994;14(12):8376-84.
1994: Davis R J
MAPKs: new JNK expands the group.
Trends in biochemical sciences 1994;19(11):470-3.
1994: Gupta S; Davis R J
MAP kinase binds to the NH2-terminal activation domain of c-Myc.
FEBS letters 1994;353(3):281-5.
1994: Galcheva-Gargova Z; Dérijard B; Wu I H; Davis R J
An osmosensing signal transduction pathway in mammalian cells.
Science (New York, N.Y.) 1994;265(5173):806-8.
1994: Dérijard B; Hibi M; Wu I H; Barrett T; Su B; Deng T; Karin M; Davis R J
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.
Cell 1994;76(6):1025-37.
1994: Wartmann M; Davis R J
The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex.
The Journal of biological chemistry 1994;269(9):6695-701.
1994: Li L; Wysk M; Gonzalez F A; Davis R J
Genomic loci of human mitogen-activated protein kinases.
Oncogene 1994;9(2):647-9.
1993: Gonzalez F A; Seth A; Raden D L; Bowman D S; Fay F S; Davis R J
Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus.
The Journal of cell biology 1993;122(5):1089-101.
1993: Davis R J
The mitogen-activated protein kinase signal transduction pathway.
The Journal of biological chemistry 1993;268(20):14553-6.
1993: Seth A; Gupta S; Davis R J
Cell cycle regulation of the c-Myc transcriptional activation domain.
Molecular and cellular biology 1993;13(7):4125-36.
1993: Gupta S; Seth A; Davis R J
Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3216-20.
1993: Taglienti-Sian C A; Banner B; Davis R J; Robinson H L
Induction of renal adenocarcinoma by a nonmutated erbB oncogene.
Journal of virology 1993;67(2):1132-6.
1993: Selva E; Raden D L; Davis R J
Mitogen-activated protein kinase stimulation by a tyrosine kinase-negative epidermal growth factor receptor.
The Journal of biological chemistry 1993;268(3):2250-4.
1993: Davis R J
Sphingolipid regulation of the epidermal growth factor receptor.
Advances in lipid research 1993;25():131-45.
1992: Seth A; Gonzalez F A; Gupta S; Raden D L; Davis R J
Signal transduction within the nucleus by mitogen-activated protein kinase.
The Journal of biological chemistry 1992;267(34):24796-804.
1992: Theroux S J; Stanley K; Campbell D A; Davis R J
Mutational removal of the major site of serine phosphorylation of the epidermal growth factor receptor causes potentiation of signal transduction: role of receptor down-regulation.
Molecular endocrinology (Baltimore, Md.) 1992;6(11):1849-57.
1992: Theroux S J; Latour D A; Stanley K; Raden D L; Davis R J
Signal transduction by the epidermal growth factor receptor is attenuated by a COOH-terminal domain serine phosphorylation site.
The Journal of biological chemistry 1992;267(23):16620-6.
1992: Gonzalez F A; Raden D L; Rigby M R; Davis R J
Heterogeneous expression of four MAP kinase isoforms in human tissues.
FEBS letters 1992;304(2-3):170-8.
1992: Nair N; Davis R J; Robinson H L
Protein tyrosine kinase activities of the epidermal growth factor receptor and ErbB proteins: correlation of oncogenic activation with altered kinetics.
Molecular and cellular biology 1992;12(5):2010-6.
1992: Theroux S J; Taglienti-Sian C; Nair N; Countaway J L; Robinson H L; Davis R J
Increased oncogenic potential of ErbB is associated with the loss of a COOH-terminal domain serine phosphorylation site.
The Journal of biological chemistry 1992;267(12):7967-70.
1992: Theroux S J; Davis R J
Rapid screening of cloned DNA fragments for specific mutations.
Nucleic acids research 1992;20(4):915.
1992: Countaway J L; Nairn A C; Davis R J
Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.
The Journal of biological chemistry 1992;267(2):1129-40.
1991: Seth A; Alvarez E; Gupta S; Davis R J
A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression.
The Journal of biological chemistry 1991;266(35):23521-4.
1991: Gonzalez F A; Raden D L; Davis R J
Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.
The Journal of biological chemistry 1991;266(33):22159-63.
1991: Gironès N; Alverez E; Seth A; Lin I M; Latour D A; Davis R J
Mutational analysis of the cytoplasmic tail of the human transferrin receptor. Identification of a sub-domain that is required for rapid endocytosis.
The Journal of biological chemistry 1991;266(28):19006-12.
1991: Alvarez E; Northwood I C; Gonzalez F A; Latour D A; Seth A; Abate C; Curran T; Davis R J
Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase.
The Journal of biological chemistry 1991;266(23):15277-85.
1991: Northwood I C; Gonzalez F A; Wartmann M; Raden D L; Davis R J
Isolation and characterization of two growth factor-stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669.
The Journal of biological chemistry 1991;266(23):15266-76.
1991: Bowen S; Stanley K; Selva E; Davis R J
Constitutive phosphorylation of the epidermal growth factor receptor blocks mitogenic signal transduction.
The Journal of biological chemistry 1991;266(2):1162-9.
1990: Alvarez E; Gironès N; Davis R J
Inhibition of the receptor-mediated endocytosis of diferric transferrin is associated with the covalent modification of the transferrin receptor with palmitic acid.
The Journal of biological chemistry 1990;265(27):16644-55.
1990: Northwood I C; Davis R J
Signal transduction by the epidermal growth factor receptor after functional desensitization of the receptor tyrosine protein kinase activity.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6107-11.
1990: Weis F M; Davis R J
Regulation of epidermal growth factor receptor signal transduction. Role of gangliosides.
The Journal of biological chemistry 1990;265(20):12059-66.
1990: Alvarez E; Gironès N; Davis R J
A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis.
The Biochemical journal 1990;267(1):31-5.
1990: Countaway J L; McQuilkin P; Gironès N; Davis R J
Multisite phosphorylation of the epidermal growth factor receptor. Use of site-directed mutagenesis to examine the role of serine/threonine phosphorylation.
The Journal of biological chemistry 1990;265(6):3407-16.
1989: Gironès N; Davis R J
Comparison of the kinetics of cycling of the transferrin receptor in the presence or absence of bound diferric transferrin.
The Biochemical journal 1989;264(1):35-46.
1989: Countaway J L; Gironès N; Davis R J
Reconstitution of epidermal growth factor receptor transmodulation by platelet-derived growth factor in Chinese hamster ovary cells.
The Journal of biological chemistry 1989;264(23):13642-7.
1989: Alvarez E; Gironès N; Davis R J
Intermolecular disulfide bonds are not required for the expression of the dimeric state and functional activity of the transferrin receptor.
The EMBO journal 1989;8(8):2231-40.
1989: Countaway J L; Northwood I C; Davis R J
Mechanism of phosphorylation of the epidermal growth factor receptor at threonine 669.
The Journal of biological chemistry 1989;264(18):10828-35.
1989: Northwood I C; Davis R J
Protein kinase C inhibition of the epidermal growth factor receptor tyrosine protein kinase activity is independent of the oligomeric state of the receptor.
The Journal of biological chemistry 1989;264(10):5746-50.
1988: Davis R J
Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity.
The Journal of biological chemistry 1988;263(19):9462-9.
1988: Northwood I C; Davis R J
Activation of the epidermal growth factor receptor tyrosine protein kinase in the absence of receptor oligomerization.
The Journal of biological chemistry 1988;263(16):7450-3.
1988: Davis R J; Gironès N; Faucher M
Two alternative mechanisms control the interconversion of functional states of the epidermal growth factor receptor.
The Journal of biological chemistry 1988;263(11):5373-9.
1988: Faucher M; Gironès N; Hannun Y A; Bell R M; Davis R J
Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells.
The Journal of biological chemistry 1988;263(11):5319-27.
1987: Davis R J; Meisner H
Regulation of transferrin receptor cycling by protein kinase C is independent of receptor phosphorylation at serine 24 in Swiss 3T3 fibroblasts.
The Journal of biological chemistry 1987;262(33):16041-7.
1987: Davis R J; Faucher M; Racaniello L K; Carruthers A; Czech M P
Insulin-like growth factor I and epidermal growth factor regulate the expression of transferrin receptors at the cell surface by distinct mechanisms.
The Journal of biological chemistry 1987;262(27):13126-34.
1987: Davis R J; Czech M P
Regulatory control of the epidermal growth factor receptor tyrosine kinase.
Haematology and blood transfusion 1987;31():228-32.

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