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Thomas Davis

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Patrick T Ronaldson; Thomas P Davis
Targeted drug delivery to treat pain and cerebral hypoxia.
Gwen McCaffrey; Thomas P Davis
Physiology and pathophysiology of the blood-brain barrier: P-glycoprotein and occludin trafficking as therapeutic targets to optimize central nervous system drug delivery.
Gwen McCaffrey; Patrick Ronaldson; Lucy Sanchez-Covarrubias; William D Staatz; Kristen Demarco; Jessica D Finch; Mei-Li Laracuente; Thomas P Davis
P-glycoprotein trafficking at the blood-brain barrier altered by peripheral inflammatory hyperalgesia.

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All Publications

2013: Patrick T Ronaldson; Thomas P Davis
Targeted drug delivery to treat pain and cerebral hypoxia.
Pharmacological reviews 2013;65(1):291-314.
2012: Gwen McCaffrey; Thomas P Davis
Physiology and pathophysiology of the blood-brain barrier: P-glycoprotein and occludin trafficking as therapeutic targets to optimize central nervous system drug delivery.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2012;60(8):1131-40.
2012: Gwen McCaffrey; Patrick Ronaldson; Lucy Sanchez-Covarrubias; William D Staatz; Kristen Demarco; Jessica D Finch; Mei-Li Laracuente; Thomas P Davis
P-glycoprotein trafficking at the blood-brain barrier altered by peripheral inflammatory hyperalgesia.
Journal of neurochemistry 2012;122(5):962-75.
2012: Patricia D Williams; Berislav V Zlokovic; John H Griffin; Kent E Pryor; Thomas P Davis
Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke.
Current pharmaceutical design 2012;18(27):4215-22.
2012: Patrick T Ronaldson; Thomas P Davis
Blood-brain barrier integrity and glial support: mechanisms that can be targeted for novel therapeutic approaches in stroke.
Current pharmaceutical design 2012;18(25):3624-44.
2011: Patrick T Ronaldson; Thomas P Davis
Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery.
Therapeutic delivery 2011;2(8):1015-41.
2011: Patrick Ronaldson; Jessica D Finch; Kristin M Demarco; Colleen E Quigley; Thomas P Davis
Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 2011;336(3):827-39.
2010: Colin L Willis; Diana S Meske; Thomas P Davis
Protein kinase C activation modulates reversible increase in cortical blood-brain barrier permeability and tight junction protein expression during hypoxia and posthypoxic reoxygenation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(11):1847-59.
2010: Jeffrey J Lochhead; Gwen McCaffrey; Colleen E Quigley; Jessica Finch; Kristin M DeMarco; Nicole Nametz; Thomas P Davis
Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(9):1625-36.
2009: Gwen McCaffrey; Colin L Willis; William D Staatz; Nicole Nametz; Carolyn A Quigley; Sharon Hom; Jeffrey J Lochhead; Thomas P Davis
Occludin oligomeric assemblies at tight junctions of the blood-brain barrier are altered by hypoxia and reoxygenation stress.
Journal of neurochemistry 2009;110(1):58-71.
2009: Patrick Ronaldson; Kristin M Demarco; Lucy Sanchez-Covarrubias; Christine M Solinsky; Thomas P Davis
Transforming growth factor-beta signaling alters substrate permeability and tight junction protein expression at the blood-brain barrier during inflammatory pain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(6):1084-98.
2008: Gwen McCaffrey; Melissa J Seelbach; William D Staatz; Nicole Nametz; Carolyn Quigley; Christopher R Campos; Tracy A Brooks; Thomas P Davis
Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia.
Journal of neurochemistry 2008;106(6):2395-409.
2008: Christopher R Campos; Scott M Ocheltree; Sharon Hom; Richard D Egleton; Thomas P Davis
Nociceptive inhibition prevents inflammatory pain induced changes in the blood-brain barrier.
Brain research 2008;1221():6-13.
2008: Tracy A Brooks; Nicole Nametz; Rachael Charles; Thomas P Davis
Diclofenac attenuates the regional effect of lambda-carrageenan on blood-brain barrier function and cytoarchitecture.
The Journal of pharmacology and experimental therapeutics 2008;325(2):665-73.
2008: C L Willis; T A Brooks; Thomas P Davis
Chronic inflammatory pain and the neurovascular unit: a central role for glia in maintaining BBB integrity?
Current pharmaceutical design 2008;14(16):1625-43.
2008: Ken A Witt; Karen S Mark; Karin E Sandoval; Thomas P Davis
Reoxygenation stress on blood-brain barrier paracellular permeability and edema in the rat.
Microvascular research 2008;75(1):91-6.
2007: Gwen McCaffrey; William D Staatz; Carolyn A Quigley; Nicole Nametz; Melissa J Seelbach; Christopher R Campos; Tracy A Brooks; Richard D Egleton; Thomas P Davis
Tight junctions contain oligomeric protein assembly critical for maintaining blood-brain barrier integrity in vivo.
Journal of neurochemistry 2007;103(6):2540-55.
2007: Melissa J Seelbach; Tracy A Brooks; Richard D Egleton; Thomas P Davis
Peripheral inflammatory hyperalgesia modulates morphine delivery to the brain: a role for P-glycoprotein.
Journal of neurochemistry 2007;102(5):1677-90.
2007: Sharon Hom; Melissa A Fleegal; Richard D Egleton; Christopher R Campos; Brian Hawkins; Thomas P Davis
Comparative changes in the blood-brain barrier and cerebral infarction of SHR and WKY rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;292(5):R1881-92.
2006: Tracy A Brooks; Scott M Ocheltree; Melissa J Seelbach; Rachael A Charles; Nicole Nametz; Richard D Egleton; Thomas P Davis
Biphasic cytoarchitecture and functional changes in the BBB induced by chronic inflammatory pain.
Brain research 2006;1120(1):172-82.
2006: Jason D Huber; Christopher R Campos; Karen S Mark; Thomas P Davis
Alterations in blood-brain barrier ICAM-1 expression and brain microglial activation after lambda-carrageenan-induced inflammatory pain.
American journal of physiology. Heart and circulatory physiology 2006;290(2):H732-40.
2006: Ken A Witt; Thomas P Davis
CNS drug delivery: opioid peptides and the blood-brain barrier.
The AAPS journal 2006;8(1):E76-88.
2005: Melissa A Fleegal; Sharon Hom; Lindsay K Borg; Thomas P Davis
Activation of PKC modulates blood-brain barrier endothelial cell permeability changes induced by hypoxia and posthypoxic reoxygenation.
American journal of physiology. Heart and circulatory physiology 2005;289(5):H2012-9.
2005: Tracy A Brooks; Brian Hawkins; Jason D Huber; Richard D Egleton; Thomas P Davis
Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations.
American journal of physiology. Heart and circulatory physiology 2005;289(2):H738-43.
2005: Brian Hawkins; Richard D Egleton; Thomas P Davis
Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors.
American journal of physiology. Heart and circulatory physiology 2005;289(1):H212-9.
2005: Brian Hawkins; Thomas P Davis
The blood-brain barrier/neurovascular unit in health and disease.
Pharmacological reviews 2005;57(2):173-85.
2005: Richard D Egleton; Thomas P Davis
Development of neuropeptide drugs that cross the blood-brain barrier.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2005;2(1):44-53.
2005: Ken A Witt; Karen S Mark; Jason Huber; Thomas P Davis
Hypoxia-inducible factor and nuclear factor kappa-B activation in blood-brain barrier endothelium under hypoxic/reoxygenation stress.
Journal of neurochemistry 2005;92(1):203-14.
2004: Brian Hawkins; Thomas J Abbruscato; Richard D Egleton; Rachel C Brown; Jason D Huber; Christopher R Campos; Thomas P Davis
Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution.
Brain research 2004;1027(1-2):48-58.
2004: Vincent S Hau; Jason D Huber; Christopher R Campos; Ryan T Davis; Thomas P Davis
Effect of lambda-carrageenan-induced inflammatory pain on brain uptake of codeine and antinociception.
Brain research 2004;1018(2):257-64.
2004: Rachel C Brown; Richard D Egleton; Thomas P Davis
Mannitol opening of the blood-brain barrier: regional variation in the permeability of sucrose, but not 86Rb+ or albumin.
Brain research 2004;1014(1-2):221-7.
2004: Rachel C Brown; Karen S Mark; Richard D Egleton; Thomas P Davis
Protection against hypoxia-induced blood-brain barrier disruption: changes in intracellular calcium.
American journal of physiology. Cell physiology 2004;286(5):C1045-52.
2004: Karen S Mark; Amanda R Burroughs; Rachel C Brown; Jason D Huber; Thomas P Davis
Nitric oxide mediates hypoxia-induced changes in paracellular permeability of cerebral microvasculature.
American journal of physiology. Heart and circulatory physiology 2004;286(1):H174-80.
2003: Ken A Witt; Karen S Mark; Sharon Hom; Thomas P Davis
Effects of hypoxia-reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression.
American journal of physiology. Heart and circulatory physiology 2003;285(6):H2820-31.
2003: Anne M Wolka; Jason D Huber; Thomas P Davis
Pain and the blood-brain barrier: obstacles to drug delivery.
Advanced drug delivery reviews 2003;55(8):987-1006.
2003: Jason D Huber; Christopher R Campos; Richard D Egleton; Ken A Witt; Lihong Guo; Michael J Roberts; Michael D Bentley; Thomas P Davis
Conjugation of low molecular weight poly(ethylene glycol) to biphalin enhances antinociceptive profile.
Journal of pharmaceutical sciences 2003;92(7):1377-85.
2003: Richard D Egleton; Christopher C Campos; Jason D Huber; Rachel C Brown; Thomas P Davis
Differential effects of diabetes on rat choroid plexus ion transporter expression.
Diabetes 2003;52(6):1496-501.
2003: Rachel C Brown; Karen S Mark; Richard D Egleton; Jason D Huber; Amanda R Burroughs; Thomas P Davis
Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.
Journal of cell science 2003;116(Pt 4):693-700.
2002: Thomas J Abbruscato; Steve P Lopez; Karen S Mark; Brian Hawkins; Thomas P Davis
Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells.
Journal of pharmaceutical sciences 2002;91(12):2525-38.
2002: Ken A Witt; Jason D Huber; Richard D Egleton; Thomas P Davis
Pluronic p85 block copolymer enhances opioid peptide analgesia.
The Journal of pharmacology and experimental therapeutics 2002;303(2):760-7.
2002: Jason D Huber; Vincent S Hau; L Borg; Christopher R Campos; Richard D Egleton; Thomas P Davis
Blood-brain barrier tight junctions are altered during a 72-h exposure to lambda-carrageenan-induced inflammatory pain.
American journal of physiology. Heart and circulatory physiology 2002;283(4):H1531-7.
2002: Vincent S Hau; Jason D Huber; Christopher R Campos; Andrzej W Lipkowski; Aleksandra Misicka; Thomas P Davis
Effect of guanidino modification and proline substitution on the in vitro stability and blood-brain barrier permeability of endomorphin II.
Journal of pharmaceutical sciences 2002;91(10):2140-9.
2002: Jason D Huber; Vincent S Hau; Karen S Mark; Rachel C Brown; Christopher R Campos; Thomas P Davis
Viability of microvascular endothelial cells to direct exposure of formalin, lambda-carrageenan, and complete Freund's adjuvant.
European journal of pharmacology 2002;450(3):297-304.
2002: Rachel C Brown; Thomas P Davis
Calcium modulation of adherens and tight junction function: a potential mechanism for blood-brain barrier disruption after stroke.
Stroke; a journal of cerebral circulation 2002;33(6):1706-11.
2002: Karen S Mark; Thomas P Davis
Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation.
American journal of physiology. Heart and circulatory physiology 2002;282(4):H1485-94.
2002: Brian Hawkins; Rachel C Brown; Thomas P Davis
Smoking and ischemic stroke: a role for nicotine?
Trends in pharmacological sciences 2002;23(2):78-82.
2001: Ken A Witt; TJ Gillespie; Jason D Huber; Richard D Egleton; Thomas P Davis
Peptide drug modifications to enhance bioavailability and blood-brain barrier permeability.
Peptides 2001;22(12):2329-43.
2001: Jason D Huber; Richard D Egleton; Thomas P Davis
Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier.
Trends in neurosciences 2001;24(12):719-25.
2001: Richard D Egleton; SA Mitchell; Jason D Huber; Michael M Palian; Robin Polt; Thomas P Davis
Improved blood-brain barrier penetration and enhanced analgesia of an opioid peptide by glycosylation.
The Journal of pharmacology and experimental therapeutics 2001;299(3):967-72.
2001: Ken A Witt; Jason D Huber; Richard D Egleton; Michael J Roberts; Michael D Bentley; L Guo; H Wei; Henry I Yamamura; Thomas P Davis
Pharmacodynamic and pharmacokinetic characterization of poly(ethylene glycol) conjugation to met-enkephalin analog [D-Pen2, D-Pen5]-enkephalin (DPDPE).
The Journal of pharmacology and experimental therapeutics 2001;298(2):848-56.
2001: Jason D Huber; Ken A Witt; Sharon Hom; Richard D Egleton; Karen S Mark; Thomas P Davis
Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression.
American journal of physiology. Heart and circulatory physiology 2001;280(3):H1241-8.
2001: Sharon Hom; Richard D Egleton; Jason D Huber; Thomas P Davis
Effect of reduced flow on blood-brain barrier transport systems.
Brain research 2001;890(1):38-48.
2000: Karen S Mark; Thomas P Davis
Stroke: development, prevention and treatment with peptidase inhibitors.
Peptides 2000;21(12):1965-73.
2000: Ken A Witt; Jason D Huber; Richard D Egleton; Thomas P Davis
Insulin enhancement of opioid peptide transport across the blood-brain barrier and assessment of analgesic effect.
The Journal of pharmacology and experimental therapeutics 2000;295(3):972-8.
2000: Richard D Egleton; SA Mitchell; Jason D Huber; J Janders; Dagmar Stropova; Robin Polt; Henry I Yamamura; Victor J Hruby; Thomas P Davis
Improved bioavailability to the brain of glycosylated Met-enkephalin analogs.
Brain research 2000;881(1):37-46.
2000: Matthew P Rounseville; Thomas P Davis
Prohormone convertase and autocrine growth factor mRNAs are coexpressed in small cell lung carcinoma.
Journal of molecular endocrinology 2000;25(1):121-8.
2000: Ken A Witt; CA Slate; Richard D Egleton; Jason D Huber; Henry I Yamamura; Victor J Hruby; Thomas P Davis
Assessment of stereoselectivity of trimethylphenylalanine analogues of delta-opioid [D-Pen(2),D-Pen(5)]-enkephalin.
Journal of neurochemistry 2000;75(1):424-35.
2000: Edward J Bilsky; Richard D Egleton; SA Mitchell; Michael M Palian; Peg Davis; Jason D Huber; H Jones; Henry I Yamamura; J Janders; Thomas P Davis; Frank Porreca; Victor J Hruby; Robin Polt
Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability.
Journal of medicinal chemistry 2000;43(13):2586-90.
2000: R Newcomb; Thomas J Abbruscato; T Singh; L Nadasdi; Thomas P Davis; GP Miljanich
Bioavailability of Ziconotide in brain: influx from blood, stability, and diffusion.
Peptides 2000;21(4):491-501.
1999: Thomas J Abbruscato; Thomas P Davis
Protein expression of brain endothelial cell E-cadherin after hypoxia/aglycemia: influence of astrocyte contact.
Brain research 1999;842(2):277-86.
1999: Thomas J Abbruscato; Thomas P Davis
Combination of hypoxia/aglycemia compromises in vitro blood-brain barrier integrity.
The Journal of pharmacology and experimental therapeutics 1999;289(2):668-75.
1999: Richard D Egleton; Thomas P Davis
Transport of the delta-opioid receptor agonist [D-penicillamine2,5] enkephalin across the blood-brain barrier involves transcytosis1.
Journal of pharmaceutical sciences 1999;88(4):392-7.
1999: C L Gentry; Richard D Egleton; TJ Gillespie; Thomas J Abbruscato; H B Bechowski; Victor J Hruby; Thomas P Davis
The effect of halogenation on blood-brain barrier permeability of a novel peptide drug.
Peptides 1999;20(10):1229-38.
1998: Richard D Egleton; Thomas J Abbruscato; SA Thomas; Thomas P Davis
Transport of opioid peptides into the central nervous system.
Journal of pharmaceutical sciences 1998;87(11):1433-9.
1998: TJ Gillespie; A Erenberg; S Kim; J Dong; J E Taylor; Vincent S Hau; Thomas P Davis
Novel somatostatin analogs for the treatment of acromegaly and cancer exhibit improved in vivo stability and distribution.
The Journal of pharmacology and experimental therapeutics 1998;285(1):95-104.
1998: G Li; W Haq; L Xiang; B S Lou; R Hughes; I A De Leon; Peg Davis; TJ Gillespie; Marek Romanowski; Xiaoyun Zhu; Aleksandra Misicka; Andrzej W Lipkowski; Frank Porreca; Thomas P Davis; Henry I Yamamura; David F O'Brien; Victor J Hruby
Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide.
Bioorganic & medicinal chemistry letters 1998;8(5):555-60.
1998: J Slaninova; Suzanne M Appleyard; Aleksandra Misicka; Andrzej W Lipkowski; Richard J Knapp; S J Weber; Thomas P Davis; Henry I Yamamura; Victor J Hruby
[125I-Tyr1]biphalin binding to opioid receptors of rat brain and NG108-15 cell membranes.
Life sciences 1998;62(14):PL199-204.
1997: Thomas J Abbruscato; SA Thomas; Victor J Hruby; Thomas P Davis
Brain and spinal cord distribution of biphalin: correlation with opioid receptor density and mechanism of CNS entry.
Journal of neurochemistry 1997;69(3):1236-45.
1997: SA Thomas; Thomas J Abbruscato; Vincent S Hau; TJ Gillespie; J Zsigo; Victor J Hruby; Thomas P Davis
Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability.
The Journal of pharmacology and experimental therapeutics 1997;281(2):817-25.
1997: S M Waters; Thomas P Davis
Alterations of peptide metabolism and neuropeptidase activity in senile dementia of the Alzheimer's type.
Annals of the New York Academy of Sciences 1997;814():30-9.
1997: S M Waters; Matthew P Rounseville; Thomas P Davis
Effect of dopaminergic drugs on processing and degradative neuropeptidase mRNA in rat frontal cortex and caudate-putamen.
Brain research 1997;754(1-2):28-34.
1997: SA Thomas; Thomas J Abbruscato; Victor J Hruby; Thomas P Davis
The entry of [D-penicillamine2,5]enkephalin into the central nervous system: saturation kinetics and specificity.
The Journal of pharmacology and experimental therapeutics 1997;280(3):1235-40.
1997: Richard D Egleton; Thomas P Davis
Bioavailability and transport of peptides and peptide drugs into the brain.
Peptides 1997;18(9):1431-9.
1997: Iris R Bell; Gary E Schwartz; Richard R Bootzin; Vincent S Hau; Thomas P Davis
Elevation of plasma beta-endorphin levels of shy elderly in response to novel laboratory experiences.
Behavioral medicine (Washington, D.C.) 1997;22(4):168-73.
1997: Thomas J Abbruscato; SA Thomas; Victor J Hruby; Thomas P Davis
Blood-brain barrier permeability and bioavailability of a highly potent and mu-selective opioid receptor antagonist, CTAP: comparison with morphine.
The Journal of pharmacology and experimental therapeutics 1997;280(1):402-9.
1996: C S Konkoy; Thomas P Davis
Ectoenzymes as sites of peptide regulation.
Trends in pharmacological sciences 1996;17(8):288-94.
1996: Iris R Bell; Richard R Bootzin; Thomas P Davis; Vincent S Hau; Cheryl Ritenbaugh; K A Johnson; Gary E Schwartz
Time-dependent sensitization of plasma beta-endorphin in community elderly with self-reported environmental chemical odor intolerance.
Biological psychiatry 1996;40(2):134-43.
1996: D L Greene; Vincent S Hau; Thomas J Abbruscato; H Bartosz; Aleksandra Misicka; Andrzej W Lipkowski; S Hom; TJ Gillespie; Victor J Hruby; Thomas P Davis
Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability.
The Journal of pharmacology and experimental therapeutics 1996;277(3):1366-75.
1996: S M Waters; C S Konkoy; Thomas P Davis
Haloperidol and apomorphine differentially affect neuropeptidase activity.
The Journal of pharmacology and experimental therapeutics 1996;277(1):113-20.
1996: B Mania-Farnell; Thomas P Davis
Modulation of prohormone convertase mRNA by second messenger activators and drugs.
Annals of the New York Academy of Sciences 1996;780():134-44.
1996: Thomas J Abbruscato; S A Williams; Aleksandra Misicka; Andrzej W Lipkowski; Victor J Hruby; Thomas P Davis
Blood-to-central nervous system entry and stability of biphalin, a unique double-enkephalin analog, and its halogenated derivatives.
The Journal of pharmacology and experimental therapeutics 1996;276(3):1049-57.
1996: S A Williams; Thomas J Abbruscato; Victor J Hruby; Thomas P Davis
Passage of a delta-opioid receptor selective enkephalin, [D-penicillamine2,5] enkephalin, across the blood-brain and the blood-cerebrospinal fluid barriers.
Journal of neurochemistry 1996;66(3):1289-99.
1996: C S Konkoy; S M Waters; Thomas P Davis
Subchronic haloperidol administration decreases aminopeptidase N activity and [Met5]enkephalin metabolism in rat striatum and cortex.
European journal of pharmacology 1996;297(1-2):47-51.
1996: B L Mania-Farnell; I Botros; R Day; Thomas P Davis
Differential modulation of prohormone convertase mRNA by second messenger activators in two cholecystokinin-producing cell lines.
Peptides 1996;17(1):47-54.
1995: C S Konkoy; Thomas P Davis
Regional metabolism of Met-enkephalin and cholecystokinin on intact ratbrain slices: characterization of specific peptidases.
Journal of neurochemistry 1995;65(6):2773-82.
1995: J A Schetz; C A Mayr; J E Taylor; M Rosenblatt; M Chorev; Thomas P Davis
Distribution and pharmacokinetics of a potent peptide antagonist of parathyroid hormone and parathyroid hormone-related protein in the rat.
The Journal of pharmacology and experimental therapeutics 1995;274(3):1456-62.
1995: S M Waters; C S Konkoy; Thomas P Davis
Neuropeptide metabolism on intact, regional brain slices: effect of dopaminergic agents on substance P, cholecystokinin and Met-enkephalin degradation.
The Journal of pharmacology and experimental therapeutics 1995;274(2):783-9.
1995: Thomas P Davis; Thomas J Abbruscato; E Brownson; Victor J Hruby
Conformationally constrained peptide drugs targeted at the blood-brain barrier.
NIDA research monograph 1995;154():47-60.
1995: J P Meyer; TJ Gillespie; S Hom; Victor J Hruby; Thomas P Davis
In vitro stability of some reduced peptide bond pseudopeptide analogues of dynorphin A.
Peptides 1995;16(7):1215-9.
1995: J Slaninova; Richard J Knapp; S J Weber; Thomas P Davis; S N Fang; Victor J Hruby; Henry I Yamamura
[125I]SNF 8702: a selective radioligand for CCKB receptors.
Peptides 1995;16(2):221-4.
1994: E A Brownson; Thomas J Abbruscato; TJ Gillespie; Victor J Hruby; Thomas P Davis
Effect of peptidases at the blood brain barrier on the permeability of enkephalin.
The Journal of pharmacology and experimental therapeutics 1994;270(2):675-80.
1994: Robin Polt; F Porreca; L Z Szabò; E J Bilsky; P Davis; Thomas J Abbruscato; Thomas P Davis; R Harvath; Henry I Yamamura; Victor J Hruby
Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7114-8.
1994: M G Oakes; Thomas P Davis
The ontogeny of enzymes involved in post-translational processing and metabolism of neuropeptides.
Brain research. Developmental brain research 1994;80(1-2):127-36.
1994: R C Haaseth; P J Horan; E J Bilsky; P Davis; T Zalewska; J Slaninova; Henry I Yamamura; S J Weber; Thomas P Davis; F Porreca
[L-Ala3]DPDPE: a new enkephalin analog with a unique opioid receptor activity profile. Further evidence of delta-opioid receptor multiplicity.
Journal of medicinal chemistry 1994;37(11):1572-7.
1994: C S Konkoy; S M Waters; Thomas P Davis
Acute administration of neuroleptics decreases neurotensin metabolism on intact, regional rat brain slices.
The Journal of pharmacology and experimental therapeutics 1994;269(2):555-63.
1994: B L Mania-Farnell; Bradley J. Merrill; Henry I Yamamura; Thomas P Davis
Second messenger activators regulate CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC.
Annals of the New York Academy of Sciences 1994;713():446-8.
1993: B L Mania-Farnell; Bradley J. Merrill; P N Konings; Thomas P Davis
Regulation of CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC in response to second messenger activators.
FEBS letters 1993;335(1):65-8.
1993: RK Rao; Otakar Koldovsky; Thomas P Davis
Fate of intraduodenally administered somatostatin in rats in vivo.
Peptides 1993;14(6):1199-203.
1993: S J Weber; Thomas J Abbruscato; E A Brownson; Andrzej W Lipkowski; Robin Polt; Aleksandra Misicka; R C Haaseth; H Bartosz; Victor J Hruby; Thomas P Davis
Assessment of an in vitro blood-brain barrier model using several [Met5]enkephalin opioid analogs.
The Journal of pharmacology and experimental therapeutics 1993;266(3):1649-55.
1993: C S Konkoy; M G Oakes; Thomas P Davis
Chronic treatment with neuroleptics alters neutral endopeptidase 24.11 activity in rat brain regions.
Peptides 1993;14(5):1017-20.
1993: D A Clark; R Day; N Seidah; Terry W Moody; F Cuttitta; Thomas P Davis
Protease inhibitors suppress in vitro growth of human small cell lung cancer.
Peptides 1993;14(5):1021-8.
1993: RK Rao; H H Chang; S Levenson; F Porreca; P M Brannon; Thomas P Davis; Otakar Koldovsky
Ontogenic differences in the inhibition of gastric acid secretion by epidermal growth factor.
The Journal of pharmacology and experimental therapeutics 1993;266(2):647-54.
1993: P N Konings; B Mania-Farnell; M C Beinfeld; M G Oakes; R Day; N G Seidah; Thomas P Davis
Processing, release and metabolism of cholecystokinin in SK-N-MCIXC cells.
Neuropeptides 1993;25(1):19-30.
1993: P J Horan; A Mattia; E J Bilsky; S Weber; Thomas P Davis; Henry I Yamamura; Ewa Malatynska; Suzanne M Appleyard; J Slaninova; Aleksandra Misicka
Antinociceptive profile of biphalin, a dimeric enkephalin analog.
The Journal of pharmacology and experimental therapeutics 1993;265(3):1446-54.
1993: P J Horan; K D Wild; Aleksandra Misicka; Andrzej W Lipkowski; R C Haaseth; Victor J Hruby; S J Weber; Thomas P Davis; Henry I Yamamura; F Porreca
Agonist and antagonist profiles of [D-Ala2,Glu4]deltorphin and its [Cys4]- and [Ser4]-substituted derivatives: further evidence of opioid delta receptor multiplicity.
The Journal of pharmacology and experimental therapeutics 1993;265(2):896-902.
1993: P J Horan; K D Wild; W M Kazmierski; R Ferguson; Victor J Hruby; S J Weber; Thomas P Davis; L Fang; Richard J Knapp; Henry I Yamamura
Unexpected antinociceptive potency of cyclic [D-Tca1]CTAP: potential for a novel mechanism of action.
European journal of pharmacology 1993;233(1):53-62.
1993: Thomas P Davis; P N Konings
Peptidases in the CNS: formation of biologically active, receptor-specific peptide fragments.
Critical reviews in neurobiology 1993;7(3-4):163-74.
1992: S J Weber; D L Greene; Victor J Hruby; Henry I Yamamura; F Porreca; Thomas P Davis
Whole body and brain distribution of [3H]cyclic [D-Pen2,D-Pen5] enkephalin after intraperitoneal, intravenous, oral and subcutaneous administration.
The Journal of pharmacology and experimental therapeutics 1992;263(3):1308-16.
1992: Thomas P Davis; S Crowell; J Taylor; D L Clark; D Coy; J Staley; Terry W Moody
Metabolic stability and tumor inhibition of bombesin/GRP receptor antagonists.
Peptides 1992;13(2):401-7.
1992: Thomas P Davis; TJ Gillespie; P N Konings
Specificity of neurotensin metabolism by regional rat brain slices.
Journal of neurochemistry 1992;58(2):608-17.
1992: TJ Gillespie; P N Konings; Bradley J. Merrill; Thomas P Davis
A specific enzyme assay for aminopeptidase M in rat brain.
Life sciences 1992;51(26):2097-106.
1992: S J Weber; R B Louis; L Trombley; Garth Bissette; Peter Davies; Thomas P Davis
Metabolic half-life of somatostatin and peptidase activities are altered in Alzheimer's disease.
Journal of gerontology 1992;47(1):B18-25.
1991: S J Weber; D L Greene; S D Sharma; Henry I Yamamura; T H Kramer; T F Burks; Victor J Hruby; Louis B Hersh; Thomas P Davis
Distribution and analgesia of [3H][D-Pen2, D-Pen5]enkephalin and two halogenated analogs after intravenous administration.
The Journal of pharmacology and experimental therapeutics 1991;259(3):1109-17.
1991: RK Rao; O Koldovský; J Grimes; C Williams; Thomas P Davis
Regional differences in gastrointestinal processing and absorption of epidermal growth factor in suckling rats.
The American journal of physiology 1991;261(5 Pt 1):G790-8.
1991: Richard J Knapp; S D Sharma; G Toth; M T Duong; L Fang; C L Bogert; S J Weber; M Hunt; Thomas P Davis; J K Wamsley
[D-Pen2,4'-125I-Phe4,D-Pen5]enkephalin: a selective high affinity radioligand for delta opioid receptors with exceptional specific activity.
The Journal of pharmacology and experimental therapeutics 1991;258(3):1077-83.
1991: Thomas P Davis; TJ Gillespie; J Shook; T H Kramer; G Hoyer; K Hawkins; P Davis; Henry I Yamamura; T F Burks
Changes in opioid receptor selectivity following processing of peptide E: effect on gut motility.
Gastroenterology 1991;100(6):1603-15.
1991: Thomas P Davis; S Crowell; B McInturff; R Louis; TJ Gillespie
Neurotensin may function as a regulatory peptide in small cell lung cancer.
Peptides 1991;12(1):17-23.
1990: Thomas P Davis; G L Hoyer; P Davis; T F Burks
Proenkephalin A-derived peptide E and its fragments alter opioid contractility in the small intestine.
European journal of pharmacology 1990;191(3):253-61.
1990: P N Konings; A Culling-Berglund; Thomas P Davis
Chronic haloperidol and chlorpromazine treatment alters in vitro beta-endorphin metabolism in rat brain.
European journal of pharmacology 1990;191(2):115-28.
1990: RK Rao; O Koldovský; M Korc; P F Pollack; S Wright; Thomas P Davis
Processing and transfer of epidermal growth factor in developing rat jejunum and ileum.
Peptides 1990;11(6):1093-102.
1990: Z W Li; W A Bijl; J W van Nispen; Klaus Brendel; Thomas P Davis
Neuropeptide processing in regional brain slices: effect of conformation and sequence.
The Journal of pharmacology and experimental therapeutics 1990;253(2):851-7.
1990: S A Newcomb; A J Culling-Berglund; Thomas P Davis
Endogenous levels of beta-carotene in human buccal mucosa cells by reversed-phase high-performance liquid chromatography.
Journal of chromatography 1990;526(1):47-58.
1990: RK Rao; Otakar Koldovsky; Thomas P Davis
Inhibition of intestinal degradation of somatostatin by rat milk.
The American journal of physiology 1990;258(3 Pt 1):G426-31.
1989: J Staley; Gary Fiskum; Thomas P Davis; Terry W Moody
Neurotensin elevates cytosolic calcium in small cell lung cancer cells.
Peptides 1989;10(6):1217-21.
1989: Thomas P Davis; TJ Gillespie; F Porreca
Peptide fragments derived from the beta-chain of hemoglobin (hemorphins) are centrally active in vivo.
Peptides 1989;10(4):747-51.
1989: Thomas P Davis; H S Burgess; S Crowell; Terry W Moody; A Culling-Berglund; R H Liu
Beta-endorphin and neurotensin stimulate in vitro clonal growth of human SCLC cells.
European journal of pharmacology 1989;161(2-3):283-5.
1989: S L Crowell; H S Burgess; Thomas P Davis
The effect of mycoplasma on the autocrine stimulation of human small cell lung cancer in vitro by bombesin and beta-endorphin.
Life sciences 1989;45(25):2471-6.
1988: Z W Li; Klaus Brendel; A J Culling-Berglund; Thomas P Davis
Regional specificity of beta-endorphin metabolism in brain slices of the rat.
Proceedings of the Western Pharmacology Society 1988;31():67-70.
1987: Thomas P Davis; A J Culling-Berglund; TJ Gillespie; T L Smith
Ethanol treatment alters beta-endorphin metabolism by purified synaptosomal plasma membranes.
Peptides 1987;8(3):467-72.
1987: Thomas P Davis; A Culling-Berglund
Neuroleptic drug treatment alters in vitro central neurotensin metabolism.
Psychoneuroendocrinology 1987;12(4):253-60.
1987: Thomas P Davis; J E Shook; TJ Gillespie; A J Culling-Berglund; H M Papietro; F Porreca
The proenkephalin A fragment peptide E is metabolized centrally to a novel peptide with opioid activity.
Proceedings of the Western Pharmacology Society 1987;30():321-5.