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Marcia Dawson

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Lulu Farhana; Jayanta K Das; Marcia I Dawson; Farhan Murshed; Arun K Rishi; Joseph A Fontana
Upregulation of miR-150* and miR-630 Induces Apoptosis in Pancreatic Cancer Cells by Targeting IGF-1R.
Alice Kiselyuk; Seung-Hee Lee; Sonalee Athavankar; Paul Bushway; Yong Cang; John Cashman; Tom Cohen; Marcia I Dawson; Suzette Farber-Katz; Hudson Freeze; Jennifer Higginbotham; Heather A Hostetler; Li Huang; Pamela Itkin-Ansari; Mark Mercola; Anthony B Pinkerton; Adam D Richardson; Mariam Rodriguez-Lee; Friedhelm Schroeder; Layton Smith; Benjamin Spangler; Mao Ye; Mingjun Zhang; Fred Levine
HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.
Lulu Farhana; Jayanta K Das; Marcia I Dawson; Timothy J Hadden; James Hatfield; Farhan Murshed; Zebin Xia; Joseph A Fontana
Adamantyl Retinoid-Related Molecules Induce Apoptosis in Pancreatic Cancer Cells by Inhibiting IGF-1R and Wnt/β-Catenin Pathways.

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All Publications

2013: Lulu Farhana; Jayanta K Das; Marcia I Dawson; Farhan Murshed; Arun K Rishi; Joseph A Fontana
Upregulation of miR-150* and miR-630 Induces Apoptosis in Pancreatic Cancer Cells by Targeting IGF-1R.
PloS one 2013;8(5):e61015.
2012: Alice Kiselyuk; Seung-Hee Lee; Sonalee Athavankar; Paul Bushway; Yong Cang; John Cashman; Tom Cohen; Marcia I Dawson; Suzette Farber-Katz; Hudson Freeze; Jennifer Higginbotham; Heather A Hostetler; Li Huang; Pamela Itkin-Ansari; Mark Mercola; Anthony B Pinkerton; Adam D Richardson; Mariam Rodriguez-Lee; Friedhelm Schroeder; Layton Smith; Benjamin Spangler; Mao Ye; Mingjun Zhang; Fred Levine
HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.
Chemistry & biology 2012;19(7):806-18.
2012: Lulu Farhana; Jayanta K Das; Marcia I Dawson; Timothy J Hadden; James Hatfield; Farhan Murshed; Zebin Xia; Joseph A Fontana
Adamantyl Retinoid-Related Molecules Induce Apoptosis in Pancreatic Cancer Cells by Inhibiting IGF-1R and Wnt/β-Catenin Pathways.
Journal of oncology 2012;2012():796729.
2011: Zebin Xia; Lulu Farhana; Ricardo G Correa; Jayanta K Das; David J Castro; Jinghua Yu; Robert Glen Oshima; John C Reed; Joseph A Fontana; Marcia I Dawson
Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid.
Journal of medicinal chemistry 2011;54(11):3793-816.
2010: Lulu Farhana; Marcia I Dawson; Zebin Xia; Amro Aboukameel; Liping Xu; Gang Liu; Jayanta K Das; James Hatfield; Edi Levi; Ramzi M Mohammad; Joseph A Fontana
Adamantyl-substituted retinoid-related molecules induce apoptosis in human acute myelogenous leukemia cells.
Molecular cancer therapeutics 2010;9(11):2903-13.
2010: Liyue Zhang; Anil Wali; Joseph A Fontana; Marcia I Dawson; Arun K Rishi
Novel cis-trans interactions are involved in post-transcriptional regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 mRNA.
Journal of molecular signaling 2010;5():12.
2009: Marcia I Dawson; Mao Ye; Xihua Cao; Lulu Farhana; Qiong-Ying Hu; Yong Zhao; Li Ping Xu; Alice Kiselyuk; Ricardo G Correa; Li Yang; Tingjun Hou; John C Reed; Pamela Itkin-Ansari; Fred Levine; Michel F Sanner; Joseph A Fontana; Xiao-kun Zhang
Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene.
ChemMedChem 2009;4(7):1106-19.
2009: Lulu Farhana; Marcia I Dawson; Jan-Hermen Dannenberg; Liping Xu; Joseph A Fontana
SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule-mediated nuclear factor-kappaB activation, c-Fos/c-Jun expression, and cellular apoptosis.
Molecular cancer therapeutics 2009;8(6):1625-35.
2008: Marcia I Dawson; Zebin Xia; Tao Jiang; Mao Ye; Joseph A Fontana; Lulu Farhana; Bhaumik B Patel; Li Ping Xue; Mohammad Bhuiyan; Roberto Pellicciari; Antonio Macchiarulo; Roberto Nuti; Xiao-kun Zhang; Young-Hoon Han; Lutz Tautz; Peter D Hobbs; Ling Jong; Nahid Waleh; Wan-Ru Chao; Gen-Sheng Feng; Yuhong Pang; Ying Su
Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.
Journal of medicinal chemistry 2008;51(18):5650-62.
2008: Matthew H Cato; Federica D'Annibale; David M Mills; Fabio Cerignoli; Marcia I Dawson; Enrico Bergamaschi; Nunzio Bottini; Andrea Magrini; Antonio Bergamaschi; Nicola Rosato; Robert C Rickert; Tomas Mustelin; Massimo Bottini
Cell-type specific and cytoplasmic targeting of PEGylated carbon nanotube-based nanoassemblies.
Journal of nanoscience and nanotechnology 2008;8(5):2259-69.
2007: Marcia I Dawson; Zebin Xia; Gang Liu; Mao Ye; Joseph A Fontana; Lulu Farhana; Bhaumik B Patel; Sankari Arumugarajah; Mohammad Bhuiyan; Xiao-kun Zhang; Young-Hoon Han; William B Stallcup; Jun-ichi Fukushi; Tomas Mustelin; Lutz Tautz; Ying Su; Danni L Harris; Nahid Waleh; Peter D Hobbs; Ling Jong; Wan-Ru Chao; Leonard J Schiff; Brahma P Sani
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Journal of medicinal chemistry 2007;50(11):2622-39.
2007: Massimo Bottini; Federica D'Annibale; Andrea Magrini; Fabio Cerignoli; Yutaka Arimura; Marcia I Dawson; Enrico Bergamaschi; Nicola Rosato; Antonio Bergamaschi; Tomas Mustelin
Quantum dot-doped silica nanoparticles as probes for targeting of T-lymphocytes.
International journal of nanomedicine 2007;2(2):227-33.
2007: Lulu Farhana; Marcia I Dawson; Mark Leid; Li Wang; David D Moore; Gang Liu; Zeben Xia; Joseph A Fontana
Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor.
Cancer research 2007;67(1):318-25.
2006: Xuguang Yan; Max L Deinzer; Michael I Schimerlik; David Broderick; Mark Leid; Marcia I Dawson
Investigation of ligand interactions with human RXRalpha by hydrogen/deuterium exchange and mass spectrometry.
Journal of the American Society for Mass Spectrometry 2006;17(11):1510-7.
2006: Massimo Bottini; Fabio Cerignoli; Marcia I Dawson; Andrea Magrini; Nicola Rosato; Tomas Mustelin
Full-length single-walled carbon nanotubes decorated with streptavidin-conjugated quantum dots as multivalent intracellular fluorescent nanoprobes.
Biomacromolecules 2006;7(8):2259-63.
2006: Young-Hoon Han; X Cao; B Lin; F Lin; Siva Kumar Kolluri; John L Stebbins; J C Reed; Marcia I Dawson; Xiao-kun Zhang
Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.
Oncogene 2006;25(21):2974-86.
2006: Massimo Bottini; Andrea Magrini; Almerinda Di Venere; Stefano Bellucci; Marcia I Dawson; Nicola Rosato; Antonio Bergamaschi; Tomas Mustelin
Synthesis and characterization of supramolecular nanostructures of carbon nanotubes and ruthenium-complex Luminophores.
Journal of nanoscience and nanotechnology 2006;6(5):1381-6.
2006: Massimo Bottini; Chidambara Balasubramanian; Marcia I Dawson; Antonio Bergamaschi; Stefano Bellucci; Tomas Mustelin
Isolation and characterization of fluorescent nanoparticles from pristine and oxidized electric arc-produced single-walled carbon nanotubes.
The journal of physical chemistry. B 2006;110(2):831-6.
2005: Lulu Farhana; Marcia I Dawson; Joseph A Fontana
Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation.
Cancer research 2005;65(11):4909-17.
2005: Massimo Bottini; Lutz Tautz; Huong Huynh; Edward Monosov; Nunzio Bottini; Marcia I Dawson; Stefano Bellucci; Tomas Mustelin
Covalent decoration of multi-walled carbon nanotubes with silica nanoparticles.
Chemical communications (Cambridge, England) 2005;(6):758-60.
2004: Xihua Cao; Wen Liu; Feng Lin; Hui Li; Siva Kumar Kolluri; Bingzhen Lin; Young-Hoon Han; Marcia I Dawson; Xiao-kun Zhang
Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting.
Molecular and cellular biology 2004;24(22):9705-25.
2004: Claudio N Cavasotto; Gang Liu; Sharon Y James; Peter D Hobbs; Valerie J Peterson; Ananyo A Bhattacharya; Siva Kumar Kolluri; Xiao-kun Zhang; Mark Leid; Ruben Abagyan; Robert C Liddington; Marcia I Dawson
Determinants of retinoid X receptor transcriptional antagonism.
Journal of medicinal chemistry 2004;47(18):4360-72.
2004: Marcia I Dawson; Danni L Harris; Gang Liu; Peter D Hobbs; Christopher W Lange; Ling Jong; Nathalie Bruey-Sedano; Sharon Y James; Xiao-kun Zhang; Valerie J Peterson; Mark Leid; Lulu Farhana; Arun K Rishi; Joseph A Fontana
Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest.
Journal of medicinal chemistry 2004;47(14):3518-36.
2004: Marcia I Dawson
Synthetic retinoids and their nuclear receptors.
Current medicinal chemistry. Anti-cancer agents 2004;4(3):199-230.
2004: Lulu Farhana; Marcia I Dawson; Ying Huang; Yuxiang Zhang; Arun K Rishi; Kaladhar B Reddy; Robert S Freeman; Joseph A Fontana
Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities.
Oncogene 2004;23(10):1874-84.
2004: Bingzhen Lin; Siva Kumar Kolluri; Feng Lin; Wen Liu; Young-Hoon Han; Xihua Cao; Marcia I Dawson; John C Reed; Xiao-kun Zhang
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3.
Cell 2004;116(4):527-40.
2003: Siva Kumar Kolluri; Nathalie Bruey-Sedano; Xihua Cao; Bingzhen Lin; Feng Lin; Young-Hoon Han; Marcia I Dawson; Xiao-kun Zhang
Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells.
Molecular and cellular biology 2003;23(23):8651-67.
2003: Yuxiang Zhang; Marcia I Dawson; Yangmin Ning; Lisa Anne Polin ; Ralph E Parchment; Thomas H Corbett; Anwar N Mohamed; Kai-Chia Feng; Lulu Farhana; Arun K Rishi; Donna Hogge; Mark Leid; Valerie J Peterson; Xiao-kun Zhang; Ramzi M Mohammad; Jin-Song Lu; Cheryl L Willman; Eric VanBuren; Sandra Biggar; Mark Edelstein; David Eilender; Joseph A Fontana
Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog.
Blood 2003;102(10):3743-52.
2003: Arun K Rishi; Liyue Zhang; Madanamohan Boyanapalli; Anil Wali; Ramzi M Mohammad; Yingjie Yu; Joseph A Fontana; James S Hatfield; Marcia I Dawson; Adhip N Majumdar; Uwe Reichert
Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437.
The Journal of biological chemistry 2003;278(35):33422-35.
2003: Sharon Y James; Feng Lin; Siva Kumar Kolluri; Marcia I Dawson; Xiao-kun Zhang
Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells.
Cancer research 2003;63(13):3531-8.
2002: Yuxiang Zhang; Marcia I Dawson; Ramzi M Mohammad; Arun K Rishi; Lulu Farhana; Kai-Chia Feng; Mark Leid; Valerie J Peterson; Xiao-kun Zhang; Mark Edelstein; David Eilander; Sandra Biggar; Nathan Wall; Uwe Reichert; Joseph A Fontana
Induction of apoptosis of human B-CLL and ALL cells by a novel retinoid and its nonretinoidal analog.
Blood 2002;100(8):2917-25.
2002: Guo-quan Chen; Bingzhen Lin; Marcia I Dawson; Xiao-kun Zhang
Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells.
International journal of cancer. Journal international du cancer 2002;99(2):171-8.
2002: Marcia I Dawson; Xiao-kun Zhang
Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid.
Current medicinal chemistry 2002;9(6):623-37.
2002: Valerie J Peterson; Elisabeth Barofsky; Max L Deinzer; Marcia I Dawson; Kai-Chia Feng; Xiao-kun Zhang; Machender R Madduru; Mark Leid
Mass-spectrometric analysis of agonist-induced retinoic acid receptor gamma conformational change.
The Biochemical journal 2002;362(Pt 1):173-81.
2001: Marcia I Dawson; Peter D Hobbs; Valerie J Peterson; Mark Leid; C W Lange; Kai-Chia Feng; J Gu; H Li; Siva Kumar Kolluri; Y Zhang; Joseph A Fontana
Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity.
Cancer research 2001;61(12):4723-30.
2001: Marcia I Dawson; J H Park; G Chen; W Chao; Linda Dousman; Nahid Waleh; Peter D Hobbs; Ling Jong; Lawrence Toll; X Zhang; J Gu; A Agadir; Juanita L Merchant; Longchuan Bai; A K Verma; SM Thacher; Roshantha A S Chandraratna; B Shroot; D L Hill
Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition.
International journal of cancer. Journal international du cancer 2001;91(1):8-21.
2000: H Li; Siva Kumar Kolluri; J Gu; Marcia I Dawson; Xihua Cao; Peter D Hobbs; Bingzhen Lin; G Chen; J Lu; Feng Lin; Z Xie; Joseph A Fontana; John C Reed; X Zhang
Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.
Science (New York, N.Y.) 2000;289(5482):1159-64.
2000: Marcia I Dawson; Ling Jong; Peter D Hobbs; D Xiao; Kai-Chia Feng; Wan-Ru Chao; C Pan; Joseph A Fontana; Xiao-kun Zhang
4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists.
Bioorganic & medicinal chemistry letters 2000;10(12):1311-3.
2000: Marcia I Dawson; Peter D Hobbs; Ling Jong; D Xiao; Wan-Ru Chao; C Pan; Xiao-kun Zhang
sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity.
Bioorganic & medicinal chemistry letters 2000;10(12):1307-10.
2000: DJ Nevrivy; Valerie J Peterson; Dorina Avram; Jane E Ishmael; Scott G Hansen; P Dowell; Dennis E Hruby; Marcia I Dawson; Mark Leid
Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors.
The Journal of biological chemistry 2000;275(22):16827-36.
2000: Joseph A Fontana; Marcia I Dawson; Mark Leid; Arun K Rishi; Yuxiang Zhang; C A Hsu; Jin-Song Lu; Valerie J Peterson; Ling Jong; Peter D Hobbs; Wan-Ru Chao; B Shroot; Uwe Reichert
Identification of a unique binding protein specific for a novel retinoid inducing cellular apoptosis.
International journal of cancer. Journal international du cancer 2000;86(4):474-9.
2000: Shi-Yong Sun; Ping Yue; Li Mao; Marcia I Dawson; B Shroot; William W Lamph; Richard A Heyman; Roshantha A S Chandraratna; K Shudo; Waun Ki Hong; Reuben Lotan
Identification of receptor-selective retinoids that are potent inhibitors of the growth of human head and neck squamous cell carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1563-73.
2000: Yuxiang Zhang; Arun K Rishi; Marcia I Dawson; R Tschang; Lulu Farhana; Madanamohan Boyanapalli; Uwe Reichert; B Shroot; Eric Van Buren; Joseph A Fontana
S-phase arrest and apoptosis induced in normal mammary epithelial cells by a novel retinoid.
Cancer research 2000;60(7):2025-32.
1999: Arun K Rishi; RJ Sun; Y Gao; CK Hsu; TM Gerald; MS Sheikh; Marcia I Dawson; Uwe Reichert; B Shroot; A J Fornace; G Brewer; Joseph A Fontana
Post-transcriptional regulation of the DNA damage-inducible gadd45 gene in human breast carcinoma cells exposed to a novel retinoid CD437.
Nucleic acids research 1999;27(15):3111-9.
1999: Michael I Schimerlik; Valerie J Peterson; Peter D Hobbs; Marcia I Dawson; Mark Leid
Kinetic and thermodynamic analysis of 9-cis-retinoic acid binding to retinoid X receptor alpha.
Biochemistry 1999;38(21):6732-40.
1999: Masaaki Shiohara; Marcia I Dawson; Peter D Hobbs; N Sawai; T Higuchi; Kenichi Koike; Atsushi Komiyama; H Phillip Koeffler
Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro.
Blood 1999;93(6):2057-66.
1999: JY Liang; Joseph A Fontana; Rao Jaladanki; J V Ordonez; Marcia I Dawson; B Shroot; JF Wilber; Pei Feng
Synthetic retinoid CD437 induces S-phase arrest and apoptosis in human prostate cancer cells LNCaP and PC-3.
The Prostate 1999;38(3):228-36.
1999: Shi-Yong Sun; Jonathan M Kurie; Ping Yue; Marcia I Dawson; B Shroot; Roshantha A S Chandraratna; Waun Ki Hong; Reuben Lotan
Differential responses of normal, premalignant, and malignant human bronchial epithelial cells to receptor-selective retinoids.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(2):431-7.
1999: MJ Campbell; S Park; Milan Uskokovic; Marcia I Dawson; Ling Jong; H Phillip Koeffler
Synergistic inhibition of prostate cancer cell lines by a 19-nor hexafluoride vitamin D3 analogue and anti-activator protein 1 retinoid.
British journal of cancer 1999;79(1):101-7.
1998: Marcia I Dawson; Wan-Ru Chao; Peter D Hobbs; Xiao-kun Zhang
Effects of trans-retinoic acid, 9-cis-retinoic acid, 1alpha,25-(dihydroxy)vitamin D3 and a novel apoptosis-inducing retinoid on breast cancer and endothelial cell growth.
Cancer letters 1998;133(1):1-8.
1998: H Wan; Marcia I Dawson; Waun Ki Hong; Reuben Lotan
Overexpressed activated retinoid X receptors can mediate growth inhibitory effects of retinoids in human carcinoma cells.
The Journal of biological chemistry 1998;273(41):26915-22.
1998: Y Li; Bingzhen Lin; A Agadir; R Liu; Marcia I Dawson; John C Reed; Joseph A Fontana; Frédéric Bost; Peter D Hobbs; Y Zheng; Guo-quan Chen; B Shroot; Dan Mercola; Xiao-kun Zhang
Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines.
Molecular and cellular biology 1998;18(8):4719-31.
1998: MJ Campbell; S Park; Milan Uskokovic; Marcia I Dawson; H Phillip Koeffler
Expression of retinoic acid receptor-beta sensitizes prostate cancer cells to growth inhibition mediated by combinations of retinoids and a 19-nor hexafluoride vitamin D3 analog.
Endocrinology 1998;139(4):1972-80.
1998: Ho-Young Lee; Garrett L Walsh; Marcia I Dawson; Waun Ki Hong; Jonathan M Kurie
All-trans-retinoic acid inhibits Jun N-terminal kinase-dependent signaling pathways.
The Journal of biological chemistry 1998;273(12):7066-71.
1998: Ho-Young Lee; D F Dohi; Y H Kim; G L Walsh; U Consoli; Michael Andreeff; Marcia I Dawson; Waun Ki Hong; Jonathan M Kurie
All-trans retinoic acid converts E2F into a transcriptional suppressor and inhibits the growth of normal human bronchial epithelial cells through a retinoic acid receptor- dependent signaling pathway.
The Journal of clinical investigation 1998;101(5):1012-9.
1998: Y Li; Marcia I Dawson; A Agadir; M O Lee; Ling Jong; Peter D Hobbs; Xiao-kun Zhang
Regulation of RAR beta expression by RAR- and RXR-selective retinoids in human lung cancer cell lines: effect on growth inhibition and apoptosis induction.
International journal of cancer. Journal international du cancer 1998;75(1):88-95.
1998: Joseph A Fontana; RJ Sun; Arun K Rishi; Marcia I Dawson; J V Ordónez; Yuxiang Zhang; S H Tschang; Kapil N Bhalla; Z Han; James H Wyche; GC Poirer; MS Sheikh; B Shroot; Uwe Reichert
Overexpression of bcl-2 or bcl-XL fails to inhibit apoptosis mediated by a novel retinoid.
Oncology research 1998;10(6):313-24.
1997: Shi-Yong Sun; Ping Yue; Marcia I Dawson; B Shroot; S Michel; William W Lamph; Richard A Heyman; M Teng; Roshantha A S Chandraratna; K Shudo; Waun Ki Hong; Reuben Lotan
Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells.
Cancer research 1997;57(21):4931-9.
1997: Q Wu; Marcia I Dawson; Y Zheng; Peter D Hobbs; A Agadir; Ling Jong; Y Li; R Liu; Bingzhen Lin; Xiao-kun Zhang
Inhibition of trans-retinoic acid-resistant human breast cancer cell growth by retinoid X receptor-selective retinoids.
Molecular and cellular biology 1997;17(11):6598-608.
1997: H Wan; Marcia I Dawson; Waun Ki Hong; Reuben Lotan
Enhancement of Calu-1 human lung carcinoma cell growth in serum-free medium by retinoids: dependence on AP-1 activation, but not on retinoid response element activation.
Oncogene 1997;15(17):2109-18.
1997: C A Hsu; Arun K Rishi; X Su-Li; TM Gerald; Marcia I Dawson; Charles Alan Schiffer; Uwe Reichert; B Shroot; GC Poirer; Joseph A Fontana
Retinoid induced apoptosis in leukemia cells through a retinoic acid nuclear receptor-independent pathway.
Blood 1997;89(12):4470-9.
1997: Wan-Ru Chao; Peter D Hobbs; Ling Jong; Xiao-kun Zhang; Y Zheng; Q Wu; B Shroot; Marcia I Dawson
Effects of receptor class- and subtype-selective retinoids and an apoptosis-inducing retinoid on the adherent growth of the NIH:OVCAR-3 ovarian cancer cell line in culture.
Cancer letters 1997;115(1):1-7.
1997: CK Hsu; Arun K Rishi; X S Li; Marcia I Dawson; Uwe Reichert; B Shroot; Joseph A Fontana
Bcl-X(L) expression and its downregulation by a novel retinoid in breast carcinoma cells.
Experimental cell research 1997;232(1):17-24.
1997: Ho-Young Lee; Marcia I Dawson; Francois Claret; J D Chen; Garrett L Walsh; Waun Ki Hong; Jonathan M Kurie
Evidence of a retinoid signaling alteration involving the activator protein 1 complex in tumorigenic human bronchial epithelial cells and non-small cell lung cancer cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(3):283-91.
1996: Arun K Rishi; T M Gerald; Zhi-min Shao; X S Li; R G Baumann; Marcia I Dawson; Joseph A Fontana
Regulation of the human retinoic acid receptor alpha gene in the estrogen receptor negative human breast carcinoma cell lines SKBR-3 and MDA-MB-435.
Cancer research 1996;56(22):5246-52.
1996: X S Li; Arun K Rishi; Zhi-min Shao; Marcia I Dawson; Ling Jong; B Shroot; Uwe Reichert; J Ordonez; Joseph A Fontana
Posttranscriptional regulation of p21WAF1/CIP1 expression in human breast carcinoma cells.
Cancer research 1996;56(21):5055-62.
1996: Ho-Young Lee; Marcia I Dawson; Garrett L Walsh; Jonathan C Nesbitt; Richard L Eckert; E Fuchs; Waun Ki Hong; Reuben Lotan; Jonathan M Kurie
Retinoic acid receptor- and retinoid X receptor-selective retinoids activate signaling pathways that converge on AP-1 and inhibit squamous differentiation in human bronchial epithelial cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(8):997-1004.
1996: N La Vista-Picard; Peter D Hobbs; Magnus Pfahl; Marcia I Dawson; M Pfahl
The receptor-DNA complex determines the retinoid response: a mechanism for the diversification of the ligand signal.
Molecular and cellular biology 1996;16(8):4137-46.
1996: M O Lee; Marcia I Dawson; N Picard; Peter D Hobbs; Magnus Pfahl
A novel class of retinoid antagonists and their mechanism of action.
The Journal of biological chemistry 1996;271(20):11897-903.
1996: Masahiro Kizaki; Marcia I Dawson; R Heyman; E Elster; Roberta Morosetti; Seppo Pakkala; D L Chen; H Ueno; W Chao; M Morikawa; Yasuo Ikeda; D Heber; M Pfahl; H Phillip Koeffler
Effects of novel retinoid X receptor-selective ligands on myeloid leukemia differentiation and proliferation in vitro.
Blood 1996;87(5):1977-84.
1995: X S Li; Zhi-min Shao; M S Sheikh; Julie L Eiseman; DL Sentz; A M Jetten; J C Chen; Marcia I Dawson; Seena Aisner; Arun K Rishi
Retinoic acid nuclear receptor beta inhibits breast carcinoma anchorage independent growth.
Journal of cellular physiology 1995;165(3):449-58.
1995: Marcia I Dawson; Wan-Ru Chao; P Pine; Ling Jong; Peter D Hobbs; C K Rudd; T C Quick; Richard M Niles; Xiao-kun Zhang; A Lombardo
Correlation of retinoid binding affinity to retinoic acid receptor alpha with retinoid inhibition of growth of estrogen receptor-positive MCF-7 mammary carcinoma cells.
Cancer research 1995;55(19):4446-51.
1995: M S Sheikh; Zhi-min Shao; X S Li; J V Ordonez; BA Conley; S Wu; Marcia I Dawson; Qi-Xia Han; Wan-Ru Chao; T Quick
N-(4-hydroxyphenyl)retinamide (4-HPR)-mediated biological actions involve retinoid receptor-independent pathways in human breast carcinoma.
Carcinogenesis 1995;16(10):2477-86.
1995: Marcia I Dawson; Ling Jong; Peter D Hobbs; J F Cameron; Wan-Ru Chao; Magnus Pfahl; M O Lee; B Shroot; M Pfahl
Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.
Journal of medicinal chemistry 1995;38(17):3368-83.
1995: Zhi-min Shao; Marcia I Dawson; X S Li; Arun K Rishi; M S Sheikh; Qi-Xia Han; J V Ordonez; B Shroot; Joseph A Fontana
p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells.
Oncogene 1995;11(3):493-504.
1995: Zhi-min Shao; M S Sheikh; Arun K Rishi; Marcia I Dawson; X S Li; JF Wilber; Pei Feng; Joseph A Fontana
Thyroid hormone enhancement of estradiol stimulation of breast carcinoma proliferation.
Experimental cell research 1995;218(1):1-8.
1995: Reuben Lotan; Marcia I Dawson; C C Zou; Ling Jong; Dafna Lotan; CP Zou
Enhanced efficacy of combinations of retinoic acid- and retinoid X receptor-selective retinoids and alpha-interferon in inhibition of cervical carcinoma cell proliferation.
Cancer research 1995;55(2):232-6.
1994: A Fanjul; Marcia I Dawson; Peter D Hobbs; Ling Jong; J F Cameron; E Harlev; G Graupner; X P Lu; Magnus Pfahl
A new class of retinoids with selective inhibition of AP-1 inhibits proliferation.
Nature 1994;372(6501):107-11.
1994: Marcia I Dawson; Elena Elstner; Masahiro Kizaki; D L Chen; Seppo Pakkala; B Kerner; H Phillip Koeffler
Myeloid differentiation mediated through retinoic acid receptor/retinoic X receptor (RXR) not RXR/RXR pathway.
Blood 1994;84(2):446-52.
1994: M O Lee; Peter D Hobbs; Xiao-kun Zhang; Marcia I Dawson; Magnus Pfahl
A synthetic retinoid antagonist inhibits the human immunodeficiency virus type 1 promoter.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5632-6.
1994: A Lombardo; E Costa; Wan-Ru Chao; L Toll; Peter D Hobbs; Ling Jong; M O Lee; Magnus Pfahl; Kathryn R Ely; Marcia I Dawson
Recombinant human retinoic acid receptor beta. Binding of synthetic retinoids and transcriptional activation.
The Journal of biological chemistry 1994;269(10):7297-303.
1993: C J Rudd; J N Mansbridge; K D Suing; Marcia I Dawson
Correlation of the ability of retinoids to inhibit promoter-induced anchorage-independent growth of JB6 mouse epidermal cells with their activation of retinoic acid receptor gamma.
Cancer letters 1993;73(1):41-9.
1993: Ling Jong; Jurgen Lehmann; Peter D Hobbs; E Harlev; J C Huffman; Magnus Pfahl; Marcia I Dawson
Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity.
Journal of medicinal chemistry 1993;36(18):2605-13.
1993: A Sakashita; Masahiro Kizaki; Seppo Pakkala; G Schiller; N Tsuruoka; R Tomosaki; J F Cameron; Marcia I Dawson; H Phillip Koeffler
9-cis-retinoic acid: effects on normal and leukemic hematopoiesis in vitro.
Blood 1993;81(4):1009-16.
1992: Jurgen Lehmann; Ling Jong; A Fanjul; J F Cameron; X P Lu; P Haefner; Marcia I Dawson; Magnus Pfahl
Retinoids selective for retinoid X receptor response pathways.
Science (New York, N.Y.) 1992;258(5090):1944-6.
1992: Xiao-kun Zhang; J Lehmann; B Hoffmann; Marcia I Dawson; J Cameron; G Graupner; T Hermann; P Tran; Magnus Pfahl
Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid.
Nature 1992;358(6387):587-91.
1991: Jurgen Lehmann; Marcia I Dawson; Peter D Hobbs; M Husmann; Magnus Pfahl
Identification of retinoids with nuclear receptor subtype-selective activities.
Cancer research 1991;51(18):4804-9.
1990: Marcia I Dawson; A N Jina; S Torkelson; S Rhee; M Moore; D A Zarling; Peter D Hobbs
Synthesis and characterization of a ribavirin-3',5'-phosphate pentadecamer homoribopolymer bearing a 5'-amino tether group and a 3'-thymidine.
Nucleic acids research 1990;18(5):1099-102.
1990: Brahma P Sani; J J Wille; Marcia I Dawson; Peter D Hobbs; J Bupp; S Rhee; Wan-Ru Chao; A Dorsky; H Morimoto
Biologically active aromatic retinoids bearing azido photoaffinity-labeling groups and their binding to cellular retinoic acid-binding protein.
Chemico-biological interactions 1990;75(3):293-304.
1989: Marcia I Dawson; Peter D Hobbs; K A Derdzinski; Wan-Ru Chao; G Frenking; GH Loew; A M Jetten; J L Napoli; J B Williams; Brahma P Sani
Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids.
Journal of medicinal chemistry 1989;32(7):1504-17.
1988: Marcia I Dawson; Wan-Ru Chao
Comparison of the inhibitory effects of retinoids on 12-O-tetradecanoylphorbol-13-acetate-promoted tumor formation in CD-1 and Sencar mice.
Cancer letters 1988;40(1):7-12.
1988: Joseph A Fontana; P D Hobbs; Marcia I Dawson
Inhibition of mammary carcinoma growth by retinoidal benzoic acid derivatives.
Experimental cell biology 1988;56(5):254-63.
1987: Marcia I Dawson; Wan-Ru Chao; C T Helmes
Inhibition by retinoids of anthralin-induced mouse epidermal ornithine decarboxylase activity and anthralin-promoted skin tumor formation.
Cancer research 1987;47(23):6210-5.
1985: Wan-Ru Chao; C T Helmes; Marcia I Dawson
Comparison of the inhibitory effects of retinoids on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activities in CD-1 and Sencar mice.
Cancer letters 1985;29(1):43-8.
1985: Marcia I Dawson; Peter D Hobbs; R Chan; K Derdzinski; C T Helmes; W Chao; E Meierhenry; L J Schiff
Conformational restrictions of the retinoid skeleton.
Ciba Foundation symposium 1985;113():6-28.
1984: Marcia I Dawson; Peter D Hobbs; K Derdzinski; R L Chan; J Gruber; Wan-Ru Chao; S Smith; R W Thies; L J Schiff
Conformationally restricted retinoids.
Journal of medicinal chemistry 1984;27(11):1516-31.
1984: Brahma P Sani; Marcia I Dawson; Peter D Hobbs; R L Chan; L J Schiff
Relationship between binding affinities to cellular retinoic acid-binding protein and biological potency of a new series of retinoids.
Cancer research 1984;44(1):190-5.
1983: Marcia I Dawson; R L Chan; K Derdzinski; Peter D Hobbs; Wan-Ru Chao; L J Schiff
Synthesis and pharmacological activity of 6-[(E)-2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethen-1-yl]- and 6-(1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-6-naphthyl)-2-naphthalenecarboxylic acids.
Journal of medicinal chemistry 1983;26(11):1653-6.
1983: Marcia I Dawson; R Chan; Peter D Hobbs; Wan-Ru Chao; L J Schiff
Aromatic retinoic acid analogues. 2. Synthesis and pharmacological activity.
Journal of medicinal chemistry 1983;26(9):1282-93.
1981: Marcia I Dawson; Peter D Hobbs; R L Chan; Wan-Ru Chao
Retinoic acid analogues with ring modifications. Synthesis and pharmacological activity.
Journal of medicinal chemistry 1981;24(10):1214-23.
1981: Marcia I Dawson; Peter D Hobbs; R L Chan; Wan-Ru Chao; V A Fung
Aromatic retinoic acid analogues. Synthesis and pharmacological activity.
Journal of medicinal chemistry 1981;24(5):583-92.
1980: Marcia I Dawson; Peter D Hobbs; K Kuhlmann; V A Fung; C T Helmes; Wan-Ru Chao
Retinoic acid analogues. Synthesis and potential as cancer chemopreventive agents.
Journal of medicinal chemistry 1980;23(9):1013-22.