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Colin Dayan

Research Profile

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Hormone Replacement Therapy

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Rajeev P Raghavan; Peter N Taylor; Bijay Vaidya; Luigi Bartalena; Ragini Bhake; Colin M Dayan; Enio Martino; Karin Bradley
Amiodarone-induced thyrotoxicosis, an overview of UK management.
A R Cooper; Colin M Dayan; K Fitzsimons; N Jackson; A A Montgomery; T J Peters; S Sebire; D J Sharp; R C Andrews
Sedentary time, breaks in sedentary time and metabolic variables in people with newly diagnosed type 2 diabetes.
Sefina Arif; Thomas Bouckenooghe; Colin M Dayan; Decio L Eizirik; Esteban N Gurzov; Guo Cai Huang; Piero Marchetti; Katherine Marks; Fabrice Moore; Raquel Planas; Jake Powrie; Ricardo Pujol Borrell; tim tree; Marta Vives-Pi; Mark Peakman
Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death.

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All Publications

2012: Rajeev P Raghavan; Peter N Taylor; Bijay Vaidya; Luigi Bartalena; Ragini Bhake; Colin M Dayan; Enio Martino; Karin Bradley
Amiodarone-induced thyrotoxicosis, an overview of UK management.
Clinical endocrinology 2012;77(6):936-7.
2012: A R Cooper; Colin M Dayan; K Fitzsimons; N Jackson; A A Montgomery; T J Peters; S Sebire; D J Sharp; R C Andrews
Sedentary time, breaks in sedentary time and metabolic variables in people with newly diagnosed type 2 diabetes.
Diabetologia 2012;55(3):589-99.
2011: Sefina Arif; Thomas Bouckenooghe; Colin M Dayan; Decio L Eizirik; Esteban N Gurzov; Guo Cai Huang; Piero Marchetti; Katherine Marks; Fabrice Moore; Raquel Planas; Jake Powrie; Ricardo Pujol Borrell; tim tree; Marta Vives-Pi; Mark Peakman
Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death.
Diabetes 2011;60(8):2112-9.
2011: R C Andrews; J Bright; A R Cooper; K Coulman; C Y England; K Fitzsimons; J Gorton; N Jackson; A McLenaghan; A A Montgomery; Alastair J Norcross; E Paxton; Tim J Peters; A Polet; Deborah J Sharp; C Thompson; Colin M Dayan
Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial.
Lancet 2011;378(9786):129-39.
2011: Peter N Taylor; Nicholas J Timpson; Jonathan H Tobias; Bijay Vaidya; John P Walsh; John P Beilby; Alexandra P Bremner; Jonathan Evans; Timothy Frayling; Andrew T Hattersley; Ahmed Iqbal; Peter J Leedman; Vijay Panicker; Adrian Sayers; Beverley Shields; Colin M Dayan
A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement.
European journal of endocrinology / European Federation of Endocrine Societies 2011;164(5):773-80.
2011: A J di Mambro; R Parker; A McCune; F Gordon; Colin M Dayan; P Collins
In vitro steroid resistance correlates with outcome in severe alcoholic hepatitis.
Hepatology (Baltimore, Md.) 2011;53(4):1316-22.
2010: L G Petrich de Marquesini; J Fu; K J Connor; Amanda J Bishop; N E McLintock; C Pope; F Susan Wong; Colin M Dayan
IFN-gamma and IL-10 islet-antigen-specific T cell responses in autoantibody-negative first-degree relatives of patients with type 1 diabetes.
Diabetologia 2010;53(7):1451-60.
2010: Nicolle Kraenkel; Stephen Paul Armstrong; Craig Alexander McArdle; Colin M Dayan; Paolo Madeddu
Distinct kinin-induced functions are altered in circulating cells of young type 1 diabetic patients.
PloS one 2010;5(6):e11146.
2009: Vijay Panicker; Jonathan Evans; Trine Bjøro; Bjorn O Asvold; Colin M Dayan; Ottar Bjerkeset
A paradoxical difference in relationship between anxiety, depression and thyroid function in subjects on and not on T4: findings from the HUNT study.
Clinical endocrinology 2009;71(4):574-80.
2009: Thomas J Creed; Richard W Lee; Paul V Newcomb; Alexandra J di Mambro; Madhuri Raju; Colin M Dayan
The effects of cytokines on suppression of lymphocyte proliferation by dexamethasone.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):164-71.
2009: Vijay Panicker; Ponnusamy Saravanan; Bijay Vaidya; Jonathan Evans; Andrew T Hattersley; Timothy M Frayling; Colin M Dayan
Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients.
The Journal of clinical endocrinology and metabolism 2009;94(5):1623-9.
2009: Colin M Dayan; Vijay Panicker
Novel insights into thyroid hormones from the study of common genetic variation.
Nature reviews. Endocrinology 2009;5(4):211-8.
2009: M D Williams; R Harris; Colin M Dayan; Jonathan Evans; John Gallacher; Yoav Ben-Shlomo
Thyroid function and the natural history of depression: findings from the Caerphilly Prospective Study (CaPS) and a meta-analysis.
Clinical endocrinology 2009;70(3):484-92.
2009: S L Thrower; L James; W Hall; K M Green; Sefina Arif; J S Allen; C Van-Krinks; B Lozanoska-Ochser; L Marquesini; S Brown; F S Wong; Colin M Dayan; Mark Peakman
Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study.
Clinical and experimental immunology 2009;155(2):156-65.
2009: Lauren P Schewitz; Richard W J Lee; Colin M Dayan; Andrew D Dick
Glucocorticoids and the emerging importance of T cell subsets in steroid refractory diseases.
Immunopharmacology and immunotoxicology 2009;31(1):1-22.
2009: Jennifer S Allen; Karl Pang; Ania Skowera; Richard Ellis; Chloe Rackham; Biliana Lozanoska-Ochser; tim tree; R David G Leslie; Jennifer M Tremble; Colin M Dayan; Mark Peakman
Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture.
Diabetes 2009;58(1):138-45.
2008: J M Lawson; Jennifer M Tremble; Colin M Dayan; H Beyan; R David G Leslie; Mark Peakman; tim tree
Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes.
Clinical and experimental immunology 2008;154(3):353-9.
2008: Aidan Searle; Lone Gale; Rona Campbell; Mark Wetherell; Karen Dawe; Nikki Drake; Colin M Dayan; John F Tarlton; Jeremy Miles; Kavita Vedhara
Reducing the burden of chronic wounds: prevention and management of the diabetic foot in the context of clinical guidelines.
Journal of health services research & policy 2008;13 Suppl 3():82-91.
2008: Anna Skowera; Richard J Ellis; Ruben Varela-Calviño; Sefina Arif; Guo Huang; Cassie Van-Krinks; Anna Zaremba; Chloe Rackham; Jennifer S Allen; tim tree; Min Zhao; Colin M Dayan; Andrew K Sewell; wendy unger; Wendy Unger; Jan W Drijfhout; Ferry Ossendorp; Bart O Roep; Mark Peakman
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
The Journal of clinical investigation 2008;118(10):3390-402.
2008: F Susan Wong; Colin M Dayan
Regulatory T cells in autoimmune endocrine diseases.
Trends in endocrinology and metabolism: TEM 2008;19(8):292-9.
2008: Vijay Panicker; Christie Cluett; Beverley Shields; Anna Murray; Kirstie S Parnell; John R B Perry; Michael N Weedon; Andrew Singleton; Dena Hernandez; Jonathan Evans; Claire Durant; Luigi Ferrucci; David Melzer; Ponnusamy Saravanan; Theo J Visser; Graziano Ceresini; Andrew T Hattersley; Bijay Vaidya; Colin M Dayan; Timothy M Frayling
A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine.
The Journal of clinical endocrinology and metabolism 2008;93(8):3075-81.
2008: Caroline Baker; Liliana G Petrich de Marquesini; Amanda J Bishop; Alan J Hedges; Colin M Dayan; F Susan Wong
Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery.
Journal of clinical immunology 2008;28(4):350-60.
2008: Colin M Dayan; David C Wraith
Preparing for first-in-man studies: the challenges for translational immunology post-TGN1412.
Clinical and experimental immunology 2008;151(2):231-4.
2008: Rathie Rajendram; Richard W J Lee; MJ Potts; Geoff E Rose; Rajni Jain; Jane M Olver; Fion Bremner; Steven J Hurel; Anne Cook; Rao Gattamaneni; Marjorie Tomlinson; Nicholas Plowman; Catey Bunce; Sandra P Hollinghurst; Laura Kingston; Sue Jackson; Andrew D Dick; N Rumsey; Olivia C Morris; Colin M Dayan; Jimmy M Uddin
Protocol for the combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: a multi-centre, double-masked, factorial randomised controlled trial.
Trials 2008;9():6.
2007: Richard W J Lee; Thomas J Creed; Lauren P Schewitz; Paul V Newcomb; Lindsay B Nicholson; Andrew D Dick; Colin M Dayan
CD4+CD25(int) T cells in inflammatory diseases refractory to treatment with glucocorticoids.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7941-8.
2007: Ponnusamy Saravanan; H Siddique; D J Simmons; Rosemary Jane Greenwood; Colin M Dayan
Twenty-four hour hormone profiles of TSH, Free T3 and free T4 in hypothyroid patients on combined T3/T4 therapy.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2007;115(4):261-7.
2007: C Baker; L Chang; Kathryn Elsegood; Amanda J Bishop; D H Gannon; Parth Narendran; Nicola J Leech; Colin M Dayan
Activated T cell subsets in human type 1 diabetes: evidence for expansion of the DR+ CD30+ subpopulation in new-onset disease.
Clinical and experimental immunology 2007;147(3):472-82.
2007: Alistair J K Williams; W Chau; M P Callaway; Colin M Dayan
Magnetic resonance imaging: a reliable method for measuring pancreatic volume in Type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(1):35-40.
2006: Ponnusamy Saravanan; Theo J Visser; Colin M Dayan
Psychological well-being correlates with free thyroxine but not free 3,5,3'-triiodothyronine levels in patients on thyroid hormone replacement.
The Journal of clinical endocrinology and metabolism 2006;91(9):3389-93.
2006: Thomas J Creed; C S J Probert; M N Norman; Moganaden Moorghen; N A Shepherd; Stephen D Hearing; Colin M Dayan
Basiliximab for the treatment of steroid-resistant ulcerative colitis: further experience in moderate and severe disease.
Alimentary pharmacology & therapeutics 2006;23(10):1435-42.
2005: Ponnusamy Saravanan; Dawn J Simmons; Rosemary Jane Greenwood; Tim J Peters; Colin M Dayan
Partial substitution of thyroxine (T4) with tri-iodothyronine in patients on T4 replacement therapy: results of a large community-based randomized controlled trial.
The Journal of clinical endocrinology and metabolism 2005;90(2):805-12.
2005: Shelley Lindley; Colin M Dayan; Amanda Bishop; Bart O Roep; Mark Peakman; tim tree
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.
Diabetes 2005;54(1):92-9.
2004: Parth Narendran; Kathryn Elsegood; Nicola J Leech; Wallace M Macindoe; Gerardus Josephus Boons; Colin M Dayan
Dendritic cell-based assays, but not mannosylation of antigen, improves detection of T-cell responses to proinsulin in type 1 diabetes.
Immunology 2004;111(4):422-9.
2004: Sefina Arif; tim tree; Thomas P Astill; Jennifer M Tremble; Amanda J Bishop; Colin M Dayan; Bart O Roep; Mark Peakman
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health.
The Journal of clinical investigation 2004;113(3):451-63.
2003: C Baker; Louise J Richards; Colin M Dayan; David S Jessop
Corticotropin-releasing hormone immunoreactivity in human T and B cells and macrophages: colocalization with arginine vasopressin.
Journal of neuroendocrinology 2003;15(11):1070-4.
2003: Colin M Dayan
Human monoclonal thyroid-stimulating autoantibody: how useful is a holy grail?
Lancet 2003;362(9378):92-3.
2003: Colin M Dayan
Misconceptions in thyroid eye disease.
The Practitioner 2003;247(1648):570-2, 576-80.
2003: Thomas J Creed; M R Norman; C S J Probert; Richard F Harvey; Ian S Shaw; J Smithson; J Anderson; Moganaden Moorghen; Jyoti Gupta; N A Shepherd; Colin M Dayan; Stephen D Hearing
Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis.
Alimentary pharmacology & therapeutics 2003;18(1):65-75.
2003: Parth Narendran; Alistair J Williams; Kathryn Elsegood; Nicola J Leech; Colin M Dayan
Humoral and cellular immune responses to proinsulin in adults with newly diagnosed type 1 diabetes.
Diabetes/metabolism research and reviews 2003;19(1):52-9.
2002: Ponnusamy Saravanan; W-F Chau; N Roberts; K Vedhara; Rosemary Jane Greenwood; Colin M Dayan
Psychological well-being in patients on 'adequate' doses of l-thyroxine: results of a large, controlled community-based questionnaire study.
Clinical endocrinology 2002;57(5):577-85.
2002: Colin M Dayan; Ponnusamy Saravanan; Graham Bayly
Whose normal thyroid function is better--yours or mine?
Lancet 2002;360(9330):353.
2002: Ruben Varela-Calvino; Richard Ellis; Gianluca Sgarbi; Colin M Dayan; Mark Peakman
Characterization of the T-cell response to coxsackievirus B4: evidence that effector memory cells predominate in patients with type 1 diabetes.
Diabetes 2002;51(6):1745-53.
2002: Parth Narendran; Kathryn Elsegood; Nicola J Leech; Colin M Dayan
Dendritic cell-based proliferative assays of peripheral T cell responses to tetanus toxoid.
Annals of the New York Academy of Sciences 2002;958():170-4.
2001: Mark Peakman; Colin M Dayan
Antigen-specific immunotherapy for autoimmune disease: fighting fire with fire?
Immunology 2001;104(4):361-6.
2001: Ruben Varela-Calvino; Gianluca Sgarbi; L R Wedderburn; Colin M Dayan; Jennifer M Tremble; Mark Peakman
T cell activation by coxsackievirus B4 antigens in type 1 diabetes mellitus: evidence for selective TCR Vbeta usage without superantigenic activity.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(6):3513-20.
2001: Ponnusamy Saravanan; Colin M Dayan
Thyroid autoantibodies.
Endocrinology and metabolism clinics of North America 2001;30(2):315-37, viii.
2001: Colin M Dayan
Interpretation of thyroid function tests.
Lancet 2001;357(9256):619-24.
2000: J P Walsh; Colin M Dayan
Role of biochemical assessment in management of corticosteroid withdrawal.
Annals of clinical biochemistry 2000;37 ( Pt 3)():279-88.
2000: R Maile; Kathryn Elsegood; Tom Harding; James B Uney; C E Stewart; George Banting; Colin M Dayan
Effective formation of major histocompatibility complex class II-peptide complexes from endogenous antigen by thyroid epithelial cells.
Immunology 2000;99(3):367-74.
1999: Stephen D Hearing; Michael Norman; C Smyth; C Foy; Colin M Dayan
Wide variation in lymphocyte steroid sensitivity among healthy human volunteers.
The Journal of clinical endocrinology and metabolism 1999;84(11):4149-54.
1999: Stephen D Hearing; Michael Norman; C S J Probert; N Haslam; Colin M Dayan
Predicting therapeutic outcome in severe ulcerative colitis by measuring in vitro steroid sensitivity of proliferating peripheral blood lymphocytes.
Gut 1999;45(3):382-8.
1999: J P Walsh; Colin M Dayan; M J Potts
Radioiodine and thyroid eye disease.
BMJ (Clinical research ed.) 1999;319(7202):68-9.
1999: Stephen D Hearing; Michael Norman; Colin M Dayan
In vitro measurement of lymphocyte steroid sensitivity: lack of agreement between whole blood culture and separated lymphocyte culture.
Immunopharmacology and immunotoxicology 1999;21(1):41-53.
1998: Nicola J Leech; Colin M Dayan
Controversies in the management of Graves' disease.
Clinical endocrinology 1998;49(3):273-80.
1997: R Maile; Kathryn Elsegood; Colin M Dayan
Functionality of inducible major histocompatibility class II expression by specialised non-lymphoid cells.
Biochemical Society transactions 1997;25(2):318S.
1997: Colin M Dayan; Kathryn Elsegood; R Maile
FasL expression on epithelial cells: the Bottazzo-Feldman hypothesis revisited.
Immunology today 1997;18(5):203.
1997: David S Jessop; Michael S Harbuz; C L Snelson; Colin M Dayan; Stafford L Lightman
An antisense oligodeoxynucleotide complementary to corticotropin-releasing hormone mRNA inhibits rat splenocyte proliferation in vitro.
Journal of neuroimmunology 1997;75(1-2):135-40.