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Osmond D'Cruz

Research Profile

Chemicals & Drugs

Procedures

Administration, Intravaginal

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Anatomy

Physiology

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HIV Infections

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Publications

TOP 3
Osmond J D'Cruz; Fatih M Uckun
Protein kinase inhibitors against malignant lymphoma.
Osmond J D'Cruz; Fatih M Uckun
Novel Bruton's tyrosine kinase inhibitors currently in development.
fatih uckun; Sanjive Qazi; Pedro Cahn; Osmond J D'Cruz
Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS.

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All Publications

2013: Osmond J D'Cruz; Fatih M Uckun
Protein kinase inhibitors against malignant lymphoma.
Expert opinion on pharmacotherapy 2013;14(6):707-21.
2013: Osmond J D'Cruz; Fatih M Uckun
Novel Bruton's tyrosine kinase inhibitors currently in development.
OncoTargets and therapy 2013;6():161-76.
2012: fatih uckun; Sanjive Qazi; Pedro Cahn; Osmond J D'Cruz
Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS.
Expert opinion on investigational drugs 2012;21(4):489-500.
2012: Osmond J D'Cruz; Sanjive Qazi; Seang Yiv; fatih uckun
A novel vaginal microbicide containing the rationally designed anti-HIV compound HI-443 (N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea]).
Expert opinion on investigational drugs 2012;21(3):265-79.
2008: Osmond J D'Cruz; fatih uckun
Evaluation of local tolerance of the antiretroviral spermicide (WHI-07)-loaded gel-microemulsion in the porcine female reproductive tract.
Journal of applied toxicology : JAT 2008;28(3):303-14.
2008: Osmond J D'Cruz; fatih uckun
Microbicides for multidrug-resistant and multitropic HIV-1.
Current opinion in investigational drugs (London, England : 2000) 2008;9(2):152-69.
2007: Osmond J D'Cruz; fatih uckun
Preclinical evaluation of a dual-acting microbicidal prodrug WHI-07 in combination with vanadocene dithiocarbamate in the female reproductive tract of rabbit, pig, and cat.
Toxicologic pathology 2007;35(7):910-27.
2007: Osmond J D'Cruz; fatih uckun
Mucosal safety of PHI-443 and stampidine as a combination microbicide to prevent genital transmission of HIV-1.
Fertility and sterility 2007;88(4 Suppl):1197-206.
2007: Osmond J D'Cruz; fatih uckun
Targeting mast cells in endometriosis with janus kinase 3 inhibitor, JANEX-1.
American journal of reproductive immunology (New York, N.Y. : 1989) 2007;58(2):75-97.
2007: Osmond J D'Cruz; fatih uckun
Limitations of the human-PBL-SCID mouse model for vaginal transmission of HIV-1.
American journal of reproductive immunology (New York, N.Y. : 1989) 2007;57(5):353-60.
2006: Osmond J D'Cruz; fatih uckun
Novel tight binding PETT, HEPT and DABO-based non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Journal of enzyme inhibition and medicinal chemistry 2006;21(4):329-50.
2006: Osmond J D'Cruz; fatih uckun
Novel broad-spectrum thiourea non-nucleoside inhibitors for the prevention of mucosal HIV transmission.
Current HIV research 2006;4(3):329-45.
2006: Osmond J D'Cruz; fatih uckun
Dawn of non-nucleoside inhibitor-based anti-HIV microbicides.
The Journal of antimicrobial chemotherapy 2006;57(3):411-23.
2006: Osmond J D'Cruz; Douglas Erbeck; fatih uckun
Developmental safety profile of the anti-HIV agent stampidine in rabbits.
Arzneimittel-Forschung 2006;56(2A):159-66.
2006: Osmond J D'Cruz; fatih uckun
Influence of long-term stability conditions on microbicidal nucleoside prodrug (WHI-07)-loaded gel-microemulsion.
AAPS PharmSciTech 2006;7(3):73.
2005: Osmond J D'Cruz; fatih uckun
Discovery of 2,5-dimethoxy-substituted 5-bromopyridyl thiourea (PHI-236) as a potent broad-spectrum anti-human immunodeficiency virus microbicide.
Molecular human reproduction 2005;11(10):767-77.
2005: Osmond J D'Cruz; fatih uckun
Vaginal contraceptive activity of a chelated vanadocene.
Contraception 2005;72(2):146-56.
2005: Osmond J D'Cruz; fatih uckun
Stampidine: a selective oculo-genital microbicide.
The Journal of antimicrobial chemotherapy 2005;56(1):10-9.
2005: Osmond J D'Cruz; Peter Samuel; fatih uckun
Conceival, a novel noncontraceptive vaginal vehicle for lipophilic microbicides.
AAPS PharmSciTech 2005;6(1):E56-64.
2005: Osmond J D'Cruz; Douglas Erbeck; fatih uckun
A study of the potential of the pig as a model for the vaginal irritancy of benzalkonium chloride in comparison to the nonirritant microbicide PHI-443 and the spermicide vanadocene dithiocarbamate.
Toxicologic pathology 2005;33(4):465-76.
2005: fatih uckun; Hung-Liang Tai; Osmond J D'Cruz
Antileukemic activity and cellular metabolism of the aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07).
Arzneimittel-Forschung 2005;55(1):50-65.
2004: Osmond J D'Cruz; Peter Samuel; fatih uckun
PHI-443: a novel noncontraceptive broad-spectrum anti-human immunodeficiency virus microbicide.
Biology of reproduction 2004;71(6):2037-47.
2004: Osmond J D'Cruz; Barbara Waurzyniak; fatih uckun
Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats.
Antimicrobial agents and chemotherapy 2004;48(4):1082-8.
2004: Osmond J D'Cruz; Barbara Waurzyniak; fatih uckun
Mucosal toxicity studies of a gel formulation of native pokeweed antiviral protein.
Toxicologic pathology 2004;32(2):212-21.
2004: Osmond J D'Cruz; fatih uckun
Stampidine is a potential nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide.
Fertility and sterility 2004;81 Suppl 1():831-41.
2004: Osmond J D'Cruz; B Waurzyniakt; fatih uckun
A 13-week subchronic intravaginal toxicity study of pokeweed antiviral protein in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2004;11(4):342-51.
2004: Osmond J D'Cruz; fatih uckun
Clinical development of microbicides for the prevention of HIV infection.
Current pharmaceutical design 2004;10(3):315-36.
2003: Osmond J D'Cruz; Peter Samuel; Barbara Waurzyniak; fatih uckun
Development and evaluation of a thermoreversible ovule formulation of stampidine, a novel nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide.
Biology of reproduction 2003;69(6):1843-51.
2003: Osmond J D'Cruz; Douglas Erbeck; fatih uckun
Developmental toxicology studies of WHI-07, a novel nucleoside analogue-based dual-function microbicide, administered intravaginally to rabbits.
Toxicologic pathology 2003;31(6):698-708.
2003: Osmond J D'Cruz; fatih uckun
Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07) in rabbits.
Fertility and sterility 2003;79(4):864-72.
2003: Osmond J D'Cruz; Yanhong Dong; fatih uckun
Potent dual anti-HIV and spermicidal activities of novel oxovanadium(V) complexes with thiourea non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Biochemical and biophysical research communications 2003;302(2):253-64.
2003: Osmond J D'Cruz; fatih uckun
Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-05) in rabbits.
Arzneimittel-Forschung 2003;53(7):515-21.
2003: fatih uckun; Osmond J D'Cruz; Xing-Ping Liu; Rama Krishna Narla
Phenylarsonic acid compounds with broad-spectrum and potent cytotoxic activity against human cancer cells.
Arzneimittel-Forschung 2003;53(6):428-39.
2002: Osmond J D'Cruz; fatih uckun
Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07).
The Journal of antimicrobial chemotherapy 2002;50(6):793-803.
2002: Osmond J D'Cruz; fatih uckun
Metvan: a novel oxovanadium(IV) complex with broad spectrum anticancer activity.
Expert opinion on investigational drugs 2002;11(12):1829-36.
2002: Osmond J D'Cruz; Taracad K Venkatachalam; Chen Mao; Sanjive Qazi; fatih uckun
Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Biology of reproduction 2002;67(6):1959-74.
2002: Osmond J D'Cruz; Barbara Waurzyniak; fatih uckun
A 13-week subchronic intravaginal toxicity study of the novel broad-spectrum anti-HIV and spermicidal agent, N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea (PHI-346) in mice.
Toxicologic pathology 2002;30(6):687-95.
2002: Osmond J D'Cruz; Douglas Erbeck; Barbara Waurzyniak; fatih uckun
Two-year toxicity and carcinogenicity studies in B(6)C(3)F(1) mice with 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent.
Toxicology 2002;179(1-2):61-77.
2002: Osmond J D'Cruz; Barbara Waurzyniak; fatih uckun
Subchronic (13-week) toxicity studies of intravaginal administration of spermicidal vanadocene acetylacetonato monotriflate in mice.
Toxicology 2002;170(1-2):31-43.
2002: fatih uckun; Xing Ping Liu; Osmond J D'Cruz
Human sperm immobilizing activity of aminophenyl arsenic acid and its N-substituted quinazoline, pyrimidine, and purine derivatives: protective effect of glutathione.
Reproductive toxicology (Elmsford, N.Y.) 2002;16(1):57-64.
2001: Osmond J D'Cruz; fatih uckun
Effect of pretreatment of semen with pokeweed antiviral protein on pregnancy outcome in the rabbit model.
Fertility and sterility 2001;76(4):830-3.
2001: Osmond J D'Cruz; Barbara Waurzyniak; fatih uckun
Subchronic (13-week) toxicity studies of intravaginal administration of spermicidal vanadocene dithiocarbamate in mice.
Contraception 2001;64(3):177-85.
2001: Osmond J D'Cruz; fatih uckun
Gel-microemulsions as vaginal spermicides and intravaginal drug delivery vehicles.
Contraception 2001;64(2):113-23.
2001: Osmond J D'Cruz; A O Vassilev; fatih uckun
Members of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway are present and active in human sperm.
Fertility and sterility 2001;76(2):258-66.
2001: Osmond J D'Cruz; fatih uckun
Bis(4,7-dimethyl and 5-dinitro-1,10-phenanthroline) sulfato-oxovanadium(IV)-mediated in vivo male germ cell apoptosis.
Journal of applied toxicology : JAT 2001;21(4):331-9.
2001: Osmond J D'Cruz; fatih uckun
Lack of adverse effects on fertility of female CD-1 mice exposed to repetitive intravaginal gel-microemulsion formulation of a dual-function anti-HIV agent: aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07).
Journal of applied toxicology : JAT 2001;21(4):317-22.
2001: Osmond J D'Cruz; fatih uckun
Short-Term (13-week) toxicity study of 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent, in B6C3F1 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2001;60(2):373-8.
2001: Osmond J D'Cruz; fatih uckun
Intravaginal toxicity studies of a gel-microemulsion formulation of spermicidal vanadocenes in rabbits.
Toxicology and applied pharmacology 2001;170(2):104-12.
2001: Osmond J D'Cruz; SH Yiv; fatih uckun
GM-144, a novel lipophilic vaginal contraceptive gel-microemulsion.
AAPS PharmSciTech 2001;2(2):E5.
2001: Osmond J D'Cruz; SH Yiv; Barbara Waurzyniak; fatih uckun
Contraceptive efficacy and safety studies of a novel microemulsion-based lipophilic vaginal spermicide.
Fertility and sterility 2001;75(1):115-24.
2001: Osmond J D'Cruz; fatih uckun
Pokeweed antiviral protein: a potential nonspermicidal prophylactic antiviral agent.
Fertility and sterility 2001;75(1):106-14.
2000: Osmond J D'Cruz; Y Dong; fatih uckun
Apoptosis-inducing oxovanadium(IV) complexes of 1,10-phenanthroline against human ovarian cancer.
Anti-cancer drugs 2000;11(10):849-58.
2000: Osmond J D'Cruz; fatih uckun
Vanadocene-mediated in vivo male germ cell apoptosis.
Toxicology and applied pharmacology 2000;166(3):186-95.
2000: Osmond J D'Cruz; Barbara Waurzyniak; SH Yiv; fatih uckun
Evaluation of subchronic (13-week) and reproductive toxicity potential of intravaginal gel-microemulsion formulation of a dual-function phenyl phosphate derivative of bromo-methoxy zidovudine (compound whi-07) in B(6)C(3)F(1) mice.
Journal of applied toxicology : JAT 2000;20(4):319-25.
2000: Osmond J D'Cruz; A Vassilev; fatih uckun
Evaluation of boar sperm as a model system to study the mechanism of spermicidal activity of vanadocenes.
Biochemical and biophysical research communications 2000;270(3):826-30.
2000: Rama Krishna Narla; Y Dong; Osmond J D'Cruz; Christopher S Navara; fatih uckun
Bis(4,7-dimethyl-1,10-phenanthroline) sulfatooxovanadium(IV) as a novel apoptosis-inducing anticancer agent.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1546-56.
2000: P Ghosh; Osmond J D'Cruz; Rama Krishna Narla; fatih uckun
Apoptosis-inducing vanadocene compounds against human testicular cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(4):1536-45.
2000: Osmond J D'Cruz; Barbara Waurzyniak; SH Yiv; fatih uckun
Evaluation of subchronic (13 weeks) and reproductive toxicity potential of intravaginal gel-microemulsion formulation of a dual-function phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-05) in B(6)C(3)F(1) mice.
Contraception 2000;61(1):69-76.
1999: Osmond J D'Cruz; fatih uckun
Novel derivatives of phenethyl-5-bromopyridylthiourea and dihydroalkoxybenzyloxopyrimidine are dual-function spermicides with potent anti-human immunodeficiency virus activity.
Biology of reproduction 1999;60(6):1419-28.
1999: Osmond J D'Cruz; Z Zhu; SH Yiv; CL Chen; Barbara Waurzyniak; fatih uckun
WHI-05, a novel bromo-methoxy substituted phenyl phosphate derivative of zidovudine, is a dual-action spermicide with potent anti-HIV activity.
Contraception 1999;59(5):319-31.
1999: Osmond J D'Cruz; MJ Shih; SH Yiv; CL Chen; fatih uckun
Synthesis, characterization and preclinical formulation of a dual-action phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07) with potent anti-HIV and spermicidal activities.
Molecular human reproduction 1999;5(5):421-32.
1999: ST Jan; MJ Shih; Taracad K Venkatachalam; Osmond J D'Cruz; CL Chen; fatih uckun
Synthesis of dual function (5R,6R)- and (5S,6S)-5-bromo-6-methoxy-5,6-dihydro-AZT-5'-(para-bromophenyl methoxyalaninyl phosphate) as novel spermicidal and anti-HIV agents.
Antiviral chemistry & chemotherapy 1999;10(1):39-46.
1998: Osmond J D'Cruz; Taracad K Venkatachalam; Z Zhu; MJ Shih; fatih uckun
Aryl phosphate derivatives of bromo-methoxy-azidothymidine are dual-function spermicides with potent anti-human immunodeficiency virus.
Biology of reproduction 1998;59(3):503-15.
1998: Osmond J D'Cruz; P Ghosh; fatih uckun
Spermicidal activity of chelated complexes of bis(cyclopentadienyl)vanadium(IV).
Molecular human reproduction 1998;4(7):683-93.