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Maresa Altomonte

Research Profile

Disorders

Anatomy

Tumor Cells, Cultured

Chemicals & Drugs

Procedures

Physiology

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Anna Maria Di Giacomo; Riccardo Danielli; Luana Calabrò; Erica Bertocci; Chiara Nannicini; Diana Giannarelli; Angelo Balestrazzi; Francesco Vigni; Valentina Riversi; Clelia Miracco; Maurizio Biagioli; Maresa Altomonte; Michele Maio
Ipilimumab experience in heavily pretreated patients with melanoma in an expanded access program at the University Hospital of Siena (Italy).
Ester Fonsatti; Michele Maio; Maresa Altomonte; Peter Hersey
Biology and clinical applications of CD40 in cancer treatment.
Anusha Kalbasi; Ester Fonsatti; Pier Giorgio Natali; Maresa Altomonte; Erica Bertocci; Ornella Cutaia; Luana Calabrò; Michael Chiou; William Tap; Bartosz Chmielowski; Michele Maio; Antoni Ribas
CD40 expression by human melanocytic lesions and melanoma cell lines and direct CD40 targeting with the therapeutic anti-CD40 antibody CP-870,893.

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All Publications

2011: Anna Maria Di Giacomo; Riccardo Danielli; Luana Calabrò; Erica Bertocci; Chiara Nannicini; Diana Giannarelli; Angelo Balestrazzi; Francesco Vigni; Valentina Riversi; Clelia Miracco; Maurizio Biagioli; Maresa Altomonte; Michele Maio
Ipilimumab experience in heavily pretreated patients with melanoma in an expanded access program at the University Hospital of Siena (Italy).
Cancer immunology, immunotherapy : CII 2011;60(4):467-77.
2010: Ester Fonsatti; Michele Maio; Maresa Altomonte; Peter Hersey
Biology and clinical applications of CD40 in cancer treatment.
Seminars in oncology 2010;37(5):517-23.
2010: Anusha Kalbasi; Ester Fonsatti; Pier Giorgio Natali; Maresa Altomonte; Erica Bertocci; Ornella Cutaia; Luana Calabrò; Michael Chiou; William Tap; Bartosz Chmielowski; Michele Maio; Antoni Ribas
CD40 expression by human melanocytic lesions and melanoma cell lines and direct CD40 targeting with the therapeutic anti-CD40 antibody CP-870,893.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2010;33(8):810-6.
2010: Elisabetta Fratta; Luca Sigalotti; Francesca Colizzi; Alessia Covre; hugues nicolay; Riccardo Danielli; Ester Fonsatti; Maresa Altomonte; Luana Calabrò; Sandra Coral; Michele Maio
Epigenetically regulated clonal heritability of CTA expression profiles in human melanoma.
Journal of cellular physiology 2010;223(2):352-8.
2010: Ester Fonsatti; hugues nicolay; Maresa Altomonte; Alessia Covre; Michele Maio
Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours.
Cardiovascular research 2010;86(1):12-9.
2009: Anna Maria Di Giacomo; Riccardo Danielli; Massimo Guidoboni; Luana Calabrò; Dora Carlucci; Clelia Miracco; Luca Volterrani; Maria Antonietta Mazzei; Maurizio Biagioli; Maresa Altomonte; Michele Maio
Therapeutic efficacy of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with metastatic melanoma unresponsive to prior systemic treatments: clinical and immunological evidence from three patient cases.
Cancer immunology, immunotherapy : CII 2009;58(8):1297-306.
2007: Luca Sigalotti; Elisabetta Fratta; Sandra Coral; Enzo Cortini; Alessia Covre; hugues nicolay; Lucia Anzalone; Laura Pezzani; Anna Maria Di Giacomo; Ester Fonsatti; Francesca Colizzi; Maresa Altomonte; Luana Calabrò; Michele Maio
Epigenetic drugs as pleiotropic agents in cancer treatment: biomolecular aspects and clinical applications.
Journal of cellular physiology 2007;212(2):330-44.
2007: Ester Fonsatti; hugues nicolay; Luca Sigalotti; Luana Calabrò; Laura Pezzani; Francesca Colizzi; Maresa Altomonte; Massimo Guidoboni; Francesco M Marincola; Michele Maio
Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(11):3333-8.
2007: Luana Calabrò; Anna Maria Di Giacomo; Maresa Altomonte; Ester Fonsatti; Maria Antonietta Mazzei; Luca Volterrani; Clelia Miracco; Michele Maio
Primary hepatic epithelioid hemangioendothelioma progressively responsive to interferon-alpha: is there room for novel anti-angiogenetic treatments?
Journal of experimental & clinical cancer research : CR 2007;26(1):145-50.
2006: Sandra Coral; Luca Sigalotti; Francesca Colizzi; Alberto Spessotto; Gianpaolo Nardi; Enzo Cortini; Laura Pezzani; Elisabetta Fratta; Ester Fonsatti; Anna Maria Di Giacomo; Maria Rita Nicotra; Pier Giorgio Natali; Maresa Altomonte; Michele Maio
Phenotypic and functional changes of human melanoma xenografts induced by DNA hypomethylation: immunotherapeutic implications.
Journal of cellular physiology 2006;207(1):58-66.
2006: Michele Maio; Maresa Altomonte; Ester Fonsatti
Is it the primetime for endoglin (CD105) in the clinical setting?
Cardiovascular research 2006;69(4):781-3.
2005: Valter Gattei; Ester Fonsatti; Luca Sigalotti; Massimo Degan; Anna Maria Di Giacomo; Maresa Altomonte; Luana Calabrò; Michele Maio
Epigenetic immunomodulation of hematopoietic malignancies.
Seminars in oncology 2005;32(5):503-10.
2005: Luca Sigalotti; Sandra Coral; Elisabetta Fratta; Elda Lamaj; Riccardo Danielli; Anna Maria Di Giacomo; Maresa Altomonte; Michele Maio
Epigenetic modulation of solid tumors as a novel approach for cancer immunotherapy.
Seminars in oncology 2005;32(5):473-8.
2005: Luana Calabrò; Ester Fonsatti; Maresa Altomonte; Laura Pezzani; Francesca Colizzi; Paola Nanni; Valter Gattei; Luca Sigalotti; Michele Maio
Methylation-regulated expression of cancer testis antigens in primary effusion lymphoma: immunotherapeutic implications.
Journal of cellular physiology 2005;202(2):474-7.
2004: Luca Sigalotti; Elisabetta Fratta; Sandra Coral; Silvia Tanzarella; Riccardo Danielli; Francesca Colizzi; Ester Fonsatti; Catia Traversari; Maresa Altomonte; Michele Maio
Intratumor heterogeneity of cancer/testis antigens expression in human cutaneous melanoma is methylation-regulated and functionally reverted by 5-aza-2'-deoxycytidine.
Cancer research 2004;64(24):9167-71.
2004: Maresa Altomonte; Alberto Visintin; Raffaele Tecce; Antonio Leonardi; Luana Calabro; Ester Fonsatti; Carlo Pucillo; Michele Maio
Targeting of HLA-DR molecules transduces agonistic functional signals in cutaneous melanoma.
Journal of cellular physiology 2004;200(2):272-6.
2003: Ester Fonsatti; Luca Sigalotti; P Arslan; Maresa Altomonte; Michele Maio
Emerging role of endoglin (CD105) as a marker of angiogenesis with clinical potential in human malignancies.
Current cancer drug targets 2003;3(6):427-32.
2003: Maresa Altomonte; Ester Fonsatti; Alberto Visintin; Michele Maio
Targeted therapy of solid malignancies via HLA class II antigens: a new biotherapeutic approach?
Oncogene 2003;22(42):6564-9.
2003: Ester Fonsatti; Maresa Altomonte; Maria Rita Nicotra; Pier Giorgio Natali; Michele Maio
Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels.
Oncogene 2003;22(42):6557-63.
2003: Michele Maio; Sandra Coral; Elisabetta Fratta; Maresa Altomonte; Luca Sigalotti
Epigenetic targets for immune intervention in human malignancies.
Oncogene 2003;22(42):6484-8.
2003: Ester Fonsatti; Luca Sigalotti; Sandra Coral; Francesca Colizzi; Maresa Altomonte; Michele Maio
Methylation-regulated expression of HLA class I antigens in melanoma.
International journal of cancer. Journal international du cancer 2003;105(3):430-1; author reply 432-3.
2003: Luca Sigalotti; Maresa Altomonte; Francesca Colizzi; Massimo Degan; Maurizio Rupolo; Vittorina Zagonel; Antonio Pinto; Valter Gattei; Michele Maio
5-Aza-2'-deoxycytidine (decitabine) treatment of hematopoietic malignancies: a multimechanism therapeutic approach?
Blood 2003;101(11):4644-6; discussion 4645-6.
2003: Ester Fonsatti; Maresa Altomonte; P Arslan; Michele Maio
Endoglin (CD105): a target for anti-angiogenetic cancer therapy.
Current drug targets 2003;4(4):291-6.
2003: Michele Maio; Sandra Coral; Luca Sigalotti; Rossella Elisei; Cristina Romei; Guido Rossi; Enzo Cortini; Francesca Colizzi; Gianfranco Fenzi; Maresa Altomonte; Aldo Pinchera; Mario Vitale
Analysis of cancer/testis antigens in sporadic medullary thyroid carcinoma: expression and humoral response to NY-ESO-1.
The Journal of clinical endocrinology and metabolism 2003;88(2):748-54.
2003: Luana Calabrò; Ester Fonsatti; Giacomo Bellomo; Andrea Alonci; Francesca Colizzi; Luca Sigalotti; Maresa Altomonte; Caterina Musolino; Michele Maio
Differential levels of soluble endoglin (CD105) in myeloid malignancies.
Journal of cellular physiology 2003;194(2):171-5.
2002: Maresa Altomonte; Michele Maio
European approach to antibody-based immunotherapy of melanoma.
Seminars in oncology 2002;29(5):471-8.
2002: Sandra Coral; Luca Sigalotti; Maresa Altomonte; Arne Engelsberg; Francesca Colizzi; Ilaria Cattarossi; Eugene Maraskovsky; Elke Jager; Barbara Seliger; Michele Maio
5-aza-2'-deoxycytidine-induced expression of functional cancer testis antigens in human renal cell carcinoma: immunotherapeutic implications.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(8):2690-5.
2002: Luca Sigalotti; Sandra Coral; Maresa Altomonte; L Natali; Giovanni Gaudino; Paola Cacciotti; Roberta Libener; Francesca Colizzi; Giovina Vianale; Fernanda Martini; Mauro Tognon; A Jungbluth; Jonathan Cebon; Eugene Maraskovsky; Luciano Mutti; Michele Maio
Cancer testis antigens expression in mesothelioma: role of DNA methylation and bioimmunotherapeutic implications.
British journal of cancer 2002;86(6):979-82.
2002: Michele Maio; Ester Fonsatti; Elda Lamaj; Maresa Altomonte; Ilaria Cattarossi; Cristina Santantonio; Cecilia Melani; Filiberto Belli; Flavio Arienti; Mario P Colombo; Giorgio Parmiani
Vaccination of stage IV patients with allogeneic IL-4- or IL-2-gene-transduced melanoma cells generates functional antibodies against vaccinating and autologous melanoma cells.
Cancer immunology, immunotherapy : CII 2002;51(1):9-14.
2002: Chiara De Nardo; Ester Fonsatti; Luca Sigalotti; Luana Calabrò; Francesca Colizzi; Enzo Cortini; Sandra Coral; Maresa Altomonte; Michele Maio
Recombinant transmembrane CD59 (CD59-TM) confers complement resistance to GPI-anchored protein defective melanoma cells.
Journal of cellular physiology 2002;190(2):200-6.
2002: Luca Sigalotti; Sandra Coral; Gianpaolo Nardi; Alberto Spessotto; Enzo Cortini; Ilaria Cattarossi; Francesca Colizzi; Maresa Altomonte; Michele Maio
Promoter methylation controls the expression of MAGE2, 3 and 4 genes in human cutaneous melanoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2002;25(1):16-26.
2001: Ester Fonsatti; L Del Vecchio; Maresa Altomonte; Luca Sigalotti; Maria Rita Nicotra; Sandra Coral; Pier Giorgio Natali; Michele Maio
Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies.
Journal of cellular physiology 2001;188(1):1-7.
2001: Michele Maio; Maresa Altomonte; L Calabro; Ester Fonsatti
Bioimmunotherapeutic targets on angiogenetic blood vessels in solid malignangies.
Frontiers in bioscience : a journal and virtual library 2001;6():D776-84.
2001: A Gasparollo; Sandra Coral; Marina Ciullo; Antonella Prisco; Ilaria Cattarossi; Luca Sigalotti; Maresa Altomonte; John Guardiola; Michele Maio
Unbalanced expression of HLA-A and -B antigens: a specific feature of cutaneous melanoma and other non-hemopoietic malignancies reverted by IFN-gamma.
International journal of cancer. Journal international du cancer 2001;91(4):500-7.
2000: Sandra Coral; Ester Fonsatti; Luca Sigalotti; Chiara De Nardo; Alberto Visintin; Gianpaolo Nardi; Francesca Colizzi; Mario P Colombo; G Romano; Maresa Altomonte; Michele Maio
Overexpression of protectin (CD59) down-modulates the susceptibility of human melanoma cells to homologous complement.
Journal of cellular physiology 2000;185(3):317-23.
2000: Ester Fonsatti; Maresa Altomonte; Sandra Coral; Chiara De Nardo; Elda Lamaj; Luca Sigalotti; Pier Giorgio Natali; Michele Maio
Emerging role of protectin (CD59) in humoral immunotherapy of solid malignancies.
La Clinica terapeutica 2000;151(3):187-93.
2000: Ester Fonsatti; Antti Jekunen; Kalevi Kairemo; Sandra Coral; M Snellman; Maria Rita Nicotra; Pier Giorgio Natali; Maresa Altomonte; Michele Maio
Endoglin is a suitable target for efficient imaging of solid tumors: in vivo evidence in a canine mammary carcinoma model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):2037-43.
1999: Maresa Altomonte; Ester Fonsatti; Elda Lamaj; Ilaria Cattarossi; Alessandro Cattelan; Michele Maio
Differential levels of soluble intercellular adhesion molecule-1 (sICAM-1) in early breast cancer and benign breast lesions.
Breast cancer research and treatment 1999;58(1):19-23.
1999: Maresa Altomonte; Carlo Pucillo; Michele Maio
The overlooked "nonclassical" functions of major histocompatibility complex (MHC) class II antigens in immune and nonimmune cells.
Journal of cellular physiology 1999;179(3):251-6.
1999: Ester Fonsatti; Elda Lamaj; Sandra Coral; Luca Sigalotti; Gianpaolo Nardi; A Gasparollo; Mario P Colombo; Maresa Altomonte; Michele Maio
In vitro analysis of the melanoma/endothelium interaction increasing the release of soluble intercellular adhesion molecule 1 by endothelial cells.
Cancer immunology, immunotherapy : CII 1999;48(2-3):132-8.
1999: Sandra Coral; Luca Sigalotti; A Gasparollo; Ilaria Cattarossi; Alberto Visintin; Alessandro Cattelan; Maresa Altomonte; Michele Maio
Prolonged upregulation of the expression of HLA class I antigens and costimulatory molecules on melanoma cells treated with 5-aza-2'-deoxycytidine (5-AZA-CdR).
Journal of immunotherapy (Hagerstown, Md. : 1997) 1999;22(1):16-24.
1998: Michele Maio; L I Brasoveanu; Sandra Coral; Luca Sigalotti; Elda Lamaj; A Gasparollo; Alberto Visintin; Maresa Altomonte; Ester Fonsatti
Structure, distribution, and functional role of protectin (CD59) in complement-susceptibility and in immunotherapy of human malignancies (Review).
International journal of oncology 1998;13(2):305-18.
1997: L I Brasoveanu; Ester Fonsatti; Alberto Visintin; M Pavlovic; Ilaria Cattarossi; Francesca Colizzi; A Gasparollo; Sandra Coral; V Horejsi; Maresa Altomonte; Michele Maio
Melanoma cells constitutively release an anchor-positive soluble form of protectin (sCD59) that retains functional activities in homologous complement-mediated cytotoxicity.
The Journal of clinical investigation 1997;100(5):1248-55.
1997: A Leonardi; Maresa Altomonte; M Maio; Gianluca Tell; alessandra bearz; Silvestro Formisano; Carlo Pucillo
Biphasic control of NF-kappa B activation induced by the triggering of HLA-DR antigens expressed on B cells.
Cytokine 1997;9(5):295-9.
1997: Sandra Coral; Carlo Pucillo; A Leonardi; Ester Fonsatti; Maresa Altomonte; Michele Maio
Triggering of HLA-DR antigens differentially modulates tumor necrosis factor alpha release by B cells at distinct stage of maturation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(5):581-8.
1997: Ester Fonsatti; Maresa Altomonte; Sandra Coral; Ilaria Cattarossi; M R Nicotra; A Gasparollo; P G Natali; Michele Maio
Tumour-derived interleukin 1alpha (IL-1alpha) up-regulates the release of soluble intercellular adhesion molecule-1 (sICAM-1) by endothelial cells.
British journal of cancer 1997;76(10):1255-61.
1996: Ofer Merimsky; Yehuda Shoenfeld; E Baharav; Maresa Altomonte; Samario Chaitchik; Michele Maio; S Ferrone; Pnina Fishman
Melanoma-associated hypopigmentation: where are the antibodies?
American journal of clinical oncology 1996;19(6):613-8.
1996: Maresa Altomonte; R Montagner; Ester Fonsatti; F Colizzi; Ilaria Cattarossi; L I Brasoveanu; M R Nicotra; Alessandro Cattelan; P G Natali; Michele Maio
Expression and structural features of endoglin (CD105), a transforming growth factor beta1 and beta3 binding protein, in human melanoma.
British journal of cancer 1996;74(10):1586-91.
1996: Maresa Altomonte; R Montagner; Carlo Pucillo; Michele Maio
Triggering of target of an antiproliferative antibody-1 (TAPA-1/CD81) up-regulates the release of tumour necrosis factor-alpha by the EBV-B lymphoblastoid cell line JY.
Scandinavian journal of immunology 1996;43(4):367-73.
1996: L I Brasoveanu; Maresa Altomonte; Ester Fonsatti; F Colizzi; Sandra Coral; M R Nicotra; Ilaria Cattarossi; Alessandro Cattelan; P G Natali; Michele Maio
Levels of cell membrane CD59 regulate the extent of complement-mediated lysis of human melanoma cells.
Laboratory investigation; a journal of technical methods and pathology 1996;74(1):33-42.
1995: Maresa Altomonte; C Simonelli; U Tirelli; Michele Maio
Signaling by HLA class II antigens on B cells.
Immunology today 1995;16(11):548.
1995: E Baharav; Ofer Merimsky; Maresa Altomonte; Yehuda Shoenfeld; M Pavlovic; Michele Maio; S Ferrone; Pnina Fishman
Anti-tyrosinase antibodies participate in the immune response to vaccination with anti-idiotypic antibodies mimicking the high-molecular-weight melanoma-associated antigen.
Melanoma research 1995;5(5):337-43.
1995: L I Brasoveanu; Maresa Altomonte; A Gloghini; Ester Fonsatti; Sandra Coral; A Gasparollo; R Montagner; Ilaria Cattarossi; C Simonelli; Alessandro Cattelan
Expression of protectin (CD59) in human melanoma and its functional role in cell- and complement-mediated cytotoxicity.
International journal of cancer. Journal international du cancer 1995;61(4):548-56.
1993: Maresa Altomonte; Carlo Pucillo; G Damante; Michele Maio
Cross-linking of HLA class II antigens modulates the release of tumor necrosis factor-alpha by the EBV-B lymphoblastoid cell line JY.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(10):5115-22.
1993: Maresa Altomonte; A Gloghini; G Bertola; A Gasparollo; A Carbone; S Ferrone; Michele Maio
Differential expression of cell adhesion molecules CD54/CD11a and CD58/CD2 by human melanoma cells and functional role in their interaction with cytotoxic cells.
Cancer research 1993;53(14):3343-8.
1992: Maresa Altomonte; F Colizzi; G Esposito; Michele Maio
Circulating intercellular adhesion molecule 1 as a marker of disease progression in cutaneous melanoma.
The New England journal of medicine 1992;327(13):959.
1991: Michele Maio; Maresa Altomonte; R Tatake; R A Zeff; Soldano Ferrone
Reduction in susceptibility to natural killer cell-mediated lysis of human FO-1 melanoma cells after induction of HLA class I antigen expression by transfection with B2m gene.
The Journal of clinical investigation 1991;88(1):282-9.