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Eric Alton

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Disorders

Cystic Fibrosis

Procedures

Gene Therapy

Chemicals & Drugs

Devices

Gene Transfer Techniques

Living Beings

Anatomy

Physiology

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Publications

TOP 3
Davidson Heather; Wilson Abigail; Gray Robert D; Horsley Alex; Pringle Ian A; McLachlan Gerry; Nairn Angus C; Stearns Cordelia; Gibson James; Holder Emma; Jones Lisa; Doherty Ann; Coles Rebecca; Sumner-Jones Stephanie G; Wasowicz Marguerite; Manvell Michelle; Griesenbach Uta; Hyde Stephen C; Gill Deborah R; Davies Jane; Collie D David S; Alton Eric W F W; Porteous David J; Boyd A Christopher
An immunocytochemical assay to detect human CFTR expression following gene transfer.
Miller Aaron M; Munkonge Felix M; Alton Eric W F W; Dean David A
Identification of protein cofactors necessary for sequence-specific plasmid DNA nuclear import.
Munkonge Felix M; Amin Vaksha; Hyde Stephen C; Green Anne-Marie; Pringle Ian A; Gill Deborah R; Smith Joel W S; Hooley Robert P; Xenariou Stefania; Ward Malcolm A; Leeds Nicola; Leung Kit-Yi; Chan Mario; Hillery Elizabeth; Geddes Duncan M; Griesenbach Uta; Postel Edith H; Dean David A; Dunn Michael J; Alton Eric W F W
Identification and functional characterization of cytoplasmic determinants of plasmid DNA nuclear import.

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All Publications

2009: Davidson Heather; Wilson Abigail; Gray Robert D; Horsley Alex; Pringle Ian A; McLachlan Gerry; Nairn Angus C; Stearns Cordelia; Gibson James; Holder Emma; Jones Lisa; Doherty Ann; Coles Rebecca; Sumner-Jones Stephanie G; Wasowicz Marguerite; Manvell Michelle; Griesenbach Uta; Hyde Stephen C; Gill Deborah R; Davies Jane; Collie D David S; Alton Eric W F W; Porteous David J; Boyd A Christopher
An immunocytochemical assay to detect human CFTR expression following gene transfer.
Molecular and cellular probes 2009;23(6):272-80.
2009: Miller Aaron M; Munkonge Felix M; Alton Eric W F W; Dean David A
Identification of protein cofactors necessary for sequence-specific plasmid DNA nuclear import.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(11):1897-903.
2009: Munkonge Felix M; Amin Vaksha; Hyde Stephen C; Green Anne-Marie; Pringle Ian A; Gill Deborah R; Smith Joel W S; Hooley Robert P; Xenariou Stefania; Ward Malcolm A; Leeds Nicola; Leung Kit-Yi; Chan Mario; Hillery Elizabeth; Geddes Duncan M; Griesenbach Uta; Postel Edith H; Dean David A; Dunn Michael J; Alton Eric W F W
Identification and functional characterization of cytoplasmic determinants of plasmid DNA nuclear import.
The Journal of biological chemistry 2009;284(39):26978-87.
2009: Griesenbach Uta; Meng Cuixiang; Farley Raymond; Gardner Aaron; Brake Maresa A; Frankel Gad M; Gruenert Dieter C; Cheng Seng H; Scheule Ronald K; Alton Eric W F W
The role of doxorubicin in non-viral gene transfer in the lung.
Biomaterials 2009;30(10):1971-7.
2009: Griesenbach Uta; Alton Eric W F W;
Gene transfer to the lung: lessons learned from more than 2 decades of CF gene therapy.
Advanced drug delivery reviews 2009;61(2):128-39.
2008: Griesenbach Uta; Smith Stephen N; Farley Raymond; Singh Charanjit; Alton Eric W F W
Validation of nasal potential difference measurements in gut-corrected CF knockout mice.
American journal of respiratory cell and molecular biology 2008;39(4):490-6.
2008: MacGregor Gordon; Gray Robert D; Hilliard Thomas N; Imrie Margaret; Boyd A Christopher; Alton Eric W F W; Bush Andrew; Davies Jane C; Innes J Alastair; Porteous David J; Greening Andrew P
Biomarkers for cystic fibrosis lung disease: application of SELDI-TOF mass spectrometry to BAL fluid.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2008;7(5):352-8.
2008: Davies Lee A; McLachlan Gerry; Sumner-Jones Stephanie G; Ferguson David; Baker Alison; Tennant Peter; Gordon Catherine; Vrettou Christina; Baker Eilidh; Zhu Jie; Alton Eric W F W; Collie David D S; Porteous David J; Hyde Stephen C; Gill Deborah R
Enhanced lung gene expression after aerosol delivery of concentrated pDNA/PEI complexes.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(7):1283-90.
2008: Hilliard Tom N; Zhu Jie; Farley Ray; Escudero-Garcia Sara; Wainwright Brandon J; Jeffery Peter K; Griesenbach Uta; Bush Andrew; Davies Jane C; Alton Eric W F W
Nasal abnormalities in cystic fibrosis mice independent of infection and inflammation.
American journal of respiratory cell and molecular biology 2008;39(1):19-25.
2008: Hyde Stephen C; Pringle Ian A; Abdullah Syahril; Lawton Anna E; Davies Lee A; Varathalingam Anusha; Nunez-Alonso Graciela; Green Anne-Marie; Bazzani Reto P; Sumner-Jones Stephanie G; Chan Mario; Li Hongyu; Yew Nelson S; Cheng Seng H; Boyd A Christopher; Davies Jane C; Griesenbach Uta; Porteous David J; Sheppard David N; Munkonge Felix M; Alton Eric W F W; Gill Deborah R
CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.
Nature biotechnology 2008;26(5):549-51.
2008: Davies Lee A; Varathalingam Anusha; Painter Hazel; Lawton Anna E; Sumner-Jones Stephanie G; Nunez-Alonso Graciela A; Chan Mario; Munkonge Felix; Alton Eric W F W; Hyde Stephen C; Gill Deborah R
Adenovirus-mediated in utero expression of CFTR does not improve survival of CFTR knockout mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(5):812-8.
2008: Regamey Nicolas; Ochs Matthias; Hilliard Tom N; Mühlfeld Christian; Cornish Nikki; Fleming Louise; Saglani Sejal; Alton Eric W F W; Bush Andrew; Jeffery Peter K; Davies Jane C
Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis.
American journal of respiratory and critical care medicine 2008;177(8):837-43.
2008: Griesenbach Uta; Meng Cuixiang; Farley Raymond; Cheng Seng H; Scheule Ronald K; Davies Mark H; Wolstenholme-Hogg Paul C; ten Hove Willem; van der Hoeven Paul; Sinn Patrick L; McCray Paul B; Inoue Makoto; Geddes Duncan M; Hasegawa Mamoru; Frankel Gad; Wiles Siouxsie; Alton Eric W F W
In vivo imaging of gene transfer to the respiratory tract.
Biomaterials 2008;29(10):1533-40.
2008: Davies Jane C; Cunningham Steve; Alton Eric W F W; Innes J A
Lung clearance index in CF: a sensitive marker of lung disease severity.
Thorax 2008;63(2):96-7.
2008: Horsley A R; Gustafsson P M; Macleod K A; Saunders C; Greening A P; Porteous D J; Davies J C; Cunningham S; Alton E W F W; Innes J A
Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis.
Thorax 2008;63(2):135-40.
2008: Rakonczay Zoltán; Hegyi Péter; Hasegawa Mamoru; Inoue Makoto; You Jun; Iida Akihiro; Ignáth Imre; Alton Eric W F W; Griesenbach Uta; Ovári Gabriella; Vág János; Da Paula Ana C; Crawford Russell M; Varga Gábor; Amaral Margarida D; Mehta Anil; Lonovics János; Argent Barry E; Gray Michael A
CFTR gene transfer to human cystic fibrosis pancreatic duct cells using a Sendai virus vector.
Journal of cellular physiology 2008;214(2):442-55.
2008: Regamey Nicolas; Hilliard Tom N; Saglani Sejal; Zhu Jie; Balfour-Lynn Ian M; Rosenthal Marc; Jeffery Peter K; Alton Eric W F W; Bush Andrew; Davies Jane C
Endobronchial biopsy in childhood.
Chest 2008;133(1):312; author reply 313.
2008: Griesenbach Uta; Munkonge Felix M; Sumner-Jones Stephanie; Holder Emma; Smith Stephen N; Boyd A Christopher; Gill Deborah R; Hyde Stephen C; Porteous David; Alton Eric W F W;
Assessment of CFTR function after gene transfer in vitro and in vivo.
Methods in molecular biology (Clifton, N.J.) 2008;433():229-42.
2007: Davies Jane C; Alton Eric W F W; Bush Andrew
Cystic fibrosis.
BMJ (Clinical research ed.) 2007;335(7632):1255-9.
2007: Ban H; Inoue M; Griesenbach U; Munkonge F; Chan M; Iida A; Alton E W F W; Hasegawa M
Expression and maturation of Sendai virus vector-derived CFTR protein: functional and biochemical evidence using a GFP-CFTR fusion protein.
Gene therapy 2007;14(24):1688-94.
2007: Hilliard Tom N; Regamey Nicolas; Shute Janis K; Nicholson Andrew G; Alton Eric W F W; Bush Andrew; Davies Jane C
Airway remodelling in children with cystic fibrosis.
Thorax 2007;62(12):1074-80.
2007: Ferrari S; Griesenbach U; Iida A; Farley R; Wright A M; Zhu J; Munkonge F M; Smith S N; You J; Ban H; Inoue M; Chan M; Singh C; Verdon B; Argent B E; Wainwright B; Jeffery P K; Geddes D M; Porteous D J; Hyde S C; Gray M A; Hasegawa M; Alton E W F W
Sendai virus-mediated CFTR gene transfer to the airway epithelium.
Gene therapy 2007;14(19):1371-9.
2007: Regamey Nicolas; Hilliard Thomas N; Saglani Sejal; Zhu Jie; Scallan Mike; Balfour-Lynn Ian M; Rosenthal Marc; Jeffery Peter K; Alton Eric W F W; Bush Andrew; Davies Jane C
Quality, size, and composition of pediatric endobronchial biopsies in cystic fibrosis.
Chest 2007;131(6):1710-7.
2007: Xenariou S; Griesenbach U; Liang H-D; Zhu J; Farley R; Somerton L; Singh C; Jeffery P K; Ferrari S; Scheule R K; Cheng S H; Geddes D M; Blomley M; Alton E W F W
Use of ultrasound to enhance nonviral lung gene transfer in vivo.
Gene therapy 2007;14(9):768-74.
2007: Alton Eric W F W; Davies Jane C; Geddes Duncan M
Biomarkers for cystic fibrosis: are we progressing?
American journal of respiratory and critical care medicine 2007;175(8):750-1.
2007: Aziz Z A; Davies J C; Alton E W; Wells A U; Geddes D M; Hansell D M
Computed tomography and cystic fibrosis: promises and problems.
Thorax 2007;62(2):181-6.
2007: McLachlan Gerry; Baker Alison; Tennant Peter; Gordon Catherine; Vrettou Christina; Renwick Louise; Blundell Richard; Cheng Seng H; Scheule Ron K; Davies Lee; Painter Hazel; Coles Rebecca L; Lawton Anna E; Marriott Chris; Gill Deborah R; Hyde Stephen C; Griesenbach Uta; Alton Eric W F W; Boyd A Christopher; Porteous David J; Collie D David S
Optimizing aerosol gene delivery and expression in the ovine lung.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(2):348-54.
2006: Holder E; Griesenbach U; Li S; Huang L; Rogers D F; Jeffery P K; Geddes D M; Alton E W F W
Intravenously administered oligonucleotides can be delivered to conducting airway epithelium via the bronchial circulation.
Gene therapy 2006;13(23):1628-38.
2006: Xenariou S; Griesenbach U; Ferrari S; Dean P; Scheule R K; Cheng S H; Geddes D M; Plank C; Alton E W F W
Using magnetic forces to enhance non-viral gene transfer to airway epithelium in vivo.
Gene therapy 2006;13(21):1545-52.
2006: Griesenbach U; Geddes D M; Alton E W F W
Gene therapy progress and prospects: cystic fibrosis.
Gene therapy 2006;13(14):1061-7.
2006: Hillery Elizabeth; Munkonge Felix M; Xenariou Stefania; Dean David A; Alton Eric W F W
Nondisruptive, sequence-specific coupling of fluorochromes to plasmid DNA.
Analytical biochemistry 2006;352(2):169-75.
2006: Equi Amanda C; Davies Jane C; Painter Hazel; Hyde Stephen; Bush Andrew; Geddes Duncan M; Alton Eric W F W
Exploring the mechanisms of macrolides in cystic fibrosis.
Respiratory medicine 2006;100(4):687-97.
2006: Griesenbach U; Boyton R J; Somerton L; Garcia S E; Ferrari S; Owaki T; Ya-Fen Z; Geddes D M; Hasegawa M; Altmann D M; Alton E W F W
Effect of tolerance induction to immunodominant T-cell epitopes of Sendai virus on gene expression following repeat administration to lung.
Gene therapy 2006;13(5):449-56.
2006: Radke Peter W; Heinl-Green Amanda; Frass Oliver M; Post Mark J; Sato Kaori; Geddes Duncan M; Alton Eric W F W
Evaluation of the porcine ameroid constrictor model of myocardial ischemia for therapeutic angiogenesis studies.
Endothelium : journal of endothelial cell research 2006;13(1):25-33.
2006: Griesenbach Uta; Kitson Chris; Escudero Garcia Sara; Farley Raymond; Singh Charanjit; Somerton Luci; Painter Hazel; Smith Rbecca L; Gill Deborah R; Hyde Stephen C; Chow Yu-Hua; Hu Jim; Gray Mike; Edbrooke Mark; Ogilvie Varrie; MacGregor Gordon; Scheule Ronald K; Cheng Seng H; Caplen Natasha J; Alton Eric W F W
Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.
Respiratory research 2006;7():26.
2005: Griesenbach Uta; Inoue Makoto; Hasegawa Mamoru; Alton Eric W F W
Sendai virus for gene therapy and vaccination.
Current opinion in molecular therapeutics 2005;7(4):346-52.
2005: Heinl-Green Amanda; Radke Peter W; Munkonge Felix M; Frass Oliver; Zhu Jie; Vincent Karen; Geddes Duncan M; Alton Eric W F W
The efficacy of a 'master switch gene' HIF-1alpha in a porcine model of chronic myocardial ischaemia.
European heart journal 2005;26(13):1327-32.
2005: Radke Peter W; Griesenbach Uta; Kivela Antti; Vick Terry; Judd Diane; Munkonge Felix; Willis Sean; Geddes Duncan M; Yla-Herttuala Seppo; Alton Eric W F W
Vascular oligonucleotide transfer facilitated by a polymer-coated stent.
Human gene therapy 2005;16(6):734-40.
2005: Ulrich K; Stern M; Goddard M E; Williams J; Zhu J; Dewar A; Painter H A; Jeffery P K; Gill D R; Hyde S C; Geddes D M; Takata M; Alton E W F W
Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury.
American journal of physiology. Lung cellular and molecular physiology 2005;288(6):L1179-92.
2005: Davies J C; Griesenbach U; Alton Eric
Modifier genes in cystic fibrosis.
Pediatric pulmonology 2005;39(5):383-91.
2005: Davies Jane C; Davies Michael; McShane Donna; Smith Stephen; Chadwick Sharon; Jaffe Adam; Farley Raymond; Collins Louise; Bush Andrew; Scallon Michael; Pepper John; Geddes Duncan M; Alton Eric W F W
Potential difference measurements in the lower airway of children with and without cystic fibrosis.
American journal of respiratory and critical care medicine 2005;171(9):1015-9.
2005: Davies Michael G; Geddes Duncan M; Alton Eric W F W
The effect of varying tonicity on nasal epithelial ion transport in cystic fibrosis.
American journal of respiratory and critical care medicine 2005;171(7):760-3.
2005: Hollox Edward J; Davies Jane; Griesenbach Uta; Burgess Juliana; Alton Eric W F W; Armour John A L
Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis.
Journal of negative results in biomedicine 2005;4():9.
2005: Davies Jane C; Alton Eric W F W
Airway gene therapy.
Advances in genetics 2005;54():291-314.
2005: Davies Jane; Alton Eric; Griesenbach Uta
Cystic fibrosis modifier genes.
Journal of the Royal Society of Medicine 2005;98 Suppl 45():47-54.
2004: Griesenbach Uta; Geddes Duncan M; Alton Eric W F W
Advances in cystic fibrosis gene therapy.
Current opinion in pulmonary medicine 2004;10(6):542-6.
2004: Ferrari S; Griesenbach U; Shiraki-Iida T; Shu T; Hironaka T; Hou X; Williams J; Zhu J; Jeffery P K; Geddes D M; Hasegawa M; Alton E W F W
A defective nontransmissible recombinant Sendai virus mediates efficient gene transfer to airway epithelium in vivo.
Gene therapy 2004;11(22):1659-64.
2004: Griesenbach U; Geddes D M; Alton E W F W
Gene therapy for cystic fibrosis: an example for lung gene therapy.
Gene therapy 2004;11 Suppl 1():S43-50.
2004: Munkonge Felix; Alton Eric W F W; Andersson Charlotte; Davidson Heather; Dragomir Anca; Edelman Aleksander; Farley Ray; Hjelte Lena; McLachlan Gerry; Stern Myra; Roomans Godfried M
Measurement of halide efflux from cultured and primary airway epithelial cells using fluorescence indicators.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2004;3 Suppl 2():171-6.
2004: Radke P W; Heinl-Green A; Frass O M; Griesenbach U; Ferrari S; Geddes D M; Alton E W F W
Effects of intramyocardial pVEGF165 delivery on regional myocardial blood flow: evidence for a spatial 'delivery-efficacy' mismatch.
Gene therapy 2004;11(16):1249-55.
2004: McShane D; Davies J C; Wodehouse T; Bush A; Geddes D; Alton E W F W
Normal nasal mucociliary clearance in CF children: evidence against a CFTR-related defect.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;24(1):95-100.
2004: Degabriele Naomi M; Griesenbach Uta; Sato Kaori; Post Mark J; Zhu Jie; Williams John; Jeffery Peter K; Geddes Duncan M; Alton Eric W F W
Critical appraisal of the mouse model of myocardial infarction.
Experimental physiology 2004;89(4):497-505.
2004: Alton Eric W F W;
Use of nonviral vectors for cystic fibrosis gene therapy.
Proceedings of the American Thoracic Society 2004;1(4):296-301.
2003: Middleton Peter G; Pollard Katy A; Donohoo Elizabeth; Wheatley John R; Geddes Duncan M; Alton Eric W
Airway surface liquid calcium modulates chloride permeability in the cystic fibrosis airway.
American journal of respiratory and critical care medicine 2003;168(10):1223-6.
2003: Griesenbach Uta; Geddes Duncan M; Alton Eric W
Update on gene therapy for cystic fibrosis.
Current opinion in molecular therapeutics 2003;5(5):489-94.
2003: Emerson Michael; Renwick Louise; Tate Stephen; Rhind Susan; Milne Elspeth; Painter Hazel Alsop; Boyd A Christopher; McLachlan Gerry; Griesenbach Uta; Cheng Seng H; Gill Deborah R; Hyde Stephen C; Baker Alison; Alton Eric W; Porteous David J; Collie D David S
Transfection efficiency and toxicity following delivery of naked plasmid DNA and cationic lipid-DNA complexes to ovine lung segments.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(4):646-53.
2003: Stern M; Ulrich K; Geddes D M; Alton E W F W
Poly (D, L-lactide-co-glycolide)/DNA microspheres to facilitate prolonged transgene expression in airway epithelium in vitro, ex vivo and in vivo.
Gene therapy 2003;10(16):1282-8.
2003: Munkonge Felix M; Dean David A; Hillery Elizabeth; Griesenbach Uta; Alton Eric W F W
Emerging significance of plasmid DNA nuclear import in gene therapy.
Advanced drug delivery reviews 2003;55(6):749-60.
2003: Ferrari S; Griesenbach U; Geddes D M; Alton E
Immunological hurdles to lung gene therapy.
Clinical and experimental immunology 2003;132(1):1-8.
2003: McShane D; Davies J C; Davies M G; Bush A; Geddes D M; Alton E W F W
Airway surface pH in subjects with cystic fibrosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;21(1):37-42.
2002: Ferrari Stefano; Geddes Duncan M; Alton Eric W F W
Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis.
Advanced drug delivery reviews 2002;54(11):1373-93.
2002: Griesenbach U; Ferrari S; Geddes D M; Alton E W F W
Gene therapy progress and prospects: cystic fibrosis.
Gene therapy 2002;9(20):1344-50.
2002: Davies Jane C; Potter Mike; Bush Andrew; Rosenthal Mark; Geddes Duncan M; Alton Eric W F W
Bone marrow stem cells do not repopulate the healthy upper respiratory tract.
Pediatric pulmonology 2002;34(4):251-6.
2002: Griesenbach U; Cassady R L; Cain R J; duBois R M; Geddes D M; Alton E W F W
Cytoplasmic deposition of NFkappaB decoy oligonucleotides is insufficient to inhibit bleomycin-induced pulmonary inflammation.
Gene therapy 2002;9(16):1109-15.
2002: Oceandy Delvac; McMorran Brendan J; Smith Stephen N; Schreiber Rainer; Kunzelmann Karl; Alton Eric W F W; Hume David A; Wainwright Brandon J
Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities.
Human molecular genetics 2002;11(9):1059-67.
2002: Tagawa T; Manvell M; Brown N; Keller M; Perouzel E; Murray K D; Harbottle R P; Tecle M; Booy F; Brahimi-Horn M C; Coutelle C; Lemoine N R; Alton E W F W; Miller A D
Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide mu and plasmid DNA.
Gene therapy 2002;9(9):564-76.
2002: Griesenbach Uta; Cassady Robin L; Ferrari Stefano; Fukumura Masayuki; Müller Christian; Schmitt Edgar; Zhu Jie; Jeffery Peter K; Nagai Yoshiyuki; Geddes Duncan M; Hasegawa Mamoru; Alton Eric W F W
The nasal epithelium as a factory for systemic protein delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(2):98-103.
2002: Dickinson Paul; Smith Stephen N; Webb Sheila; Kilanowski Fiona M; Campbell Isla J; Taylor Martin S; Porteous David J; Willemsen Rob; de Jonge Hugo R; Farley Ray; Alton Eric W F W; Dorin Julia R
The severe G480C cystic fibrosis mutation, when replicated in the mouse, demonstrates mistrafficking, normal survival and organ-specific bioelectrics.
Human molecular genetics 2002;11(3):243-51.
2001: Davies J C; Geddes D M; Alton E W
Gene therapy for cystic fibrosis.
The journal of gene medicine 2001;3(5):409-17.
2001: Ferrari S; Kitson C; Farley R; Steel R; Marriott C; Parkins D A; Scarpa M; Wainwright B; Evans M J; Colledge W H; Geddes D M; Alton E W
Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium.
Gene therapy 2001;8(18):1380-6.
2001: Griesenbach U; Alton E W
Recent progress in gene therapy for cystic fibrosis.
Current opinion in molecular therapeutics 2001;3(4):385-9.
2001: Davies J C; Geddes D M; Alton E W
Prospects for gene therapy in lung disease.
Current opinion in pharmacology 2001;1(3):272-7.
2001: Scheid P; Kempster L; Griesenbach U; Davies J C; Dewar A; Weber P P; Colledge W H; Evans M J; Geddes D M; Alton E W
Inflammation in cystic fibrosis airways: relationship to increased bacterial adherence.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;17(1):27-35.
2000: Yonemitsu Y; Kitson C; Ferrari S; Farley R; Griesenbach U; Judd D; Steel R; Scheid P; Zhu J; Jeffery P K; Kato A; Hasan M K; Nagai Y; Masaki I; Fukumura M; Hasegawa M; Geddes D M; Alton E W
Efficient gene transfer to airway epithelium using recombinant Sendai virus.
Nature biotechnology 2000;18(9):970-3.
2000: Alton E; Kitson C
Gene therapy for cystic fibrosis.
Expert opinion on investigational drugs 2000;9(7):1523-35.
2000: Alton E; Geddes D; Gill D; Greening A; Higgins C; Hyde S; Innes J A; Porteous D; Stern M
Measure and interpretation of CF gene therapy trial results.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(1):3-4.
2000: Stern M; Ulrich K; Robinson C; Copeland J; Griesenbach U; Masse C; Cheng S; Munkonge F; Geddes D; Berthiaume Y; Alton E
Pretreatment with cationic lipid-mediated transfer of the Na+K+-ATPase pump in a mouse model in vivo augments resolution of high permeability pulmonary oedema.
Gene therapy 2000;7(11):960-6.
2000: Griesenbach U; Scheid P; Hillery E; de Martin R; Huang L; Geddes D M; Alton E W
Anti-inflammatory gene therapy directed at the airway epithelium.
Gene therapy 2000;7(4):306-13.
2000: Jaffé A; Judd D; Ratcliffe C; Cheng S H; Bush A; Geddes D M; Alton E W
Cationic lipid-mediated gene transfer to the growing murine and human airway.
Gene therapy 2000;7(4):273-8.
2000: Stern M; Geddes D M; Alton E W
Taking stock of gene therapy for cystic fibrosis.
Respiratory research 2000;1(2):78-81.
1999: Lukacs K V; Porter C D; Pardo O E; Oakley R E; Steel R M; Judd D V; Browning J E; Geddes D M; Alton E W
In vivo transfer of bacterial marker genes results in differing levels of gene expression and tumor progression in immunocompetent and immunodeficient mice.
Human gene therapy 1999;10(14):2373-9.
1999: Griesenbach U; Geddes D M; Alton E W
The pathogenic consequences of a single mutated CFTR gene.
Thorax 1999;54 Suppl 2():S19-23.
1999: Hillery E; Cheng S; Geddes D; Alton E
Effects of altering dosing on cationic liposome-mediated gene transfer to the respiratory epithelium.
Gene therapy 1999;6(7):1313-6.
1999: Kitson C; Angel B; Judd D; Rothery S; Severs N J; Dewar A; Huang L; Wadsworth S C; Cheng S H; Geddes D M; Alton E W
The extra- and intracellular barriers to lipid and adenovirus-mediated pulmonary gene transfer in native sheep airway epithelium.
Gene therapy 1999;6(4):534-46.
1999: Alton E W; Stern M; Farley R; Jaffe A; Chadwick S L; Phillips J; Davies J; Smith S N; Browning J; Davies M G; Hodson M E; Durham S R; Li D; Jeffery P K; Scallan M; Balfour R; Eastman S J; Cheng S H; Smith A E; Meeker D; Geddes D M
Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial.
Lancet 1999;353(9157):947-54.
1999: Jaffé A; Bush A; Geddes D M; Alton E W
Prospects for gene therapy in cystic fibrosis.
Archives of disease in childhood 1999;80(3):286-9.
1999: Davies J; Dewar A; Bush A; Pitt T; Gruenert D; Geddes D M; Alton E W
Reduction in the adherence of Pseudomonas aeruginosa to native cystic fibrosis epithelium with anti-asialoGM1 antibody and neuraminidase inhibition.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;13(3):565-70.
1999: Alton E W; Griesenbach U; Geddes D M
Gene therapy for asthma: inspired research or unnecessary effort?
Gene therapy 1999;6(2):155-6.
1999: Smith S N; Middleton P G; Chadwick S; Jaffe A; Bush K A; Rolleston S; Farley R; Delaney S J; Wainwright B; Geddes D M; Alton E W
The in vivo effects of milrinone on the airways of cystic fibrosis mice and human subjects.
American journal of respiratory cell and molecular biology 1999;20(1):129-34.
1998: Alton E W; Griesenbach U; Geddes D M
Milking gene therapy.
Nature medicine 1998;4(10):1121-2.
1998: Davies J C; Geddes D M; Alton E W
Prospects for gene therapy for cystic fibrosis.
Molecular medicine today 1998;4(7):292-9.
1998: Yonemitsu Y; Alton E W; Komori K; Yoshizumi T; Sugimachi K; Kaneda Y
HVJ (Sendai virus) liposome-mediated gene transfer: current status and future perspectives (review).
International journal of oncology 1998;12(6):1277-85.
1998: Stern M; Sorgi F; Hughes C; Caplen N J; Browning J E; Middleton P G; Gruenert D C; Farr S J; Huang L; Geddes D M; Alton E W
The effects of jet nebulisation on cationic liposome-mediated gene transfer in vitro.
Gene therapy 1998;5(5):583-93.
1998: Middleton P G; Alton E W
Gene therapy for cystic fibrosis: which postman, which box?
Thorax 1998;53(3):197-9.
1998: Alton E W; Geddes D M; Gill D R; Higgins C F; Hyde S C; Innes J A; Porteous D J
Towards gene therapy for cystic fibrosis: a clinical progress report.
Gene therapy 1998;5(3):291-2.
1998: Smith S N; Delaney S J; Dorin J R; Farley R; Geddes D M; Porteous D J; Wainwright B J; Alton E W
Effect of IBMX and alkaline phosphatase inhibitors on Cl- secretion in G551D cystic fibrosis mutant mice.
The American journal of physiology 1998;274(2 Pt 1):C492-9.
1998: Stern M; Caplen N J; Browning J E; Griesenbach U; Sorgi F; Huang L; Gruenert D C; Marriot C; Crystal R G; Geddes D M; Alton E W
The effect of mucolytic agents on gene transfer across a CF sputum barrier in vitro.
Gene therapy 1998;5(1):91-8.
1997: Chadwick S L; Kingston H D; Stern M; Cook R M; O'Connor B J; Lukasson M; Balfour R P; Rosenberg M; Cheng S H; Smith A E; Meeker D P; Geddes D M; Alton E W
Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG5000 formulation to the lungs of normal volunteers.
Gene therapy 1997;4(9):937-42.
1997: Alton E W; Geddes D M
Prospects for respiratory gene therapy.
British journal of hospital medicine 1997;58(1):47-9.
1997: Davies J C; Stern M; Dewar A; Caplen N J; Munkonge F M; Pitt T; Sorgi F; Huang L; Bush A; Geddes D M; Alton E W
CFTR gene transfer reduces the binding of Pseudomonas aeruginosa to cystic fibrosis respiratory epithelium.
American journal of respiratory cell and molecular biology 1997;16(6):657-63.
1997: Alton E; Smith S; Geddes D
Gene therapy for cystic fibrosis.
Lancet 1997;349(9060):1249-50.
1997: Alton E W; Geddes D
Gene therapy: the case for cystic fibrosis.
Journal of the Royal Society of Medicine 1997;90 Suppl 31():43-6.
1996: McLachlan G; Ho L P; Davidson-Smith H; Samways J; Davidson H; Stevenson B J; Carothers A D; Alton E W; Middleton P G; Smith S N; Kallmeyer G; Michaelis U; Seeber S; Naujoks K; Greening A P; Innes J A; Dorin J R; Porteous D J
Laboratory and clinical studies in support of cystic fibrosis gene therapy using pCMV-CFTR-DOTAP.
Gene therapy 1996;3(12):1113-23.
1996: Alton E W; Norris A A
Chloride transport and the actions of nedocromil sodium and cromolyn sodium in asthma.
The Journal of allergy and clinical immunology 1996;98(5 Pt 2):S102-5; discussion S105-6.
1996: Dorin J R; Farley R; Webb S; Smith S N; Farini E; Delaney S J; Wainwright B J; Alton E W; Porteous D J
A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction.
Gene therapy 1996;3(9):797-801.
1996: Alton E W
A mild variant of cystic fibrosis.
Thorax 1996;51 Suppl 2():S51-4.
1996: Middleton P G; Geddes D M; Alton E W
Trimethoprim and tetracycline inhibit airway epithelial sodium absorption.
American journal of respiratory and critical care medicine 1996;154(1):18-23.
1996: Alton E W; Kingsleigh-Smith D J; Munkonge F M; Smith S N; Lindsay A R; Gruenert D C; Jeffery P K; Norris A; Geddes D M; Williams A J
Asthma prophylaxis agents alter the function of an airway epithelial chloride channel.
American journal of respiratory cell and molecular biology 1996;14(4):380-7.
1996: Delaney S J; Alton E W; Smith S N; Lunn D P; Farley R; Lovelock P K; Thomson S A; Hume D A; Lamb D; Porteous D J; Dorin J R; Wainwright B J
Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations.
The EMBO journal 1996;15(5):955-63.
1995: Stern M; Munkonge F M; Caplen N J; Sorgi F; Huang L; Geddes D M; Alton E W
Quantitative fluorescence measurements of chloride secretion in native airway epithelium from CF and non-CF subjects.
Gene therapy 1995;2(10):766-74.
1995: Alton E; Geddes D
The prospects for gene therapy in cystic fibrosis.
Current opinion in pulmonary medicine 1995;1(6):471-7.
1995: Caplen N J; Kinrade E; Sorgi F; Gao X; Gruenert D; Geddes D; Coutelle C; Huang L; Alton E W; Williamson R
In vitro liposome-mediated DNA transfection of epithelial cell lines using the cationic liposome DC-Chol/DOPE.
Gene therapy 1995;2(9):603-13.
1995: Hart S L; Mayall E; Stern M; Munkonge F M; Frost A; Huang L; Vasilliou M; Williamson R; Alton E W; Coutelle C
The introduction of two silent mutations into a CFTR cDNA construct allows improved detection of exogenous mRNA in gene transfer experiments.
Human molecular genetics 1995;4(9):1597-602.
1995: Alton E W; Geddes D M
Gene therapy for cystic fibrosis: a clinical perspective.
Gene therapy 1995;2(2):88-95.
1995: Smith S N; Steel D M; Middleton P G; Munkonge F M; Geddes D M; Caplen N J; Porteous D J; Dorin J R; Alton E W
Bioelectric characteristics of exon 10 insertional cystic fibrosis mouse: comparison with humans.
The American journal of physiology 1995;268(2 Pt 1):C297-307.
1995: Caplen N J; Alton E W; Middleton P G; Dorin J R; Stevenson B J; Gao X; Durham S R; Jeffery P K; Hodson M E; Coutelle C
Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis.
Nature medicine 1995;1(1):39-46.
1994: Munkonge F M; Osborne L R; Geddes D M; Alton E W
Lack of inhibition by dideoxy-forskolin and verapamil of DIDS-sensitive volume-activated Cl- secretion in human squamous lung carcinoma epithelial cells.
Biochimica et biophysica acta 1994;1224(3):342-8.
1994: Middleton P G; Geddes D M; Alton E W
Protocols for in vivo measurement of the ion transport defects in cystic fibrosis nasal epithelium.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1994;7(11):2050-6.
1994: Alton E; Geddes D
A mixed message for cystic fibrosis gene therapy.
Nature genetics 1994;8(1):8-9.
1994: Dorin J R; Stevenson B J; Fleming S; Alton E W; Dickinson P; Porteous D J
Long-term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild-type Cftr gene expression.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(8):465-72.
1994: Middleton P G; Caplen N J; Gao X; Huang L; Gaya H; Geddes D M; Alton E W
Nasal application of the cationic liposome DC-Chol:DOPE does not alter ion transport, lung function or bacterial growth.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1994;7(3):442-5.
1994: Steel D M; Graham A; Geddes D M; Alton E W
Characterization and comparison of ion transport across sheep and human airway epithelium.
Epithelial cell biology 1994;3(1):24-31.
1993: Graham A; Hasani A; Alton E W; Martin G P; Marriott C; Hodson M E; Clarke S W; Geddes D M
No added benefit from nebulized amiloride in patients with cystic fibrosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(9):1243-8.
1993: Alton E W; Middleton P G; Caplen N J; Smith S N; Steel D M; Munkonge F M; Jeffery P K; Geddes D M; Hart S L; Williamson R
Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice.
Nature genetics 1993;5(2):135-42.
1993: Graham A; Steel D M; Wilson R; Cole P J; Alton E W; Geddes D M
Effects of purified Pseudomonas rhamnolipids on bioelectric properties of sheep tracheal epithelium.
Experimental lung research 1993;19(1):77-89.
1993: Rogers D F; Alton E W; Dewar A; Lethem M I; Barnes P J
Impaired stimulus-evoked mucus secretion in cystic fibrosis bronchi.
Experimental lung research 1993;19(1):37-53.
1992: Alton E W; Rogers D F; Logan-Sinclair R; Yacoub M; Barnes P J; Geddes D M
Bioelectric properties of cystic fibrosis airways obtained at heart-lung transplantation.
Thorax 1992;47(12):1010-4.
1992: Alton E; Caplen N; Geddes D; Williamson R
New treatments for cystic fibrosis.
British medical bulletin 1992;48(4):785-804.
1992: Dorin J R; Dickinson P; Alton E W; Smith S N; Geddes D M; Stevenson B J; Kimber W L; Fleming S; Clarke A R; Hooper M L
Cystic fibrosis in the mouse by targeted insertional mutagenesis.
Nature 1992;359(6392):211-5.
1992: Graham A; Alton E W; Geddes D M
Effects of 5-hydroxytryptamine and 5-hydroxytryptamine receptor agonists on ion transport across mammalian airway epithelia.
Clinical science (London, England : 1979) 1992;83(3):331-6.
1992: Smith S N; Alton E W; Geddes D M
Ion transport characteristics of the murine trachea and caecum.
Clinical science (London, England : 1979) 1992;82(6):667-72.
1992: Graham A; Steel D M; Alton E W; Geddes D M
Second-messenger regulation of sodium transport in mammalian airway epithelia.
The Journal of physiology 1992;453():475-91.
1991: Alton E W; Manning S D; Schlatter P J; Geddes D M; Williams A J
Characterization of a Ca(2+)-dependent anion channel from sheep tracheal epithelium incorporated into planar bilayers.
The Journal of physiology 1991;443():137-59.
1991: Alton E W; Khagani A; Taylor R F; Logan-Sinclair R; Yacoub M; Geddes D M
Effect of heart-lung transplantation on airway potential difference in patients with and without cystic fibrosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1991;4(1):5-9.
1990: Rogers D F; Alton E W; Aursudkij B; Boschetto P; Dewar A; Barnes P J
Effect of platelet activating factor on formation and composition of airway fluid in the guinea-pig trachea.
The Journal of physiology 1990;431():643-58.
1990: Rogers D F; Alton E W; Dewar A; Geddes D M; Barnes P J
Tracheal potential difference in the reserpine and isoproterenol rat models of cystic fibrosis.
Experimental lung research 1990;16(6):661-70.
1990: Alton E W; Currie D; Logan-Sinclair R; Warner J O; Hodson M E; Geddes D M
Nasal potential difference: a clinical diagnostic test for cystic fibrosis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1990;3(8):922-6.
1990: Nichol G M; Alton E W; Nix A; Geddes D M; Chung K F; Barnes P J
Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects.
The American review of respiratory disease 1990;142(3):576-80.

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