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Patrick De Baetselier

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Alain Beschin; Patrick De Baetselier; Jo A Van Ginderachter
Contribution of myeloid cell subsets to liver fibrosis in parasite infection.
Geert Raes; Patrick De Baetselier; Jo A Van Ginderachter
Plasticity of monocytes, macrophages and dendritic cells is reflected in distinct organs and tissues.
Steve Schoonooghe; Jo A Van Ginderachter; Patrick De Baetselier; Nick Devoogdt; Tony Lahoutte; Damya Laoui; Geert Raes
Novel applications of nanobodies for in vivo bio-imaging of inflamed tissues in inflammatory diseases and cancer.

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All Publications

2013: Alain Beschin; Patrick De Baetselier; Jo A Van Ginderachter
Contribution of myeloid cell subsets to liver fibrosis in parasite infection.
The Journal of pathology 2013;229(2):186-97.
2012: Geert Raes; Patrick De Baetselier; Jo A Van Ginderachter
Plasticity of monocytes, macrophages and dendritic cells is reflected in distinct organs and tissues.
Immunobiology 2012;217(12):1223-4.
2012: Steve Schoonooghe; Jo A Van Ginderachter; Patrick De Baetselier; Nick Devoogdt; Tony Lahoutte; Damya Laoui; Geert Raes
Novel applications of nanobodies for in vivo bio-imaging of inflamed tissues in inflammatory diseases and cancer.
Immunobiology 2012;217(12):1266-72.
2012: C Goyvaerts; Carlo Heirman; Geert Raes; J Reiser; L Robays; K Thielemans; S Van Lint; X-Y Zhang; Patrick De Baetselier; K De Groeve; J Dingemans; Karine Breckpot
Development of the Nanobody display technology to target lentiviral vectors to antigen-presenting cells.
Gene therapy 2012;19(12):1133-40.
2012: Kiavash Movahedi; Geert Raes; Steve Schoonooghe; Luc Bouwens; Karine Breckpot; Patrick De Baetselier; Nick Devoogdt; Isabelle Houbracken; Tony Lahoutte; Damya Laoui; Wim Waelput; Jo A Van Ginderachter
Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages.
Cancer research 2012;72(16):4165-77.
2012: Didier Salmon; Pierrick Uzureau; Jan Van Den Abbeele; Gilles Vanwalleghem; Sabine Bachmaier; Alain Beschin; Michael Boshart; Patrick De Baetselier; Géraldine De Muylder; Julie Denoeud; Fernando Braga Stehling Dias; Jasmin Gossmann; Markus Kador; Carsten Krumbholz; Frédéric Lhommé; Stefan Magez; Yannick Morias; Muriel Moser; Etienne Pays
Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host.
Science (New York, N.Y.) 2012;337(6093):463-6.
2012: J Van den Bossche; Patrick De Baetselier; D Laoui; Y Morias; K Movahedi; Geert Raes; Jo A Van Ginderachter
Claudin-1, claudin-2 and claudin-11 genes differentially associate with distinct types of anti-inflammatory macrophages in vitro and with parasite- and tumour-elicited macrophages in vivo.
Scandinavian journal of immunology 2012;75(6):588-98.
2012: Jan Van den Bossche; Eva Van Overmeire; Lars Vereecke; Leena Alhonen; Lea Brys; Patrick De Baetselier; Jan M C Geuns; Eleonore S Koehler; Wouter H Lamers; Yannick Morias; Sini Pirnes-Karhu; Anne Uimari; Jo A Van Ginderachter
Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes.
Journal of leukocyte biology 2012;91(5):685-99.
2012: Guy Caljon; Vicky Caveliers; Patrick De Baetselier; Gholamreza Hassanzadeh Ghassabeh; T Lahoutte; Stefan Magez; Y Michotte; Serge Muyldermans; I Smolders; Benoit Stijlemans; Jan Van Den Abbeele; Ralph Clinckers
Using microdialysis to analyse the passage of monovalent nanobodies through the blood-brain barrier.
British journal of pharmacology 2012;165(7):2341-53.
2012: Jan Van den Bossche; Patrick De Baetselier; Bernard Malissen; Alberto Mantovani; Jo A Van Ginderachter
Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs.
Blood 2012;119(7):1623-33.
2012: Guy Caljon; Stefan Magez; Serge Muyldermans; Dirk Saerens; Benoit Stijlemans; Jan Van Den Abbeele; Patrick De Baetselier
Affinity is an important determinant of the anti-trypanosome activity of nanobodies.
PLoS neglected tropical diseases 2012;6(11):e1902.
2012: Guy Caljon; Marc Coosemans; Patrick De Baetselier; Stefan Magez; Benoit Stijlemans; Karin De Ridder; Jan Van Den Abbeele
Tsetse salivary gland proteins 1 and 2 are high affinity nucleic acid binding proteins with residual nuclease activity.
PloS one 2012;7(10):e47233.
2012: Nick Devoogdt; Matthias D'Huyvetter; Sophie Hernot; Vicky Caveliers; Patrick De Baetselier; Jens De Vos; Sam Massa; Ilse Vaneycken; Catarina Xavier; Tony Lahoutte
Molecular imaging using Nanobodies: a case study.
Methods in molecular biology (Clifton, N.J.) 2012;911():559-67.
2012: Rafael Van den Bergh; Guido Vanham; Marc Vekemans; Huyen Thanh Thi Tran; Patrick De Baetselier; Eric Florence; Stephan Grzesiek; Leo Heyndrickx; Rosina Gabriel Imiru; Sébastien Morin; Hans Jürgen Sass; Geert Raes
Monocytes contribute to differential immune pressure on R5 versus X4 HIV through the adipocytokine visfatin/NAMPT.
PloS one 2012;7(4):e35074.
2012: Linda De Vooght; Benoit Stijlemans; Guy Caljon; Marc Coosemans; Patrick De Baetselier; Jan Van Den Abbeele
Expression and extracellular release of a functional anti-trypanosome Nanobody® in Sodalis glossinidius, a bacterial symbiont of the tsetse fly.
Microbial cell factories 2012;11():23.
2011: Katrien Pletinckx; Benoit Stijlemans; Vladimir Pavlovic; Alain Beschin; Carolin Brandl; Patrick De Baetselier; Susanne Kneitz; Regina Laube; Manfred B Lutz
Similar inflammatory DC maturation signatures induced by TNF or Trypanosoma brucei antigens instruct default Th2-cell responses.
European journal of immunology 2011;41(12):3479-94.
2011: T Bosschaerts; Patrick De Baetselier; Michel Hérin; Alberto Mantovani; Yannick Morias; Chiara Porta; Antonio Sica; Benoit Stijlemans; Alain Beschin
IL-10 limits production of pathogenic TNF by M1 myeloid cells through induction of nuclear NF-κB p50 member in Trypanosoma congolense infection-resistant C57BL/6 mice.
European journal of immunology 2011;41(11):3270-80.
2011: Damya Laoui; Camille Mommer; Yannick Morias; Kiavash Movahedi; Alexandros Nikolaou; Elio Schouppe; Jan Van den Bossche; Patrick De Baetselier; Eva Van Overmeire; Jo A Van Ginderachter
Mononuclear phagocyte heterogeneity in cancer: different subsets and activation states reaching out at the tumor site.
Immunobiology 2011;216(11):1192-202.
2011: Henar Cuervo; Patrick De Baetselier; Alain Beschin; Sofía Carbajosa; Núria Gironès; Néstor A Guerrero; Manuel Fresno
Myeloid-derived suppressor cells infiltrate the heart in acute Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2656-65.
2011: Benoit Stijlemans; Lea Brys; Guy Caljon; Katja Conrath; Patrick De Baetselier; Mark C Field; Stefan Magez; Senthil Kumar A Natesan; Alexandros Nikolaou; Etienne Pays; David Pérez-Morga; Dirk Saerens; Jeremy N Skepper; Serge Muyldermans
High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis.
PLoS pathogens 2011;7(6):e1002072.
2011: Damya Laoui; Camille Mommer; Yannick Morias; Kiavash Movahedi; Alexandros Nikolaou; Elio Schouppe; Jan Van den Bossche; Patrick De Baetselier; Eva Van Overmeire; Jo A Van Ginderachter
Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions.
The International journal of developmental biology 2011;55(7-9):861-7.
2011: Tom Boonefaes; Peter Brouckaert; Patrick De Baetselier; Erica Houthuys; Geert Raes; Rafael Van den Bergh; Seppe Vander Beken; Johan Grooten
Do-it-yourself: construction of a custom cDNA macroarray platform with high sensitivity and linear range.
BMC biotechnology 2011;11():97.
2010: Jo A Van Ginderachter; Alain Beschin; Patrick De Baetselier; Geert Raes
Myeloid-derived suppressor cells in parasitic infections.
European journal of immunology 2010;40(11):2976-85.
2010: Ann Vankrunkelsven; Kris De Ceulaer; Daniel Hsu; Fu-Tong Liu; Patrick De Baetselier; Benoit Stijlemans
Lack of galectin-3 alleviates trypanosomiasis-associated anemia of inflammation.
Immunobiology 2010;215(9-10):833-41.
2010: Erica Houthuys; Kiavash Movahedi; Patrick De Baetselier; Jo A Van Ginderachter; Peter Brouckaert
A method for the isolation and purification of mouse peripheral blood monocytes.
Journal of immunological methods 2010;359(1-2):1-10.
2010: Kiavash Movahedi; Damya Laoui; Conny Gysemans; Martijn Baeten; Geert Stangé; Jan Van den Bossche; Matthias Mack; Daniel Pipeleers; Peter in't Veld; Patrick De Baetselier; Jo A Van Ginderachter
Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes.
Cancer research 2010;70(14):5728-39.
2010: Ilse Vaneycken; Jochen Govaert; Cécile Vincke; Vicky Caveliers; Tony Lahoutte; Patrick De Baetselier; Geert Raes; Axel Bossuyt; Serge Muyldermans; Nick Devoogdt
In vitro analysis and in vivo tumor targeting of a humanized, grafted nanobody in mice using pinhole SPECT/micro-CT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(7):1099-106.
2010: Nick Deschacht; Kurt De Groeve; Cécile Vincke; Geert Raes; Patrick De Baetselier; Serge Muyldermans
A novel promiscuous class of camelid single-domain antibody contributes to the antigen-binding repertoire.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(10):5696-704.
2010: Kurt De Groeve; Nick Deschacht; Celine De Koninck; Vicky Caveliers; Tony Lahoutte; Nick Devoogdt; Serge Muyldermans; Patrick De Baetselier; Geert Raes
Nanobodies as tools for in vivo imaging of specific immune cell types.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(5):782-9.
2010: Benoit Stijlemans; Ann Vankrunkelsven; Lea Brys; Geert Raes; Stefan Magez; Patrick De Baetselier
Scrutinizing the mechanisms underlying the induction of anemia of inflammation through GPI-mediated modulation of macrophage activation in a model of African trypanosomiasis.
Microbes and infection / Institut Pasteur 2010;12(5):389-99.
2010: Benoit Stijlemans; Ann Vankrunkelsven; Guy Caljon; Viki Bockstal; Martin Guilliams; T Bosschaerts; Alain Beschin; Geert Raes; Stefan Magez; Patrick De Baetselier
The central role of macrophages in trypanosomiasis-associated anemia: rationale for therapeutical approaches.
Endocrine, metabolic & immune disorders drug targets 2010;10(1):71-82.
2010: T Bosschaerts; Martin Guilliams; Benoit Stijlemans; Yannick Morias; Daniel Engel; Frank Tacke; Michel Hérin; Patrick De Baetselier; Alain Beschin
Tip-DC development during parasitic infection is regulated by IL-10 and requires CCL2/CCR2, IFN-gamma and MyD88 signaling.
PLoS pathogens 2010;6(8):e1001045.
2010: Rafael Van den Bergh; Eric Florence; Erika Vlieghe; Tom Boonefaes; Johan Grooten; Erica Houthuys; Huyen Thi Thanh Tran; Youssef Gali; Patrick De Baetselier; Guido Vanham; Geert Raes
Transcriptome analysis of monocyte-HIV interactions.
Retrovirology 2010;7():53.
2010: Jan Van Den Abbeele; Guy Caljon; K De Ridder; Patrick De Baetselier; Marc Coosemans
Trypanosoma brucei modifies the tsetse salivary composition, altering the fly feeding behavior that favors parasite transmission.
PLoS pathogens 2010;6(6):e1000926.
2010: Guy Caljon; K De Ridder; Patrick De Baetselier; Marc Coosemans; Jan Van Den Abbeele
Identification of a tsetse fly salivary protein with dual inhibitory action on human platelet aggregation.
PloS one 2010;5(3):e9671.
2009: Julio Gómez-Rodríguez; Benoit Stijlemans; Géraldine De Muylder; Hannelie Korf; Lea Brys; M Berberof; Ayub Darji; Etienne Pays; Patrick De Baetselier; Alain Beschin
Identification of a parasitic immunomodulatory protein triggering the development of suppressive M1 macrophages during African trypanosomiasis.
The Journal of infectious diseases 2009;200(12):1849-60.
2009: Jan Van den Bossche; Pieter Bogaert; Jolanda van Hengel; Christopher J Guérin; Geert Berx; Kiavash Movahedi; Rafael Van den Bergh; Anna Pereira-Fernandes; Jan M C Geuns; Hanspeter Pircher; Pierre Dorny; Johan Grooten; Patrick De Baetselier; Jo A Van Ginderachter
Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes.
Blood 2009;114(21):4664-74.
2009: Lieven Huang; Patrick De Baetselier; Rudi Beyaert
Targeting the EGF receptor ectodomain in the context of cancer.
Expert opinion on therapeutic targets 2009;13(11):1347-61.
2009: Chiara Porta; Monica Rimoldi; Geert Raes; Lea Brys; Pietro Ghezzi; Diana Di Liberto; Francesco Dieli; Serena Ghisletti; Gioacchino Natoli; Patrick De Baetselier; Alberto Mantovani; Antonio Sica
Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(35):14978-83.
2009: Boniface Namangala; Patrick De Baetselier; Alain Beschin
Quantitative differences in immune responses in mouse strains that differ in their susceptibility to Trypanosoma brucei brucei infection.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2009;71(7):951-6.
2009: Guy Caljon; Katleen Broos; Ine De Goeyse; K De Ridder; Jeremy M Sternberg; Marc Coosemans; Patrick De Baetselier; Yves Guisez; Jan Van Den Abbeele
Identification of a functional Antigen5-related allergen in the saliva of a blood feeding insect, the tsetse fly.
Insect biochemistry and molecular biology 2009;39(5-6):332-41.
2009: Serge Muyldermans; Toya Nath Baral; V Cortez Retamozzo; Patrick De Baetselier; Erwin De Genst; Jörg Kinne; H Leonhardt; Stefan Magez; Viet Khong Nguyen; Hilde Revets; U Rothbauer; Benoit Stijlemans; S Tillib; Ulrich Wernery; Lode Wyns; Gh Hassanzadeh-Ghassabeh; Dirk Saerens
Camelid immunoglobulins and nanobody technology.
Veterinary immunology and immunopathology 2009;128(1-3):178-83.
2009: Boniface Namangala; Patrick De Baetselier; Alain Beschin
Both type-I and type-II responses contribute to murine trypanotolerance.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2009;71(3):313-8.
2009: Martin Guilliams; Kiavash Movahedi; T Bosschaerts; Thierry VandenDriessche; Marinee Khim Chuah; Michel Hérin; Abel Acosta-Sanchez; Ling Ma; Muriel Moser; Jo A Van Ginderachter; Lea Brys; Patrick De Baetselier; Alain Beschin
IL-10 dampens TNF/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infection.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(2):1107-18.
2009: T Bosschaerts; Martin Guilliams; Benoit Stijlemans; Patrick De Baetselier; Alain Beschin
Understanding the role of monocytic cells in liver inflammation using parasite infection as a model.
Immunobiology 2009;214(9-10):737-47.
2008: L Huang; L Verstrepen; K Heyninck; Andy Wullaert; Hilde Revets; Patrick De Baetselier; Rudi Beyaert
ABINs inhibit EGF receptor-mediated NF-kappaB activation and growth of EGF receptor-overexpressing tumour cells.
Oncogene 2008;27(47):6131-40.
2008: Martin Guilliams; T Bosschaerts; Michel Hérin; Thomas Hünig; Patrizia Loi; Véronique Flamand; Patrick De Baetselier; Alain Beschin
Experimental expansion of the regulatory T cell population increases resistance to African trypanosomiasis.
The Journal of infectious diseases 2008;198(5):781-91.
2008: T Bosschaerts; Martin Guilliams; Wim Noel; Michel Hérin; Raymond F Burk; Kristina E Hill; Lea Brys; Geert Raes; Gholamreza Hassanzadeh Ghassabeh; Patrick De Baetselier; Alain Beschin
Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):6168-75.
2008: Lea Olive Tchouate Gainkam; Lieven Huang; Vicky Caveliers; Marleen Keyaerts; Sophie Hernot; Ilse Vaneycken; Christian Vanhove; Hilde Revets; Patrick De Baetselier; Tony Lahoutte
Comparison of the biodistribution and tumor targeting of two 99mTc-labeled anti-EGFR nanobodies in mice, using pinhole SPECT/micro-CT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(5):788-95.
2008: Lieven Huang; Lea Olive Tchouate Gainkam; Vicky Caveliers; Christian Vanhove; Marleen Keyaerts; Patrick De Baetselier; Axel Bossuyt; Hilde Revets; Tony Lahoutte
SPECT imaging with 99mTc-labeled EGFR-specific nanobody for in vivo monitoring of EGFR expression.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2008;10(3):167-75.
2008: Melissa A Barber; Tong Zhang; Bethany A Gagne; Jo A Van Ginderachter; Patrick De Baetselier; charles sentman
Ly49G2 receptor blockade reduces tumor burden in a leukemia model but not in a solid tumor model.
Cancer immunology, immunotherapy : CII 2008;57(5):655-62.
2008: Kiavash Movahedi; Martin Guilliams; Jan Van den Bossche; Rafael Van den Bergh; Conny Gysemans; Alain Beschin; Patrick De Baetselier; Jo A Van Ginderachter
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity.
Blood 2008;111(8):4233-44.
2008: Tatiana Gartner; Marta Romano; Vanessa Suin; Michaël Kalai; Hannelie Korf; Patrick De Baetselier; Kris Huygen
Immunogenicity and protective efficacy of a tuberculosis DNA vaccine co-expressing pro-apoptotic caspase-3.
Vaccine 2008;26(11):1458-70.
2008: Benoit Stijlemans; Ann Vankrunkelsven; Lea Brys; Stefan Magez; Patrick De Baetselier
Role of iron homeostasis in trypanosomiasis-associated anemia.
Immunobiology 2008;213(9-10):823-35.
2008: Stefan Magez; Anita Schwegmann; Robert Atkinson; Filip Claes; Michael Drennan; Patrick De Baetselier; Frank Brombacher
The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice.
PLoS pathogens 2008;4(8):e1000122.
2008: Jo A Van Ginderachter; Kiavash Movahedi; Jan Van den Bossche; Patrick De Baetselier
Macrophages, PPARs, and Cancer.
PPAR research 2008;2008():169414.
2008: Dirk Saerens; Benoit Stijlemans; Toya Nath Baral; Giang Thanh Nguyen Thi; Ulrich Wernery; Stefan Magez; Patrick De Baetselier; Serge Muyldermans; Katja Conrath
Parallel selection of multiple anti-infectome Nanobodies without access to purified antigens.
Journal of immunological methods 2008;329(1-2):138-50.
2007: Geert Raes; Gholamreza Hassanzadeh Ghassabeh; Lea Brys; Nonsikelelo Mpofu; Hendrik Verschueren; Dominique Vanhecke; Patrick De Baetselier
The metastatic T-cell hybridoma antigen/P-selectin glycoprotein ligand 1 is required for hematogenous metastasis of lymphomas.
International journal of cancer. Journal international du cancer 2007;121(12):2646-52.
2007: Cyril G Gay; Thomas L Richie; Paul-Pierre Pastoret; Isabel Minguez-Tudela; Patrick De Baetselier; Thomas Göbel; Bruno Goddeeris; Pete Kaiser; Ivan Morrison; Jose Manuel Sánchez-Vizcaíno; Kevin Anderson; Leslie W Baillie; Wendy C Brown; D Estes; Eileen Herrera; Peter L Nara; Christian F Ockenhouse; James A Roth; Marcelo B Sztein
Advances in immunology and vaccine discovery report of the United States-European Commission workshop.
Vaccine 2007;25(41):7007-11.
2007: Benoit Stijlemans; Toya Nath Baral; Martin Guilliams; Lea Brys; Johanna Korf; Michael Drennan; Jan Van Den Abbeele; Patrick De Baetselier; Stefan Magez
A glycosylphosphatidylinositol-based treatment alleviates trypanosomiasis-associated immunopathology.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):4003-14.
2007: Stefan Magez; Magdalena Radwanska; Michael Drennan; Lizette Fick; Toya Nath Baral; Nasiema Allie; Muazzam Jacobs; Sergei A Nedospasov; Frank Brombacher; Bernhard RYFFEL; Patrick De Baetselier
Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage-derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing.
The Journal of infectious diseases 2007;196(6):954-62.
2007: Martin Guilliams; Guillaume Oldenhove; Wim Noel; Michel Hérin; Lea Brys; Patrizia Loi; Véronique Flamand; Muriel Moser; Patrick De Baetselier; Alain Beschin
African trypanosomiasis: naturally occurring regulatory T cells favor trypanotolerance by limiting pathology associated with sustained type 1 inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):2748-57.
2007: Benoit Stijlemans; Martin Guilliams; Geert Raes; Alain Beschin; Stefan Magez; Patrick De Baetselier
African trypanosomosis: from immune escape and immunopathology to immune intervention.
Veterinary parasitology 2007;148(1):3-13.
2007: Geert Raes; Alain Beschin; Gholamreza Hassanzadeh Ghassabeh; Patrick De Baetselier
Alternatively activated macrophages in protozoan infections.
Current opinion in immunology 2007;19(4):454-9.
2007: Tatiana Gartner; Martijn Baeten; Samuel Otieno; Hilde Revets; Patrick De Baetselier; Kris Huygen
Mucosal prime-boost vaccination for tuberculosis based on TLR triggering OprI lipoprotein from Pseudomonas aeruginosa fused to mycolyl-transferase Ag85A.
Immunology letters 2007;111(1):26-35.
2007: Toya Nath Baral; Patrick De Baetselier; Frank Brombacher; Stefan Magez
Control of Trypanosoma evansi infection is IgM mediated and does not require a type I inflammatory response.
The Journal of infectious diseases 2007;195(10):1513-20.
2007: richard copin; Patrick De Baetselier; Yves Carlier; Jean-Jacques LETESSON; Eric Muraille
MyD88-dependent activation of B220-CD11b+LY-6C+ dendritic cells during Brucella melitensis infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):5182-91.
2006: Nick Devoogdt; Hilde Revets; Anne Kindt; Yuan Qing Liu; Patrick De Baetselier; Gholamreza Hassanzadeh Ghassabeh
The tumor-promoting effect of TNF-alpha involves the induction of secretory leukocyte protease inhibitor.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):8046-52.
2006: Martin Bilej; Radka Josková; Rafael Van den Bergh; Petra Procházková; Marcela Silerová; Paul Ameloot; Patrick De Baetselier; Alain Beschin
An invertebrate TNF functional analogue activates macrophages via lectin-saccharide interaction with ion channels.
International immunology 2006;18(12):1663-70.
2006: Toya Nath Baral; Stefan Magez; Benoit Stijlemans; Katja Conrath; Benoit Vanhollebeke; Etienne Pays; Serge Muyldermans; Patrick De Baetselier
[Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor].
Médecine sciences : M/S 2006;22(11):914-6.
2006: Guy Caljon; Jan Van Den Abbeele; Benoit Stijlemans; Marc Coosemans; Patrick De Baetselier; Stefan Magez
Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response.
Infection and immunity 2006;74(11):6324-30.
2006: Guy Caljon; Jan Van Den Abbeele; Jeremy M Sternberg; Marc Coosemans; Patrick De Baetselier; Stefan Magez
Tsetse fly saliva biases the immune response to Th2 and induces anti-vector antibodies that are a useful tool for exposure assessment.
International journal for parasitology 2006;36(9):1025-35.
2006: Petra Procházková; Marcela Silerová; Benoit Stijlemans; Marc Dieu; Petr Halada; Radka Josková; Alain Beschin; Patrick De Baetselier; Martin Bilej
Evidence for proteins involved in prophenoloxidase cascade Eisenia fetida earthworms.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 2006;176(6):581-7.
2006: Johanna E Korf; Gwenda Pynaert; KURT TOURNOY; Tom Boonefaes; Antoon Van Oosterhout; Daisy Ginneberge; Anuschka Haegeman; Jan A Verschoor; Patrick De Baetselier; Johan Grooten
Macrophage reprogramming by mycolic acid promotes a tolerogenic response in experimental asthma.
American journal of respiratory and critical care medicine 2006;174(2):152-60.
2006: Gholamreza Hassanzadeh Ghassabeh; Patrick De Baetselier; Lea Brys; Wim Noël; Jo A Van Ginderachter; Sofie Meerschaut; Alain Beschin; Frank Brombacher; Geert Raes
Identification of a common gene signature for type II cytokine-associated myeloid cells elicited in vivo in different pathologic conditions.
Blood 2006;108(2):575-83.
2006: Jo A Van Ginderachter; Sofie Meerschaut; Yuanqing Liu; Lea Brys; Kurt De Groeve; Gholamreza Hassanzadeh Ghassabeh; Geert Raes; Patrick De Baetselier
Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands reverse CTL suppression by alternatively activated (M2) macrophages in cancer.
Blood 2006;108(2):525-35.
2006: Stefan Magez; Magdalena Radwanska; Michael Drennan; Lizette Fick; Toya Nath Baral; Frank Brombacher; Patrick De Baetselier
Interferon-gamma and nitric oxide in combination with antibodies are key protective host immune factors during trypanosoma congolense Tc13 Infections.
The Journal of infectious diseases 2006;193(11):1575-83.
2006: Toya Nath Baral; Stefan Magez; Benoit Stijlemans; Katja Conrath; Benoit Vanhollebeke; Etienne Pays; Serge Muyldermans; Patrick De Baetselier
Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor.
Nature medicine 2006;12(5):580-4.
2006: Jo A Van Ginderachter; Kiavash Movahedi; Gholamreza Hassanzadeh Ghassabeh; Sofie Meerschaut; Alain Beschin; Geert Raes; Patrick De Baetselier
Classical and alternative activation of mononuclear phagocytes: picking the best of both worlds for tumor promotion.
Immunobiology 2006;211(6-8):487-501.
2006: Marcela Silerová; Petra Procházková; Radka Josková; Guy Josens; Alain Beschin; Patrick De Baetselier; Martin Bilej
Comparative study of the CCF-like pattern recognition protein in different Lumbricid species.
Developmental and comparative immunology 2006;30(9):765-71.
2006: Rafael Van den Bergh; Guido Vanham; Geert Raes; Patrick De Baetselier; Robert Colebunders
Mycobacterium-associated immune reconstitution disease: macrophages running wild?
The Lancet infectious diseases 2006;6(1):2-3; author reply 4-5.
2006: Petra Procházková; Marcela Silerová; Jürgen Felsberg; Radka Josková; Alain Beschin; Patrick De Baetselier; Martin Bilej
Relationship between hemolytic molecules in Eisenia fetida earthworms.
Developmental and comparative immunology 2006;30(4):381-92.
2005: Michael Drennan; Benoit Stijlemans; Jan Van Den Abbeele; Valerie QUESNIAUX; Mark Barkhuizen; Frank Brombacher; Patrick De Baetselier; Bernhard RYFFEL; Stefan Magez
The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2501-9.
2005: Geert Raes; Rafaël Van den Bergh; Patrick De Baetselier; Gholamreza Hassanzadeh Ghassabeh; Chris Scotton; Massimo Locati; Alberto Mantovani; Silvano Sozzani
Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):6561; author reply 6561-2.
2005: Lea Brys; Alain Beschin; Geert Raes; Gholamreza Hassanzadeh Ghassabeh; Wim Noël; Jef Brandt; Frank Brombacher; Patrick De Baetselier
Reactive oxygen species and 12/15-lipoxygenase contribute to the antiproliferative capacity of alternatively activated myeloid cells elicited during helminth infection.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6095-104.
2005: Johanna Korf; Anton Stoltz; Jan Verschoor; Patrick De Baetselier; Johan Grooten
The Mycobacterium tuberculosis cell wall component mycolic acid elicits pathogen-associated host innate immune responses.
European journal of immunology 2005;35(3):890-900.
2005: Geert Raes; Lea Brys; Bhola K Dahal; Jef Brandt; Johan Grooten; Frank Brombacher; Guido Vanham; Wim Noël; Pieter Bogaert; Tom Boonefaes; Anne Kindt; Rafaël Van den Bergh; Pieter J M Leenen; Patrick De Baetselier; Gholamreza Hassanzadeh Ghassabeh
Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation.
Journal of leukocyte biology 2005;77(3):321-7.
2005: Hilde Revets; Gwenda Pynaert; Johan Grooten; Patrick De Baetselier
Lipoprotein I, a TLR2/4 ligand modulates Th2-driven allergic immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(2):1097-103.
2005: Hilde Revets; Patrick De Baetselier; Serge Muyldermans
Nanobodies as novel agents for cancer therapy.
Expert opinion on biological therapy 2005;5(1):111-24.
2004: Nick Devoogdt; Hilde Revets; Gholamreza Hassanzadeh Ghassabeh; Patrick De Baetselier
Secretory leukocyte protease inhibitor in cancer development.
Annals of the New York Academy of Sciences 2004;1028():380-9.
2004: Petra Köhlerová; Alain Beschin; Marcela Silerová; Patrick De Baetselier; Martin Bilej
Effect of experimental microbial challenge on the expression of defense molecules in Eisenia foetida earthworm.
Developmental and comparative immunology 2004;28(7-8):701-11.
2004: Virna Cortez-Retamozo; Natalija Backmann; Peter D Senter; Ullrich Wernery; Patrick De Baetselier; Serge Muyldermans; Hilde Revets
Efficient cancer therapy with a nanobody-based conjugate.
Cancer research 2004;64(8):2853-7.
2004: Wim Noël; Geert Raes; Gholamreza Hassanzadeh Ghassabeh; Patrick De Baetselier; Alain Beschin
Alternatively activated macrophages during parasite infections.
Trends in parasitology 2004;20(3):126-33.
2004: Stefan Magez; Carine Truyens; Makram Merimi; Magdalena Radwanska; Benoit Stijlemans; Peter Brouckaert; Frank Brombacher; Etienne Pays; Patrick De Baetselier
P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis.
The Journal of infectious diseases 2004;189(3):527-39.
2004: Benoit Stijlemans; Katja Conrath; Virna Cortez-Retamozo; Huang Van Xong; Lode Wyns; Peter D Senter; Hilde Revets; Patrick De Baetselier; Serge Muyldermans; Stefan Magez
Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm.
The Journal of biological chemistry 2004;279(2):1256-61.
2004: Alain Beschin; Martin Bilej; Stefan Magez; Rudolf Lucas; Patrick De Baetselier
Functional convergence of invertebrate and vertebrate cytokine-like molecules based on a similar lectin-like activity.
Progress in molecular and subcellular biology 2004;34():145-63.
2003: Nadia Elia; Maxime Tapponnier; Michael A Matthay; Jürg Hamacher; Jean-Claude Pache; Marie-Anne Brundler; Martin Totsch; Patrick De Baetselier; Lucie Fransen; Norimasa Fukuda; Denis R Morel; Rudolf Lucas
Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha.
American journal of respiratory and critical care medicine 2003;168(9):1043-50.
2003: Anja B Geldhof; Jo A Van Ginderachter; Yuanqing Liu; Wim Noël; Patrick De Baetselier
Ablation of NK cell function during tumor growth favors Type 2-associated macrophages, leading to suppressed CTL generation.
Clinical & developmental immunology 2003;10(2-4):71-81.
2003: Kurt De Meyer; Patrick De Baetselier; Hendrik Verschueren; Anja B Geldhof
Morphometric analysis of cytolysis in cultured cell monolayers: a simple and versatile method for the evaluation of the lytic activity and the fate of LAK cells.
Journal of immunological methods 2003;277(1-2):193-211.
2003: Yuanqing Liu; Jo A Van Ginderachter; Lea Brys; Patrick De Baetselier; Geert Raes; Anja B Geldhof
Nitric oxide-independent CTL suppression during tumor progression: association with arginase-producing (M2) myeloid cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):5064-74.
2003: Nick Devoogdt; Gholamreza Hassanzadeh Ghassabeh; Jing Zhang; Lea Brys; Patrick De Baetselier; Hilde Revets
Secretory leukocyte protease inhibitor promotes the tumorigenic and metastatic potential of cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5778-82.
2003: Eric Muraille; Carl De Trez; Bernard Pajak; Fabiola Aguilar Torrentera; Patrick De Baetselier; Oberdan Leo; Yves Carlier
Amastigote load and cell surface phenotype of infected cells from lesions and lymph nodes of susceptible and resistant mice infected with Leishmania major.
Infection and immunity 2003;71(5):2704-15.
2003: Eric Muraille; Carl De Trez; Maryse Brait; Patrick De Baetselier; Oberdan Leo; Yves Carlier
Genetically resistant mice lacking MyD88-adapter protein display a high susceptibility to Leishmania major infection associated with a polarized Th2 response.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4237-41.
2003: Luc Vanhamme; Françoise Paturiaux-Hanocq; Philippe Poelvoorde; Derek P Nolan; laurence lins; Jan Van Den Abbeele; Annette Pays; Patricia Tebabi; Huang Van Xong; Alain Jacquet; Nicole Moguilevsky; Marc Dieu; John P Kane; Patrick De Baetselier; Robert Brasseur; Etienne Pays
Apolipoprotein L-I is the trypanosome lytic factor of human serum.
Nature 2003;422(6927):83-7.
2002: Magdalena Radwanska; Mustapha Chamekh; Luc Vanhamme; Filip Claes; Stefan Magez; Eddy Magnus; Patrick De Baetselier; Philippe Büscher; Etienne Pays
The serum resistance-associated gene as a diagnostic tool for the detection of Trypanosoma brucei rhodesiense.
The American journal of tropical medicine and hygiene 2002;67(6):684-90.
2002: Anja B Geldhof; Jo A Van Ginderachter; YuanQing Liu; Wim Noël; Geert Raes; Patrick De Baetselier
Antagonistic effect of NK cells on alternatively activated monocytes: a contribution of NK cells to CTL generation.
Blood 2002;100(12):4049-58.
2002: Hoang Van Xong; Patrick De Baetselier; Etienne Pays; Stefan Magez
Selective pressure can influence the resistance of Trypanosoma congolense to normal human serum.
Experimental parasitology 2002;102(2):61-5.
2002: Alain Beschin; Patrick De Baetselier; Martin Bilej
CCF, an invertebrate analogue of TNF, is not related to the other lytic components from Eisenia foetida earthworm.
BioEssays : news and reviews in molecular, cellular and developmental biology 2002;24(10):974; author reply 975-6.
2002: Geert Raes; Wim Noël; Alain Beschin; Lea Brys; Patrick De Baetselier; G H G Hassanzadeh
FIZZ1 and Ym as tools to discriminate between differentially activated macrophages.
Developmental immunology 2002;9(3):151-9.
2002: Stefan Magez; Benoit Stijlemans; Toya Nath Baral; Patrick De Baetselier
VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology.
Microbes and infection / Institut Pasteur 2002;4(9):999-1006.
2002: Paul Ameloot; Walter Fiers; Wim A Buurman; Patrick De Baetselier; Peter Brouckaert
Characterization of the interaction between murine tumour necrosis factor and monoclonal antibodies.
Cytokine 2002;18(3):158-63.
2002: Geert Raes; Patrick De Baetselier; Wim Noël; Alain Beschin; Frank Brombacher; Gholamreza Hassanzadeh Gh
Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages.
Journal of leukocyte biology 2002;71(4):597-602.
2002: Virna Cortez-Retamozo; Marc Lauwereys; Gholamreza Hassanzadeh Gh; Martine Gobert; Katja Conrath; Serge Muyldermans; Patrick De Baetselier; Hilde Revets
Efficient tumor targeting by single-domain antibody fragments of camels.
International journal of cancer. Journal international du cancer 2002;98(3):456-62.
2002: Stefan Magez; Benoit Stijlemans; Guy Caljon; H-P Eugster; Patrick De Baetselier
Control of experimental Trypanosoma brucei infections occurs independently of lymphotoxin-alpha induction.
Infection and immunity 2002;70(3):1342-51.
2002: Anja B Geldhof; Kurt De Meyer; Patrick De Baetselier; Hendrik Verschueren
Morphometric analysis of cytolysis in cultured cell monolayers: a simple and versatile method for the evaluation of the cytotoxic activity and the fate of LAK cells.
Laboratory investigation; a journal of technical methods and pathology 2002;82(1):105-7.
2002: Javier Cote-Sierra; Amin Bredan; Carmen M Toldos; Benoit Stijlemans; Lea Brys; Pierre Cornelis; Manuel Segovia; Patrick De Baetselier; Hilde Revets
Bacterial lipoprotein-based vaccines induce tumor necrosis factor-dependent type 1 protective immunity against Leishmania major.
Infection and immunity 2002;70(1):240-8.
2002: Alain Bloc; Rudolf Lucas; Els Van Dijck; Martin Bilej; Yves Dunant; Patrick De Baetselier; Alain Beschin
An invertebrate defense molecule activates membrane conductance in mammalian cells by means of its lectin-like domain.
Developmental and comparative immunology 2002;26(1):35-43.
2002: Elizabeth Olivares Fontt; Alain Beschin; Els Van Dijck; Vincent Vercruysse; Martin Bilej; Rudolf Lucas; Patrick De Baetselier; Bernard Vray
Trypanosoma cruzi is lysed by coelomic cytolytic factor-1, an invertebrate analogue of tumor necrosis factor, and induces phenoloxidase activity in the coelomic fluid of Eisenia foetida foetida.
Developmental and comparative immunology 2002;26(1):27-34.
2001: Martin Bilej; Patrick De Baetselier; Els Van Dijck; Benoit Stijlemans; Alain Colige; Alain Beschin
Distinct carbohydrate recognition domains of an invertebrate defense molecule recognize Gram-negative and Gram-positive bacteria.
The Journal of biological chemistry 2001;276(49):45840-7.
2001: Stefan Magez; Magdalena Radwanska; Benoit Stijlemans; Hoang Van Xong; Etienne Pays; Patrick De Baetselier
A conserved flagellar pocket exposed high mannose moiety is used by African trypanosomes as a host cytokine binding molecule.
The Journal of biological chemistry 2001;276(36):33458-64.
2001: Boniface Namangala; Wim Noël; Patrick De Baetselier; Lea Brys; Alain Beschin
Relative contribution of interferon-gamma and interleukin-10 to resistance to murine African trypanosomosis.
The Journal of infectious diseases 2001;183(12):1794-800.
2001: Alain Beschin; Martin Bilej; E Torreele; Patrick De Baetselier
On the existence of cytokines in invertebrates.
Cellular and molecular life sciences : CMLS 2001;58(5-6):801-14.
2001: E Baus; Fabienne Andris; Joelle Dewit; I Van der Taelen; Patrick De Baetselier; Jacques Urbain; Oberdan Leo; Hendrik Verschueren
Dexamethasone inhibits invasion of murine T cells through cultured fibroblastic monolayers.
International immunopharmacology 2001;1(4):785-93.
2001: Boniface Namangala; Patrick De Baetselier; Wim Noël; Lea Brys; Alain Beschin
Alternative versus classical macrophage activation during experimental African trypanosomosis.
Journal of leukocyte biology 2001;69(3):387-96.
2001: Rudolf Lucas; R Montesano; Michael S Pepper; M Hafner; E Sablon; Yves Dunant; Georges E Grau; Patrick De Baetselier; Daniela N Männel; L Fransen
Lectin-deficient TNF mutants display comparable anti-tumour but reduced pro-metastatic potential as compared to the wild-type molecule.
International journal of cancer. Journal international du cancer 2001;91(4):543-9.
2000: Jo A Van Ginderachter; Y Liu; Anja B Geldhof; L Brijs; Kris Thielemans; Patrick De Baetselier; Geert Raes
B7-1, IFN gamma and anti-CTLA-4 co-operate to prevent T-cell tolerization during immunotherapy against a murine T-lymphoma.
International journal of cancer. Journal international du cancer 2000;87(4):539-47.
2000: Boniface Namangala; Lea Brys; Stefan Magez; Patrick De Baetselier; Alain Beschin
Trypanosoma brucei brucei infection impairs MHC class II antigen presentation capacity of macrophages.
Parasite immunology 2000;22(7):361-70.
2000: Boniface Namangala; Patrick De Baetselier; L Brijs; Benoit Stijlemans; Wim Noël; Etienne Pays; M Carrington; Alain Beschin
Attenuation of Trypanosoma brucei is associated with reduced immunosuppression and concomitant production of Th2 lymphokines.
The Journal of infectious diseases 2000;181(3):1110-20.
2000: Martin Bilej; Patrick De Baetselier; Alain Beschin
Antimicrobial defense of the earthworm.
Folia microbiologica 2000;45(4):283-300.
1999: T Scorza; Stefan Magez; Lea Brys; Patrick De Baetselier
Hemozoin is a key factor in the induction of malaria-associated immunosuppression.
Parasite immunology 1999;21(11):545-54.
1999: F Gisou van der Goot; Jérôme Pugin; Marusa Hribar; L Fransen; Yves Dunant; Patrick De Baetselier; Alain Bloc; Rudolf Lucas
Membrane interaction of TNF is not sufficient to trigger increase in membrane conductance in mammalian cells.
FEBS letters 1999;460(1):107-11.
1999: Marusa Hribar; Alain Bloc; F Gisou van der Goot; L Fransen; Patrick De Baetselier; Georges E Grau; H Bluethmann; M A Matthay; Yves Dunant; Jérôme Pugin; Rudolf Lucas
The lectin-like domain of tumor necrosis factor-alpha increases membrane conductance in microvascular endothelial cells and peritoneal macrophages.
European journal of immunology 1999;29(10):3105-11.
1999: Alain Beschin; Martin Bilej; Lea Brys; E Torreele; Rudolf Lucas; Stefan Magez; Patrick De Baetselier
Convergent evolution of cytokines.
Nature 1999;400(6745):627-8.
1999: Stefan Magez; Magdalena Radwanska; Alain Beschin; K Sekikawa; Patrick De Baetselier
Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections.
Infection and immunity 1999;67(6):3128-32.
1999: R Hanusová; Martin Bilej; Lea Brys; Patrick De Baetselier; Alain Beschin
Identification of a coelomic mitogenic factor in Eisenia foetida earthworm.
Immunology letters 1999;65(3):203-11.
1998: Hoang Van Xong; Luc Vanhamme; Mustapha Chamekh; C E Chimfwembe; Jan Van Den Abbeele; Annette Pays; N Van Meirvenne; R Hamers; Patrick De Baetselier; Etienne Pays
A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense.
Cell 1998;95(6):839-46.
1998: Gholamreza Hassanzadeh Gh; Nick Devoogdt; Alain Ghysen; Patrick De Baetselier; Serge Muyldermans; Christine Dambly-Chaudière
The regulated expression of an intrabody produces a mutant phenotype in Drosophila.
FEBS letters 1998;437(1-2):81-6.
1998: Gholamreza Hassanzadeh Gh; K S De Silva; Christine Dambly-Chaudière; Lea Brys; Alain Ghysen; R Hamers; Serge Muyldermans; Patrick De Baetselier
Isolation and characterization of single-chain Fv genes encoding antibodies specific for Drosophila Poxn protein.
FEBS letters 1998;437(1-2):75-80.
1998: Javier Cote-Sierra; Erik Jongert; A Bredan; D C Gautam; M Parkhouse; Pierre Cornelis; Patrick De Baetselier; Hilde Revets
A new membrane-bound OprI lipoprotein expression vector. High production of heterologous fusion proteins in gram (-) bacteria and the implications for oral vaccination.
Gene 1998;221(1):25-34.
1998: Alain Beschin; Martin Bilej; F Hanssens; J Raymakers; E Van Dyck; Hilde Revets; Lea Brys; J Gomez; Patrick De Baetselier; M Timmermans
Identification and cloning of a glucan- and lipopolysaccharide-binding protein from Eisenia foetida earthworm involved in the activation of prophenoloxidase cascade.
The Journal of biological chemistry 1998;273(38):24948-54.
1998: C Schmidt; L Brijs; P Cliquet; Patrick De Baetselier
Increased IL-12 P40 homodimer secretion by spleen cells during in vivo growth of the BW-19 T cell hybridoma accompanies suppression of natural immunity.
International journal of cancer. Journal international du cancer 1998;77(3):460-6.
1998: Anja B Geldhof; Jo A Van Ginderachter; P Vandersteen; Geert Raes; Patrick De Baetselier
Multiple effects of transfection with interleukin 2 and/or interferon gamma on the behavior of mouse T lymphoma cells.
Clinical & experimental metastasis 1998;16(5):447-59.
1998: E O Olivares Fontt; Patrick De Baetselier; C Heirman; Kris Thielemans; Rudolf Lucas; Bernard Vray
Effects of granulocyte-macrophage colony-stimulating factor and tumor necrosis factor alpha on Trypanosoma cruzi trypomastigotes.
Infection and immunity 1998;66(6):2722-7.
1998: L Lespagnard; P Mettens; Anouk Verheyden; N Tasiaux; Kris Thielemans; Sonja Van Meirvenne; Anja B Geldhof; Patrick De Baetselier; J Urbain; Oberdan Leo; M Moser
Dendritic cells fused with mastocytoma cells elicit therapeutic antitumor immunity.
International journal of cancer. Journal international du cancer 1998;76(2):250-8.
1998: Alain Beschin; Lea Brys; Stefan Magez; Magdalena Radwanska; Patrick De Baetselier
Trypanosoma brucei infection elicits nitric oxide-dependent and nitric oxide-independent suppressive mechanisms.
Journal of leukocyte biology 1998;63(4):429-39.
1998: Stefan Magez; Benoit Stijlemans; Magdalena Radwanska; Etienne Pays; M A Ferguson; Patrick De Baetselier
The glycosyl-inositol-phosphate and dimyristoylglycerol moieties of the glycosylphosphatidylinositol anchor of the trypanosome variant-specific surface glycoprotein are distinct macrophage-activating factors.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1949-56.
1998: Geert Raes; Jo A Van Ginderachter; Nick Devoogdt; Anja B Geldhof; Patrick De Baetselier
Effects of altered antigen processing on T-cell responses toward murine T-lymphomas.
Advances in experimental medicine and biology 1998;451():211-5.
1998: Anja B Geldhof; Muriel Moser; Patrick De Baetselier
IL-12-activated NK cells recognize B7 costimulatory molecules on tumor cells and autologous dendritic cells.
Advances in experimental medicine and biology 1998;451():203-10.
1998: Martin Bilej; Pavel Rossmann; M Sinkora; R Hanusová; Alain Beschin; Geert Raes; Patrick De Baetselier
Cellular expression of the cytolytic factor in earthworms Eisenia foetida.
Immunology letters 1998;60(1):23-9.
1998: Geert Raes; Jo A Van Ginderachter; Y Q Liu; Lea Brys; Kris Thielemans; Patrick De Baetselier; Anja B Geldhof
Active antitumor immunotherapy, with or without B7-mediated costimulation, increases tumor progression in an immunogenic murine T cell lymphoma model.
Cancer immunology, immunotherapy : CII 1998;45(5):257-65.
1998: Anja B Geldhof; Muriel Moser; L Lespagnard; Kris Thielemans; Patrick De Baetselier
Interleukin-12-activated natural killer cells recognize B7 costimulatory molecules on tumor cells and autologous dendritic cells.
Blood 1998;91(1):196-206.
1997: Hendrik Verschueren; Patrick De Baetselier; Jos De Braekeleer; Joelle Dewit; K Aktories; I Just
ADP-ribosylation of Rho-proteins with botulinum C3 exoenzyme inhibits invasion and shape changes of T-lymphoma cells.
European journal of cell biology 1997;73(2):182-7.
1997: Rudolf Lucas; Bernd Echtenacher; E Sablon; P Juillard; S Magez; Jinning Lou; Yves Donati; F Bosman; A Van de Voorde; L Fransen; Daniela N Männel; Georges E Grau; Patrick De Baetselier
Generation of a mouse tumor necrosis factor mutant with antiperitonitis and desensitization activities comparable to those of the wild type but with reduced systemic toxicity.
Infection and immunity 1997;65(6):2006-10.
1997: Stefan Magez; M Geuskens; Alain Beschin; H del Favero; Hendrik Verschueren; Rudolf Lucas; Etienne Pays; Patrick De Baetselier
Specific uptake of tumor necrosis factor-alpha is involved in growth control of Trypanosoma brucei.
The Journal of cell biology 1997;137(3):715-27.
1996: Thibaut De Smedt; Bernard Pajak; Eric Muraille; L Lespagnard; E Heinen; Patrick De Baetselier; Jacques Urbain; Oberdan Leo; Muriel Moser
Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.
The Journal of experimental medicine 1996;184(4):1413-24.
1996: Anja B Geldhof; T VandenDriessche; G Opdenakker; Patrick De Baetselier
Introduction of the interferon gamma gene into mouse T lymphoma cells with low MHC class I-expression results in selective induction of H-2Dk and concomitant enhanced metastasis.
Cancer immunology, immunotherapy : CII 1996;42(6):329-38.
1996: A Darji; Alain Beschin; M Sileghem; H Heremans; Lea Brys; Patrick De Baetselier
In vitro simulation of immunosuppression caused by Trypanosoma brucei: active involvement of gamma interferon and tumor necrosis factor in the pathway of suppression.
Infection and immunity 1996;64(6):1937-43.
1995: Geert Raes; Anja B Geldhof; T Vanden Driessche; G Opdenakker; C Sibille; Patrick De Baetselier
Immunogenization of a murine T-cell lymphoma via transfection with interferon-gamma.
Leukemia 1995;9 Suppl 1():S121-7.
1995: Anja B Geldhof; Geert Raes; Marleen Bakkus; S Devos; Kris Thielemans; Patrick De Baetselier
Expression of B7-1 by highly metastatic mouse T lymphomas induces optimal natural killer cell-mediated cytotoxicity.
Cancer research 1995;55(13):2730-3.
1995: H Verschueren; I van der Taelen; J Dewit; J De Braekeleer; Patrick De Baetselier; K Aktories; I Just
Effects of Clostridium botulinum C2 toxin and cytochalasin D on in vitro invasiveness, motility and F-actin content of a murine T-lymphoma cell line.
European journal of cell biology 1995;66(4):335-41.
1995: Martin Bilej; Lea Brys; Alain Beschin; Rudolf Lucas; E Vercauteren; R Hanusová; Patrick De Baetselier
Identification of a cytolytic protein in the coelomic fluid of Eisenia foetida earthworms.
Immunology letters 1995;45(1-2):123-8.
1994: T VandenDriessche; Anja B Geldhof; Marleen Bakkus; D Toussaint-Demylle; L Brijs; Kris Thielemans; H Verschueren; Patrick De Baetselier
Metastasis of mouse T lymphoma cells is controlled by the level of major histocompatibility complex class I H-2Dk antigens.
International journal of cancer. Journal international du cancer 1994;58(2):217-25.
1994: H Verschueren; I Van der Taelen; J Dewit; J De Braekeleer; Patrick De Baetselier
Metastatic competence of BW5147 T-lymphoma cell lines is correlated with in vitro invasiveness, motility and F-actin content.
Journal of leukocyte biology 1994;55(4):552-6.
1994: C Schmidt; H Verschueren; D Toussaint-Demylle; T van den Berg; G Kraal; Patrick De Baetselier
The role of the spleen in the organ-specific metastasis of murine BW 5147 T lymphomas.
Clinical & experimental metastasis 1994;12(2):164-74.
1994: Rudolf Lucas; Stefan Magez; Robert DeLeys; L Fransen; J P Scheerlinck; M Rampelberg; Erwin Sablon; Patrick De Baetselier
Mapping the lectin-like activity of tumor necrosis factor.
Science (New York, N.Y.) 1994;263(5148):814-7.
1994: T VandenDriessche; Marleen Bakkus; D Toussaint-Demylle; Kris Thielemans; H Verschueren; Patrick De Baetselier
Tumorigenicity of mouse T lymphoma cells is controlled by the level of major histocompatibility complex class I H-2Kk antigens.
Clinical & experimental metastasis 1994;12(1):73-83.
1994: H Verschueren; J Dewit; J De Braekeleer; V Schirrmacher; Patrick De Baetselier
Motility and invasive potency of murine T-lymphoma cells: effect of microtubule inhibitors.
Cell biology international 1994;18(1):11-9.
1994: L Brys; A Van Gyseghem; S Verhaegen; E Saman; Patrick De Baetselier
Analysis of HIV infections in human macrophage-like cell lines.
Advances in experimental medicine and biology 1994;355():183-7.
1993: Stefan Magez; Rudolf Lucas; A Darji; E B Songa; R Hamers; Patrick De Baetselier
Murine tumour necrosis factor plays a protective role during the initial phase of the experimental infection with Trypanosoma brucei brucei.
Parasite immunology 1993;15(11):635-41.
1993: H Verschueren; B Houben; J De Braekeleer; J De Wit; D Roggen; Patrick De Baetselier
Methods for computer assisted analysis of lymphoid cell shape and motility, including Fourier analysis of cell outlines.
Journal of immunological methods 1993;163(1):99-113.
1993: A Darji; M Sileghem; H Heremans; Lea Brys; Patrick De Baetselier
Inhibition of T-cell responsiveness during experimental infections with Trypanosoma brucei: active involvement of endogenous gamma interferon.
Infection and immunity 1993;61(7):3098-102.
1993: Rudolf Lucas; Stefan Magez; B Songa; A Darji; R Hamers; Patrick De Baetselier
A role for TNF during African trypanosomiasis: involvement in parasite control, immunosuppression and pathology.
Research in immunology 1993;144(5):370-6.
1993: J P Scheerlinck; Robert DeLeys; E Saman; L Brys; Anja B Geldhof; Patrick De Baetselier
Redistribution of a murine humoral immune response following removal of an immunodominant B cell epitope from a recombinant fusion protein.
Molecular immunology 1993;30(8):733-9.
1993: D De Wit; M Van Mechelen; C Zanin; J M Doutrelepont; Thierry Velu; C Gérard; Daniel Abramowicz; J P Scheerlinck; Patrick De Baetselier; Jacques Urbain
Preferential activation of Th2 cells in chronic graft-versus-host reaction.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(2):361-6.
1992: A Darji; Rudolf Lucas; Stefan Magez; E Torreele; J Palacios; M Sileghem; E Bajyana Songa; R Hamers; Patrick De Baetselier
Mechanisms underlying trypanosome-elicited immunosuppression.
Annales de la Société belge de médecine tropicale 1992;72 Suppl 1():27-38.
1991: H Verschueren; J Dewit; A Van der Wegen; J De Braekeleer; G Van Heule; D Dekegel; Patrick De Baetselier
The lymphocytosis promoting action of pertussis toxin can be mimicked in vitro. Holotoxin but not the B subunit inhibits invasion of human T lymphoma cells through fibroblast monolayers.
Journal of immunological methods 1991;144(2):231-40.
1991: M Sileghem; A Darji; Patrick De Baetselier
In vitro simulation of immunosuppression caused by Trypanosoma brucei.
Immunology 1991;73(2):246-8.
1991: J P Scheerlinck; G Burssens; L Brys; A Michel; P Hauser; Patrick De Baetselier
Differential presentation of hepatitis B S-preS(2) particles and peptides by macrophages and B-cell like antigen-presenting cells.
Immunology 1991;73(1):88-94.
1991: H Verschueren; G K De Bruyne; J Dewit; Patrick De Baetselier; M M Mareel
Metastatic T-cell hybridoma cells display target preference for invasion ('homing') in tissue culture models.
Anticancer research 1991;11(3):1029-38.
1991: S Verhaegen; H Verschueren; J Brissinck; D Van Hecke; D Dekegel; Patrick De Baetselier
Interaction of B-cell hybridomas with fibroblast or hepatocyte monolayers in vitro and their metastatic behaviour in vivo.
Clinical & experimental metastasis 1991;9(2):105-17.
1991: T Vanden Driessche; H Verschueren; S Verhaegen; D Van Hecke; Patrick De Baetselier
Experimental analysis of the metastatic phenotype of malignant leukocytes.
Anticancer research 1991;11(1):49-73.
1991: H Verschueren; Patrick De Baetselier; J Bereiter-Hahn
Dynamic morphology of metastatic mouse T-lymphoma cells invading through monolayers of 10T1/2 cells.
Cell motility and the cytoskeleton 1991;20(3):203-14.
1990: Rudolf Lucas; K Heirwegh; A Neirynck; L Remels; H Van Heuverswyn; Patrick De Baetselier
Generation and characterization of a neutralizing rat anti-rmTNF-alpha monoclonal antibody.
Immunology 1990;71(2):218-23.
1990: L Remels; L Fransen; K Huygen; Patrick De Baetselier
Poly I:C activated macrophages are tumoricidal for TNF-alpha-resistant 3LL tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(11):4477-86.
1990: D Van Hecke; H Verschueren; Patrick De Baetselier
Identification of T-cell antigens expressed by metastatic T-cell hybridomas and lymphomas.
International journal of cancer. Journal international du cancer 1990;45(4):773-82.
1990: T Vanden Driessche; H Verschueren; Patrick De Baetselier
Association between MHC class I antigen expression and malignancy of murine T lymphoma variants.
Invasion & metastasis 1990;10(2):65-85.
1990: H De Vos; H Verschueren; A Convents; Patrick De Baetselier; Georges Vauquelin
Cyclic AMP content and invasive capacity of metastatic variants of the BW-5147 murine T-cell lymphoma.
Life sciences 1990;46(7):497-505.
1989: Luc Verschaeve; H Verschueren; T VandenDriessche; D van Hecke; S Verhaegen; Patrick De Baetselier
Suggestive evidence that genes controlling invasion and metastasis of T-cell lymphomas are located on mouse chromosome 3.
Genes, chromosomes & cancer 1989;1(2):119-30.
1989: M Sileghem; A Darji; R Hamers; Patrick De Baetselier
Modulation of IL-1 production and IL-1 release during experimental trypanosome infections.
Immunology 1989;68(1):137-9.
1989: H Verschueren; D Van Hecke; E Hannecart-Pokorni; D Dekegel; Patrick De Baetselier
Dual effects of pertussis toxin on in vitro invasive behavior of metastatic lymphoma variants.
Clinical & experimental metastasis 1989;7(5):541-55.
1989: L Remels; A Neirynck; Lea Brys; E Vercauteren; Patrick De Baetselier
TNF-alpha mediated selection of macrophage-resistant gene-regulatory tumor variants.
Clinical & experimental metastasis 1989;7(5):493-506.
1989: M Sileghem; A Darji; R Hamers; M Van de Winkel; Patrick De Baetselier
Dual role of macrophages in the suppression of interleukin 2 production and interleukin 2 receptor expression in trypanosome-infected mice.
European journal of immunology 1989;19(5):829-35.
1989: S Verhaegen; H Verschueren; D Dekegel; Patrick De Baetselier
The in vitro invasive behavior of human myelomonocytic cell lines is modulated by HuIFN-gamma and pertussis toxin.
Journal of biological response modifiers 1989;8(1):97-107.
1989: M Sileghem; A Darji; L Remels; R Hamers; Patrick De Baetselier
Different mechanisms account for the suppression of interleukin 2 production and the suppression of interleukin 2 receptor expression in Trypanosoma brucei-infected mice.
European journal of immunology 1989;19(1):119-24.
1988: A M Makumyaviri; M Sileghem; Dominique Le Ray; R Hamers; Patrick De Baetselier
[Lymphocyte system and relative resistance of inbred mice to Trypanosoma brucei brucei].
Annales de l'Institut Pasteur. Immunology 1988;139(5):545-56.
1988: Patrick De Baetselier; E Roos; D van Hecke; Luc Verschaeve; Lea Brys; H Verschueren
Syngeneic in vivo passage of the murine BW 5147 lymphoma results in the expression of a stable metastatic phenotype.
International journal of cancer. Journal international du cancer 1988;41(5):720-6.
1988: H Verschueren; D Dekegel; Patrick De Baetselier
Difference in motile behavior between lymphoma variants with different invasive and metastatic capabilities.
Invasion & metastasis 1988;8(1):31-44.
1988: L Remels; L Fransen; K Huygen; Patrick De Baetselier
Immunological aspects of tumor-macrophage interactions.
Advances in experimental medicine and biology 1988;233():49-59.
1987: M Sileghem; R Hamers; Patrick De Baetselier
Experimental Trypanosoma brucei infections selectively suppress both interleukin 2 production and interleukin 2 receptor expression.
European journal of immunology 1987;17(10):1417-21.
1987: H Verschueren; D Dekegel; Patrick De Baetselier
Development of a monolayer invasion assay for the discrimination and isolation of metastatic lymphoma cells.
Invasion & metastasis 1987;7(1):1-15.
1987: M Sileghem; A M Makumyaviri; Dominique Le Ray; R Hamers; Patrick De Baetselier
Modulation of lymphokine production during experimental Trypanosoma brucei infection in inbred mouse strains.
Annales de la Société belge de médecine tropicale 1987;67(2):129-35.
1986: M Sileghem; R Hamers; Patrick De Baetselier
Active suppression of interleukin 2 secretion in mice infected with Trypanosoma brucei AnTat 1.1.E.
Parasite immunology 1986;8(6):641-9.
1984: Patrick De Baetselier; E Roos; Lea Brys; L Remels; M Feldman
Generation of invasive and metastatic variants of a non-metastatic T-cell lymphoma by in vivo fusion with normal host cells.
International journal of cancer. Journal international du cancer 1984;34(5):731-8.
1984: Patrick De Baetselier; E Roos; Lea Brys; L Remels; M Gobert; D Dekegel; S Segal; M Feldman
Nonmetastatic tumor cells acquire metastatic properties following somatic hybridization with normal cells.
Cancer metastasis reviews 1984;3(1):5-24.