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Lucia Altucci

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Chemicals & Drugs

Physiology

Anatomy

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Sergio Valente; Lucia Altucci; Rosaria Benedetti; Roberto Boggio; Donatella Del Bufalo; Salvatore Di Maro; Donatella Labella; Antonello Mai; Ciro Mercurio; Ettore Novellino; Daniela Secci; Maria Tardugno; Stefano Tomassi; Daniela Trisciuoglio; Sandro Cosconati
tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells.
Alessandra F Perna; Immacolata Sepe; Lucia Altucci; Giovanni Conzo; Diana Lanza; Diego Ingrosso
Altered folate receptor 2 expression in uraemic patients on haemodialysis: implications for folate resistance.
Paola Bontempo; Vincenzo Carafa; Cesare Formisano; Roberto Grassi; Daniela Rigano; Gian Carlo Tenore; Adriana Basile; Lucia Altucci
Antioxidant, antimicrobial and anti-proliferative activities of Solanum tuberosum L. var. Vitelotte.

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2013: Sergio Valente; Lucia Altucci; Rosaria Benedetti; Roberto Boggio; Donatella Del Bufalo; Salvatore Di Maro; Donatella Labella; Antonello Mai; Ciro Mercurio; Ettore Novellino; Daniela Secci; Maria Tardugno; Stefano Tomassi; Daniela Trisciuoglio; Sandro Cosconati
tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells.
ChemMedChem 2013;8(5):800-11.
2013: Alessandra F Perna; Immacolata Sepe; Lucia Altucci; Giovanni Conzo; Diana Lanza; Diego Ingrosso
Altered folate receptor 2 expression in uraemic patients on haemodialysis: implications for folate resistance.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2013;28(5):1214-24.
2013: Paola Bontempo; Vincenzo Carafa; Cesare Formisano; Roberto Grassi; Daniela Rigano; Gian Carlo Tenore; Adriana Basile; Lucia Altucci
Antioxidant, antimicrobial and anti-proliferative activities of Solanum tuberosum L. var. Vitelotte.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013;55():304-12.
2013: Paola Bontempo; V Carafa; G Caserta; M Conte; A Doto; Cesare Formisano; Anna Maria Molinari; Angela Nebbioso; Daniela Rigano; Vincenzo Sica; Lucia Altucci
Genista sessilifolia DC. extracts induce apoptosis across a range of cancer cell lines.
Cell proliferation 2013;46(2):183-92.
2013: Patricia García-Domínguez; Carmela Dell'aversana; Lucia Altucci; Rosana Alvarez; Angel R de Lera
Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line.
Bioorganic & medicinal chemistry letters 2013;23(6):1631-5.
2013: Vincenzo Carafa; Marco Miceli; Lucia Altucci; Angela Nebbioso
Histone deacetylase inhibitors: a patent review (2009 - 2011).
Expert opinion on therapeutic patents 2013;23(1):1-17.
2012: dante rotili; Christian Steinkühler; Domenico Tarantino; Paolo Mellini; Angela Nebbioso; Chantal Paolini; Riccardo Pezzi; Antti Poso; Lucia Altucci; Giorgia Botta; Ruggero De Maria; Manel Esteller; Mario Fraga; paola gallinari; Covadonga Huidobro; Maija Lahtela-Kakkonen; Ester Lara; Alessia Lenoci; Antonello Mai
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.
Journal of medicinal chemistry 2012;55(24):10937-47.
2012: Angela Nebbioso; Rosaria Benedetti; Vincenzo Carafa; Lucia Altucci
Trials with 'epigenetic' drugs: an update.
Molecular oncology 2012;6(6):657-82.
2012: Patricia García-Domínguez; Hinrich Gronemeyer; Ilaria Lepore; Mélanie Weiss; Rosana Alvarez; Lucia Altucci; Angel R de Lera
A DNA methyltransferase modulator inspired by peyssonenyne natural product structures.
ChemMedChem 2012;7(12):2101-12.
2012: Raquel Pereira; Santiago Pérez-Rodríguez; Fátima Rodríguez-Barrios; Mayra Stuhldreier; Hendrik G Stunnenberg; Lucia Altucci; Rosaria Benedetti; Vincenzo Carafa; Mariarosaria Conte; José García-Rodríguez; Hinrich Gronemeyer; Angela Nebbioso; Angel R de Lera
Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities.
Journal of medicinal chemistry 2012;55(22):9467-91.
2012: Sergio Valente; Ettore Novellino; Gianluca Sbardella; Maria Tardugno; Stefano Tomassi; Lucia Altucci; Sabrina Castellano; Roberta Costi; Carmela Dell'Aversana; Salvatore Di Maro; Roberto Di Santo; Ilaria Lepore; Antonello Mai
Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells.
Biochimie 2012;94(11):2308-13.
2012: dante rotili; Jörg Schemies; Christian Steinkühler; Domenico Tarantino; Ettore Novellino; Chantal Paolini; Lucia Altucci; Giorgia Botta; Vincenzo Carafa; Ruggero De Maria; Salvatore Di Maro; paola gallinari; Manfred Jung; Antonello Mai
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells.
Journal of medicinal chemistry 2012;55(18):8193-7.
2012: Cristina Cellai; Luca Guandalini; Anna Laurenzana; R Matucci; D Miniati; Angela Nebbioso; Lucia Altucci; M Balliu; V Carafa; M N Romanelli; E Torre; Francesco Paoletti
The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukaemia cells.
Journal of cellular and molecular medicine 2012;16(8):1758-65.
2012: Sara Soto; Esther Vaz; Rosana Alvarez; Lucia Altucci; Carmela Dell'Aversana; Angel R de Lera
New synthetic approach to paullones and characterization of their SIRT1 inhibitory activity.
Organic & biomolecular chemistry 2012;10(10):2101-12.
2012: Carmela Dell'aversana; Lucia Altucci
miRNA-mediated deregulation in leukemia.
Frontiers in genetics 2012;3():252.
2012: Vincenzo Carafa; Angela Nebbioso; Lucia Altucci
Sirtuins and disease: the road ahead.
Frontiers in pharmacology 2012;3():4.
2011: Rosana Alvarez; Lucia Altucci; Hinrich Gronemeyer; Angel R de Lera
Epigenetic multiple modulators.
Current topics in medicinal chemistry 2011;11(22):2749-87.
2011: Patricia García-Domínguez; Hinrich Gronemeyer; Ilaria Lepore; Rosana Alvarez; Lucia Altucci; Cathie Erb; Angel R de Lera
Total synthesis of the proposed structures of the DNA methyl transferase inhibitors peyssonenynes, and structural revision of peyssonenyne B.
Organic & biomolecular chemistry 2011;9(20):6979-87.
2011: Ciro Abbondanza; Fabiana Aceto; Lucia Altucci; enrico vittorio avvedimento; Caterina De Rosa; Nicola Medici; Bruno Moncharmont; Maria Neve Ombra; Antonio Porcellini; Giovanni Alfredo Puca; Bruno Perillo
Highlighting chromosome loops in DNA-picked chromatin (DPC).
Epigenetics : official journal of the DNA Methylation Society 2011;6(8):979-86.
2011: dante rotili; Domenico Tarantino; Angela Nebbioso; Lucia Altucci; Giorgia Botta; Vincenzo Carafa; Antonello Mai
Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile.
Bioorganic & medicinal chemistry 2011;19(12):3659-68.
2011: Ciro Milite; Alessandra Tosco; Caterina Vicidomini; Lucia Altucci; Rosaria Benedetti; Ludovic Boully; Sabrina Castellano; Carmen Ciliberti; Gianluigi Franci; Antonello Mai; Gianluca Sbardella
Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs).
Bioorganic & medicinal chemistry 2011;19(12):3690-701.
2011: José García; Hinrich Gronemeyer; Angela Nebbioso; Raquel Pereira; Fátima Rodríguez-Barrios; Lucia Altucci; Rosaria Benedetti; Gianluigi Franci; Angel R de Lera
Epigenetic profiling of the antitumor natural product psammaplin A and its analogues.
Bioorganic & medicinal chemistry 2011;19(12):3637-49.
2011: Sergio Valente; Maria Tardugno; Mariarosaria Conte; Roberto Cirilli; Andrea Perrone; Rino Ragno; Silvia Simeoni; Anna Tramontano; Silvio Massa; Angela Nebbioso; Marco Miceli; Gianluigi Franci; Gerald Brosch; Lucia Altucci; Antonello Mai
Novel cinnamyl hydroxyamides and 2-aminoanilides as histone deacetylase inhibitors: apoptotic induction and cytodifferentiation activity.
ChemMedChem 2011;6(4):698-712.
2011: Vincenzo Carafa; Angela Nebbioso; Lucia Altucci
Histone deacetylase inhibitors: recent insights from basic to clinical knowledge & patenting of anti-cancer actions.
Recent patents on anti-cancer drug discovery 2011;6(1):131-45.
2010: Giovanni Di Bernardo; Nicola Alessio; Carmela Dell'Aversana; Fiorina Casale; Diana Teti; marilena cipollaro; Lucia Altucci; Umberto Galderisi
Impact of histone deacetylase inhibitors SAHA and MS-275 on DNA repair pathways in human mesenchymal stem cells.
Journal of cellular physiology 2010;225(2):537-44.
2010: Teresa Chioccarelli; Giovanna Cacciola; Lucia Altucci; Sheena E M Lewis; Luke Simon; Giulia Ricci; Catherine Ledent; Rosaria Meccariello; Silvia Fasano; Riccardo Pierantoni; Gilda Cobellis
Cannabinoid receptor 1 influences chromatin remodeling in mouse spermatids by affecting content of transition protein 2 mRNA and histone displacement.
Endocrinology 2010;151(10):5017-29.
2010: Angela Nebbioso; Carmela Dell'Aversana; Anne Bugge; Roberta Sarno; Sergio Valente; dante rotili; Fabio Manzo; Diana Teti; Susanne Mandrup; Paolo Ciana; Adriana Maggi; Antonello Mai; Hinrich Gronemeyer; Lucia Altucci
HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation.
Journal of molecular endocrinology 2010;45(4):219-28.
2010: José A Souto; Rosaria Benedetti; Katharina Otto; Marco Miceli; Rosana Alvarez; Lucia Altucci; Angel R de Lera
New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators.
ChemMedChem 2010;5(9):1530-40.
2010: dante rotili; Domenico Tarantino; Vincenzo Carafa; Ester Lara; Sarah Meade; Giorgia Botta; Angela Nebbioso; Jörg Schemies; Manfred Jung; Aleksey G Kazantsev; Manel Esteller; Mario F Fraga; Lucia Altucci; Antonello Mai
Identification of tri- and tetracyclic pyrimidinediones as sirtuin inhibitors.
ChemMedChem 2010;5(5):674-7.
2010: Gilda Cobellis; Giulia Ricci; Giovanna Cacciola; Pierangelo Orlando; Stefania Petrosino; Maria Grazia Cascio; Tiziana Bisogno; Luciano De Petrocellis; Teresa Chioccarelli; Lucia Altucci; Silvia Fasano; Rosaria Meccariello; Riccardo Pierantoni; Catherine Ledent; Vincenzo Di Marzo
A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up.
Biology of reproduction 2010;82(2):451-8.
2010: Luisa Quinti; Vanita Chopra; dante rotili; Sergio Valente; Allison Amore; Gianluigi Franci; Sarah Meade; Marta Valenza; Lucia Altucci; Michele M Maxwell; Elena Cattaneo; Steven M Hersch; Antonello Mai; Aleksey Kazantsev
Evaluation of histone deacetylases as drug targets in Huntington's disease models. Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model.
PLoS currents 2010;2():.
2009: Hong Su; Liqin Yu; Angela Nebbioso; Vincenzo Carafa; Yadong Chen; Lucia Altucci; Qidong You
Novel N-hydroxybenzamide-based HDAC inhibitors with branched CAP group.
Bioorganic & medicinal chemistry letters 2009;19(22):6284-8.
2009: Antonello Mai; Sergio Valente; Sarah Meade; Vincenzo Carafa; Maria Tardugno; Angela Nebbioso; Andrea Galmozzi; Nico Mitro; Emma De Fabiani; Lucia Altucci; Aleksey Kazantsev
Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors.
Journal of medicinal chemistry 2009;52(17):5496-504.
2009: Pattabhiraman Shankaranarayanan; Aurélie Rossin; Harshal Khanwalkar; Susana Alvarez; Rosana Alvarez; Annica Jacobson; Angela Nebbioso; Angel R de Lera; Lucia Altucci; Hinrich Gronemeyer
Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO.
Cancer cell 2009;16(3):220-31.
2009: Sergio Valente; Mariarosaria Conte; Maria Tardugno; Silvio Massa; Angela Nebbioso; Lucia Altucci; Antonello Mai
Pyrrole-based hydroxamates and 2-aminoanilides: histone deacetylase inhibition and cellular activities.
ChemMedChem 2009;4(9):1411-5.
2009: Angela Nebbioso; Fabio Manzo; Marco Miceli; Mariarosaria Conte; Lucrezia Manente; Alfonso Baldi; Antonio De Luca; Dante Rotili; Sergio Valente; Antonello Mai; Alessandro Usiello; Hinrich Gronemeyer; Lucia Altucci
Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.
EMBO reports 2009;10(7):776-82.
2009: Fabio Manzo; Francesco Paolo Tambaro; Antonello Mai; Lucia Altucci
Histone acetyltransferase inhibitors and preclinical studies.
Expert opinion on therapeutic patents 2009;19(6):761-74.
2009: Lucia Altucci; Saverio Minucci
Epigenetic therapies in haematological malignancies: searching for true targets.
European journal of cancer (Oxford, England : 1990) 2009;45(7):1137-45.
2009: Giovanni Di Bernardo; Tiziana Squillaro; Carmela Dell'Aversana; Marco Miceli; marilena cipollaro; Antonino Cascino; Lucia Altucci; Umberto Galderisi
Histone deacetylase inhibitors promote apoptosis and senescence in human mesenchymal stem cells.
Stem cells and development 2009;18(4):573-81.
2009: Fabio Manzo; Angela Nebbioso; Marco Miceli; Mariarosaria Conte; Floriana De Bellis; Vincenzo Carafa; Gianluigi Franci; Francesco P Tambaro; Lucia Altucci
TNF-related apoptosis-inducing ligand: signalling of a 'smart' molecule.
The international journal of biochemistry & cell biology 2009;41(3):460-6.
2009: Antonello Mai; Dante Rotili; Domenico Tarantino; Angela Nebbioso; Sabrina Castellano; Gianluca Sbardella; Marc Tini; Lucia Altucci
Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases.
Bioorganic & medicinal chemistry letters 2009;19(4):1132-5.
2009: Paola Bontempo; Luigi Mita; Antonella Doto; Marco Miceli; Angela Nebbioso; Ilaria Lepore; GianLuigi Franci; Roberta Menafra; Vincenzo Carafa; Mariarosaria Conte; Floriana De Bellis; Fabio Manzo; Vincenzo Di Cerbo; Rosaria Benedetti; Loredana D'Amato; Maria Marino; Alessandro Bolli; Giovanna Del Pozzo; Nadia Diano; Marianna Portaccio; Gustavo D Mita; Maria Teresa Vietri; Michele Cioffi; Ernesto Nola; Carmela Dell'aversana; Vincenzo Sica; Anna Maria Molinari; Lucia Altucci
Molecular analysis of the apoptotic effects of BPA in acute myeloid leukemia cells.
Journal of translational medicine 2009;7():48.
2009: Lucia Altucci; Hendrik G Stunnenberg
Time for epigenetics.
The international journal of biochemistry & cell biology 2009;41(1):2-3.
2009: Antonello Mai; Sergio Valente; Angela Nebbioso; Silvia Simeoni; Rino Ragno; Silvio Massa; Gerald Brosch; Floriana De Bellis; Fabio Manzo; Lucia Altucci
New pyrrole-based histone deacetylase inhibitors: binding mode, enzyme- and cell-based investigations.
The international journal of biochemistry & cell biology 2009;41(1):235-47.
2009: Antonello Mai; Lucia Altucci
Epi-drugs to fight cancer: from chemistry to cancer treatment, the road ahead.
The international journal of biochemistry & cell biology 2009;41(1):199-213.
2008: Claudia Colussi; Chiara Mozzetta; Aymone Gurtner; Barbara Illi; Jessica Rosati; Stefania Straino; Gianluca Ragone; Mario Pescatori; Germana Zaccagnini; Annalisa Antonini; Giulia Minetti; Fabio Martelli; Giulia Piaggio; paola gallinari; Christian Steinkuhler; Christian Steinkulher; Emilio Clementi; Carmela Dell'Aversana; Lucia Altucci; Antonello Mai; Maurizio C Capogrossi; Pier Lorenzo Puri; carlo gaetano
HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19183-7.
2008: Alessandro Bolli; Paola Galluzzo; Paolo Ascenzi; Giovanna Del Pozzo; Immacolata Manco; Maria Teresa Vietri; Luigi Mita; Lucia Altucci; Damiano Gustavo Mita; Maria Marino
Laccase treatment impairs bisphenol A-induced cancer cell proliferation affecting estrogen receptor alpha-dependent rapid signals.
IUBMB life 2008;60(12):843-52.
2008: Maria Cucinotta; Maria Visalli; Mohamed Aguennouz; Andrea Valenti; Saverio Loddo; Lucia Altucci; Diana Teti
Regulation of interleukin-8 gene at a distinct site of its promoter by CCAAT enhancer-binding protein homologous protein in prostaglandin E2-treated human T cells.
The Journal of biological chemistry 2008;283(44):29760-9.
2008: Annamaria Scognamiglio; Angela Nebbioso; Fabio Manzo; Sergio Valente; Antonello Mai; Lucia Altucci
HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2.
Biochimica et biophysica acta 2008;1783(10):2030-8.
2008: Hong Su; Angela Nebbioso; Vincenzo Carafa; Yadong Chen; Bo Yang; Lucia Altucci; Qi-Dong You
Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents.
Bioorganic & medicinal chemistry 2008;16(17):7992-8002.
2008: José A Souto; Mariarosaria Conte; Rosana Alvarez; Angela Nebbioso; Vincenzo Carafa; Lucia Altucci; Angel R de Lera
Synthesis of benzamides related to anacardic acid and their histone acetyltransferase (HAT) inhibitory activities.
ChemMedChem 2008;3(9):1435-42.
2008: Hong Su; Lucia Altucci; Qi-Dong You
Competitive or noncompetitive, that's the question: research toward histone deacetylase inhibitors.
Molecular cancer therapeutics 2008;7(5):1007-12.
2008: Gianluca Sbardella; Sabrina Castellano; Caterina Vicidomini; Dante Rotili; Angela Nebbioso; Marco Miceli; Lucia Altucci; Antonello Mai
Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases.
Bioorganic & medicinal chemistry letters 2008;18(9):2788-92.
2008: Antonello Mai; Andrea Perrone; Angela Nebbioso; Dante Rotili; Sergio Valente; Maria Tardugno; Silvio Massa; Floriana De Bellis; Lucia Altucci
Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities.
Bioorganic & medicinal chemistry letters 2008;18(8):2530-5.
2008: Antonello Mai; Donghang Cheng; Mark T Bedford; Sergio Valente; Angela Nebbioso; Andrea Perrone; Gerald Brosch; Gianluca Sbardella; Floriana De Bellis; Marco Miceli; Lucia Altucci
epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors.
Journal of medicinal chemistry 2008;51(7):2279-90.
2008: Lucrezia Manente; A Perna; Elisabetta Buommino; Lucia Altucci; Antonio Lucariello; Gennaro Citro; Alfonso Baldi; Gaetano Iaquinto; Maria Antonietta Tufano; Antonio De Luca
The Helicobacter pylori's protein VacA has direct effects on the regulation of cell cycle and apoptosis in gastric epithelial cells.
Journal of cellular physiology 2008;214(3):582-7.
2008: Alessandra Verdina; Irene Cardillo; Angela Nebbioso; rossella galati; Simona Menegozzo; Lucia Altucci; Ada Sacchi; Alfonso Baldi
Molecular analysis of the effects of Piroxicam and Cisplatin on mesothelioma cells growth and viability.
Journal of translational medicine 2008;6():27.
2007: Antonello Mai; Katija Jelicic; Dante Rotili; Antonella Di Noia; Elena Alfani; Sergio Valente; Lucia Altucci; Angela Nebbioso; Silvio Massa; Renzo Galanello; Gerald Brosch; Anna Rita Migliaccio; Giovanni Migliaccio
Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia.
Molecular pharmacology 2007;72(5):1111-23.
2007: Angel R de Lera; William Bourguet; Lucia Altucci; Hinrich Gronemeyer
Design of selective nuclear receptor modulators: RAR and RXR as a case study.
Nature reviews. Drug discovery 2007;6(10):811-20.
2007: Lucia Altucci; Mark D Leibowitz; Kathleen M Ogilvie; Angel R de Lera; Hinrich Gronemeyer
RAR and RXR modulation in cancer and metabolic disease.
Nature reviews. Drug discovery 2007;6(10):793-810.
2007: Giulia Ricci; Giovanna Cacciola; Lucia Altucci; Rosaria Meccariello; Riccardo Pierantoni; Silvia Fasano; Gilda Cobellis
Endocannabinoid control of sperm motility: the role of epididymus.
General and comparative endocrinology 2007;153(1-3):320-2.
2007: Antonello Mai; Sergio Valente; Donghang Cheng; Andrea Perrone; Rino Ragno; Silvia Simeoni; Gianluca Sbardella; Gerald Brosch; Angela Nebbioso; Mariarosaria Conte; Lucia Altucci; Mark T Bedford
Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors.
ChemMedChem 2007;2(7):987-91.
2007: Carlos Pérez-Balado; Angela Nebbioso; Paula Rodríguez-Graña; Annunziata Minichiello; Marco Miceli; Lucia Altucci; Angel R de Lera
Bispyridinium dienes: histone deacetylase inhibitors with selective activities.
Journal of medicinal chemistry 2007;50(10):2497-505.
2007: Paola Bontempo; Luigi Mita; Marco Miceli; Antonella Doto; Angela Nebbioso; Floriana De Bellis; Mariarosaria Conte; Annunziata Minichiello; Fabio Manzo; Vincenzo Carafa; Adriana Basile; Daniela Rigano; Sergio Sorbo; Rosa Castaldo Cobianchi; Ettore Mariano Schiavone; Felicetto Ferrara; Mariacarla De Simone; Maria Teresa Vietri; Michele Cioffi; Vincenzo Sica; Francesco Bresciani; Angel R de Lera; Lucia Altucci; Anna Maria Molinari
Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities.
The international journal of biochemistry & cell biology 2007;39(10):1902-14.
2007: Lucia Altucci; Lodovico Balducci; Irmgard Irminger-Finger
Cancer therapy: new drugs are emerging based on molecular targeting but still many challenges.
The international journal of biochemistry & cell biology 2007;39(7-8):1278-9.
2007: Antonello Mai; Sergio Valente; Dante Rotili; Silvio Massa; Giorgia Botta; Gerald Brosch; Marco Miceli; Angela Nebbioso; Lucia Altucci
Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity.
The international journal of biochemistry & cell biology 2007;39(7-8):1510-22.
2006: Antonello Mai; Dante Rotili; Domenico Tarantino; Prisca Ornaghi; Federica Tosi; Caterina Vicidomini; Gianluca Sbardella; Angela Nebbioso; Marco Miceli; Lucia Altucci; patrizia filetici
Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties.
Journal of medicinal chemistry 2006;49(23):6897-907.
2006: Enrico P Spugnini; Irene Cardillo; Alessandra Verdina; Stefania Crispi; Silvia Saviozzi; Raffaele A Calogero; Angela Nebbioso; Lucia Altucci; Giancarlo Cortese; rossella galati; Jeremy Chien; Viji Shridhar; Bruno Vincenzi; Gennaro Citro; Francesco Cognetti; Ada Sacchi; Alfonso Baldi
Piroxicam and cisplatin in a mouse model of peritoneal mesothelioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(20 Pt 1):6133-43.
2006: Antonello Mai; Silvio Massa; Dante Rotili; Silvia Simeoni; Rino Ragno; Giorgia Botta; Angela Nebbioso; Marco Miceli; Lucia Altucci; Gerald Brosch
Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.
Journal of medicinal chemistry 2006;49(20):6046-56.
2006: Claudio Scafoglio; Concetta Ambrosino; Luigi Cicatiello; Lucia Altucci; Mario Ardovino; Paola Bontempo; Nicola Medici; Anna Maria Molinari; Angela Nebbioso; Angelo Facchiano; Raffaele A Calogero; Ran Elkon; Nadia Menini; Riccardo Ponzone; Nicoletta Biglia; Piero Sismondi; Michele De Bortoli; Alessandro Weisz
Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells.
Journal of cellular biochemistry 2006;98(5):1163-84.
2005: Lucia Altucci; Aurélie Rossin; Oliver Hirsch; Angela Nebbioso; Dominique VITOUX; Emmanuelle Wilhelm; Fabien Guidez; Mariacarla De Simone; Ettore Mariano Schiavone; David Grimwade; Arthur Zelent; Hugues de Thé; Hinrich Gronemeyer
Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor.
Cancer research 2005;65(19):8754-65.
2005: Lucia Altucci; Nicole Clarke; Angela Nebbioso; Annamaria Scognamiglio; Hinrich Gronemeyer
Acute myeloid leukemia: therapeutic impact of epigenetic drugs.
The international journal of biochemistry & cell biology 2005;37(9):1752-62.
2005: Nicole Clarke; Angela Nebbioso; Lucia Altucci; Hinrich Gronemeyer
TRAIL: at the center of drugable anti-tumor pathways.
Cell cycle (Georgetown, Tex.) 2005;4(7):914-8.
2005: Antonello Mai; Silvio Massa; Riccardo Pezzi; Silvia Simeoni; Dante Rotili; Angela Nebbioso; Annamaria Scognamiglio; Lucia Altucci; Peter Loidl; Gerald Brosch
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Journal of medicinal chemistry 2005;48(9):3344-53.
2005: Francesco P Jori; Marco A Napolitano; Mariarosa AD Melone; marilena cipollaro; Antonino Cascino; Lucia Altucci; Gianfranco Peluso; Antonio Giordano; Umberto Galderisi
Molecular pathways involved in neural in vitro differentiation of marrow stromal stem cells.
Journal of cellular biochemistry 2005;94(4):645-55.
2005: Alessandra Insinga; Silvia Monestiroli; Simona Ronzoni; Vania Gelmetti; Francesco Marchesi; Andrea Viale; Lucia Altucci; Clara Nervi; Saverio Minucci; Pier Giuseppe Pelicci
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway.
Nature medicine 2005;11(1):71-6.
2005: Angela Nebbioso; Nicole Clarke; Emilie Voltz; emmanuelle germain; Concetta Ambrosino; Paola Bontempo; Rosana Alvarez; Ettore Mariano Schiavone; Felicetto Ferrara; Francesco Bresciani; Alessandro Weisz; Angel R de Lera; Hinrich Gronemeyer; Lucia Altucci
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells.
Nature medicine 2005;11(1):77-84.
2004: Nicole Clarke; Pierre Germain; Lucia Altucci; Hinrich Gronemeyer
Retinoids: potential in cancer prevention and therapy.
Expert reviews in molecular medicine 2004;6(25):1-23.
2004: Ana M Jiménez-Lara; Nicole Clarke; Lucia Altucci; Hinrich Gronemeyer
Retinoic-acid-induced apoptosis in leukemia cells.
Trends in molecular medicine 2004;10(10):508-15.
2004: Alessandro Weisz; Walter Basile; Claudio Scafoglio; Lucia Altucci; Francesco Bresciani; Angelo Facchiano; Piero Sismondi; Luigi Cicatiello; Michele De Bortoli
Molecular identification of ERalpha-positive breast cancer cells by the expression profile of an intrinsic set of estrogen regulated genes.
Journal of cellular physiology 2004;200(3):440-50.
2004: Luigi Cicatiello; Raffaele Addeo; Antonio Sasso; Lucia Altucci; Valeria Belsito Petrizzi; Raphaelle Borgo; Massimo Cancemi; simona caporali; Silvana Caristi; Claudio Scafoglio; Diana Teti; Francesco Bresciani; Bruno Perillo; Alessandro Weisz
Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter.
Molecular and cellular biology 2004;24(16):7260-74.
2004: Luigi Cicatiello; Claudio Scafoglio; Lucia Altucci; Massimo Cancemi; Guido Natoli; Angelo Facchiano; Giovanni Iazzetti; Raffaele A Calogero; Nicoletta Biglia; Michele De Bortoli; Christian Sfiligoi; Piero Sismondi; Francesco Bresciani; Alessandro Weisz
A genomic view of estrogen actions in human breast cancer cells by expression profiling of the hormone-responsive transcriptome.
Journal of molecular endocrinology 2004;32(3):719-75.
2004: Lucia Altucci; Emmanuelle Wilhelm; Hinrich Gronemeyer
Leukemia: beneficial actions of retinoids and rexinoids.
The international journal of biochemistry & cell biology 2004;36(2):178-82.
2004: Lucia Altucci; Hinrich Gronemeyer
Retinoids and TRAIL: two cooperating actors to fight against cancer.
Vitamins and hormones 2004;67():319-45.
2003: simona caporali; Manami Imai; Lucia Altucci; Massimo Cancemi; Silvana Caristi; Luigi Cicatiello; Filomena Matarese; Roberta Penta; Dipak K Sarkar; Francesco Bresciani; Alessandro Weisz
Distinct signaling pathways mediate stimulation of cell cycle progression and prevention of apoptotic cell death by estrogen in rat pituitary tumor PR1 cells.
Molecular biology of the cell 2003;14(12):5051-9.
2003: Antonio De Luca; Alfonso Baldi; Patrizia Russo; Anna Todisco; Lucia Altucci; Nicola Giardullo; Luigi Pasquale; Salvatore Iaquinto; Vittorio D'Onofrio; Maria Caterina Parodi; Marco Giorgio Paggi; Gaetano Iaquinto
Coexpression of Helicobacter pylori's proteins CagA and HspB induces cell proliferation in AGS gastric epithelial cells, independently from the bacterial infection.
Cancer research 2003;63(19):6350-6.
2003: Annika Vienonen; Susanna Miettinen; Tommi Manninen; Lucia Altucci; Emmanuelle Wilhelm; Timo Ylikomi
Regulation of nuclear receptor and cofactor expression in breast cancer cell lines.
European journal of endocrinology / European Federation of Endocrine Societies 2003;148(4):469-79.
2002: Lucia Altucci; Hinrich Gronemeyer
Decryption of the retinoid death code in leukemia.
Journal of clinical immunology 2002;22(3):117-23.
2001: Lucia Altucci; Hinrich Gronemeyer
The promise of retinoids to fight against cancer.
Nature reviews. Cancer 2001;1(3):181-93.
2001: Lucia Altucci; Hinrich Gronemeyer
Nuclear receptors in cell life and death.
Trends in endocrinology and metabolism: TEM 2001;12(10):460-8.
2001: Silvana Caristi; J L Galera; F Matarese; M Imai; simona caporali; Massimo Cancemi; Lucia Altucci; Luigi Cicatiello; Diana Teti; Francesco Bresciani; Alessandro Weisz
Estrogens do not modify MAP kinase-dependent nuclear signaling during stimulation of early G(1) progression in human breast cancer cells.
Cancer research 2001;61(17):6360-6.
2001: Ya-Hua Zhuang; D Sarca; Alessandro Weisz; Lucia Altucci; Luigi Cicatiello; E Rollerova; Pentti Tuohimaa; Timo Ylikomi
Cell type-specific induction of cyclin D and cyclin-dependent kinase inhibitor p27(kip1) expression by estrogen in rat endometrium.
The Journal of steroid biochemistry and molecular biology 2001;78(2):193-9.
2001: GR Benoit; Maria Flexor; Françoise Besançon; Lucia Altucci; Aurélie Rossin; Josette Hillion; Zoltán Balajthy; Luc LEGRES; Evelyne Ségal-Bendirdjian; Hinrich Gronemeyer; Michel Lanotte
Autonomous rexinoid death signaling is suppressed by converging signaling pathways in immature leukemia cells.
Molecular endocrinology (Baltimore, Md.) 2001;15(7):1154-69.
2001: Lucia Altucci; Aurélie Rossin; Wolfgang Raffelsberger; Armin Reitmair; C Chomienne; Hinrich Gronemeyer
Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL.
Nature medicine 2001;7(6):680-6.
2001: D Germano; C Pacilio; Massimo Cancemi; Luigi Cicatiello; Lucia Altucci; Valeria Belsito Petrizzi; C Sperandio; S Salzano; Rob Michalides; Y Taya; Francesco Bresciani; Alessandro Weisz
Inhibition of human breast cancer cell growth by blockade of the mevalonate-protein prenylation pathway is not prevented by overexpression of cyclin D1.
Breast cancer research and treatment 2001;67(1):23-33.
2000: Luigi Cicatiello; Raffaele Addeo; Lucia Altucci; V Belsito Petrizzi; V Boccia; Massimo Cancemi; D Germano; C Pacilio; S Salzano; Francesco Bresciani; Alessandro Weisz
The antiestrogen ICI 182,780 inhibits proliferation of human breast cancer cells by interfering with multiple, sequential estrogen-regulated processes required for cell cycle completion.
Molecular and cellular endocrinology 2000;165(1-2):199-209.
1999: GR Benoit; Lucia Altucci; Maria Flexor; S Ruchaud; Johan R Lillehaug; Wolfgang Raffelsberger; Hinrich Gronemeyer; Michel Lanotte
RAR-independent RXR signaling induces t(15;17) leukemia cell maturation.
The EMBO journal 1999;18(24):7011-8.
1998: C Pacilio; D Germano; Raffaele Addeo; Lucia Altucci; Valeria Belsito Petrizzi; Massimo Cancemi; Luigi Cicatiello; S Salzano; F Lallemand; Rob Michalides; Francesco Bresciani; Alessandro Weisz
Constitutive overexpression of cyclin D1 does not prevent inhibition of hormone-responsive human breast cancer cell growth by antiestrogens.
Cancer research 1998;58(5):871-6.
1997: Lucia Altucci; Raffaele Addeo; Luigi Cicatiello; D Germano; C Pacilio; T Battista; Massimo Cancemi; Valeria Belsito Petrizzi; Francesco Bresciani; Alessandro Weisz
Estrogen induces early and timed activation of cyclin-dependent kinases 4, 5, and 6 and increases cyclin messenger ribonucleic acid expression in rat uterus.
Endocrinology 1997;138(3):978-84.
1996: Lucia Altucci; Raffaele Addeo; Luigi Cicatiello; S Dauvois; M G Parker; M Truss; M Beato; V Sica; Francesco Bresciani; Alessandro Weisz
17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells.
Oncogene 1996;12(11):2315-24.
1996: Raffaele Addeo; Lucia Altucci; T Battista; I M Bonapace; Massimo Cancemi; Luigi Cicatiello; D Germano; C Pacilio; S Salzano; Francesco Bresciani; Alessandro Weisz
Stimulation of human breast cancer MCF-7 cells with estrogen prevents cell cycle arrest by HMG-CoA reductase inhibitors.
Biochemical and biophysical research communications 1996;220(3):864-70.
1996: I M Bonapace; Raffaele Addeo; Lucia Altucci; Luigi Cicatiello; Maurizio Bifulco; Chiara Laezza; S Salzano; V Sica; Francesco Bresciani; Alessandro Weisz
17 beta-Estradiol overcomes a G1 block induced by HMG-CoA reductase inhibitors and fosters cell cycle progression without inducing ERK-1 and -2 MAP kinases activation.
Oncogene 1996;12(4):753-63.
1995: Luigi Cicatiello; G Cobellis; Raffaele Addeo; MICHELE PAPA; Lucia Altucci; V Sica; Francesco Bresciani; M LeMeur; V L Kumar; P Chambon
In vivo functional analysis of the mouse estrogen receptor gene promoter: a transgenic mouse model to study tissue-specific and developmental regulation of estrogen receptor gene transcription.
Molecular endocrinology (Baltimore, Md.) 1995;9(8):1077-90.