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Peter de Bruijn

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Ron H J Mathijssen; Peter de Bruijn; Karel Eechoute; Alex Sparreboom
Long-term prospective population PK study in GIST patients--response.
Anne-Joy M de Graan; Guoqing Du; Laure Elens; Lena E Friberg; Alice A Gibson; Bruno Hagenbuch; Shuiying Hu; Cynthia S Lancaster; Walter J Loos; Ron H J Mathijssen; Torben S Mikkelsen; Amanda Obaidat; Sharyn D Baker; Gitte H Bruun; Thomas J Corydon; Peter de Bruijn; Ron H N van Schaik; Aisha L Walker; Alex Sparreboom
Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel.
Gaia Schiavon; Stefan Sleijfer; Jessica van der Bol; Jaap Verweij; Peter de Bruijn; Karel Eechoute; Ron H J Mathijssen; Walter J Loos
Biliary excretion of imatinib and its active metabolite CGP74588 during severe hepatic dysfunction.

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All Publications

2013: Ron H J Mathijssen; Peter de Bruijn; Karel Eechoute; Alex Sparreboom
Long-term prospective population PK study in GIST patients--response.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(4):950.
2012: Anne-Joy M de Graan; Guoqing Du; Laure Elens; Lena E Friberg; Alice A Gibson; Bruno Hagenbuch; Shuiying Hu; Cynthia S Lancaster; Walter J Loos; Ron H J Mathijssen; Torben S Mikkelsen; Amanda Obaidat; Sharyn D Baker; Gitte H Bruun; Thomas J Corydon; Peter de Bruijn; Ron H N van Schaik; Aisha L Walker; Alex Sparreboom
Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(16):4433-40.
2012: Gaia Schiavon; Stefan Sleijfer; Jessica van der Bol; Jaap Verweij; Peter de Bruijn; Karel Eechoute; Ron H J Mathijssen; Walter J Loos
Biliary excretion of imatinib and its active metabolite CGP74588 during severe hepatic dysfunction.
Journal of clinical pharmacology 2012;52(7):1115-20.
2012: Peter de Bruijn; Anne-Joy M de Graan; Ronald de Wit; Mei-Ho Lam; Ron H J Mathijssen; Annemieke Nieuweboer; Erik A C Wiemer; Walter J Loos
Quantification of cabazitaxel in human plasma by liquid chromatography/triple-quadrupole mass spectrometry: a practical solution for non-specific binding.
Journal of pharmaceutical and biomedical analysis 2012;59():117-22.
2011: Lisette Binkhorst; Peter de Bruijn; Inge M Ghobadi Moghaddam-Helmantel; Ron H J Mathijssen; Teun van Gelder; Erik A C Wiemer; Walter J Loos
Quantification of tamoxifen and three of its phase-I metabolites in human plasma by liquid chromatography/triple-quadrupole mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2011;56(5):1016-23.
2011: Inge R H M Konings; Stefan Sleijfer; Ron H J Mathijssen; Peter de Bruijn; Inge M Ghobadi Moghaddam-Helmantel; Linda M van Dam; Erik A C Wiemer; Jaap Verweij; Walter J Loos
Increasing tumoral 5-fluorouracil concentrations during a 5-day continuous infusion: a microdialysis study.
Cancer chemotherapy and pharmacology 2011;67(5):1055-62.
2011: Jessica van der Bol; Walter J Loos; Floris A de Jong; Esther van Meerten; Inge R H M Konings; Mei H Lam; Peter de Bruijn; Erik A C Wiemer; Jaap Verweij; Ron H J Mathijssen
Effect of omeprazole on the pharmacokinetics and toxicities of irinotecan in cancer patients: a prospective cross-over drug-drug interaction study.
European journal of cancer (Oxford, England : 1990) 2011;47(6):831-8.
2011: Walter J Loos; Anne-Joy M de Graan; Peter de Bruijn; Ron H N van Schaik; Marianne A C van Fessem; Mei-Ho Lam; Ron H J Mathijssen; Erik A C Wiemer
Simultaneous quantification of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2011;54(2):387-94.
2011: Frederike K Engels; Walter J Loos; Jessica M van der Bol; Peter de Bruijn; Ron H J Mathijssen; Jaap Verweij; Ron A A Mathot
Therapeutic drug monitoring for the individualization of docetaxel dosing: a randomized pharmacokinetic study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(2):353-62.
2010: Peter de Bruijn; Stefan Sleijfer; Mei-Ho Lam; Ron H J Mathijssen; Erik A C Wiemer; Walter J Loos
Bioanalytical method for the quantification of sunitinib and its n-desethyl metabolite SU12662 in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2010;51(4):934-41.
2009: Peter de Bruijn; Inge M Ghobadi Moghaddam-Helmantel; Maja J A de Jonge; Thorsten Meyer; Mei-Ho Lam; Jaap Verweij; Erik A C Wiemer; Walter J Loos
Validated bioanalytical method for the quantification of RGB-286638, a novel multi-targeted protein kinase inhibitor, in human plasma and urine by liquid chromatography/tandem triple-quadrupole mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2009;50(5):977-82.
2008: Joan B Heijns; M E L van der Burg; Teun van Gelder; Marien W J A Fieren; Peter de Bruijn; Ate van der Gaast; Walter J Loos
Continuous ambulatory peritoneal dialysis: pharmacokinetics and clinical outcome of paclitaxel and carboplatin treatment.
Cancer chemotherapy and pharmacology 2008;62(5):841-7.
2007: Walter J Loos; William C Zamboni; Frederike K Engels; Peter de Bruijn; M H Lam; R de Wit; Jaap Verweij; Erik A C Wiemer
Pitfalls of the application of microdialysis in clinical oncology: controversial findings with docetaxel.
Journal of pharmaceutical and biomedical analysis 2007;45(2):288-94.
2007: Frederike K Engels; Floris A de Jong; Alex Sparreboom; Ron A A Mathot; Walter J Loos; Jos J E M Kitzen; Peter de Bruijn; Jaap Verweij; Ron H J Mathijssen
Medicinal cannabis does not influence the clinical pharmacokinetics of irinotecan and docetaxel.
The oncologist 2007;12(3):291-300.
2007: Walter J Loos; Ronald de Wit; Steven J Freedman; Kristien Van Dyck; Jay J Gambale; Susie Li; Gail M Murphy; Connie van Noort; Peter de Bruijn; Jaap Verweij
Aprepitant when added to a standard antiemetic regimen consisting of ondansetron and dexamethasone does not affect vinorelbine pharmacokinetics in cancer patients.
Cancer chemotherapy and pharmacology 2007;59(3):407-12.
2006: A Felici; Walter J Loos; Jaap Verweij; I Cirillo; Peter de Bruijn; Kees Nooter; Ron H J Mathijssen; M J A de Jonge
A pharmacokinetic interaction study of docetaxel and cisplatin plus or minus 5-fluorouracil in the treatment of patients with recurrent or metastatic solid tumors.
Cancer chemotherapy and pharmacology 2006;58(5):673-80.
2006: Floris A de Jong; Jos J E M Kitzen; Peter de Bruijn; Jaap Verweij; Walter J Loos
Hepatic transport, metabolism and biliary excretion of irinotecan in a cancer patient with an external bile drain.
Cancer biology & therapy 2006;5(9):1105-10.
2006: Floris A de Jong; Diederik F S Kehrer; Ron H J Mathijssen; Geert-Jan Creemers; Peter de Bruijn; Ron van Schaik; A S T Planting; Ate van der Gaast; Ferry A L M Eskens; Jos Th P Janssen; Jan B Ruit; Jaap Verweij; Alex Sparreboom; M J A de Jonge
Prophylaxis of irinotecan-induced diarrhea with neomycin and potential role for UGT1A1*28 genotype screening: a double-blind, randomized, placebo-controlled study.
The oncologist 2006;11(8):944-54.
2004: Ron H J Mathijssen; Floris A de Jong; Ron van Schaik; Erin R Lepper; Lena E Friberg; Trinet Rietveld; Peter de Bruijn; Wilfried J Graveland; William D Figg; Jaap Verweij; Alex Sparreboom
Prediction of irinotecan pharmacokinetics by use of cytochrome P450 3A4 phenotyping probes.
Journal of the National Cancer Institute 2004;96(21):1585-92.
2004: Peter de Bruijn; Edwin W Willems; Walter J Loos; Jaap Verweij; Alex Sparreboom
Indirect determination of the irinotecan metabolite 7-ethyl-10-O-glucuronyl-camptothecin in human samples.
Analytical biochemistry 2004;328(1):84-6.
2004: Alex Sparreboom; Diederik F S Kehrer; Ron H J Mathijssen; R Xie; M J A de Jonge; Peter de Bruijn; A S T Planting; Ferry A L M Eskens; Coleta Verheij; Gerda de Heus; A Klaren; S Zhang; Tom Verhaeghe; Peter A Palmer; Jaap Verweij
Phase I and pharmacokinetic study of irinotecan in combination with R115777, a farnesyl protein transferase inhibitor.
British journal of cancer 2004;90(8):1508-15.
2004: Lia van Zuylen; John Bridgewater; Alex Sparreboom; Ferry A L M Eskens; Peter de Bruijn; Ivo Sklenar; A S T Planting; Les Choi; Douglas Bootle; Christian Mueller; Jonathan A Ledermann; Jaap Verweij
Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(6):1949-55.
2004: Otto Soepenberg; Peter de Bruijn; Jaap Verweij; Ryo Atsumi; Alex Sparreboom
Liquid chromatographic assays for DE-310, a novel camptothecin analog, and two major enzymatic products in human matrices.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;799(1):15-22.
2003: Floris A de Jong; Ron H J Mathijssen; Peter de Bruijn; Walter J Loos; Jaap Verweij; Alex Sparreboom
Determination of irinotecan (CPT-11) and SN-38 in human whole blood and red blood cells by liquid chromatography with fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;795(2):383-8.
2002: Ron H J Mathijssen; Jaap Verweij; Peter de Bruijn; Walter J Loos; Alex Sparreboom
Effects of St. John's wort on irinotecan metabolism.
Journal of the National Cancer Institute 2002;94(16):1247-9.
2002: Diederik F S Kehrer; Ron H J Mathijssen; Jaap Verweij; Peter de Bruijn; Alex Sparreboom
Modulation of irinotecan metabolism by ketoconazole.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(14):3122-9.
2002: Ron H J Mathijssen; Jaap Verweij; Walter J Loos; Peter de Bruijn; Kees Nooter; Alex Sparreboom
Irinotecan pharmacokinetics-pharmacodynamics: the clinical relevance of prolonged exposure to SN-38.
British journal of cancer 2002;87(2):144-50.
2002: Walter J Loos; Jaap Verweij; Diederik F S Kehrer; Peter de Bruijn; Franciscus M H de Groot; Marta Hamilton; Kees Nooter; Gerrit Stoter; Alex Sparreboom
Structural identification and biological activity of 7-methyl-10,11-ethylenedioxy-20(S)-camptothecin, a photodegradant of lurtotecan.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(3):856-62.
2001: Franciscus M H de Groot; W J Loos; R Koekkoek; Leon W A van Berkom; Guuske F Busscher; A E Seelen; C Albrecht; Peter de Bruijn; Hans W Scheeren
Elongated multiple electronic cascade and cyclization spacer systems in activatible anticancer prodrugs for enhanced drug release.
The Journal of organic chemistry 2001;66(26):8815-30.
2001: W Yamamoto; Jaap Verweij; Peter de Bruijn; M J A de Jonge; H Takano; M Nishiyama; M Kurihara; Alex Sparreboom
Active transepithelial transport of irinotecan (CPT-11) and its metabolites by human intestinal Caco-2 cells.
Anti-cancer drugs 2001;12(5):419-32.
2001: Diederik F S Kehrer; Alex Sparreboom; Jaap Verweij; Peter de Bruijn; C A Nierop; J van de Schraaf; E J Ruijgrok; M J A de Jonge
Modulation of irinotecan-induced diarrhea by cotreatment with neomycin in cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(5):1136-41.
2001: Peter de Bruijn; Diederik F S Kehrer; Jaap Verweij; Alex Sparreboom
Liquid chromatographic determination of ketoconazole, a potent inhibitor of CYP3A4-mediated metabolism.
Journal of chromatography. B, Biomedical sciences and applications 2001;753(2):395-400.
2001: Lia van Zuylen; M O Karlsson; Jaap Verweij; E Brouwer; Peter de Bruijn; Kees Nooter; Gerrit Stoter; Alex Sparreboom
Pharmacokinetic modeling of paclitaxel encapsulation in Cremophor EL micelles.
Cancer chemotherapy and pharmacology 2001;47(4):309-18.
2000: E Brouwer; Jaap Verweij; Peter de Bruijn; Walter J Loos; M Pillay; Dirk Buijs; Alex Sparreboom
Measurement of fraction unbound paclitaxel in human plasma.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(10):1141-5.
2000: Diederik F S Kehrer; W Yamamoto; Jaap Verweij; M J A de Jonge; Peter de Bruijn; Alex Sparreboom
Factors involved in prolongation of the terminal disposition phase of SN-38: clinical and experimental studies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(9):3451-8.
2000: Walter J Loos; Peter de Bruijn; Jaap Verweij; Alex Sparreboom
Determination of camptothecin analogs in biological matrices by high-performance liquid chromatography.
Anti-cancer drugs 2000;11(5):315-24.
2000: Walter J Loos; Diederik F S Kehrer; E Brouwer; Jaap Verweij; Peter de Bruijn; Marta Hamilton; S Gill; Kees Nooter; Gerrit Stoter; Alex Sparreboom
Liposomal lurtotecan (NX211): determination of total drug levels in human plasma and urine by reversed-phase high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2000;738(1):155-63.
2000: M J A de Jonge; Jaap Verweij; Peter de Bruijn; E Brouwer; Ron H J Mathijssen; RJ van Alphen; MM de Boer-Dennert; Laurent Vernillet; Christian Jacques; Alex Sparreboom
Pharmacokinetic, metabolic, and pharmacodynamic profiles in a dose-escalating study of irinotecan and cisplatin.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(1):195-203.
1999: Walter J Loos; Peter de Bruijn; Lia van Zuylen; Jaap Verweij; Kees Nooter; Gerrit Stoter; Alex Sparreboom
Determination of 5-fluorouracil in microvolumes of human plasma by solvent extraction and high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1999;735(2):293-7.
1999: Hans Gelderblom; Jaap Verweij; E Brouwer; M Pillay; Peter de Bruijn; Kees Nooter; Gerrit Stoter; Alex Sparreboom
Disposition of [G-(3)H]paclitaxel and cremophor EL in a patient with severely impaired renal function.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(11):1300-5.
1999: Alex Sparreboom; A S T Planting; Roxanne C Jewell; M E L van der Burg; Ate van der Gaast; Peter de Bruijn; Walter J Loos; Kees Nooter; L H Chandler; Elaine M Paul; Paul Wissel; Jaap Verweij
Clinical pharmacokinetics of doxorubicin in combination with GF120918, a potent inhibitor of MDR1 P-glycoprotein.
Anti-cancer drugs 1999;10(8):719-28.
1999: M J A de Jonge; Jaap Verweij; A S T Planting; M E L van der Burg; Gerrit Stoter; MM de Boer-Dennert; Peter de Bruijn; E Brouwer; Laurent Vernillet; Alex Sparreboom
Drug-administration sequence does not change pharmacodynamics and kinetics of irinotecan and cisplatin.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(8):2012-7.
1999: Peter de Bruijn; M J de Jonge; J Verweij; W J Loos; Kees Nooter; Gerrit Stoter; Alex Sparreboom
Femtomole quantitation of 7-ethyl-10-hydroxycamptothecine (SN-38) in plasma samples by reversed-phase high-performance liquid chromatography.
Analytical biochemistry 1999;269(1):174-8.
1999: Alex Sparreboom; Lia van Zuylen; E Brouwer; Walter J Loos; Peter de Bruijn; Hans Gelderblom; M Pillay; Kees Nooter; Gerrit Stoter; Jaap Verweij
Cremophor EL-mediated alteration of paclitaxel distribution in human blood: clinical pharmacokinetic implications.
Cancer research 1999;59(7):1454-7.
1999: Peter de Bruijn; Jaap Verweij; Walter J Loos; HJ Kolker; A S T Planting; Kees Nooter; Gerrit Stoter; Alex Sparreboom
Determination of doxorubicin and doxorubicinol in plasma of cancer patients by high-performance liquid chromatography.
Analytical biochemistry 1999;266(2):216-21.
1999: Ron H J Mathijssen; RJ van Alphen; M J A de Jonge; Jaap Verweij; Peter de Bruijn; Walter J Loos; Kees Nooter; Laurent Vernillet; Gerrit Stoter; Alex Sparreboom
Sparse-data set analysis for irinotecan and SN-38 pharmacokinetics in cancer patients co-treated with cisplatin.
Anti-cancer drugs 1999;10(1):9-16.
1998: Alex Sparreboom; M J A de Jonge; Peter de Bruijn; E Brouwer; Kees Nooter; Walter J Loos; RJ van Alphen; Ron H J Mathijssen; Gerrit Stoter; Jaap Verweij
Irinotecan (CPT-11) metabolism and disposition in cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(11):2747-54.
1998: Alex Sparreboom; Peter de Bruijn; M J A de Jonge; Walter J Loos; Gerrit Stoter; Jaap Verweij; Kees Nooter
Liquid chromatographic determination of irinotecan and three major metabolites in human plasma, urine and feces.
Journal of chromatography. B, Biomedical sciences and applications 1998;712(1-2):225-35.
1998: Alex Sparreboom; Peter de Bruijn; Kees Nooter; Walter J Loos; Gerrit Stoter; Jaap Verweij
Determination of paclitaxel in human plasma using single solvent extraction prior to isocratic reversed-phase high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography. B, Biomedical sciences and applications 1998;705(1):159-64.
1997: AI de Vos; Kees Nooter; Jaap Verweij; Walter J Loos; E Brouwer; Peter de Bruijn; E J Ruijgrok; M E L van der Burg; Gerrit Stoter; Alex Sparreboom
Differential modulation of cisplatin accumulation in leukocytes and tumor cell lines by the paclitaxel vehicle Cremophor EL.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1997;8(11):1145-50.
1997: Peter de Bruijn; Jaap Verweij; Walter J Loos; Kees Nooter; Gerrit Stoter; Alex Sparreboom
Determination of irinotecan (CPT-11) and its active metabolite SN-38 in human plasma by reversed-phase high-performance liquid chromatography with fluorescence detection.
Journal of chromatography. B, Biomedical sciences and applications 1997;698(1-2):277-85.