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Mark de Caestecker

Research Profile

Chemicals & Drugs

Physiology

Concepts & Ideas

Disorders

Wilms' Tumor

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Publications

TOP 3
Andrew J Murphy; Alan O Perantoni; Janene Pierce; Teagan Walter; Zhiguo Zhao; Gregory D Ayers; Scott C Boyle; Hernan Correa; Christian de Caestecker; Mark de Caestecker; Stacey S Huppert; Jaime M Libes; Harold N Lovvorn
CITED1 expression in liver development and hepatoblastoma.
Andrew J Murphy; Mark W Newton; Janene Pierce; Erin H Seeley; Jason R Axt; Richard M Caprioli; Hernan Correa; Christian de Caestecker; Mark de Caestecker; Harold N Lovvorn
Molecular characterization of Wilms' tumor from a resource-constrained region of sub-Saharan Africa.
Andrew J Murphy; Alan O Perantoni; Janene Pierce; Chase Taylor; James R Anderson; Christian de Caestecker; Mark de Caestecker; Harold N Lovvorn
SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor.

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All Publications

2012: Andrew J Murphy; Alan O Perantoni; Janene Pierce; Teagan Walter; Zhiguo Zhao; Gregory D Ayers; Scott C Boyle; Hernan Correa; Christian de Caestecker; Mark de Caestecker; Stacey S Huppert; Jaime M Libes; Harold N Lovvorn
CITED1 expression in liver development and hepatoblastoma.
Neoplasia (New York, N.Y.) 2012;14(12):1153-63.
2012: Andrew J Murphy; Mark W Newton; Janene Pierce; Erin H Seeley; Jason R Axt; Richard M Caprioli; Hernan Correa; Christian de Caestecker; Mark de Caestecker; Harold N Lovvorn
Molecular characterization of Wilms' tumor from a resource-constrained region of sub-Saharan Africa.
International journal of cancer. Journal international du cancer 2012;131(6):E983-94.
2012: Andrew J Murphy; Alan O Perantoni; Janene Pierce; Chase Taylor; James R Anderson; Christian de Caestecker; Mark de Caestecker; Harold N Lovvorn
SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor.
Journal of pediatric surgery 2012;47(6):1239-49.
2011: Peter E Clark; Cheryl Coffin; Hernan Correa; Mark de Caestecker; Harold Love; Harold L Moses; Elizabeth J Perlman; Dina Polosukhina; Roy Zent
β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors.
The American journal of pathology 2011;179(6):3045-55.
2011: Tatiana Novitskaya; Mariana Baserga; Mark de Caestecker
Organ-specific defects in insulin-like growth factor and insulin receptor signaling in late gestational asymmetric intrauterine growth restriction in Cited1 mutant mice.
Endocrinology 2011;152(6):2503-16.
2009: Duncan B Sparrow; Scott C Boyle; Rebecca S Sams; Bogdan Mazuruk; Li Zhang; Gilbert W Moeckel; Sally L Dunwoodie; Mark de Caestecker
Placental insufficiency associated with loss of Cited1 causes renal medullary dysplasia.
Journal of the American Society of Nephrology : JASN 2009;20(4):777-86.
2008: Scott Boyle; Andrew Misfeldt; Kelly J Chandler; Karen K Deal; E Michelle Southard-Smith; Douglas P Mortlock; H Scott Baldwin; Mark de Caestecker
Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia.
Developmental biology 2008;313(1):234-45.
2008: David B Frank; Jonathan Lowery; Lynda Anderson; Monique Brink; Jeff Reese; Mark de Caestecker
Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature.
American journal of physiology. Lung cellular and molecular physiology 2008;294(1):L98-109.
2007: Scott Boyle; Toshi Shioda; Alan O Perantoni; Mark de Caestecker
Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(8):2321-30.
2007: Harold N Lovvorn; Jenifer Westrup; Shaun Opperman; Scott Boyle; Genbin Shi; James Anderson; Elizabeth J. Perlman; Alan O Perantoni; Marcia L Wills; Mark de Caestecker
CITED1 expression in Wilms' tumor and embryonic kidney.
Neoplasia (New York, N.Y.) 2007;9(7):589-600.
2007: Harold N Lovvorn; Scott Boyle; Genbin Shi; Yu Shyr; Marcia L Wills; Alan O Perantoni; Mark de Caestecker
Wilms' tumorigenesis is altered by misexpression of the transcriptional co-activator, CITED1.
Journal of pediatric surgery 2007;42(3):474-81.
2006: Genbin Shi; Scott C Boyle; Duncan B Sparrow; Sally L Dunwoodie; Toshi Shioda; Mark de Caestecker
The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner.
The Journal of biological chemistry 2006;281(37):27426-35.
2006: Scott Boyle; Mark de Caestecker
Role of transcriptional networks in coordinating early events during kidney development.
American journal of physiology. Renal physiology 2006;291(1):F1-8.
2005: David Frank; Joyce Johnson; Mark de Caestecker
Bone morphogenetic protein 4 promotes vascular remodeling in hypoxic pulmonary hypertension.
Chest 2005;128(6 Suppl):590S-591S.
2005: David B Frank; Amir Abtahi; D J Yamaguchi; Suzanne Manning; Yu Shyr; Ambra Pozzi; H Scott Baldwin; Joyce E Johnson; Mark de Caestecker
Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension.
Circulation research 2005;97(5):496-504.
2005: Sergey Plisov; Michael Tsang; Genbin Shi; Scott Boyle; Kiyoshi Yoshino; Sally L Dunwoodie; Igor B Dawid; Toshi Shioda; Alan O Perantoni; Mark de Caestecker
Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning.
Journal of the American Society of Nephrology : JASN 2005;16(6):1632-44.
2002: Mark de Caestecker; Martyn Bottomley; Sucharita Bhattacharyya; Tracie L Payne; Anita B Roberts; Pamela C Yelick
The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII.
Biochemical and biophysical research communications 2002;293(5):1556-65.
2001: W Tony Parks; David B Frank; C Huff; C Renfrew Haft; J Martin; X Meng; Mark de Caestecker; James G McNally; A Reddi; Simeon I Taylor; Anita B Roberts; Tongwen Wang; Robert J Lechleider
Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.
The Journal of biological chemistry 2001;276(22):19332-9.
2001: Dug Keun Lee; S H Park; Y Yi; SG Choi; Chan Lee; W Tony Parks; H Cho; Mark de Caestecker; Y Shaul; Anita B Roberts; Seong-Jin Kim
The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis.
Genes & development 2001;15(4):455-66.
2001: Mark de Caestecker; Barbara Meyrick
Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension.
Respiratory research 2001;2(4):193-7.
2000: Sarit Larisch; Y Yi; Rona Lotan; Hedviga Kerner; Sarah Eimerl; W Tony Parks; Yossi Gottfried; S Birkey Reffey; Mark de Caestecker; David Danielpour; N Book-Melamed; Rina Timberg; Colin S Duckett; Robert J Lechleider; Hermann Steller; Joseph Orly; S J Kim; Anita B Roberts
A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.
Nature cell biology 2000;2(12):915-21.
2000: Michael Tsang; R Kim; Mark de Caestecker; Tetsuhiro Kudoh; Anita B Roberts; Igor B Dawid
Zebrafish nma is involved in TGFbeta family signaling.
Genesis (New York, N.Y. : 2000) 2000;28(2):47-57.
2000: Mark de Caestecker; Ester Piek; Anita B Roberts
Role of transforming growth factor-beta signaling in cancer.
Journal of the National Cancer Institute 2000;92(17):1388-402.
2000: Richard H Kim; D Wang; Michael Tsang; J Martin; C Huff; Mark de Caestecker; W Tony Parks; X Meng; Robert J Lechleider; Tongwen Wang; Anita B Roberts
A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.
Genes & development 2000;14(13):1605-16.
2000: Tetsuro Yahata; Mark de Caestecker; Robert J Lechleider; S Andriole; Anita B Roberts; Kurt J Isselbacher; Toshi Shioda
The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors.
The Journal of biological chemistry 2000;275(12):8825-34.
2000: Mark de Caestecker; Tetsuro Yahata; D Wang; W Tony Parks; S Huang; C S Hill; Toshi Shioda; Anita B Roberts; Robert J Lechleider
The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain.
The Journal of biological chemistry 2000;275(3):2115-22.
1998: L Vindevoghel; Robert J Lechleider; A Kon; Mark de Caestecker; Jouni Uitto; Anita B Roberts; Alain Mauviel
SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14769-74.
1998: Toshi Shioda; Robert J Lechleider; Sally L Dunwoodie; H Li; Tetsuro Yahata; Mark de Caestecker; Martin Fenner; Anita B Roberts; Kurt J Isselbacher
Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):9785-90.
1998: Mark de Caestecker; W Tony Parks; C J Frank; P Castagnino; Donald Bottaro; Anita B Roberts; Robert J Lechleider
Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases.
Genes & development 1998;12(11):1587-92.
1997: Mark de Caestecker; P Hemmati; S Larisch-Bloch; R Ajmera; Anita B Roberts; Robert J Lechleider
Characterization of functional domains within Smad4/DPC4.
The Journal of biological chemistry 1997;272(21):13690-6.
1996: Robert J Lechleider; Mark de Caestecker; A Dehejia; Mihael H Polymeropoulos; Anita B Roberts
Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1.
The Journal of biological chemistry 1996;271(30):17617-20.