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Alain De Caro

Research Profile

Chemicals & Drugs

Anatomy

Genes & Molecular Sequences

Amino Acid Sequences

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Physiology

Enzyme Activation

Procedures

Enzyme-Linked Immunosorbent Assay

Publications

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Sawsan Amara; Nathalie Barouh; Jérôme Lecomte; Dominique Lafont; Sylvie Robert; Pierre Villeneuve; Alain De Caro; Frédéric Carrière
Lipolysis of natural long chain and synthetic medium chain galactolipids by pancreatic lipase-related protein 2.
Sawsan Amara; Dominique Lafont; Brice Fiorentino; Paul Boullanger; Frédéric Carrière; Alain De Caro
Continuous measurement of galactolipid hydrolysis by pancreatic lipolytic enzymes using the pH-stat technique and a medium chain monogalactosyl diglyceride as substrate.
Josiane De Caro; Cécilia Eydoux; Slim Chérif; Régine Lebrun; Laboratoire Biochimie et Genie Enzymatique des Lipases; Frédéric Carrière; Alain De Caro
Occurrence of pancreatic lipase-related protein-2 in various species and its relationship with herbivore diet.

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All Publications

2010: Sawsan Amara; Nathalie Barouh; Jérôme Lecomte; Dominique Lafont; Sylvie Robert; Pierre Villeneuve; Alain De Caro; Frédéric Carrière
Lipolysis of natural long chain and synthetic medium chain galactolipids by pancreatic lipase-related protein 2.
Biochimica et biophysica acta 2010;1801(4):508-16.
2009: Sawsan Amara; Dominique Lafont; Brice Fiorentino; Paul Boullanger; Frédéric Carrière; Alain De Caro
Continuous measurement of galactolipid hydrolysis by pancreatic lipolytic enzymes using the pH-stat technique and a medium chain monogalactosyl diglyceride as substrate.
Biochimica et biophysica acta 2009;1791(10):983-90.
2008: Josiane De Caro; Cécilia Eydoux; Slim Chérif; Régine Lebrun; Laboratoire Biochimie et Genie Enzymatique des Lipases; Frédéric Carrière; Alain De Caro
Occurrence of pancreatic lipase-related protein-2 in various species and its relationship with herbivore diet.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2008;150(1):1-9.
2007: Karen Côtes; Rabeb Dhouib; Isabelle Douchet; Henri Chahinian; Alain De Caro; Frédéric Carrière; Stéphane Canaan
Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids.
The Biochemical journal 2007;408(3):417-27.
2007: Ahmed Aloulou; Delphine Puccinelli; Alain De Caro; Yves Leblond; Frédéric Carrière
A comparative study on two fungal lipases from Thermomyces lanuginosus and Yarrowia lipolytica shows the combined effects of detergents and pH on lipase adsorption and activity.
Biochimica et biophysica acta 2007;1771(12):1446-56.
2007: Cécilia Eydoux; Josiane De Caro; Francine Ferrato; Paul Boullanger; Dominique Lafont; René Laugier; Frédéric Carrière; Alain De Caro
Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells.
Journal of lipid research 2007;48(7):1539-49.
2006: Cécilia Eydoux; Ahmed Aloulou; Josiane De Caro; Philippe Grandval; René Laugier; Frédéric Carrière; Alain De Caro
Human pancreatic lipase-related protein 2: tissular localization along the digestive tract and quantification in pancreatic juice using a specific ELISA.
Biochimica et biophysica acta 2006;1760(10):1497-504.
2006: Nacim Zouari; Alain Bernadac; Nabil Miled; Tarak Rebai; Alain De Caro; Souad Rouis; Frederic Carriere; Laboratoire Biochimie et Genie Enzymatique des Lipases
Immunocytochemical localization of scorpion digestive lipase.
Biochimica et biophysica acta 2006;1760(9):1386-92.
2006: Ahmed Aloulou; Philippe Grandval; Josiane De Caro; Alain De Caro; Frédéric Carrière
Constitutive expression of human pancreatic lipase-related protein 1 in Pichia pastoris.
Protein expression and purification 2006;47(2):415-21.
2005: Hubert Halimi; Josiane De Caro; Frédéric Carrière; Alain De Caro
Closed and open conformations of the lid domain induce different patterns of human pancreatic lipase antigenicity and immunogenicity.
Biochimica et biophysica acta 2005;1753(2):247-56.
2004: Josiane De Caro; Barbara Sias; Philippe Grandval; Francine Ferrato; Hubert Halimi; Frédéric Carrière; Alain De Caro
Characterization of pancreatic lipase-related protein 2 isolated from human pancreatic juice.
Biochimica et biophysica acta 2004;1701(1-2):89-99.
2004: Barbara Sias; Francine Ferrato; Philippe Grandval; Dominique Lafont; Paul Boullanger; Alain De Caro; Bernard Leboeuf; Robert Verger; Frédéric Carrière
Human pancreatic lipase-related protein 2 is a galactolipase.
Biochemistry 2004;43(31):10138-48.
2004: Philippe Grandval; Alain De Caro; Josiane De Caro; Barbara Sias; Frédéric Carrière; Robert Verger; René Laugier
Critical evaluation of a specific ELISA and two enzymatic assays of pancreatic lipases in human sera.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2004;4(6):495-503; discussion 503-4.
2003: Laboratoire Biochimie et Genie Enzymatique des Lipases; Cecile Bussetta; Alain De Caro; Mireille Rivière; L Berti; Stéphane Canaan
Importance of the lid and cap domains for the catalytic activity of gastric lipases.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2003;136(1):131-8.
2001: Frédéric Carrière; Christophe Renou; S Ransac; V Lopez; Josiane De Caro; Francine Ferrato; Alain De Caro; A Fleury; P Sanwald-Ducray; Hans Lengsfeld; Christoph Beglinger; P Hadvary; Robert Verger; René Laugier
Inhibition of gastrointestinal lipolysis by Orlistat during digestion of test meals in healthy volunteers.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(1):G16-28.
2000: Laboratoire Biochimie et Genie Enzymatique des Lipases; Stéphane Canaan; L Dupuis; Alain Roussel; Mireille Rivière; Frédéric Carrière; Alain De Caro; Christian Cambillau; Robert Verger
Digestive lipases: from three-dimensional structure to physiology.
Biochimie 2000;82(11):973-86.
2000: Frédéric Carrière; Christophe Renou; V Lopez; Josiane De Caro; Francine Ferrato; Hans Lengsfeld; Alain De Caro; René Laugier; Robert Verger
The specific activities of human digestive lipases measured from the in vivo and in vitro lipolysis of test meals.
Gastroenterology 2000;119(4):949-60.
2000: Laboratoire Biochimie et Genie Enzymatique des Lipases; Alain De Caro; Josiane De Caro; Robert Verger
A conformational transition between an open and closed form of human pancreatic lipase revealed by a monoclonal antibody.
Biochimica et biophysica acta 2000;1476(2):165-72.
1999: Alain De Caro; Laboratoire Biochimie et Genie Enzymatique des Lipases; V Lopez; M Aoubala; C Daniel; Robert Verger; Frédéric Carrière
Immunological characterization of digestive lipases.
Methods in molecular biology (Clifton, N.J.) 1999;109():239-56.
1999: Laboratoire Biochimie et Genie Enzymatique des Lipases; Francine Ferrato; V Lopez; Alain De Caro; Robert Verger; Frédéric Carrière
One-step purification and biochemical characterization of recombinant pancreatic lipases expressed in insect cells.
Methods in molecular biology (Clifton, N.J.) 1999;109():187-202.
1998: Josiane De Caro; Frédéric Carrière; P Barboni; T Giller; Robert Verger; Alain De Caro
Pancreatic lipase-related protein 1 (PLRP1) is present in the pancreatic juice of several species.
Biochimica et biophysica acta 1998;1387(1-2):331-41.
1998: Alain Roussel; Josiane De Caro; Laboratoire Biochimie et Genie Enzymatique des Lipases; LN Gastinel; Alain De Caro; Frédéric Carrière; S Leydier; Robert Verger; Christian Cambillau
Reactivation of the totally inactive pancreatic lipase RP1 by structure-predicted point mutations.
Proteins 1998;32(4):523-31.
1998: Laboratoire Biochimie et Genie Enzymatique des Lipases; Frédéric Carrière; Josiane De Caro; Robert Verger; Alain De Caro
Human pancreatic lipase: an exposed hydrophobic loop from the C-terminal domain may contribute to interfacial binding.
Biochemistry 1998;37(34):11846-55.
1998: Josiane De Caro; Robert Verger; Alain De Caro
An enzymatically active truncated form (-55 N-terminal residues) of rabbit gastric lipase. Correlation between the enzymatic activity and disulfide bond oxydo-reduction state.
Biochimica et biophysica acta 1998;1386(1):39-49.
1998: Laboratoire Biochimie et Genie Enzymatique des Lipases; Alain Roussel; Josiane De Caro; LN Gastinel; Alain De Caro; Frédéric Carrière; S Leydier; Robert Verger; Christian Cambillau
An inactive pancreatic lipase-related protein is activated into a triglyceride-lipase by mutagenesis based on the 3-D structure.
Chemistry and physics of lipids 1998;93(1-2):103-14.
1997: M Aoubala; Isabelle Douchet; Laboratoire Biochimie et Genie Enzymatique des Lipases; M Hirn; Robert Verger; Alain De Caro
Immunological techniques for the characterization of digestive lipases.
Methods in enzymology 1997;286():126-49.
1996: Robert Verger; M Aoubalå; Frédéric Carrière; S Ransac; L Dupuis; Josiane De Caro; Francine Ferrato; I Douchet; R Laugier; Alain De Caro
Regulation of lumen fat digestion: enzymic aspects.
The Proceedings of the Nutrition Society 1996;55(1B):5-18.
1995: Josiane De Caro; Francine Ferrato; Robert Verger; Alain De Caro
Purification and molecular characterization of lamb pregastric lipase.
Biochimica et biophysica acta 1995;1252(2):321-9.
1995: M Aoubala; M Ivanova; I Douchet; Alain De Caro; Robert Verger
Interfacial binding of human gastric lipase to lipid monolayers, measured with an ELISA.
Biochemistry 1995;34(34):10786-93.
1995: M Aoubala; L de la Fournière; I Douchet; A Abousalham; C Daniel; M Hirn; Laboratoire Biochimie et Genie Enzymatique des Lipases; Robert Verger; Alain De Caro
Human pancreatic lipase. Importance of the hinge region between the two domains, as revealed by monoclonal antibodies.
The Journal of biological chemistry 1995;270(8):3932-7.
1994: M Aoubala; J Bonicel; C Bénicourt; Robert Verger; Alain De Caro
Tryptic cleavage of gastric lipases: location of the single disulfide bridge.
Biochimica et biophysica acta 1994;1213(3):319-24.
1993: M Aoubala; I Douchet; R Laugier; M Hirn; Robert Verger; Alain De Caro
Purification of human gastric lipase by immunoaffinity and quantification of this enzyme in the duodenal contents using a new ELISA procedure.
Biochimica et biophysica acta 1993;1169(2):183-8.
1993: M Aoubala; C Daniel; Alain De Caro; M G Ivanova; M Hirn; Louis Sarda; Robert Verger
Epitope mapping and immunoinactivation of human gastric lipase using five monoclonal antibodies.
European journal of biochemistry / FEBS 1993;211(1-2):99-104.
1992: J P Bernard; Z Adrich; G Montalto; Alain De Caro; Max de Reggi; H Sarles; Jean-Charles Dagorn
Inhibition of nucleation and crystal growth of calcium carbonate by human lithostathine.
Gastroenterology 1992;103(4):1277-84.
1991: J P Bernard; Z Adrich; G Montalto; L Multigner; Jean-Charles Dagorn; H Sarles; Alain De Caro
Immunoreactive forms of pancreatic stone protein in six mammalian species.
Pancreas 1991;6(2):162-7.
1989: Alain De Caro; Z Adrich; B Fournet; Calliope Capon; J J Bonicel; Josiane De Caro; M Rovery
N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue.
Biochimica et biophysica acta 1989;994(3):281-4.
1989: Z Adrich; Alain De Caro; A A Guidoni; M E Woudstra; M Rovery
Characterization in rat pancreatic juice of a protein homologous to the human pancreatic stone protein.
Comparative biochemistry and physiology. B, Comparative biochemistry 1989;93(4):793-7.
1988: Alain De Caro; L Multigner; Jean-Charles Dagorn; H Sarles
The human pancreatic stone protein.
Biochimie 1988;70(9):1209-14.
1988: Patrick ROUIMI; Josiane De Caro; J Bonicel; M Rovery; Alain De Caro
The disulfide bridges of the immunoreactive forms of human pancreatic stone protein isolated from pancreatic juice.
FEBS letters 1988;229(1):171-4.
1988: G Montalto; L Multigner; H Sarles; Alain De Caro
Organic matrix of pancreatic stones associated with nutritional pancreatitis.
Pancreas 1988;3(3):263-8.
1987: Alain De Caro; J J Bonicel; Patrick ROUIMI; Josiane De Caro; H Sarles; M Rovery
Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice.
European journal of biochemistry / FEBS 1987;168(1):201-7.
1987: Patrick ROUIMI; J Bonicel; M Rovery; Alain De Caro
Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein.
FEBS letters 1987;216(2):195-9.
1986: M Provansal-Cheylan; M Lusher; Alain De Caro; L Multigner; G Montalto; H Sarles; M Delaage
Monoclonal antibodies to pancreatic stone protein. Radioimmunoassay and immunological comparison with trypsin 1.
Biochimie 1986;68(9):1109-13.
1986: G Montalto; J Bonicel; L Multigner; M Rovery; H Sarles; Alain De Caro
Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein.
The Biochemical journal 1986;238(1):227-32.
1986: L Multigner; M Daudon; G Montalto; Alain De Caro; J P Etienne; H Sarles
Radiolucent pancreatic stones.
The New England journal of medicine 1986;314(4):248.
1985: H Sarles; Alain De Caro; L Multigner; Jean-Charles Dagorn
Pancreatic stone protein.
Digestive diseases and sciences 1985;30(9):905.
1985: D Giorgi; J P Bernard; Alain De Caro; L Multigner; R Lapointe; H Sarles; Jean-Charles Dagorn
Pancreatic stone protein. I. Evidence that it is encoded by a pancreatic messenger ribonucleic acid.
Gastroenterology 1985;89(2):381-6.
1985: L Multigner; H Sarles; D Lombardo; Alain De Caro
Pancreatic stone protein. II. Implication in stone formation during the course of chronic calcifying pancreatitis.
Gastroenterology 1985;89(2):387-91.
1985: G Montalto; M Lusher; Alain De Caro; L Multigner; H Sarles; M Delaage
[Monoclonal antibody analysis of human pancreatic juice components related to the pancreatic calculi protein].
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1985;300(6):199-202.
1984: Alain De Caro; L Multigner; H Lafont; D Lombardo; H Sarles
The molecular characteristics of a human pancreatic acidic phosphoprotein that inhibits calcium carbonate crystal growth.
The Biochemical journal 1984;222(3):669-77.
1984: D Campese; D Lombardo; L Multigner; H Lafont; Alain De Caro
Implication of a tyrosine residue in the unspecific bile salt binding site of human pancreatic carboxylic ester hydrolase.
Biochimica et biophysica acta 1984;784(2-3):147-57.
1984: G Montalto; L Multigner; H Sarles; Alain De Caro
[Protein inhibitors of crystallization. Their characterization and potential role in calcium lithiasis].
Néphrologie 1984;5(4):155-7.
1984: Francoise Senegas-Balas; Daniel Balas; Robert Verger; Alain De Caro; C Figarella; Francine Ferrato; P Lechene; C Bertrand; A Ribet
Immunohistochemical localization of intestinal phospholipase A2 in rat paneth cells.
Histochemistry 1984;81(6):581-4.
1983: D Lombardo; D Campese; L Multigner; H Lafont; Alain De Caro
On the probable involvement of arginine residues in the bile-salt-binding site of human pancreatic carboxylic ester hydrolase.
European journal of biochemistry / FEBS 1983;133(2):327-33.
1983: L Multigner; Alain De Caro; D Lombardo; D Campese; H Sarles
Pancreatic stone protein, a phosphoprotein which inhibits calcium carbonate precipitation from human pancreatic juice.
Biochemical and biophysical research communications 1983;110(1):69-74.
1983: H Sarles; Alain De Caro; L Multigner; D Campese; D Lombardo
[Chronic calcifying pancreatitis: an anatomopathological reality has arrived at the molecular stage of knowledge].
Gastroentérologie clinique et biologique 1983;7(1):4-7.
1982: Alain De Caro; L Multigner; H Vérine
Identification of two major proteins of bovine pancreatic stones as immunoreactive forms of trypsinogens.
The Biochemical journal 1982;205(3):543-9.
1981: Alain De Caro; J Bonicel; G Pieroni; O Guy
Comparative studies of human and porcine pancreatic lipases : N-terminal sequences, sulfhydryl groups and interfacial activity.
Biochimie 1981;63(10):799-801.
1981: R Grataroli; Alain De Caro; O Guy; J Amic; Catherine Figarella
Isolation and properties of prophospholipase A2 from human pancreatic juice.
Biochimie 1981;63(8-9):677-84.
1980: H Sarles; Catherine Figarella; O Tiscornia; E Colomb; O Guy; H Verine; Alain De Caro; L Multigner; P Lechene
Chronic calcifying pancreatitis (CCP). Mechanism of formation of the lesions. New data and critical study.
Monographs in pathology 1980;21():48-66.