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Pierre De Clercq

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Guy Eelen; Lieve Verlinden; Roger Bouillon; Pierre J De Clercq; Alberto Muñoz; Annemieke Verstuyf
CD-ring modified vitamin D3 analogs and their superagonistic action.
Els Vanoirbeek; Guy Eelen; Lieve Verlinden; Kathleen Marchal; Kristof Engelen; Bart De Moor; Ine Beullens; Suzanne Marcelis; Pierre J De Clercq; Roger Bouillon; Annemieke Verstuyf
Microarray analysis of MCF-7 breast cancer cells treated with 1,25-dihydroxyvitamin D3 or a 17-methyl-D-ring analog.
Guy Eelen; Lieve Verlinden; JM Laureys; Suzanne Marcelis; Pierre J De Clercq; Chantal Mathieu; Roger Bouillon; Annemieke Verstuyf
Antiproliferative and calcemic actions of trans-decalin CD-ring analogs of 1,25-dihydroxyvitamin D3.

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All Publications

2010: Guy Eelen; Lieve Verlinden; Roger Bouillon; Pierre J De Clercq; Alberto Muñoz; Annemieke Verstuyf
CD-ring modified vitamin D3 analogs and their superagonistic action.
The Journal of steroid biochemistry and molecular biology 2010;121(1-2):417-9.
2009: Els Vanoirbeek; Guy Eelen; Lieve Verlinden; Kathleen Marchal; Kristof Engelen; Bart De Moor; Ine Beullens; Suzanne Marcelis; Pierre J De Clercq; Roger Bouillon; Annemieke Verstuyf
Microarray analysis of MCF-7 breast cancer cells treated with 1,25-dihydroxyvitamin D3 or a 17-methyl-D-ring analog.
Anticancer research 2009;29(9):3585-90.
2009: Guy Eelen; Lieve Verlinden; JM Laureys; Suzanne Marcelis; Pierre J De Clercq; Chantal Mathieu; Roger Bouillon; Annemieke Verstuyf
Antiproliferative and calcemic actions of trans-decalin CD-ring analogs of 1,25-dihydroxyvitamin D3.
Anticancer research 2009;29(9):3579-84.
2008: Guy Eelen; Noelia Valle; Yoshiteru Sato; Natacha Rochel; Lieve Verlinden; Pierre J De Clercq; Dino Moras; Roger Bouillon; Alberto Muñoz; Annemieke Verstuyf
Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor.
Chemistry & biology 2008;15(10):1029-34.
2008: Johan M Winne; Pierre J De Clercq; Marco Milanesio; Philip Pattison; Davide Viterbo
Nonenzymic polycyclization of analogues of oxidosqualene with a preformed C-ring.
Organic & biomolecular chemistry 2008;6(11):1918-25.
2007: G Satyanarayana Reddy; Matthew Robinson; Guochun Wang; G Tayhas R Palmore; Lynn Gennaro; Paul Vouros; Pierre J De Clercq; Maurits Vandewalle; Wu Young; Shi Ling; Annemieke Verstuyf; Roger Bouillon
Removal of C-ring from the CD-ring skeleton of 1alpha,25-dihydroxyvitamin D3 does not alter its target tissue metabolism significantly.
Archives of biochemistry and biophysics 2007;460(2):254-61.
2007: Pierre J De Clercq; Frederik De Buysser; Garrett Minne; Wim Schepens; Freek Vrielynck; Dirk Van Haver; Maurits Vandewalle; Annemieke Verstuyf; Roger Bouillon
The development of CD-ring modified analogs of 1alpha,25-dihydroxyvitamin D.
The Journal of steroid biochemistry and molecular biology 2007;103(3-5):206-12.
2007: Freek A Vrielynck; Pierre J De Clercq
Asymmetric synthesis of the epimeric (3S)-3-((E)-hex-1-enyl)-2-methylcyclohexanones.
Molecules (Basel, Switzerland) 2007;12(2):237-44.
2007: Garrett B Minne; Pierre J De Clercq
Synthesis of 3,4,7,8-tetrahydronaphthalene-1,5(2H,6H)-dione.
Molecules (Basel, Switzerland) 2007;12(2):183-7.
2007: Guy Eelen; Conny Gysemans; Lieve Verlinden; E Vanoirbeek; Pierre J De Clercq; Dirk Van Haver; Chantal Mathieu; Roger Bouillon; Annemieke Verstuyf
Mechanism and potential of the growth-inhibitory actions of vitamin D and ana-logs.
Current medicinal chemistry 2007;14(17):1893-910.
2006: Johan M Winne; Bing Guang; Jo D'Herde; Pierre J De Clercq
Application of the B-alkyl suzuki-miyaura cross-coupling reaction to the stereoselective synthesis of analogues of (3S)-oxidosqualene.
Organic letters 2006;8(21):4815-8.
2006: Wim Schepens; Dirk Van Haver; Maurits Vandewalle; Roger Bouillon; Annemieke Verstuyf; Pierre J De Clercq
Synthesis of spiro[4.5]decane CF-ring analogues of 1 alpha,25-dihydroxyvitamin D3.
Organic letters 2006;8(19):4247-50.
2006: Guy Eelen; Lieve Verlinden; Pierre J De Clercq; Maurits Vandewalle; Roger Bouillon; Annemieke Verstuyf
Vitamin D analogs and coactivators.
Anticancer research 2006;26(4A):2717-21.
2006: Samuël Demin; Dirk Van Haver; Pierre J De Clercq
Asymmetric synthesis of (7aS)-7a-methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and useful derivatives thereof.
Molecules (Basel, Switzerland) 2006;11(9):707-13.
2006: Jo N D'herde; Pierre J De Clercq
Application of the solid-phase Julia-Lythgoe olefination in vitamin D side-chain construction.
Molecules (Basel, Switzerland) 2006;11(8):655-60.
2005: Roger Bouillon; Lieve Verlinden; Guy Eelen; Pierre J De Clercq; Maurits Vandewalle; Chantal Mathieu; Annemieke Verstuyf
Mechanisms for the selective action of Vitamin D analogs.
The Journal of steroid biochemistry and molecular biology 2005;97(1-2):21-30.
2005: Guy Eelen; Lieve Verlinden; Mark Van Camp; Frank Claessens; Pierre J De Clercq; Maurits Vandewalle; Roger Bouillon; Annemieke Verstuyf
Altered Vitamin D receptor-coactivator interactions reflect superagonism of Vitamin D analogs.
The Journal of steroid biochemistry and molecular biology 2005;97(1-2):65-8.
2005: Guy Eelen; Lieve Verlinden; Natacha Rochel; Frank Claessens; Pierre J De Clercq; Maurits Vandewalle; Giuseppe Tocchini-Valentini; Dino Moras; Roger Bouillon; Annemieke Verstuyf
Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction.
Molecular pharmacology 2005;67(5):1566-73.
2005: Petra De Haes; Marjan Garmyn; Annemieke Verstuyf; Pierre J De Clercq; Maurits Vandewalle; Hugo Degreef; Katleen Vantieghem; Roger Bouillon; Siegfried Segaert
1,25-Dihydroxyvitamin D3 and analogues protect primary human keratinocytes against UVB-induced DNA damage.
Journal of photochemistry and photobiology. B, Biology 2005;78(2):141-8.
2004: Wim Schepens; Dirk Van Haver; Maurits Vandewalle; Pierre J De Clercq; Roger Bouillon; Annemieke Verstuyf
Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1alpha,25-dihydroxyvitamin D3: spiro[5.5]undecane CF-ring analogues.
Bioorganic & medicinal chemistry letters 2004;14(15):3889-92.
2004: Samuël Demin; Dirk Van Haver; Maurits Vandewalle; Pierre J De Clercq; Roger Bouillon; Annemieke Verstuyf
Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1alpha,25-dihydroxyvitamin D3: cis-perhydrindane CE-ring analogues.
Bioorganic & medicinal chemistry letters 2004;14(15):3885-8.
2004: Pierre J De Clercq; Ibrahim Murad; Ling-Jie Gao; Yong-Jun Chen; Dirk Van Haver; Maurits Vandewalle; Annemieke Verstuyf; Lieve Verlinden; Christel Verboven; Roger Bouillon
Biological activity and conformational analysis of C20 and C14 epimers of CD-ring modified trans-decalin 1alpha,25-dihydroxyvitamin D analogs.
The Journal of steroid biochemistry and molecular biology 2004;89-90(1-5):61-6.
2004: Petra De Haes; Marjan Garmyn; Annemieke Verstuyf; Pierre J De Clercq; Maurits Vandewalle; Katleen Vantieghem; Hugo Degreef; Roger Bouillon; Siegfried Segaert
Two 14-epi analogues of 1,25-dihydroxyvitamin D3 protect human keratinocytes against the effects of UVB.
Archives of dermatological research 2004;295(12):527-34.
2003: Lieve Verlinden; Annemieke Verstuyf; Christel Verboven; Guy Eelen; Camiel J De Ranter; Ling-Jie Gao; Yong-Jun Chen; Ibrahim Murad; Mihwa Choi; Keiko Yamamoto; Sachiko Yamada; Dirk Van Haver; Maurits Vandewalle; Pierre J De Clercq; Roger Bouillon
Previtamin D3 with a trans-fused decalin CD-ring has pronounced genomic activity.
The Journal of biological chemistry 2003;278(37):35476-82.
2003: Yong-Jun Chen; Ling-Jie Gao; Ibrahim Murad; Annemieke Verstuyf; Lieve Verlinden; Christel Verboven; Roger Bouillon; Davide Viterbo; Marco Milanesio; Dirk Van Haver; Maurits Vandewalle; Pierre J De Clercq
Synthesis, biological activity, and conformational analysis of CD-ring modified trans-decalin 1 alpha,25-dihydroxyvitamin D analogs.
Organic & biomolecular chemistry 2003;1(2):257-67.
2002: Annemieke Madder; Liu Li; Hilde De Muynck; Nadia Farcy; Dirk Van Haver; Franky Fant; Gerd Vanhoenacker; Pat Sandra; Anthony P Davis; Pierre J De Clercq
Evaluation of a two-stage screening procedure in the combinatorial search for serine protease-like activity.
Journal of combinatorial chemistry 2002;4(6):552-62.
2002: Ling-Jie Gao; Magali Waelbroeck; Sven Hofman; Dirk Van Haver; Marco Milanesio; Davide Viterbo; Pierre J De Clercq
Synthesis and affinity studies of himbacine derived muscarinic receptor antagonists.
Bioorganic & medicinal chemistry letters 2002;12(15):1909-12.
2002: Yusheng Wu; Pierre J De Clercq; Maurits Vandewalle; Roger Bouillon; Annemieke Verstuyf
Vitamin D(3): synthesis of seco-C-9,11-bisnor-17-methyl-1 alpha,25-dihydroxyvitamin D(3) analogues.
Bioorganic & medicinal chemistry letters 2002;12(12):1633-6.
2002: Yusheng Wu; Katrien Sabbe; Pierre J De Clercq; Maurits Vandewalle; Roger Bouillon; Annemieke Verstuyf
Vitamin D(3): synthesis of seco C-9,11,21-trisnor-17-methyl-1 alpha, 25-dihydroxyvitamin D(3) analogues.
Bioorganic & medicinal chemistry letters 2002;12(12):1629-32.
2002: Gunther Van Cauwenberge; Ling-Jie Gao; Dirk Van Haver; Marco Milanesio; Davide Viterbo; Pierre J De Clercq
A novel short convergent entry into himbacine derivatives.
Organic letters 2002;4(9):1579-82.
2001: N Farcy; H De Muynck; Annemieke Madder; N Hosten; Pierre J De Clercq
A pentaerythritol-based molecular scaffold for solid-phase combinatorial chemistry.
Organic letters 2001;3(26):4299-301.
2001: Lieve Verlinden; Annemieke Verstuyf; Marcus Quack; Mark Van Camp; Evelyne van Etten; Pierre J De Clercq; Maurits Vandewalle; Carsten Carlberg; Roger Bouillon
Interaction of two novel 14-epivitamin D3 analogs with vitamin D3 receptor-retinoid X receptor heterodimers on vitamin D3 responsive elements.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(4):625-38.
2001: S Gabriëls; Dirk Van Haver; Maurits Vandewalle; Pierre J De Clercq; Annemieke Verstuyf; Roger Bouillon
Development of analogues of 1alpha,25-dihydroxyvitamin D3 with biased side chain orientation: methylated des-C,D-homo analogues.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(2):520-32.
2000: Lieve Verlinden; Annemieke Verstuyf; Mark Van Camp; S Marcelis; Katrien Sabbe; X Y Zhao; Pierre J De Clercq; Maurits Vandewalle; Roger Bouillon
Two novel 14-Epi-analogues of 1,25-dihydroxyvitamin D3 inhibit the growth of human breast cancer cells in vitro and in vivo.
Cancer research 2000;60(10):2673-9.
2000: Annemieke Verstuyf; Lieve Verlinden; Evelyne van Etten; L Shi; Y Wu; C D'Halleweyn; Dirk Van Haver; G D Zhu; Yong-Jun Chen; X Zhou; M R Haussler; Pierre J De Clercq; Maurits Vandewalle; Hugo Van Baelen; Chantal Mathieu; Roger Bouillon
Biological activity of CD-ring modified 1alpha,25-dihydroxyvitamin D analogues: C-ring and five-membered D-ring analogues.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(2):237-52.
1999: X Zhou; G D Zhu; Dirk Van Haver; Maurits Vandewalle; Pierre J De Clercq; Annemieke Verstuyf; Roger Bouillon
Synthesis, biological activity, and conformational analysis of four seco-D-15,19-bisnor-1alpha,25-dihydroxyvitamin D analogues, diastereomeric at C17 and C20.
Journal of medicinal chemistry 1999;42(18):3539-56.
1998: Dirk Van Haver; Pierre J De Clercq
On the use of volume maps in the conformational analysis of vitamin D analogs.
Bioorganic & medicinal chemistry letters 1998;8(9):1029-34.
1998: Annemieke Verstuyf; Lieve Verlinden; Hugo Van Baelen; Katrien Sabbe; C D'Hallewyn; Pierre J De Clercq; Maurits Vandewalle; Roger Bouillon
The biological activity of nonsteroidal vitamin D hormone analogs lacking both the C- and D-rings.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(4):549-58.