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Benoit de Crombrugghe

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Wook-Young Baek; Benoit de Crombrugghe; Young-Ji Kim; Jung-Eun Kim
Osterix is required for cranial neural crest-derived craniofacial bone formation.
Qin Chen; Wenbin Liu; Krishna M Sinha; Hideyo Yasuda; Benoit de Crombrugghe
Identification and characterization of microRNAs controlled by the osteoblast-specific transcription factor Osterix.
Stephen P Henry; Shoudan Liang; Kadir C Akdemir; Benoit de Crombrugghe
The postnatal role of Sox9 in cartilage.

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2013: Wook-Young Baek; Benoit de Crombrugghe; Young-Ji Kim; Jung-Eun Kim
Osterix is required for cranial neural crest-derived craniofacial bone formation.
Biochemical and biophysical research communications 2013;432(1):188-92.
2013: Qin Chen; Wenbin Liu; Krishna M Sinha; Hideyo Yasuda; Benoit de Crombrugghe
Identification and characterization of microRNAs controlled by the osteoblast-specific transcription factor Osterix.
PloS one 2013;8(3):e58104.
2012: Stephen P Henry; Shoudan Liang; Kadir C Akdemir; Benoit de Crombrugghe
The postnatal role of Sox9 in cartilage.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012;27(12):2511-25.
2012: Christian Beyer; Benoit de Crombrugghe; Clara Dees; Oliver Distler; Kolja Gelse; Trayana Kireva; Georg Schett; Amelie Schramm; Sonali Sonnylal; Makoto Mark Taketo; Alfiya Akhmetshina; Jörg H W Distler
β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis.
Annals of the rheumatic diseases 2012;71(5):761-7.
2012: Zhengguo Cao; Benoit de Crombrugghe; Tian Gao; Xianglong Han; Yinshi Ren; Martha J Somerman; Yin Xiao; Hua Zhang; Xin Zhou; Jian Q Feng
Genetic evidence for the vital function of Osterix in cementogenesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012;27(5):1080-92.
2012: Chi Zhang; Hui Dai; Benoit de Crombrugghe
Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx.
Biochemical and biophysical research communications 2012;420(4):782-6.
2012: Jung-Hoon Oh; Seung-Yoon Park; Benoit de Crombrugghe; Jung-Eun Kim
Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification.
Biochemical and biophysical research communications 2012;418(4):634-40.
2012: Wanjin Tang; Guozhi Xiao; Fan Yang; Benoit de Crombrugghe; Hongli Jiao; Yang Li; Chi Zhang
Transcriptional regulation of Vascular Endothelial Growth Factor (VEGF) by osteoblast-specific transcription factor Osterix (Osx) in osteoblasts.
The Journal of biological chemistry 2012;287(3):1671-8.
2011: Jiu-Cun Wang; F C Arnett; Benoit de Crombrugghe; S Sonnylal; Xiaodong Zhou
Attenuation of expression of extracellular matrix genes with siRNAs to Sparc and Ctgf in skin fibroblasts of CTGF transgenic mice.
International journal of immunopathology and pharmacology 2011;24(3):595-601.
2010: Jane Y Dancer; Stephen P Henry; Jolanta Bondaruk; Sangkyou Lee; Alberto G Ayala; Benoit de Crombrugghe; Bogdan Czerniak
Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors.
Human pathology 2010;41(12):1788-93.
2010: Tsunemitsu Soeda; Jian Min Deng; Benoit de Crombrugghe; Richard R Behringer; Takashi Nakamura; Haruhiko Akiyama
Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons.
Genesis (New York, N.Y. : 2000) 2010;48(11):635-44.
2010: Fan Yang; Wanjin Tang; Sarah So; Benoit de Crombrugghe; Chi Zhang
Sclerostin is a direct target of osteoblast-specific transcription factor osterix.
Biochemical and biophysical research communications 2010;400(4):684-8.
2010: Françoise Coustry; Chun-Do Oh; Takako Hattori; Sankar N Maity; Benoit de Crombrugghe; Hideyo Yasuda
The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template.
Nucleic acids research 2010;38(18):6018-28.
2010: Xin Zhou; Zhaoping Zhang; Jian Q Feng; Vladmir M Dusevich; Krishna Sinha; Hua Zhang; Bryant G Darnay; Benoit de Crombrugghe
Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(29):12919-24.
2010: Sonali Sonnylal; Xu Shi-wen; Patricia Leoni; Katherine Naff; Carolyn S Van Pelt; Hiroyuki Nakamura; Andrew Leask; David Abraham; George Bou-Gharios; Benoit de Crombrugghe
Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.
Arthritis and rheumatism 2010;62(5):1523-32.
2010: Wook-Young Baek; Benoit de Crombrugghe; Jung-Eun Kim
Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance.
Bone 2010;46(4):920-8.
2010: Takako Hattori; Catharina Müller; Sonja Gebhard; Eva Bauer; Friederike Pausch; Britta Schlund; Michael R Bösl; Andreas Hess; Cordula Surmann-Schmitt; Helga von der Mark; Benoit de Crombrugghe; Klaus von der Mark
SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification.
Development (Cambridge, England) 2010;137(6):901-11.
2010: Krishna M Sinha; Hideyo Yasuda; Madelene M Coombes; Sharon Y R Dent; Benoit de Crombrugghe
Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase.
The EMBO journal 2010;29(1):68-79.
2010: Chun-Do Oh; Sankar N Maity; Jing-Fang Lu; Jiexin Zhang; Shoudan Liang; Francoise Coustry; Benoit de Crombrugghe; Hideyo Yasuda
Identification of SOX9 interaction sites in the genome of chondrocytes.
PloS one 2010;5(4):e10113.
2010: Jiu-Cun Wang; Syeling Lai; Xinjian Guo; Xuefeng Zhang; Benoit de Crombrugghe; Sonali Sonnylal; Frank C Arnett; Xiaodong Zhou
Attenuation of fibrosis in vitro and in vivo with SPARC siRNA.
Arthritis research & therapy 2010;12(2):R60.
2010: Magaly Martinez-Ferrer; Ali-Reza Afshar-Sherif; Consolate Uwamariya; Benoit de Crombrugghe; Jeffrey M Davidson; Neil A Bhowmick
Dermal transforming growth factor-beta responsiveness mediates wound contraction and epithelial closure.
The American journal of pathology 2010;176(1):98-107.
2009: Stephen P Henry; Chuan-Wei Jang; Jian Min Deng; Zhaoping Zhang; Richard R Behringer; Benoit de Crombrugghe
Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage.
Genesis (New York, N.Y. : 2000) 2009;47(12):805-14.
2009: Jian Luo; Wei Zhou; Xin Zhou; Dali Li; Jinsheng Weng; Zhengfang Yi; Sung Gook Cho; Chenghai Li; Tingfang Yi; Xiushan Wu; Xiao-Ying Li; Benoit de Crombrugghe; Magnus Höök; Mingyao Liu
Regulation of bone formation and remodeling by G-protein-coupled receptor 48.
Development (Cambridge, England) 2009;136(16):2747-56.
2009: Wook-Young Baek; Min-A Lee; Ji Won Jung; Shin-Yoon Kim; Haruhiko Akiyama; Benoit de Crombrugghe; Jung-Eun Kim
Positive regulation of adult bone formation by osteoblast-specific transcription factor osterix.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(6):1055-65.
2009: Hideyo Yasuda; Benoit de Crombrugghe
Joint formation requires muscle formation and contraction.
Developmental cell 2009;16(5):625-6.
2008: Sonja Gebhard; Takako Hattori; Eva Bauer; Britta Schlund; Michael R Bösl; Benoit de Crombrugghe; Klaus von der Mark
Specific expression of Cre recombinase in hypertrophic cartilage under the control of a BAC-Col10a1 promoter.
Matrix biology : journal of the International Society for Matrix Biology 2008;27(8):693-9.
2008: Chi Zhang; Kyucheol Cho; Y Huang; Jon P Lyons; Xin Zhou; Krishna Sinha; Pierre D McCrea; Benoit de Crombrugghe
Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(19):6936-41.
2008: Takako Hattori; Francoise Coustry; Shelley Stephens; Heidi Eberspaecher; Masaharu Takigawa; Hideyo Yasuda; Benoit de Crombrugghe
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5.
Nucleic acids research 2008;36(9):3011-24.
2008: Hiroaki Kimura; Kin Ming Kwan; Zhaoping Zhang; Jian Min Deng; Bryant G Darnay; Richard R Behringer; Takashi Nakamura; Benoit de Crombrugghe; Haruhiko Akiyama
Cthrc1 is a positive regulator of osteoblastic bone formation.
PloS one 2008;3(9):e3174.
2008: Ying Cao; Shu-Fang Jia; Geetika Chakravarty; Benoit de Crombrugghe; Eugenie S Kleinerman
The osterix transcription factor down-regulates interleukin-1 alpha expression in mouse osteosarcoma cells.
Molecular cancer research : MCR 2008;6(1):119-26.
2007: Yuko Mori-Akiyama; Maaike van den Born; Johan H van Es; Stanley R Hamilton; Henry P Adams; Jiexin Zhang; Hans Clevers; Benoit de Crombrugghe
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium.
Gastroenterology 2007;133(2):539-46.
2007: Hiroaki Kimura; Haruhiko Akiyama; Takashi Nakamura; Benoit de Crombrugghe
Tenascin-W inhibits proliferation and differentiation of preosteoblasts during endochondral bone formation.
Biochemical and biophysical research communications 2007;356(4):935-41.
2007: Haruhiko Akiyama; H Scott Stadler; James F Martin; Takahiro M Ishii; Philip A Beachy; Takashi Nakamura; Benoit de Crombrugghe
Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice.
Matrix biology : journal of the International Society for Matrix Biology 2007;26(4):224-33.
2007: Sonja Gebhard; Takako Hattori; Eva Bauer; Michael R Bösl; Britta Schlund; Ernst Pöschl; Nadia Adam; Benoit de Crombrugghe; Klaus von der Mark
BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter.
Histochemistry and cell biology 2007;127(2):183-94.
2007: Sonali Sonnylal; Christopher P Denton; Bing Zheng; Douglas R Keene; Ruming He; Henry P Adams; Carolyn S Vanpelt; Yong J Geng; Jian Min Deng; Richard R Behringer; Benoit de Crombrugghe
Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma.
Arthritis and rheumatism 2007;56(1):334-44.
2006: Martina Schmidl; Nadia Adam; Cordula Surmann-Schmitt; Takako Hattori; Michael Stock; Uwe Dietz; Benoit de Crombrugghe; Ernst Pöschl; Klaus von der Mark
Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo.
The Journal of biological chemistry 2006;281(42):31790-800.
2006: Stuart H Ralston; Benoit de Crombrugghe
Genetic regulation of bone mass and susceptibility to osteoporosis.
Genes & development 2006;20(18):2492-506.
2006: Takako Hattori; Heidi Eberspaecher; Jingfang Lu; Ren Zhang; Tamotsu Nishida; Tomoaki Kahyo; Hideyo Yasuda; Benoit de Crombrugghe
Interactions between PIAS proteins and SOX9 result in an increase in the cellular concentrations of SOX9.
The Journal of biological chemistry 2006;281(20):14417-28.
2006: Ren Zhang; Shunichi Murakami; Françoise Coustry; Ying Wang; Benoit de Crombrugghe
Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(2):365-70.
2006: Xueying Wang; Hui-Yi Kua; Yuanyu Hu; Ke Guo; Qi Zeng; Qiang Wu; Huck-Hui Ng; Gerard Karsenty; Benoit de Crombrugghe; James Yeh; Baojie Li
p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling.
The Journal of cell biology 2006;172(1):115-25.
2005: Haruhiko Akiyama; Jung-Eun Kim; Kazuhisa Nakashima; Gener Balmes; Naomi Iwai; Jian Min Deng; Zhaoping Zhang; James F Martin; Richard R Behringer; Takashi Nakamura; Benoit de Crombrugghe
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(41):14665-70.
2005: Benoit de Crombrugghe
Osteoblasts clock in for their day job.
Cell 2005;122(5):651-3.
2005: Takako Koga; Yuichi Matsui; Masataka Asagiri; Tatsuhiko Kodama; Benoit de Crombrugghe; Kazuhisa Nakashima; Hiroshi Takayanagi
NFAT and Osterix cooperatively regulate bone formation.
Nature medicine 2005;11(8):880-5.
2005: Ying Cao; Zhichao Zhou; Benoit de Crombrugghe; Kazuhisa Nakashima; Hui Guan; Xiaoping Duan; Shu-Fang Jia; Eugenie S Kleinerman
Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma.
Cancer research 2005;65(4):1124-8.
2005: Haruhiko Akiyama; Tetsu Kamitani; Xiaohong Yang; Roshini Kandyil; Laura C Bridgewater; Marc Fellous; Yuko Mori-Akiyama; Benoit de Crombrugghe
The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site.
Matrix biology : journal of the International Society for Matrix Biology 2005;23(8):499-505.
2005: Takako Hattori; Klaus von der Mark; Harumi Kawaki; Yasutaka Yutani; Satoshi Kubota; Tohru Nakanishi; Heidi Eberspaecher; Benoit de Crombrugghe; Masaharu Takigawa
Downregulation of rheumatoid arthritis-related antigen RA-A47 (HSP47/colligin-2) in chondrocytic cell lines induces apoptosis and cell-surface expression of RA-A47 in association with CD9.
Journal of cellular physiology 2005;202(1):191-204.
2004: Jung-Eun Kim; Kazuhisa Nakashima; Benoit de Crombrugghe
Transgenic mice expressing a ligand-inducible cre recombinase in osteoblasts and odontoblasts: a new tool to examine physiology and disease of postnatal bone and tooth.
The American journal of pathology 2004;165(6):1875-82.
2004: Sonja Gebhard; Ernst Pöschl; Silvia Riemer; Eva Bauer; Takako Hattori; Heidi Eberspaecher; Zhaoping Zhang; Veronique Lefebvre; Benoit de Crombrugghe; Klaus von der Mark
A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo.
Matrix biology : journal of the International Society for Matrix Biology 2004;23(5):309-22.
2004: Haruhiko Akiyama; Jon P Lyons; Yuko Mori-Akiyama; Xiaohong Yang; Ren Zhang; Zhaoping Zhang; Jian Min Deng; Makoto M Taketo; Takashi Nakamura; Richard R Behringer; Pierre D McCrea; Benoit de Crombrugghe
Interactions between Sox9 and beta-catenin control chondrocyte differentiation.
Genes & development 2004;18(9):1072-87.
2004: Haruhiko Akiyama; Marie-Christine Chaboissier; Richard R Behringer; David H Rowitch; Andreas Schedl; Jonathan A Epstein; Benoit de Crombrugghe
Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6502-7.
2004: Shunichi Murakami; Gener Balmes; Sandra McKinney; Zhaoping Zhang; David Givol; Benoit de Crombrugghe
Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype.
Genes & development 2004;18(3):290-305.
2003: Anuradha Bhattacharya; Jian Min Deng; Zhaoping Zhang; Richard R Behringer; Benoit de Crombrugghe; SANKAR MAITY
The B subunit of the CCAAT box binding transcription factor complex (CBF/NF-Y) is essential for early mouse development and cell proliferation.
Cancer research 2003;63(23):8167-72.
2003: Christos Chadjichristos; Chafik Ghayor; Magdalini Kypriotou; Grégoire Martin; Emmanuelle Renard; Leena Ala-Kokko; Gunthram Suske; Benoit de Crombrugghe; Jean-Pierre Pujol; Philippe Galéra
Sp1 and Sp3 transcription factors mediate interleukin-1 beta down-regulation of human type II collagen gene expression in articular chondrocytes.
The Journal of biological chemistry 2003;278(41):39762-72.
2003: Yutaka Inagaki; Tomoyuki Nemoto; Miwa Kushida; Yin Sheng; Kiyoshi Higashi; Kazuo Ikeda; Norifumi Kawada; Fumiaki Shirasaki; Kazuhiko Takehara; Kota Sugiyama; Mitsukiyo Fujii; Hiroshi Yamauchi; Atsuhito Nakao; Benoit de Crombrugghe; Tetsu Watanabe; Isao Okazaki
Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice.
Hepatology (Baltimore, Md.) 2003;38(4):890-9.
2003: Takako Hattori; Harumi Kawaki; Satoshi Kubota; Yasutaka Yutani; Benoit de Crombrugghe; Klaus von der Mark; Masaharu Takigawa
Downregulation of a rheumatoid arthritis-related antigen (RA-A47) by ra-a47 antisense oligonucleotides induces inflammatory factors in chondrocytes.
Journal of cellular physiology 2003;197(1):94-102.
2003: Yuko Mori-Akiyama; Haruhiko Akiyama; David H Rowitch; Benoit de Crombrugghe
Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9360-5.
2003: Kazuhisa Nakashima; Benoit de Crombrugghe
Transcriptional mechanisms in osteoblast differentiation and bone formation.
Trends in genetics : TIG 2003;19(8):458-66.
2003: Christopher P Denton; Bing Zheng; Lowri A Evans; Xu Shi-wen; Voon H Ong; Ivan B Fisher; Konstantinos Lazaridis; David J Abraham; Carol M Black; Benoit de Crombrugghe
Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice.
The Journal of biological chemistry 2003;278(27):25109-19.
2003: Bret Michael Wehrli; Wendong Huang; Benoit de Crombrugghe; Alberto G Ayala; Bogdan Czerniak
Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors.
Human pathology 2003;34(3):263-9.
2003: Laura C Bridgewater; Marlan D Walker; Gwen C Miller; Trevor A Ellison; L Daniel Holsinger; Jennifer L Potter; Todd L Jackson; Reuben K Chen; Vicki L Winkel; Zhaoping Zhang; Sandra McKinney; Benoit de Crombrugghe
Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements.
Nucleic acids research 2003;31(5):1541-53.
2003: Magdalini Kypriotou; Magali Fossard-Demoor; Christos Chadjichristos; Chafik Ghayor; Benoit de Crombrugghe; Jean-Pierre Pujol; Philippe Galéra
SOX9 exerts a bifunctional effect on type II collagen gene (COL2A1) expression in chondrocytes depending on the differentiation state.
DNA and cell biology 2003;22(2):119-29.
2002: Wendong Huang; Ni Lu; Heidi Eberspaecher; Benoit de Crombrugghe
A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene.
The Journal of biological chemistry 2002;277(52):50668-75.
2002: Haruhiko Akiyama; Marie-Christine Chaboissier; James F Martin; Andreas Schedl; Benoit de Crombrugghe
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.
Genes & development 2002;16(21):2813-28.
2002: Bing Zheng; Zhaoping Zhang; Carol M Black; Benoit de Crombrugghe; Christopher P Denton
Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis.
The American journal of pathology 2002;160(5):1609-17.
2002: Takuro Kinbara; Fumiaki Shirasaki; Shigeru Kawara; Yutaka Inagaki; Benoit de Crombrugghe; Kazuhiko Takehara
Transforming growth factor-beta isoforms differently stimulate proalpha2 (I) collagen gene expression during wound healing process in transgenic mice.
Journal of cellular physiology 2002;190(3):375-81.
2002: Kazuhisa Nakashima; Xin Zhou; Gary Kunkel; Zhaoping Zhang; Jian Min Deng; Richard R Behringer; Benoit de Crombrugghe
The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation.
Cell 2002;108(1):17-29.
2001: Benoit de Crombrugghe; Veronique Lefebvre; K Nakashima
Regulatory mechanisms in the pathways of cartilage and bone formation.
Current opinion in cell biology 2001;13(6):721-7.
2001: Françoise Coustry; Qianghua Hu; Benoit de Crombrugghe; SANKAR MAITY
CBF/NF-Y functions both in nucleosomal disruption and transcription activation of the chromatin-assembled topoisomerase IIalpha promoter. Transcription activation by CBF/NF-Y in chromatin is dependent on the promoter structure.
The Journal of biological chemistry 2001;276(44):40621-30.
2001: P Smits; P Li; J Mandel; Zhen Zhang; Jian Min Deng; Richard R Behringer; Benoit de Crombrugghe; Veronique Lefebvre
The transcription factors L-Sox5 and Sox6 are essential for cartilage formation.
Developmental cell 2001;1(2):277-90.
2001: Taras T Antoniv; Sarah De Val; D Wells; C P Denton; C Rabe; Benoit de Crombrugghe; Francesco Ramirez; George Bou-Gharios
Characterization of an evolutionarily conserved far-upstream enhancer in the human alpha 2(I) collagen (COL1A2) gene.
The Journal of biological chemistry 2001;276(24):21754-64.
2001: W Bi; Wendong Huang; Deanne J Whitworth; Jian Min Deng; Zhen Zhang; Richard R Behringer; Benoit de Crombrugghe
Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6698-703.
2001: S P Henry; M Takanosu; T C Boyd; P M Mayne; Heidi Eberspaecher; W Zhou; Benoit de Crombrugghe; M Hook; Richard Mayne
Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family.
The Journal of biological chemistry 2001;276(15):12212-21.
2001: Christopher P Denton; B Zheng; Xu Shiwen; Zhen Zhang; George Bou-Gharios; Heidi Eberspaecher; Carol M Black; Benoit de Crombrugghe
Activation of a fibroblast-specific enhancer of the proalpha2(I) collagen gene in tight-skin mice.
Arthritis and rheumatism 2001;44(3):712-22.
2001: Wendong Huang; U I Chung; H M Kronenberg; Benoit de Crombrugghe
The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):160-5.
2001: Veronique Lefebvre; Richard R Behringer; Benoit de Crombrugghe
L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9 Suppl A():S69-75.
2001: Wendong Huang; S L Wang; Guillermina Lozano; Benoit de Crombrugghe
cDNA library screening using the SOS recruitment system.
BioTechniques 2001;30(1):94-8, 100.
2000: Benoit de Crombrugghe; Veronique Lefebvre; Richard R Behringer; W Bi; Shunichi Murakami; Wendong Huang
Transcriptional mechanisms of chondrocyte differentiation.
Matrix biology : journal of the International Society for Matrix Biology 2000;19(5):389-94.
2000: Wendong Huang; X Zhou; Veronique Lefebvre; Benoit de Crombrugghe
Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer.
Molecular and cellular biology 2000;20(11):4149-58.
2000: Shunichi Murakami; Veronique Lefebvre; Benoit de Crombrugghe
Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha.
The Journal of biological chemistry 2000;275(5):3687-92.
2000: Shunichi Murakami; M Kan; Wallace L McKeehan; Benoit de Crombrugghe
Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1113-8.
1999: W Bi; Jian Min Deng; Zhen Zhang; Richard R Behringer; Benoit de Crombrugghe
Sox9 is required for cartilage formation.
Nature genetics 1999;22(1):85-9.
1999: Maria Concetta Faniello; Maria Assunta Bevilacqua; G Condorelli; Benoit de Crombrugghe; SANKAR MAITY; Vittorio E Avvedimento; Filiberto Cimino; Francesco Costanzo
The B subunit of the CAAT-binding factor NFY binds the central segment of the Co-activator p300.
The Journal of biological chemistry 1999;274(12):7623-6.
1998: Veronique Lefebvre; P Li; Benoit de Crombrugghe
A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene.
The EMBO journal 1998;17(19):5718-33.
1998: Y Inagaki; S Truter; George Bou-Gharios; Lee Ann Garrett-Sinha; Benoit de Crombrugghe; T Nemoto; P Greenwel
Activation of Proalpha2(I) collagen promoter during hepatic fibrogenesis in transgenic mice.
Biochemical and biophysical research communications 1998;250(3):606-11.
1998: Laura C Bridgewater; Veronique Lefebvre; Benoit de Crombrugghe
Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer.
The Journal of biological chemistry 1998;273(24):14998-5006.
1998: G Zhou; Veronique Lefebvre; Zhen Zhang; Heidi Eberspaecher; Benoit de Crombrugghe
Three high mobility group-like sequences within a 48-base pair enhancer of the Col2a1 gene are required for cartilage-specific expression in vivo.
The Journal of biological chemistry 1998;273(24):14989-97.
1998: SANKAR MAITY; Benoit de Crombrugghe
Role of the CCAAT-binding protein CBF/NF-Y in transcription.
Trends in biochemical sciences 1998;23(5):174-8.
1998: Veronique Lefebvre; Benoit de Crombrugghe
Toward understanding SOX9 function in chondrocyte differentiation.
Matrix biology : journal of the International Society for Matrix Biology 1998;16(9):529-40.
1997: W Bi; L Wu; Françoise Coustry; Benoit de Crombrugghe; SANKAR MAITY
DNA binding specificity of the CCAAT-binding factor CBF/NF-Y.
The Journal of biological chemistry 1997;272(42):26562-72.
1997: S S Chen; E Cristy Ruteshouser; SANKAR MAITY; Benoit de Crombrugghe
Cell-specific in vivo DNA-protein interactions at the proximal promoters of the pro alpha 1(I) and the pro alpha2(I) collagen genes.
Nucleic acids research 1997;25(16):3261-8.
1997: Q Zhao; Heidi Eberspaecher; Veronique Lefebvre; Benoit de Crombrugghe
Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 1997;209(4):377-86.
1997: Veronique Lefebvre; Wendong Huang; VR Harley; P N Goodfellow; Benoit de Crombrugghe
SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene.
Molecular and cellular biology 1997;17(4):2336-46.
1997: T Hasegawa; A Takeuchi; O Miyaishi; K i Isobe; Benoit de Crombrugghe
Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes.
The Journal of biological chemistry 1997;272(8):4915-23.
1996: Lee Ann Garrett-Sinha; Heidi Eberspaecher; Michael F Seldin; Benoit de Crombrugghe
A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells.
The Journal of biological chemistry 1996;271(49):31384-90.
1996: S Sinha; SANKAR MAITY; Michael F Seldin; Benoit de Crombrugghe
Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor.
Genomics 1996;37(2):260-3.
1996: T Hasegawa; X Zhou; Lee Ann Garrett-Sinha; E C Ruteshouser; SANKAR MAITY; Benoit de Crombrugghe
Evidence for three major transcription activation elements in the proximal mouse proalpha2(I) collagen promoter.
Nucleic acids research 1996;24(16):3253-60.
1996: Veronique Lefebvre; G Zhou; K Mukhopadhyay; C N Smith; Zhen Zhang; Heidi Eberspaecher; X Zhou; S Sinha; SANKAR MAITY; Benoit de Crombrugghe
An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes.
Molecular and cellular biology 1996;16(8):4512-23.
1996: I S Kim; S Sinha; Benoit de Crombrugghe; SANKAR MAITY
Determination of functional domains in the C subunit of the CCAAT-binding factor (CBF) necessary for formation of a CBF-DNA complex: CBF-B interacts simultaneously with both the CBF-A and CBF-C subunits to form a heterotrimeric CBF molecule.
Molecular and cellular biology 1996;16(8):4003-13.
1996: Q Zhao; Richard R Behringer; Benoit de Crombrugghe
Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene.
Nature genetics 1996;13(3):275-83.
1996: Françoise Coustry; SANKAR MAITY; S Sinha; Benoit de Crombrugghe
The transcriptional activity of the CCAAT-binding factor CBF is mediated by two distinct activation domains, one in the CBF-B subunit and the other in the CBF-C subunit.
The Journal of biological chemistry 1996;271(24):14485-91.
1996: Veronique Lefebvre; K Mukhopadhyay; G Zhou; Silvio Garofalo; C Smith; Heidi Eberspaecher; J H Kimura; Benoit de Crombrugghe
A 47-bp sequence of the first intron of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte Expression.
Annals of the New York Academy of Sciences 1996;785():284-7.
1996: J A Rossert; S S Chen; Heidi Eberspaecher; C N Smith; Benoit de Crombrugghe
Identification of a minimal sequence of the mouse pro-alpha 1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1027-31.
1996: SANKAR MAITY; Benoit de Crombrugghe
Purification, characterization, and role of CCAAT-binding factor in transcription.
Methods in enzymology 1996;273():217-32.
1996: S Sinha; I S Kim; K Y Sohn; Benoit de Crombrugghe; SANKAR MAITY
Three classes of mutations in the A subunit of the CCAAT-binding factor CBF delineate functional domains involved in the three-step assembly of the CBF-DNA complex.
Molecular and cellular biology 1996;16(1):328-37.
1995: K Niederreither; R D'Souza; MP Metsäranta; Heidi Eberspaecher; P D Toman; Eero Vuorio; Benoit de Crombrugghe
Coordinate patterns of expression of type I and III collagens during mouse development.
Matrix biology : journal of the International Society for Matrix Biology 1995;14(9):705-13.
1995: G Zhou; Silvio Garofalo; K Mukhopadhyay; Veronique Lefebvre; C N Smith; Heidi Eberspaecher; Benoit de Crombrugghe
A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic mice.
Journal of cell science 1995;108 ( Pt 12)():3677-84.
1995: K Mukhopadhyay; Veronique Lefebvre; G Zhou; Silvio Garofalo; J H Kimura; Benoit de Crombrugghe
Use of a new rat chondrosarcoma cell line to delineate a 119-base pair chondrocyte-specific enhancer element and to define active promoter segments in the mouse pro-alpha 1(II) collagen gene.
The Journal of biological chemistry 1995;270(46):27711-9.
1995: MP Metsäranta; Silvio Garofalo; C Smith; K Niederreither; Benoit de Crombrugghe; Eero Vuorio
Developmental expression of a type II collagen/beta-galactosidase fusion gene in transgenic mice.
Developmental dynamics : an official publication of the American Association of Anatomists 1995;204(2):202-10.
1995: J Rossert; Heidi Eberspaecher; Benoit de Crombrugghe
Separate cis-acting DNA elements of the mouse pro-alpha 1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice.
The Journal of cell biology 1995;129(5):1421-32.
1995: S Sinha; SANKAR MAITY; J Lu; Benoit de Crombrugghe
Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1624-8.
1995: Benoit de Crombrugghe; P Katzenstein; K Mukhopadhyay; Veronique Lefebvre; Gang Zhou; Silvio Garofalo; MP Metsäranta; R Rosati; Eero Vuorio
Transgenic mice with deficiencies in cartilage collagens: possible models for gene therapy.
The Journal of rheumatology. Supplement 1995;43():140-2.
1995: Françoise Coustry; SANKAR MAITY; Benoit de Crombrugghe
Studies on transcription activation by the multimeric CCAAT-binding factor CBF.
The Journal of biological chemistry 1995;270(1):468-75.
1995: Veronique Lefebvre; Silvio Garofalo; Benoit de Crombrugghe
Type X collagen gene expression in mouse chondrocytes immortalized by a temperature-sensitive simian virus 40 large tumor antigen.
The Journal of cell biology 1995;128(1-2):239-45.
1994: G Q Zhao; Heidi Eberspaecher; Michael F Seldin; Benoit de Crombrugghe
The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development.
Mechanisms of development 1994;48(3):245-54.
1994: R Rosati; G S Horan; G J Pinero; Silvio Garofalo; Douglas R Keene; William A Horton; Eero Vuorio; Benoit de Crombrugghe; Richard R Behringer
Normal long bone growth and development in type X collagen-null mice.
Nature genetics 1994;8(2):129-35.
1994: P D Toman; Benoit de Crombrugghe
The mouse type-III procollagen-encoding gene: genomic cloning and complete DNA sequence.
Gene 1994;147(2):161-8.
1994: Veronique Lefebvre; Silvio Garofalo; G Zhou; MP Metsäranta; Eero Vuorio; Benoit de Crombrugghe
Characterization of primary cultures of chondrocytes from type II collagen/beta-galactosidase transgenic mice.
Matrix biology : journal of the International Society for Matrix Biology 1994;14(4):329-35.
1994: G Q Zhao; S Zhao; X Zhou; Heidi Eberspaecher; M Solursh; Benoit de Crombrugghe
rDlx, a novel distal-less-like homeoprotein is expressed in developing cartilages and discrete neuronal tissues.
Developmental biology 1994;164(1):37-51.
1994: K Y Sohn; SANKAR MAITY; Benoit de Crombrugghe
Studies on the structure of the mouse CBF-A gene and properties of a truncated CBF-A isoform generated from an alternatively spliced RNA.
Gene 1994;139(2):147-53.
1994: Maritta Perälä; K Elima; MP Metsäranta; R Rosati; Benoit de Crombrugghe; Eero Vuorio
The exon structure of the mouse alpha 2(IX) collagen gene shows unexpected divergence from the chick gene.
The Journal of biological chemistry 1994;269(7):5064-71.
1993: G Q Zhao; X Zhou; Heidi Eberspaecher; M Solursh; Benoit de Crombrugghe
Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8633-7.
1993: R N D'Souza; K Niederreither; Benoit de Crombrugghe
Osteoblast-specific expression of the alpha 2(I) collagen promoter in transgenic mice: correlation with the distribution of TGF-beta 1.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(9):1127-36.
1993: G Q Zhao; Q Zhao; X Zhou; M G Mattei; Benoit de Crombrugghe
TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation.
Molecular and cellular biology 1993;13(8):4505-12.
1993: M Rintala; MP Metsäranta; Silvio Garofalo; Benoit de Crombrugghe; Eero Vuorio; Olli Rönning
Abnormal craniofacial morphology and cartilage structure in transgenic mice harboring a Gly --> Cys mutation in the cartilage-specific type II collagen gene.
Journal of craniofacial genetics and developmental biology 1993;13(3):137-46.
1993: Silvio Garofalo; MP Metsäranta; J Ellard; C Smith; W Horton; Eero Vuorio; Benoit de Crombrugghe
Assembly of cartilage collagen fibrils is disrupted by overexpression of normal type II collagen in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):3825-9.
1993: K Elima; I Eerola; R Rosati; MP Metsäranta; Silvio Garofalo; Maritta Perälä; Benoit de Crombrugghe; Eero Vuorio
The mouse collagen X gene: complete nucleotide sequence, exon structure and expression pattern.
The Biochemical journal 1993;289 ( Pt 1)():247-53.
1992: K Niederreither; R N D'Souza; Benoit de Crombrugghe
Minimal DNA sequences that control the cell lineage-specific expression of the pro alpha 2(I) collagen promoter in transgenic mice.
The Journal of cell biology 1992;119(5):1361-70.
1992: H Goldberg; T Helaakoski; Lee Ann Garrett-Sinha; Gerard Karsenty; A Pellegrino; Guillermina Lozano; SANKAR MAITY; Benoit de Crombrugghe
Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells.
The Journal of biological chemistry 1992;267(27):19622-30.
1992: SANKAR MAITY; S Sinha; E C Ruteshouser; Benoit de Crombrugghe
Three different polypeptides are necessary for DNA binding of the mammalian heteromeric CCAAT binding factor.
The Journal of biological chemistry 1992;267(23):16574-80.
1992: E C Ruteshouser; Benoit de Crombrugghe
Purification of BBF, a DNA-binding protein recognizing a positive cis-acting element in the mouse alpha 1(III) collagen promoter.
The Journal of biological chemistry 1992;267(20):14398-404.
1992: MP Metsäranta; Silvio Garofalo; G Decker; M Rintala; Benoit de Crombrugghe; Eero Vuorio
Chondrodysplasia in transgenic mice harboring a 15-amino acid deletion in the triple helical domain of pro alpha 1(II) collagen chain.
The Journal of cell biology 1992;118(1):203-12.
1992: SANKAR MAITY; Benoit de Crombrugghe
Biochemical analysis of the B subunit of the heteromeric CCAAT-binding factor. A DNA-binding domain and a subunit interaction domain are specified by two separate segments.
The Journal of biological chemistry 1992;267(12):8286-92.
1992: Randy J Legerski; X Zhou; J Dresback; Heidi Eberspaecher; S McKinney; P Segarini; Benoit de Crombrugghe
Molecular cloning and characterization of a novel rat activin receptor.
Biochemical and biophysical research communications 1992;183(2):672-9.
1992: K Elima; MP Metsäranta; Jaana Kallio; Maritta Perälä; I Eerola; Silvio Garofalo; Benoit de Crombrugghe; Eero Vuorio
Specific hybridization probes for mouse alpha 2(IX) and alpha 1(X) collagen mRNAs.
Biochimica et biophysica acta 1992;1130(1):78-80.
1991: Gerard Karsenty; Roberto Ravazzolo; Benoit de Crombrugghe
Purification and functional characterization of a DNA-binding protein that interacts with a negative element in the mouse alpha 1(I) collagen promoter.
The Journal of biological chemistry 1991;266(36):24842-8.
1991: Benoit de Crombrugghe; T Vuorio; Gerard Karsenty; SANKAR MAITY; E C Rutheshouser; H Goldberg
Transcriptional control mechanisms for the expression of type I collagen genes.
Annals of the rheumatic diseases 1991;50 Suppl 4():872-6.
1991: MP Metsäranta; D Toman; Benoit de Crombrugghe; Eero Vuorio
Mouse type II collagen gene. Complete nucleotide sequence, exon structure, and alternative splicing.
The Journal of biological chemistry 1991;266(25):16862-9.
1991: MP Metsäranta; D Toman; Benoit de Crombrugghe; Eero Vuorio
Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs.
Biochimica et biophysica acta 1991;1089(2):241-3.
1991: G Karsenty; Benoit de Crombrugghe
Conservation of binding sites for regulatory factors in the coordinately expressed alpha 1 (I) and alpha 2 (I) collagen promoters.
Biochemical and biophysical research communications 1991;177(1):538-44.
1991: Roberto Ravazzolo; Gerard Karsenty; Benoit de Crombrugghe
A fibroblast-specific factor binds to an upstream negative control element in the promoter of the mouse alpha 1(I) collagen gene.
The Journal of biological chemistry 1991;266(12):7382-7.
1990: T Vuorio; SANKAR MAITY; Benoit de Crombrugghe
Purification and molecular cloning of the "A" chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor.
The Journal of biological chemistry 1990;265(36):22480-6.
1990: SANKAR MAITY; T Vuorio; Benoit de Crombrugghe
The B subunit of a rat heteromeric CCAAT-binding transcription factor shows a striking sequence identity with the yeast Hap2 transcription factor.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(14):5378-82.
1990: Gerard Karsenty; Benoit de Crombrugghe
Two different negative and one positive regulatory factors interact with a short promoter segment of the alpha 1 (I) collagen gene.
The Journal of biological chemistry 1990;265(17):9934-42.
1990: Benoit de Crombrugghe; T Vuorio; Gerard Karsenty
Control of type I collagen genes in scleroderma and normal fibroblasts.
Rheumatic diseases clinics of North America 1990;16(1):109-23.
1990: Benoit de Crombrugghe; Gerard Karsenty; SANKAR MAITY; T Vuorio; P Rossi; E C Ruteshouser; S H McKinney; Guillermina Lozano
Transcriptional mechanisms controlling types I and III collagen genes.
Annals of the New York Academy of Sciences 1990;580():88-96.
1989: E C Ruteshouser; Benoit de Crombrugghe
Characterization of two distinct positive cis-acting elements in the mouse alpha 1 (III) collagen promoter.
The Journal of biological chemistry 1989;264(23):13740-4.
1988: Gerard Karsenty; P Golumbek; Benoit de Crombrugghe
Point mutations and small substitution mutations in three different upstream elements inhibit the activity of the mouse alpha 2(I) collagen promoter.
The Journal of biological chemistry 1988;263(27):13909-15.