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Antonio De Flora

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Santina Bruzzone; Raul Cassia; Antonio De Flora; Chiara Fresia; Alessia Grozio; Lucrezia Guida; Lorenzo Lamattina; Mirko Magnone; Elena Mannino; Annalisa Salis; Laura Sturla; Vanesa Tossi; Tiziana Vigliarolo; Giovanna Basile; Elena Zocchi
Autocrine abscisic acid mediates the UV-B-induced inflammatory response in human granulocytes and keratinocytes.
Santina Bruzzone; Giuseppe Colombo; Renzo Cordera; Gianluca Damonte; Antonio De Flora; Daniela Fenoglio; Francesca Fiory; Alessia Grozio; Lucrezia Guida; Davide Maggi; Mirko Magnone; Elena Mannino; Claudia Miele; Giovanni Murialdo; Alessio Nencioni; Vittorio Ruvolo; Annalisa Salis; Sonia Scarfì; Laura Sturla; Pietro Ameri; Gabriella Andraghetti; Giovanna Basile; Francesco Beguinot; Mariano Bormioli; Lucia Briatore; Elena Zocchi
The plant hormone abscisic acid increases in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes and myoblasts.
Mirko Magnone; Annalisa Salis; Sonia Scarfì; Laura Sturla; Cesare Usai; Santina Bruzzone; Gianluca Damonte; Antonio De Flora; Lucrezia Guida; Emanuela Jacchetti; Elena Zocchi
Autocrine abscisic acid plays a key role in quartz-induced macrophage activation.

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All Publications

2012: Santina Bruzzone; Raul Cassia; Antonio De Flora; Chiara Fresia; Alessia Grozio; Lucrezia Guida; Lorenzo Lamattina; Mirko Magnone; Elena Mannino; Annalisa Salis; Laura Sturla; Vanesa Tossi; Tiziana Vigliarolo; Giovanna Basile; Elena Zocchi
Autocrine abscisic acid mediates the UV-B-induced inflammatory response in human granulocytes and keratinocytes.
Journal of cellular physiology 2012;227(6):2502-10.
2012: Santina Bruzzone; Giuseppe Colombo; Renzo Cordera; Gianluca Damonte; Antonio De Flora; Daniela Fenoglio; Francesca Fiory; Alessia Grozio; Lucrezia Guida; Davide Maggi; Mirko Magnone; Elena Mannino; Claudia Miele; Giovanni Murialdo; Alessio Nencioni; Vittorio Ruvolo; Annalisa Salis; Sonia Scarfì; Laura Sturla; Pietro Ameri; Gabriella Andraghetti; Giovanna Basile; Francesco Beguinot; Mariano Bormioli; Lucia Briatore; Elena Zocchi
The plant hormone abscisic acid increases in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes and myoblasts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(3):1251-60.
2012: Mirko Magnone; Annalisa Salis; Sonia Scarfì; Laura Sturla; Cesare Usai; Santina Bruzzone; Gianluca Damonte; Antonio De Flora; Lucrezia Guida; Emanuela Jacchetti; Elena Zocchi
Autocrine abscisic acid plays a key role in quartz-induced macrophage activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(3):1261-71.
2011: Alessia Grozio; Lucrezia Guida; Mirko Magnone; Enrico Millo; Annalisa Salis; Laura Sturla; Tiziana Vigliarolo; L Bagnasco; Marta Bellotti; Santina Bruzzone; Gianluca Damonte; Antonio De Flora; Chiara Fresia; Andrea Galatini; Elena Zocchi
Functional characterization of a synthetic abscisic acid analog with anti-inflammatory activity on human granulocytes and monocytes.
Biochemical and biophysical research communications 2011;415(4):696-701.
2011: Laura Sturla; Tiziana Vigliarolo; L Bagnasco; Santina Bruzzone; Antonio De Flora; Chiara Fresia; Alessia Grozio; Lucrezia Guida; Elena Mannino; Enrico Millo; Elena Zocchi
Binding of abscisic acid to human LANCL2.
Biochemical and biophysical research communications 2011;415(2):390-5.
2011: Floriana Fruscione; Lucrezia Guida; Cristina Ilengo; Emanuela Jacchetti; Rodolfo Quarto; Annalisa Salis; Silvia Scaglione; Sonia Scarfì; Antonio Uccelli; Cesare Usai; Elena Zocchi; Federica Benvenuto; Santina Bruzzone; Chiara Ferraris; Antonio De Flora
Regulation of human mesenchymal stem cell functions by an autocrine loop involving NAD+ release and P2Y11-mediated signaling.
Stem cells and development 2011;20(7):1183-98.
2010: Santina Bruzzone; Giovanna Basile; Madhu Parakkottil Chothi; Lucilla Nobbio; Cesare Usai; Emanuela Jacchetti; Angelo Schenone; Andreas H Guse; Francesco Di Virgilio; Antonio De Flora; Elena Zocchi
Diadenosine homodinucleotide products of ADP-ribosyl cyclases behave as modulators of the purinergic receptor P2X7.
The Journal of biological chemistry 2010;285(27):21165-74.
2009: Laura Sturla; Chiara Fresia; Lucrezia Guida; Santina Bruzzone; Sonia Scarfì; Cesare Usai; Floriana Fruscione; Mirko Magnone; Enrico Millo; Giovanna Basile; Alessia Grozio; Emanuela Jacchetti; Marcello Allegretti; Antonio De Flora; Elena Zocchi
LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells.
The Journal of biological chemistry 2009;284(41):28045-57.
2009: Sonia Scarfì; Chiara Fresia; Chiara Ferraris; Santina Bruzzone; Floriana Fruscione; Cesare Usai; Federica Benvenuto; Mirko Magnone; Marina Podestà; Laura Sturla; Lucrezia Guida; Ennio Albanesi; Gianluca Damonte; Annalisa Salis; Antonio De Flora; Elena Zocchi
The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose.
Stem cells (Dayton, Ohio) 2009;27(10):2469-77.
2009: Lucilla Nobbio; Laura Sturla; Fulvia Fiorese; Cesare Usai; Giovanna Basile; Iliana Moreschi; Federica Benvenuto; Elena Zocchi; Antonio De Flora; Angelo Schenone; Santina Bruzzone
P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy.
The Journal of biological chemistry 2009;284(34):23146-58.
2009: Mirko Magnone; Santina Bruzzone; Lucrezia Guida; Gianluca Damonte; Enrico Millo; Sonia Scarfì; Cesare Usai; Laura Sturla; Domenico Palombo; Antonio De Flora; Elena Zocchi
Abscisic acid released by human monocytes activates monocytes and vascular smooth muscle cell responses involved in atherogenesis.
The Journal of biological chemistry 2009;284(26):17808-18.
2009: Nicoletta Bodrato; Luisa Franco; Chiara Fresia; Lucrezia Guida; Cesare Usai; Annalisa Salis; Iliana Moreschi; Chiara Ferraris; Claudia Verderio; Giovanna Basile; Santina Bruzzone; Sonia Scarfì; Antonio De Flora; Elena Zocchi
Abscisic acid activates the murine microglial cell line N9 through the second messenger cyclic ADP-ribose.
The Journal of biological chemistry 2009;284(22):14777-87.
2008: Santina Bruzzone; Nicoletta Bodrato; Cesare Usai; Lucrezia Guida; Iliana Moreschi; Rita Nano; Barbara Antonioli; Floriana Fruscione; Mirko Magnone; Sonia Scarfì; Antonio De Flora; Elena Zocchi
Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger.
The Journal of biological chemistry 2008;283(47):32188-97.
2008: Sonia Scarfì; Chiara Ferraris; Floriana Fruscione; Chiara Fresia; Lucrezia Guida; Santina Bruzzone; Cesare Usai; Alessia Parodi; Enrico Millo; Annalisa Salis; Giorgio Burastero; Antonio De Flora; Elena Zocchi
Cyclic ADP-ribose-mediated expansion and stimulation of human mesenchymal stem cells by the plant hormone abscisic acid.
Stem cells (Dayton, Ohio) 2008;26(11):2855-64.
2008: Iliana Moreschi; Santina Bruzzone; Nicoletta Bodrato; Cesare Usai; Lucrezia Guida; Robert A Nicholas; Matthias U Kassack; Elena Zocchi; Antonio De Flora
NAADP+ is an agonist of the human P2Y11 purinergic receptor.
Cell calcium 2008;43(4):344-55.
2008: Floriana Fruscione; Laura Sturla; Garry Duncan; James L Van Etten; Paola Valbuzzi; Antonio De Flora; Eleonora Di Zanni; Michela Tonetti
Differential role of NADP+ and NADPH in the activity and structure of GDP-D-mannose 4,6-dehydratase from two chlorella viruses.
The Journal of biological chemistry 2008;283(1):184-93.
2007: Santina Bruzzone; Iliana Moreschi; Cesare Usai; Lucrezia Guida; Gianluca Damonte; Annalisa Salis; Sonia Scarfì; Enrico Millo; Antonio De Flora; Elena Zocchi
Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5759-64.
2007: Santina Bruzzone; Giuliano Dodoni; Nina Kaludercic; Giovanna Basile; Enrico Millo; Antonio De Flora; Fabio Di Lisa; Elena Zocchi
Mitochondrial dysfunction induced by a cytotoxic adenine dinucleotide produced by ADP-ribosyl cyclases from cADPR.
The Journal of biological chemistry 2007;282(7):5045-52.
2006: Richard Billington; Santina Bruzzone; Antonio De Flora; Armando Genazzani; Friedrich Koch-Nolte; Mathias Ziegler; Elena Zocchi
Emerging functions of extracellular pyridine nucleotides.
Molecular medicine (Cambridge, Mass.) 2006;12(11-12):324-7.
2006: Iliana Moreschi; Santina Bruzzone; Robert A Nicholas; Floriana Fruscione; Laura Sturla; Federica Benvenuto; Cesare Usai; Sabine Meis; Matthias U Kassack; Elena Zocchi; Antonio De Flora
Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes.
The Journal of biological chemistry 2006;281(42):31419-29.
2006: Luisa Franco; Nicoletta Bodrato; Iliana Moreschi; Cesare Usai; Santina Bruzzone; Sonia Scarf ì; Elena Zocchi; Antonio De Flora
Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated activation of murine N9 microglial cell line.
Journal of neurochemistry 2006;99(1):165-76.
2006: Silvio De Flora; Sonia Scarfì; Alberto Izzotti; Francesco D'Agostini; Chia-Cheng Chang; Marcello Bagnasco; Antonio De Flora; James E Trosko
Induction by 7,12-dimethylbenz(a)anthracene of molecular and biochemical alterations in transformed human mammary epithelial stem cells, and protection by N-acetylcysteine.
International journal of oncology 2006;29(3):521-9.
2006: Iliana Moreschi; Santina Bruzzone; Luca Melone; Antonio De Flora; Elena Zocchi
NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases.
Biochemical and biophysical research communications 2006;345(2):573-80.
2006: Santina Bruzzone; Iliana Moreschi; Lucrezia Guida; Cesare Usai; Elena Zocchi; Antonio De Flora
Extracellular NAD+ regulates intracellular calcium levels and induces activation of human granulocytes.
The Biochemical journal 2006;393(Pt 3):697-704.
2005: Giovanna Basile; Orazio Taglialatela-Scafati; Gianluca Damonte; Andrea Armirotti; Santina Bruzzone; Lucrezia Guida; Luisa Franco; Cesare Usai; Ernesto Fattorusso; Antonio De Flora; Elena Zocchi
ADP-ribosyl cyclases generate two unusual adenine homodinucleotides with cytotoxic activity on mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(41):14509-14.
2005: Andrea Bacigalupo; Marisa Valle; Marina Podestà; Anna Pitto; Elena Zocchi; Antonio De Flora; Sarah Pozzi; Silvia Luchetti; Francesco Frassoni; Maria Teresa Van Lint; Giovanna Piaggio
T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia.
Experimental hematology 2005;33(7):819-27.
2005: Marina Podestà; Federica Benvenuto; Anna Pitto; Osvaldo Figari; Andrea Bacigalupo; Santina Bruzzone; Lucrezia Guida; Luisa Franco; Laura Paleari; Nicoletta Bodrato; Cesare Usai; Antonio De Flora; Elena Zocchi
Concentrative uptake of cyclic ADP-ribose generated by BST-1+ stroma stimulates proliferation of human hematopoietic progenitors.
The Journal of biological chemistry 2005;280(7):5343-9.
2004: Antonio De Flora; Elena Zocchi; Lucrezia Guida; Luisa Franco; Santina Bruzzone
Autocrine and paracrine calcium signaling by the CD38/NAD+/cyclic ADP-ribose system.
Annals of the New York Academy of Sciences 2004;1028():176-91.
2004: Lucrezia Guida; Luisa Franco; Santina Bruzzone; Laura Sturla; Elena Zocchi; Giovanna Basile; Cesare Usai; Antonio De Flora
Concentrative influx of functionally active cyclic ADP-ribose in dimethyl sulfoxide-differentiated HL-60 cells.
The Journal of biological chemistry 2004;279(21):22066-75.
2004: Santina Bruzzone; Claudia Verderio; Ursula Schenk; Ernesto Fedele; Elena Zocchi; Michela Matteoli; Antonio De Flora
Glutamate-mediated overexpression of CD38 in astrocytes cultured with neurones.
Journal of neurochemistry 2004;89(1):264-72.
2003: Santina Bruzzone; Svenja Kunerth; Elena Zocchi; Antonio De Flora; Andreas H Guse
Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors.
The Journal of cell biology 2003;163(4):837-45.
2003: Santina Bruzzone; Antonio De Flora; Cesare Usai; Richard Graeff; Hon Cheung Lee
Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated proliferation of human peripheral blood mononuclear cells.
The Biochemical journal 2003;375(Pt 2):395-403.
2003: Michela Tonetti; Davide Zanardi; James R Gurnon; Floriana Fruscione; Andrea Armirotti; Gianluca Damonte; Laura Sturla; Antonio De Flora; James L Van Etten
Paramecium bursaria Chlorella virus 1 encodes two enzymes involved in the biosynthesis of GDP-L-fucose and GDP-D-rhamnose.
The Journal of biological chemistry 2003;278(24):21559-65.
2003: Marina Podestà; Anna Pitto; Osvaldo Figari; Andrea Bacigalupo; Santina Bruzzone; Lucrezia Guida; Luisa Franco; Antonio De Flora; Elena Zocchi
Cyclic ADP-ribose generation by CD38 improves human hemopoietic stem cell engraftment into NOD/SCID mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(2):310-2.
2002: Lucrezia Guida; Santina Bruzzone; Laura Sturla; Luisa Franco; Elena Zocchi; Antonio De Flora
Equilibrative and concentrative nucleoside transporters mediate influx of extracellular cyclic ADP-ribose into 3T3 murine fibroblasts.
The Journal of biological chemistry 2002;277(49):47097-105.
2001: Santina Bruzzone; Luisa Franco; Lucrezia Guida; Elena Zocchi; Paola Contini; A Bisso; Cesare Usai; Antonio De Flora
A self-restricted CD38-connexin 43 cross-talk affects NAD+ and cyclic ADP-ribose metabolism and regulates intracellular calcium in 3T3 fibroblasts.
The Journal of biological chemistry 2001;276(51):48300-8.
2001: Claudia Verderio; Santina Bruzzone; Elena Zocchi; Ernesto Fedele; Ursula Schenk; Antonio De Flora; Michela Matteoli
Evidence of a role for cyclic ADP-ribose in calcium signalling and neurotransmitter release in cultured astrocytes.
Journal of neurochemistry 2001;78(3):646-57.
2001: Elena Zocchi; Marina Podestà; Anna Pitto; Cesare Usai; Santina Bruzzone; Luisa Franco; Lucrezia Guida; A Bacigalupo; Antonio De Flora
Paracrinally stimulated expansion of early human hemopoietic progenitors by stroma-generated cyclic ADP-ribose.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(9):1610-2.
2001: L Franco; Elena Zocchi; Cesare Usai; Lucrezia Guida; Santina Bruzzone; A Costa; Antonio De Flora
Paracrine roles of NAD+ and cyclic ADP-ribose in increasing intracellular calcium and enhancing cell proliferation of 3T3 fibroblasts.
The Journal of biological chemistry 2001;276(24):21642-8.
2001: Laura Sturla; Luigi Puglielli; Michela Tonetti; Patricia M Berninsone; Carlos B Hirschberg; Antonio De Flora; Amos Etzioni
Impairment of the Golgi GDP-L-fucose transport and unresponsiveness to fucose replacement therapy in LAD II patients.
Pediatric research 2001;49(4):537-42.
2001: L Franco; Santina Bruzzone; Pingfang Song; Lucrezia Guida; Elena Zocchi; T F Walseth; Emanuele Crimi; Cesare Usai; Antonio De Flora; Vito Brusasco
Extracellular cyclic ADP-ribose potentiates ACh-induced contraction in bovine tracheal smooth muscle.
American journal of physiology. Lung cellular and molecular physiology 2001;280(1):L98-L106.
2000: Camillo Rosano; A Bisso; G Izzo; Michela Tonetti; Laura Sturla; Antonio De Flora; Martino Bolognesi
Probing the catalytic mechanism of GDP-4-keto-6-deoxy-d-mannose Epimerase/Reductase by kinetic and crystallographic characterization of site-specific mutants.
Journal of molecular biology 2000;303(1):77-91.
2000: Marina Podestà; Elena Zocchi; Anna Pitto; Cesare Usai; Luisa Franco; Santina Bruzzone; Lucrezia Guida; A Bacigalupo; D T Scadden; T F Walseth; Antonio De Flora; Antonio Daga
Extracellular cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(5):680-90.
2000: Antonio De Flora; Luisa Franco; Lucrezia Guida; Santina Bruzzone; Cesare Usai; Elena Zocchi
Topology of CD38.
Chemical immunology 2000;75():79-98.
1999: A Bisso; Laura Sturla; Davide Zanardi; Antonio De Flora; Michela Tonetti
Structural and enzymatic characterization of human recombinant GDP-D-mannose-4,6-dehydratase.
FEBS letters 1999;456(3):370-4.
1999: Alessandra Fraternale; A Tonelli; Anna Casabianca; G Vallanti; Laura Chiarantini; Giuditta F Schiavano; Umberto Benatti; Antonio De Flora; Mauro Magnani
Role of macrophage protection in the development of murine AIDS.
Journal of acquired immune deficiency syndromes (1999) 1999;21(2):81-9.
1999: Luigia Rossi; Giorgio Brandi; Giuditta F Schiavano; Sonia Scarfi; Enrico Millo; Gianluca Damonte; Umberto Benatti; Antonio De Flora; Mauro Magnani
Heterodimer-loaded erythrocytes as bioreactors for slow delivery of the antiviral drug azidothymidine and the antimycobacterial drug ethambutol.
AIDS research and human retroviruses 1999;15(4):345-53.
1999: Elena Zocchi; Cesare Usai; Lucrezia Guida; Luisa Franco; Santina Bruzzone; Mario Passalacqua; Antonio De Flora
Ligand-induced internalization of CD38 results in intracellular Ca2+ mobilization: role of NAD+ transport across cell membranes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(2):273-83.
1998: Michela Tonetti; Laura Sturla; A Bisso; Davide Zanardi; Umberto Benatti; Antonio De Flora
The metabolism of 6-deoxyhexoses in bacterial and animal cells.
Biochimie 1998;80(11):923-31.
1998: Luisa Franco; Lucrezia Guida; Santina Bruzzone; Elena Zocchi; Cesare Usai; Antonio De Flora
The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(14):1507-20.
1998: Santina Bruzzone; Lucrezia Guida; Luisa Franco; Elena Zocchi; G Corte; Antonio De Flora
Dimeric and tetrameric forms of catalytically active transmembrane CD38 in transfected HeLa cells.
FEBS letters 1998;433(3):275-8.
1998: Michela Tonetti; M Rizzi; P Vigevani; Laura Sturla; A Bisso; Antonio De Flora; Martino Bolognesi
Preliminary crystallographic investigations of recombinant GDP-4-keto-6-deoxy-D-mannose epimerase/reductase from E. coli.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 4):684-6.
1998: Laura Sturla; Amos Etzioni; A Bisso; Davide Zanardi; G De Flora; L Silengo; Antonio De Flora; Michela Tonetti
Defective intracellular activity of GDP-D-mannose-4,6-dehydratase in leukocyte adhesion deficiency type II syndrome.
FEBS letters 1998;429(3):274-8.
1998: Elena Zocchi; Antonio Daga; Cesare Usai; Luisa Franco; Lucrezia Guida; Santina Bruzzone; A Costa; Carla Marchetti; Antonio De Flora
Expression of CD38 increases intracellular calcium concentration and reduces doubling time in HeLa and 3T3 cells.
The Journal of biological chemistry 1998;273(14):8017-24.
1998: Luigia Rossi; Giorgio Brandi; Giuditta F Schiavano; Emanuela Balestra; Enrico Millo; Sonia Scarfi; Gianluca Damonte; A Gasparini; Mauro Magnani; Carlo Federico Perno; Umberto Benatti; Antonio De Flora
Macrophage protection against human immunodeficiency virus or herpes simplex virus by red blood cell-mediated delivery of a heterodinucleotide of azidothymidine and acyclovir.
AIDS research and human retroviruses 1998;14(5):435-44.
1998: Mauro Magnani; Anna Casabianca; Alessandra Fraternale; Giorgio Brandi; Laura Chiarantini; Umberto Benatti; Sonia Scarfì; Enrico Millo; Antonio De Flora
Inhibition of murine AIDS by a new azidothymidine homodinucleotide.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998;17(3):189-95.
1998: Antonio De Flora; Luisa Franco; Lucrezia Guida; Santina Bruzzone; Elena Zocchi
Ectocellular CD38-catalyzed synthesis and intracellular Ca(2+)-mobilizing activity of cyclic ADP-ribose.
Cell biochemistry and biophysics 1998;28(1):45-62.
1997: Antonio De Flora; Lucrezia Guida; Luisa Franco; Elena Zocchi
The CD38/cyclic ADP-ribose system: a topological paradox.
The international journal of biochemistry & cell biology 1997;29(10):1149-66.
1997: Laura Sturla; A Bisso; Davide Zanardi; Umberto Benatti; Antonio De Flora; Michela Tonetti
Expression, purification and characterization of GDP-D-mannose 4,6-dehydratase from Escherichia coli.
FEBS letters 1997;412(1):126-30.
1997: Mauro Magnani; L Rossi; Alessandra Fraternale; Anna Casabianca; Giorgio Brandi; Umberto Benatti; Antonio De Flora
Targeting antiviral nucleotide analogues to macrophages.
Journal of leukocyte biology 1997;62(1):133-7.
1997: Antonio De Flora; Lucrezia Guida; Luisa Franco; Elena Zocchi; Santina Bruzzone; Umberto Benatti; Gianluca Damonte; Hon Cheung Lee
CD38 and ADP-ribosyl cyclase catalyze the synthesis of a dimeric ADP-ribose that potentiates the calcium-mobilizing activity of cyclic ADP-ribose.
The Journal of biological chemistry 1997;272(20):12945-51.
1997: Michela Tonetti; Enrico Millo; Laura Sturla; A Bisso; Antonio De Flora
Effects of the murine L929 and L1210 cell lines on nitric oxide and TNF-alpha production by RAW 264.7 murine macrophages.
Biochemical and biophysical research communications 1997;230(3):636-40.
1996: Antonio De Flora; Lucrezia Guida; Luisa Franco; Elena Zocchi; Mario Pestarino; Cesare Usai; Carla Marchetti; E Fedele; G Fontana; M Raiteri
Ectocellular in vitro and in vivo metabolism of cADP-ribose in cerebellum.
The Biochemical journal 1996;320 ( Pt 2)():665-71.
1996: Elena Zocchi; Luisa Franco; Lucrezia Guida; D Piccini; Carlo Tacchetti; Antonio De Flora
NAD+-dependent internalization of the transmembrane glycoprotein CD38 in human Namalwa B cells.
FEBS letters 1996;396(2-3):327-32.
1996: Michela Tonetti; Laura Sturla; A Bisso; Umberto Benatti; Antonio De Flora
Synthesis of GDP-L-fucose by the human FX protein.
The Journal of biological chemistry 1996;271(44):27274-9.
1996: Mauro Magnani; Anna Casabianca; Alessandra Fraternale; Giorgio Brandi; S Gessani; R Williams; Marco Giovine; Gianluca Damonte; Antonio De Flora; Umberto Benatti
Synthesis and targeted delivery of an azidothymidine homodinucleotide conferring protection to macrophages against retroviral infection.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4403-8.
1996: Umberto Benatti; Marco Giovine; Gianluca Damonte; A Gasparini; Sonia Scarfi; Antonio De Flora; Alessandra Fraternale; L Rossi; Mauro Magnani
Azidothymidine homodinucleotide-loaded erythrocytes and bioreactors for slow delivery of the antiretroviral drug azidothymidine.
Biochemical and biophysical research communications 1996;220(1):20-5.
1995: Michela Tonetti; Laura Sturla; Marco Giovine; Umberto Benatti; Antonio De Flora
Extracellular ATP enhances mRNA levels of nitric oxide synthase and TNF-alpha in lipopolysaccharide-treated RAW 264.7 murine macrophages.
Biochemical and biophysical research communications 1995;214(1):125-30.
1995: Lucrezia Guida; Luisa Franco; Elena Zocchi; Antonio De Flora
Structural role of disulfide bridges in the cyclic ADP-ribose related bifunctional ectoenzyme CD38.
FEBS letters 1995;368(3):481-4.
1995: Elena Zocchi; Luisa Franco; Lucrezia Guida; L Calder; Antonio De Flora
Self-aggregation of purified and membrane-bound erythrocyte CD38 induces extensive decrease of its ADP-ribosyl cyclase activity.
FEBS letters 1995;359(1):35-40.
1995: Laura Camardella; Vito Carratore; M A Ciardiello; Gianluca Damonte; Umberto Benatti; Antonio De Flora
Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum- transplantation antigen P35B.
Blood 1995;85(1):264-7.
1994: A Gasparini; Marco Giovine; Gianluca Damonte; Michela Tonetti; T Grandi; Mauro Mazzei; Alessandro Balbi; L Silvestro; Umberto Benatti; Antonio De Flora
A novel dimeric fluoropyrimidine molecule behaves as a remote precursor of 5-fluoro-2'-deoxyuridine in human erythrocytes.
Biochemical pharmacology 1994;48(6):1121-8.
1994: Michela Tonetti; Laura Sturla; T Bistolfi; Umberto Benatti; Antonio De Flora
Extracellular ATP potentiates nitric oxide synthase expression induced by lipopolysaccharide in RAW 264.7 murine macrophages.
Biochemical and biophysical research communications 1994;203(1):430-5.
1994: Luisa Franco; Elena Zocchi; L Calder; Lucrezia Guida; Umberto Benatti; Antonio De Flora
Self-aggregation of the transmembrane glycoprotein CD38 purified from human erythrocytes.
Biochemical and biophysical research communications 1994;202(3):1710-5.
1994: Michela Tonetti; Laura Sturla; T Bistolfi; Umberto Benatti; Antonio De Flora
Synergistic cytotoxicity of carboplatin and divicine on murine erythroleukemic cells.
Biochemical and biophysical research communications 1994;200(1):654-60.
1993: Elena Zocchi; Luisa Franco; Lucrezia Guida; Umberto Benatti; Antonio Bargellesi; F Malavasi; H C Lee; Antonio De Flora
A single protein immunologically identified as CD38 displays NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities at the outer surface of human erythrocytes.
Biochemical and biophysical research communications 1993;196(3):1459-65.
1993: Michela Tonetti; Marco Giovine; A Gasparini; Umberto Benatti; Antonio De Flora
Enhanced formation of reactive species from cis-diammine-(1,1-cyclobutanedicarboxylato)-platinum(II) (carboplatin) in the presence of oxygen free radicals.
Biochemical pharmacology 1993;46(8):1377-83.
1993: Elena Zocchi; Lucrezia Guida; Luisa Franco; L Silvestro; M Guerrini; Umberto Benatti; Antonio De Flora
Free ADP-ribose in human erythrocytes: pathways of intra-erythrocytic conversion and non-enzymic binding to membrane proteins.
The Biochemical journal 1993;295 ( Pt 1)():121-30.
1993: Luisa Franco; Lucrezia Guida; Elena Zocchi; L Silvestro; Umberto Benatti; Antonio De Flora
Adenosine diphosphate ribulose in human erythrocytes: a new metabolite with membrane binding properties.
Biochemical and biophysical research communications 1993;190(3):1143-8.
1993: Antonio De Flora; Michela Tonetti; Elena Zocchi; Lucrezia Guida; C Polvani; A Gasparini; Umberto Benatti
Engineered erythrocytes as carriers and bioreactors.
The Year in immunology 1993;7():168-74.
1992: Gianluca Damonte; Lucrezia Guida; A Sdraffa; Umberto Benatti; Edon Melloni; G Forteleoni; T Meloni; E Carafoli; Antonio De Flora
Mechanisms of perturbation of erythrocyte calcium homeostasis in favism.
Cell calcium 1992;13(10):649-58.
1992: Lucrezia Guida; Elena Zocchi; Luisa Franco; Umberto Benatti; Antonio De Flora
Presence and turnover of adenosine diphosphate ribose in human erythrocytes.
Biochemical and biophysical research communications 1992;188(1):402-8.
1992: Michela Tonetti; A Gasparini; Marco Giovine; D Bini; A Mazzucotelli; F De Paz; Umberto Benatti; Antonio De Flora
Interaction of carboplatin with carrier human erythrocytes.
Biotechnology and applied biochemistry 1992;15(3):267-77.
1992: Michela Tonetti; A Gasparini; Marco Giovine; Umberto Benatti; Antonio De Flora
Enhanced intracellular activation of carboplatin in hemoglobin-synthesizing versus undifferentiated erythroleukemic cells.
Biochemical and biophysical research communications 1992;182(2):760-6.
1992: Michela Tonetti; A Gasparini; Marco Giovine; Umberto Benatti; Antonio De Flora
Interactions of carboplatin with human erythrocytes and murine erythroleukemic cells.
Advances in experimental medicine and biology 1992;326():223-32.
1991: Michela Tonetti; A B Astroff; William C Satterfield; Antonio De Flora; Umberto Benatti; JR Deloach
Pharmacokinetic properties of doxorubicin encapsulated in glutaraldehyde-treated canine erythrocytes.
American journal of veterinary research 1991;52(10):1630-5.
1991: Antonio De Flora; Gianluca Damonte; A Sdraffa; Luisa Franco; Umberto Benatti
Heterogeneity of guanine nucleotide binding proteins in human red blood cell membranes.
Advances in experimental medicine and biology 1991;307():161-71.
1990: Michela Tonetti; B Astroff; William C Satterfield; Antonio De Flora; Umberto Benatti; JR Deloach
Construction and characterization of adriamycin-loaded canine red blood cells as a potential slow delivery system.
Biotechnology and applied biochemistry 1990;12(6):621-9.
1990: Gianluca Damonte; A Sdraffa; Elena Zocchi; Lucrezia Guida; C Polvani; Michela Tonetti; Umberto Benatti; P Boquet; Antonio De Flora
Multiple small molecular weight guanine nucleotide-binding proteins in human erythrocyte membranes.
Biochemical and biophysical research communications 1990;166(3):1398-405.
1989: Umberto Benatti; Elena Zocchi; Michela Tonetti; Lucrezia Guida; C Polvani; Antonio De Flora
Enhanced antitumor activity of adriamycin by encapsulation in mouse erythrocytes targeted to liver and lungs.
Pharmacological research : the official journal of the Italian Pharmacological Society 1989;21 Suppl 2():27-33.
1989: Elena Zocchi; Michela Tonetti; C Polvani; Lucrezia Guida; Umberto Benatti; Antonio De Flora
Encapsulation of doxorubicin in liver-targeted erythrocytes increases the therapeutic index of the drug in a murine metastatic model.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(6):2040-4.
1989: Gianluca Damonte; A Morelli; M Piu; P Longone; Antonio De Flora
"In situ" characterization of guanine nucleotide-binding properties of erythrocyte membranes.
Biochemical and biophysical research communications 1989;159(1):41-7.
1988: Elena Zocchi; Michela Tonetti; C Polvani; Lucrezia Guida; Umberto Benatti; Antonio De Flora
In vivo liver and lung targeting of adriamycin encapsulated in glutaraldehyde-treated murine erythrocytes.
Biotechnology and applied biochemistry 1988;10(6):555-62.
1988: Antonio De Flora; Elena Zocchi; Lucrezia Guida; C Polvani; Umberto Benatti
Conversion of encapsulated 5-fluoro-2'-deoxyuridine 5'-monophosphate to the antineoplastic drug 5-fluoro-2'-deoxyuridine in human erythrocytes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(9):3145-9.
1987: Elena Zocchi; Lucrezia Guida; Umberto Benatti; M Canepa; L Borgiani; T Zanin; Antonio De Flora
Hepatic or splenic targeting of carrier erythrocytes: a murine model.
Biotechnology and applied biochemistry 1987;9(5):423-34.
1986: Antonio De Flora; Umberto Benatti; Lucrezia Guida
The role of plasma in oxidative haemolysis.
Free radical research communications 1986;1(3):201-24.
1980: G Damiani; M Frascio; Umberto Benatti; A Morelli; Elena Zocchi; Marina Fabbi; Antonio Bargellesi; S Pontremoli; Antonio De Flora
Monoclonal antibodies to human erythrocyte glucose 6-phosphate dehydrogenase.
FEBS letters 1980;119(1):169-73.