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Jan-Willem de Gier

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Susan Schlegel; A Jimmy Ytterberg; Roman A Zubarev; Joen Luirink; Edurne Rujas; Jan-Willem de Gier
Optimizing heterologous protein production in the periplasm of E. coli by regulating gene expression levels.
Susan Schlegel; Dirk-Jan Slotboom; Marc Strous; David Drew; Anna Hjelm; Mirjam Klepsch; Chiara Lee; John Löfblom; Jan-Willem de Gier
Optimizing membrane protein overexpression in the Escherichia coli strain Lemo21(DE3).
Joen Luirink; Samuel Wagner; Zhong Yu; Jan-Willem de Gier
Biogenesis of inner membrane proteins in Escherichia coli.

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2013: Susan Schlegel; A Jimmy Ytterberg; Roman A Zubarev; Joen Luirink; Edurne Rujas; Jan-Willem de Gier
Optimizing heterologous protein production in the periplasm of E. coli by regulating gene expression levels.
Microbial cell factories 2013;12():24.
2012: Susan Schlegel; Dirk-Jan Slotboom; Marc Strous; David Drew; Anna Hjelm; Mirjam Klepsch; Chiara Lee; John Löfblom; Jan-Willem de Gier
Optimizing membrane protein overexpression in the Escherichia coli strain Lemo21(DE3).
Journal of molecular biology 2012;423(4):648-59.
2012: Joen Luirink; Samuel Wagner; Zhong Yu; Jan-Willem de Gier
Biogenesis of inner membrane proteins in Escherichia coli.
Biochimica et biophysica acta 2012;1817(6):965-76.
2012: Wouter S P Jong; Peter Andersen; Jan-Willem de Gier; Karin de Punder; Zora Soprova; Corinne M Ten Hagen-Jongman; Nicole N Van Der Wel; Samuel Wagner; David Wickström; Joen Luirink
A structurally informed autotransporter platform for efficient heterologous protein secretion and display.
Microbial cell factories 2012;11():85.
2011: M M Klepsch; M Kovermann; C Löw; Hjalmar P Permentier; Dirk-Jan Slotboom; Jochen Balbach; Jan-Willem de Gier; F Fusetti; R P-A Berntsson
Escherichia coli peptide binding protein OppA has a preference for positively charged peptides.
Journal of molecular biology 2011;414(1):75-85.
2011: Zhong Yu; Peter van Ulsen; Wilbert Bitter; Jan-Willem de Gier; Mirjam Klepsch; Mariëlle Lavèn; Joen Luirink
Role for Escherichia coli YidD in membrane protein insertion.
Journal of bacteriology 2011;193(19):5242-51.
2011: David Wickström; Samuel Wagner; Per Simonsson; Ovidiu Ioan Pop; Louise Baars; A Jimmy Ytterberg; Klaas J van Wijk; Joen Luirink; Jan-Willem de Gier
Characterization of the consequences of YidC depletion on the inner membrane proteome of E. coli using 2D blue native/SDS-PAGE.
Journal of molecular biology 2011;409(2):124-35.
2011: David Wickström; Samuel Wagner; Louise Baars; A Jimmy Ytterberg; Mirjam Klepsch; Klaas J van Wijk; Joen Luirink; Jan-Willem de Gier
Consequences of depletion of the signal recognition particle in Escherichia coli.
The Journal of biological chemistry 2011;286(6):4598-609.
2010: Susan Schlegel; Mirjam Klepsch; Dimitra Gialama; David Wickström; Dirk Jan Slotboom; Jan-Willem de Gier
Revolutionizing membrane protein overexpression in bacteria.
Microbial biotechnology 2010;3(4):403-11.
2010: Susan Schlegel; Mirjam Klepsch; David Wickström; Samuel Wagner; Jan-Willem de Gier
Comparative analysis of cytoplasmic membrane proteomes of Escherichia coli using 2D blue native/SDS-PAGE.
Methods in molecular biology (Clifton, N.J.) 2010;619():257-69.
2009: Ana Sauri; Zora Soprova; David Wickström; Jan-Willem de Gier; Roel C Van Der Schors; August B Smit; Wouter S P Jong; Joen Luirink
The Bam (Omp85) complex is involved in secretion of the autotransporter haemoglobin protease.
Microbiology (Reading, England) 2009;155(Pt 12):3982-91.
2009: Ovidiu Ioan Pop; Zora Soprova; Gregory Koningstein; Dirk-Jan Scheffers; Peter van Ulsen; David Wickström; Jan-Willem de Gier; Joen Luirink
YidC is required for the assembly of the MscL homopentameric pore.
The FEBS journal 2009;276(17):4891-9.
2008: David Drew; Mirjam M Klepsch; Simon Newstead; Ralf Flaig; Jan-Willem de Gier; So Iwata; Konstantinos Beis
The structure of the efflux pump AcrB in complex with bile acid.
Molecular membrane biology 2008;25(8):677-82.
2008: Mirjam Klepsch; Susan Schlegel; David Wickström; Giulia Friso; Klaas J van Wijk; Jan-Olov Persson; Jan-Willem de Gier; Samuel Wagner
Immobilization of the first dimension in 2D blue native/SDS-PAGE allows the relative quantification of membrane proteomes.
Methods (San Diego, Calif.) 2008;46(2):48-53.
2008: Samuel Wagner; Mirjam M Klepsch; Susan Schlegel; Ansgar Appel; Roger Draheim; Michael Tarry; Martin Högbom; Klaas J van Wijk; Dirk-Jan Slotboom; Jan O Persson; Jan-Willem de Gier
Tuning Escherichia coli for membrane protein overexpression.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14371-6.
2008: Samuel Wagner; Ovidiu Ioan Pop; Ovidio Pop; Gert-Jan Haan; Louise Baars; Gregory Koningstein; Mirjam M Klepsch; Pierre Genevaux; Joen Luirink; Jan-Willem de Gier
Biogenesis of MalF and the MalFGK(2) maltose transport complex in Escherichia coli requires YidC.
The Journal of biological chemistry 2008;283(26):17881-90.
2008: Louise Baars; Samuel Wagner; David Wickström; Mirjam Klepsch; A Jimmy Ytterberg; Klaas J van Wijk; Jan-Willem de Gier
Effects of SecE depletion on the inner and outer membrane proteomes of Escherichia coli.
Journal of bacteriology 2008;190(10):3505-25.
2008: Edwin van Bloois; Henk L Dekker; Linda Fröderberg; Edith N G Houben; Malene L Urbanus; Chris G de Koster; Jan-Willem de Gier; Joen Luirink
Detection of cross-links between FtsH, YidC, HflK/C suggests a linked role for these proteins in quality control upon insertion of bacterial inner membrane proteins.
FEBS letters 2008;582(10):1419-24.
2007: Samuel Wagner; Louise Baars; A Jimmy Ytterberg; Anja Klussmeier; Claudia S Wagner; Olof Nord; Per-Ake Nygren; Klaas J van Wijk; Jan-Willem de Gier
Consequences of membrane protein overexpression in Escherichia coli.
Molecular & cellular proteomics : MCP 2007;6(9):1527-50.
2007: Wouter S P Jong; Corinne M Ten Hagen-Jongman; Tanneke den Blaauwen; Dirk-Jan Slotboom; Jeremy R H Tame; David Wickström; Jan-Willem de Gier; ben otto; Joen Luirink
Limited tolerance towards folded elements during secretion of the autotransporter Hbp.
Molecular microbiology 2007;63(5):1524-36.
2006: Samuel Wagner; Mirjam Lerch Bader; David Drew; Jan-Willem de Gier
Rationalizing membrane protein overexpression.
Trends in biotechnology 2006;24(8):364-71.
2006: Edwin van Bloois; Gert-Jan Haan; Jan-Willem de Gier; Bauke Oudega; Joen Luirink
Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA.
The Journal of biological chemistry 2006;281(15):10002-9.
2006: Louise Baars; A Jimmy Ytterberg; David Drew; Samuel Wagner; Claudia Thilo; Klaas J van Wijk; Jan-Willem de Gier
Defining the role of the Escherichia coli chaperone SecB using comparative proteomics.
The Journal of biological chemistry 2006;281(15):10024-34.
2006: David Drew; Mirjam Lerch; Edmund R S Kunji; Dirk-Jan Slotboom; Jan-Willem de Gier
Optimization of membrane protein overexpression and purification using GFP fusions.
Nature methods 2006;3(4):303-13.
2006: Paola Marani; Samuel Wagner; Louise Baars; Pierre Genevaux; Jan-Willem de Gier; IngMarie Nilsson; Rita Casadio; Gunnar von Heijne
New Escherichia coli outer membrane proteins identified through prediction and experimental verification.
Protein science : a publication of the Protein Society 2006;15(4):884-9.
2005: David Drew; Dirk-Jan Slotboom; Giulia Friso; Torsten Reda; Pierre Genevaux; Mikaela Rapp; Nadja M Meindl-Beinker; Wietske Lambert; Mirjam Lerch; Daniel O Daley; Klaas J van Wijk; Judy Hirst; Edmund R S Kunji; Jan-Willem de Gier
A scalable, GFP-based pipeline for membrane protein overexpression screening and purification.
Protein science : a publication of the Protein Society 2005;14(8):2011-7.
2005: Joen Luirink; Gunnar von Heijne; Edith N G Houben; Jan-Willem de Gier
Biogenesis of inner membrane proteins in Escherichia coli.
Annual review of microbiology 2005;59():329-55.
2004: Edwin van Bloois; Gert Jan Haan; Jan-Willem de Gier; Bauke Oudega; Joen Luirink
F(1)F(0) ATP synthase subunit c is targeted by the SRP to YidC in the E. coli inner membrane.
FEBS letters 2004;576(1-2):97-100.
2004: Linda Fröderberg; Edith N G Houben; Louise Baars; Joen Luirink; Jan-Willem de Gier
Targeting and translocation of two lipoproteins in Escherichia coli via the SRP/Sec/YidC pathway.
The Journal of biological chemistry 2004;279(30):31026-32.
2004: Mikaela Rapp; David Drew; Daniel O Daley; Johan Nilsson; Tiago Carvalho; Karin Melén; Jan-Willem de Gier; Gunnar von Heijne
Experimentally based topology models for E. coli inner membrane proteins.
Protein science : a publication of the Protein Society 2004;13(4):937-45.
2003: Fenglei Jiang; Minyong Chen; Liang Yi; Jan-Willem de Gier; Andreas Kuhn; Ross E Dalbey
Defining the regions of Escherichia coli YidC that contribute to activity.
The Journal of biological chemistry 2003;278(49):48965-72.
2003: Jan-Willem de Gier; Joen Luirink
The ribosome and YidC. New insights into the biogenesis of Escherichia coli inner membrane proteins.
EMBO reports 2003;4(10):939-43.
2003: David Drew; Linda Fröderberg; Louise Baars; Jan-Willem de Gier
Assembly and overexpression of membrane proteins in Escherichia coli.
Biochimica et biophysica acta 2003;1610(1):3-10.
2003: Linda Fröderberg; Edith N G Houben; James C Samuelson; Minyong Chen; Sei-Kyoung Park; Gregory J Phillips; Ross E Dalbey; Joen Luirink; Jan-Willem de Gier
Versatility of inner membrane protein biogenesis in Escherichia coli.
Molecular microbiology 2003;47(4):1015-27.
2002: Fenglei Jiang; Liang Yi; Misty Moore; Minyong Chen; Thomas Rohl; Klaas J van Wijk; Jan-Willem de Gier; Ralph Henry; Ross E Dalbey
Chloroplast YidC homolog Albino3 can functionally complement the bacterial YidC depletion strain and promote membrane insertion of both bacterial and chloroplast thylakoid proteins.
The Journal of biological chemistry 2002;277(22):19281-8.
2002: Chen-Ni Chin; Gunnar von Heijne; Jan-Willem de Gier
Membrane proteins: shaping up.
Trends in biochemical sciences 2002;27(5):231-4.
2002: Malene L Urbanus; Linda Fröderberg; David Drew; Petra Björk; Jan-Willem de Gier; Josef Brunner; Bauke Oudega; Joen Luirink
Targeting, insertion, and localization of Escherichia coli YidC.
The Journal of biological chemistry 2002;277(15):12718-23.
2002: David Drew; Dan Sjöstrand; Johan Nilsson; Thomas Urbig; Chen-Ni Chin; Jan-Willem de Gier; Gunnar von Heijne
Rapid topology mapping of Escherichia coli inner-membrane proteins by prediction and PhoA/GFP fusion analysis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2690-5.
2001: David Drew; Gunnar von Heijne; Pär Nordlund; Jan-Willem de Gier
Green fluorescent protein as an indicator to monitor membrane protein overexpression in Escherichia coli.
FEBS letters 2001;507(2):220-4.
2001: James C Samuelson; Fenglei Jiang; Liang Yi; Minyong Chen; Jan-Willem de Gier; Andreas Kuhn; Ross E Dalbey
Function of YidC for the insertion of M13 procoat protein in Escherichia coli: translocation of mutants that show differences in their membrane potential dependence and Sec requirement.
The Journal of biological chemistry 2001;276(37):34847-52.
2001: Joen Luirink; Tore Samuelsson; Jan-Willem de Gier
YidC/Oxa1p/Alb3: evolutionarily conserved mediators of membrane protein assembly.
FEBS letters 2001;501(1):1-5.
2001: Malene L Urbanus; Pier A Scotti; L Froderberg; A Saaf; Jan-Willem de Gier; Josef Brunner; J C Samuelson; Ross E Dalbey; Bauke Oudega; Joen Luirink
Sec-dependent membrane protein insertion: sequential interaction of nascent FtsQ with SecY and YidC.
EMBO reports 2001;2(6):524-9.
2001: Linda Fröderberg; T Röhl; Klaas J van Wijk; Jan-Willem de Gier
Complementation of bacterial SecE by a chloroplastic homologue.
FEBS letters 2001;498(1):52-6.
2001: Jan-Willem de Gier; Joen Luirink
Biogenesis of inner membrane proteins in Escherichia coli.
Molecular microbiology 2001;40(2):314-22.
2000: Pier A Scotti; Malene L Urbanus; Josef Brunner; Jan-Willem de Gier; Gunnar von Heijne; chris van der does; Arnold J M Driessen; Bauke Oudega; Joen Luirink
YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase.
The EMBO journal 2000;19(4):542-9.
1999: Susana Cristóbal; Pier A Scotti; Joen Luirink; Gunnar von Heijne; Jan-Willem de Gier
The signal recognition particle-targeting pathway does not necessarily deliver proteins to the sec-translocase in Escherichia coli.
The Journal of biological chemistry 1999;274(29):20068-70.
1999: Susana Cristóbal; Jan-Willem de Gier; Henrik Nielsen; Gunnar von Heijne
Competition between Sec- and TAT-dependent protein translocation in Escherichia coli.
The EMBO journal 1999;18(11):2982-90.
1998: Jan-Willem de Gier; Pier A Scotti; A Sääf; QA Valent; A Kuhn; Joen Luirink; Gunnar von Heijne
Differential use of the signal recognition particle translocase targeting pathway for inner membrane protein assembly in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14646-51.
1998: A Sääf; Magnus Monné; Jan-Willem de Gier; Gunnar von Heijne
Membrane topology of the 60-kDa Oxa1p homologue from Escherichia coli.
The Journal of biological chemistry 1998;273(46):30415-8.
1998: QA Valent; Pier A Scotti; Stephen High; Jan-Willem de Gier; Gunnar von Heijne; Georg Lentzen; Wolfgang Wintermeyer; Bauke Oudega; Joen Luirink
The Escherichia coli SRP and SecB targeting pathways converge at the translocon.
The EMBO journal 1998;17(9):2504-12.
1997: QA Valent; Jan-Willem de Gier; Gunnar von Heijne; D A Kendall; Corinne M Ten Hagen-Jongman; Bauke Oudega; Joen Luirink
Nascent membrane and presecretory proteins synthesized in Escherichia coli associate with signal recognition particle and trigger factor.
Molecular microbiology 1997;25(1):53-64.
1997: Jan-Willem de Gier; QA Valent; Gunnar von Heijne; Joen Luirink
The E. coli SRP: preferences of a targeting factor.
FEBS letters 1997;408(1):1-4.
1996: Jan-Willem de Gier; P Mansournia; QA Valent; G J Phillips; Joen Luirink; Gunnar von Heijne
Assembly of a cytoplasmic membrane protein in Escherichia coli is dependent on the signal recognition particle.
FEBS letters 1996;399(3):307-9.
1996: Jan-Willem de Gier; M Schepper; Willem N M Reijnders; S J van Dyck; D J Slotboom; A Warne; Matti Saraste; K Krab; M Finel; AH Stouthamer; Rob J M van Spanning; J van der Oost
Structural and functional analysis of aa3-type and cbb3-type cytochrome c oxidases of Paracoccus denitrificans reveals significant differences in proton-pump design.
Molecular microbiology 1996;20(6):1247-60.
1995: Rob J M van Spanning; A P de Boer; Willem N M Reijnders; Jan-Willem de Gier; C O Delorme; AH Stouthamer; Hans V Westerhoff; Nellie Harms; J van der Oost
Regulation of oxidative phosphorylation: the flexible respiratory network of Paracoccus denitrificans.
Journal of bioenergetics and biomembranes 1995;27(5):499-512.
1995: J van der Oost; M Schepper; AH Stouthamer; Hans V Westerhoff; Rob J M van Spanning; Jan-Willem de Gier
Reversed electron transfer through the bc1 complex enables a cytochrome c oxidase mutant (delta aa3/cbb3) of Paracoccus denitrificans to grow on methylamine.
FEBS letters 1995;371(3):267-70.
1995: Jan-Willem de Gier; J Van der Oost; Nellie Harms; AH Stouthamer; Rob J M van Spanning
The oxidation of methylamine in Paracoccus denitrificans.
European journal of biochemistry / FEBS 1995;229(1):148-54.
1994: J van der Oost; A P de Boer; Jan-Willem de Gier; W G Zumft; AH Stouthamer; Rob J M van Spanning
The heme-copper oxidase family consists of three distinct types of terminal oxidases and is related to nitric oxide reductase.
FEMS microbiology letters 1994;121(1):1-9.
1994: Jan-Willem de Gier; M Lübben; Willem N M Reijnders; C A Tipker; D J Slotboom; Rob J M van Spanning; AH Stouthamer; J van der Oost
The terminal oxidases of Paracoccus denitrificans.
Molecular microbiology 1994;13(2):183-96.
1992: Jan-Willem de Gier; Rob J M van Spanning; L F Oltmann; AH Stouthamer
Oxidation of methylamine by a Paracoccus denitrificans mutant impaired in the synthesis of the bc1 complex and the aa3-type oxidase. Evidence for the existence of an alternative cytochrome c oxidase in this bacterium.
FEBS letters 1992;306(1):23-6.
1991: Joen Luirink; B Duim; Jan-Willem de Gier; Bauke Oudega
Functioning of the stable signal peptide of the pCloDF13-encoded bacteriocin release protein.
Molecular microbiology 1991;5(2):393-9.