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Frank de Gruijl

Research Profile

Phenomena

Ultraviolet Rays

Disorders

Living Beings

Anatomy

Chemicals & Drugs

Physiology

Concepts & Ideas

Genes & Molecular Sequences

Genes, p53

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Publications

TOP 3
Pieter Voskamp; Rein Willemze; Jan Nico Bouwes Bavinck; Carolien A Bodmann; Abdoelwaheb El Ghalbzouri; Andreas Gaumann; Edward K Geissler; Gudrun E Koehl; Heggert G Rebel; Cornelis P Tensen; Marjolein G E Van Olderen; Frank R de Gruijl
Dietary immunosuppressants do not enhance UV-induced skin carcinogenesis, and reveal discordance between p53-mutant early clones and carcinomas.
Liesbeth Hameetman; Leon Mullenders; Cornelis P Tensen; Jan Nico Bouwes Bavinck; Suzan Commandeur; Frank R de Gruijl; Rein Willemze; Hermina C Wisgerhof; Harry Vrieling
Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients.
Frank R de Gruijl; Stan Pavel
The effects of a mid-winter 8-week course of sub-sunburn sunbed exposures on tanning, vitamin D status and colds.

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All Publications

2013: Pieter Voskamp; Rein Willemze; Jan Nico Bouwes Bavinck; Carolien A Bodmann; Abdoelwaheb El Ghalbzouri; Andreas Gaumann; Edward K Geissler; Gudrun E Koehl; Heggert G Rebel; Cornelis P Tensen; Marjolein G E Van Olderen; Frank R de Gruijl
Dietary immunosuppressants do not enhance UV-induced skin carcinogenesis, and reveal discordance between p53-mutant early clones and carcinomas.
Cancer prevention research (Philadelphia, Pa.) 2013;6(2):129-38.
2013: Liesbeth Hameetman; Leon Mullenders; Cornelis P Tensen; Jan Nico Bouwes Bavinck; Suzan Commandeur; Frank R de Gruijl; Rein Willemze; Hermina C Wisgerhof; Harry Vrieling
Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients.
BMC cancer 2013;13():58.
2012: Frank R de Gruijl; Stan Pavel
The effects of a mid-winter 8-week course of sub-sunburn sunbed exposures on tanning, vitamin D status and colds.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2012;11(12):1848-54.
2012: Suzan Commandeur; Frank R de Gruijl; Vincent van Drongelen; Abdoelwaheb El Ghalbzouri
Epidermal growth factor receptor activation and inhibition in 3D in vitro models of normal skin and human cutaneous squamous cell carcinoma.
Cancer science 2012;103(12):2120-6.
2012: P Voskamp; R Willemze; C A Bodmann; J N Bouwes Bavinck; Abdoelwaheb El Ghalbzouri; E K Geissler; G E Koehl; H G Rebel; Cornelis P Tensen; Henk J van Kranen; Frank R de Gruijl
Rapamycin impairs UV induction of mutant-p53 overexpressing cell clusters without affecting tumor onset.
International journal of cancer. Journal international du cancer 2012;131(6):1267-76.
2012: H G Rebel; G C van de Glind; C A Bodmann; Frank R de Gruijl
UV-induced ablation of the epidermal basal layer including p53-mutant clones resets UV carcinogenesis showing squamous cell carcinomas to originate from interfollicular epidermis.
Carcinogenesis 2012;33(3):714-20.
2012: Siamaque Kazem; Linda Struijk; Els van der Meijden; Frank R de Gruijl; Mariet C W Feltkamp
Human papillomavirus 8 E6 disrupts terminal skin differentiation and prevents pro-Caspase-14 cleavage.
Virus research 2012;163(2):609-16.
2011: Suzan Commandeur; Frank R de Gruijl; Suet Huy Ho; Cornelis P Tensen; Rein Willemze; Abdoelwaheb El Ghalbzouri
Functional characterization of cancer-associated fibroblasts of human cutaneous squamous cell carcinoma.
Experimental dermatology 2011;20(9):737-42.
2011: Frank R de Gruijl
Sufficient vitamin D from casual sun exposure?
Photochemistry and photobiology 2011;87(3):598-601.
2011: Mary Norval; R M Lucas; Anthony P Cullen; Frank R de Gruijl; Longstreth Janice; Yukio Takizawa; Jan C van der Leun
The human health effects of ozone depletion and interactions with climate change.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2011;10(2):199-225.
2010: Frank R de Gruijl; G E Koehl; P Voskamp; A Strik; H G Rebel; A Gaumann; Johan W de Fijter; Cornelis P Tensen; Jan Nico Bouwes Bavinck; E K Geissler
Early and late effects of the immunosuppressants rapamycin and mycophenolate mofetil on UV carcinogenesis.
International journal of cancer. Journal international du cancer 2010;127(4):796-804.
2010: Lesley E Rhodes; Michael Bock; A Soe Janssens; Tsui C Ling; Lina Anastasopoulou; Christina Antoniou; François Aubin; Thomas Bruckner; Brigitte Faivre; Neil K Gibbs; Christer Jansen; Stan Pavel; Alexander J Stratigos; Frank R de Gruijl; Thomas L Diepgen
Polymorphic light eruption occurs in 18% of Europeans and does not show higher prevalence with increasing latitude: multicenter survey of 6,895 individuals residing from the Mediterranean to Scandinavia.
The Journal of investigative dermatology 2010;130(2):626-8.
2010: Mary Norval; Lars Olof Björn; Frank R de Gruijl
Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct?
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2010;9(1):11-7.
2009: Anastasia Tsaalbi-Shtylik; Johan W A Verspuy; Jacob G Jansen; Heggert Rebel; Leone M Carlée; Martin A van der Valk; Jos Jonkers; Frank R de Gruijl; Niels De Wind
Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(51):21836-41.
2009: Suzan Commandeur; Frank R de Gruijl; Rein Willemze; Cornelis P Tensen; Abdoelwaheb El Ghalbzouri
An in vitro three-dimensional model of primary human cutaneous squamous cell carcinoma.
Experimental dermatology 2009;18(10):849-56.
2009: Frank R de Gruijl
Protein kinase Cepsilon reveals importance of extrinsic apoptosis in preventing UV carcinogenesis.
The Journal of investigative dermatology 2009;129(8):1853-6.
2009: Artiena Soe Janssens; Stan Pavel; C P Tensen; M B M Teunissen; Jacoba J Out-Luiting; Rein Willemze; Frank R de Gruijl
Reduced IL-1Ra/IL-1 ratio in ultraviolet B-exposed skin of patients with polymorphic light eruption.
Experimental dermatology 2009;18(3):212-7.
2009: Alex Pines; Claude Backendorf; Sergey Alekseev; Jacob G Jansen; Frank R de Gruijl; Harry Vrieling; Leon H F Mullenders
Differential activity of UV-DDB in mouse keratinocytes and fibroblasts: impact on DNA repair and UV-induced skin cancer.
DNA repair 2009;8(2):153-61.
2009: Frank R de Gruijl; Pieter Voskamp
Photocarcinogenesis--DNA damage and gene mutations.
Cancer treatment and research 2009;146():101-8.
2009: Anthony Andrady; Pieter J Aucamp; Alkiviadis Bais; Carlos L Ballaré; Lars Olof Björn; Janet F Bornman; Martyn Caldwell; Anthony P Cullen; David J Erickson; Frank R de Gruijl; Donat-P Häder; Mohammad Ilyas; G Kulandaivelu; H D Kumar; Longstreth Janice; Richard L McKenzie; Mary Norval; Nigel Paul; Halim Hamid Redhwi; Raymond C Smith; Keith R Solomon; Barbara Sulzberger; Yukio Takizawa; Xiaoyan Tang; Alan H Teramura; Ayako Torikai; Jan C van der Leun; Stephen R Wilson; Robert C Worrest; Richard G Zepp
Environmental effects of ozone depletion and its interactions with climate change: progress report, 2008.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2009;8(1):13-22.
2008: Linda Struijk; Els van der Meijden; Siamaque Kazem; Jan ter Schegget; Frank R de Gruijl; Renske D M Steenbergen; Mariet C W Feltkamp
Specific betapapillomaviruses associated with squamous cell carcinoma of the skin inhibit UVB-induced apoptosis of primary human keratinocytes.
The Journal of general virology 2008;89(Pt 9):2303-14.
2008: Jan C van der Leun; Rubén D Piacentini; Frank R de Gruijl
Climate change and human skin cancer.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2008;7(6):730-3.
2008: Y G L De Graaf; Heggert Rebel; Abdoel Elghalbzouri; Patricia Cramers; Ruud G L Nellen; Rein Willemze; Jan N Bouwes Bavinck; Frank R de Gruijl
More epidermal p53 patches adjacent to skin carcinomas in renal transplant recipients than in immunocompetent patients: the role of azathioprine.
Experimental dermatology 2008;17(4):349-55.
2008: Frank R de Gruijl; Heggert Rebel
Early events in UV carcinogenesis--DNA damage, target cells and mutant p53 foci.
Photochemistry and photobiology 2008;84(2):382-7.
2008: Frank R de Gruijl
UV-induced immunosuppression in the balance.
Photochemistry and photobiology 2008;84(1):2-9.
2007: Joanne G W Nijhof; Aat M Mulder; Ewoud N Speksnijder; Esther M Hoogervorst; Leon H F Mullenders; Frank R de Gruijl
Growth stimulation of UV-induced DNA damage retaining epidermal basal cells gives rise to clusters of p53 overexpressing cells.
DNA repair 2007;6(11):1642-50.
2007: Artiena Soe Janssens; Stan Pavel; Tsui Ling; Sandra Maria Winhoven; Nikoletta Anastasopoulou; Alexander J Stratigos; Christina Antoniou; Thomas L Diepgen; Frank R de Gruijl; Lesley E Rhodes
Susceptibility to UV-A and UV-B provocation does not correlate with disease severity of polymorphic light eruption.
Archives of dermatology 2007;143(5):599-604.
2007: Joanne G W Nijhof; Carina van Pelt; Adriaan A Mulder; David L Mitchell; Leon H F Mullenders; Frank R de Gruijl
Epidermal stem and progenitor cells in murine epidermis accumulate UV damage despite NER proficiency.
Carcinogenesis 2007;28(4):792-800.
2007: Mary Norval; Anthony P Cullen; Frank R de Gruijl; Longstreth Janice; Yukio Takizawa; R M Lucas; F P Noonan; Jan C van der Leun
The effects on human health from stratospheric ozone depletion and its interactions with climate change.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2007;6(3):232-51.
2006: Judith Jans; george garinis; Wouter Schul; Adri van Oudenaren; Michael J Moorhouse; Marcel Smid; Yurda-Gul Sert; Albertina van der Velde; Yvonne Rijksen; Frank R de Gruijl; Peter van der Spek; Akira Yasui; Jan H J Hoeijmakers; Pieter J M Leenen; Gijsbertus T J van der Horst
Differential role of basal keratinocytes in UV-induced immunosuppression and skin cancer.
Molecular and cellular biology 2006;26(22):8515-26.
2006: Joanne G W Nijhof; Kristin Braun; Adam Giangreco; Carina van Pelt; Hiroshi Kawamoto; Richard L Boyd; Rein Willemze; Leon H F Mullenders; Fiona M Watt; Frank R de Gruijl; Willem van Ewijk
The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells.
Development (Cambridge, England) 2006;133(15):3027-37.
2006: Tsui C Ling; Helen L Richards; Artiena Soe Janssens; Lina Anastassopoulou; Christina Antoniou; Francois Aubin; Thomas L Diepgen; Rosemary Fazakerley; Frank R de Gruijl; Christer T Jansen; Stan Pavel; Andrew Smedley; Alexander J Stratigos; Ann R Webb; Neil K Gibbs; Lesley E Rhodes
Seasonal and latitudinal impact of polymorphic light eruption on quality of life.
The Journal of investigative dermatology 2006;126(7):1648-51.
2006: Frank R de Gruijl; Leon H F Mullenders; Gerdine J Stout
Elimination of keratinocytes stagnant in s-phase through epidermal turnover instead of in situ apoptosis.
Cell cycle (Georgetown, Tex.) 2006;5(6):565-6.
2006: Arne van Schanke; Gemma M C A L van Venrooij; Marjan J Jongsma; H Alexander Banus; Leon H F Mullenders; Henk J van Kranen; Frank R de Gruijl
Induction of nevi and skin tumors in Ink4a/Arf Xpa knockout mice by neonatal, intermittent, or chronic UVB exposures.
Cancer research 2006;66(5):2608-15.
2006: Sergei A Snopov; L Roza; Frank R de Gruijl
[Retarded excision of pyrimidine dimers in human unstimulated lymphocytes].
Tsitologiia 2006;48(11):958-66.
2005: Gerdine J Stout; Daniel Westdijk; Dennis M Calkhoven; Olaf Pijper; Claude Backendorf; Rein Willemze; Leon H F Mullenders; Frank R de Gruijl
Epidermal transit of replication-arrested, undifferentiated keratinocytes in UV-exposed XPC mice: an alternative to in situ apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):18980-5.
2005: Heggert Rebel; Nicolien R Kram; Anja Westerman; Sander Banus; Henk J van Kranen; Frank R de Gruijl
Relationship between UV-induced mutant p53 patches and skin tumours, analysed by mutation spectra and by induction kinetics in various DNA-repair-deficient mice.
Carcinogenesis 2005;26(12):2123-30.
2005: Claude Backendorf; Jan de Wit; Marijke van Oosten; Gerdine J Stout; James R Mitchell; Anne-Marijke Borgstein; Gijsbertus T J van der Horst; Frank R de Gruijl; Jaap Brouwer; Leon H F Mullenders; Jan H J Hoeijmakers
Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice.
DNA repair 2005;4(11):1325-36.
2005: Sergey Alekseev; Hanneke Kool; Heggert Rebel; Maria Fousteri; Jill Moser; Claude Backendorf; Frank R de Gruijl; Harry Vrieling; Leon H F Mullenders
Enhanced DDB2 expression protects mice from carcinogenic effects of chronic UV-B irradiation.
Cancer research 2005;65(22):10298-306.
2005: Albert A van Zeeland; Maaike P G Vreeswijk; Frank R de Gruijl; Henk J van Kranen; Harry Vrieling; Leon F H Mullenders
Transcription-coupled repair: impact on UV-induced mutagenesis in cultured rodent cells and mouse skin tumors.
Mutation research 2005;577(1-2):170-8.
2005: Artiena Soe Janssens; Stan Pavel; Jacoba J Out-Luiting; Rein Willemze; Frank R de Gruijl
Normalized ultraviolet (UV) induction of Langerhans cell depletion and neutrophil infiltrates after artificial UVB hardening of patients with polymorphic light eruption.
The British journal of dermatology 2005;152(6):1268-74.
2005: Y G L De Graaf; Daniel Schiefer; Anke Redeker; Bert Jan Vermeer; Jan Nico Bouwes Bavinck; Rein Willemze; Frank R de Gruijl; Sjoerd H van der burg
p53-specific serum antibodies are not associated with a history of skin carcinoma in renal transplant recipients and immunocompetent individuals.
Journal of dermatological science 2005;38(3):228-30.
2005: Henk J van Kranen; Anja Westerman; Rob J W Berg; Nicolien R Kram; Coen F van Kreijl; Piet W Wester; Frank R de Gruijl
Dose-dependent effects of UVB-induced skin carcinogenesis in hairless p53 knockout mice.
Mutation research 2005;571(1-2):81-90.
2005: Esther de Vries; Lonneke V van de Poll-Franse; WJ Louwman; Frank R de Gruijl; Dorry Boll
Predictions of skin cancer incidence in the Netherlands up to 2015.
The British journal of dermatology 2005;152(3):481-8.
2005: Anthony Andrady; Pieter J Aucamp; Alkiviadis F Bais; Carlos L Ballaré; Lars Olof Björn; Janet F Bornman; Martyn Caldwell; Terry V Callaghan; Anthony P Cullen; David J Erickson; Frank R de Gruijl; Donat-P Häder; Mohammad Ilyas; G Kulandaivelu; HD Kumar; Longstreth Janice; Richard L McKenzie; Mary Norval; Halim Hamid Redhwi; Raymond C Smith; Keith R Solomon; Barbara Sulzberger; Yukio Takizawa; Xiaoyan Tang; Alan H Teramura; Ayako Torikai; Jan C van der Leun; Stephen R Wilson; Robert C Worrest; Richard G Zepp
Environmental effects of ozone depletion and its interactions with climate change: progress report, 2004.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2005;4(2):177-84.
2005: Artiena Soe Janssens; Eileen E L O Lashley; Coby J Out-Luiting; Rein Willemze; Stan Pavel; Frank R de Gruijl
UVB-induced leucocyte trafficking in the epidermis of photosensitive lupus erythematosus patients: normal depletion of Langerhans cells.
Experimental dermatology 2005;14(2):138-42.
2005: Judith Jans; Wouter Schul; Yurda-Gul Sert; Yvonne Rijksen; Heggert Rebel; Andre P M Eker; Satoshi Nakajima; Harry van Steeg; Frank R de Gruijl; Akira Yasui; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Powerful skin cancer protection by a CPD-photolyase transgene.
Current biology : CB 2005;15(2):105-15.
2005: Marijke van Oosten; Gerdine J Stout; Claude Backendorf; Heggert Rebel; Niels De Wind; Firouz Darroudi; Henk J van Kranen; Frank R de Gruijl; Leon H F Mullenders
Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes.
DNA repair 2005;4(1):81-9.
2005: Arne van Schanke; Marjan J Jongsma; Roel Bisschop; Gemma M C A L van Venrooij; Heggert Rebel; Frank R de Gruijl
Single UVB overexposure stimulates melanocyte proliferation in murine skin, in contrast to fractionated or UVA-1 exposure.
The Journal of investigative dermatology 2005;124(1):241-7.
2005: Frank R de Gruijl; Henk J van Kranen; Arne van Schanke
UV exposure, genetic targets in melanocytic tumors and transgenic mouse models.
Photochemistry and photobiology 2005;81(1):52-64.
2004: Esther de Vries; Marieke W J Louwman; Maarten Bastiaens; Frank R de Gruijl; Dorry Boll
Rapid and continuous increases in incidence rates of basal cell carcinoma in the southeast Netherlands since 1973.
The Journal of investigative dermatology 2004;123(4):634-8.
2004: Fabian Termorshuizen; Mariet C W Feltkamp; Linda Struijk; Frank R de Gruijl; Jan Nico Bouwes Bavinck; Henk Van Loveren
Sunlight exposure and (sero)prevalence of epidermodysplasia verruciformis-associated human papillomavirus.
The Journal of investigative dermatology 2004;122(6):1456-62.
2004: Nadem Soufir; Sophie Queille; Karine Mollier; Emeric ROUX; Alain Sarasin; Frank R de Gruijl; Anny Fourtanier; Leela Daya-Grosjean; Nicole Basset-Seguin
INK4a-ARF mutations in skin carcinomas from UV irradiated hairless mice.
Molecular carcinogenesis 2004;39(4):195-8.
2004: Wendy Kölgen; Marjan van Meurs; Marjan Jongsma; Huib van Weelden; C A F M Bruijnzeel-Koomen; Edward F Knol; Willem A van Vloten; Jon Laman; Frank R de Gruijl
Differential expression of cytokines in UV-B-exposed skin of patients with polymorphous light eruption: correlation with Langerhans cell migration and immunosuppression.
Archives of dermatology 2004;140(3):295-302.
2004: Sergei A Snopov; Frank R de Gruijl; Len Roza; Jan C van der Leun
Immunochemical study of DNA modifications in the nuclei of UV-damaged lymphocytes.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2004;3(1):85-90.
2003: Wendy Kölgen; Harry van Steeg; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Willem A van Vloten; Frank R de Gruijl; Johan Garssen
Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression.
The Journal of investigative dermatology 2003;121(4):751-6.
2003: Cornelis Kennedy; Chris D Bajdik; Rein Willemze; Frank R de Gruijl; Jan N Bouwes Bavinck
The influence of painful sunburns and lifetime sun exposure on the risk of actinic keratoses, seborrheic warts, melanocytic nevi, atypical nevi, and skin cancer.
The Journal of investigative dermatology 2003;120(6):1087-93.
2003: Annemarie Sleijffers; Berran Yucesoy; Michael Kashon; Johan Garssen; Frank R de Gruijl; Greet J Boland; Jan van Hattum; Michael I Luster; Henk Van Loveren
Cytokine polymorphisms play a role in susceptibility to ultraviolet B-induced modulation of immune responses after hepatitis B vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3423-8.
2003: Annemarie Sleijffers; Arthur Kammeyer; Frank R de Gruijl; Greet J Boland; Jan van Hattum; Willem A van Vloten; Henk Van Loveren; Marcel B M Teunissen; Johan Garssen
Epidermal cis-urocanic acid levels correlate with lower specific cellular immune responses after hepatitis B vaccination of ultraviolet B-exposed humans.
Photochemistry and photobiology 2003;77(3):271-5.
2003: Frank R de Gruijl; Longstreth Janice; Mary Norval; Anthony P Cullen; Harry Slaper; Margaret L Kripke; Yukio Takizawa; Jan C van der Leun
Health effects from stratospheric ozone depletion and interactions with climate change.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2003;2(1):16-28.
2002: Frank R de Gruijl
Photocarcinogenesis: UVA vs. UVB radiation.
Skin pharmacology and applied skin physiology 2002;15(5):316-20.
2002: Frank R de Gruijl
Ultraviolet radiation and tumor immunity.
Methods (San Diego, Calif.) 2002;28(1):122-9.
2002: Berran Yucesoy; Annemarie Sleijffers; Michael Kashon; Johan Garssen; Frank R de Gruijl; Greet J Boland; Jan van Hattum; Petia P Simeonova; Michael I Luster; Henk Van Loveren
IL-1beta gene polymorphisms influence hepatitis B vaccination.
Vaccine 2002;20(25-26):3193-6.
2002: Frank R de Gruijl; Jan C van der Leun
Physical variables in experimental photocarcinogenesis and quantitative relationships between stages of tumor development.
Frontiers in bioscience : a journal and virtual library 2002;7():d1525-30.
2002: Jan C van der Leun; Frank R de Gruijl
Climate change and skin cancer.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2002;1(5):324-6.
2002: Annemarie Sleijffers; Johan Garssen; Frank R de Gruijl; Greet J Boland; Jan van Hattum; Willem A van Vloten; Henk Van Loveren
UVB exposure impairs immune responses after hepatitis B vaccination in two different mouse strains.
Photochemistry and photobiology 2002;75(5):541-6.
2002: Wendy Kölgen; Hilde Both; Huib van Weelden; Kees L H Guikers; C A F M Bruijnzeel-Koomen; Edward F Knol; Willem A van Vloten; Frank R de Gruijl
Epidermal langerhans cell depletion after artificial ultraviolet B irradiation of human skin in vivo: apoptosis versus migration.
The Journal of investigative dermatology 2002;118(5):812-7.
2002: Heggert Rebel; Harry van Steeg; Rudolf B Beems; Ron Schouten; Frank R de Gruijl; Carrol Terleth
Suppression of UV carcinogenesis by difluoromethylornithine in nucleotide excision repair-deficient Xpa knockout mice.
Cancer research 2002;62(5):1338-42.
2002: Fabian Termorshuizen; Johan Garssen; Mary Norval; Leena M Koulu; Jarmo Laihia; L Leino; Christer T Jansen; Frank R de Gruijl; Neil K Gibbs; C De Simone; Henk Van Loveren
A review of studies on the effects of ultraviolet irradiation on the resistance to infections: evidence from rodent infection models and verification by experimental and observational human studies.
International immunopharmacology 2002;2(2-3):263-75.
2002: Frank R de Gruijl
p53 mutations as a marker of skin cancer risk: comparison of UVA and UVB effects.
Experimental dermatology 2002;11 Suppl 1():37-9.
2001: Annemarie Sleijffers; Johan Garssen; Frank R de Gruijl; Greet J Boland; Jan van Hattum; Willem A van Vloten; Henk Van Loveren
Influence of ultraviolet B exposure on immune responses following hepatitis B vaccination in human volunteers.
The Journal of investigative dermatology 2001;117(5):1144-50.
2001: Frank R de Gruijl; Henk J van Kranen; Leon H F Mullenders
UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer.
Journal of photochemistry and photobiology. B, Biology 2001;63(1-3):19-27.
2001: Johan Garssen; Frank R de Gruijl; DQ Mol; Arja de Klerk; Paul Roholl; Henk Van Loveren
UVA exposure affects UVB and cis-urocanic acid-induced systemic suppression of immune responses in Listeria monocytogenes-infected Balb/c mice.
Photochemistry and photobiology 2001;73(4):432-8.
2001: Heggert Rebel; L O Mosnier; Rob J W Berg; A Westerman-de Vries; Harry van Steeg; Henk J van Kranen; Frank R de Gruijl
Early p53-positive foci as indicators of tumor risk in ultraviolet-exposed hairless mice: kinetics of induction, effects of DNA repair deficiency, and p53 heterozygosity.
Cancer research 2001;61(3):977-83.
2000: Marijke van Oosten; Heggert Rebel; Errol C Friedberg; Harry van Steeg; Gijsbertus T J van der Horst; Henk J van Kranen; Anja Westerman; Albert A van Zeeland; Leon H F Mullenders; Frank R de Gruijl
Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11268-73.
2000: Frank R de Gruijl; Jan C van der Leun
Environment and health: 3. Ozone depletion and ultraviolet radiation.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2000;163(7):851-5.
2000: Johan Garssen; Harry van Steeg; Frank R de Gruijl; Jan de Boer; Gijsbertus T J van der Horst; Henk J van Kranen; Henk Van Loveren; M Van Dijk; A Fluitman; Geert Weeda; Jan H J Hoeijmakers
Transcription-coupled and global genome repair differentially influence UV-B-induced acute skin effects and systemic immunosuppression.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6199-205.
2000: Rob J W Berg; Heggert Rebel; Gijsbertus T J van der Horst; Henk J van Kranen; Leon H F Mullenders; Willem A van Vloten; Frank R de Gruijl
Impact of global genome repair versus transcription-coupled repair on ultraviolet carcinogenesis in hairless mice.
Cancer research 2000;60(11):2858-63.
1999: Henk J van Kranen; Frank R de Gruijl
Mutations in cancer genes of UV-induced skin tumors of hairless mice.
Journal of epidemiology / Japan Epidemiological Association 1999;9(6 Suppl):S58-65.
1999: Jan de Boer; Harry van Steeg; Rob J W Berg; Johan Garssen; Jan de Wit; C T van Oostrum; Rudolf B Beems; Gijsbertus T J van der Horst; Coen F van Kreijl; Frank R de Gruijl; Dirk Bootsma; Jan H J Hoeijmakers; Geert Weeda
Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition.
Cancer research 1999;59(14):3489-94.
1999: Johan Garssen; Rob Vandebriel; Frank R de Gruijl; D A Wolvers; M Van Dijk; A Fluitman; Henk Van Loveren
UVB exposure-induced systemic modulation of Th1- and Th2-mediated immune responses.
Immunology 1999;97(3):506-14.
1999: Wendy Kölgen; Huib van Weelden; S Den Hengst; Kees L H Guikers; Rebecca C M Kiekens; Edward F Knol; C A F M Bruijnzeel-Koomen; Willem A van Vloten; Frank R de Gruijl
CD11b+ cells and ultraviolet-B-resistant CD1a+ cells in skin of patients with polymorphous light eruption.
The Journal of investigative dermatology 1999;113(1):4-10.
1999: David L Mitchell; Rüdiger Greinert; Frank R de Gruijl; Kees L H Guikers; Eckard W Breitbart; Michelle Byrom; M M Gallmeier; MG Lowery; B Volkmer
Effects of chronic low-dose ultraviolet B radiation on DNA damage and repair in mouse skin.
Cancer research 1999;59(12):2875-84.
1999: Wim G Goettsch; Johan Garssen; Frank R de Gruijl; PM Dortant; Henk Van Loveren
Methods for exposure of laboratory animals to ultraviolet radiation.
Laboratory animals 1999;33(1):58-67.
1998: Longstreth Janice; Frank R de Gruijl; Margaret L Kripke; S Abseck; F Arnold; Harry Slaper; G Velders; Y Takizawa; Jan C van der Leun
Health risks.
Journal of photochemistry and photobiology. B, Biology 1998;46(1-3):20-39.
1998: Frank R de Gruijl; Rob J W Berg
In situ molecular dosimetry and tumor risk: UV-induced DNA damage and tumor latency time.
Photochemistry and photobiology 1998;68(4):555-60.
1998: Annemieke de Vries; Rob J W Berg; Susan W P Wijnhoven; Anja Westerman; Piet W Wester; Coen F van Kreijl; PJ Capel; Frank R de Gruijl; Henk J van Kranen; Harry van Steeg
XPA-deficiency in hairless mice causes a shift in skin tumor types and mutational target genes after exposure to low doses of U.V.B.
Oncogene 1998;16(17):2205-12.
1998: Rob J W Berg; Henk Ruven; A T Sands; Frank R de Gruijl; Leon H F Mullenders
Defective global genome repair in XPC mice is associated with skin cancer susceptibility but not with sensitivity to UVB induced erythema and edema.
The Journal of investigative dermatology 1998;110(4):405-9.
1998: Johan Garssen; Mary Norval; Ali A El-Ghorr; Neil K Gibbs; C D Jones; Decio Cerimele; C De Simone; Sergio Caffieri; Francesco Dall'Acqua; Frank R de Gruijl; Y Sontag; Henk Van Loveren
Estimation of the effect of increasing UVB exposure on the human immune system and related resistance to infectious diseases and tumours.
Journal of photochemistry and photobiology. B, Biology 1998;42(3):167-79.
1998: Wim G Goettsch; J Garssen; Wout Slob; Frank R de Gruijl; Henk Van Loveren
Risk assessment for the harmful effects of UVB radiation on the immunological resistance to infectious diseases.
Environmental health perspectives 1998;106(2):71-7.
1997: J M de Laat; S Seité; M Groenendijk; Willem A van Vloten; Frank R de Gruijl
Chronic UVA (365-nm) irradiation induced scratching in hairless mice: dose-time dependency and the effect of ketanserin.
Experimental dermatology 1997;6(6):292-7.
1997: Gijsbertus T J van der Horst; Harry van Steeg; Rob J W Berg; Alain van Gool; Jan de Wit; Geert Weeda; Hans Morreau; Rudolf B Beems; Coen F van Kreijl; Frank R de Gruijl; Dirk Bootsma; Jan H J Hoeijmakers
Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition.
Cell 1997;89(3):425-35.
1997: A de Laat; Jan C van der Leun; Frank R de Gruijl
Carcinogenesis induced by UVA (365-nm) radiation: the dose-time dependence of tumor formation in hairless mice.
Carcinogenesis 1997;18(5):1013-20.
1997: Nicolas Dumaz; Henk J van Kranen; Annemieke de Vries; Rob J W Berg; Piet W Wester; Coen F van Kreijl; Alain Sarasin; Leela Daya-Grosjean; Frank R de Gruijl
The role of UV-B light in skin carcinogenesis through the analysis of p53 mutations in squamous cell carcinomas of hairless mice.
Carcinogenesis 1997;18(5):897-904.
1997: Norbert Wikonkál; Rob J W Berg; Christian W van Haselen; Irén Horkay; Eva Remenyik; A Begany; János Hunyadi; Willem A van Vloten; Frank R de Gruijl
bcl-2 vs p53 protein expression and apoptotic rate in human nonmelanoma skin cancers.
Archives of dermatology 1997;133(5):599-602.
1997: A de Laat; E D Kroon; Frank R de Gruijl
Cell cycle effects and concomitant p53 expression in hairless murine skin after longwave UVA (365 nm) irradiation: a comparison with UVB irradiation.
Photochemistry and photobiology 1997;65(4):730-5.
1997: Henk J van Kranen; A de Laat; J van de Ven; Piet W Wester; Annemieke de Vries; Rob J W Berg; Coen F van Kreijl; Frank R de Gruijl
Low incidence of p53 mutations in UVA (365-nm)-induced skin tumors in hairless mice.
Cancer research 1997;57(7):1238-40.
1997: Rob J W Berg; Annemieke de Vries; Harry van Steeg; Frank R de Gruijl
Relative susceptibilities of XPA knockout mice and their heterozygous and wild-type littermates to UVB-induced skin cancer.
Cancer research 1997;57(4):581-4.
1997: Y Sontag; Peter A Steerenberg; Johan Garssen; Henk Van Loveren; Jan C van der Leun; Willem A van Vloten; Frank R de Gruijl
Time and dose dependence of acceptance of UV-induced syngeneic tumor implants in chronically UV-exposed hairless mice.
Photochemistry and photobiology 1997;65(2):342-6.
1996: H Slaper; G J Velders; J S Daniel; Frank R de Gruijl; J C van der Leun
Estimates of ozone depletion and skin cancer incidence to examine the Vienna Convention achievements.
Nature 1996;384(6606):256-8.
1996: Wim G Goettsch; Johan Garssen; Frank R de Gruijl; Henk Van Loveren
UVB-induced decreased resistance to Trichinella spiralis in the rat is related to impaired cellular immunity.
Photochemistry and photobiology 1996;64(3):581-5.
1996: Johan Garssen; Wim G Goettsch; Frank R de Gruijl; Wout Slob; Henk Van Loveren
Risk assessment of UVB effects on resistance to infectious diseases.
Photochemistry and photobiology 1996;64(2):269-74.
1996: Wim G Goettsch; Johan Garssen; A de Klerk; T M Herremans; PM Dortant; Frank R de Gruijl; Henk Van Loveren
Effects of ultraviolet-B exposure on the resistance to Listeria monocytogenes in the rat.
Photochemistry and photobiology 1996;63(5):672-9.
1996: A de Laat; M van Tilburg; Jan C van der Leun; Willem A van Vloten; Frank R de Gruijl
Cell cycle kinetics following UVA irradiation in comparison to UVB and UVC irradiation.
Photochemistry and photobiology 1996;63(4):492-7.
1996: Frank R de Gruijl
Photobiology of photocarcinogenesis.
Photochemistry and photobiology 1996;63(4):372-5.
1996: Rob J W Berg; Henk J van Kranen; H G Rebel; Annemieke de Vries; Willem A van Vloten; Coen F van Kreijl; Jan C van der Leun; Frank R de Gruijl
Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):274-8.
1996: J M de Laat; Frank R de Gruijl
The role of UVA in the aetiology of non-melanoma skin cancer.
Cancer surveys 1996;26():173-91.
1995: Rob J W Berg; S C de Bueger; K Guikers; Huib van Weelden; Willem A van Vloten; Jan C van der Leun; Frank R de Gruijl
Induction and disappearance of thymine dimers in human skin exposed to UVB radiation: flow cytometric measurements in replicating and nonreplicating epidermal cells.
Photochemistry and photobiology 1995;62(6):970-5.
1995: Rob J W Berg; A de Laat; L Roza; Jan C van der Leun; Frank R de Gruijl
Substitution of equally carcinogenic UV-A for UV-B irradiations lowers epidermal thymine dimer levels during skin cancer induction in hairless mice.
Carcinogenesis 1995;16(10):2455-9.
1995: Annemieke de Vries; Conny Th M van Oostrom; Frans M A Hofhuis; PM Dortant; Rob J W Berg; Frank R de Gruijl; Piet W Wester; Coen F van Kreijl; PJ Capel; Harry van Steeg; S J Verbeek
Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.
Nature 1995;377(6545):169-73.
1995: Frank R de Gruijl; Paul Donald Forbes
UV-induced skin cancer in a hairless mouse model.
BioEssays : news and reviews in molecular, cellular and developmental biology 1995;17(7):651-60.
1995: Henk J van Kranen; Frank R de Gruijl; Annemieke de Vries; Y Sontag; Piet W Wester; H C Senden; E Rozemuller; Coen F van Kreijl
Frequent p53 alterations but low incidence of ras mutations in UV-B-induced skin tumors of hairless mice.
Carcinogenesis 1995;16(5):1141-7.
1995: Y Sontag; C L Guikers; Arie A Vink; Frank R de Gruijl; Henk Van Loveren; Johan Garssen; L Roza; Margaret L Kripke; Jan C van der Leun; Willem A van Vloten
Cells with UV-specific DNA damage are present in murine lymph nodes after in vivo UV irradiation.
The Journal of investigative dermatology 1995;104(5):734-8.
1995: S A Snopov; Rob J W Berg; Huib van Weelden; K A Samoilova; Jan C van der Leun; Frank R de Gruijl
Molecular dosimetry by flow cytometric detection of thymine dimers in mononuclear cells from extracorporally UV-irradiated blood.
Journal of photochemistry and photobiology. B, Biology 1995;28(1):33-7.
1995: Frank R de Gruijl
Action spectrum for photocarcinogenesis.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1995;139():21-30.
1994: M A Grijzenhout; M I Aarts-Riemens; Frank R de Gruijl; Huib van Weelden; H C van Prooijen
UVB irradiation of human platelet concentrates does not prevent HLA alloimmunization in recipients.
Blood 1994;84(10):3524-31.
1994: Wim G Goettsch; Johan Garssen; M H Hurks; Frank R de Gruijl; Henk Van Loveren
Effects of in vitro exposure to ultraviolet radiation on the functional activity of lymphocytes, with emphasis on susceptibility of different species.
Photochemistry and photobiology 1994;60(4):373-9.
1994: Wim G Goettsch; Johan Garssen; Frank R de Gruijl; Henk Van Loveren
Effects of UV-B on the resistance against infectious diseases.
Toxicology letters 1994;72(1-3):359-63.
1994: Y Sontag; Johan Garssen; Frank R de Gruijl; Jan C van der Leun; Willem A van Vloten; Henk Van Loveren
Ultraviolet radiation--induced impairment of the early initiating and the late effector phases of contact hypersensitivity to picrylchloride: regulation by different mechanisms.
The Journal of investigative dermatology 1994;102(6):923-7.
1994: Wim G Goettsch; Johan Garssen; A Deijns; Frank R de Gruijl; Henk Van Loveren
UV-B exposure impairs resistance to infection by Trichinella spiralis.
Environmental health perspectives 1994;102(3):298-301.
1994: Arie A Vink; Y Sontag; Frank R de Gruijl; L Roza; RA Baan
Immunochemical detection of cyclobutane thymine dimers in epidermal Langerhans cells of ultraviolet B-irradiated hairless mice.
Photodermatology, photoimmunology & photomedicine 1994;10(1):8-12.
1993: Rob J W Berg; Frank R de Gruijl; Jan C van der Leun
Interaction between ultraviolet A and ultraviolet B radiations in skin cancer induction in hairless mice.
Cancer research 1993;53(18):4212-7.
1993: Arie A Vink; Rob J W Berg; Frank R de Gruijl; Paul H M Lohman; L Roza; RA Baan
Detection of thymine dimers in suprabasal and basal cells of chronically UV-B exposed hairless mice.
The Journal of investigative dermatology 1993;100(6):795-9.
1993: Wim G Goettsch; Johan Garssen; Frank R de Gruijl; Henk Van Loveren
UV-B and the immune system. A review with special emphasis on T cell-mediated immunity.
Thymus 1993;21(2):93-114.
1993: Rob J W Berg; Frank R de Gruijl; L Roza; Jan C van der Leun
Flow cytometric immunofluorescence assay for quantification of cyclobutyldithymine dimers in separate phases of the cell cycle.
Carcinogenesis 1993;14(1):103-6.
1993: Frank R de Gruijl; Henricus Sterenborg; Paul Donald Forbes; R E Davies; C Cole; G Kelfkens; Huib van Weelden; H Slaper; Jan C van der Leun
Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice.
Cancer research 1993;53(1):53-60.
1993: J C van der Leun; Frank R de Gruijl; M Tevini; R C Worrest
Ultraviolet carcinogenesis: environmental effects of ozone depletion.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1993;128():263-7.
1992: G Kelfkens; Frank R de Gruijl; Jan C van der Leun
The influence of ventral UVA exposure on subsequent tumorigenesis in mice by UVA or UVB irradiation.
Carcinogenesis 1992;13(11):2169-74.
1991: Henricus Sterenborg; Frank R de Gruijl; G Kelfkens; Jan C van der Leun
Evaluation of skin cancer risk resulting from long term occupational exposure to radiation from ultraviolet lasers in the range from 190 to 400 nm.
Photochemistry and photobiology 1991;54(5):775-80.
1991: Frank R de Gruijl; L Roza
Photoreactivation in humans.
Journal of photochemistry and photobiology. B, Biology 1991;10(4):367-71.
1991: G Kelfkens; Frank R de Gruijl; Jan C van der Leun
Tumorigenesis by short-wave ultraviolet A: papillomas versus squamous cell carcinomas.
Carcinogenesis 1991;12(8):1377-82.
1991: G Kelfkens; Huib van Weelden; Frank R de Gruijl; Jan C van der Leun
The influence of dose rate on ultraviolet tumorigenesis.
Journal of photochemistry and photobiology. B, Biology 1991;10(1-2):41-50.
1991: L Roza; Frank R de Gruijl; J B Bergen Henegouwen; K Guikers; Huib van Weelden; Govert P van der Schans; RA Baan
Detection of photorepair of UV-induced thymine dimers in human epidermis by immunofluorescence microscopy.
The Journal of investigative dermatology 1991;96(6):903-7.
1991: Arie A Vink; Rob J W Berg; Frank R de Gruijl; L Roza; RA Baan
Induction, repair and accumulation of thymine dimers in the skin of UV-B-irradiated hairless mice.
Carcinogenesis 1991;12(5):861-4.
1991: Frank R de Gruijl; Jan C van der Leun
Development of skin tumors in hairless mice after discontinuation of ultraviolet irradiation.
Cancer research 1991;51(3):979-84.
1990: G Kelfkens; Frank R de Gruijl; Jan C van der Leun
Ozone depletion and increase in annual carcinogenic ultraviolet dose.
Photochemistry and photobiology 1990;52(4):819-23.
1988: Huib van Weelden; Frank R de Gruijl; SC van der Putte; Johan Toonstra; Jan C van der Leun
The carcinogenic risks of modern tanning equipment: is UV-A safer than UV-B?
Archives of dermatological research 1988;280(5):300-7.
1986: Henricus Sterenborg; Frank R de Gruijl; Jan C van der Leun
UV-induced epidermal hyperplasia in hairless mice.
Photo-dermatology 1986;3(4):206-14.