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Hugo de Jonge

Research Profile

Chemicals & Drugs

Disorders

Cystic Fibrosis

Living Beings

Mouse
Rats

Anatomy

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TOP 3
Marcel J C Bijvelds; Hugo R de Jonge; Henkjan J Verkade
Bile acid handling in cystic fibrosis: marked phenotypic differences between mouse models.
Fang Xiao; Anurag Kumar Singh; Ayesha Sultan; Jiang Wang; Hugo R de Jonge; Georg Lamprecht; Min Goo Lee; Junhua Li; Henry Park; Brigitte Riederer; Bob J Scholte; Ursula Seidler
Rescue of epithelial HCO3- secretion in murine intestine by apical membrane expression of the cystic fibrosis transmembrane conductance regulator mutant F508del.
Frank A J A Bodewes; Hugo R de Jonge; Rick Havinga; Marcel J C Bijvelds; Marjan Wouthuyzen-Bakker; Henkjan J Verkade
Ursodeoxycholate modulates bile flow and bile salt pool independently from the cystic fibrosis transmembrane regulator (Cftr) in mice.

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All Publications

2012: Marcel J C Bijvelds; Hugo R de Jonge; Henkjan J Verkade
Bile acid handling in cystic fibrosis: marked phenotypic differences between mouse models.
Gastroenterology 2012;143(6):e19-20; author reply e20.
2012: Fang Xiao; Anurag Kumar Singh; Ayesha Sultan; Jiang Wang; Hugo R de Jonge; Georg Lamprecht; Min Goo Lee; Junhua Li; Henry Park; Brigitte Riederer; Bob J Scholte; Ursula Seidler
Rescue of epithelial HCO3- secretion in murine intestine by apical membrane expression of the cystic fibrosis transmembrane conductance regulator mutant F508del.
The Journal of physiology 2012;590(Pt 21):5317-34.
2012: Frank A J A Bodewes; Hugo R de Jonge; Rick Havinga; Marcel J C Bijvelds; Marjan Wouthuyzen-Bakker; Henkjan J Verkade
Ursodeoxycholate modulates bile flow and bile salt pool independently from the cystic fibrosis transmembrane regulator (Cftr) in mice.
American journal of physiology. Gastrointestinal and liver physiology 2012;302(9):G1035-42.
2012: Martina Wilke; Alice Bot; Huub Jorna; Bob J Scholte; Hugo R de Jonge
Rescue of murine F508del CFTR activity in native intestine by low temperature and proteasome inhibitors.
PloS one 2012;7(12):e52070.
2012: Marjan Wouthuyzen-Bakker; Marcel J C Bijvelds; Johannes G M Burgerhof; Hugo R de Jonge; Robert C De Lisle; Henkjan J Verkade
Effect of antibiotic treatment on fat absorption in mice with cystic fibrosis.
Pediatric research 2012;71(1):4-12.
2011: Rakhilya Murtazina; Ursula Seidler; Nicholas Constantine Zachos; Boris M Hogema; Hetal S Kocinsky; Olga Kovbasnjuk; Tian-E Chen; Yeuping Chen; Hugo R de Jonge; Mark Donowitz
NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum.
American journal of physiology. Cell physiology 2011;301(1):C126-36.
2011: Kris De Boeck; Hugo R de Jonge; N Derichs; I Fajac; M Hug; P Melotti; P G Middleton; I Sermet; D N Sheppard; F Vermeulen; M Wilschanski; I Bronsveld; Harry Cuppens
New clinical diagnostic procedures for cystic fibrosis in Europe.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2011;10 Suppl 2():S53-66.
2011: Martina Wilke; David N Sheppard; Lhousseine Touqui; Jamil Aarbiou; Alice G M Bot; Ruvalic M Buijs-Offerman; William H Colledge; Hugo R de Jonge; Huub Jorna; Bob J Scholte
Mouse models of cystic fibrosis: phenotypic analysis and research applications.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2011;10 Suppl 2():S152-71.
2011: RAFIQUEL SARKER; Vera E Valkhoff; Nicholas Constantine Zachos; Rong Lin; Boyoung Cha; Tian-e Chen; Sandra E Guggino; Mirza Zizak; Hugo R de Jonge; Boris M Hogema; Mark Donowitz
NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.
American journal of physiology. Cell physiology 2011;300(4):C771-82.
2011: Linda B C Bralten; Nanne K Kloosterhof; Rutger Balvers; Andrea Sacchetti; Lariesa Lapre; Martine Lamfers; Sieger Leenstra; Hugo R de Jonge; Johan M Kros; Erwin E W Jansen; Eduard A Struys; Cornelis Jakobs; Gajja S Salomons; Sander H Diks; Maikel Peppelenbosch; Andreas Kremer; Casper C Hoogenraad; Peter A E Sillevis Smitt; Pim J French
IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo.
Annals of neurology 2011;69(3):455-63.
2011: Rong Lin; Rakhilya Murtazina; Boyoung Cha; Molee Chakraborty; RAFIQUEL SARKER; Tian-E Chen; Zhihong Lin; Boris M Hogema; Hugo R de Jonge; Ursula Seidler; Jerrold R Turner; Xuhang Li; Olga Kovbasnjuk; Mark Donowitz
D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent process.
Gastroenterology 2011;140(2):560-71.
2009: Marcel J C Bijvelds; Alice G M Bot; Johanna C Escher; Hugo R de Jonge
Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator.
Gastroenterology 2009;137(3):976-85.
2009: Anurag Kumar Singh; Brigitte Riederer; Anja Krabbenhöft; Brigitte Rausch; Janina Bonhagen; Ulrich Lehmann; Hugo R de Jonge; Mark Donowitz; Chris Yun; Edward J Weinman; Olivier Kocher; Boris M Hogema; Ursula Seidler
Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice.
The Journal of clinical investigation 2009;119(3):540-50.
2009: N Broere; Mingmin Chen; A Cinar; A K Singh; Jutta Hillesheim; Brigitte Riederer; M Lünnemann; I Rottinghaus; A Krabbenhöft; Regina Engelhardt; B Rausch; Edward J Weinman; Mark Donowitz; Ann L Hubbard; O Kocher; Hugo R de Jonge; Boris M Hogema; Ursula Seidler
Defective jejunal and colonic salt absorption and alteredNa(+)/H (+) exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice.
Pflügers Archiv : European journal of physiology 2009;457(5):1079-91.
2008: Rochelle Cunningham; Ali Esmaili; Eric Brown; Rajatsubhra Biswas; Rakhilya Murtazina; Mark Donowitz; Henry B Dijkman; Johan Van der Vlag; Boris M Hogema; Hugo R de Jonge; Shirish Shenolikar; James B Wade; Edward J Weinman
Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice.
American journal of physiology. Renal physiology 2008;294(4):F1001-7.
2008: bob arthur lubamba; Hugues Lecourt; Jean Lebacq; Patrick LEBECQUE; Hugo R de Jonge; Pierre Wallemacq; Teresinha Leal
Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis.
American journal of respiratory and critical care medicine 2008;177(5):506-15.
2008: Balázs Tóth; Martina Wilke; Frauke Stanke; Martina Dorsch; Silke Jansen; Dirk Wedekind; Nikoletta Charizopoulou; Alice Bot; Marion Burmester; Sabine Leonhard-Marek; Hugo R de Jonge; Hans J Hedrich; Gerhard Breves; Burkhard Tümmler
Very mild disease phenotype of congenic CftrTgH(neoim)Hgu cystic fibrosis mice.
BMC genetics 2008;9():28.
2007: Nellie Broere; Jutta Hillesheim; Bi-Guang Tuo; Huub Jorna; Adriaan B Houtsmuller; Shirish Shenolikar; Edward J Weinman; Mark Donowitz; Ursula Seidler; Hugo R de Jonge; Boris M Hogema
Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice.
The Journal of biological chemistry 2007;282(52):37575-84.
2007: Rakhilya Murtazina; Olga Kovbasnjuk; Nicholas Constantine Zachos; Xuhang Li; Yueping Chen; Ann L Hubbard; Boris M Hogema; Deborah Steplock; Ursula Seidler; Mirajul Kazi; Chung-Ming Tse; Hugo R de Jonge; Edward J Weinman; Mark Donowitz
Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule.
The Journal of biological chemistry 2007;282(34):25141-51.
2007: Hugo R de Jonge
Cystic fibrosis mice rehabilitated for studies of airway gland dysfunction.
The Journal of physiology 2007;580(Pt 1):7-8.
2007: Henry M Staines; Abdulnaser Alkhalil; Richard J Allen; Hugo R de Jonge; Elvira Derbyshire; Stéphane Egée; Hagai Ginsburg; David A Hill; Stephan M Huber; Kiaran Kirk; Florian Lang; Godfrey Lisk; Eugene Oteng; Ajay D Pillai; Kempaiah Rayavara; Sherin Rouhani; Kevin Saliba; Crystal Shen; Tsione Solomon; Serge L Y Thomas; Patrick Verloo; Sanjay A Desai
Electrophysiological studies of malaria parasite-infected erythrocytes: current status.
International journal for parasitology 2007;37(5):475-82.
2007: François Jouret; Alfred Bernard; Cédric Hermans; Geneviève Dom; Sara Terryn; Teresinha Leal; Patrick LEBECQUE; Jean-Jacques Cassiman; Bob J Scholte; Hugo R de Jonge; Pierre J Courtoy; Olivier Devuyst
Cystic fibrosis is associated with a defect in apical receptor-mediated endocytosis in mouse and human kidney.
Journal of the American Society of Nephrology : JASN 2007;18(3):707-18.
2007: Christina H Lim; Alice G M Bot; Hugo R de Jonge; Ben C Tilly
Osmosignaling and volume regulation in intestinal epithelial cells.
Methods in enzymology 2007;428():325-42.
2007: Christina H Lim; Marcel J C Bijvelds; Alex L Nigg; Kees Schoonderwoerd; Adriaan B Houtsmuller; Hugo R de Jonge; Ben C Tilly
Cholesterol depletion and genistein as tools to promote F508delCFTR retention at the plasma membrane.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;20(5):473-82.
2006: Christina H Lim; Kees Schoonderwoerd; W J Kleijer; Hugo R de Jonge; Ben C Tilly
Regulation of the cell swelling-activated chloride conductance by cholesterol-rich membrane domains.
Acta physiologica (Oxford, England) 2006;187(1-2):295-303.
2006: Nikoletta Charizopoulou; Martina Wilke; Martina Dorsch; Alice Bot; Huub Jorna; Silke Jansen; Frauke Stanke; Hans J Hedrich; Hugo R de Jonge; Burkhard Tümmler
Spontaneous rescue from cystic fibrosis in a mouse model.
BMC genetics 2006;7():18.
2005: Marcel J C Bijvelds; Huub Jorna; Henkjan J Verkade; Alice G M Bot; Franz Hofmann; Luis B Agellon; Maarten Sinaasappel; Hugo R de Jonge
Activation of CFTR by ASBT-mediated bile salt absorption.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(5):G870-9.
2005: Bertrand Kleizen; Thijs van Vlijmen; Hugo R de Jonge; Ineke Braakman
Folding of CFTR is predominantly cotranslational.
Molecular cell 2005;20(2):277-87.
2005: Boyoung Cha; Jae Ho Kim; Hans Hut; Boris M Hogema; Janani Nadarja; Mirza Zizak; Megan Cavet; Whaseon L Kwon; Suzanne M Lohmann; Albert Smolenski; Chung-Ming Tse; Chris Yun; Hugo R de Jonge; Mark Donowitz
cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein.
The Journal of biological chemistry 2005;280(17):16642-50.
2005: Marcel J C Bijvelds; Inez Bronsveld; Rick Havinga; Maarten Sinaasappel; Hugo R de Jonge; Henkjan J Verkade
Fat absorption in cystic fibrosis mice is impeded by defective lipolysis and post-lipolytic events.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(4):G646-53.
2005: Arie B Vaandrager; Boris M Hogema; Hugo R de Jonge
Molecular properties and biological functions of cGMP-dependent protein kinase II.
Frontiers in bioscience : a journal and virtual library 2005;10():2150-64.
2004: Anniek Werner; Marloes E J Bongers; Marcel J C Bijvelds; Hugo R de Jonge; Henkjan J Verkade
No indications for altered essential fatty acid metabolism in two murine models for cystic fibrosis.
Journal of lipid research 2004;45(12):2277-86.
2004: Lara R Gawenis; Hans Hut; Alice G M Bot; Gary E Shull; Hugo R de Jonge; Xavier Stien; Marian L Miller; Lane L Clarke
Electroneutral sodium absorption and electrogenic anion secretion across murine small intestine are regulated in parallel.
American journal of physiology. Gastrointestinal and liver physiology 2004;287(6):G1140-9.
2004: Bob J Scholte; Donald J Davidson; Martina Wilke; Hugo R de Jonge
Animal models of cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2004;3 Suppl 2():183-90.
2004: Hugo R de Jonge; Manfred Ballmann; Henk J Veeze; Inez Bronsveld; Frauke Stanke; Burkhard Tümmler; Maarten Sinaasappel
Ex vivo CF diagnosis by intestinal current measurements (ICM) in small aperture, circulating Ussing chambers.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2004;3 Suppl 2():159-63.
2004: Filipa Mendes; Carlos M Farinha; Mónica Roxo Rosa; Pascale Fanen; Aleksander Edelman; Robert L Dormer; Margaret McPherson; Heather Davidson; Edith Puchelle; Hugo R de Jonge; Ghanshyam D Heda; Martina Gentzsch; Gergely L Lukacs; Deborah Penque; Margarida D Amaral
Antibodies for CFTR studies.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2004;3 Suppl 2():69-72.
2004: Filipa Mendes; Laurent Doucet; Alexandre Hinzpeter; Claude Férec; Joanna Lipecka; Janine Fritsch; Aleksander Edelman; Huub Jorna; Rob Willemsen; Alice G M Bot; Hugo R de Jonge; Jocelyne Hinnrasky; Nicolas Castillon; Karima Taouil; Edith Puchelle; Deborah Penque; Margarida D Amaral
Immunohistochemistry of CFTR in native tissues and primary epithelial cell cultures.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2004;3 Suppl 2():37-41.
2004: Sebastian F B Tomassen; Durk Fekkes; Hugo R de Jonge; Ben C Tilly
Osmotic swelling-provoked release of organic osmolytes in human intestinal epithelial cells.
American journal of physiology. Cell physiology 2004;286(6):C1417-22.
2004: Sebastian F B Tomassen; Thea van der Wijk; Hugo R de Jonge; Ben C Tilly
Activation of phospholipase D by osmotic cell swelling.
FEBS letters 2004;566(1-3):287-90.
2004: Patrick Verloo; Clemens H M Kocken; Annemarie van der Wel; Ben C Tilly; Boris M Hogema; Maarten Sinaasappel; Alan Thomas; Hugo R de Jonge
Plasmodium falciparum-activated chloride channels are defective in erythrocytes from cystic fibrosis patients.
The Journal of biological chemistry 2004;279(11):10316-22.
2004: Sebastian Tomassen; Hugo R de Jonge; Ben C Tilly
Cell volume regulation in intestinal epithelial cells.
Advances in experimental medicine and biology 2004;559():339-47.
2003: Robert Feil; Suzanne M Lohmann; Hugo R de Jonge; Ulrich Walter; Franz Hofmann
Cyclic GMP-dependent protein kinases and the cardiovascular system: insights from genetically modified mice.
Circulation research 2003;93(10):907-16.
2003: Thea van der Wijk; Sebastian F B Tomassen; Adriaan B Houtsmuller; Hugo R de Jonge; Ben C Tilly
Increased vesicle recycling in response to osmotic cell swelling. Cause and consequence of hypotonicity-provoked ATP release.
The Journal of biological chemistry 2003;278(41):40020-5.
2003: Arie B Vaandrager; Boris M Hogema; Marcel Edixhoven; Caroline M M van den Burg; Alice G M Bot; Peter Klatt; Peter Ruth; Franz Hofmann; Jozef Van Damme; Joel Vandekerckhove; Hugo R de Jonge
Autophosphorylation of cGMP-dependent protein kinase type II.
The Journal of biological chemistry 2003;278(31):28651-8.
2001: Inez Bronsveld; Frauke Mekus; Jan Bijman; Manfred Ballmann; Hugo R de Jonge; Ulrike Laabs; D J J Halley; H Ellemunter; G Mastella; S Thomas; Henk J Veeze; Burkhard Tümmler
Chloride conductance and genetic background modulate the cystic fibrosis phenotype of Delta F508 homozygous twins and siblings.
The Journal of clinical investigation 2001;108(11):1705-15.
2000: Hugo R de Jonge; Boris M Hogema; Ben C Tilly
Protein N-myristoylation: critical role in apoptosis and salt tolerance.
Science's STKE : signal transduction knowledge environment 2000;2000(63):pe1.
2000: Bertrand Kleizen; Ineke Braakman; Hugo R de Jonge
Regulated trafficking of the CFTR chloride channel.
European journal of cell biology 2000;79(8):544-56.
2000: Inez Bronsveld; Frauke Mekus; Jan Bijman; Manfred Ballmann; J Greipel; J Hundrieser; D J J Halley; Ulrike Laabs; R Busche; Hugo R de Jonge; Burkhard Tümmler; Henk J Veeze
Residual chloride secretion in intestinal tissue of deltaF508 homozygous twins and siblings with cystic fibrosis. The European CF Twin and Sibling Study Consortium.
Gastroenterology 2000;119(1):32-40.
2000: Thea van der Wijk; Sebastian F B Tomassen; Hugo R de Jonge; Ben C Tilly
Signalling mechanisms involved in volume regulation of intestinal epithelial cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2000;10(5-6):289-96.
2000: Arie B Vaandrager; Alice G M Bot; Peter Ruth; A Pfeifer; Franz Hofmann; Hugo R de Jonge
Differential role of cyclic GMP-dependent protein kinase II in ion transport in murine small intestine and colon.
Gastroenterology 2000;118(1):108-14.
1999: Thea van der Wijk; Hugo R de Jonge; Ben C Tilly
Osmotic cell swelling-induced ATP release mediates the activation of extracellular signal-regulated protein kinase (Erk)-1/2 but not the activation of osmo-sensitive anion channels.
The Biochemical journal 1999;343 Pt 3():579-86.
1999: Joost G J Hoenderop; Arie B Vaandrager; Lisette Dijkink; Albert Smolenski; Stepan Gambaryan; Suzanne M Lohmann; Hugo R de Jonge; Peter H G M Willems; René J M Bindels
Atrial natriuretic peptide-stimulated Ca2+ reabsorption in rabbit kidney requires membrane-targeted, cGMP-dependent protein kinase type II.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6084-9.
1999: Carl F Verkoelen; dirk kok; Burt G van der Boom; Hugo R de Jonge; Fritz H Schröder; Johannes C Romijn
LLC-PK1 cells as a model system to study proximal tubule transport of water and other compounds relevant for renal stone disease.
Urological research 1999;27(2):109-15.
1998: Thea van der Wijk; J Dorrestijn; S Narumiya; J Antonie Maassen; Hugo R de Jonge; Ben C Tilly
Osmotic swelling-induced activation of the extracellular-signal-regulated protein kinases Erk-1 and Erk-2 in intestine 407 cells involves the Ras/Raf-signalling pathway.
The Biochemical journal 1998;331 ( Pt 3)():863-9.
1998: Arie B Vaandrager; Albert Smolenski; Ben C Tilly; Adriaan B Houtsmuller; E M Ehlert; Alice G M Bot; Marcel Edixhoven; W E Boomaars; Suzanne M Lohmann; Hugo R de Jonge
Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl- channel activation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1466-71.
1997: Pim J French; Jan Bijman; Alice G M Bot; W E Boomaars; Bob J Scholte; Hugo R de Jonge
Genistein activates CFTR Cl- channels via a tyrosine kinase- and protein phosphatase-independent mechanism.
The American journal of physiology 1997;273(2 Pt 1):C747-53.
1997: Suzanne M Lohmann; Arie B Vaandrager; Albert Smolenski; Ulrich Walter; Hugo R de Jonge
Distinct and specific functions of cGMP-dependent protein kinases.
Trends in biochemical sciences 1997;22(8):307-12.
1997: Arie B Vaandrager; Marcel Edixhoven; Alice G M Bot; Marian A Kroos; Thomas Jarchau; Suzanne M Lohmann; Hans-Gottfried Genieser; Hugo R de Jonge
Endogenous type II cGMP-dependent protein kinase exists as a dimer in membranes and can Be functionally distinguished from the type I isoforms.
The Journal of biological chemistry 1997;272(18):11816-23.
1997: Arie B Vaandrager; Ben C Tilly; Albert Smolenski; S Schneider-Rasp; Alice G M Bot; Marcel Edixhoven; Bob J Scholte; Thomas Jarchau; Ulrich Walter; Suzanne M Lohmann; Wolfgang Poller; Hugo R de Jonge
cGMP stimulation of cystic fibrosis transmembrane conductance regulator Cl- channels co-expressed with cGMP-dependent protein kinase type II but not type Ibeta.
The Journal of biological chemistry 1997;272(7):4195-200.
1997: Arie B Vaandrager; Alice G M Bot; Hugo R de Jonge
Guanosine 3',5'-cyclic monophosphate-dependent protein kinase II mediates heat-stable enterotoxin-provoked chloride secretion in rat intestine.
Gastroenterology 1997;112(2):437-43.
1996: Ben C Tilly; M Gaestel; K Engel; Marcel Edixhoven; Hugo R de Jonge
Hypo-osmotic cell swelling activates the p38 MAP kinase signalling cascade.
FEBS letters 1996;395(2-3):133-6.
1996: T M Teune; A J Timmers-Reker; Jan Bouquet; J Bijman; Hugo R de Jonge; Maarten Sinaasappel
In vivo measurement of chloride and water secretion in the jejunum of cystic fibrosis patients.
Pediatric research 1996;40(4):522-7.
1996: P J French; J Hikke van Doorninck; R H Peters; E Verbeek; N A Ameen; C R Marino; Hugo R de Jonge; Jan Bijman; Bob J Scholte
A delta F508 mutation in mouse cystic fibrosis transmembrane conductance regulator results in a temperature-sensitive processing defect in vivo.
The Journal of clinical investigation 1996;98(6):1304-12.
1996: Ben C Tilly; Marcel Edixhoven; Leon Tertoolen; N Morii; Y Saitoh; S Narumiya; Hugo R de Jonge
Activation of the osmo-sensitive chloride conductance involves P21rho and is accompanied by a transient reorganization of the F-actin cytoskeleton.
Molecular biology of the cell 1996;7(9):1419-27.
1996: Ben C Tilly; Karel Bezstarosti; W E Boomaars; C R Marino; Jos M J Lamers; Hugo R de Jonge
Expression and regulation of chloride channels in neonatal rat cardiomyocytes.
Molecular and cellular biochemistry 1996;157(1-2):129-35.
1996: Arie B Vaandrager; Hugo R de Jonge
Signalling by cGMP-dependent protein kinases.
Molecular and cellular biochemistry 1996;157(1-2):23-30.
1996: Arie B Vaandrager; E M Ehlert; Thomas Jarchau; Suzanne M Lohmann; Hugo R de Jonge
N-terminal myristoylation is required for membrane localization of cGMP-dependent protein kinase type II.
The Journal of biological chemistry 1996;271(12):7025-9.
1996: Keith T Wilson; Arie B Vaandrager; J De Vente; Mark W Musch; Hugo R de Jonge; Eugene B Chang
Production and localization of cGMP and PGE2 in nitroprusside-stimulated rat colonic ion transport.
The American journal of physiology 1996;270(3 Pt 1):C832-40.
1995: Cynthia L Sears; F Firoozmand; A Mellander; F G Chambers; I G Eromar; Alice G M Bot; Bob J Scholte; Hugo R de Jonge; Mark Donowitz
Genistein and tyrphostin 47 stimulate CFTR-mediated Cl- secretion in T84 cell monolayers.
The American journal of physiology 1995;269(6 Pt 1):G874-82.
1995: P J French; Jan Bijman; Marcel Edixhoven; Arie B Vaandrager; Bob J Scholte; Suzanne M Lohmann; Angus Nairn; Hugo R de Jonge
Isotype-specific activation of cystic fibrosis transmembrane conductance regulator-chloride channels by cGMP-dependent protein kinase II.
The Journal of biological chemistry 1995;270(44):26626-31.
1995: R Draijer; Arie B Vaandrager; C Nolte; Hugo R de Jonge; U Walter; V W van Hinsbergh
Expression of cGMP-dependent protein kinase I and phosphorylation of its substrate, vasodilator-stimulated phosphoprotein, in human endothelial cells of different origin.
Circulation research 1995;77(5):897-905.
1995: R B Bajnath; K Dekker; Hugo R de Jonge; Jack A Groot
Chloride secretion induced by phorbol dibutyrate and forskolin in the human colonic carcinoma cell line HT-29Cl.19A is regulated by different mechanisms.
Pflügers Archiv : European journal of physiology 1995;430(5):705-12.
1995: T Markert; Arie B Vaandrager; Stepan Gambaryan; D Pöhler; C Häusler; Ulrich Walter; Hugo R de Jonge; Thomas Jarchau; Suzanne M Lohmann
Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator.
The Journal of clinical investigation 1995;96(2):822-30.
1995: S I Abrahamse; Hugo R de Jonge; René J M Bindels; Carel H van Os
Two distinct K(+)-ATPase activities in rabbit distal colon.
Biochemical and biophysical research communications 1995;207(3):1003-8.
1994: Ben C Tilly; Marcel Edixhoven; N van den Berghe; Alice G M Bot; Hugo R de Jonge
Ca(2+)-mobilizing hormones potentiate hypotonicity-induced activation of ionic conductances in Intestine 407 cells.
The American journal of physiology 1994;267(5 Pt 1):C1271-8.
1994: Thomas Jarchau; C Häusler; T Markert; D Pöhler; J Vanderkerckhove; Hugo R de Jonge; Suzanne M Lohmann; Ulrich Walter
Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9426-30.
1994: Arie B Vaandrager; E van der Wiel; M L Hom; L H Luthjens; Hugo R de Jonge
Heat-stable enterotoxin receptor/guanylyl cyclase C is an oligomer consisting of functionally distinct subunits, which are non-covalently linked in the intestine.
The Journal of biological chemistry 1994;269(23):16409-15.
1994: Henk J Veeze; D J J Halley; Jan Bijman; Johan C de Jongste; Hugo R de Jonge; Maarten Sinaasappel
Determinants of mild clinical symptoms in cystic fibrosis patients. Residual chloride secretion measured in rectal biopsies in relation to the genotype.
The Journal of clinical investigation 1994;93(2):461-6.
1994: Arie B Vaandrager; Hugo R de Jonge
Effect of cyclic GMP on intestinal transport.
Advances in pharmacology (San Diego, Calif.) 1994;26():253-83.
1993: R B Bajnath; N van den Berghe; Hugo R de Jonge; Jack A Groot
Activation of ion transport by combined effects of ionomycin, forskolin and phorbol ester on cultured HT-29cl.19A human colonocytes.
Pflügers Archiv : European journal of physiology 1993;425(1-2):90-9.
1993: R B Bajnath; Jack A Groot; Hugo R de Jonge; M Kansen; Jan Bijman
Synergistic activation of non-rectifying small-conductance chloride channels by forskolin and phorbol esters in cell-attached patches of the human colon carcinoma cell line HT-29cl.19A.
Pflügers Archiv : European journal of physiology 1993;425(1-2):100-8.
1993: Ben C Tilly; N van den Berghe; Leon Tertoolen; Marcel Edixhoven; Hugo R de Jonge
Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances.
The Journal of biological chemistry 1993;268(27):19919-22.
1993: Arie B Vaandrager; E van der Wiel; Hugo R de Jonge
Heat-stable enterotoxin activation of immunopurified guanylyl cyclase C. Modulation by adenine nucleotides.
The Journal of biological chemistry 1993;268(26):19598-603.
1993: R B Bajnath; Jack A Groot; Hugo R de Jonge; M Kansen; Jan Bijman
Calcium ionophore plus excision induce a large conductance chloride channel in membrane patches of human colon carcinoma cells HT-29cl.19A.
Experientia 1993;49(4):313-6.
1993: M Kansen; R B Bajnath; Jack A Groot; Hugo R de Jonge; Bob J Scholte; André Hoogeveen; Jan Bijman
Regulation of chloride channels in the human colon carcinoma cell line HT29.cl19A.
Pflügers Archiv : European journal of physiology 1993;422(6):539-45.
1993: Roel Bakker; K Dekker; Hugo R de Jonge; Jack A Groot
VIP, serotonin, and epinephrine modulate the ion selectivity of tight junctions of goldfish intestine.
The American journal of physiology 1993;264(2 Pt 2):R362-8.
1993: Arie B Vaandrager; S Schulz; Hugo R de Jonge; David L Garbers
Guanylyl cyclase C is an N-linked glycoprotein receptor that accounts for multiple heat-stable enterotoxin-binding proteins in the intestine.
The Journal of biological chemistry 1993;268(3):2174-9.
1992: R B Bajnath; M H van Hoeve; Hugo R de Jonge; Jack A Groot
Regulation of apical Cl- conductance and basolateral K+ conductances by phorbol esters in HT-29cl.19A cells.
The American journal of physiology 1992;263(4 Pt 1):C759-66.
1992: Ben C Tilly; Grazia M S Mancini; Jan Bijman; Pieter van Gageldonk; Cecile E M T Beerens; R J Bridges; Hugo R de Jonge; Frans W Verheijen
Nucleotide-activated chloride channels in lysosomal membranes.
Biochemical and biophysical research communications 1992;187(1):254-60.
1992: N van den Berghe; Arie B Vaandrager; Alice G M Bot; P J Parker; Hugo R de Jonge
Dual role for protein kinase C alpha as a regulator of ion secretion in the HT29cl.19A human colonic cell line.
The Biochemical journal 1992;285 ( Pt 2)():673-9.
1992: M Kansen; J L M Keulemans; André Hoogeveen; Bob J Scholte; Arie B Vaandrager; A W van der Kamp; Maarten Sinaasappel; Alice G M Bot; Hugo R de Jonge; Jan Bijman
Regulation of chloride transport in cultured normal and cystic fibrosis keratinocytes.
Biochimica et biophysica acta 1992;1139(1-2):49-56.
1992: R B Bajnath; K Dekker; Arie B Vaandrager; Hugo R de Jonge; Jack A Groot
Biphasic increase of apical Cl- conductance by muscarinic stimulation of HT-29cl.19A human colon carcinoma cell line: evidence for activation of different Cl- conductances by carbachol and forskolin.
The Journal of membrane biology 1992;127(2):81-94.
1992: Arie B Vaandrager; Alice G M Bot; J De Vente; Hugo R de Jonge
Atriopeptins and Escherichia coli enterotoxin STa have different sites of action in mammalian intestine.
Gastroenterology 1992;102(4 Pt 1):1161-9.
1992: Arie B Vaandrager; N van den Berghe; Alice G M Bot; Hugo R de Jonge
Phorbol esters stimulate and inhibit Cl- secretion by different mechanisms in a colonic cell line.
The American journal of physiology 1992;262(2 Pt 1):G249-56.
1991: Arie B Vaandrager; R Bajnath; Jack A Groot; Alice G M Bot; Hugo R de Jonge
Ca2+ and cAMP activate different chloride efflux pathways in HT-29.cl19A colonic epithelial cell line.
The American journal of physiology 1991;261(6 Pt 1):G958-65.
1991: N van den Berghe; N J Nieuwkoop; Arie B Vaandrager; Hugo R de Jonge
Asymmetrical distribution of G-proteins among the apical and basolateral membranes of rat enterocytes.
The Biochemical journal 1991;278 ( Pt 2)():565-71.
1991: Henk J Veeze; Maarten Sinaasappel; J Bijman; Jan Bouquet; Hugo R de Jonge
Ion transport abnormalities in rectal suction biopsies from children with cystic fibrosis.
Gastroenterology 1991;101(2):398-403.
1991: R B Bajnath; C Augeron; Christian L Laboisse; Jan Bijman; Hugo R de Jonge; Jack A Groot
Electrophysiological studies of forskolin-induced changes in ion transport in the human colon carcinoma cell line HT-29 cl.19A: lack of evidence for a cAMP-activated basolateral K+ conductance.
The Journal of membrane biology 1991;122(3):239-50.
1991: André Hoogeveen; J L M Keulemans; Rob Willemsen; Bob J Scholte; Jan Bijman; Marcel Edixhoven; Hugo R de Jonge; H Galjaard
Immunological localization of cystic fibrosis candidate gene products.
Experimental cell research 1991;193(2):435-7.
1991: Ben C Tilly; M Kansen; Pieter van Gageldonk; N van den Berghe; H Galjaard; Jan Bijman; Hugo R de Jonge
G-proteins mediate intestinal chloride channel activation.
The Journal of biological chemistry 1991;266(4):2036-40.
1991: Alexander P J Houdijk; M J Adolfs; Paul A M van Leeuwen; I L Bonta; Hugo R de Jonge
Cyclic nucleotides in human macrophages: effects of atrial natriuretic factor and nitroprusside on cGMP and cAMP production.
International journal of tissue reactions 1991;13(6):287-93.
1990: Arie B Vaandrager; M C Ploemacher; Hugo R de Jonge
Phosphoinositide metabolism in intestinal brush borders: stimulation of IP3 formation by guanine nucleotides and Ca2+.
The American journal of physiology 1990;259(3 Pt 1):G410-9.
1990: D J J Halley; J Bijman; Hugo R de Jonge; Maarten Sinaasappel; Herman J Neijens; Martinus F Niermeijer
The cystic fibrosis defect approached from different angles--new perspectives on the gene, the chloride channel, diagnosis and therapy.
European journal of pediatrics 1990;149(10):670-7.
1990: Alexander P J Houdijk; M J Adolfs; I L Bonta; Hugo R de Jonge
Atriopeptins and nitroprusside provoke opposite changes in cGMP and cAMP levels in human macrophages.
European journal of pharmacology 1990;179(3):413-7.
1990: E Verbeek; Hugo R de Jonge; Jan Bijman; J L M Keulemans; Maarten Sinaasappel; A W van der Kamp; Bob J Scholte
Chloride transport in cultured nasal epithelium of cystic fibrosis patients.
Pflügers Archiv : European journal of physiology 1990;415(5):540-6.
1990: Ben C Tilly; M Kansen; Pieter van Gageldonk; N van den Berghe; Jan Bijman; Hugo R de Jonge
Activation of intestinal chloride channels by GTP-binding regulatory proteins.
Advances in second messenger and phosphoprotein research 1990;24():95-100.
1989: Hugo R de Jonge; N van den Berghe; Ben C Tilly; M Kansen; Jan Bijman
(Dys)regulation of epithelial chloride channels.
Biochemical Society transactions 1989;17(5):816-8.
1989: Grazia M S Mancini; Hugo R de Jonge; H Galjaard; Frans W Verheijen
Characterization of a proton-driven carrier for sialic acid in the lysosomal membrane. Evidence for a group-specific transport system for acidic monosaccharides.
The Journal of biological chemistry 1989;264(26):15247-54.
1988: Arie B Vaandrager; Hugo R de Jonge
A sensitive technique for the determination of anion exchange activities in brush-border membrane vesicles. Evidence for two exchangers with different affinities for HCO3- and SITS in rat intestinal epithelium.
Biochimica et biophysica acta 1988;939(2):305-14.
1986: Arie B Vaandrager; M C Ploemacher; Hugo R de Jonge
Modulation of salt permeabilities of intestinal brush-border membrane vesicles by micromolar levels of internal calcium.
Biochimica et biophysica acta 1986;856(2):325-36.