Fernando de la Cruz

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Valverde Aránzazu; Cantón Rafael; Garcillán-Barcia M Pilar; Novais Angela; Galán Juan Carlos; Alvarado Andrés; de la Cruz Fernando; Baquero Fernando; Coque Teresa M
Spread of bla(CTX-M-14) is driven mainly by IncK plasmids disseminated among Escherichia coli phylogroups A, B1, and D in Spain.
Mihajlovic Sanja; Lang Silvia; Sut Marta V; Strohmaier Heimo; Gruber Christian J; Koraimann Günther; Cabezón Elena; Moncalián Gabriel; de la Cruz Fernando; Zechner Ellen L
Plasmid r1 conjugative DNA processing is regulated at the coupling protein interface.
Garcillán-Barcia María Pilar; Francia María Victoria; de la Cruz Fernando
The diversity of conjugative relaxases and its application in plasmid classification.

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2009: Valverde Aránzazu; Cantón Rafael; Garcillán-Barcia M Pilar; Novais Angela; Galán Juan Carlos; Alvarado Andrés; de la Cruz Fernando; Baquero Fernando; Coque Teresa M
Spread of bla(CTX-M-14) is driven mainly by IncK plasmids disseminated among Escherichia coli phylogroups A, B1, and D in Spain.
Antimicrobial agents and chemotherapy 2009;53(12):5204-12.
2009: Mihajlovic Sanja; Lang Silvia; Sut Marta V; Strohmaier Heimo; Gruber Christian J; Koraimann Günther; Cabezón Elena; Moncalián Gabriel; de la Cruz Fernando; Zechner Ellen L
Plasmid r1 conjugative DNA processing is regulated at the coupling protein interface.
Journal of bacteriology 2009;191(22):6877-87.
2009: Garcillán-Barcia María Pilar; Francia María Victoria; de la Cruz Fernando
The diversity of conjugative relaxases and its application in plasmid classification.
FEMS microbiology reviews 2009;33(3):657-87.
2009: González-Pérez Blanca; Carballeira José Daniel; Moncalián Gabriel; de la Cruz Fernando
Changing the recognition site of a conjugative relaxase by rational design.
Biotechnology journal 2009;4(4):554-7.
2009: Varsaki Athanasia; Moncalián Gabriel; Garcillán-Barcia Maria del Pilar; Drainas Constantin; de la Cruz Fernando
Analysis of ColE1 MbeC unveils an extended ribbon-helix-helix family of nicking accessory proteins.
Journal of bacteriology 2009;191(5):1446-55.
2009: Pérez-Mendoza Daniel; de la Cruz Fernando
Escherichia coli genes affecting recipient ability in plasmid conjugation: are there any?
BMC genomics 2009;10():71.
2008: Arechaga Ignacio; Peña Alejandro; Zunzunegui Sandra; del Carmen Fernández-Alonso María; Rivas Germán; de la Cruz Fernando
ATPase activity and oligomeric state of TrwK, the VirB4 homologue of the plasmid R388 type IV secretion system.
Journal of bacteriology 2008;190(15):5472-9.
2008: Garcillán-Barcia M Pilar; de la Cruz Fernando
Why is entry exclusion an essential feature of conjugative plasmids?
Plasmid 2008;60(1):1-18.
2008: Revilla Carlos; Garcillán-Barcia M Pilar; Fernández-López Raúl; Thomson Nicholas R; Sanders Mandy; Cheung Martin; Thomas Christopher M; de la Cruz Fernando
Different pathways to acquiring resistance genes illustrated by the recent evolution of IncW plasmids.
Antimicrobial agents and chemotherapy 2008;52(4):1472-80.
2007: Gonzalez-Perez Blanca; Lucas María; Cooke Leonie A; Vyle Joseph S; de la Cruz Fernando; Moncalián Gabriel
Analysis of DNA processing reactions in bacterial conjugation by using suicide oligonucleotides.
The EMBO journal 2007;26(16):3847-57.
2007: Tato Irantzu; Matilla Inmaculada; Arechaga Ignacio; Zunzunegui Sandra; de la Cruz Fernando; Cabezon Elena
The ATPase activity of the DNA transporter TrwB is modulated by protein TrwA: implications for a common assembly mechanism of DNA translocating motors.
The Journal of biological chemistry 2007;282(35):25569-76.
2007: Sánchez-Magraner Lissete; Viguera Ana R; García-Pacios Marcos; Garcillán M Pilar; Arrondo José-Luis R; de la Cruz Fernando; Goñi Félix M; Ostolaza Helena
The calcium-binding C-terminal domain of Escherichia coli alpha-hemolysin is a major determinant in the surface-active properties of the protein.
The Journal of biological chemistry 2007;282(16):11827-35.
2007: Garcillán-Barcia M Pilar; Jurado Paola; González-Pérez Blanca; Moncalián Gabriel; Fernández Luis A; de la Cruz Fernando
Conjugative transfer can be inhibited by blocking relaxase activity within recipient cells with intrabodies.
Molecular microbiology 2007;63(2):404-16.
2006: César Carolina Elvira; Machón Cristina; de la Cruz Fernando; Llosa Matxalen
A new domain of conjugative relaxase TrwC responsible for efficient oriT-specific recombination on minimal target sequences.
Molecular microbiology 2006;62(4):984-96.
2006: Fernández-López Raúl; Garcillán-Barcia M Pilar; Revilla Carlos; Lázaro Miguel; Vielva Luis; de la Cruz Fernando
Dynamics of the IncW genetic backbone imply general trends in conjugative plasmid evolution.
FEMS microbiology reviews 2006;30(6):942-66.
2006: Hormaeche Itsaso; Segura Rosa L; Vecino Ana J; Goñi Félix M; de la Cruz Fernando; Alkorta Itziar
The transmembrane domain provides nucleotide binding specificity to the bacterial conjugation protein TrwB.
FEBS letters 2006;580(13):3075-82.
2006: Boer Roeland; Russi Silvia; Guasch Alicia; Lucas María; Blanco Alexandre G; Pérez-Luque Rosa; Coll Miquel; de la Cruz Fernando
Unveiling the molecular mechanism of a conjugative relaxase: The structure of TrwC complexed with a 27-mer DNA comprising the recognition hairpin and the cleavage site.
Journal of molecular biology 2006;358(3):857-69.
2006: Cabezon Elena; de la Cruz Fernando
TrwB: an F(1)-ATPase-like molecular motor involved in DNA transport during bacterial conjugation.
Research in microbiology 2006;157(4):299-305.
2005: Fernandez-Lopez Raul; Machón Cristina; Longshaw Christopher M; Martin Steve; Molin Soren; Zechner Ellen L; Espinosa Manuel; Lanka Erich; de la Cruz Fernando
Unsaturated fatty acids are inhibitors of bacterial conjugation.
Microbiology (Reading, England) 2005;151(Pt 11):3517-26.
2005: de Paz Héctor D; Sangari Félix J; Bolland Silvia; García-Lobo Juan M; Dehio Christoph; de la Cruz Fernando; Llosa Matxalen
Functional interactions between type IV secretion systems involved in DNA transfer and virulence.
Microbiology (Reading, England) 2005;151(Pt 11):3505-16.
2005: Draper Olga; César Carolina Elvira; Machón Cristina; de la Cruz Fernando; Llosa Matxalen
Site-specific recombinase and integrase activities of a conjugative relaxase in recipient cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(45):16385-90.
2005: Tato I; Zunzunegui S; de la Cruz F; Cabezon E
TrwB, the coupling protein involved in DNA transport during bacterial conjugation, is a DNA-dependent ATPase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(23):8156-61.
2005: Llosa Matxalen; de la Cruz Fernando
Bacterial conjugation: a potential tool for genomic engineering.
Research in microbiology 2005;156(1):1-6.
2004: Moncalián Gabriel; de la Cruz Fernando
DNA binding properties of protein TrwA, a possible structural variant of the Arc repressor superfamily.
Biochimica et biophysica acta 2004;1701(1-2):15-23.
2004: Hormaeche Itsaso; Iloro Ibón; Arrondo José L R; Goñi Félix M; de la Cruz Fernando; Alkorta Itziar
Role of the transmembrane domain in the stability of TrwB, an integral protein involved in bacterial conjugation.
The Journal of biological chemistry 2004;279(12):10955-61.
2004: Francia M Victoria; Varsaki Athanasia; Garcillán-Barcia M Pilar; Latorre Amparo; Drainas Constantin; de la Cruz Fernando
A classification scheme for mobilization regions of bacterial plasmids.
FEMS microbiology reviews 2004;28(1):79-100.
2003: Guasch Alicia; Lucas María; Moncalián Gabriel; Cabezas Matilde; Pérez-Luque Rosa; Gomis-Rüth F Xavier; de la Cruz Fernando; Coll Miquel
Recognition and processing of the origin of transfer DNA by conjugative relaxase TrwC.
Nature structural biology 2003;10(12):1002-10.
2003: Llosa Matxalen; Zunzunegui Sandra; de la Cruz Fernando
Conjugative coupling proteins interact with cognate and heterologous VirB10-like proteins while exhibiting specificity for cognate relaxosomes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10465-70.
2003: Arrondo José-Luis R; Echabe Izaskun; Iloro Ibón; Hernando Miguel-Angel; de la Cruz Fernando; Goñi Félix M
A bacterial TrwC relaxase domain contains a thermally stable alpha-helical core.
Journal of bacteriology 2003;185(14):4226-32.
2003: Varsaki Athanasia; Lucas María; Afendra Amalia S; Drainas Constantin; de la Cruz Fernando
Genetic and biochemical characterization of MbeA, the relaxase involved in plasmid ColE1 conjugative mobilization.
Molecular microbiology 2003;48(2):481-93.
2002: Hormaeche Itsaso; Alkorta Itziar; Moro Fernando; Valpuesta Jose M; Goni Felix M; De La Cruz Fernando
Purification and properties of TrwB, a hexameric, ATP-binding integral membrane protein essential for R388 plasmid conjugation.
The Journal of biological chemistry 2002;277(48):46456-62.
2002: Gomis-Rüth F Xavier; de la Cruz Fernando; Coll Miquel
Structure and role of coupling proteins in conjugal DNA transfer.
Research in microbiology 2002;153(4):199-204.
2002: Machón Cristina; Rivas Susana; Albert Armando; Goñi Félix M; de la Cruz Fernando
TrwD, the hexameric traffic ATPase encoded by plasmid R388, induces membrane destabilization and hemifusion of lipid vesicles.
Journal of bacteriology 2002;184(6):1661-8.
2002: Gomis-Rüth F Xavier; Moncalían Gabriel; de la Cruz Fernando; Coll Miquel
Conjugative plasmid protein TrwB, an integral membrane type IV secretion system coupling protein. Detailed structural features and mapping of the active site cleft.
The Journal of biological chemistry 2002;277(9):7556-66.
2001: Núñez B; De La Cruz F
Two atypical mobilization proteins are involved in plasmid CloDF13 relaxation.
Molecular microbiology 2001;39(4):1088-99.
2001: Gomis-Rüth F X; Moncalián G; Pérez-Luque R; González A; Cabezón E; de la Cruz F; Coll M
The bacterial conjugation protein TrwB resembles ring helicases and F1-ATPase.
Nature 2001;409(6820):637-41.
2001: del Pilar Garcillán-Barcia M; Bernales I; Mendiola M V; de la Cruz F
Single-stranded DNA intermediates in IS91 rolling-circle transposition.
Molecular microbiology 2001;39(2):494-501.
2000: Grandoso G; Avila P; Cayón A; Hernando M A; Llosa M; de la Cruz F
Two active-site tyrosyl residues of protein TrwC act sequentially at the origin of transfer during plasmid R388 conjugation.
Journal of molecular biology 2000;295(5):1163-72.
1999: Moncalián G; Cabezón E; Alkorta I; Valle M; Moro F; Valpuesta J M; Goñi F M; de La Cruz F
Characterization of ATP and DNA binding activities of TrwB, the coupling protein essential in plasmid R388 conjugation.
The Journal of biological chemistry 1999;274(51):36117-24.
1999: Francia M V; Zabala J C; de la Cruz F; García Lobo J M
The IntI1 integron integrase preferentially binds single-stranded DNA of the attC site.
Journal of bacteriology 1999;181(21):6844-9.
1999: Bernales I; Mendiola M V; de la Cruz F
Intramolecular transposition of insertion sequence IS91 results in second-site simple insertions.
Molecular microbiology 1999;33(2):223-34.
1999: Moncalián G; Valle M; Valpuesta J M; de la Cruz F
IHF protein inhibits cleavage but not assembly of plasmid R388 relaxosomes.
Molecular microbiology 1999;31(6):1643-52.
1998: Sastre J I; Cabezón E; de la Cruz F
The carboxyl terminus of protein TraD adds specificity and efficiency to F-plasmid conjugative transfer.
Journal of bacteriology 1998;180(22):6039-42.
1997: Rivas S; Bolland S; Cabezón E; Goñi F M; de la Cruz F
TrwD, a protein encoded by the IncW plasmid R388, displays an ATP hydrolase activity essential for bacterial conjugation.
The Journal of biological chemistry 1997;272(41):25583-90.
1997: Moncalián G; Grandoso G; Llosa M; de la Cruz F
oriT-processing and regulatory roles of TrwA protein in plasmid R388 conjugation.
Journal of molecular biology 1997;270(2):188-200.
1997: Francia M V; Avila P; de la Cruz F; García Lobo J M
A hot spot in plasmid F for site-specific recombination mediated by Tn21 integron integrase.
Journal of bacteriology 1997;179(13):4419-25.
1997: Núñez B; Avila P; de la Cruz F
Genes involved in conjugative DNA processing of plasmid R6K.
Molecular microbiology 1997;24(6):1157-68.
1997: Cabezón E; Sastre J I; de la Cruz F
Genetic evidence of a coupling role for the TraG protein family in bacterial conjugation.
Molecular & general genetics : MGG 1997;254(4):400-6.
1996: Llosa M; Grandoso G; Hernando M A; de la Cruz F
Functional domains in protein TrwC of plasmid R388: dissected DNA strand transferase and DNA helicase activities reconstitute protein function.
Journal of molecular biology 1996;264(1):56-67.
1996: Avila P; Núñez B; de la Cruz F
Plasmid R6K contains two functional oriTs which can assemble simultaneously in relaxosomes in vivo.
Journal of molecular biology 1996;261(2):135-43.
1995: Llosa M; Grandoso G; de la Cruz F
Nicking activity of TrwC directed against the origin of transfer of the IncW plasmid R388.
Journal of molecular biology 1995;246(1):54-62.
1995: Jubete Y; Zabala J C; Juárez A; de la Cruz F
hlyM, a transcriptional silencer downstream of the promoter in the hly operon of Escherichia coli.
Journal of bacteriology 1995;177(1):242-6.
1994: Grandoso G; Llosa M; Zabala J C; de la Cruz F
Purification and biochemical characterization of TrwC, the helicase involved in plasmid R388 conjugal DNA transfer.
European journal of biochemistry / FEBS 1994;226(2):403-12.
1994: Cabezón E; Lanka E; de la Cruz F
Requirements for mobilization of plasmids RSF1010 and ColE1 by the IncW plasmid R388: trwB and RP4 traG are interchangeable.
Journal of bacteriology 1994;176(14):4455-8.
1994: Llosa M; Bolland S; Grandoso G; de la Cruz F
Conjugation-independent, site-specific recombination at the oriT of the IncW plasmid R388 mediated by TrwC.
Journal of bacteriology 1994;176(11):3210-7.
1994: Mendiola M V; Bernales I; de la Cruz F
Differential roles of the transposon termini in IS91 transposition.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1922-6.
1994: Llosa M; Bolland S; de la Cruz F
Genetic organization of the conjugal DNA processing region of the IncW plasmid R388.
Journal of molecular biology 1994;235(2):448-64.
1993: Francia M V; de la Cruz F; García Lobo J M
Secondary-sites for integration mediated by the Tn21 integrase.
Molecular microbiology 1993;10(4):823-8.
1993: Carmona M; Balsalobre C; Muñoa F; Mouriño M; Jubete Y; De la Cruz F; Juárez A
Escherichia coli hha mutants, DNA supercoiling and expression of the haemolysin genes from the recombinant plasmid pANN202-312.
Molecular microbiology 1993;9(5):1011-8.
1992: Mendiola M V; de la Cruz F
IS91 transposase is related to the rolling-circle-type replication proteins of the pUB110 family of plasmids.
Nucleic acids research 1992;20(13):3521.
1992: Mendiola M V; Jubete Y; de la Cruz F
DNA sequence of IS91 and identification of the transposase gene.
Journal of bacteriology 1992;174(4):1345-51.
1991: Llosa M; Jubete Y; de la Cruz F
Tn5tac1 insertion polarity in Escherichia coli.
Plasmid 1991;26(3):222-4.
1991: Avila P; de la Cruz F
Site-specific recombination and shuffling of resistance genes in transposon Tn21.
Research in microbiology 1991;142(6):701-4.
1991: Bartolomé B; Jubete Y; Martínez E; de la Cruz F
Construction and properties of a family of pACYC184-derived cloning vectors compatible with pBR322 and its derivatives.
Gene 1991;102(1):75-8.
1991: Llosa M; Bolland S; de la Cruz F
Structural and functional analysis of the origin of conjugal transfer of the broad-host-range IncW plasmid R388 and comparison with the related IncN plasmid R46.
Molecular & general genetics : MGG 1991;226(3):473-83.
1991: Nieto J M; Carmona M; Bolland S; Jubete Y; de la Cruz F; Juárez A
The hha gene modulates haemolysin expression in Escherichia coli.
Molecular microbiology 1991;5(5):1285-93.
1990: Bolland S; Llosa M; Avila P; de la Cruz F
General organization of the conjugal transfer genes of the IncW plasmid R388 and interactions between R388 and IncN and IncP plasmids.
Journal of bacteriology 1990;172(10):5795-802.
1990: Martinez E; de la Cruz F
Genetic elements involved in Tn21 site-specific integration, a novel mechanism for the dissemination of antibiotic resistance genes.
The EMBO journal 1990;9(4):1275-81.
1989: Mendiola M V; de la Cruz F
Specificity of insertion of IS91, an insertion sequence present in alpha-haemolysin plasmids of Escherichia coli.
Molecular microbiology 1989;3(7):979-84.
1989: Martin C; Grinsted J; de la Cruz F
Effects of variation of inverted-repeat sequences on reactions mediated by the transposase of Tn21.
Journal of bacteriology 1989;171(7):3996-4001.
1988: Avila P; de la Cruz F
Physical and genetic map of the IncW plasmid R388.
Plasmid 1988;20(2):155-7.
1988: Martinez E; Bartolomé B; de la Cruz F
pACYC184-derived cloning vectors containing the multiple cloning site and lacZ alpha reporter gene of pUC8/9 and pUC18/19 plasmids.
Gene 1988;68(1):159-62.
1988: Martinez E; de la Cruz F
Transposon Tn21 encodes a RecA-independent site-specific integration system.
Molecular & general genetics : MGG 1988;211(2):320-5.
1987: Diaz-Aroca E; Mendiola M V; Zabala J C; de la Cruz F
Transposition of IS91 does not generate a target duplication.
Journal of bacteriology 1987;169(1):442-3.
1985: Gonzalez-Carreró M I; Zabala J C; de la Cruz F; Ortiz J M
Purification of alpha-hemolysin from an overproducing E. coli strain.
Molecular & general genetics : MGG 1985;199(1):106-10.
1984: Diaz-Aroca E; de la Cruz F; Zabala J C; Ortiz J M
Characterization of the new insertion sequence IS91 from an alpha-hemolysin plasmid of Escherichia coli.
Molecular & general genetics : MGG 1984;193(3):493-9.
1984: Zabala J C; García-Lobo J M; Diaz-Aroca E; de la Cruz F; Ortiz J M
Escherichia coli alpha-haemolysin synthesis and export genes are flanked by a direct repetition of IS91-like elements.
Molecular & general genetics : MGG 1984;197(1):90-7.
1983: de la Cruz F; Zabala J C; Ortiz J M
Hemolysis determinant common to Escherichia coli strains of different O serotypes and origins.
Infection and immunity 1983;41(3):881-7.
1983: Zabala J C; de la Cruz F; Ortiz J M
Relationship of the replication and incompatibility genes of an IncFVI haemolysin plasmid with other F-like haemolysin plasmids.
Journal of general microbiology 1983;129(3):801-7.
1982: Zabala J C; de la Cruz F; Ortiz J M
Several copies of the same insertion sequence are present in alpha-hemolytic plasmids belonging to four different incompatibility groups.
Journal of bacteriology 1982;151(1):472-6.
1980: de la Cruz F; Zabala J C; Ortiz J M
The molecular relatedness among alpha-hemolytic plasmids from various incompatibility groups.
Plasmid 1980;4(1):76-81.

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Fernando de la Cruz

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