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Bas de Laat

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Bieuwke S Dragt; Ellen L van Agtmaal; Bas de Laat; Jan Voorberg
Effect of laminar shear stress on the distribution of Weibel-Palade bodies in endothelial cells.
Vivian X Du; Rob Fijnheer; Johanna A Kremer-Hovinga; Zaverio M Ruggeri; Gwen van Os; Jacques Wollersheim; Philip G de Groot; Ilze Dienava-Verdoold; Bas de Laat
Indications for a protective function of beta2-glycoprotein I in thrombotic thrombocytopenic purpura.
Bas de Laat; Martijn F Gebbink; Berdien Siregar; Rolf T Urbanus; Miranda van Berkel; Philip G de Groot; Coen Maas
Immune responses against domain I of β(2)-glycoprotein I are driven by conformational changes: domain I of β(2)-glycoprotein I harbors a cryptic immunogenic epitope.

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All Publications

2012: Bieuwke S Dragt; Ellen L van Agtmaal; Bas de Laat; Jan Voorberg
Effect of laminar shear stress on the distribution of Weibel-Palade bodies in endothelial cells.
Thrombosis research 2012;130(5):741-5.
2012: Vivian X Du; Rob Fijnheer; Johanna A Kremer-Hovinga; Zaverio M Ruggeri; Gwen van Os; Jacques Wollersheim; Philip G de Groot; Ilze Dienava-Verdoold; Bas de Laat
Indications for a protective function of beta2-glycoprotein I in thrombotic thrombocytopenic purpura.
British journal of haematology 2012;159(1):94-103.
2011: Bas de Laat; Martijn F Gebbink; Berdien Siregar; Rolf T Urbanus; Miranda van Berkel; Philip G de Groot; Coen Maas
Immune responses against domain I of β(2)-glycoprotein I are driven by conformational changes: domain I of β(2)-glycoprotein I harbors a cryptic immunogenic epitope.
Arthritis and rheumatism 2011;63(12):3960-8.
2011: Beverley J Hunt; Alan A Arslan; Bas de Laat; Sara Stuart-Smith; Xiao-Xuan Wu; Jacob H Rand
Resistance to annexin A5 anticoagulant activity in women with histories for obstetric antiphospholipid syndrome.
American journal of obstetrics and gynecology 2011;205(5):485.e17-23.
2011: Jakub Swadzba; M Pulka; Philip G de Groot; Bas de Laat; Teresa Iwaniec; Jacek Musial
Lupus anticoagulant: performance of the tests as recommended by the latest ISTH guidelines.
Journal of thrombosis and haemostasis : JTH 2011;9(9):1776-83.
2011: Cetin Agar; Philip G de Groot; Bas de Laat; Heiko Herwald; Johannes Levels; Stephanie D D C Monk; Matthias Mörgelin; Rolf T Urbanus; Tom van der Poll; Gwendolyn van Os; Joost C M Meijers
β₂-glycoprotein I: a novel component of innate immunity.
Blood 2011;117(25):6939-47.
2011: I Dienava-Verdoold; M G Boon-Spijker; Philip G de Groot; Herm-Jan Brinkman; Jan Voorberg; Koen Mertens; R H W M Derksen; Bas de Laat
Patient-derived monoclonal antibodies directed towards beta2 glycoprotein-1 display lupus anticoagulant activity.
Journal of thrombosis and haemostasis : JTH 2011;9(4):738-47.
2011: Bas de Laat; Philip G de Groot
Autoantibodies directed against domain I of beta2-glycoprotein I.
Current rheumatology reports 2011;13(1):70-6.
2011: Bas de Laat; R H W M Derksen; G Reber; J Musial; J Swadzba; B Bozic; S Cucnik; V Regnault; R Forastiero; B J Woodhams; Ph G De Groot
An international multicentre-laboratory evaluation of a new assay to detect specifically lupus anticoagulants dependent on the presence of anti-beta2-glycoprotein autoantibodies.
Journal of thrombosis and haemostasis : JTH 2011;9(1):149-53.
2010: R T Urbanus; Bas de Laat
Antiphospholipid antibodies and the protein C pathway.
Lupus 2010;19(4):394-9.
2007: Janine J J Hulstein; Peter J Lenting; Bas de Laat; R H W M Derksen; Rob Fijnheer; Philip G de Groot
beta2-Glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation.
Blood 2007;110(5):1483-91.
2007: Bas de Laat; Xiao-Xuan Wu; Menno van Lummel; R H W M Derksen; Philip G de Groot; Jacob H Rand
Correlation between antiphospholipid antibodies that recognize domain I of beta2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5.
Blood 2007;109(4):1490-4.
2006: Bas de Laat; R H W M Derksen; I J Mackie; M Roest; Selene Schoormans; B J Woodhams; Philip G de Groot; Waander L van Heerde
Annexin A5 polymorphism (-1C-->T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome.
Annals of the rheumatic diseases 2006;65(11):1468-72.
2006: Bas de Laat; R H W M Derksen; Philip G de Groot
High-avidity anti-beta glycoprotein I antibodies highly correlate with thrombosis in contrast to low-avidity anti-beta glycoprotein I antibodies.
Journal of thrombosis and haemostasis : JTH 2006;4(7):1619-21.
2006: Bas de Laat; R H W M Derksen; Menno van Lummel; M T T Pennings; Philip G de Groot
Pathogenic anti-beta2-glycoprotein I antibodies recognize domain I of beta2-glycoprotein I only after a conformational change.
Blood 2006;107(5):1916-24.
2005: Bas de Laat; R H W M Derksen; Rolf T Urbanus; Philip G de Groot
IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta 2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosis.
Blood 2005;105(4):1540-5.