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Elizabeth de Lange

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Jasper Stevens; Piet H van Der Graaf; Meindert Danhof; Margareta Hammarlund-Udenaes; Gunilla Osswald; Bart A Ploeger; Elizabeth C M de Lange
Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans.
Joost Westerhout; Meindert Danhof; Bart A Ploeger; Jean Smeets; Elizabeth C M de Lange
Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats.
Joost Verbeek; Rob A Voskuyl; Elizabeth C M de Lange; Jonas Eriksson; Maaike Labots; Adriaan A Lammertsma; Martinus P J Mooijer; Marissa Rongen; Stina Syvänen; Albert D Windhorst
[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats.

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All Publications

2012: Jasper Stevens; Piet H van Der Graaf; Meindert Danhof; Margareta Hammarlund-Udenaes; Gunilla Osswald; Bart A Ploeger; Elizabeth C M de Lange
Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans.
Journal of pharmacokinetics and pharmacodynamics 2012;39(5):463-77.
2012: Joost Westerhout; Meindert Danhof; Bart A Ploeger; Jean Smeets; Elizabeth C M de Lange
Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats.
The AAPS journal 2012;14(3):543-53.
2012: Joost Verbeek; Rob A Voskuyl; Elizabeth C M de Lange; Jonas Eriksson; Maaike Labots; Adriaan A Lammertsma; Martinus P J Mooijer; Marissa Rongen; Stina Syvänen; Albert D Windhorst
[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats.
EJNMMI research 2012;2(1):36.
2011: Jasper Stevens; Piet H van Der Graaf; Meindert Danhof; Bart A Ploeger; Elizabeth C M de Lange
Systemic and direct nose-to-brain transport pharmacokinetic model for remoxipride after intravenous and intranasal administration.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(12):2275-82.
2011: Joost Westerhout; Meindert Danhof; Elizabeth C M de Lange
Preclinical prediction of human brain target site concentrations: considerations in extrapolating to the clinical setting.
Journal of pharmaceutical sciences 2011;100(9):3577-93.
2010: Gijs Kooij; Jack van Horssen; Elizabeth C M de Lange; Arie Reijerkerk; Susanne M A van der Pol; Bert Van het Hof; Joost Drexhage; Anke Vennegoor; Joep Killestein; George Scheffer; Ruud Oerlemans; Rik Scheper; Paul Van Der Valk; Christine D Dijkstra; Helga E de Vries
T lymphocytes impair P-glycoprotein function during neuroinflammation.
Journal of autoimmunity 2010;34(4):416-25.
2010: Jasper Stevens; Dirk-Jan van den Berg; Sanne de Ridder; Harm A G Niederländer; Piet Hein van der Graaf; Meindert Danhof; Elizabeth C M de Lange
Online solid phase extraction with liquid chromatography-tandem mass spectrometry to analyze remoxipride in small plasma-, brain homogenate-, and brain microdialysate samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(13-14):969-75.
2009: Jasper Stevens; Ernst Suidgeest; Piet H van Der Graaf; Meindert Danhof; Elizabeth C M de Lange
A new minimal-stress freely-moving rat model for preclinical studies on intranasal administration of CNS drugs.
Pharmaceutical research 2009;26(8):1911-7.
2009: Thomas I F H Cremers; Martin G de Vries; Kirsten D Huinink; Jan Paul van Loon; Marieke v d Hart; Bjarke Ebert; Ben H C Westerink; Elizabeth C M de Lange
Quantitative microdialysis using modified ultraslow microdialysis: direct rapid and reliable determination of free brain concentrations with the MetaQuant technique.
Journal of neuroscience methods 2009;178(2):249-54.
2008: Dorien Groenendaal; Jan Freijer; Andrea Rosier; Dennis de Mik; Glynis Nicholls; Anne Hersey; Andrew Ayrton; Meindert Danhof; Elizabeth C M de Lange
Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;34(2-3):149-63.
2008: Meindert Danhof; Elizabeth C M de Lange; Oscar Della-Pasqua; Bart A Ploeger; Rob A Voskuyl
Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research.
Trends in pharmacological sciences 2008;29(4):186-91.
2008: Tamara J van Steeg; Jan Freijer; Meindert Danhof; Elizabeth C M de Lange
Mechanism-based pharmacodynamic modeling of S(-)-atenolol: estimation of in vivo affinity for the beta1-adrenoceptor with an agonist-antagonist interaction model.
The Journal of pharmacology and experimental therapeutics 2008;324(3):1234-42.
2008: Paulien G M Ravenstijn; Mario Merlini; Marjolijn Hameetman; Tracey K Murray; Mark A Ward; Hywel Lewis; Gareth Ball; Cathy Mottart; Christine de Ville de Goyet; Thomas Xavier Lemarchand; Kristel van Belle; Michael J O'Neill; Meindert Danhof; Elizabeth C M de Lange
The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments.
Journal of pharmacological and toxicological methods 2008;57(2):114-30.
2007: Dorien Groenendaal; Jan Freijer; D de Mik; M R Bouw; Meindert Danhof; Elizabeth C M de Lange
Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux.
British journal of pharmacology 2007;151(5):701-12.
2007: Dorien Groenendaal; Jan Freijer; D de Mik; M R Bouw; Meindert Danhof; Elizabeth C M de Lange
Influence of biophase distribution and P-glycoprotein interaction on pharmacokinetic-pharmacodynamic modelling of the effects of morphine on the EEG.
British journal of pharmacology 2007;151(5):713-20.
2007: Tamara J van Steeg; Elke H J Krekels; Meindert Danhof; Elizabeth C M de Lange
Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats.
Journal of pharmacological and toxicological methods 2007;56(1):72-8.
2007: Tamara J van Steeg; Jan Freijer; Meindert Danhof; Elizabeth C M de Lange
Pharmacokinetic-pharmacodynamic modelling of S(-)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint.
British journal of pharmacology 2007;151(3):356-66.
2007: Meindert Danhof; Joost de Jongh; Elizabeth C M de Lange; Oscar Della-Pasqua; Bart A Ploeger; Rob A Voskuyl
Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis.
Annual review of pharmacology and toxicology 2007;47():357-400.
2005: Elizabeth C M de Lange; Paulien G M Ravenstijn; Dorien Groenendaal; Tamara J van Steeg
Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling.
The AAPS journal 2005;7(3):E532-43.
2004: Elizabeth C M de Lange
Potential role of ABC transporters as a detoxification system at the blood-CSF barrier.
Advanced drug delivery reviews 2004;56(12):1793-809.
2004: Gert Luurtsema; Elizabeth C M de Lange; Adriaan A Lammertsma; Eric J F Franssen
Transport across the blood-brain barrier: stereoselectivity and PET-tracers.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2004;6(5):306-18.
2002: Adriaan M Karssen; Onno C Meijer; I C J van der Sandt; Albertus G de Boer; Elizabeth C M de Lange; Ron de Kloet
The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone.
The Journal of endocrinology 2002;175(1):251-60.
2002: Elizabeth C M de Lange; Meindert Danhof
Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.
Clinical pharmacokinetics 2002;41(10):691-703.
2001: Adriaan M Karssen; Onno C Meijer; I C J van der Sandt; P J Lucassen; Elizabeth C M de Lange; Albertus G de Boer; Ron de Kloet
Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain.
Endocrinology 2001;142(6):2686-94.
2000: Elizabeth C M de Lange; Albertus G de Boer; Douwe D Breimer
Methodological issues in microdialysis sampling for pharmacokinetic studies.
Advanced drug delivery reviews 2000;45(2-3):125-48.
2000: Elizabeth C M de Lange; Sandrine Marchand; D van den Berg; I C J van der Sandt; Albertus G de Boer; A Delon; Serge Bouquet; William Couet
In vitro and in vivo investigations on fluoroquinolones; effects of the P-glycoprotein efflux transporter on brain distribution of sparfloxacin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;12(2):85-93.
1998: Elizabeth C M de Lange; G de Bock; A H Schinkel; Albertus G de Boer; Douwe D Breimer
BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123.
Pharmaceutical research 1998;15(11):1657-65.
1998: Onno C Meijer; Elizabeth C M de Lange; Douwe D Breimer; Albertus G de Boer; JO Workel; Ron de Kloet
Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice.
Endocrinology 1998;139(4):1789-93.
1997: Elizabeth C M de Lange; Meindert Danhof; Albertus G de Boer; Douwe D Breimer
Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier.
Brain research. Brain research reviews 1997;25(1):27-49.