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Laura De Luca

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TOP 3
Laura De Luca; Francesca Morreale; Alba Chimirri
Insight into the fundamental interactions between LEDGF binding site inhibitors and integrase combining docking and molecular dynamics simulations.
Rosaria Gitto; Emilio Russo; Maria R Buemi; Mariangela Chisari; Lucia Ciranna; Laura De Luca; Giovambattista De Sarro; Stefania Ferro; Alba Chimirri
Synthesis and biological characterization of 3-substituted 1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. Part 2.
Rosaria Gitto; Pavel Mader; Pavlína Rezáčová; Claudiu T Supuran; Daniela Vullo; Jirí Brynda; Francesca M Damiano; Laura De Luca; Stefania Ferro; Alba Chimirri
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.

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All Publications

2012: Laura De Luca; Francesca Morreale; Alba Chimirri
Insight into the fundamental interactions between LEDGF binding site inhibitors and integrase combining docking and molecular dynamics simulations.
Journal of chemical information and modeling 2012;52(12):3245-54.
2012: Rosaria Gitto; Emilio Russo; Maria R Buemi; Mariangela Chisari; Lucia Ciranna; Laura De Luca; Giovambattista De Sarro; Stefania Ferro; Alba Chimirri
Synthesis and biological characterization of 3-substituted 1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. Part 2.
Journal of medicinal chemistry 2012;55(23):10532-9.
2012: Rosaria Gitto; Pavel Mader; Pavlína Rezáčová; Claudiu T Supuran; Daniela Vullo; Jirí Brynda; Francesca M Damiano; Laura De Luca; Stefania Ferro; Alba Chimirri
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.
Journal of medicinal chemistry 2012;55(8):3891-9.
2012: Rosaria Gitto; Sara De Grazia; Laura De Luca; Alba Chimirri
Glutamatergic neurotransmission as molecular target of new anticonvulsants.
Current topics in medicinal chemistry 2012;12(9):971-93.
2011: Rosaria Gitto; Claudiu T Supuran; Daniela Vullo; Francesca Maria Damiano; Laura De Luca; Stefania Ferro; Alba Chimirri
Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors.
Bioorganic & medicinal chemistry 2011;19(23):7003-7.
2011: Laura De Luca; zeger debyser; Stefania Ferro; Rosaria Gitto; Francesca Morreale; Frauke Christ; Sara De Grazia; Alba Chimirri
4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process.
Antiviral research 2011;92(1):102-7.
2011: Laura De Luca; Stefania Ferro; Francesca Morreale; Sara De Grazia; Alba Chimirri
Inhibitors of the interactions between HIV-1 IN and the cofactor LEDGF/p75.
ChemMedChem 2011;6(7):1184-91.
2011: Laura De Luca; Sara De Grazia; Stefania Ferro; Rosaria Gitto; Frauke Christ; zeger debyser; Alba Chimirri
HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation.
European journal of medicinal chemistry 2011;46(2):756-64.
2011: Stefania Ferro; Rosaria Gitto; Sara De Grazia; Laura De Luca; Zeger Debyzer; Caterina Elisa Faliti; Alba Chimirri
Microwave assisted organic synthesis (MAOS) of small molecules as potential HIV-1 integrase inhibitors.
Molecules (Basel, Switzerland) 2011;16(8):6858-70.
2010: Rosaria Gitto; Laura De Luca; Stefania Ferro; Stefano Agnello; Emilio Russo; Giovanbattista De Sarro; Alba Chimirri
Synthesis and structure-active relationship of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline anticonvulsants.
Chemical & pharmaceutical bulletin 2010;58(12):1602-5.
2010: Laura De Luca; Stefania Ferro; Rosaria Gitto; Maria Letizia Barreca; Stefano Agnello; Frauke Christ; zeger debyser; Alba Chimirri
Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor.
Bioorganic & medicinal chemistry 2010;18(21):7515-21.
2010: Stefania Ferro; Laura De Luca; Maria Letizia Barreca; Sara De Grazia; Frauke Christ; zeger debyser; Alba Chimirri
New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action.
Bioorganic & medicinal chemistry 2010;18(15):5510-8.
2010: Rosaria Gitto; Stefano Agnello; Stefania Ferro; Laura De Luca; Daniela Vullo; Jiri Brynda; Pavel Mader; Claudiu T Supuran; Alba Chimirri
Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.
Journal of medicinal chemistry 2010;53(6):2401-8.
2009: Maria Letizia Barreca; Nunzio Iraci; Laura De Luca; Alba Chimirri
Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors.
ChemMedChem 2009;4(9):1446-56.
2009: Laura De Luca; Maria Letizia Barreca; Stefania Ferro; Frauke Christ; Nunzio Iraci; Rosaria Gitto; Anna Maria Monforte; zeger debyser; Alba Chimirri
Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.
ChemMedChem 2009;4(8):1311-6.
2009: Alba Chimirri; Laura De Luca; Stefania Ferro; Giovanbattista De Sarro; Lucia Ciranna; Rosaria Gitto
Combined strategies for the discovery of ionotropic glutamate receptor antagonists.
ChemMedChem 2009;4(6):917-22.
2009: Rosaria Gitto; Stefania Ferro; Stefano Agnello; Laura De Luca; Giovanbattista De Sarro; Emilio Russo; Daniela Vullo; Claudiu T Supuran; Alba Chimirri
Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.
Bioorganic & medicinal chemistry 2009;17(10):3659-64.
2008: Rosaria Gitto; Laura De Luca; Stefania Ferro; Francesco Occhiuto; Stefania Samperi; Giovambattista De Sarro; Emilio Russo; Lucia Ciranna; Lara Costa; Alba Chimirri
Computational studies to discover a new NR2B/NMDA receptor antagonist and evaluation of pharmacological profile.
ChemMedChem 2008;3(10):1539-48.
2008: Rosanna Stancanelli; Vincenza Crupi; Laura De Luca; Paola Ficarra; Rita Ficarra; Rosaria Gitto; Marta Guardo; Nunzio Iraci; Domenico Majolino; Silvana Tommasini; Valentina Venuti
Improvement of water solubility of non-competitive AMPA receptor antagonists by complexation with beta-cyclodextrin.
Bioorganic & medicinal chemistry 2008;16(18):8706-12.
2008: Anna Maria Monforte; Angela Rao; Patrizia Logoteta; Stefania Ferro; Laura De Luca; Maria Letizia Barreca; Nunzio Iraci; giovanni maga; Erik De Clercq; Christophe Pannecouque; Alba Chimirri
Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2008;16(15):7429-35.
2008: Laura De Luca; Maria Letizia Barreca; Stefania Ferro; Nunzio Iraci; Martine Michiels; Frauke Christ; zeger debyser; Myriam Witvrouw; Alba Chimirri
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.
Bioorganic & medicinal chemistry letters 2008;18(9):2891-5.
2008: Rosaria Gitto; Laura De Luca; Benedetta Pagano; Rita Citraro; Giovambattista De Sarro; Lara Costa; Lucia Ciranna; Alba Chimirri
Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists.
Bioorganic & medicinal chemistry 2008;16(5):2379-84.
2007: Maria Letizia Barreca; Francesco Ortuso; Nunzio Iraci; Laura De Luca; Stefano Alcaro; Alba Chimirri
Tn5 transposase as a useful platform to simulate HIV-1 integrase inhibitor binding mode.
Biochemical and biophysical research communications 2007;363(3):554-60.
2007: Rosaria Gitto; Rita Ficarra; Rosanna Stancanelli; Marta Guardo; Laura De Luca; Maria Letizia Barreca; Benedetta Pagano; Archimede Rotondo; Giuseppe Bruno; Emilio Russo; Giovambattista De Sarro; Alba Chimirri
Synthesis, resolution, stereochemistry, and molecular modeling of (R)- and (S)-2-acetyl-1-(4'-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline AMPAR antagonists.
Bioorganic & medicinal chemistry 2007;15(16):5417-23.
2007: Stefania Ferro; Maria Letizia Barreca; Laura De Luca; Angela Rao; Anna Maria Monforte; zeger debyser; Myriam Witvrouw; Alba Chimirri
New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors.
Archiv der Pharmazie 2007;340(6):292-8.
2007: Maria Letizia Barreca; Angela Rao; Laura De Luca; Nunzio Iraci; Anna Maria Monforte; giovanni maga; Erik De Clercq; Christophe Pannecouque; Jan Balzarini; Alba Chimirri
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.
Bioorganic & medicinal chemistry letters 2007;17(7):1956-60.
2007: Maria Letizia Barreca; Laura De Luca; Nunzio Iraci; Angela Rao; Stefania Ferro; giovanni maga; Alba Chimirri
Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors.
Journal of chemical information and modeling 2007;47(2):557-62.
2007: Andrea Savarino; Mauro Pistello; Daniela D'Ostilio; Elisa Zabogli; Fabiana Taglia; Fabiola Mancini; Stefania Ferro; Donatella Matteucci; Laura De Luca; Maria Letizia Barreca; Alessandra Ciervo; Alba Chimirri; Massimo Ciccozzi; Mauro Bendinelli
Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS.
Retrovirology 2007;4():79.
2006: Rosaria Gitto; Roberta Caruso; Benedetta Pagano; Laura De Luca; Rita Citraro; Emilio Russo; Giovambattista De Sarro; Alba Chimirri
Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton.
Journal of medicinal chemistry 2006;49(18):5618-22.
2006: Laura De Luca; Rosaria Gitto; Maria Letizia Barreca; Roberta Caruso; Silvana Quartarone; Rita Citraro; Giovambattista De Sarro; Alba Chimirri
3D pharmacophore models for 1,2,3,4-tetrahydroisoquinoline derivatives acting as anticonvulsant agents.
Archiv der Pharmazie 2006;339(7):388-400.
2006: Maria Letizia Barreca; Laura De Luca; Nunzio Iraci; Alba Chimirri
Binding mode prediction of strand transfer HIV-1 integrase inhibitors using Tn5 transposase as a plausible surrogate model for HIV-1 integrase.
Journal of medicinal chemistry 2006;49(13):3994-7.
2005: Laura De Luca; Giulio Vistoli; Alessandro Pedretti; Maria Letizia Barreca; Alba Chimirri
Molecular dynamics studies of the full-length integrase-DNA complex.
Biochemical and biophysical research communications 2005;336(4):1010-6.
2005: Maria Letizia Barreca; Stefania Ferro; Angela Rao; Laura De Luca; Maria Zappalà; Anna Maria Monforte; zeger debyser; Myriam Witvrouw; Alba Chimirri
Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.
Journal of medicinal chemistry 2005;48(22):7084-8.
2005: Maria Letizia Barreca; Angela Rao; Laura De Luca; Maria Zappalà; Anna Maria Monforte; giovanni maga; Christophe Pannecouque; Jan Balzarini; Erik De Clercq; Alba Chimirri; Pietro Monforte
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.
Journal of medicinal chemistry 2005;48(9):3433-7.
2005: Giovambattista De Sarro; Rosaria Gitto; Emilio Russo; Guido Ferreri Ibbadu; Maria Letizia Barreca; Laura De Luca; Alba Chimirri
AMPA receptor antagonists as potential anticonvulsant drugs.
Current topics in medicinal chemistry 2005;5(1):31-42.
2004: Maria Letizia Barreca; Angela Rao; Laura De Luca; Maria Zappalà; Cristina Gurnari; Pietro Monforte; Erik De Clercq; Bénédicte Van Maele; zeger debyser; Myriam Witvrouw; James M Briggs; Alba Chimirri
Efficient 3D database screening for novel HIV-1 IN inhibitors.
Journal of chemical information and computer sciences 2004;44(4):1450-5.
2004: Antonio Macchiarulo; Laura De Luca; Gabriele Costantino; Maria Letizia Barreca; Rosaria Gitto; Roberto Pellicciari; Alba Chimirri
QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor.
Journal of medicinal chemistry 2004;47(7):1860-3.
2003: Laura De Luca; Alessandro Pedretti; Giulio Vistoli; Maria Letizia Barreca; Luigi Villa; Pietro Monforte; Alba Chimirri
Analysis of the full-length integrase-DNA complex by a modified approach for DNA docking.
Biochemical and biophysical research communications 2003;310(4):1083-8.
2003: Maria Letizia Barreca; Rosaria Gitto; Silvana Quartarone; Laura De Luca; Giovambattista De Sarro; Alba Chimirri
Pharmacophore modeling as an efficient tool in the discovery of novel noncompetitive AMPA receptor antagonists.
Journal of chemical information and computer sciences 2003;43(2):651-5.
2003: Maria Letizia Barreca; Alba Chimirri; Erik De Clercq; Laura De Luca; Anna Maria Monforte; Pietro Monforte; Angela Rao; Maria Zappalà
Anti-HIV agents: design and discovery of new potent RT inhibitors.
Farmaco (Società chimica italiana : 1989) 2003;58(3):259-63.
2003: Laura De Luca; Antonio Macchiarulo; Gabriele Costantino; Maria Letizia Barreca; Rosaria Gitto; Alba Chimirri; Roberto Pellicciari
Binding modes of noncompetitive AMPA antagonists: a computational approach.
Farmaco (Società chimica italiana : 1989) 2003;58(2):107-13.
2003: Rosaria Gitto; Maria Letizia Barreca; Laura De Luca; Giovambattista De Sarro; Guido Ferreri; Silvana Quartarone; Emilio Russo; Andrew Constanti; Alba Chimirri
Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist.
Journal of medicinal chemistry 2003;46(1):197-200.
2002: Maria Letizia Barreca; Jan Balzarini; Alba Chimirri; Erik De Clercq; Laura De Luca; Hans-Dieter Höltje; Monika Höltje; Anna Maria Monforte; Pietro Monforte; Christophe Pannecouque; Angela Rao; Maria Zappalà
Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.
Journal of medicinal chemistry 2002;45(24):5410-3.
2001: Maria Letizia Barreca; Alba Chimirri; Laura De Luca; Anna Maria Monforte; Pietro Monforte; Angela Rao; Maria Zappalà; Jan Balzarini; Erik De Clercq; Christophe Pannecouque; Myriam Witvrouw
Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.
Bioorganic & medicinal chemistry letters 2001;11(13):1793-6.