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Luciano De Petrocellis

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Chemicals & Drugs

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Katarzyna Starowicz; Magdalena Zychowska; Luigia Cristino; Luciano De Petrocellis; Michal Korostynski; Wioletta Makuch; Natalia Malek; Stefania Petrosino; Barbara Przewlocka; Michal Slezak; Vincenzo Di Marzo
Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism.
Luciano De Petrocellis; Aniello Schiano Moriello
2-Amino-4-arylthiazole compounds as TRPA1 antagonists (WO 2012085662): a patent evaluation.
Luciano De Petrocellis; Luigia Cristino; Mariagrazia Iappelli; Alessia Ligresti; Pierangelo Orlando; Aniello Schiano Moriello; Colin G Stott; Roberta Verde; Vincenzo Di Marzo
Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms.

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All Publications

2013: Katarzyna Starowicz; Magdalena Zychowska; Luigia Cristino; Luciano De Petrocellis; Michal Korostynski; Wioletta Makuch; Natalia Malek; Stefania Petrosino; Barbara Przewlocka; Michal Slezak; Vincenzo Di Marzo
Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism.
PloS one 2013;8(4):e60040.
2013: Luciano De Petrocellis; Aniello Schiano Moriello
2-Amino-4-arylthiazole compounds as TRPA1 antagonists (WO 2012085662): a patent evaluation.
Expert opinion on therapeutic patents 2013;23(1):119-47.
2013: Luciano De Petrocellis; Luigia Cristino; Mariagrazia Iappelli; Alessia Ligresti; Pierangelo Orlando; Aniello Schiano Moriello; Colin G Stott; Roberta Verde; Vincenzo Di Marzo
Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms.
British journal of pharmacology 2013;168(1):79-102.
2012: Vincenzo Di Marzo; Luciano De Petrocellis
Why do cannabinoid receptors have more than one endogenous ligand?
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2012;367(1607):3216-28.
2012: Luciano De Petrocellis; Roberta Imperatore; Aniello Schiano Moriello; Katarzyna Starowicz; Luigia Cristino; Vincenzo Di Marzo
A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons.
British journal of pharmacology 2012;167(8):1643-51.
2012: Livio Luongo; Sabatino Maione; Maria Matteis; Nikol Sullo; Francesca Comelli; Barbara Costa; Bruno D'Agostino; Vito de Novellis; Luciano De Petrocellis; Luisa Gatta; F Guida; Vincenzo Di Marzo
Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature.
Pharmacological research : the official journal of the Italian Pharmacological Society 2012;66(3):243-50.
2012: Giorgio Ortar; Aniello Schiano Moriello; Vincenzo Di Marzo; Enrico Morera; Ludovica Morera; Marianna Nalli; Luciano De Petrocellis
Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds.
Bioorganic & medicinal chemistry letters 2012;22(10):3535-9.
2012: Raffaele Capasso; Luciano De Petrocellis; Vincenzo Di Marzo; Gabriella Aviello; Francesca Borrelli; Barbara Romano; Angelo A Izzo
Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects.
British journal of pharmacology 2012;165(6):1966-77.
2012: Enrico Morera; Marianna Nalli; Luciano De Petrocellis; Vincenzo Di Marzo; Ludovica Morera; Aniello Schiano Moriello; Giorgio Ortar
Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators.
Bioorganic & medicinal chemistry letters 2012;22(4):1674-7.
2012: Romina Nassini; Bernd Nilius; Frank Porreca; Jean Prenen; Delia Preti; Laura Sadofsky; Orazio Taglialatela-Scafati; Joris Vriens; Eunice Andrè; Giovanni Appendino; Cristina Avonto; Silvia Benemei; Luciano De Petrocellis; Gaetano De Siena; Vincenzo Di Marzo; Greg Dussor; Giancarlo la Marca; Serena Materazzi; Pierangelo Geppetti
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.
Brain : a journal of neurology 2012;135(Pt 2):376-90.
2012: Luciano De Petrocellis; G Aviello; Angelo A Izzo; Aniello Schiano Moriello; Pierangelo Orlando; C Stott; Vincenzo Di Marzo
Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation.
Acta physiologica (Oxford, England) 2012;204(2):255-66.
2011: Federica Pollastro; Orazio Taglialatela-Scafati; Marco Allarà; Luciano De Petrocellis; Vincenzo Di Marzo; Eduardo Muñoz; Giovani Appendino
Bioactive prenylogous cannabinoid from fiber hemp (Cannabis sativa).
Journal of natural products 2011;74(9):2019-22.
2011: Luciano De Petrocellis; Marco Allarà; Tiziana Bisogno; Alessia Ligresti; Aniello Schiano Moriello; Stefania Petrosino; Colin G Stott; Vincenzo Di Marzo
Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes.
British journal of pharmacology 2011;163(7):1479-94.
2011: Luciano De Petrocellis; Vincenzo Di Marzo
Cell signalling: why fasting worms age slowly.
Nature 2011;473(7346):161-3.
2011: Francesca Rossi; Giulia Bellini; Livio Luongo; Michele Torella; Silvia Mancusi; Luciano De Petrocellis; Stefania Petrosino; Dario Siniscalco; Pierangelo Orlando; Mariantonietta Scafuro; Nicola Colacurci; Silverio Perrotta; Bruno Nobili; Vincenzo Di Marzo; Sabatino Maione
The endovanilloid/endocannabinoid system: a new potential target for osteoporosis therapy.
Bone 2011;48(5):997-1007.
2011: Luciano De Petrocellis; F Guida; Aniello Schiano Moriello; Maria De Chiaro; Fabiana Piscitelli; Vito de Novellis; Sabatino Maione; Vincenzo Di Marzo
N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;63(4):294-9.
2011: Sabatino Maione; Fabiana Piscitelli; Luisa Gatta; Daniela Vita; Luciano De Petrocellis; Enza Palazzo; Vito de Novellis; Vincenzo Di Marzo
Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action.
British journal of pharmacology 2011;162(3):584-96.
2011: Cristina Avonto; Orazio Taglialatela-Scafati; Federica Pollastro; Alberto Minassi; Vincenzo Di Marzo; Luciano De Petrocellis; Giovanni Appendino
An NMR spectroscopic method to identify and classify thiol-trapping agents: revival of Michael acceptors for drug discovery?
Angewandte Chemie (International ed. in English) 2011;50(2):467-71.
2010: Marina Piscopo; Mariachiara Conte; Flaviano Di Paola; Salvatore Conforti; Gina Rana; Luciano De Petrocellis; Laura Fucci; Giuseppe Geraci
Relevance of arginines in the mode of binding of H1 histones to DNA.
DNA and cell biology 2010;29(7):339-47.
2010: Giorgio Ortar; Luciano De Petrocellis; Ludovica Morera; Aniello Schiano Moriello; Pierangelo Orlando; Enrico Morera; Marianna Nalli; Vincenzo Di Marzo
(-)-Menthylamine derivatives as potent and selective antagonists of transient receptor potential melastatin type-8 (TRPM8) channels.
Bioorganic & medicinal chemistry letters 2010;20(9):2729-32.
2010: Luciano De Petrocellis; Vincenzo Di Marzo
Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2010;5(1):103-21.
2010: Gilda Cobellis; Giulia Ricci; Giovanna Cacciola; Pierangelo Orlando; Stefania Petrosino; Maria Grazia Cascio; Tiziana Bisogno; Luciano De Petrocellis; Teresa Chioccarelli; Lucia Altucci; Silvia Fasano; Rosaria Meccariello; Riccardo Pierantoni; Catherine Ledent; Vincenzo Di Marzo
A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up.
Biology of reproduction 2010;82(2):451-8.
2010: Alessia Ligresti; Luciano De Petrocellis; Dolores Hernán Pérez de la Ossa; Rosario Aberturas; Luigia Cristino; Aniello Schiano Moriello; Andrea Finizio; M Esther Gil; Ana-Isabel Torres; Jesús Molpeceres; Vincenzo Di Marzo
Exploiting nanotechnologies and TRPV1 channels to investigate the putative anandamide membrane transporter.
PloS one 2010;5(4):e10239.
2010: Giovanni Appendino; Abdellah Ech-Chahad; Alberto Minassi; Luciano De Petrocellis; Vincenzo Di Marzo
Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene.
Bioorganic & medicinal chemistry letters 2010;20(1):97-9.
2009: Enrico Morera; Luciano De Petrocellis; Ludovica Morera; Aniello Schiano Moriello; Alessia Ligresti; Marianna Nalli; David F Woodward; Vincenzo Di Marzo; Giorgio Ortar
Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands.
Bioorganic & medicinal chemistry letters 2009;19(23):6806-9.
2009: Paola Grimaldi; Pierangelo Orlando; Sara Di Siena; Francesca Lolicato; Stefania Petrosino; Tiziana Bisogno; raffaele geremia; Luciano De Petrocellis; Vincenzo Di Marzo
The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(27):11131-6.
2009: Pietro Marini; Aniello Schiano Moriello; Luigia Cristino; Maura Palmery; Luciano De Petrocellis; Vincenzo Di Marzo
Cannabinoid CB1 receptor elevation of intracellular calcium in neuroblastoma SH-SY5Y cells: interactions with muscarinic and delta-opioid receptors.
Biochimica et biophysica acta 2009;1793(7):1289-303.
2009: Luciano De Petrocellis; Vincenzo Di Marzo
Role of endocannabinoids and endovanilloids in Ca2+ signalling.
Cell calcium 2009;45(6):611-24.
2009: Giovanni Appendino; Alessia Ligresti; Alberto Minassi; Maria Grazia Cascio; Marco Allarà; Orazio Taglialatela-Scafati; Roger G Pertwee; Luciano De Petrocellis; Vincenzo Di Marzo
Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes.
Journal of medicinal chemistry 2009;52(9):3001-9.
2009: Francesca Rossi; Dario Siniscalco; L Luongo; Luciano De Petrocellis; G Bellini; Stefania Petrosino; Michele Torella; C Santoro; B Nobili; S Perrotta; Vincenzo Di Marzo; Sabatino Maione
The endovanilloid/endocannabinoid system in human osteoclasts: possible involvement in bone formation and resorption.
Bone 2009;44(3):476-84.
2009: Luciano De Petrocellis; Vincenzo Di Marzo
An introduction to the endocannabinoid system: from the early to the latest concepts.
Best practice & research. Clinical endocrinology & metabolism 2009;23(1):1-15.
2008: Vito de Novellis; Enza Palazzo; Francesca Rossi; Luciano De Petrocellis; Stefania Petrosino; Francesca Guida; Livio Luongo; Annalucia Migliozzi; Luigia Cristino; Ida Marabese; Katarzyna Starowicz; Vincenzo Di Marzo; Sabatino Maione
The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats.
Neuropharmacology 2008;55(7):1105-13.
2008: Vittorio Vellani; Stefania Petrosino; Luciano De Petrocellis; Marta Valenti; Massimiliano Prandini; Pier Cosimo Magherini; Peter A McNaughton; Vincenzo Di Marzo
Functional lipidomics. Calcium-independent activation of endocannabinoid/endovanilloid lipid signalling in sensory neurons by protein kinases C and A and thrombin.
Neuropharmacology 2008;55(8):1274-9.
2008: Luciano De Petrocellis; Vittorio Vellani; Aniello Schiano Moriello; Pietro Marini; Pier Cosimo Magherini; Pierangelo Orlando; Vincenzo Di Marzo
Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8.
The Journal of pharmacology and experimental therapeutics 2008;325(3):1007-15.
2008: Giorgio Ortar; Aniello Schiano Moriello; Maria Grazia Cascio; Luciano De Petrocellis; Alessia Ligresti; Enrico Morera; Marianna Nalli; Vincenzo Di Marzo
New tetrazole-based selective anandamide uptake inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(9):2820-4.
2008: Luigia Cristino; Katarzyna Starowicz; Luciano De Petrocellis; J Morishita; N Ueda; Vittorio Guglielmotti; Vincenzo Di Marzo
Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain.
Neuroscience 2008;151(4):955-68.
2007: Giorgio Ortar; Maria Grazia Cascio; Luciano De Petrocellis; Enrico Morera; Francesca Rossi; Aniello Schiano Moriello; Marianna Nalli; Vito de Novellis; David F Woodward; Sabatino Maione; Vincenzo Di Marzo
New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain.
Journal of medicinal chemistry 2007;50(26):6554-69.
2007: Carmela Della Monica; Luciano De Petrocellis; Vincenzo Di Marzo; Raffaella Landi; Irene Izzo; Aldo Spinella
Enantioselective synthesis and vanilloid activity evaluation of 1-beta-(p-methoxycinnamoyl)polygodial, an antinociceptive compound from Drymis winteri barks.
Bioorganic & medicinal chemistry letters 2007;17(23):6444-7.
2007: Luciano De Petrocellis; Pietro Marini; Isabel Matias; Aniello Schiano Moriello; Katarzyna Starowicz; Luigia Cristino; Santosh Nigam; Vincenzo Di Marzo
Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells.
Experimental cell research 2007;313(14):2993-3004.
2007: Vincenzo Di Marzo; Tiziana Bisogno; Luciano De Petrocellis
Endocannabinoids and related compounds: walking back and forth between plant natural products and animal physiology.
Chemistry & biology 2007;14(7):741-56.
2007: Luciano De Petrocellis; Katarzyna Starowicz; Aniello Schiano Moriello; Marta Vivese; Pierangelo Orlando; Vincenzo Di Marzo
Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloids.
Experimental cell research 2007;313(9):1911-20.
2007: Anna Maria Malfitano; gokce toruner; Patrizia Gazzerro; Chiara Laezza; Seema Husain; davide laptop; Pierangelo Orlando; Luciano De Petrocellis; Alexandra Terskiy; Marvin N Schwalb; Emilia Vitale; Maurizio Bifulco
Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells.
Immunology letters 2007;109(2):145-54.
2007: Sabatino Maione; Luciano De Petrocellis; Vito de Novellis; Aniello Schiano Moriello; Stefania Petrosino; Enza Palazzo; F Sca Rossi; David F Woodward; Vincenzo Di Marzo
Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors.
British journal of pharmacology 2007;150(6):766-81.
2007: Giovanni Appendino; Sara Bacchiega; Alberto Minassi; Maria Grazia Cascio; Luciano De Petrocellis; Vincenzo Di Marzo
The 1,2,3-triazole ring as a peptido- and olefinomimetic element: discovery of click vanilloids and cannabinoids.
Angewandte Chemie (International ed. in English) 2007;46(48):9312-5.
2007: Giovanni Appendino; Abdellah Ech-Chahad; Alberto Minassi; Sara Bacchiega; Luciano De Petrocellis; Vincenzo Di Marzo
Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): the homovanillyl moiety.
Bioorganic & medicinal chemistry letters 2007;17(1):132-5.
2006: Silvia Santillo; Pierangelo Orlando; Luciano De Petrocellis; Luigia Cristino; Vittorio Guglielmotti; CARLO MUSIO
Evolving visual pigments: hints from the opsin-based proteins in a phylogenetically old "eyeless" invertebrate.
Bio Systems 2006;86(1-3):3-17.
2006: Alessia Ligresti; Aniello Schiano Moriello; Katarzyna Starowicz; Isabel Matias; Simona Pisanti; Luciano De Petrocellis; Chiara Laezza; Giuseppe Portella; Maurizio Bifulco; Vincenzo Di Marzo
Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma.
The Journal of pharmacology and experimental therapeutics 2006;318(3):1375-87.
2006: Isabel Matias; Marie-Paule Gonthier; Pierangelo Orlando; Vassilis Martiadis; Luciano De Petrocellis; Cristina Cervino; Stefania Petrosino; Laurence Hoareau; Franck Festy; Renato Pasquali; Régis Roche; Mario Maj; Uberto Pagotto; Palmiero Monteleone; Vincenzo Di Marzo
Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia.
The Journal of clinical endocrinology and metabolism 2006;91(8):3171-80.
2006: Giovanni Appendino; Alberto Minassi; Luca Berton; Aniello Schiano Moriello; Maria Grazia Cascio; Luciano De Petrocellis; Vincenzo Di Marzo
Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity.
Journal of medicinal chemistry 2006;49(7):2333-8.
2006: Nieves Márquez; Luciano De Petrocellis; Francisco J Caballero; Antonio Macho; Aniello Schiano Moriello; Alberto Minassi; Giovanni Appendino; Eduardo Muñoz; Vincenzo Di Marzo
Iodinated N-acylvanillamines: potential "multiple-target" anti-inflammatory agents acting via the inhibition of t-cell activation and antagonism at vanilloid TRPV1 channels.
Molecular pharmacology 2006;69(4):1373-82.
2006: Giovanni Appendino; Maria Grazia Cascio; Sara Bacchiega; Aniello Schiano Moriello; Alberto Minassi; Adèle Thomas; Ruth Ross; Roger Pertwee; Luciano De Petrocellis; Vincenzo Di Marzo
First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands.
FEBS letters 2006;580(2):568-74.
2006: Marina Piscopo; Luciano De Petrocellis; Mariachiara Conte; Giovanna Pulcrano; Giuseppe Geraci
On the possibility that H1 histone interaction with DNA occurs through phosphates connecting lysine and arginine side chain groups.
Acta biochimica Polonica 2006;53(3):507-13.
2006: Luigia Cristino; Luciano De Petrocellis; Gareth Pryce; D Baker; Vittorio Guglielmotti; Vincenzo Di Marzo
Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain.
Neuroscience 2006;139(4):1405-15.
2006: Alessia Ligresti; Maria Grazia Cascio; Gareth Pryce; Sanjitha Kulasegram; Irina P Beletskaya; Luciano De Petrocellis; Bijali Saha; Anu Mahadevan; Cristina Visintin; Jenny L Wiley; David Baker; Billy R Martin; Raj K Razdan; Vincenzo Di Marzo
New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis.
British journal of pharmacology 2006;147(1):83-91.
2005: Mario van der Stelt; Marcello Trevisani; Vittorio Vellani; Luciano De Petrocellis; Aniello Schiano Moriello; Barbara Campi; Peter A McNaughton; Pierangelo Geppetti; Vincenzo Di Marzo
Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels.
The EMBO journal 2005;24(17):3026-37.
2005: Luciano De Petrocellis; Vincenzo Di Marzo
Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels.
Life sciences 2005;77(14):1651-66.
2005: Giovanni Appendino; Nives Daddario; Alberto Minassi; Aniello Schiano Moriello; Luciano De Petrocellis; Vincenzo Di Marzo
The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination.
Journal of medicinal chemistry 2005;48(14):4663-9.
2005: Palmiero Monteleone; Isabel Matias; Vassilis Martiadis; Luciano De Petrocellis; Mario Maj; Vincenzo Di Marzo
Blood levels of the endocannabinoid anandamide are increased in anorexia nervosa and in binge-eating disorder, but not in bulimia nervosa.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(6):1216-21.
2005: Giovanni Appendino; Luciano De Petrocellis; Marcello Trevisani; Alberto Minassi; Nives Daddario; Aniello Schiano Moriello; David Gazzieri; Alessia Ligresti; Barbara Campi; Gabriele Fontana; Christian Pinna; Pierangelo Geppetti; Vincenzo Di Marzo
Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential.
The Journal of pharmacology and experimental therapeutics 2005;312(2):561-70.
2005: Vincenzo Di Marzo; Luciano De Petrocellis; Tiziana Bisogno
The biosynthesis, fate and pharmacological properties of endocannabinoids.
Handbook of experimental pharmacology 2005;(168):147-85.
2004: Vincenzo Di Marzo; Maurizio Bifulco; Luciano De Petrocellis
The endocannabinoid system and its therapeutic exploitation.
Nature reviews. Drug discovery 2004;3(9):771-84.
2004: Luciano De Petrocellis; Constance J Chu; Aniello Schiano Moriello; Juliane C Kellner; J Michael Walker; Vincenzo Di Marzo
Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels.
British journal of pharmacology 2004;143(2):251-6.
2004: Isabel Matias; June Chen; Luciano De Petrocellis; Tiziana Bisogno; Alessia Ligresti; Filomena Fezza; Achim H-P Krauss; L Shi; Charles E Protzman; Chen Li; Yanbin Liang; Amelia L Nieves; KM Kedzie; Robert M Burk; Vincenzo Di Marzo; David F Woodward
Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism.
The Journal of pharmacology and experimental therapeutics 2004;309(2):745-57.
2004: Luciano De Petrocellis; Maria Grazia Cascio; Vincenzo Di Marzo
The endocannabinoid system: a general view and latest additions.
British journal of pharmacology 2004;141(5):765-74.
2003: Giuseppe Portella; Chiara Laezza; Paolo Laccetti; Luciano De Petrocellis; Vincenzo Di Marzo; Maurizio Bifulco
Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(12):1771-3.
2003: Alessia Ligresti; Tiziana Bisogno; Isabel Matias; Luciano De Petrocellis; Maria Grazia Cascio; Vittorio Cosenza; Giuseppe d'Argenio; Giuseppe Scaglione; Maurizio Bifulco; Italo Sorrentini; Vincenzo Di Marzo
Possible endocannabinoid control of colorectal cancer growth.
Gastroenterology 2003;125(3):677-87.
2003: Nicola De Marchi; Luciano De Petrocellis; Pierangelo Orlando; Fabiana Daniele; Filomena Fezza; Vincenzo Di Marzo
Endocannabinoid signalling in the blood of patients with schizophrenia.
Lipids in health and disease 2003;2():5.
2003: Selena Harrison; Luciano De Petrocellis; Marcello Trevisani; Francesca Benvenuti; Maurizio Bifulco; Pierangelo Geppetti; Vincenzo Di Marzo
Capsaicin-like effects of N-arachidonoyl-dopamine in the isolated guinea pig bronchi and urinary bladder.
European journal of pharmacology 2003;475(1-3):107-14.
2003: Giovanni Appendino; Selena Harrison; Luciano De Petrocellis; Nives Daddario; Federica Bianchi; Aniello Schiano Moriello; Marcello Trevisani; Francesca Benvenuti; Pierangelo Geppetti; Vincenzo Di Marzo
Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists.
British journal of pharmacology 2003;139(8):1417-24.
2003: Giorgio Ortar; Alessia Ligresti; Luciano De Petrocellis; Enrico Morera; Vincenzo Di Marzo
Novel selective and metabolically stable inhibitors of anandamide cellular uptake.
Biochemical pharmacology 2003;65(9):1473-81.
2003: Constance J Chu; Susan M Huang; Luciano De Petrocellis; Tiziana Bisogno; Scott A Ewing; Jeffrey D Miller; Robert E Zipkin; Nives Daddario; Giovanni Appendino; Vincenzo Di Marzo; J Michael Walker
N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia.
The Journal of biological chemistry 2003;278(16):13633-9.
2003: Heike Hermann; Luciano De Petrocellis; Tiziana Bisogno; Aniello Schiano Moriello; Beat Lutz; Vincenzo Di Marzo
Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response.
Cellular and molecular life sciences : CMLS 2003;60(3):607-16.
2003: Isabel Lastres-Becker; Rosario De Miguel; Luciano De Petrocellis; Alexandros Makriyannis; Vincenzo Di Marzo; Javier Fernández-Ruiz
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease.
Journal of neurochemistry 2003;84(5):1097-109.
2003: Isabel Matias; Marion Léonhardt; J Lesage; Luciano De Petrocellis; Jean-Paul Dupouy; Didier Vieau; Vincenzo Di Marzo
Effect of maternal under-nutrition on pup body weight and hypothalamic endocannabinoid levels.
Cellular and molecular life sciences : CMLS 2003;60(2):382-9.
2003: Luciano De Petrocellis; Tiziana Bisogno; Vincenzo Di Marzo
Neuromodulatory actions neuromodulatory actions of endocannabinoids in pain and sedation.
Advances in experimental medicine and biology 2003;523():215-25.
2002: Giovanni Appendino; Alberto Minassi; Aniello Schiano Morello; Luciano De Petrocellis; Vincenzo Di Marzo
N-Acylvanillamides: development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor.
Journal of medicinal chemistry 2002;45(17):3739-45.
2002: Luciano De Petrocellis; Tiziana Bisogno; Alessia Ligresti; Maurizio Bifulco; Dominique Melck; Vincenzo Di Marzo
Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems.
Fundamental & clinical pharmacology 2002;16(4):297-302.
2002: Susan M Huang; Tiziana Bisogno; Marcello Trevisani; Abdulmonem Al-Hayani; Luciano De Petrocellis; Filomena Fezza; Michele Tognetto; Timothy J Petros; Jocelyn F Krey; Constance J Chu; Jeffrey D Miller; Stephen N Davies; Pierangelo Geppetti; J Michael Walker; Vincenzo Di Marzo
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8400-5.
2002: Vincenzo Di Marzo; Graeme Griffin; Luciano De Petrocellis; Ines Brandi; Tiziana Bisogno; William Williams; Mark C Grier; Sanjitha Kulasegram; Anu Mahadevan; Raj K Razdan; Billy R Martin
A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid.
The Journal of pharmacology and experimental therapeutics 2002;300(3):984-91.
2002: Vincenzo Di Marzo; Luciano De Petrocellis; Filomena Fezza; Alessia Ligresti; Tiziana Bisogno
Anandamide receptors.
Prostaglandins, leukotrienes, and essential fatty acids 2002;66(2-3):377-91.
2002: Dominique Melck; Tiziana Bisogno; Luciano De Petrocellis; Pierre Beaulieu; Andrew S C Rice; Vincenzo Di Marzo
Cannabimimetic eicosanoids in cancer and inflammation: an update.
Advances in experimental medicine and biology 2002;507():381-6.
2002: Tiziana Bisogno; Luciano De Petrocellis; Vincenzo Di Marzo
Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications.
Current pharmaceutical design 2002;8(7):533-47.
2001: Maurizio Bifulco; Chiara Laezza; Giuseppe Portella; M Vitale; Pierangelo Orlando; Luciano De Petrocellis; Vincenzo Di Marzo
Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(14):2745-7.
2001: Susan M Huang; Tiziana Bisogno; T J Petros; S Y Chang; P A Zavitsanos; Robert E Zipkin; R Sivakumar; Andrew Coop; Dean Y Maeda; Luciano De Petrocellis; Sumner H Burstein; Vincenzo Di Marzo; J Michael Walker
Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain.
The Journal of biological chemistry 2001;276(46):42639-44.
2001: Luciano De Petrocellis; John B Davis; Vincenzo Di Marzo
Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors.
FEBS letters 2001;506(3):253-6.
2001: Tiziana Bisogno; Lumír O Hanus; Luciano De Petrocellis; Susanna Tchilibon; Datta E Ponde; Ines Brandi; Aniello Schiano Moriello; John B Davis; Urij Rampampam; Vincenzo Di Marzo
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.
British journal of pharmacology 2001;134(4):845-52.
2001: Vincenzo Di Marzo; Dominique Melck; Pierangelo Orlando; Tiziana Bisogno; O Zagoory; Maurizio Bifulco; zvi vogel; Luciano De Petrocellis
Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells.
The Biochemical journal 2001;358(Pt 1):249-55.
2001: Vincenzo Di Marzo; Tiziana Bisogno; Luciano De Petrocellis
Anandamide: some like it hot.
Trends in pharmacological sciences 2001;22(7):346-9.
2001: Luciano De Petrocellis; Selena Harrison; Tiziana Bisogno; Michele Tognetto; Ines Brandi; G D Smith; Christophe Creminon; John B Davis; Pierangelo Geppetti; Vincenzo Di Marzo
The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase.
Journal of neurochemistry 2001;77(6):1660-3.
2001: Vincenzo Di Marzo; Isabel Lastres-Becker; Tiziana Bisogno; Luciano De Petrocellis; A Milone; John B Davis; Javier Fernandez-Ruiz
Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues.
European journal of pharmacology 2001;420(2-3):123-31.
2001: Luciano De Petrocellis; Tiziana Bisogno; Mauro Maccarrone; John B Davis; A Finazzi-Agro; Vincenzo Di Marzo
The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism.
The Journal of biological chemistry 2001;276(16):12856-63.
2001: Tiziana Bisogno; Mauro Maccarrone; Luciano De Petrocellis; A Jarrahian; A Finazzi-Agrò; C Hillard; Vincenzo Di Marzo
The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors.
European journal of biochemistry / FEBS 2001;268(7):1982-9.
2001: Vincenzo Di Marzo; Tiziana Bisogno; Luciano De Petrocellis; Ines Brandi; Reneé G Jefferson; Ramona Winckler; John B Davis; O Dasse; Anu Mahadevan; Raj K Razdan; Billy R Martin
Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor "hybrid" ligands.
Biochemical and biophysical research communications 2001;281(2):444-51.
2000: Tiziana Bisogno; Dominique Melck; Natalia Gretskaya; Vladimir V. Bezuglov; Luciano De Petrocellis; Vincenzo Di Marzo
N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo.
The Biochemical journal 2000;351 Pt 3():817-24.
2000: Luciano De Petrocellis; Tiziana Bisogno; John B Davis; R G Pertwee; Vincenzo Di Marzo
Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity.
FEBS letters 2000;483(1):52-6.
2000: Tiziana Bisogno; Luciano De Petrocellis
Endocannabinoids: new targets for drug development.
Current pharmaceutical design 2000;6(13):1361-80.
2000: Vincenzo Di Marzo; Maurizio Bifulco; Luciano De Petrocellis
Endocannabinoids and multiple sclerosis: a blessing from the 'inner bliss'?
Trends in pharmacological sciences 2000;21(6):195-7.
2000: Vincenzo Di Marzo; Dominique Melck; Luciano De Petrocellis; Tiziana Bisogno
Cannabimimetic fatty acid derivatives in cancer and inflammation.
Prostaglandins & other lipid mediators 2000;61(1-2):43-61.
2000: Dominique Melck; Luciano De Petrocellis; Pierangelo Orlando; Tiziana Bisogno; Chiara Laezza; Maurizio Bifulco; Vincenzo Di Marzo
Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation.
Endocrinology 2000;141(1):118-26.
1999: Dominique Melck; Daniel Rueda; Ismael Galve-Roperh; Luciano De Petrocellis; Manuel Guzmán; Vincenzo Di Marzo
Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells.
FEBS letters 1999;463(3):235-40.
1999: Dominique Melck; Tiziana Bisogno; Luciano De Petrocellis; H Chuang; David Julius; Maurizio Bifulco; Vincenzo Di Marzo
Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors.
Biochemical and biophysical research communications 1999;262(1):275-84.
1999: Vincenzo Di Marzo; Tiziana Bisogno; Luciano De Petrocellis; Dominique Melck; Billy R Martin
Cannabimimetic fatty acid derivatives: the anandamide family and other endocannabinoids.
Current medicinal chemistry 1999;6(8):721-44.
1999: Vincenzo Di Marzo; Tiziana Bisogno; Luciano De Petrocellis; Dominique Melck; Pierangelo Orlando; J A Wagner; George Kunos
Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages.
European journal of biochemistry / FEBS 1999;264(1):258-67.
1999: Tiziana Bisogno; Dominique Melck; Luciano De Petrocellis; Vincenzo Di Marzo
Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin.
Journal of neurochemistry 1999;72(5):2113-9.
1999: Nobuhiko Ueda; Kazuhisa Katayama; Yuko Kurahashi; M Suzuki; Hiroshi Suzuki; Shigeru Yamamoto; I Katoh; Vincenzo Di Marzo; Luciano De Petrocellis
Enzymological and molecular biological studies on anandamide amidohydrolase.
Advances in experimental medicine and biology 1999;469():513-8.
1999: Vincenzo Di Marzo; Luciano De Petrocellis; Tiziana Bisogno; Dominique Melck
Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments.
Lipids 1999;34 Suppl():S319-25.
1999: Luciano De Petrocellis; Dominique Melck; Tiziana Bisogno; A Milone; Vincenzo Di Marzo
Finding of the endocannabinoid signalling system in Hydra, a very primitive organism: possible role in the feeding response.
Neuroscience 1999;92(1):377-87.
1998: Vincenzo Di Marzo; N Sepe; Luciano De Petrocellis; A Berger; G Crozier; E Fride; Urij Rampampam
Trick or treat from food endocannabinoids?
Nature 1998;396(6712):636-7.
1998: Vincenzo Di Marzo; Dominique Melck; Tiziana Bisogno; Luciano De Petrocellis
Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action.
Trends in neurosciences 1998;21(12):521-8.
1998: Vincenzo Di Marzo; Tiziana Bisogno; Dominique Melck; R Ross; H Brockie; L Stevenson; R Pertwee; Luciano De Petrocellis
Interactions between synthetic vanilloids and the endogenous cannabinoid system.
FEBS letters 1998;436(3):449-54.
1998: Tiziana Bisogno; Dominique Melck; Luciano De Petrocellis; Natalia Gretskaya; Vladimir V. Bezuglov; Namthip Sitachitta; William H Gerwick; Vincenzo Di Marzo
Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase.
Biochemical and biophysical research communications 1998;248(3):515-22.
1998: Tiziana Bisogno; K Katayama; Dominique Melck; N Ueda; Luciano De Petrocellis; S Yamamoto; Vincenzo Di Marzo
Biosynthesis and degradation of bioactive fatty acid amides in human breast cancer and rat pheochromocytoma cells--implications for cell proliferation and differentiation.
European journal of biochemistry / FEBS 1998;254(3):634-42.
1998: Vincenzo Di Marzo; Tiziana Bisogno; T Sugiura; Dominique Melck; Luciano De Petrocellis
The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: connections with anandamide.
The Biochemical journal 1998;331 ( Pt 1)():15-9.
1998: N Sepe; Luciano De Petrocellis; F Montanaro; Guido Cimino; Vincenzo Di Marzo
Bioactive long chain N-acylethanolamines in five species of edible bivalve molluscs. Possible implications for mollusc physiology and sea food industry.
Biochimica et biophysica acta 1998;1389(2):101-11.
1997: Tiziana Bisogno; N Sepe; Luciano De Petrocellis; R Mechoulam; Vincenzo Di Marzo
The sleep inducing factor oleamide is produced by mouse neuroblastoma cells.
Biochemical and biophysical research communications 1997;239(2):473-9.
1997: Tiziana Bisogno; N Sepe; Dominique Melck; S Maurelli; Luciano De Petrocellis; Vincenzo Di Marzo
Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells.
The Biochemical journal 1997;322 ( Pt 2)():671-7.
1997: Tiziana Bisogno; S Maurelli; Dominique Melck; Luciano De Petrocellis; Vincenzo Di Marzo
Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes.
The Journal of biological chemistry 1997;272(6):3315-23.
1997: Luciano De Petrocellis; Dominique Melck; Nobuhiko Ueda; S Maurelli; Yuko Kurahashi; Shigeru Yamamoto; G Marino; Vincenzo Di Marzo
Novel inhibitors of brain, neuronal, and basophilic anandamide amidohydrolase.
Biochemical and biophysical research communications 1997;231(1):82-8.
1997: Luciano De Petrocellis; Dominique Melck; Nobuhiko Ueda; Yuko Kurahashi; T Bisogno; Shigeru Yamamoto; Vincenzo Di Marzo
Brain and peripheral anandamide amidohydrolase and its inhibition by synthetic arachidonate analogues.
Advances in experimental medicine and biology 1997;433():259-63.
1997: Tiziana Bisogno; N Sepe; Luciano De Petrocellis; Vincenzo Di Marzo
Biosynthesis of 2-arachidonoyl-glycerol, a novel cannabimimetic eicosanoid, in mouse neuroblastoma cells.
Advances in experimental medicine and biology 1997;433():201-4.
1997: Vincenzo Di Marzo; Luciano De Petrocellis; Tiziana Bisogno; S Maurelli
The endogenous cannabimimetic eicosanoid, anandamide, induces arachidonate release in J774 mouse macrophages.
Advances in experimental medicine and biology 1997;407():341-6.
1996: Vincenzo Di Marzo; Luciano De Petrocellis; T Sugiura; K Waku
Potential biosynthetic connections between the two cannabimimetic eicosanoids, anandamide and 2-arachidonoyl-glycerol, in mouse neuroblastoma cells.
Biochemical and biophysical research communications 1996;227(1):281-8.
1996: Luciano De Petrocellis; P Orlando; M Gavagnin; M Ventriglia; Guido Cimino; Vincenzo Di Marzo
Novel diterpenoid diacylglycerols from marine molluscs: potent morphogens and protein kinase C activators.
Experientia 1996;52(9):874-7.
1996: Vincenzo Di Marzo; Luciano De Petrocellis; N Sepe; A Buono
Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells.
The Biochemical journal 1996;316 ( Pt 3)():977-84.
1995: S Maurelli; Tiziana Bisogno; Luciano De Petrocellis; A Di Luccia; Gennaro Marino; Vincenzo Di Marzo
Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma 'anandamide amidohydrolase'.
FEBS letters 1995;377(1):82-6.
1995: Luciano De Petrocellis; P Orlando; Vincenzo Di Marzo
Anandamide, an endogenous cannabinomimetic substance, modulates rat brain protein kinase C in vitro.
Biochemistry and molecular biology international 1995;36(6):1127-33.
1994: Vincenzo Di Marzo; C Gianfrani; Luciano De Petrocellis; A Milone; Guido Cimino
Polyunsaturated-fatty-acid oxidation in Hydra: regioselectivity, substrate-dependent enantioselectivity and possible biological role.
The Biochemical journal 1994;300 ( Pt 2)():501-7.
1993: M Piscopo; L Tomei; Luciano De Petrocellis; Giuseppe Geraci
Anion-mediated lysine-arginine interaction. Evidence in Chaetopterus variopedatus sperm protamine.
FEBS letters 1993;334(1):125-7.
1993: Vincenzo Di Marzo; Luciano De Petrocellis; C Gianfrani; Guido Cimino
Biosynthesis, structure and biological activity of hydroxyeicosatetraenoic acids in Hydra vulgaris.
The Biochemical journal 1993;295 ( Pt 1)():23-9.
1991: Luciano De Petrocellis; Vincenzo Di Marzo; B Arcà; M Gavagnin; Rosario Minei; Guido Cimino
The effect of diterpenoidic diacylglycerols on tentacle regeneration in Hydra vulgaris.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 1991;100(3):603-7.
1986: Luciano De Petrocellis; G Quagliarotti; L Tomei; Giuseppe Geraci
Structuring of H1 histone. Evidence of high-affinity binding sites for phosphate ions.
European journal of biochemistry / FEBS 1986;156(1):143-8.
1986: Luciano De Petrocellis; V Senthil Maharajan; B De Petrocellis; Rosario Minei
Bud induction in decapitated Hydra attenuata by 5-azacytidine: a morphological study.
Journal of embryology and experimental morphology 1986;93():105-19.
1980: B de Petrocellis; Luciano De Petrocellis; M Lancieri; Giuseppe Geraci
Species specificity and individual variability of sea urchin sperm H2B histones.
Cell differentiation 1980;9(4):195-202.