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Johan de Rooij

Research Profile

Chemicals & Drugs

Physiology

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

TOP 3
Emma Spanjaard; Johan de Rooij
Mechanotransduction: vinculin provides stability when tension rises.
Stephan Huveneers; Johan de Rooij
Mechanosensitive systems at the cadherin-F-actin interface.
Floor Twiss; Suzanne Van Der Horst; Gerard Van Der Krogt; Ning Wang; Stephan Huveneers; Quint Le Duc; Deborah E Leckband; Holger Rehmann; Hamid Tabdili; Johan de Rooij
Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation.

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All Publications

2013: Emma Spanjaard; Johan de Rooij
Mechanotransduction: vinculin provides stability when tension rises.
Current biology : CB 2013;23(4):R159-61.
2013: Stephan Huveneers; Johan de Rooij
Mechanosensitive systems at the cadherin-F-actin interface.
Journal of cell science 2013;126(Pt 2):403-13.
2012: Floor Twiss; Suzanne Van Der Horst; Gerard Van Der Krogt; Ning Wang; Stephan Huveneers; Quint Le Duc; Deborah E Leckband; Holger Rehmann; Hamid Tabdili; Johan de Rooij
Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation.
Biology open 2012;1(11):1128-40.
2012: Dinah Loerke; matthias machacek; Emma Spanjaard; Iris Blonk; Gaudenz Danuser; Andre Kerstens; Quint le Duc; Johan de Rooij
Quantitative imaging of epithelial cell scattering identifies specific inhibitors of cell motility and cell-cell dissociation.
Science signaling 2012;5(231):rs5.
2012: Stephan Huveneers; Joppe Oldenburg; Holger Rehmann; Emma Spanjaard; Gerard van der Krogt; Anna Akhmanova; Ilya Grigoriev; Johan de Rooij
Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling.
The Journal of cell biology 2012;196(5):641-52.
2012: Sarah H Ross; Emma Spanjaard; Marjolein J Vliem; Johannes L Bos; Hendy Kristyanto; Anneke Post; Johan de Rooij
Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation.
PloS one 2012;7(11):e50072.
2011: Willem-Jan Pannekoek; Holger Rehmann; Emma Spanjaard; Anne Jan van der Meer; Jantine J G van Dijk; Fried J T Zwartkruis; Patricia M Brouwer; On Ying A Chan; Johan de Rooij; Stephan Huveneers; Jelena R Linnemann; Johannes L Bos
Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.
Cellular signalling 2011;23(12):2056-64.
2011: Deborah E Leckband; Ning Wang; Quint le Duc; Johan de Rooij
Mechanotransduction at cadherin-mediated adhesions.
Current opinion in cell biology 2011;23(5):523-30.
2010: Quint le Duc; Quanming Shi; Iris Blonk; Arnoud Sonnenberg; Ning Wang; Deborah Leckband; Johan de Rooij
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner.
The Journal of cell biology 2010;189(7):1107-15.
2005: Wendy Pellis-van Berkel; M H G Verheijen; Edwin Cuppen; M Asahina; Johan de Rooij; G Jansen; Ronald H Plasterk; Johannes L Bos; Fried J T Zwartkruis
Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity.
Molecular biology of the cell 2005;16(1):106-16.
2003: Anne E Christensen; Frode Selheim; Johan de Rooij; Sarah Dremier; Frank Schwede; Khanh K Dao; Aurora Martinez; Carine Maenhaut; Johannes L Bos; Hans-Gottfried Genieser; Stein Ove Døskeland
cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension.
The Journal of biological chemistry 2003;278(37):35394-402.
2003: Kim M T de Bruyn; Fried J T Zwartkruis; Johan de Rooij; Jan-Willem N Akkerman; Johannes L Bos
The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes.
The Journal of biological chemistry 2003;278(25):22412-7.
2003: H Bea Kuiperij; Johan de Rooij; Holger Rehmann; Miranda van Triest; Alfred Wittinghofer; Johannes L Bos; Fried J T Zwartkruis
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.
Biochimica et biophysica acta 2003;1593(2-3):141-9.
2003: Savithri Rangarajan; Jorrit M Enserink; H Bea Kuiperij; Johan de Rooij; Leo S Price; Frank Schwede; Johannes L Bos
Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor.
The Journal of cell biology 2003;160(4):487-93.
2003: Johannes L Bos; Kim M T de Bruyn; Jorrit M Enserink; B Kuiperij; Savithri Rangarajan; Holger Rehmann; Jurgen Riedl; Johan de Rooij; F van Mansfeld; Fried J T Zwartkruis
The role of Rap1 in integrin-mediated cell adhesion.
Biochemical Society transactions 2003;31(Pt 1):83-6.
2003: Holger Rehmann; Balaji Prakash; Eva Wolf; Alma Rueppel; Johan de Rooij; Johannes L Bos; Alfred Wittinghofer
Structure and regulation of the cAMP-binding domains of Epac2.
Nature structural biology 2003;10(1):26-32.
2002: Jorrit M Enserink; Anne E Christensen; Johan de Rooij; Miranda van Triest; Frank Schwede; Hans-Gottfried Genieser; Stein Ove Døskeland; Jonathan L Blank; Johannes L Bos
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.
Nature cell biology 2002;4(11):901-6.
2001: Johannes L Bos; Johan de Rooij; Kris A Reedquist
Rap1 signalling: adhering to new models.
Nature reviews. Molecular cell biology 2001;2(5):369-77.
2001: A Kraemer; Holger Rehmann; Robbert Cool; C Theiss; Johan de Rooij; Johannes L Bos; Alfred Wittinghofer
Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1.
Journal of molecular biology 2001;306(5):1167-77.
2001: Miranda van Triest; Johan de Rooij; Johannes L Bos
Measurement of GTP-bound Ras-like GTPases by activation-specific probes.
Methods in enzymology 2001;333():343-8.
2000: Kim M T de Bruyn; Johan de Rooij; RM Wolthuis; Holger Rehmann; J Wesenbeek; Robbert Cool; Alfred Wittinghofer; Johannes L Bos
RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral.
The Journal of biological chemistry 2000;275(38):29761-6.
2000: Johan de Rooij; Holger Rehmann; Miranda van Triest; Robbert Cool; Alfred Wittinghofer; Johannes L Bos
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.
The Journal of biological chemistry 2000;275(27):20829-36.
1999: Johan de Rooij; N M Boenink; Miranda van Triest; Robbert Cool; Alfred Wittinghofer; Johannes L Bos
PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2.
The Journal of biological chemistry 1999;274(53):38125-30.
1998: Johan de Rooij; Fried J T Zwartkruis; M H G Verheijen; Robbert Cool; S M Nijman; Alfred Wittinghofer; Johannes L Bos
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.
Nature 1998;396(6710):474-7.
1998: DH van Weering; Johan de Rooij; B Marte; J Downward; Johannes L Bos; Boudewijn M T Burgering
Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.
Molecular and cellular biology 1998;18(4):1802-11.
1997: Johan de Rooij; Johannes L Bos
Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.
Oncogene 1997;14(5):623-5.