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Frederic de Sauvage

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TOP 3
Ciara Metcalfe; Frederic J de Sauvage
A tumor-specific stem cell.
Somasekar Seshagiri; Timothy K Starr; Eric W Stawiski; Jeremy Stinson; Elaine E Storm; Weiru Wang; Thomas D Wu; Zemin Zhang; Jeremiah D Degenhardt; Gerrit J P Dijkgraaf; Steffen Durinck; Robert Gentleman; Florian Gnad; Yinghui Guan; Joseph Guillory; Connie Ha; Peter M Haverty; Melanie A Huntley; Bijay S Jaiswal; Vasantharajan Janakiraman; Hartmut Koeppen; David A Largaespada; Zora Modrusan; Richard Bourgon; Subhra Chaudhuri; Caitlin B Conboy; Frederic J de Sauvage
Recurrent R-spondin fusions in colon cancer.
Zhaoshi Jiang; Stephanie Johnson; Adrian M Jubb; Sharookh B Kapadia; Michael I Kennemer; William Lee; Jinfeng Liu; Zora Modrusan; Krishna P Pant; Somasekar Seshagiri; Howard M Stern; Jeremy Stinson; Thomas D Wu; Weilan Ye; Stacy Yeung; Dennis G Ballinger; Paolo Carnevali; Frederic J de Sauvage; Jingyu Diao; Robert C Gentleman; Yinghui Guan; Peter M Haverty; Suchit Jhunjhunwala; Zemin Zhang
The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.

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All Publications

2013: Ciara Metcalfe; Frederic J de Sauvage
A tumor-specific stem cell.
Nature genetics 2013;45(1):7-9.
2012: Somasekar Seshagiri; Timothy K Starr; Eric W Stawiski; Jeremy Stinson; Elaine E Storm; Weiru Wang; Thomas D Wu; Zemin Zhang; Jeremiah D Degenhardt; Gerrit J P Dijkgraaf; Steffen Durinck; Robert Gentleman; Florian Gnad; Yinghui Guan; Joseph Guillory; Connie Ha; Peter M Haverty; Melanie A Huntley; Bijay S Jaiswal; Vasantharajan Janakiraman; Hartmut Koeppen; David A Largaespada; Zora Modrusan; Richard Bourgon; Subhra Chaudhuri; Caitlin B Conboy; Frederic J de Sauvage
Recurrent R-spondin fusions in colon cancer.
Nature 2012;488(7413):660-4.
2012: Zhaoshi Jiang; Stephanie Johnson; Adrian M Jubb; Sharookh B Kapadia; Michael I Kennemer; William Lee; Jinfeng Liu; Zora Modrusan; Krishna P Pant; Somasekar Seshagiri; Howard M Stern; Jeremy Stinson; Thomas D Wu; Weilan Ye; Stacy Yeung; Dennis G Ballinger; Paolo Carnevali; Frederic J de Sauvage; Jingyu Diao; Robert C Gentleman; Yinghui Guan; Peter M Haverty; Suchit Jhunjhunwala; Zemin Zhang
The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.
Genome research 2012;22(4):593-601.
2012: Hayley J Sharpe; Frederic J de Sauvage
Signaling: An oxysterol ligand for Smoothened.
Nature chemical biology 2012;8(2):139-40.
2012: Rebecca J Brais; Sian Chilcott; Natalie Cook; Pippa G Corrie; Walter C Darbonne; Susan E Davies; Frederic J de Sauvage; Emmanuel Huguet; Asif Jah; Neville V Jamieson; Duncan I Jodrell; Michelle Lockley; Martijn Lolkema; Albrecht Neesse; Maria O'Donovan; Raaj K Praseedom; Ben W Simpson; David A Tuveson; Nicholas R Carroll
Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2012;12(1):8-15.
2011: Hua Tian; Søren Warming; Brian Biehs; Ophir D Klein; Kevin G Leong; Linda Rangell; Frederic J de Sauvage
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable.
Nature 2011;478(7368):255-9.
2011: Susanna Stinson; Søren Warming; Ru-Fang Yeh; Nancy Yu; Peng Yue; Alex T Adai; Lukas C Amler; Richard Bourgon; Zachary Boyd; Frederic J de Sauvage; Thomas Januario; Suchit Jhunjhunwala; Hyo-Jin Kim; Mark R Lackner; Zora Modrusan; Robert J Newman; Carol O'Brien; Jill Spoerke; Howard M Stern; David Dornan
miR-221/222 targeting of trichorhinophalangeal 1 (TRPS1) promotes epithelial-to-mesenchymal transition in breast cancer.
Science signaling 2011;4(186):pt5.
2011: Harvey Wong; Robert L Yauch; Bruno Alicke; Frederic J de Sauvage; Thomas Januario; Hank La; Patricia Pacheco; Kristina A West; Stephen E Gould
Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(14):4682-92.
2011: Weiwei Chen; Walter C Darbonne; Frederic J de Sauvage; Debra Dunlap; Kelly J DuPree; Jeff Eastham-Anderson; Stephen Gould; Zora Modrusan; Michelle Nannini; Greg Plowman; Tracy Tang; Robert Yauch; Bruno Alicke; Christopher A Callahan
Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(23):9589-94.
2011: Tracy Tang; Jean Y Tang; Dongwei Li; Mike Reich; Christopher A Callahan; Ling Fu; Robert L Yauch; Frank Wang; Karen Kotkow; Kris S Chang; Elana Shpall; Angela Wu; Lee L Rubin; James C Marsters; Ervin H Epstein; Ivor Caro; Frederic J de Sauvage
Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(10):3378-87.
2011: Gerrit J P Dijkgraaf; Bruno Alicke; Lasse Weinmann; Thomas Januario; Kristina West; Zora Modrusan; Dan Burdick; Richard Goldsmith; Kirk Robarge; Dan Sutherlin; Suzie J Scales; Stephen E Gould; Robert L Yauch; Frederic J de Sauvage
Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance.
Cancer research 2011;71(2):435-44.
2011: Susanna Stinson; Søren Warming; Ru-Fang Yeh; Nancy Yu; Peng Yue; Alex T Adai; Lukas Amler; Richard Bourgon; Zachary Boyd; Frederic J de Sauvage; Thomas Januario; Suchit Jhunjhunwala; Hyo-Jin Kim; Mark R Lackner; Zora Modrusan; Robert J Newman; Carol O'Brien; Jill Spoerke; Howard M Stern; David Dornan
TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer.
Science signaling 2011;4(177):ra41.
2011: Kui Lin; James R Taylor; Thomas D Wu; Johnny Gutierrez; J Michael Elliott; Jean-Michel Vernes; Hartmut Koeppen; Heidi S Phillips; Frederic J de Sauvage; Y Gloria Meng
TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma.
PloS one 2011;6(4):e18608.
2010: Marcel Batten; Nandhini Ramamoorthi; Noelyn M Kljavin; Cindy S Ma; Jennifer H Cox; Hart S Dengler; Dimitry M Danilenko; Patrick Caplazi; Melanie Wong; David A Fulcher; Matthew C Cook; Cecile King; Stuart G Tangye; Frederic J de Sauvage; Nico Ghilardi
IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells.
The Journal of experimental medicine 2010;207(13):2895-906.
2010: Jennifer A Low; Frederic J de Sauvage
Clinical experience with Hedgehog pathway inhibitors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(36):5321-6.
2010: Georgette M Castanedo; Shumei Wang; Kirk D Robarge; Elizabeth Blackwood; Daniel Burdick; Christine Chang; Gerrit J P Dijkgraaf; Stephen Gould; Janet Gunzner; Oivin Guichert; Jason Halladay; Cyrus Khojasteh; Leslie Lee; James C Marsters; Lesley Murray; David Peterson; Emile Plise; Laurent Salphati; Frederic J de Sauvage; Susan Wong; Daniel P Sutherlin
Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway.
Bioorganic & medicinal chemistry letters 2010;20(22):6748-53.
2010: Kerstin Seidel; Christina P Ahn; David Lyons; Alexander Nee; Kevin Ting; Isaac Brownell; Tim Cao; Richard A D Carano; Tom Curran; Markus Schober; Elaine Fuchs; Alexandra L Joyner; Gail R Martin; Frederic J de Sauvage; Ophir D Klein
Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.
Development (Cambridge, England) 2010;137(22):3753-61.
2010: Henry R Maun; Xiaohui Wen; Andreas Lingel; Frederic J de Sauvage; Robert A Lazarus; Suzie J Scales; Sarah G Hymowitz
Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.
The Journal of biological chemistry 2010;285(34):26570-80.
2010: Jeremy F Reiter; Frederic J de Sauvage
Vive la science! Vive le hérisson!
EMBO reports 2010;11(8):566-8.
2010: Tracy Tang; Li Li; Jerry Tang; Yun Li; Wei Yu Lin; Flavius Martin; Deanna Grant; Mark Solloway; Leon Parker; Weilan Ye; William Forrest; Nico Ghilardi; Tamas Oravecz; Kenneth A Platt; Dennis S Rice; Gwenn M Hansen; Alejandro Abuin; Derek E Eberhart; Paul Godowski; Kathleen H Holt; Andrew Peterson; Brian P Zambrowicz; Frederic J de Sauvage
A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology 2010;28(7):749-55.
2010: William Lee; Zhaoshi Jiang; Jinfeng Liu; Peter M Haverty; Yinghui Guan; Jeremy Stinson; Peng Yue; Yan Zhang; Krishna P Pant; Deepali Bhatt; Connie Ha; Stephanie Johnson; Michael I Kennemer; Sankar Mohan; Igor Nazarenko; Colin Watanabe; Andrew B Sparks; David S Shames; Robert Gentleman; Frederic J de Sauvage; Howard Stern; Ajay Pandita; Dennis G Ballinger; Radoje Drmanac; Zora Modrusan; Somasekar Seshagiri; Zemin Zhang
The mutation spectrum revealed by paired genome sequences from a lung cancer patient.
Nature 2010;465(7297):473-7.
2010: Xiaohui Wen; Cary K Lai; Marie Evangelista; Jo-Anne Hongo; Frederic J de Sauvage; Suzie J Scales
Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation.
Molecular and cellular biology 2010;30(8):1910-22.
2009: Bijay S Jaiswal; Vasantharajan Janakiraman; Noelyn M Kljavin; Subhra Chaudhuri; Howard M Stern; Weiru Wang; Zhengyan Kan; Hashem Dbouk; Brock A Peters; Paul Waring; Trisha Dela Vega; Denise M Kenski; Krista K Bowman; Maria Lorenzo; Hong Li; Jiansheng Wu; Zora Modrusan; Jeremy Stinson; Michael Eby; Peng Yue; Josh S Kaminker; Frederic J de Sauvage; Jonathan M Backer; Somasekar Seshagiri
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.
Cancer cell 2009;16(6):463-74.
2009: Robert L Yauch; Gerrit J P Dijkgraaf; Bruno Alicke; Thomas Januario; Christina P Ahn; THOMAS HOLCOMB; Kanan Pujara; Jeremy Stinson; Christopher A Callahan; Tracy Tang; J Fernando Bazan; Zhengyan Kan; Somasekar Seshagiri; CHRISTINE HANN; Stephen E Gould; Jennifer A Low; Charles Rudin; Frederic J de Sauvage
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
Science (New York, N.Y.) 2009;326(5952):572-4.
2009: J Fernando Bazan; Frederic J de Sauvage
Structural ties between cholesterol transport and morphogen signaling.
Cell 2009;138(6):1055-6.
2009: Daniel Von Hoff; Patricia M LoRusso; Charles Rudin; Josina C Reddy; Robert L Yauch; Raoul Tibes; Glen J Weiss; Mitesh J Borad; CHRISTINE HANN; Julie R Brahmer; Howard M Mackey; Bertram L Lum; Walter C Darbonne; James C Marsters; Frederic J de Sauvage; Jennifer A Low
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.
The New England journal of medicine 2009;361(12):1164-72.
2009: Charles Rudin; CHRISTINE HANN; John Laterra; Robert L Yauch; Christopher A Callahan; Ling Fu; THOMAS HOLCOMB; Jeremy Stinson; Stephen E Gould; Barbara Coleman; Patricia M LoRusso; Daniel Von Hoff; Frederic J de Sauvage; Jennifer A Low
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.
The New England journal of medicine 2009;361(12):1173-8.
2009: Setsu Endoh-Yamagami; Marie Evangelista; Deanna Wilson; Xiaohui Wen; Jan-Willem Theunissen; Khanhky Phamluong; Matti Davis; Suzie J Scales; Mark J Solloway; Frederic J de Sauvage; Andrew S Peterson
The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.
Current biology : CB 2009;19(15):1320-6.
2009: Jan-Willem Theunissen; Frederic J de Sauvage
Paracrine Hedgehog signaling in cancer.
Cancer research 2009;69(15):6007-10.
2009: Ching Ching Leow; Bu-Er Wang; Jed Ross; Sara M Chan; Jiping Zha; Richard A D Carano; Gretchen Frantz; Michael M Shen; Frederic J de Sauvage; Wei-Qiang Gao
Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway.
The Journal of biological chemistry 2009;284(31):21057-65.
2009: Ivan Bosanac; Henry R Maun; Suzie J Scales; Xiaohui Wen; Andreas Lingel; J Fernando Bazan; Frederic J de Sauvage; Sarah G Hymowitz; Robert A Lazarus
The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.
Nature structural & molecular biology 2009;16(7):691-7.
2009: Inga Hofmann; Elizabeth H Stover; Dana E Cullen; Junhao Mao; Kelly J Morgan; Benjamin H Lee; Michael G Kharas; Peter G Miller; Melanie G Cornejo; Rachel Okabe; Scott A Armstrong; Nico Ghilardi; Stephen Gould; Frederic J de Sauvage; Andrew P McMahon; D Gary Gilliland
Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis.
Cell stem cell 2009;4(6):559-67.
2009: Suzie J Scales; Frederic J de Sauvage
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.
Trends in pharmacological sciences 2009;30(6):303-12.
2009: Hua Tian; Christopher A Callahan; Kelly J DuPree; Walter C Darbonne; Christina P Ahn; Suzie J Scales; Frederic J de Sauvage
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(11):4254-9.
2009: Andrew G Polson; Jill Calemine-Fenaux; Pamela Chan; Wesley Chang; Erin Christensen; Suzanna Clark; Frederic J de Sauvage; Dan Eaton; Kristi Elkins; J Michael Elliott; Gretchen Frantz; Reina N Fuji; Alane Gray; Kristin Harden; Gladys S Ingle; Noelyn M Kljavin; Hartmut Koeppen; Christopher Nelson; Saileta Prabhu; Helga Raab; Sarajane Ross; Dion S Slaga; Jean-Philippe Stephan; Suzie J Scales; Susan D Spencer; Richard Vandlen; Bernd Wranik; Shang-Fan Yu; Bing Zheng; Allen Ebens
Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection.
Cancer research 2009;69(6):2358-64.
2009: Ralph Tiedt; Jörn Coers; Sandra Ziegler; Adrian Wiestner; Hui Hao-Shen; Caroline Bornmann; Johannes Schenkel; Svetlana Karakhanova; Frederic J de Sauvage; Carl W Jackson; Radek C Skoda
Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes.
Blood 2009;113(8):1768-77.
2008: Robert L Yauch; Stephen E Gould; Suzie J Scales; Tracy Tang; Hua Tian; Christina P Ahn; Derek Marshall; Ling Fu; Thomas Januario; Dara Kallop; Michelle Nannini-Pepe; Karen Kotkow; James C Marsters; Lee L Rubin; Frederic J de Sauvage
A paracrine requirement for hedgehog signalling in cancer.
Nature 2008;455(7211):406-10.
2008: Marcel Batten; Noelyn M Kljavin; Ji Li; Michael J Walter; Frederic J de Sauvage; Nico Ghilardi
Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):2752-6.
2008: Yan Zheng; Patricia A Valdez; Dimitry M Danilenko; Yan Hu; Susan M Sa; Qian Gong; Alex Abbas; Zora Modrusan; Nico Ghilardi; Frederic J de Sauvage; Wenjun Ouyang
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens.
Nature medicine 2008;14(3):282-9.
2008: Marie Evangelista; Tze Yang Lim; James Lee; Leon Parker; Amir Ashique; Andrew S Peterson; Weilan Ye; David P Davis; Frederic J de Sauvage
Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction.
Science signaling 2008;1(39):ra7.
2007: Brock A Peters; Zhengyan Kan; Dragan Sebisanovic; Kanan Pujara; Zhiyong Wang; Peter Hong; Bernard Chow; Jeremy Stinson; Victoria E H Carlton; Thinh Q Pham; Howard M Stern; Paul Waring; Kenneth J Hillan; David A Eberhard; Frederic J de Sauvage; Jianbiao Zheng; Malek Faham; Somasekar Seshagiri
Highly efficient somatic-mutation identification using Escherichia coli mismatch-repair detection.
Nature methods 2007;4(9):713-5.
2007: Anne P Beigneux; Brandon S J Davies; Peter Gin; Michael M Weinstein; Emily A Farber; Xin Qiao; Franklin Peale; Stuart Bunting; Rosemary Walzem; Jinny S Wong; William S Blaner; Zhi-Ming Ding; Kristan Melford; Nuttaporn Wongsiriroj; Xiao Shu; Frederic J de Sauvage; Robert O Ryan; Loren G Fong; André Bensadoun; Stephen G Young
Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons.
Cell metabolism 2007;5(4):279-91.
2007: Hal E Broxmeyer; Ji Li; Giao Hangoc; Scott Cooper; Wen Tao; Charlie Mantel; Barbara Graham-Evans; Nico Ghilardi; Frederic J de Sauvage
Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31.
Experimental hematology 2007;35(4 Suppl 1):78-86.
2007: Jacqueline G Perrigoue; Ji Li; Colby Zaph; Michael H Goldschmidt; Phillip Scott; Frederic J de Sauvage; Edward J Pearce; Nico Ghilardi; David Artis
IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung.
The Journal of experimental medicine 2007;204(3):481-7.
2006: John Ridgway; Gu Zhang; Yan Wu; Scott Stawicki; Wei-Ching Liang; Yvan Chanthery; Joe Kowalski; Ryan J Watts; Christopher Callahan; Ian Kasman; Mallika Singh; May Chien; Christine Tan; Jo-Anne S Hongo; Frederic J de Sauvage; Greg Plowman; Minhong Yan
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis.
Nature 2006;444(7122):1083-7.
2006: Lee L Rubin; Frederic J de Sauvage
Targeting the Hedgehog pathway in cancer.
Nature reviews. Drug discovery 2006;5(12):1026-33.
2006: Marie Evangelista; Hua Tian; Frederic J de Sauvage
The hedgehog signaling pathway in cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(20 Pt 1):5924-8.
2006: Scott McCallum; J. Fernando Bazan; Mark Merchant; JianPing Yin; Borlan Pan; Frederic J de Sauvage; Wayne J Fairbrother
Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly.
Biochemistry 2006;45(39):11974-82.
2006: Marcel Batten; Ji Li; Sothy Yi; Noelyn M Kljavin; Dimitry M Danilenko; Sophie Lucas; James Lee; Frederic J de Sauvage; Nico Ghilardi
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells.
Nature immunology 2006;7(9):929-36.
2006: Xi-De Wang; Ching Ching Leow; Jiping Zha; Zhijun Tang; Zora Modrusan; Freddy Radtke; Michel Aguet; Frederic J de Sauvage; Wei-Qiang Gao
Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation.
Developmental biology 2006;290(1):66-80.
2006: Lucia E Rosas; Anjali A Satoskar; Kimberly M Roth; Tracy Keiser; Joseph Barbi; Christopher Hunter; Frederic J de Sauvage; Abhay R Satoskar
Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology.
The American journal of pathology 2006;168(1):158-69.
2006: Alejandro V Villarino; Jason S Stumhofer; Christiaan J M Saris; Robert A Kastelein; Frederic J de Sauvage; Christopher A Hunter
IL-27 limits IL-2 production during Th1 differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):237-47.
2005: Daniel Gray; Adrian M Jubb; Deborah Hogue; Patrick Dowd; Noelyn M Kljavin; Sothy Yi; Wei Bai; Gretchen D Frantz; Zemin Zhang; Hartmut Koeppen; Frederic J de Sauvage; David P Davis
Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers.
Cancer research 2005;65(21):9751-61.
2005: Mark Merchant; Marie Evangelista; Shiuh-Ming Luoh; Gretchen D Frantz; Sreedevi Chalasani; Richard A D Carano; Marjie van Hoy; Julio Ramirez; Annie K Ogasawara; Leanne M McFarland; Ellen H Filvaroff; Dorothy M French; Frederic J de Sauvage
Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus.
Molecular and cellular biology 2005;25(16):7054-68.
2005: Alejandro V Villarino; Joseph Larkin; Christiaan J M Saris; Andrew J Caton; Sophie Lucas; Terence Wong; Frederic J de Sauvage; Christopher A Hunter
Positive and negative regulation of the IL-27 receptor during lymphoid cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7684-91.
2005: Sarah E Craven; Dorothy French; Weilan Ye; Frederic J de Sauvage; Arnon Rosenthal
Loss of Hspa9b in zebrafish recapitulates the ineffective hematopoiesis of the myelodysplastic syndrome.
Blood 2005;105(9):3528-34.
2005: Hal E Broxmeyer; Scott Cooper; Laurence A Lasky; Frederic J de Sauvage
Identification of a massive reserve of hematopoietic progenitors in mice.
Stem cells and development 2005;14(2):105-10.
2004: Wei Chen; Xiu-Rong Ren; Christopher D Nelson; Larry S Barak; James Kenneth Chen; Philip A Beachy; Frederic J de Sauvage; Robert J Lefkowitz
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.
Science (New York, N.Y.) 2004;306(5705):2257-60.
2004: David Artis; Alejandro V Villarino; Michael Silverman; Weimian He; Elisabeth M Thornton; Sharon Mu; Shamin Summer; Todd M Covey; Elaine Huang; Hiroki Yoshida; Gary A Koretzky; Michael H Goldschmidt; Gary D Wu; Frederic J de Sauvage; Hugh Miller; Christiaan J M Saris; Phillip Scott; Christopher A Hunter
The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5626-34.
2004: Mark Merchant; Felix F Vajdos; Mark Ultsch; Henry R Maun; K. Ulrich wendt; Jennifer Cannon; Bill Desmarais; Robert A Lazarus; Abraham M de Vos; Frederic J de Sauvage
Suppressor of fused regulates Gli activity through a dual binding mechanism.
Molecular and cellular biology 2004;24(19):8627-41.
2004: Leon H Parker; Maike Schmidt; Suk-Won Jin; Alane M Gray; Dimitris Beis; Thinh Pham; Gretchen D Frantz; Susan Palmieri; Kenneth J Hillan; Didier Y R Stainier; Frederic J de Sauvage; Weilan Ye
The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation.
Nature 2004;428(6984):754-8.
2004: Nico Ghilardi; Noelyn M Kljavin; Qi Chen; Sophie Lucas; Austin Gurney; Frederic J de Sauvage
Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):2827-33.
2004: Sarah E Craven; Kim-Chew Lim; Weilan Ye; James Douglas Engel; Frederic J de Sauvage; Arnon Rosenthal
Gata2 specifies serotonergic neurons downstream of sonic hedgehog.
Development (Cambridge, England) 2004;131(5):1165-73.
2004: Scott T Avecilla; Koichi Hattori; Beate Heissig; Rafael Tejada; Fang Liao; Koji Shido; David K Jin; Sergio Dias; Fan Zhang; Travis E Hartman; Neil R Hackett; Helen-Ann Brown Epstein; Larry Witte; Daniel J Hicklin; Peter Bohlen; Dan Eaton; David Lyden; Frederic J de Sauvage; Shahin Rafii
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis.
Nature medicine 2004;10(1):64-71.
2003: Sophie Lucas; Nico Ghilardi; Ji Li; Frederic J de Sauvage
IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15047-52.
2003: Vladimir Grachtchouk; Marina Grachtchouk; Lori Lowe; Tim Johnson; Lebing Wei; Aiqin Wang; Frederic J de Sauvage; Andrzej Dlugosz
The magnitude of hedgehog signaling activity defines skin tumor phenotype.
The EMBO journal 2003;22(11):2741-51.
2003: Bu-Er Wang; Jianyong Shou; Sarajane Ross; Hartmut Koeppen; Frederic J de Sauvage; Wei-Qiang Gao
Inhibition of epithelial ductal branching in the prostate by sonic hedgehog is indirectly mediated by stromal cells.
The Journal of biological chemistry 2003;278(20):18506-13.
2003: Sudeepta Aggarwal; Nico Ghilardi; Ming-Hong Xie; Frederic J de Sauvage; Austin Gurney
Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17.
The Journal of biological chemistry 2003;278(3):1910-4.
2002: Hong Sheng; Sara Goich; Aiqin Wang; Marina Grachtchouk; Lori Lowe; Rong Mo; Kui Lin; Frederic J de Sauvage; Hiroshi Sasaki; Chi-Chung Hui; Andrzej Dlugosz
Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype.
Cancer research 2002;62(18):5308-16.
2002: Nico Ghilardi; Ji Li; Jo-Anne Hongo; Sothy Yi; Austin Gurney; Frederic J de Sauvage
A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5.
The Journal of biological chemistry 2002;277(19):16831-6.
2002: Nicholas J Skelton; Stephen Russell; Frederic J de Sauvage; Andrea G Cochran
Amino acid determinants of beta-hairpin conformation in erythropoeitin receptor agonist peptides derived from a phage display library.
Journal of molecular biology 2002;316(5):1111-25.
2002: Marie-Dominique Filippi; Françoise Porteu; Françoise Le Pesteur; Valérie Schiavon; Gaël A Millot; William Vainchenker; Frederic J de Sauvage; Anne Dubart Kupperschmitt; Françoise Sainteny
Requirement for mitogen-activated protein kinase activation in the response of embryonic stem cell-derived hematopoietic cells to thrombopoietin in vitro.
Blood 2002;99(4):1174-82.
2001: Jianyong Shou; Sarajane Ross; Hartmut Koeppen; Frederic J de Sauvage; Wei-Qiang Gao
Dynamics of notch expression during murine prostate development and tumorigenesis.
Cancer research 2001;61(19):7291-7.
2001: Jeannette Bonifas; S Pennypacker; Pao-Tien Chuang; Andrew P McMahon; M Williams; Arnon Rosenthal; Frederic J de Sauvage; Ervin H Epstein
Activation of expression of hedgehog target genes in basal cell carcinomas.
The Journal of investigative dermatology 2001;116(5):739-42.
2001: J Zhang; A Rosenthal; Frederic J de Sauvage; Ramesh A Shivdasani
Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus.
Developmental biology 2001;229(1):188-202.
2000: Marie-Dominique Filippi; Françoise Porteu; Françoise Le Pesteur; Philippe Rameau; Maria Nogueira; Najet Debili; William Vainchenker; Frederic J de Sauvage; A D Kupperschmitt; Françoise Sainteny
Embryonic stem cell differentiation to hematopoietic cells: A model to study the function of various regions of the intracytoplasmic domain of cytokine receptors in vitro.
Experimental hematology 2000;28(12):1363-72.
2000: Q Chen; Nico Ghilardi; H Wang; T Baker; Ming-Hong Xie; Austin Gurney; Iqbal Grewal; Frederic J de Sauvage
Development of Th1-type immune responses requires the type I cytokine receptor TCCR.
Nature 2000;407(6806):916-20.
2000: Jo-Anne Hongo; Siao Ping Tsai; Barbara Moffat; K A Schroeder; C Jung; Anan Chuntharapai; PA Lampe; Eugene M Johnson; Frederic J de Sauvage; Mark P Armanini; H Phillips; Brigitte Devaux
Characterization of novel neutralizing monoclonal antibodies specific to human neurturin.
Hybridoma 2000;19(4):303-15.
2000: M Murone; Shiuh-Ming Luoh; D Stone; W Li; Austin Gurney; Mark P Armanini; C Grey; Arnon Rosenthal; Frederic J de Sauvage
Gli regulation by the opposing activities of fused and suppressor of fused.
Nature cell biology 2000;2(5):310-2.
2000: Shiuh-Ming Luoh; Eric Stefanich; Gregg P Solar; H Steinmetz; T Lipari; Tamara I Pestina; Carl W Jackson; Frederic J de Sauvage
Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo.
Molecular and cellular biology 2000;20(2):507-15.
1999: DM Stone; M Murone; Shiuh-Ming Luoh; W Ye; Mark P Armanini; Austin Gurney; H Phillips; J Brush; A Goddard; Frederic J de Sauvage; Arnon Rosenthal
Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli.
Journal of cell science 1999;112 ( Pt 23)():4437-48.
1999: M Murone; Arnon Rosenthal; Frederic J de Sauvage
Hedgehog signal transduction: from flies to vertebrates.
Experimental cell research 1999;253(1):25-33.
1999: M Murone; Arnon Rosenthal; Frederic J de Sauvage
Sonic hedgehog signaling by the patched-smoothened receptor complex.
Current biology : CB 1999;9(2):76-84.
1999: R Stoffel; S Ziegler; Nico Ghilardi; B Ledermann; Frederic J de Sauvage; Radek C Skoda
Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):698-702.
1998: D Carpenter; DM Stone; J Brush; A Ryan; Mark P Armanini; Gretchen D Frantz; Arnon Rosenthal; Frederic J de Sauvage
Characterization of two patched receptors for the vertebrate hedgehog protein family.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13630-4.
1998: AK Lewis; Gretchen D Frantz; D A Carpenter; Frederic J de Sauvage; Wei-Qiang Gao
Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.
Mechanisms of development 1998;78(1-2):159-63.
1998: Y Enokido; Frederic J de Sauvage; J A Hongo; Natalia Ninkina; A Rosenthal; Vladimir L Buchman; Alun M Davies
GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin.
Current biology : CB 1998;8(18):1019-22.
1998: Gregg P Solar; W G Kerr; F C Zeigler; D Hess; C Donahue; Frederic J de Sauvage; DL Eaton
Role of c-mpl in early hematopoiesis.
Blood 1998;92(1):4-10.
1998: Frederic J de Sauvage; Jean-Luc Villeval; Ramesh A Shivdasani
Regulation of megakaryocytopoiesis and platelet production: lessons from animal models.
The Journal of laboratory and clinical medicine 1998;131(6):496-501.
1998: Jeffrey Milbrandt; Frederic J de Sauvage; Timothy J Fahrner; Robert H Baloh; Melanie L Leitner; Malú G Tansey; PA Lampe; Robert O. Heuckeroth; PT Kotzbauer; KS Simburger; Judith P Golden; Jamie Andrew Davies; R Vejsada; Ann C Kato; Mary Hynes; D Sherman; Merry Nishimura; LC Wang; Richard Vandlen; Barbara Moffat; RD Klein; Kris T Poulsen; C Gray; A Garces; Eugene M Johnson
Persephin, a novel neurotrophic factor related to GDNF and neurturin.
Neuron 1998;20(2):245-53.
1998: Q Chen; Gregg P Solar; DL Eaton; Frederic J de Sauvage
IL-3 does not contribute to platelet production in c-Mpl-deficient mice.
Stem cells (Dayton, Ohio) 1998;16 Suppl 2():31-6.
1998: M Murone; D A Carpenter; Frederic J de Sauvage
Hematopoietic deficiencies in c-mpl and TPO knockout mice.
Stem cells (Dayton, Ohio) 1998;16(1):1-6.
1998: J Xie; M Murone; Shiuh-Ming Luoh; A Ryan; Q Gu; C Zhang; Jeannette Bonifas; C W Lam; Mary Hynes; A Goddard; Arnon Rosenthal; Ervin H Epstein; Frederic J de Sauvage
Activating Smoothened mutations in sporadic basal-cell carcinoma.
Nature 1998;391(6662):90-2.
1997: Stuart Bunting; R Widmer; T Lipari; Linda Rangell; Hope Steinmetz; K Carver-Moore; M W Moore; Gilbert A Keller; Frederic J de Sauvage
Normal platelets and megakaryocytes are produced in vivo in the absence of thrombopoietin.
Blood 1997;90(9):3423-9.
1997: Ramesh A Shivdasani; Paul J Fielder; Gilbert A Keller; Stuart H Orkin; Frederic J de Sauvage
Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice.
Blood 1997;90(5):1821-7.
1997: Paul J Fielder; Philip E Hass; Mark Nagel; Eric Stefanich; R Widmer; G L Bennett; Gilbert A Keller; Frederic J de Sauvage; D Eaton
Human platelets as a model for the binding and degradation of thrombopoietin.
Blood 1997;89(8):2782-8.
1997: Shiuh-Ming Luoh; F Di Marco; N Levin; Mark P Armanini; Ming-Hong Xie; C Nelson; GL Bennett; M Williams; S A Spencer; Austin Gurney; Frederic J de Sauvage
Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin.
Journal of molecular endocrinology 1997;18(1):77-85.
1997: DL Eaton; Frederic J de Sauvage
Thrombopoietin: the primary regulator of megakaryocytopoiesis and thrombopoiesis.
Experimental hematology 1997;25(1):1-7.
1996: D M Stone; Mary Hynes; Mark P Armanini; T A Swanson; Q Gu; R L Johnson; M P Scott; D Pennica; A Goddard; H Phillips; Markus Noll; Joan E Hooper; Frederic J de Sauvage; Arnon Rosenthal
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog.
Nature 1996;384(6605):129-34.
1996: K Carver-Moore; Hal E Broxmeyer; Shiuh-Ming Luoh; Scott Cooper; J Peng; S A Burstein; M W Moore; Frederic J de Sauvage
Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice.
Blood 1996;88(3):803-8.
1996: J J Treanor; L Goodman; Frederic J de Sauvage; D M Stone; Kris T Poulsen; C D Beck; C Gray; Mark P Armanini; R A Pollock; F Hefti; Heidi S Phillips; A Goddard; M W Moore; A Buj-Bello; A M Davies; Naoya Asai; M Takahashi; Richard Vandlen; Christopher E Henderson; Arnon Rosenthal
Characterization of a multicomponent receptor for GDNF.
Nature 1996;382(6586):80-3.
1996: Paul J Fielder; Austin Gurney; Eric Stefanich; M Marian; M W Moore; K Carver-Moore; Frederic J de Sauvage
Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets.
Blood 1996;87(6):2154-61.
1996: N Levin; C Nelson; A Gurney; Richard Vandlen; Frederic J de Sauvage
Decreased food intake does not completely account for adiposity reduction after ob protein infusion.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1726-30.
1996: Frederic J de Sauvage; K Carver-Moore; Shiuh-Ming Luoh; A Ryan; M Dowd; D L Eaton; M W Moore
Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin.
The Journal of experimental medicine 1996;183(2):651-6.
1996: Austin Gurney; Frederic J de Sauvage
Dissection of c-Mpl and thrombopoietin function: studies of knockout mice and receptor signal transduction.
Stem cells (Dayton, Ohio) 1996;14 Suppl 1():116-23.
1995: Austin Gurney; S C Wong; william james Henzel; Frederic J de Sauvage
Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5292-6.
1995: Austin Gurney; W J Kuang; Ming-Hong Xie; B E Malloy; D L Eaton; Frederic J de Sauvage
Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin.
Blood 1995;85(4):981-8.
1994: F C Zeigler; Frederic J de Sauvage; H R Widmer; Gilbert A Keller; C Donahue; R D Schreiber; B Malloy; Philip E Hass; D Eaton; W Matthews
In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells.
Blood 1994;84(12):4045-52.
1994: S L Erickson; Frederic J de Sauvage; K Kikly; K Carver-Moore; S Pitts-Meek; N Gillett; Kathleen C F Sheehan; Robert D Schreiber; D V Goeddel; M W Moore
Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice.
Nature 1994;372(6506):560-3.
1994: Austin Gurney; K Carver-Moore; Frederic J de Sauvage; M W Moore
Thrombocytopenia in c-mpl-deficient mice.
Science (New York, N.Y.) 1994;265(5177):1445-7.
1994: Frederic J de Sauvage; Philip E Hass; S D Spencer; B E Malloy; Austin Gurney; S A Spencer; W C Darbonne; william james Henzel; S C Wong; W J Kuang
Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.
Nature 1994;369(6481):533-8.
1993: K C Garcia; Frederic J de Sauvage; M Struble; william james Henzel; D Reilly; D V Goeddel
Processing and characterization of human proguanylin expressed in Escherichia coli.
The Journal of biological chemistry 1993;268(30):22397-401.
1992: Frederic J de Sauvage; Satish Keshav; W J Kuang; N Gillett; william james Henzel; D V Goeddel
Precursor structure, expression, and tissue distribution of human guanylin.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9089-93.
1992: A W Shyjan; Frederic J de Sauvage; N A Gillett; D V Goeddel; DG Lowe
Molecular cloning of a retina-specific membrane guanylyl cyclase.
Neuron 1992;9(4):727-37.
1992: K J Koller; Frederic J de Sauvage; DG Lowe; D V Goeddel
Conservation of the kinaselike regulatory domain is essential for activation of the natriuretic peptide receptor guanylyl cyclases.
Molecular and cellular biology 1992;12(6):2581-90.
1992: Frederic J de Sauvage; richard horuk; G Bennett; Clifford Quan; J P Burnier; D V Goeddel
Characterization of the recombinant human receptor for Escherichia coli heat-stable enterotoxin.
The Journal of biological chemistry 1992;267(10):6479-82.
1991: Frederic J de Sauvage; T R Camerato; D V Goeddel
Primary structure and functional expression of the human receptor for Escherichia coli heat-stable enterotoxin.
The Journal of biological chemistry 1991;266(27):17912-8.