Humbert De Smedt

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D'hondt Catheleyne; Ponsaerts Raf; De Smedt Humbert; Bultynck Geert; Himpens Bernard
Pannexins, distant relatives of the connexin family with specific cellular functions?
Rong Yi-Ping; Bultynck Geert; Aromolaran Ademuyiwa S; Zhong Fei; Parys Jan B; De Smedt Humbert; Mignery Gregory A; Roderick H Llewelyn; Bootman Martin D; Distelhorst Clark W
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor.
de Mattia Fabrizio; Gubser Caroline; van Dommelen Michiel M T; Visch Henk-Jan; Distelmaier Felix; Postigo Antonio; Luyten Tomas; Parys Jan B; de Smedt Humbert; Smith Geoffey L; Willems Peter H G M; van Kuppeveld Frank J M
Human golgi antiapoptotic protein modulates intracellular calcium fluxes.

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All Publications

2009: D'hondt Catheleyne; Ponsaerts Raf; De Smedt Humbert; Bultynck Geert; Himpens Bernard
Pannexins, distant relatives of the connexin family with specific cellular functions?
BioEssays : news and reviews in molecular, cellular and developmental biology 2009;31(9):953-74.
2009: Rong Yi-Ping; Bultynck Geert; Aromolaran Ademuyiwa S; Zhong Fei; Parys Jan B; De Smedt Humbert; Mignery Gregory A; Roderick H Llewelyn; Bootman Martin D; Distelhorst Clark W
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14397-402.
2009: de Mattia Fabrizio; Gubser Caroline; van Dommelen Michiel M T; Visch Henk-Jan; Distelmaier Felix; Postigo Antonio; Luyten Tomas; Parys Jan B; de Smedt Humbert; Smith Geoffey L; Willems Peter H G M; van Kuppeveld Frank J M
Human golgi antiapoptotic protein modulates intracellular calcium fluxes.
Molecular biology of the cell 2009;20(16):3638-45.
2009: Vanderheyden Veerle; Wakai Takuya; Bultynck Geert; De Smedt Humbert; Parys Jan B; Fissore Rafael A
Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation.
Cell calcium 2009;46(1):56-64.
2009: Vanderheyden Veerle; Devogelaere Benoit; Missiaen Ludwig; De Smedt Humbert; Bultynck Geert; Parys Jan B
Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation.
Biochimica et biophysica acta 2009;1793(6):959-70.
2009: Van den Bergh Karolien; Hooijkaas Herbert; Blockmans Daniel; Westhovens René; Op De Beéck Katrijn; Verschueren Patrick; Dufour Diana; van de Merwe Joop P; Fijak Monika; Klug Jörg; Michiels Georges; Devogelaere Benoit; De Smedt Humbert; Derua Rita; Waelkens Etienne; Blanckaert Norbert; Bossuyt Xavier
Heterogeneous nuclear ribonucleoprotein h1, a novel nuclear autoantigen.
Clinical chemistry 2009;55(5):946-54.
2008: Ito Junya; Yoon Sook-Young; Lee Bora; Vanderheyden Veerle; Vermassen Elke; Wojcikiewicz Richard; Alfandari Dominique; De Smedt Humbert; Parys Jan B; Fissore Rafael A
Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs.
Developmental biology 2008;320(2):402-13.
2008: Rong Yi-Ping; Aromolaran Ademuyiwa S; Bultynck Geert; Zhong Fei; Li Xiang; McColl Karen; Matsuyama Shigemi; Herlitze Stephan; Roderick H Llewelyn; Bootman Martin D; Mignery Gregory A; Parys Jan B; De Smedt Humbert; Distelhorst Clark W
Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals.
Molecular cell 2008;31(2):255-65.
2008: Devogelaere Benoit; Sammels Eva; De Smedt Humbert
The IRBIT domain adds new functions to the AHCY family.
BioEssays : news and reviews in molecular, cellular and developmental biology 2008;30(7):642-52.
2008: Szado Tania; Vanderheyden Veerle; Parys Jan B; De Smedt Humbert; Rietdorf Katja; Kotelevets Larissa; Chastre Eric; Khan Farid; Landegren Ulf; Söderberg Ola; Bootman Martin D; Roderick H Llewelyn
Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2427-32.
2008: Verbert Leen; Lee Bora; Kocks Sarah L; Assefa Zerihun; Parys Jan B; Missiaen Ludwig; Callewaert Geert; Fissore Rafael A; De Smedt Humbert; Bultynck Geert
Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling.
Biology of the cell / under the auspices of the European Cell Biology Organization 2008;100(1):39-49.
2008: Devogelaere Benoit; Verbert Leen; Parys Jan B; Missiaen Ludwig; De Smedt Humbert
The complex regulatory function of the ligand-binding domain of the inositol 1,4,5-trisphosphate receptor.
Cell calcium 2008;43(1):17-27.
2007: Devogelaere Benoit; Beullens Monique; Sammels Eva; Derua Rita; Waelkens Etienne; van Lint Johan; Parys Jan B; Missiaen Ludwig; Bollen Mathieu; De Smedt Humbert
Protein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor.
The Biochemical journal 2007;407(2):303-11.
2007: Ashworth Rachel; Devogelaere Benoit; Fabes Jez; Tunwell Richard E; Koh Kevin R; De Smedt Humbert; Patel Sandip
Molecular and functional characterization of inositol trisphosphate receptors during early zebrafish development.
The Journal of biological chemistry 2007;282(19):13984-93.
2007: Vandeput Fabrice; Combettes Laurent; Mills Stephen J; Backers Katrien; Wohlkönig Alexandre; Parys Jan B; De Smedt Humbert; Missiaen Ludwig; Dupont Geneviève; Potter Barry V L; Erneux Christophe
Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(7):1481-91.
2007: Mahieu Frank; Owsianik Grzegorz; Verbert Leen; Janssens Annelies; De Smedt Humbert; Nilius Bernd; Voets Thomas
TRPM8-independent menthol-induced Ca2+ release from endoplasmic reticulum and Golgi.
The Journal of biological chemistry 2007;282(5):3325-36.
2006: Lee Bora; Vermassen Elke; Yoon Sook-Young; Vanderheyden Veerle; Ito Junya; Alfandari Dominique; De Smedt Humbert; Parys Jan B; Fissore Rafael A
Phosphorylation of IP3R1 and the regulation of [Ca2+]i responses at fertilization: a role for the MAP kinase pathway.
Development (Cambridge, England) 2006;133(21):4355-65.
2006: Kasri Nael Nadif; Kocks Sarah L; Verbert Leen; Hébert Sébastien S; Callewaert Geert; Parys Jan B; Missiaen Ludwig; De Smedt Humbert
Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells.
Cell calcium 2006;40(1):41-51.
2006: Devogelaere Benoit; Nadif Kasri Nael; Derua Rita; Waelkens Etienne; Callewaert Geert; Missiaen Ludwig; Parys Jan B; De Smedt Humbert
Binding of IRBIT to the IP3 receptor: determinants and functional effects.
Biochemical and biophysical research communications 2006;343(1):49-56.
2006: Szlufcik Karolina; Bultynck Geert; Callewaert Geert; Missiaen Ludwig; Parys Jan B; De Smedt Humbert
The suppressor domain of inositol 1,4,5-trisphosphate receptor plays an essential role in the protection against apoptosis.
Cell calcium 2006;39(4):325-36.
2006: Kasri Nael Nadif; Török Katalin; Galione Antony; Garnham Clive; Callewaert Geert; Missiaen Ludwig; Parys Jan B; De Smedt Humbert
Endogenously bound calmodulin is essential for the function of the inositol 1,4,5-trisphosphate receptor.
The Journal of biological chemistry 2006;281(13):8332-8.
2006: Szlufcik Karolina; Missiaen Ludwig; Parys Jan B; Callewaert Geert; De Smedt Humbert
Uncoupled IP3 receptor can function as a Ca2+-leak channel: cell biological and pathological consequences.
Biology of the cell / under the auspices of the European Cell Biology Organization 2006;98(1):1-14.
2005: Vanoevelen J; Raeymaekers L; Dode L; Parys J B; De Smedt H; Callewaert G; Wuytack F; Missiaen L
Cytosolic Ca2+ signals depending on the functional state of the Golgi in HeLa cells.
Cell calcium 2005;38(5):489-95.
2005: Nadif Kasri Nael; Bultynck Geert; Parys Jan B; Callewaert Geert; Missiaen Ludwig; De Smedt Humbert
Suramin and disulfonated stilbene derivatives stimulate the Ca2+-induced Ca2+ -release mechanism in A7r5 cells.
Molecular pharmacology 2005;68(1):241-50.
2005: Tu Huiping; Wang Zhengnan; Nosyreva Elena; De Smedt Humbert; Bezprozvanny Ilya
Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms.
Biophysical journal 2005;88(2):1046-55.
2004: Van Baelen Kurt; Dode Leonard; Vanoevelen Jo; Callewaert Geert; De Smedt Humbert; Missiaen Ludwig; Parys Jan B; Raeymaekers Luc; Wuytack Frank
The Ca2+/Mn2+ pumps in the Golgi apparatus.
Biochimica et biophysica acta 2004;1742(1-3):103-12.
2004: Missiaen L; Van Acker K; Van Baelen K; Raeymaekers L; Wuytack F; Parys J B; De Smedt H; Vanoevelen J; Dode L; Rizzuto R; Callewaert G
Calcium release from the Golgi apparatus and the endoplasmic reticulum in HeLa cells stably expressing targeted aequorin to these compartments.
Cell calcium 2004;36(6):479-87.
2004: Jellerette Teru; Kurokawa Manabu; Lee Bora; Malcuit Chris; Yoon Sook-Young; Smyth Jeremy; Vermassen Elke; De Smedt Humbert; Parys Jan B; Fissore Rafael A
Cell cycle-coupled [Ca(2+)](i) oscillations in mouse zygotes and function of the inositol 1,4,5-trisphosphate receptor-1.
Developmental biology 2004;274(1):94-109.
2004: Missiaen Ludwig; Raeymaekers Luc; Dode Leonard; Vanoevelen Jo; Van Baelen Kurt; Parys Jan B; Callewaert Geert; De Smedt Humbert; Segaert Siegfried; Wuytack Frank
SPCA1 pumps and Hailey-Hailey disease.
Biochemical and biophysical research communications 2004;322(4):1204-13.
2004: Assefa Zerihun; Bultynck Geert; Szlufcik Karolina; Nadif Kasri Nael; Vermassen Elke; Goris Jozef; Missiaen Ludwig; Callewaert Geert; Parys Jan B; De Smedt Humbert
Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis.
The Journal of biological chemistry 2004;279(41):43227-36.
2004: Kasri Nael Nadif; Bultynck Geert; Smyth Jeremy; Szlufcik Karolina; Parys Jan B; Callewaert Geert; Missiaen Ludwig; Fissore Rafael A; Mikoshiba Katsuhiko; de Smedt Humbert
The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1,4,5-trisphosphate receptor is responsible for calmodulin inhibition, even though this inhibition requires Ca2+.
Molecular pharmacology 2004;66(2):276-84.
2004: Chabwine Joelle N; Van Damme Philip; Eggermont Jan; De Smedt Humbert; Missiaen Ludwig; Van Den Bosch Ludo; Parys Jan B; Robberecht Wim; Callewaert Geert
Long-lasting changes in GABA responsiveness in cultured neurons.
Neuroscience letters 2004;365(1):69-72.
2004: Vermassen Elke; Fissore Rafael A; Nadif Kasri Nael; Vanderheyden Veerle; Callewaert Geert; Missiaen Ludwig; Parys Jan B; De Smedt Humbert
Regulation of the phosphorylation of the inositol 1,4,5-trisphosphate receptor by protein kinase C.
Biochemical and biophysical research communications 2004;319(3):888-93.
2004: Bultynck Geert; Szlufcik Karolina; Kasri Nael Nadif; Assefa Zerihun; Callewaert Geert; Missiaen Ludwig; Parys Jan B; De Smedt Humbert
Thimerosal stimulates Ca2+ flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca2+-dependent intramolecular interaction.
The Biochemical journal 2004;381(Pt 1):87-96.
2004: Van Acker Kristel; Bultynck Geert; Rossi Daniela; Sorrentino Vincenzo; Boens Noel; Missiaen Ludwig; De Smedt Humbert; Parys Jan B; Callewaert Geert
The 12 kDa FK506-binding protein, FKBP12, modulates the Ca(2+)-flux properties of the type-3 ryanodine receptor.
Journal of cell science 2004;117(Pt 7):1129-37.
2004: Vanoevelen J; Raeymaekers L; Parys J B; De Smedt H; Van Baelen K; Callewaert G; Wuytack F; Missiaen L
Inositol trisphosphate producing agonists do not mobilize the thapsigargin-insensitive part of the endoplasmic-reticulum and Golgi Ca2+ store.
Cell calcium 2004;35(2):115-21.
2004: Kasri Nael Nadif; Holmes Anthony M; Bultynck Geert; Parys Jan B; Bootman Martin D; Rietdorf Katja; Missiaen Ludwig; McDonald Fraser; De Smedt Humbert; Conway Stuart J; Holmes Andrew B; Berridge Michael J; Roderick H Llewelyn
Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.
The EMBO journal 2004;23(2):312-21.
2004: Kasri Nael Nadif; Parys Jan B; Callewaert Geert; Missiaen Ludwig; De Smedt Humbert
Calmodulin and calcium-release channels.
Biological research 2004;37(4):577-82.
2004: Bultynck G; Van Acker K; Missiaen L; Callewaert G; Parys J B; De Smedt H
[Intracellular calcium-releasing channels as cellular targets for immunophilins: a molecular, functional and structural analysis]
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2004;66(4):277-303.
2003: Bultynck G; Vermassen E; Szlufcik K; De Smet P; Fissore R A; Callewaert G; Missiaen L; De Smedt H; Parys J B
Calcineurin and intracellular Ca2+-release channels: regulation or association?
Biochemical and biophysical research communications 2003;311(4):1181-93.
2003: Callewaert G; Parys J B; De Smedt H; Raeymaekers L; Wuytack F; Vanoevelen J; Van Baelen K; Simoni A; Rizzuto R; Missiaen L
Similar Ca(2+)-signaling properties in keratinocytes and in COS-1 cells overexpressing the secretory-pathway Ca(2+)-ATPase SPCA1.
Cell calcium 2003;34(2):157-62.
2003: Dewaste Valérie; Moreau Colette; De Smedt Florence; Bex Françoise; De Smedt Humbert; Wuytack Frank; Missiaen Ludwig; Erneux Christophe
The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.
The Biochemical journal 2003;374(Pt 1):41-9.
2003: Kasri Nael Nadif; Sienaert Ilse; Parys Jan B; Callewaert Geert; Missiaen Ludwig; Jeromin Andreas; De Smedt Humbert
A novel Ca2+-induced Ca2+ release mechanism in A7r5 cells regulated by calmodulin-like proteins.
The Journal of biological chemistry 2003;278(30):27548-55.
2003: Van Baelen Kurt; Vanoevelen Jo; Callewaert Geert; Parys Jan B; De Smedt Humbert; Raeymaekers Luc; Rizzuto Rosario; Missiaen Ludwig; Wuytack Frank
The contribution of the SPCA1 Ca2+ pump to the Ca2+ accumulation in the Golgi apparatus of HeLa cells assessed via RNA-mediated interference.
Biochemical and biophysical research communications 2003;306(2):430-6.
2003: Vermassen Elke; Van Acker Kristel; Annaert Wim G; Himpens Bernard; Callewaert Geert; Missiaen Ludwig; De Smedt Humbert; Parys Jan B
Microtubule-dependent redistribution of the type-1 inositol 1,4,5-trisphosphate receptor in A7r5 smooth muscle cells.
Journal of cell science 2003;116(Pt 7):1269-77.
2003: Bultynck G; Sienaert I; Parys J B; Callewaert G; De Smedt H; Boens N; Dehaen W; Missiaen L
Pharmacology of inositol trisphosphate receptors.
Pflügers Archiv : European journal of physiology 2003;445(6):629-42.
2003: Janssens Veerle; Jordens Jan; Stevens Ilse; Van Hoof Christine; Martens Ellen; De Smedt Humbert; Engelborghs Yves; Waelkens Etienne; Goris Jozef
Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A.
The Journal of biological chemistry 2003;278(12):10697-706.
2002: Nadif Kasri Nael; Bultynck Geert; Sienaert Ilse; Callewaert Geert; Erneux Christophe; Missiaen Ludwig; Parys Jan B; De Smedt Humbert
The role of calmodulin for inositol 1,4,5-trisphosphate receptor function.
Biochimica et biophysica acta 2002;1600(1-2):19-31.
2002: Smyth Jeremy T; Abbott Allison L; Lee Bora; Sienaert Ilse; Kasri Nael Nadif; De Smedt Humbert; Ducibella Tom; Missiaen Ludwig; Parys Jan B; Fissore Rafael A
Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism.
The Journal of biological chemistry 2002;277(38):35061-70.
2002: Van Acker K; Nadif Kasri N; De Smet P; Parys J B; De Smedt H; Missiaen L; Callewaert G
IP(3)-mediated Ca(2+) signals in human neuroblastoma SH-SY5Y cells with exogenous overexpression of type 3 IP(3) receptor.
Cell calcium 2002;32(2):71-81.
2002: Sienaert Ilse; Nadif Kasri Nael; Vanlingen Sara; Parys Jan B; Callewaert Geert; Missiaen Ludwig; de Smedt Humbert
Localization and function of a calmodulin-apocalmodulin-binding domain in the N-terminal part of the type 1 inositol 1,4,5-trisphosphate receptor.
The Biochemical journal 2002;365(Pt 1):269-77.
2002: Stout Marguerite A; Raeymaekers Luc; De Smedt Humbert; Casteels Rik
Characterization of Ca2+ release from heterogeneous Ca2+ stores in sarcoplasmic reticulum isolated from arterial and gastric smooth muscle.
Canadian journal of physiology and pharmacology 2002;80(6):588-603.
2002: Missiaen Ludwig; Vanoevelen Jo; Van Acker Kristel; Raeymaekers Luc; Parys Jan B; Callewaert Geert; Wuytack Frank; De Smedt Humbert
Ca(2+) signals in Pmr1-GFP-expressing COS-1 cells with functional endoplasmic reticulum.
Biochemical and biophysical research communications 2002;294(2):249-53.
2002: Bultynck G; De Smedt H; Parys J B; Callewaert G; Missiaen L
Washing out of lipophilic compounds induces a transient increase in the passive Ca(2+) leak in permeabilized A7r5 cells.
Cell calcium 2002;31(5):229-33.
2002: Missiaen Ludwig; Vanoevelen Jo; Parys Jan B; Raeymaekers Luc; De Smedt Humbert; Callewaert Geert; Erneux Christophe; Wuytack Frank
Ca2+ uptake and release properties of a thapsigargin-insensitive nonmitochondrial Ca2+ store in A7r5 and 16HBE14o- cells.
The Journal of biological chemistry 2002;277(9):6898-902.
2001: Bultynck G; Rossi D; Callewaert G; Missiaen L; Sorrentino V; Parys J B; De Smedt H
The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different.
The Journal of biological chemistry 2001;276(50):47715-24.
2001: Missiaen L; Van Acker K; Parys J B; De Smedt H; Van Baelen K; Weidema A F; Vanoevelen J; Raeymaekers L; Renders J; Callewaert G; Rizzuto R; Wuytack F
Baseline cytosolic Ca2+ oscillations derived from a non-endoplasmic reticulum Ca2+ store.
The Journal of biological chemistry 2001;276(42):39161-70.
2001: Malfait M; Gomez P; van Veen T A; Parys J B; De Smedt H; Vereecke J; Himpens B
Effects of hyperglycemia and protein kinase C on connexin43 expression in cultured rat retinal pigment epithelial cells.
The Journal of membrane biology 2001;181(1):31-40.
2001: Vanlingen S; Sipma H; De Smet P; Callewaert G; Missiaen L; De Smedt H; Parys J B
Modulation of inositol 1,4,5-trisphosphate binding to the various inositol 1,4,5-trisphosphate receptor isoforms by thimerosal and cyclic ADP-ribose.
Biochemical pharmacology 2001;61(7):803-9.
2001: Bultynck G; De Smet P; Rossi D; Callewaert G; Missiaen L; Sorrentino V; De Smedt H; Parys J B
Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.
The Biochemical journal 2001;354(Pt 2):413-22.
2001: Missiaen L; Callewaert G; De Smedt H; Parys J B
2-Aminoethoxydiphenyl borate affects the inositol 1,4,5-trisphosphate receptor, the intracellular Ca2+ pump and the non-specific Ca2+ leak from the non-mitochondrial Ca2+ stores in permeabilized A7r5 cells.
Cell calcium 2001;29(2):111-6.
2001: Maes K; Missiaen L; Parys J B; De Smet P; Sienaert I; Waelkens E; Callewaert G; De Smedt H
Mapping of the ATP-binding sites on inositol 1,4,5-trisphosphate receptor type 1 and type 3 homotetramers by controlled proteolysis and photoaffinity labeling.
The Journal of biological chemistry 2001;276(5):3492-7.
2000: Bultynck G; De Smet P; Weidema A F; Ver Heyen M; Maes K; Callewaert G; Missiaen L; Parys J B; De Smedt H
Effects of the immunosuppressant FK506 on intracellular Ca2+ release and Ca2+ accumulation mechanisms.
The Journal of physiology 2000;525 Pt 3():681-93.
2000: Maes K; Missiaen L; De Smet P; Vanlingen S; Callewaert G; Parys J B; De Smedt H
Differential modulation of inositol 1,4,5-trisphosphate receptor type 1 and type 3 by ATP.
Cell calcium 2000;27(5):257-67.
2000: Vanlingen S; Sipma H; De Smet P; Callewaert G; Missiaen L; De Smedt H; Parys J B
Ca2+ and calmodulin differentially modulate myo-inositol 1,4, 5-trisphosphate (IP3)-binding to the recombinant ligand-binding domains of the various IP3 receptor isoforms.
The Biochemical journal 2000;346 Pt 2():275-80.
2000: van Acker K; Bautmans B; Bultynck G; Maes K; Weidema A F; de Smet P; Parys J B; de Smedt H; Missiaen L; Callewaert G
Mapping of IP(3)-mediated Ca(2+) signals in single human neuroblastoma SH-SY5Y cells: cell volume shaping the Ca(2+) signal.
Journal of neurophysiology 2000;83(2):1052-7.
2000: Adkins C E; Morris S A; De Smedt H; Sienaert I; Török K; Taylor C W
Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors.
The Biochemical journal 2000;345 Pt 2():357-63.
2000: Missiaen L; Callewaert G; Parys J B; Wuytack F; Raeymaekers L; Droogmans G; Nilius B; Eggermont J; De Smedt H
[Intracellular calcium: physiology and physiopathology]
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2000;62(6):471-99.
1999: Missiaen L; De Smedt H; Parys J B; Van Acker K; De Smet P; Callewaert G
Cytosolic Ca(2+) controls the loading dependence of IP(3)-induced Ca(2+) release.
Biochemical and biophysical research communications 1999;264(3):967-71.
1999: De Smet P; Parys J B; Callewaert G; Weidema A F; Hill E; De Smedt H; Erneux C; Sorrentino V; Missiaen L
Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca(2+) pumps.
Cell calcium 1999;26(1-2):9-13.
1999: De Smet P; Parys J B; Vanlingen S; Bultynck G; Callewaert G; Galione A; De Smedt H; Missiaen L
The relative order of IP3 sensitivity of types 1 and 3 IP3 receptors is pH dependent.
Pflügers Archiv : European journal of physiology 1999;438(2):154-8.
1999: Missiaen L; Parys J B; Weidema A F; Sipma H; Vanlingen S; De Smet P; Callewaert G; De Smedt H
The bell-shaped Ca2+ dependence of the inositol 1,4, 5-trisphosphate-induced Ca2+ release is modulated by Ca2+/calmodulin.
The Journal of biological chemistry 1999;274(20):13748-51.
1999: Sipma H; De Smet P; Sienaert I; Vanlingen S; Missiaen L; Parys J B; De Smedt H
Modulation of inositol 1,4,5-trisphosphate binding to the recombinant ligand-binding site of the type-1 inositol 1,4, 5-trisphosphate receptor by Ca2+ and calmodulin.
The Journal of biological chemistry 1999;274(17):12157-62.
1999: Missiaen L; Sipma H; Parys J B; De Smet P; Callewaert G; Hill E; McCarthy T V; De Smedt H
IP3-induced Ca2+ release in A7r5 vascular smooth-muscle cells represents a partial emptying of the stores and not an all-or-none Ca2+ release of separate quanta.
Pflügers Archiv : European journal of physiology 1999;437(5):691-4.
1999: Maes K; Missiaen L; Parys J B; Sienaert I; Bultynck G; Zizi M; De Smet P; Casteels R; De Smedt H
Adenine-nucleotide binding sites on the inositol 1,4,5-trisphosphate receptor bind caffeine, but not adenophostin A or cyclic ADP-ribose.
Cell calcium 1999;25(2):143-52.
1999: Vanlingen S; Sipma H; Missiaen L; De Smedt H; De Smet P; Casteels R; Parys J B
Modulation of type 1, 2 and 3 inositol 1,4,5-trisphosphate receptors by cyclic ADP-ribose and thimerosal.
Cell calcium 1999;25(2):107-14.
1999: Van Den Bosch L; Verhoeven K; De Smedt H; Wuytack F; Missiaen L; Robberecht W
Calcium handling proteins in isolated spinal motoneurons.
Life sciences 1999;65(15):1597-606.
1998: Viana F; de Smedt H; Droogmans G; Nilius B
Calcium signalling through nucleotide receptor P2Y2 in cultured human vascular endothelium.
Cell calcium 1998;24(2):117-27.
1998: Sienaert I; Huyghe S; Parys J B; Malfait M; Kunzelmann K; De Smedt H; Verleden G M; Missiaen L
ATP-induced Ca2+ signals in bronchial epithelial cells.
Pflügers Archiv : European journal of physiology 1998;436(1):40-8.
1998: Missiaen L; Parys J B; Sienaert I; Maes K; Kunzelmann K; Takahashi M; Tanzawa K; De Smedt H
Functional properties of the type-3 InsP3 receptor in 16HBE14o- bronchial mucosal cells.
The Journal of biological chemistry 1998;273(15):8983-6.
1998: Missiaen L; Parys J B; De Smedt H; Sienaert I; Sipma H; Vanlingen S; Maes K; Kunzelmann K; Casteels R
Inhibition of inositol trisphosphate-induced calcium release by cyclic ADP-ribose in A7r5 smooth-muscle cells and in 16HBE14o- bronchial mucosal cells.
The Biochemical journal 1998;329 ( Pt 3)():489-95.
1997: Vanlingen S; Parys J B; Missiaen L; De Smedt H; Wuytack F; Casteels R
Distribution of inositol 1,4,5-trisphosphate receptor isoforms, SERCA isoforms and Ca2+ binding proteins in RBL-2H3 rat basophilic leukemia cells.
Cell calcium 1997;22(6):475-86.
1997: Sienaert I; Missiaen L; De Smedt H; Parys J B; Sipma H; Casteels R
Molecular and functional evidence for multiple Ca2+-binding domains in the type 1 inositol 1,4,5-trisphosphate receptor.
The Journal of biological chemistry 1997;272(41):25899-906.
1997: Missiaen L; De Smedt H; Parys J B; Sipma H; Maes K; Vanlingen S; Sienaert I; Van Driessche W; Casteels R
Synergism between hypotonically induced calcium release and fatty acyl-CoA esters induced calcium release from intracellular stores.
Cell calcium 1997;22(3):151-6.
1997: Missiaen L; De Smedt H; Parys J B; Casteels R
Effect of a cytosolic Ca2+ concentration ramp on InsP3-induced Ca2+ release in A7r5 smooth-muscle cells and in EBTr cells from tracheal mucosa.
Biochemical and biophysical research communications 1997;237(2):354-8.
1997: Eggermont J; Buyse G; Voets T; Tytgat J; De Smedt H; Droogmans G; Nilius B
Alternative splicing of ClC-6 (a member of the CIC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific.
The Biochemical journal 1997;325 ( Pt 1)():269-76.
1997: De Smedt F; Missiaen L; Parys J B; Vanweyenberg V; De Smedt H; Erneux C
Isoprenylated human brain type I inositol 1,4,5-trisphosphate 5-phosphatase controls Ca2+ oscillations induced by ATP in Chinese hamster ovary cells.
The Journal of biological chemistry 1997;272(28):17367-75.
1997: Missiaen L; De Smedt H; Parys J B; Sienaert I; Sipma H; Vanlingen S; Casteels R
Slow kinetics of inositol 1,4,5-trisphosphate-induced Ca2+ release: is the release 'quantal' or 'non-quantal'?
The Biochemical journal 1997;323 ( Pt 1)():123-30.
1997: De Smedt H; Missiaen L; Parys J B; Henning R H; Sienaert I; Vanlingen S; Gijsens A; Himpens B; Casteels R
Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.
The Biochemical journal 1997;322 ( Pt 2)():575-83.
1996: Sienaert I; De Smedt H; Parys J B; Missiaen L; Vanlingen S; Sipma H; Casteels R
Characterization of a cytosolic and a luminal Ca2+ binding site in the type I inositol 1,4,5-trisphosphate receptor.
The Journal of biological chemistry 1996;271(43):27005-12.
1996: Missiaen L; De Smedt H; Parys J B; Raeymaekers L; Droogmans G; Van Den Bosch L; Casteels R
Kinetics of the non-specific calcium leak from non-mitochondrial calcium stores in permeabilized A7r5 cells.
The Biochemical journal 1996;317 ( Pt 3)():849-53.
1996: Missiaen L; De Smedt H; Parys J B; Sienaert I; Valingen S; Casteels R
Threshold for inositol 1,4,5-trisphosphate action.
The Journal of biological chemistry 1996;271(21):12287-93.
1996: Missiaen L; De Smedt H; Parys J B; Sienaert I; Vanlingen S; Droogmans G; Nilius B; Casteels R
Hypotonically induced calcium release from intracellular calcium stores.
The Journal of biological chemistry 1996;271(9):4601-4.
1996: Missiaen L; De Smedt H; Parys J B; Sienaert I; Vanlingen S; Casteels R
Effects of luminal Ca2+ on inositol trisphosphate-induced Ca2+ release: facts or artifacts?
Cell calcium 1996;19(1):91-3.
1996: Missiaen L; Lemaire F X; Parys J B; De Smedt H; Sienaert I; Casteels R
Initiation sites for Ca2+ signals in endothelial cells.
Pflügers Archiv : European journal of physiology 1996;431(3):318-24.
1996: Missiaen L; Parys J B; De Smedt H; Sienaert I; Bootman M D; Casteels R
Control of the Ca2+ release induced by myo-inositol trisphosphate and the implication in signal transduction.
Sub-cellular biochemistry 1996;26():59-95.
1995: Himpens B; Proot P; Neyts J; De Smedt H; De Clercq E; Casteels R
Human cytomegalovirus modulates the Ca2+ response to vasopressin and ATP in fibroblast cultures.
Cell calcium 1995;18(2):111-9.
1995: Missiaen L; Parys J B; De Smedt H; Lemaire F X; Sienaert I; Bootman M D; Casteels R
Slow kinetics of InsP3-induced Ca2+ release: differences between uni- and bi-directional 45Ca2+ fluxes.
Cell calcium 1995;18(2):100-10.
1995: Missiaen L; Parys J B; De Smedt H; Sienaert I; Henning R H; Casteels R
Opening up Ca2+ stores with InsP3.
Nature 1995;376(6538):299-300; author reply 301.
1995: Mertens L; Van den Bosch L; Verboomen H; Wuytack F; De Smedt H; Eggermont J
Sequence and spatial requirements for regulated muscle-specific processing of the sarco/endoplasmic reticulum Ca(2+)-ATPase 2 gene transcript.
The Journal of biological chemistry 1995;270(18):11004-11.
1995: Parys J B; Missiaen L; De Smedt H; Sienaert I; Henning R H; Casteels R
Quantal release of calcium in permeabilized A7r5 cells is not caused by intrinsic inactivation of the inositol trisphosphate receptor.
Biochemical and biophysical research communications 1995;209(2):451-6.
1995: Parys J B; de Smedt H; Missiaen L; Bootman M D; Sienaert I; Casteels R
Rat basophilic leukemia cells as model system for inositol 1,4,5-trisphosphate receptor IV, a receptor of the type II family: functional comparison and immunological detection.
Cell calcium 1995;17(4):239-49.
1995: De Smedt H; Parys J B
[Molecular and functional diversity of inositol triphosphate-induced Ca(2+) release]
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1995;57(5):423-58.
1994: Missiaen L; Oike M; Bootman M D; De Smedt H; Parys J B; Casteels R
Vasopressin responses in electrically coupled A7r5 cells.
Pflügers Archiv : European journal of physiology 1994;428(3-4):283-7.
1994: Van den Bosch L; Eggermont J; De Smedt H; Mertens L; Wuytack F; Casteels R
Regulation of splicing is responsible for the expression of the muscle-specific 2a isoform of the sarco/endoplasmic-reticulum Ca(2+)-ATPase.
The Biochemical journal 1994;302 ( Pt 2)():559-66.
1994: Himpens B; De Smedt H; Bollen M
Modulation of nucleocytosolic [Ca2+] gradient in smooth muscle by protein phosphorylation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(11):879-83.
1994: De Smedt H; Missiaen L; Parys J B; Bootman M D; Mertens L; Van Den Bosch L; Casteels R
Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.
The Journal of biological chemistry 1994;269(34):21691-8.
1994: Missiaen L; Parys J B; De Smedt H; Himpens B; Casteels R
Inhibition of inositol trisphosphate-induced calcium release by caffeine is prevented by ATP.
The Biochemical journal 1994;300 ( Pt 1)():81-4.
1994: Missiaen L; De Smedt H; Parys J B; Casteels R
Co-activation of inositol trisphosphate-induced Ca2+ release by cytosolic Ca2+ is loading-dependent.
The Journal of biological chemistry 1994;269(10):7238-42.
1994: Van Driessche W; De Smet P; de Smedt H
Poorly selective cation channels in the apical membrane of A6 cells.
Pflügers Archiv : European journal of physiology 1994;426(5):387-95.
1994: Missiaen L; De Smedt H; Pary J B; Oike M; Casteels R
Kinetics of empty store-activated Ca2+ influx in HeLa cells.
The Journal of biological chemistry 1994;269(8):5817-23.
1994: Himpens B; De Smedt H; Casteels R
Subcellular Ca(2+)-gradients in A7r5 vascular smooth muscle.
Cell calcium 1994;15(1):55-65.
1994: Missiaen L; Parys J B; De Smedt H; Oike M; Casteels R
Partial calcium release in response to submaximal inositol 1,4,5-trisphosphate receptor activation.
Molecular and cellular endocrinology 1994;98(2):147-56.
1993: Parys J B; Missiaen L; De Smedt H; Casteels R
Loading dependence of inositol 1,4,5-trisphosphate-induced Ca2+ release in the clonal cell line A7r5. Implications for the mechanism of quantal Ca2+ release.
The Journal of biological chemistry 1993;268(33):25206-12.
1993: Missiaen L; Parys J B; Bootman M D; De Smedt H; Droogmans G; Casteels R
Normal Ca2+ signalling in glutathione-depleted and dithiothreitol-treated HeLa cells.
Pflügers Archiv : European journal of physiology 1993;423(5-6):480-4.
1993: De Jaegere S; Wuytack F; De Smedt H; Van den Bosch L; Casteels R
Alternative processing of the gene transcripts encoding a plasma-membrane and a sarco/endoplasmic reticulum Ca2+ pump during differentiation of BC3H1 muscle cells.
Biochimica et biophysica acta 1993;1173(2):188-94.
1993: Tshipamba M; De Smedt H; Missiaen L; Himpens B; Van Den Bosch L; Borghgraef R
Ca2+ dependence of inositol 1,4,5-trisphosphate-induced Ca2+ release in renal epithelial LLC-PK1 cells.
Journal of cellular physiology 1993;155(1):96-103.
1992: Missiaen L; De Smedt H; Droogmans G; Casteels R
2,5-Di-(tert-butyl)-1,4-benzohydroquinone and cyclopiazonic acid decrease the Ca2+ permeability of endoplasmic reticulum.
European journal of pharmacology 1992;227(4):391-4.
1992: Wuytack F; Raeymaekers L; De Smedt H; Eggermont J A; Missiaen L; Van Den Bosch L; De Jaegere S; Verboomen H; Plessers L; Casteels R
Ca(2+)-transport ATPases and their regulation in muscle and brain.
Annals of the New York Academy of Sciences 1992;671():82-91.
1992: Verboomen H; Wuytack F; De Smedt H; Himpens B; Casteels R
Functional difference between SERCA2a and SERCA2b Ca2+ pumps and their modulation by phospholamban.
The Biochemical journal 1992;286 ( Pt 2)():591-5.
1992: Lehotsky J; Raeymaekers L; Missiaen L; Wuytack F; De Smedt H; Casteels R
Stimulation of the catalytic cycle of the Ca2+ pump of porcine plasma-membranes by negatively charged phospholipids.
Biochimica et biophysica acta 1992;1105(1):118-24.
1992: Heirwegh K P; De Smedt H; Vermeir M
Analysis of membrane-bound acceptors. A correction function for non-specific accumulation of poorly water-soluble hydrophobic or amphipathic ligands based on the ligand partition concept.
Biochemical pharmacology 1992;43(4):701-4.
1991: de Smedt H; Eggermont J A; Wuytack F; Parys J B; Van den Bosch L; Missiaen L; Verbis J; Casteels R
Isoform switching of the sarco(endo)plasmic reticulum Ca2+ pump during differentiation of BC3H1 myoblasts.
The Journal of biological chemistry 1991;266(11):7092-5.
1991: Van den Bosch L; De Smedt H; Borghgraef R
Influence of PMA and a low extracellular Ca2+ concentration on the development of the Na(+)-dependent hexose carrier in LLC-PK1 cells.
Biochimica et biophysica acta 1991;1092(2):244-50.
1991: Missiaen L; De Smedt H; Droogmans G; Declerck I; Plessers L; Casteels R
Uptake characteristics of the InsP3-sensitive and -insensitive Ca2+ pools in porcine aortic smooth-muscle cells: different Ca2+ sensitivity of the Ca2(+)-uptake mechanism.
Biochemical and biophysical research communications 1991;174(3):1183-8.
1991: De Smedt H; Parys J B; Himpens B; Missiaen L; Borghgraef R
Changes in the mechanism of Ca2(+) mobilization during the differentiation of BC3H1 muscle cells.
The Biochemical journal 1991;273(Pt 1)():219-23.
1990: Van Den Bosch L; De Smedt H; Borghgraef R
Development of the Na(+)-dependent hexose carrier in LLC-PK1 cells is dependent on microtubules.
Biochimica et biophysica acta 1990;1030(2):223-30.
1990: Parys J B; De Smedt H; Van Den Bosch L; Geuns J; Borghgraef R
Regulation of the Na(+)-dependent and the Na(+)-independent polyamine transporters in renal epithelial cells (LLC-PK1).
Journal of cellular physiology 1990;144(3):365-75.
1990: Missiaen L; Declerck I; Droogmans G; Plessers L; De Smedt H; Raeymaekers L; Casteels R
Agonist-dependent Ca2+ and Mn2+ entry dependent on state of filling of Ca2+ stores in aortic smooth muscle cells of the rat.
The Journal of physiology 1990;427():171-86.
1990: Missiaen L; De Smedt H; Droogmans G; Wuytack F; Raeymaekers L; Casteels R
Ruthenium red and compound 48/80 inhibit the smooth-muscle plasma-membrane Ca2+ pump via interaction with associated polyphosphoinositides.
Biochimica et biophysica acta 1990;1023(3):449-54.
1990: Van Den Bosch L; De Smedt H; Missiaen L; Parys J B; Borghgraef R
Transport systems for polyamines in the established renal cell line LLC-PK. Polarized expression of an Na(+)-dependent transporter.
The Biochemical journal 1990;265(2):609-12.
1989: Van den Bosch L; De Smedt H; Borghgraef R
Different pattern of differentiation in two LLC-PK1 clones.
Journal of cellular physiology 1989;141(3):483-9.
1989: Missiaen L; Raeymaekers L; Wuytack F; Vrolix M; de Smedt H; Casteels R
Phospholipid-protein interactions of the plasma-membrane Ca2+-transporting ATPase. Evidence for a tissue-dependent functional difference.
The Biochemical journal 1989;263(3):687-94.
1989: Missiaen L; Wuytack F; De Smedt H; Amant F; Casteels R
AIF4-induced inhibition of the ATPase activity, the Ca2+-transport activity and the phosphoprotein-intermediate formation of plasma-membrane and endo(sarco)plasmic-reticulum Ca2+-transport ATPases in different tissues. Evidence for a tissue-dependent functional difference.
The Biochemical journal 1989;261(2):655-60.
1989: De Smedt H; Van den Bosch L; Geuns J; Borghgraef R
Polyamine transport systems in the LLC-PK1 renal epithelial established cell line.
Biochimica et biophysica acta 1989;1012(2):171-7.
1989: Heirwegh K P; Meuwissen J A; Van den Steen P; De Smedt H
Modelling of chemical reactions catalysed by membrane-bound enzymes. Determination and significance of the kinetic constants.
Biochimica et biophysica acta 1989;995(2):151-9.
1989: Van den Bosch L; De Smedt H; Borghgraef R
Characteristics of Na+-dependent hexose transport in OK, an established renal epithelial cell line.
Biochimica et biophysica acta 1989;979(1):91-8.
1988: Heirwegh K P; Meuwissen J A; Vermeir M; De Smedt H
Liposomes as carriers of poorly water-soluble substrates: linear modelling of membrane systems with catalytic or binding sites of different facedness. Significance of experimental membrane partition coefficients and of kinetic and equilibrium parameters.
The Biochemical journal 1988;254(1):101-8.
1988: Missiaen L; Wuytack F; De Smedt H; Vrolix M; Casteels R
AlF4- reversibly inhibits 'P'-type cation-transport ATPases, possibly by interacting with the phosphate-binding site of the ATPase.
The Biochemical journal 1988;253(3):827-33.
1988: De Smedt H; Van Den Bosch L; Parys J B; Wuytack F; Borghgraef R
Calcium transport systems in renal epithelial established cell lines.
Progress in clinical and biological research 1988;252():255-60.
1987: De Smedt H; Parys J B; Borghgraef R
Calmodulin and calmodulin-binding proteins in the renal brush border.
Biochimica et biophysica acta 1987;929(1):103-13.
1986: Parys J B; De Smedt H; Borghgraef R
Calcium transport systems in the LLC-PK1 renal epithelial established cell line.
Biochimica et biophysica acta 1986;888(1):70-81.
1985: Parys J B; De Smedt H; Vandenberghe P; Borghgraef R
Characterization of ATP-driven calcium uptake in renal basal-lateral and renal endoplasmic reticulum membrane vesicles.
Cell calcium 1985;6(5):413-29.
1984: De Smedt H; Parys J B; Wuytack F; Borghgraef R
Calcium-induced phosphorylations and [125I]calmodulin binding in renal membrane preparations.
Biochimica et biophysica acta 1984;776(1):122-32.
1983: De Smedt H; Parys J B; Borghgraef R; Wuytack F
Phosphorylated intermediates of (Ca2+ + Mg2+)-ATPase and alkaline phosphatase in renal plasma membranes.
Biochimica et biophysica acta 1983;728(3):409-18.
1981: De Smedt H; Parys J B; Borghgraef R; Wuytack F
Calmodulin stimulation of renal (Ca2+ + Mg2+)-ATPase.
FEBS letters 1981;131(1):60-2.
1981: Gögelein H; De Smedt H; Van Driessche W; Borghgraef R
The effect of lanthanum on alamethicin channels in black lipid bilayers.
Biochimica et biophysica acta 1981;640(1):185-94.
1980: Paulussen-Noterman N; De Smedt H; Borghgraef R
Temperature dependence of the interaction of lipophilic drugs with (Na+ + K+)-ATPase from pig kidney [proceedings]
Archives internationales de physiologie et de biochimie 1980;88(1):P17-P18.

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