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Humbert De Smedt

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Haidar Akl; Humbert De Smedt; Marc Hoylaerts; Alexandre Kauskot; Tomas Luyten; Giovanni Monaco; Jan B Parys; Ilse Vandecaetsbeek; Kirsten Welkenhuyzen; Geert Bultynck
HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines.
Jean-Paul Decuypere; Dimphny Kindt; Tomas Luyten; Ludwig Missiaen; Geert Bultynck; Humbert De Smedt; Kirsten Welkenhuyzen; Jan B Parys
mTOR-Controlled Autophagy Requires Intracellular Ca(2+) Signaling.
Giovanni Monaco; Jan B Parys; MC Beckers; Humbert De Smedt; Hristina Ivanova; Ludwig Missiaen; Geert Bultynck
Profiling of the Bcl-2/Bcl-X(L)-binding sites on type 1 IP(3) receptor.

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2013: Haidar Akl; Humbert De Smedt; Marc Hoylaerts; Alexandre Kauskot; Tomas Luyten; Giovanni Monaco; Jan B Parys; Ilse Vandecaetsbeek; Kirsten Welkenhuyzen; Geert Bultynck
HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines.
Haematologica 2013;98(4):e49-51.
2013: Jean-Paul Decuypere; Dimphny Kindt; Tomas Luyten; Ludwig Missiaen; Geert Bultynck; Humbert De Smedt; Kirsten Welkenhuyzen; Jan B Parys
mTOR-Controlled Autophagy Requires Intracellular Ca(2+) Signaling.
PloS one 2013;8(4):e61020.
2012: Giovanni Monaco; Jan B Parys; MC Beckers; Humbert De Smedt; Hristina Ivanova; Ludwig Missiaen; Geert Bultynck
Profiling of the Bcl-2/Bcl-X(L)-binding sites on type 1 IP(3) receptor.
Biochemical and biophysical research communications 2012;428(1):31-5.
2012: D Mekahli; Geert Bultynck; Humbert De Smedt; Rik Gijsbers; E N Levtchenko; T Luyten; Jan B Parys; E Sammels; L P van den Heuvel; K Welkenhuyzen; Ludwig Missiaen
Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release.
Cell calcium 2012;51(6):452-8.
2012: Geert Bultynck; Wim De Borggraeve; Humbert De Smedt; Nadine Henke; Hristina Ivanova; Santeri Kiviluoto; Tomas Luyten; Ludwig Missiaen; Koen Nuyts; Jan B Parys; Volodymyr Rybalchenko; Lars Schneider; Ilya Bezprozvanny; Axel Methner
The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.
The Journal of biological chemistry 2012;287(4):2544-57.
2012: Jan B Parys; Humbert De Smedt
Inositol 1,4,5-trisphosphate and its receptors.
Advances in experimental medicine and biology 2012;740():255-79.
2011: Jean-Paul Decuypere; Michael Dewaele; Tomas Luyten; Ludwig Missiaen; Jordi Molgó; Jan B Parys; Raf Ponsaerts; Kirsten Welkenhuyzen; Patrizia Agostinis; Humbert De Smedt; Geert Bultynck
Ins(1,4,5)P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated.
Autophagy 2011;7(12):1472-89.
2011: Joana Raquel Martins; Eva Sammels; Rainer Schreiber; Fadi Aldehni; Margarida D Amaral; Luka Alexander Clarke; Shehrazade Dahimène; Humbert De Smedt; Patthara Kongsuphol; Karl Kunzelmann
F508del-CFTR increases intracellular Ca(2+) signaling that causes enhanced calcium-dependent Cl(-) conductance in cystic fibrosis.
Biochimica et biophysica acta 2011;1812(11):1385-92.
2011: Humbert De Smedt; A Verkhratsky; S Muallem
Ca(2+) signaling mechanisms of cell survival and cell death: an introduction.
Cell calcium 2011;50(3):207-10.
2011: Djalila Mekahli; Geert Bultynck; Jan B Parys; Humbert De Smedt; Ludwig Missiaen
Endoplasmic-reticulum calcium depletion and disease.
Cold Spring Harbor perspectives in biology 2011;3(6):.
2011: Jean-Paul Decuypere; Giovanni Monaco; Geert Bultynck; Ludwig Missiaen; Humbert De Smedt; Jan B Parys
The IP(3) receptor-mitochondria connection in apoptosis and autophagy.
Biochimica et biophysica acta 2011;1813(5):1003-13.
2011: Fei Zhong; Michael W Harr; Geert Bultynck; Giovanni Monaco; Jan B Parys; Humbert De Smedt; Yi-Ping Rong; Jason K Molitoris; Minh Lam; Christopher Ryder; Shigemi Matsuyama; Clark W Distelhorst
Induction of Ca²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction.
Blood 2011;117(10):2924-34.
2011: Catheleyne D'hondt; Raf Ponsaerts; Humbert De Smedt; Mathieu Vinken; Elke De Vuyst; Marijke De Bock; Nan Wang; Vera Rogiers; Luc Leybaert; Bernard Himpens; Geert Bultynck
Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplasmic reticulum.
Cellular signalling 2011;23(2):305-16.
2011: Santeri Kiviluoto; Ludwig Missiaen; Jan B Parys; Humbert De Smedt; Jean-Paul Decuypere; Geert Bultynck
STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function.
Skeletal muscle 2011;1(1):16.
2011: Jean-Paul Decuypere; Giovanni Monaco; Ludwig Missiaen; Humbert De Smedt; Jan B Parys; Geert Bultynck
IP(3) Receptors, Mitochondria, and Ca Signaling: Implications for Aging.
Journal of aging research 2011;2011():920178.
2010: Eva Sammels; Benoit Devogelaere; Djalila Mekahli; Geert Bultynck; Ludwig Missiaen; Jan B Parys; Humbert De Smedt
Unraveling the role of polycystin-2/inositol 1,4,5-trisphosphate receptor interaction in Ca signaling.
Communicative & integrative biology 2010;3(6):530-2.
2010: Raf Ponsaerts; Elke De Vuyst; Mauricio Retamal; Catheleyne D'hondt; Dieter Vermeire; Nan Wang; Humbert De Smedt; Pascale Zimmermann; Bernard Himpens; Johan Vereecke; Luc Leybaert; Geert Bultynck
Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(11):4378-95.
2010: Jean-Paul Decuypere; Giovanni Monaco; Santeri Kiviluoto; Masatsugu Oh-hora; Tomas Luyten; Humbert De Smedt; Jan B Parys; Ludwig Missiaen; Geert Bultynck
STIM1, but not STIM2, is required for proper agonist-induced Ca2+ signaling.
Cell calcium 2010;48(2-3):161-7.
2010: Eva Sammels; Benoit Devogelaere; Djalila Mekahli; Geert Bultynck; Ludwig Missiaen; Jan B Parys; Yiqiang Cai; Stefan Somlo; Humbert De Smedt
Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain.
The Journal of biological chemistry 2010;285(24):18794-805.
2010: Eva Sammels; Jan B Parys; Ludwig Missiaen; Humbert De Smedt; Geert Bultynck
Intracellular Ca2+ storage in health and disease: a dynamic equilibrium.
Cell calcium 2010;47(4):297-314.
2009: Catheleyne D'hondt; Raf Ponsaerts; Humbert De Smedt; Geert Bultynck; Bernard Himpens
Pannexins, distant relatives of the connexin family with specific cellular functions?
BioEssays : news and reviews in molecular, cellular and developmental biology 2009;31(9):953-74.
2009: Yiping Rong; Geert Bultynck; Ademuyiwa S Aromolaran; Fei Zhong; Jan B Parys; Humbert De Smedt; Gregory A Mignery; H Llewelyn Roderick; Martin D Bootman; Clark W Distelhorst
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14397-402.
2009: Fabrizio De Mattia; Caroline Gubser; Michiel M T van Dommelen; Henk-Jan Visch; Felix Distelmaier; Antonio Postigo; Tomas Luyten; Jan B Parys; Humbert De Smedt; Geoffey L Smith; Peter H G M Willems; Frank J M van Kuppeveld
Human Golgi antiapoptotic protein modulates intracellular calcium fluxes.
Molecular biology of the cell 2009;20(16):3638-45.
2009: Veerle Vanderheyden; Takuya Wakai; Geert Bultynck; Humbert De Smedt; Jan B Parys; Rafael A Fissore
Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation.
Cell calcium 2009;46(1):56-64.
2009: Veerle Vanderheyden; Benoit Devogelaere; Ludwig Missiaen; Humbert De Smedt; Geert Bultynck; Jan B Parys
Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation.
Biochimica et biophysica acta 2009;1793(6):959-70.
2009: Karolien Van den Bergh; Herbert Hooijkaas; Daniel Blockmans; René Westhovens; Katrijn Op De Beéck; Patrick Verschueren; Diana Dufour; Joop P van de Merwe; Monika Fijak; Jörg Klug; Georges Michiels; Benoit Devogelaere; Humbert De Smedt; Rita Derua; Etienne Waelkens; Norbert Blanckaert; Xavier Bossuyt
Heterogeneous nuclear ribonucleoprotein h1, a novel nuclear autoantigen.
Clinical chemistry 2009;55(5):946-54.
2008: Junya Ito; Sook-Young Yoon; Bora Lee; Veerle Vanderheyden; Elke Vermassen; Richard Wojcikiewicz; Dominique Alfandari; Humbert De Smedt; Jan B Parys; Rafael A Fissore
Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs.
Developmental biology 2008;320(2):402-13.
2008: Yiping Rong; Ademuyiwa S Aromolaran; Geert Bultynck; Fei Zhong; Xiang Li; Karen McColl; Shigemi Matsuyama; Stephan Herlitze; H Llewelyn Roderick; Martin D Bootman; Gregory A Mignery; Jan B Parys; Humbert De Smedt; Clark W Distelhorst
Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals.
Molecular cell 2008;31(2):255-65.
2008: Benoit Devogelaere; Eva Sammels; Humbert De Smedt
The IRBIT domain adds new functions to the AHCY family.
BioEssays : news and reviews in molecular, cellular and developmental biology 2008;30(7):642-52.
2008: Tania Szado; Veerle Vanderheyden; Jan B Parys; Humbert De Smedt; Katja Rietdorf; Larissa Kotelevets; Eric Chastre; Farid Khan; Ulf Landegren; Ola Söderberg; Martin D Bootman; H Llewelyn Roderick
Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2427-32.
2008: Leen Verbert; Bora Lee; Sarah L Kocks; Zerihun Assefa; Jan B Parys; Ludwig Missiaen; Geert Callewaert; Rafael A Fissore; Humbert De Smedt; Geert Bultynck
Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling.
Biology of the cell / under the auspices of the European Cell Biology Organization 2008;100(1):39-49.
2008: Benoit Devogelaere; Leen Verbert; Jan B Parys; Ludwig Missiaen; Humbert De Smedt
The complex regulatory function of the ligand-binding domain of the inositol 1,4,5-trisphosphate receptor.
Cell calcium 2008;43(1):17-27.
2007: Benoit Devogelaere; Monique Beullens; Eva Sammels; Rita Derua; Etienne Waelkens; Johan Van Lint; Jan B Parys; Ludwig Missiaen; Mathieu Bollen; Humbert De Smedt
Protein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor.
The Biochemical journal 2007;407(2):303-11.
2007: Rachel Ashworth; Benoit Devogelaere; Jez Fabes; Richard E Tunwell; Kevin R Koh; Humbert De Smedt; Sandip Patel
Molecular and functional characterization of inositol trisphosphate receptors during early zebrafish development.
The Journal of biological chemistry 2007;282(19):13984-93.
2007: Fabrice Vandeput; Laurent Combettes; Stephen Joseph Mills; Katrien Backers; Alexandre Wohlkönig; Jan B Parys; Humbert De Smedt; Ludwig Missiaen; Geneviève Dupont; Barry V L Potter; Christophe Erneux
Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(7):1481-91.
2007: Frank Mahieu; Grzegorz Owsianik; Leen Verbert; Annelies Janssens; Humbert De Smedt; Bernd Nilius; Thomas Voets
TRPM8-independent menthol-induced Ca2+ release from endoplasmic reticulum and Golgi.
The Journal of biological chemistry 2007;282(5):3325-36.
2006: Bora Lee; Elke Vermassen; Sook-Young Yoon; Veerle Vanderheyden; Junya Ito; Dominique Alfandari; Humbert De Smedt; Jan B Parys; Rafael A Fissore
Phosphorylation of IP3R1 and the regulation of [Ca2+]i responses at fertilization: a role for the MAP kinase pathway.
Development (Cambridge, England) 2006;133(21):4355-65.
2006: Nael Nadif Kasri; Sarah L Kocks; Leen Verbert; Sébastien S Hébert; Geert Callewaert; Jan B Parys; Ludwig Missiaen; Humbert De Smedt
Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells.
Cell calcium 2006;40(1):41-51.
2006: Benoit Devogelaere; Nael Nadif Kasri; Rita Derua; Etienne Waelkens; Geert Callewaert; Ludwig Missiaen; Jan B Parys; Humbert De Smedt
Binding of IRBIT to the IP3 receptor: determinants and functional effects.
Biochemical and biophysical research communications 2006;343(1):49-56.
2006: Karolina Szlufcik; Geert Bultynck; Geert Callewaert; Ludwig Missiaen; Jan B Parys; Humbert De Smedt
The suppressor domain of inositol 1,4,5-trisphosphate receptor plays an essential role in the protection against apoptosis.
Cell calcium 2006;39(4):325-36.
2006: Nael Nadif Kasri; Katalin Török; Antony Galione; Clive Garnham; Geert Callewaert; Ludwig Missiaen; Jan B Parys; Humbert De Smedt
Endogenously bound calmodulin is essential for the function of the inositol 1,4,5-trisphosphate receptor.
The Journal of biological chemistry 2006;281(13):8332-8.
2006: Karolina Szlufcik; Ludwig Missiaen; Jan B Parys; Geert Callewaert; Humbert De Smedt
Uncoupled IP3 receptor can function as a Ca2+-leak channel: cell biological and pathological consequences.
Biology of the cell / under the auspices of the European Cell Biology Organization 2006;98(1):1-14.
2005: Jo Vanoevelen; Luc Raeymaekers; Leonard Dode; Jan B Parys; Humbert De Smedt; Geert Callewaert; Frank Wuytack; Ludwig Missiaen
Cytosolic Ca2+ signals depending on the functional state of the Golgi in HeLa cells.
Cell calcium 2005;38(5):489-95.
2005: Nael Nadif Kasri; Geert Bultynck; Jan B Parys; Geert Callewaert; Ludwig Missiaen; Humbert De Smedt
Suramin and disulfonated stilbene derivatives stimulate the Ca2+-induced Ca2+ -release mechanism in A7r5 cells.
Molecular pharmacology 2005;68(1):241-50.
2005: Huiping Tu; Zhengnan Wang; Elena Nosyreva; Humbert De Smedt; Ilya Bezprozvanny
Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms.
Biophysical journal 2005;88(2):1046-55.
2004: Kurt Van Baelen; Leonard Dode; Jo Vanoevelen; Geert Callewaert; Humbert De Smedt; Ludwig Missiaen; Jan B Parys; Luc Raeymaekers; Frank Wuytack
The Ca2+/Mn2+ pumps in the Golgi apparatus.
Biochimica et biophysica acta 2004;1742(1-3):103-12.
2004: Ludwig Missiaen; Kristel Van Acker; Kurt Van Baelen; Luc Raeymaekers; Frank Wuytack; Jan B Parys; Humbert De Smedt; Jo Vanoevelen; Leonard Dode; Rosario Rizzuto; Geert Callewaert
Calcium release from the Golgi apparatus and the endoplasmic reticulum in HeLa cells stably expressing targeted aequorin to these compartments.
Cell calcium 2004;36(6):479-87.
2004: Zerihun Assefa; Geert Bultynck; Karolina Szlufcik; Nael Nadif Kasri; Elke Vermassen; Jozef Goris; Ludwig Missiaen; Geert Callewaert; Jan B Parys; Humbert De Smedt
Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis.
The Journal of biological chemistry 2004;279(41):43227-36.
2004: Teru Jellerette; Manabu Kurokawa; Bora Lee; Christopher Malcuit; Sook-Young Yoon; Jeremy Smyth; Elke Vermassen; Humbert De Smedt; Jan B Parys; Rafael A Fissore
Cell cycle-coupled [Ca(2+)](i) oscillations in mouse zygotes and function of the inositol 1,4,5-trisphosphate receptor-1.
Developmental biology 2004;274(1):94-109.
2004: Ludwig Missiaen; Luc Raeymaekers; Leonard Dode; Jo Vanoevelen; Kurt Van Baelen; Jan B Parys; Geert Callewaert; Humbert De Smedt; Siegfried Segaert; Frank Wuytack
SPCA1 pumps and Hailey-Hailey disease.
Biochemical and biophysical research communications 2004;322(4):1204-13.
2004: Nael Nadif Kasri; Geert Bultynck; Jeremy Smyth; Karolina Szlufcik; Jan B Parys; Geert Callewaert; Ludwig Missiaen; Rafael A Fissore; Katsuhiko Mikoshiba; Humbert De Smedt
The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1,4,5-trisphosphate receptor is responsible for calmodulin inhibition, even though this inhibition requires Ca2+.
Molecular pharmacology 2004;66(2):276-84.
2004: Joelle N Chabwine; Philip Van Damme; Jan Eggermont; Humbert De Smedt; Ludwig Missiaen; Ludo Van Den Bosch; Jan B Parys; Wim Robberecht; Geert Callewaert
Long-lasting changes in GABA responsiveness in cultured neurons.
Neuroscience letters 2004;365(1):69-72.
2004: Elke Vermassen; Rafael A Fissore; Nael Nadif Kasri; Veerle Vanderheyden; Geert Callewaert; Ludwig Missiaen; Jan B Parys; Humbert De Smedt
Regulation of the phosphorylation of the inositol 1,4,5-trisphosphate receptor by protein kinase C.
Biochemical and biophysical research communications 2004;319(3):888-93.
2004: Geert Bultynck; Karolina Szlufcik; Nael Nadif Kasri; Zerihun Assefa; Geert Callewaert; Ludwig Missiaen; Jan B Parys; Humbert De Smedt
Thimerosal stimulates Ca2+ flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca2+-dependent intramolecular interaction.
The Biochemical journal 2004;381(Pt 1):87-96.
2004: Kristel Van Acker; Geert Bultynck; Daniela Rossi; Vincenzo Sorrentino; Noël Boens; Ludwig Missiaen; Humbert De Smedt; Jan B Parys; Geert Callewaert
The 12 kDa FK506-binding protein, FKBP12, modulates the Ca(2+)-flux properties of the type-3 ryanodine receptor.
Journal of cell science 2004;117(Pt 7):1129-37.
2004: Jo Vanoevelen; Luc Raeymaekers; Jan B Parys; Humbert De Smedt; Kurt Van Baelen; Geert Callewaert; Frank Wuytack; Ludwig Missiaen
Inositol trisphosphate producing agonists do not mobilize the thapsigargin-insensitive part of the endoplasmic-reticulum and Golgi Ca2+ store.
Cell calcium 2004;35(2):115-21.
2004: Nael Nadif Kasri; Anthony M Holmes; Geert Bultynck; Jan B Parys; Martin D Bootman; Katja Rietdorf; Ludwig Missiaen; Fraser McDonald; Humbert De Smedt; Stuart Conway; Andrew B Holmes; Michael J Berridge; H Llewelyn Roderick
Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.
The EMBO journal 2004;23(2):312-21.
2004: Nael Nadif Kasri; Jan B Parys; Geert Callewaert; Ludwig Missiaen; Humbert De Smedt
Calmodulin and calcium-release channels.
Biological research 2004;37(4):577-82.
2004: Geert Bultynck; Kristel Van Acker; Ludwig Missiaen; Geert Callewaert; Jan B Parys; Humbert De Smedt
[Intracellular calcium-releasing channels as cellular targets for immunophilins: a molecular, functional and structural analysis].
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2004;66(4):277-303.
2003: Geert Bultynck; Elke Vermassen; Karolina Szlufcik; Patrick De Smet; Rafael A Fissore; Geert Callewaert; Ludwig Missiaen; Humbert De Smedt; Jan B Parys
Calcineurin and intracellular Ca2+-release channels: regulation or association?
Biochemical and biophysical research communications 2003;311(4):1181-93.
2003: Valérie Dewaste; Colette Moreau; Florence De Smedt; Françoise Bex; Humbert De Smedt; Frank Wuytack; Ludwig Missiaen; Christophe Erneux
The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.
The Biochemical journal 2003;374(Pt 1):41-9.
2003: Geert Callewaert; Jan B Parys; Humbert De Smedt; Luc Raeymaekers; Frank Wuytack; Jo Vanoevelen; Kurt Van Baelen; A Simoni; Rosario Rizzuto; Ludwig Missiaen
Similar Ca(2+)-signaling properties in keratinocytes and in COS-1 cells overexpressing the secretory-pathway Ca(2+)-ATPase SPCA1.
Cell calcium 2003;34(2):157-62.
2003: Nael Nadif Kasri; Ilse Sienaert; Jan B Parys; Geert Callewaert; Ludwig Missiaen; Andreas Jeromin; Humbert De Smedt
A novel Ca2+-induced Ca2+ release mechanism in A7r5 cells regulated by calmodulin-like proteins.
The Journal of biological chemistry 2003;278(30):27548-55.
2003: Kurt Van Baelen; Jo Vanoevelen; Geert Callewaert; Jan B Parys; Humbert De Smedt; Luc Raeymaekers; Rosario Rizzuto; Ludwig Missiaen; Frank Wuytack
The contribution of the SPCA1 Ca2+ pump to the Ca2+ accumulation in the Golgi apparatus of HeLa cells assessed via RNA-mediated interference.
Biochemical and biophysical research communications 2003;306(2):430-6.
2003: Elke Vermassen; Kristel Van Acker; Willem ANNAERT; Bernard Himpens; Geert Callewaert; Ludwig Missiaen; Humbert De Smedt; Jan B Parys
Microtubule-dependent redistribution of the type-1 inositol 1,4,5-trisphosphate receptor in A7r5 smooth muscle cells.
Journal of cell science 2003;116(Pt 7):1269-77.
2003: Veerle Janssens; Jan Jordens; Ilse Stevens; Christine Van Hoof; Ellen Martens; Humbert De Smedt; Yves Engelborghs; Etienne Waelkens; Jozef Goris
Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A.
The Journal of biological chemistry 2003;278(12):10697-706.
2003: Geert Bultynck; Ilse Sienaert; Jan B Parys; Geert Callewaert; Humbert De Smedt; Noël Boens; Wim Dehaen; Ludwig Missiaen
Pharmacology of inositol trisphosphate receptors.
Pflügers Archiv : European journal of physiology 2003;445(6):629-42.
2002: Nael Nadif Kasri; Geert Bultynck; Ilse Sienaert; Geert Callewaert; Christophe Erneux; Ludwig Missiaen; Jan B Parys; Humbert De Smedt
The role of calmodulin for inositol 1,4,5-trisphosphate receptor function.
Biochimica et biophysica acta 2002;1600(1-2):19-31.
2002: Jeremy T Smyth; Allison L Abbott; Bora Lee; Ilse Sienaert; Nael Nadif Kasri; Humbert De Smedt; Tom Ducibella; Ludwig Missiaen; Jan B Parys; Rafael A Fissore
Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism.
The Journal of biological chemistry 2002;277(38):35061-70.
2002: Kristel Van Acker; Nael Nadif Kasri; Patrick De Smet; Jan B Parys; Humbert De Smedt; Ludwig Missiaen; Geert Callewaert
IP(3)-mediated Ca(2+) signals in human neuroblastoma SH-SY5Y cells with exogenous overexpression of type 3 IP(3) receptor.
Cell calcium 2002;32(2):71-81.
2002: Ilse Sienaert; Nael Nadif Kasri; Sara Vanlingen; Jan B Parys; Geert Callewaert; Ludwig Missiaen; Humbert De Smedt
Localization and function of a calmodulin-apocalmodulin-binding domain in the N-terminal part of the type 1 inositol 1,4,5-trisphosphate receptor.
The Biochemical journal 2002;365(Pt 1):269-77.
2002: Ludwig Missiaen; Jo Vanoevelen; Kristel Van Acker; Luc Raeymaekers; Jan B Parys; Geert Callewaert; Frank Wuytack; Humbert De Smedt
Ca(2+) signals in Pmr1-GFP-expressing COS-1 cells with functional endoplasmic reticulum.
Biochemical and biophysical research communications 2002;294(2):249-53.
2002: Marguerite A Stout; Luc Raeymaekers; Humbert De Smedt; Rik Casteels
Characterization of Ca2+ release from heterogeneous Ca2+ stores in sarcoplasmic reticulum isolated from arterial and gastric smooth muscle.
Canadian journal of physiology and pharmacology 2002;80(6):588-603.
2002: Geert Bultynck; Humbert De Smedt; Jan B Parys; Geert Callewaert; Ludwig Missiaen
Washing out of lipophilic compounds induces a transient increase in the passive Ca(2+) leak in permeabilized A7r5 cells.
Cell calcium 2002;31(5):229-33.
2002: Ludwig Missiaen; Jo Vanoevelen; Jan B Parys; Luc Raeymaekers; Humbert De Smedt; Geert Callewaert; Christophe Erneux; Frank Wuytack
Ca2+ uptake and release properties of a thapsigargin-insensitive nonmitochondrial Ca2+ store in A7r5 and 16HBE14o- cells.
The Journal of biological chemistry 2002;277(9):6898-902.
2001: Geert Bultynck; D Rossi; Geert Callewaert; Ludwig Missiaen; Vincenzo Sorrentino; Jan B Parys; Humbert De Smedt
The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different.
The Journal of biological chemistry 2001;276(50):47715-24.
2001: Ludwig Missiaen; Kristel Van Acker; Jan B Parys; Humbert De Smedt; Kurt Van Baelen; A Freek Weidema; Jo Vanoevelen; Luc Raeymaekers; J Renders; Geert Callewaert; Rosario Rizzuto; Frank Wuytack
Baseline cytosolic Ca2+ oscillations derived from a non-endoplasmic reticulum Ca2+ store.
The Journal of biological chemistry 2001;276(42):39161-70.
2001: M Malfait; P Gomez; T A van Veen; Jan B Parys; Humbert De Smedt; Johan Vereecke; Bernard Himpens
Effects of hyperglycemia and protein kinase C on connexin43 expression in cultured rat retinal pigment epithelial cells.
The Journal of membrane biology 2001;181(1):31-40.
2001: Sara Vanlingen; H Sipma; Patrick De Smet; Geert Callewaert; Ludwig Missiaen; Humbert De Smedt; Jan B Parys
Modulation of inositol 1,4,5-trisphosphate binding to the various inositol 1,4,5-trisphosphate receptor isoforms by thimerosal and cyclic ADP-ribose.
Biochemical pharmacology 2001;61(7):803-9.
2001: Geert Bultynck; Patrick De Smet; D Rossi; Geert Callewaert; Ludwig Missiaen; Vincenzo Sorrentino; Humbert De Smedt; Jan B Parys
Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.
The Biochemical journal 2001;354(Pt 2):413-22.
2001: Karen Maes; Ludwig Missiaen; Jan B Parys; Patrick De Smet; Ilse Sienaert; Etienne Waelkens; Geert Callewaert; Humbert De Smedt
Mapping of the ATP-binding sites on inositol 1,4,5-trisphosphate receptor type 1 and type 3 homotetramers by controlled proteolysis and photoaffinity labeling.
The Journal of biological chemistry 2001;276(5):3492-7.
2001: Ludwig Missiaen; Geert Callewaert; Humbert De Smedt; Jan B Parys
2-Aminoethoxydiphenyl borate affects the inositol 1,4,5-trisphosphate receptor, the intracellular Ca2+ pump and the non-specific Ca2+ leak from the non-mitochondrial Ca2+ stores in permeabilized A7r5 cells.
Cell calcium 2001;29(2):111-6.
2000: Geert Bultynck; Patrick De Smet; A Freek Weidema; M Ver Heyen; Karen Maes; Geert Callewaert; Ludwig Missiaen; Jan B Parys; Humbert De Smedt
Effects of the immunosuppressant FK506 on intracellular Ca2+ release and Ca2+ accumulation mechanisms.
The Journal of physiology 2000;525 Pt 3():681-93.
2000: Karen Maes; Ludwig Missiaen; Patrick De Smet; Sara Vanlingen; Geert Callewaert; Jan B Parys; Humbert De Smedt
Differential modulation of inositol 1,4,5-trisphosphate receptor type 1 and type 3 by ATP.
Cell calcium 2000;27(5):257-67.
2000: Sara Vanlingen; H Sipma; Patrick De Smet; Geert Callewaert; Ludwig Missiaen; Humbert De Smedt; Jan B Parys
Ca2+ and calmodulin differentially modulate myo-inositol 1,4, 5-trisphosphate (IP3)-binding to the recombinant ligand-binding domains of the various IP3 receptor isoforms.
The Biochemical journal 2000;346 Pt 2():275-80.
2000: Kristel Van Acker; B Bautmans; Geert Bultynck; Karen Maes; A Freek Weidema; Patrick De Smet; Jan B Parys; Humbert De Smedt; Ludwig Missiaen; Geert Callewaert
Mapping of IP(3)-mediated Ca(2+) signals in single human neuroblastoma SH-SY5Y cells: cell volume shaping the Ca(2+) signal.
Journal of neurophysiology 2000;83(2):1052-7.
2000: CE Adkins; Stephen A Morris; Humbert De Smedt; Ilse Sienaert; K Török; Colin W Taylor
Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors.
The Biochemical journal 2000;345 Pt 2():357-63.
2000: Ludwig Missiaen; Geert Callewaert; Jan B Parys; Frank Wuytack; Luc Raeymaekers; G Droogmans; Bernd Nilius; Jan Eggermont; Humbert De Smedt
[Intracellular calcium: physiology and physiopathology].
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2000;62(6):471-99.
1999: Ludwig Missiaen; Humbert De Smedt; Jan B Parys; Kristel Van Acker; Patrick De Smet; Geert Callewaert
Cytosolic Ca(2+) controls the loading dependence of IP(3)-induced Ca(2+) release.
Biochemical and biophysical research communications 1999;264(3):967-71.
1999: Patrick De Smet; Jan B Parys; Geert Callewaert; A Freek Weidema; E Hill; Humbert De Smedt; C Erneux; Vincenzo Sorrentino; Ludwig Missiaen
Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca(2+) pumps.
Cell calcium 1999;26(1-2):9-13.
1999: Patrick De Smet; Jan B Parys; Sara Vanlingen; Geert Bultynck; Geert Callewaert; Antony Galione; Humbert De Smedt; Ludwig Missiaen
The relative order of IP3 sensitivity of types 1 and 3 IP3 receptors is pH dependent.
Pflügers Archiv : European journal of physiology 1999;438(2):154-8.
1999: Ludwig Missiaen; Jan B Parys; A Freek Weidema; H Sipma; Sara Vanlingen; Patrick De Smet; Geert Callewaert; Humbert De Smedt
The bell-shaped Ca2+ dependence of the inositol 1,4, 5-trisphosphate-induced Ca2+ release is modulated by Ca2+/calmodulin.
The Journal of biological chemistry 1999;274(20):13748-51.
1999: H Sipma; Patrick De Smet; Ilse Sienaert; Sara Vanlingen; Ludwig Missiaen; Jan B Parys; Humbert De Smedt
Modulation of inositol 1,4,5-trisphosphate binding to the recombinant ligand-binding site of the type-1 inositol 1,4, 5-trisphosphate receptor by Ca2+ and calmodulin.
The Journal of biological chemistry 1999;274(17):12157-62.
1999: Ludwig Missiaen; H Sipma; Jan B Parys; Patrick De Smet; Geert Callewaert; E Hill; T V McCarthy; Humbert De Smedt
IP3-induced Ca2+ release in A7r5 vascular smooth-muscle cells represents a partial emptying of the stores and not an all-or-none Ca2+ release of separate quanta.
Pflügers Archiv : European journal of physiology 1999;437(5):691-4.
1999: Karen Maes; Ludwig Missiaen; Jan B Parys; Ilse Sienaert; Geert Bultynck; M Zizi; Patrick De Smet; Rik Casteels; Humbert De Smedt
Adenine-nucleotide binding sites on the inositol 1,4,5-trisphosphate receptor bind caffeine, but not adenophostin A or cyclic ADP-ribose.
Cell calcium 1999;25(2):143-52.
1999: Sara Vanlingen; H Sipma; Ludwig Missiaen; Humbert De Smedt; Patrick De Smet; Rik Casteels; Jan B Parys
Modulation of type 1, 2 and 3 inositol 1,4,5-trisphosphate receptors by cyclic ADP-ribose and thimerosal.
Cell calcium 1999;25(2):107-14.
1999: Ludo Van Den Bosch; Kristien Verhoeven; Humbert De Smedt; Frank Wuytack; Ludwig Missiaen; Wim Robberecht
Calcium handling proteins in isolated spinal motoneurons.
Life sciences 1999;65(15):1597-606.
1998: Felix Viana; Humbert De Smedt; Guy Droogmans; Bernd Nilius
Calcium signalling through nucleotide receptor P2Y2 in cultured human vascular endothelium.
Cell calcium 1998;24(2):117-27.
1998: Ilse Sienaert; Steven Huyghe; Jan B Parys; M Malfait; K Kunzelmann; Humbert De Smedt; G M Verleden; Ludwig Missiaen
ATP-induced Ca2+ signals in bronchial epithelial cells.
Pflügers Archiv : European journal of physiology 1998;436(1):40-8.
1998: Ludwig Missiaen; Jan B Parys; Ilse Sienaert; Karen Maes; K Kunzelmann; M Takahashi; K Tanzawa; Humbert De Smedt
Functional properties of the type-3 InsP3 receptor in 16HBE14o- bronchial mucosal cells.
The Journal of biological chemistry 1998;273(15):8983-6.
1998: Ludwig Missiaen; Jan B Parys; Humbert De Smedt; Ilse Sienaert; H Sipma; Sara Vanlingen; Karen Maes; K Kunzelmann; Rik Casteels
Inhibition of inositol trisphosphate-induced calcium release by cyclic ADP-ribose in A7r5 smooth-muscle cells and in 16HBE14o- bronchial mucosal cells.
The Biochemical journal 1998;329 ( Pt 3)():489-95.
1997: Sara Vanlingen; Jan B Parys; Ludwig Missiaen; Humbert De Smedt; Frank Wuytack; Rik Casteels
Distribution of inositol 1,4,5-trisphosphate receptor isoforms, SERCA isoforms and Ca2+ binding proteins in RBL-2H3 rat basophilic leukemia cells.
Cell calcium 1997;22(6):475-86.
1997: Ilse Sienaert; Ludwig Missiaen; Humbert De Smedt; Jan B Parys; H Sipma; Rik Casteels
Molecular and functional evidence for multiple Ca2+-binding domains in the type 1 inositol 1,4,5-trisphosphate receptor.
The Journal of biological chemistry 1997;272(41):25899-906.
1997: Ludwig Missiaen; Humbert De Smedt; Jan B Parys; H Sipma; Karen Maes; Sara Vanlingen; Ilse Sienaert; Willy Van Driessche; Rik Casteels
Synergism between hypotonically induced calcium release and fatty acyl-CoA esters induced calcium release from intracellular stores.
Cell calcium 1997;22(3):151-6.
1997: Ludwig Missiaen; Humbert De Smedt; Jan B Parys; Rik Casteels
Effect of a cytosolic Ca2+ concentration ramp on InsP3-induced Ca2+ release in A7r5 smooth-muscle cells and in EBTr cells from tracheal mucosa.
Biochemical and biophysical research communications 1997;237(2):354-8.
1997: Florence De Smedt; Ludwig Missiaen; Jan B Parys; V Vanweyenberg; Humbert De Smedt; Christophe Erneux
Isoprenylated human brain type I inositol 1,4,5-trisphosphate 5-phosphatase controls Ca2+ oscillations induced by ATP in Chinese hamster ovary cells.
The Journal of biological chemistry 1997;272(28):17367-75.
1997: Jan Eggermont; Gunnar Buyse; Thomas Voets; Jan Tytgat; Humbert De Smedt; Guy Droogmans; Bernd Nilius
Alternative splicing of ClC-6 (a member of the CIC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific.
The Biochemical journal 1997;325 ( Pt 1)():269-76.
1997: Ludwig Missiaen; Humbert De Smedt; Jan B Parys; Ilse Sienaert; H Sipma; Sara Vanlingen; Rik Casteels
Slow kinetics of inositol 1,4,5-trisphosphate-induced Ca2+ release: is the release 'quantal' or 'non-quantal'?
The Biochemical journal 1997;323 ( Pt 1)():123-30.
1997: Humbert De Smedt; Ludwig Missiaen; Jan B Parys; Robert H Henning; Ilse Sienaert; Sara Vanlingen; Antoon Gijsens; Bernard Himpens; Rik Casteels
Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.
The Biochemical journal 1997;322 ( Pt 2)():575-83.
1996: Ilse Sienaert; Humbert De Smedt; Jan B Parys; Ludwig Missiaen; Sara Vanlingen; H Sipma; Rik Casteels
Characterization of a cytosolic and a luminal Ca2+ binding site in the type I inositol 1,4,5-trisphosphate receptor.
The Journal of biological chemistry 1996;271(43):27005-12.
1996: Ludwig Missiaen; Humbert De Smedt; Jan B Parys; Luc Raeymaekers; Guy Droogmans; Ludo Van Den Bosch; Rik Casteels
Kinetics of the non-specific calcium leak from non-mitochondrial calcium stores in permeabilized A7r5 cells.
The Biochemical journal 1996;317 ( Pt 3)():849-53.
1996: Ludwig Missiaen; Humbert De Smedt; Jan B Parys; Ilse Sienaert; S Valingen; Rik Casteels
Threshold for inositol 1,4,5-trisphosphate action.
The Journal of biological chemistry 1996;271(21):12287-93.
1996: Ludwig Missiaen; Humbert De Smedt; Jan B Parys; Ilse Sienaert; Sara Vanlingen; G Droogmans; Bernd Nilius; Rik Casteels
Hypotonically induced calcium release from intracellular calcium stores.
The Journal of biological chemistry 1996;271(9):4601-4.
1996: Ludwig Missiaen; Jan B Parys; Humbert De Smedt; Ilse Sienaert; Martin D Bootman; Rik Casteels
Control of the Ca2+ release induced by myo-inositol trisphosphate and the implication in signal transduction.
Sub-cellular biochemistry 1996;26():59-95.
1996: Ludwig Missiaen; Humbert De Smedt; Jan B Parys; Ilse Sienaert; Sara Vanlingen; Rik Casteels
Effects of luminal Ca2+ on inositol trisphosphate-induced Ca2+ release: facts or artifacts?
Cell calcium 1996;19(1):91-3.
1996: Ludwig Missiaen; F X Lemaire; Jan B Parys; Humbert De Smedt; Ilse Sienaert; Rik Casteels
Initiation sites for Ca2+ signals in endothelial cells.
Pflügers Archiv : European journal of physiology 1996;431(3):318-24.
1995: Bernard Himpens; P Proot; Johan Neyts; Humbert De Smedt; E De Clercq; Rik Casteels
Human cytomegalovirus modulates the Ca2+ response to vasopressin and ATP in fibroblast cultures.
Cell calcium 1995;18(2):111-9.
1995: Ludwig Missiaen; Jan B Parys; Humbert De Smedt; F X Lemaire; Ilse Sienaert; Martin D Bootman; Rik Casteels
Slow kinetics of InsP3-induced Ca2+ release: differences between uni- and bi-directional 45Ca2+ fluxes.
Cell calcium 1995;18(2):100-10.
1995: Ludwig Missiaen; Jan B Parys; Humbert De Smedt; Ilse Sienaert; Robert H Henning; Rik Casteels
Opening up Ca2+ stores with InsP3.
Nature 1995;376(6538):299-300; author reply 301.
1995: Luc Mertens; Ludo Van Den Bosch; H Verboomen; Frank Wuytack; Humbert De Smedt; Jan Eggermont
Sequence and spatial requirements for regulated muscle-specific processing of the sarco/endoplasmic reticulum Ca(2+)-ATPase 2 gene transcript.
The Journal of biological chemistry 1995;270(18):11004-11.
1995: Jan B Parys; Ludwig Missiaen; Humbert De Smedt; Ilse Sienaert; Robert H Henning; Rik Casteels
Quantal release of calcium in permeabilized A7r5 cells is not caused by intrinsic inactivation of the inositol trisphosphate receptor.
Biochemical and biophysical research communications 1995;209(2):451-6.
1995: Jan B Parys; Humbert De Smedt; Ludwig Missiaen; Martin D Bootman; Ilse Sienaert; Rik Casteels
Rat basophilic leukemia cells as model system for inositol 1,4,5-trisphosphate receptor IV, a receptor of the type II family: functional comparison and immunological detection.
Cell calcium 1995;17(4):239-49.
1995: Humbert De Smedt; Jan B Parys
[Molecular and functional diversity of inositol triphosphate-induced Ca(2+) release].
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1995;57(5):423-58.
1994: Ludwig Missiaen; M Oike; Martin D Bootman; Humbert De Smedt; Jan B Parys; Rik Casteels
Vasopressin responses in electrically coupled A7r5 cells.
Pflügers Archiv : European journal of physiology 1994;428(3-4):283-7.
1994: Ludo Van Den Bosch; Jan Eggermont; Humbert De Smedt; Luc Mertens; Frank Wuytack; Rik Casteels
Regulation of splicing is responsible for the expression of the muscle-specific 2a isoform of the sarco/endoplasmic-reticulum Ca(2+)-ATPase.
The Biochemical journal 1994;302 ( Pt 2)():559-66.
1994: Humbert De Smedt; Ludwig Missiaen; Jan B Parys; Martin D Bootman; Luc Mertens; Ludo Van Den Bosch; Rik Casteels
Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.
The Journal of biological chemistry 1994;269(34):21691-8.
1994: Bernard Himpens; Humbert De Smedt; M Bollen
Modulation of nucleocytosolic [Ca2+] gradient in smooth muscle by protein phosphorylation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(11):879-83.
1994: Ludwig Missiaen; Jan B Parys; Humbert De Smedt; B Himpens; Rik Casteels
Inhibition of inositol trisphosphate-induced calcium release by caffeine is prevented by ATP.
The Biochemical journal 1994;300 ( Pt 1)():81-4.
1994: Ludwig Missiaen; Humbert De Smedt; Jan B Parys; Rik Casteels
Co-activation of inositol trisphosphate-induced Ca2+ release by cytosolic Ca2+ is loading-dependent.
The Journal of biological chemistry 1994;269(10):7238-42.
1994: Willy Van Driessche; Patrick De Smet; Humbert De Smedt
Poorly selective cation channels in the apical membrane of A6 cells.
Pflügers Archiv : European journal of physiology 1994;426(5):387-95.
1994: Ludwig Missiaen; Humbert De Smedt; J B Pary; M Oike; Rik Casteels
Kinetics of empty store-activated Ca2+ influx in HeLa cells.
The Journal of biological chemistry 1994;269(8):5817-23.
1994: Bernard Himpens; Humbert De Smedt; Rik Casteels
Subcellular Ca(2+)-gradients in A7r5 vascular smooth muscle.
Cell calcium 1994;15(1):55-65.
1994: Ludwig Missiaen; Jan B Parys; Humbert De Smedt; M Oike; Rik Casteels
Partial calcium release in response to submaximal inositol 1,4,5-trisphosphate receptor activation.
Molecular and cellular endocrinology 1994;98(2):147-56.
1993: Jan B Parys; Ludwig Missiaen; Humbert De Smedt; Rik Casteels
Loading dependence of inositol 1,4,5-trisphosphate-induced Ca2+ release in the clonal cell line A7r5. Implications for the mechanism of quantal Ca2+ release.
The Journal of biological chemistry 1993;268(33):25206-12.
1993: Ludwig Missiaen; Jan B Parys; Martin D Bootman; Humbert De Smedt; G Droogmans; Rik Casteels
Normal Ca2+ signalling in glutathione-depleted and dithiothreitol-treated HeLa cells.
Pflügers Archiv : European journal of physiology 1993;423(5-6):480-4.
1993: S De Jaegere; Frank Wuytack; Humbert De Smedt; Ludo Van Den Bosch; Rik Casteels
Alternative processing of the gene transcripts encoding a plasma-membrane and a sarco/endoplasmic reticulum Ca2+ pump during differentiation of BC3H1 muscle cells.
Biochimica et biophysica acta 1993;1173(2):188-94.
1993: M Tshipamba; Humbert De Smedt; Ludwig Missiaen; Bernard Himpens; Ludo Van Den Bosch; R Borghgraef
Ca2+ dependence of inositol 1,4,5-trisphosphate-induced Ca2+ release in renal epithelial LLC-PK1 cells.
Journal of cellular physiology 1993;155(1):96-103.
1992: Ludwig Missiaen; Humbert De Smedt; Guy Droogmans; Rik Casteels
2,5-Di-(tert-butyl)-1,4-benzohydroquinone and cyclopiazonic acid decrease the Ca2+ permeability of endoplasmic reticulum.
European journal of pharmacology 1992;227(4):391-4.
1992: Frank Wuytack; Luc Raeymaekers; Humbert De Smedt; J A Eggermont; Ludwig Missiaen; Ludo Van Den Bosch; S De Jaegere; H Verboomen; L Plessers; Rik Casteels
Ca(2+)-transport ATPases and their regulation in muscle and brain.
Annals of the New York Academy of Sciences 1992;671():82-91.
1992: H Verboomen; Frank Wuytack; Humbert De Smedt; Bernard Himpens; Rik Casteels
Functional difference between SERCA2a and SERCA2b Ca2+ pumps and their modulation by phospholamban.
The Biochemical journal 1992;286 ( Pt 2)():591-5.
1992: J Lehotsky; Luc Raeymaekers; Ludwig Missiaen; Frank Wuytack; Humbert De Smedt; Rik Casteels
Stimulation of the catalytic cycle of the Ca2+ pump of porcine plasma-membranes by negatively charged phospholipids.
Biochimica et biophysica acta 1992;1105(1):118-24.
1992: K P Heirwegh; Humbert De Smedt; M Vermeir
Analysis of membrane-bound acceptors. A correction function for non-specific accumulation of poorly water-soluble hydrophobic or amphipathic ligands based on the ligand partition concept.
Biochemical pharmacology 1992;43(4):701-4.
1991: Ludo Van Den Bosch; Humbert De Smedt; R Borghgraef
Influence of PMA and a low extracellular Ca2+ concentration on the development of the Na(+)-dependent hexose carrier in LLC-PK1 cells.
Biochimica et biophysica acta 1991;1092(2):244-50.
1991: Humbert De Smedt; J A Eggermont; Frank Wuytack; Jan B Parys; Ludo Van Den Bosch; Ludwig Missiaen; J Verbis; Rik Casteels
Isoform switching of the sarco(endo)plasmic reticulum Ca2+ pump during differentiation of BC3H1 myoblasts.
The Journal of biological chemistry 1991;266(11):7092-5.
1991: Ludwig Missiaen; Humbert De Smedt; Guy Droogmans; I Declerck; L Plessers; Rik Casteels
Uptake characteristics of the InsP3-sensitive and -insensitive Ca2+ pools in porcine aortic smooth-muscle cells: different Ca2+ sensitivity of the Ca2(+)-uptake mechanism.
Biochemical and biophysical research communications 1991;174(3):1183-8.
1991: Humbert De Smedt; Jan B Parys; Bernard Himpens; Ludwig Missiaen; R Borghgraef
Changes in the mechanism of Ca2(+) mobilization during the differentiation of BC3H1 muscle cells.
The Biochemical journal 1991;273(Pt 1)():219-23.
1990: Ludo Van Den Bosch; Humbert De Smedt; R Borghgraef
Development of the Na(+)-dependent hexose carrier in LLC-PK1 cells is dependent on microtubules.
Biochimica et biophysica acta 1990;1030(2):223-30.
1990: Jan B Parys; Humbert De Smedt; Ludo Van Den Bosch; J Geuns; R Borghgraef
Regulation of the Na(+)-dependent and the Na(+)-independent polyamine transporters in renal epithelial cells (LLC-PK1).
Journal of cellular physiology 1990;144(3):365-75.
1990: Ludwig Missiaen; I Declerck; Guy Droogmans; L Plessers; Humbert De Smedt; Luc Raeymaekers; Rik Casteels
Agonist-dependent Ca2+ and Mn2+ entry dependent on state of filling of Ca2+ stores in aortic smooth muscle cells of the rat.
The Journal of physiology 1990;427():171-86.
1990: Ludwig Missiaen; Humbert De Smedt; Guy Droogmans; Frank Wuytack; Luc Raeymaekers; Rik Casteels
Ruthenium red and compound 48/80 inhibit the smooth-muscle plasma-membrane Ca2+ pump via interaction with associated polyphosphoinositides.
Biochimica et biophysica acta 1990;1023(3):449-54.
1990: Ludo Van Den Bosch; Humbert De Smedt; Ludwig Missiaen; Jan B Parys; R Borghgraef
Transport systems for polyamines in the established renal cell line LLC-PK. Polarized expression of an Na(+)-dependent transporter.
The Biochemical journal 1990;265(2):609-12.
1989: Ludo Van Den Bosch; Humbert De Smedt; R Borghgraef
Different pattern of differentiation in two LLC-PK1 clones.
Journal of cellular physiology 1989;141(3):483-9.
1989: Ludwig Missiaen; Luc Raeymaekers; Frank Wuytack; Mathias Vrolix; Humbert De Smedt; Rik Casteels
Phospholipid-protein interactions of the plasma-membrane Ca2+-transporting ATPase. Evidence for a tissue-dependent functional difference.
The Biochemical journal 1989;263(3):687-94.
1989: Ludwig Missiaen; Frank Wuytack; Humbert De Smedt; Frederic Amant; Rik Casteels
AIF4-induced inhibition of the ATPase activity, the Ca2+-transport activity and the phosphoprotein-intermediate formation of plasma-membrane and endo(sarco)plasmic-reticulum Ca2+-transport ATPases in different tissues. Evidence for a tissue-dependent functional difference.
The Biochemical journal 1989;261(2):655-60.
1989: Humbert De Smedt; Ludo Van Den Bosch; J Geuns; R Borghgraef
Polyamine transport systems in the LLC-PK1 renal epithelial established cell line.
Biochimica et biophysica acta 1989;1012(2):171-7.
1989: K P Heirwegh; J A Meuwissen; Philippe E Van den Steen; Humbert De Smedt
Modelling of chemical reactions catalysed by membrane-bound enzymes. Determination and significance of the kinetic constants.
Biochimica et biophysica acta 1989;995(2):151-9.
1989: Ludo Van Den Bosch; Humbert De Smedt; R Borghgraef
Characteristics of Na+-dependent hexose transport in OK, an established renal epithelial cell line.
Biochimica et biophysica acta 1989;979(1):91-8.
1988: K P Heirwegh; J A Meuwissen; M Vermeir; Humbert De Smedt
Liposomes as carriers of poorly water-soluble substrates: linear modelling of membrane systems with catalytic or binding sites of different facedness. Significance of experimental membrane partition coefficients and of kinetic and equilibrium parameters.
The Biochemical journal 1988;254(1):101-8.
1988: Ludwig Missiaen; Frank Wuytack; Humbert De Smedt; Mathias Vrolix; Rik Casteels
AlF4- reversibly inhibits 'P'-type cation-transport ATPases, possibly by interacting with the phosphate-binding site of the ATPase.
The Biochemical journal 1988;253(3):827-33.
1988: Humbert De Smedt; Ludo Van Den Bosch; Jan B Parys; Frank Wuytack; R Borghgraef
Calcium transport systems in renal epithelial established cell lines.
Progress in clinical and biological research 1988;252():255-60.
1987: Humbert De Smedt; Jan B Parys; R Borghgraef
Calmodulin and calmodulin-binding proteins in the renal brush border.
Biochimica et biophysica acta 1987;929(1):103-13.
1986: Jan B Parys; Humbert De Smedt; R Borghgraef
Calcium transport systems in the LLC-PK1 renal epithelial established cell line.
Biochimica et biophysica acta 1986;888(1):70-81.
1985: Jan B Parys; Humbert De Smedt; P Vandenberghe; R Borghgraef
Characterization of ATP-driven calcium uptake in renal basal-lateral and renal endoplasmic reticulum membrane vesicles.
Cell calcium 1985;6(5):413-29.
1984: Humbert De Smedt; Jan B Parys; Frank Wuytack; R Borghgraef
Calcium-induced phosphorylations and [125I]calmodulin binding in renal membrane preparations.
Biochimica et biophysica acta 1984;776(1):122-32.
1983: Humbert De Smedt; Jan B Parys; R Borghgraef; Frank Wuytack
Phosphorylated intermediates of (Ca2+ + Mg2+)-ATPase and alkaline phosphatase in renal plasma membranes.
Biochimica et biophysica acta 1983;728(3):409-18.
1981: Humbert De Smedt; Jan B Parys; R Borghgraef; Frank Wuytack
Calmodulin stimulation of renal (Ca2+ + Mg2+)-ATPase.
FEBS letters 1981;131(1):60-2.
1981: H Gögelein; Humbert De Smedt; W Van Driessche; R Borghgraef
The effect of lanthanum on alamethicin channels in black lipid bilayers.
Biochimica et biophysica acta 1981;640(1):185-94.
1980: N Paulussen-Noterman; Humbert De Smedt; R Borghgraef
Temperature dependence of the interaction of lipophilic drugs with (Na+ + K+)-ATPase from pig kidney [proceedings].
Archives internationales de physiologie et de biochimie 1980;88(1):P17-P18.