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Magda De Smedt

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Inge Van de Walle; Bart Vandekerckhove; Els Waegemans; Tao Wang; Jelle De Medts; Magda De Smedt; Greet De Smet; Thomas Gridley; Tessa Kerre; Ute Koch; Georges Leclercq; Jean Plum; Freddy Radtke; Sylvia Snauwaert; Tom Taghon
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.
Veerle De Colvenaer; Magda De Smedt; Maarten Delforche; Jean Plum; Tom Taghon; Sylvie Taveirne; Bart Vandekerckhove; Louis Boon; Georges Leclercq
CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation.
Magda De Smedt; Georges Leclercq; Bart Vandekerckhove; Tessa Kerre; Tom Taghon; Jean Plum
T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells.

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All Publications

2013: Inge Van de Walle; Bart Vandekerckhove; Els Waegemans; Tao Wang; Jelle De Medts; Magda De Smedt; Greet De Smet; Thomas Gridley; Tessa Kerre; Ute Koch; Georges Leclercq; Jean Plum; Freddy Radtke; Sylvia Snauwaert; Tom Taghon
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.
The Journal of experimental medicine 2013;210(4):683-97.
2011: Veerle De Colvenaer; Magda De Smedt; Maarten Delforche; Jean Plum; Tom Taghon; Sylvie Taveirne; Bart Vandekerckhove; Louis Boon; Georges Leclercq
CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation.
Immunology and cell biology 2011;89(7):803-11.
2011: Magda De Smedt; Georges Leclercq; Bart Vandekerckhove; Tessa Kerre; Tom Taghon; Jean Plum
T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells.
Haematologica 2011;96(5):646-54.
2011: Inge Van de Walle; Greet De Smet; Martina Gärtner; Magda De Smedt; Els Waegemans; Bart Vandekerckhove; Georges Leclercq; Jean Plum; Jon C Aster; Irwin D Bernstein; Cynthia J Guidos; Bruno Kyewski; Tom Taghon
Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.
Blood 2011;117(17):4449-59.
2009: Stefanie Van Coppernolle; Greet Verstichel; Frank Timmermans; Imke Velghe; David Vermijlen; Magda De Smedt; Georges Leclercq; Jean Plum; Tom Taghon; Bart Vandekerckhove; Tessa C C Kerre
Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):4859-70.
2009: Frank Timmermans; Imke Velghe; Lieve Vanwalleghem; Magda De Smedt; Stefanie Van Coppernolle; Tom Taghon; Harry D Moore; Georges Leclercq; Anton Langerak; Tessa C C Kerre; Jean Plum; Bart Vandekerckhove
Generation of T cells from human embryonic stem cell-derived hematopoietic zones.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):6879-88.
2009: Tom Taghon; Inge Van de Walle; Greet De Smet; Magda De Smedt; Georges Leclercq; Bart Vandekerckhove; Jean Plum
Notch signaling is required for proliferation but not for differentiation at a well-defined beta-selection checkpoint during human T-cell development.
Blood 2009;113(14):3254-63.
2009: Inge Van de Walle; Greet De Smet; Magda De Smedt; Bart Vandekerckhove; Georges Leclercq; Jean Plum; Tom Taghon
An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells.
Blood 2009;113(13):2988-98.
2008: Jean Plum; Magda De Smedt; Georges Leclercq; Tom Taghon; Tessa C C Kerre; Bart Vandekerckhove
Human intrathymic development: a selective approach.
Seminars in immunopathology 2008;30(4):411-23.
2007: Magda De Smedt; Tom Taghon; Inge Van de Walle; Greet De Smet; Georges Leclercq; Jean Plum
Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells.
Blood 2007;110(7):2696-703.
2007: Kaatje Smits; Magda De Smedt; Evelien Naessens; Greet De Smet; Veronique Stove; Tom Taghon; Jean Plum; Bruno Verhasselt
Tumor necrosis factor promotes T-cell at the expense of B-cell lymphoid development from cultured human CD34+ cord blood cells.
Experimental hematology 2007;35(8):1272-8.
2007: Frank Timmermans; Filip Van Hauwermeiren; Magda De Smedt; Robrecht Raedt; Frank Plasschaert; Marc L De Buyzere; Thierry C Gillebert; Jean Plum; Bart Vandekerckhove
Endothelial outgrowth cells are not derived from CD133+ cells or CD45+ hematopoietic precursors.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(7):1572-9.
2007: Inge Hoebeke; Magda De Smedt; Frank Stolz; Karin Pike-Overzet; Frank Staal; Jean Plum; Georges Leclercq
T-, B- and NK-lymphoid, but not myeloid cells arise from human CD34(+)CD38(-)CD7(+) common lymphoid progenitors expressing lymphoid-specific genes.
Leukemia 2007;21(2):311-9.
2007: Katrien Vanheusden; Stefanie Van Coppernolle; Magda De Smedt; Jean Plum; Bart Vandekerckhove
In vitro expanded cells contributing to rapid severe combined immunodeficient repopulation activity are CD34+38-33+90+45RA-.
Stem cells (Dayton, Ohio) 2007;25(1):107-14.
2006: Inge Hoebeke; Magda De Smedt; Inge Van de Walle; Katia Reynvoet; Greet De Smet; Jean Plum; Georges Leclercq
Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hematopoietic stem cells.
Blood 2006;107(7):2879-81.
2006: Mikaël J Pittet; Asma Gati; Frédérique-Anne Le Gal; Gilles Bioley; Philippe Guillaume; Magda De Smedt; Jean Plum; Daniel E Speiser; Jean-Charles Cerottini; Pierre-Yves Dietrich; Pedro Romero; Alfred Zippelius
Ex vivo characterization of allo-MHC-restricted T cells specific for a single MHC-peptide complex.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2330-6.
2005: Magda De Smedt; Inge Hoebeke; Katia Reynvoet; Georges Leclercq; Jean Plum
Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment.
Blood 2005;106(10):3498-506.
2004: Magda De Smedt; Inge Hoebeke; Jean Plum
Human bone marrow CD34+ progenitor cells mature to T cells on OP9-DL1 stromal cell line without thymus microenvironment.
Blood cells, molecules & diseases 2004;33(3):227-32.
2004: Alfred Zippelius; Gilles Bioley; Frédérique-Anne Le Gal; Nathalie Rufer; Marlene Brandes; Pascal Batard; Magda De Smedt; Jean Plum; Daniel E Speiser; Jean-Charles Cerottini; Pierre-Yves Dietrich; Pedro Romero; Mikaël J Pittet
Human thymus exports naive CD8 T cells that can home to nonlymphoid tissues.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):2773-7.
2003: Tom Taghon; K Thys; Magda De Smedt; Floor Weerkamp; Frank Staal; Jean Plum; Georges Leclercq
Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development.
Leukemia 2003;17(6):1157-63.
2002: Magda De Smedt; Katia Reynvoet; Tessa C C Kerre; Tom Taghon; Bruno Verhasselt; Bart Vandekerckhove; Georges Leclercq; Jean Plum
Active form of Notch imposes T cell fate in human progenitor cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):3021-9.
2002: Tessa C C Kerre; Greet De Smet; Magda De Smedt; Alfred Zippelius; Mikaël J Pittet; Anton Langerak; José De Bosscher; Fritz Offner; Bart Vandekerckhove; Jean Plum
Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34(+) cells.
Blood 2002;99(5):1620-6.
2002: Alfred Zippelius; Mikaël J Pittet; Pascal Batard; Nathalie Rufer; Magda De Smedt; Philippe Guillaume; Kim Ellefsen; Danila Valmori; Danielle Liénard; Jean Plum; H Robson MacDonald; Daniel E Speiser; Jean-Charles Cerottini; Pedro Romero
Thymic selection generates a large T cell pool recognizing a self-peptide in humans.
The Journal of experimental medicine 2002;195(4):485-94.
2002: Tom Taghon; Frank Stolz; Magda De Smedt; Maggy Cnockaert; Bruno Verhasselt; Jean Plum; Georges Leclercq
HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor.
Blood 2002;99(4):1197-204.
2001: Tom Taghon; Magda De Smedt; Frank Stolz; M Cnockaert; Jean Plum; Georges Leclercq
Enforced expression of GATA-3 severely reduces human thymic cellularity.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4468-75.
2001: Tessa C C Kerre; Greet De Smet; Magda De Smedt; Fritz Offner; J De Bosscher; Jean Plum; Bart Vandekerckhove
Both CD34+38+ and CD34+38- cells home specifically to the bone marrow of NOD/LtSZ scid/scid mice but show different kinetics in expansion.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):3692-8.
2000: Bruno Verhasselt; Evelien Naessens; Magda De Smedt; Jean Plum
Efficiency of transgenic T cell generation from gene-marked cultured human CD34+ cord blood cells is determined by their maturity and the cytokines present in the culture medium.
Gene therapy 2000;7(10):830-6.
2000: SF Weekx; Hans-Willem Snoeck; Fritz Offner; Magda De Smedt; Dirk R Van Bockstaele; Griet Nijs; Marc Lenjou; Adriaan C Moulijn; Inez E Rodrigus; Zwi N Berneman; Jean Plum
Generation of T cells from adult human hematopoietic stem cells and progenitors in a fetal thymic organ culture system: stimulation by tumor necrosis factor-alpha.
Blood 2000;95(9):2806-12.
2000: Magda De Smedt; Bruno Verhasselt; Tessa C C Kerre; D Vanhecke; Evelien Naessens; Georges Leclercq; J C Renauld; J Van Snick; Jean Plum
Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1761-7.
2000: Jean Plum; Magda De Smedt; Bruno Verhasselt; Tessa C C Kerre; D Vanhecke; Bart Vandekerckhove; Georges Leclercq
Human T lymphopoiesis. In vitro and in vivo study models.
Annals of the New York Academy of Sciences 2000;917():724-31.
1999: Bruno Verhasselt; Tessa C C Kerre; Evelien Naessens; D Vanhecke; Magda De Smedt; Bart Vandekerckhove; Jean Plum
Thymic repopulation by CD34(+) human cord blood cells after expansion in stroma-free culture.
Blood 1999;94(11):3644-52.
1999: Bruno Verhasselt; Evelien Naessens; Chris Verhofstede; Magda De Smedt; S Schollen; Tessa C C Kerre; D Vanhecke; Jean Plum
Human immunodeficiency virus nef gene expression affects generation and function of human T cells, but not dendritic cells.
Blood 1999;94(8):2809-18.
1999: SF Weekx; Jean Plum; Philip Van Cauwelaert; Marc Lenjou; Griet Nijs; Magda De Smedt; M Vanhove; Philip Muylaert; Dirk R Van Bockstaele; Zwi N Berneman; Hans-Willem Snoeck
Developmentally regulated responsiveness to transforming growth factor-beta is correlated with functional differences between human adult and fetal primitive hematopoietic progenitor cells.
Leukemia 1999;13(8):1266-72.
1999: Fritz Offner; Tessa C C Kerre; Magda De Smedt; Jean Plum
Bone marrow CD34 cells generate fewer T cells in vitro with increasing age and following chemotherapy.
British journal of haematology 1999;104(4):801-8.
1999: Jean Plum; Magda De Smedt; Bruno Verhasselt; Fritz Offner; Tessa C C Kerre; D Vanhecke; Georges Leclercq; Bart Vandekerckhove
In vitro intrathymic differentiation kinetics of human fetal liver CD34+CD38- progenitors reveals a phenotypically defined dendritic/T-NK precursor split.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(1):60-8.
1998: SF Weekx; Dirk R Van Bockstaele; Jean Plum; Adriaan C Moulijn; Inez E Rodrigus; Filip Lardon; Magda De Smedt; Griet Nijs; Marc Lenjou; P Loquet; Zwi N Berneman; Hans-Willem Snoeck
CD34++ CD38- and CD34+ CD38+ human hematopoietic progenitors from fetal liver, cord blood, and adult bone marrow respond differently to hematopoietic cytokines depending on the ontogenic source.
Experimental hematology 1998;26(11):1034-42.
1998: Bruno Verhasselt; Magda De Smedt; Rita Verhelst; Evelien Naessens; Jean Plum
Retrovirally transduced CD34++ human cord blood cells generate T cells expressing high levels of the retroviral encoded green fluorescent protein marker in vitro.
Blood 1998;91(2):431-40.
1997: D Vanhecke; Bruno Verhasselt; Magda De Smedt; Georges Leclercq; Jean Plum; Bart Vandekerckhove
Human thymocytes become lineage committed at an early postselection CD69+ stage, before the onset of functional maturation.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):5973-83.
1997: D Vanhecke; Bruno Verhasselt; Magda De Smedt; B De Paepe; Georges Leclercq; Jean Plum; Bart Vandekerckhove
MHC class II molecules are required for initiation of positive selection but not during terminal differentiation of human CD4 single positive thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3730-7.
1996: Jean Plum; Magda De Smedt; Georges Leclercq; Bruno Verhasselt; Bart Vandekerckhove
Interleukin-7 is a critical growth factor in early human T-cell development.
Blood 1996;88(11):4239-45.
1995: Jean Plum; Magda De Smedt; Georges Leclercq; Bart Vandekerckhove
Influence of TGF-beta on murine thymocyte development in fetal thymus organ culture.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(11):5789-98.
1995: Georges Leclercq; Magda De Smedt; Jean Plum
Cytokine dependence of V gamma 3 thymocytes: mature but not immature V gamma 3 cells require endogenous IL-2 and IL-7 to survive--evidence for cytokine redundancy.
International immunology 1995;7(5):843-51.
1994: Jean Plum; Magda De Smedt; Marie-Paule Defresne; Georges Leclercq; Bart Vandekerckhove
Human CD34+ fetal liver stem cells differentiate to T cells in a mouse thymic microenvironment.
Blood 1994;84(5):1587-93.
1994: Magda De Smedt; Georges Leclercq; Bart Vandekerckhove; Jean Plum
Human fetal liver cells differentiate into thymocytes in chimeric mouse fetal thymus organ culture.
Advances in experimental medicine and biology 1994;355():27-31.