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Alex de Vos

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L M Kager; J C M Meijers; J J T H Roelofs; M Schouten; Alex F de Vos; C T Esmon; B Isermann; Cornelis van 't Veer; C W Wieland; T van der Poll
The endothelial protein C receptor and activated protein C play a limited role in host defense during experimental tuberculosis.
Dana C Blok; Onno J de Boer; Alex F de Vos; Sandrine Florquin; Koenraad F van der Sluijs; Cornelis van 't Veer; Tom van der Poll
Limited anti-inflammatory role for interleukin-1 receptor like 1 (ST2) in the host response to murine postinfluenza pneumococcal pneumonia.
Miriam H P van Lieshout; Cornelis van 't Veer; Catharina W Wieland; Dana C Blok; Alex F de Vos; Tom van der Poll
Differential roles of MyD88 and TRIF in hematopoietic and resident cells during murine gram-negative pneumonia.

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2013: L M Kager; J C M Meijers; J J T H Roelofs; M Schouten; Alex F de Vos; C T Esmon; B Isermann; Cornelis van 't Veer; C W Wieland; T van der Poll
The endothelial protein C receptor and activated protein C play a limited role in host defense during experimental tuberculosis.
Thrombosis and haemostasis 2013;109(4):726-37.
2013: Dana C Blok; Onno J de Boer; Alex F de Vos; Sandrine Florquin; Koenraad F van der Sluijs; Cornelis van 't Veer; Tom van der Poll
Limited anti-inflammatory role for interleukin-1 receptor like 1 (ST2) in the host response to murine postinfluenza pneumococcal pneumonia.
PloS one 2013;8(3):e58191.
2012: Miriam H P van Lieshout; Cornelis van 't Veer; Catharina W Wieland; Dana C Blok; Alex F de Vos; Tom van der Poll
Differential roles of MyD88 and TRIF in hematopoietic and resident cells during murine gram-negative pneumonia.
The Journal of infectious diseases 2012;206(9):1415-23.
2012: Gerritje J W van der Windt; Cornelis Van't Veer; Dana C Blok; Alex F de Vos; Richard A Flavell; Sandrine Florquin; Jacobien J Hoogerwerf; Koichi S Kobayashi; Adriana J J Lammers; Tom van der Poll
Interleukin 1 receptor-associated kinase m impairs host defense during pneumococcal pneumonia.
The Journal of infectious diseases 2012;205(12):1849-57.
2012: Ahmed Achouiti; Alex F de Vos; Sandrine Florquin; Tijmen J Hommes; Marc Röhm; Johannes Roth; Constantin F Urban; Cornelis van 't Veer; Marieke A D van Zoelen; Thomas Vogl; Tom van der Poll
Myeloid-related protein-14 contributes to protective immunity in gram-negative pneumonia derived sepsis.
PLoS pathogens 2012;8(10):e1002987.
2012: Jacobien J Hoogerwerf; Koichi S Kobayashi; Gerritje J W van der Windt; Cornelis van 't Veer; Dana C Blok; Alex F de Vos; Richard A Flavell; Sandrine Florquin; Arie J Hoogendijk; Tom van der Poll
Interleukin-1 receptor-associated kinase M-deficient mice demonstrate an improved host defense during Gram-negative pneumonia.
Molecular medicine (Cambridge, Mass.) 2012;18():1067-75.
2011: Cornelis van 't Veer; Alex F de Vos; Sandrine Florquin; Daniëlle Kruijswijk; Petra S van den Pangaart; Tom van der Poll
Delineation of the role of Toll-like receptor signaling during peritonitis by a gradually growing pathogenic Escherichia coli.
The Journal of biological chemistry 2011;286(42):36603-18.
2011: Gerritje J W van der Windt; Arie J Hoogendijk; Marcel Schouten; Tijmen J Hommes; Alex F de Vos; Sandrine Florquin; Tom van der Poll
Osteopontin impairs host defense during pneumococcal pneumonia.
The Journal of infectious diseases 2011;203(12):1850-8.
2011: Jacobien J Hoogerwerf; Masja Leendertse; Catharina W Wieland; Alex F de Vos; J Daan de Boer; Sandrine Florquin; Tom van der Poll
Loss of suppression of tumorigenicity 2 (ST2) gene reverses sepsis-induced inhibition of lung host defense in mice.
American journal of respiratory and critical care medicine 2011;183(7):932-40.
2011: David J van Westerloo; Goda Choi; Ester C Löwenberg; Jasper Truijen; Alex F de Vos; Erik Endert; Joost C M Meijers; Lu Zhou; Manuel P F L Pereira; Karla C S Queiroz; Sander H Diks; Marcel Levi; Maikel Peppelenbosch; Tom van der Poll
Acute stress elicited by bungee jumping suppresses human innate immunity.
Molecular medicine (Cambridge, Mass.) 2011;17(3-4):180-8.
2011: Rosalie Molenaar; Marlene Knippenberg; Gera Goverse; Brenda J Olivier; Alex F de Vos; Tom O'Toole; Reina E Mebius
Expression of retinaldehyde dehydrogenase enzymes in mucosal dendritic cells and gut-draining lymph node stromal cells is controlled by dietary vitamin A.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):1934-42.
2011: Henrike Veninga; Feng-Qi An; Alex M de Bruin; Alex F de Vos; Robert M Hoek; M Edward Medof; Tom van der Poll; René A W van Lier; Jörg Hamann
A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense.
PloS one 2011;6(10):e24431.
2010: G J W van der Windt; J J Hoogerwerf; Alex F de Vos; Sandrine Florquin; Tom van der Poll
Osteopontin promotes host defense during Klebsiella pneumoniae-induced pneumonia.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(6):1337-45.
2010: Gerritje J W van der Windt; Sandrine Florquin; Alex F de Vos; Cornelis van't Veer; Karla C S Queiroz; Jiurong Liang; Dianhua Jiang; Paul W Noble; Tom van der Poll
CD44 deficiency is associated with increased bacterial clearance but enhanced lung inflammation during Gram-negative pneumonia.
The American journal of pathology 2010;177(5):2483-94.
2010: A A Anas; W Joost Wiersinga; Alex F de Vos; Tom van der Poll
Recent insights into the pathogenesis of bacterial sepsis.
The Netherlands journal of medicine 2010;68(4):147-52.
2010: Jacobien J Hoogerwerf; Alex F de Vos; Cornelis van't Veer; Paul Bresser; Anita de Boer; Michael W T Tanck; Christian Draing; jaring s. van der zee; Tom van der Poll
Priming of alveolar macrophages upon instillation of lipopolysaccharide in the human lung.
American journal of respiratory cell and molecular biology 2010;42(3):349-56.
2010: Masja Leendertse; Rob Willems; Roelof Flierman; Alex F de Vos; Marc J M Bonten; Tom van der Poll
The complement system facilitates clearance of Enterococcus faecium during murine peritonitis.
The Journal of infectious diseases 2010;201(4):544-52.
2010: Jacobien J Hoogerwerf; Marieke A van Zoelen; W Joost Wiersinga; Cornelis van 't Veer; Alex F de Vos; Anita de Boer; Marcus J Schultz; Berend Hooibrink; Evert de Jonge; Tom van der Poll
Gene expression profiling of apoptosis regulators in patients with sepsis.
Journal of innate immunity 2010;2(5):461-8.
2010: Adam A Anas; Joppe W R Hovius; Cornelis van 't Veer; Tom van der Poll; Alex F de Vos
Role of CD14 in a mouse model of acute lung inflammation induced by different lipopolysaccharide chemotypes.
PloS one 2010;5(4):e10183.
2010: Adam Anas; Tom van der Poll; Alex F de Vos
Role of CD14 in lung inflammation and infection.
Critical care (London, England) 2010;14(2):209.
2009: Marieke A D van Zoelen; Ann-Marie Schmidt; Sandrine Florquin; Joost C Meijers; Regina de Beer; Alex F de Vos; Peter P Nawroth; Angelika Bierhaus; Tom van der Poll
Receptor for advanced glycation end products facilitates host defense during Escherichia coli-induced abdominal sepsis in mice.
The Journal of infectious diseases 2009;200(5):765-73.
2009: Joppe Hovius; Maarten F Bijlsma; Gerritje J W van der Windt; W Joost Wiersinga; Bastiaan J D Boukens; Jeroen Coumou; Anneke Oei; Regina de Beer; Alex F de Vos; Cornelis van 't Veer; Alje P Van Dam; Penghua Wang; Erol Fikrig; Marcel M Levi; Joris J T H Roelofs; Tom van der Poll
The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi.
PLoS pathogens 2009;5(5):e1000447.
2009: Marieke A D van Zoelen; Marcel Schouten; Alex F de Vos; Sandrine Florquin; Joost C M Meijers; Peter P Nawroth; Angelika Bierhaus; Tom van der Poll
The receptor for advanced glycation end products impairs host defense in pneumococcal pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4349-56.
2009: Jacobien J Hoogerwerf; Alex F de Vos; Marcel Levi; Paul Bresser; jaring s. van der zee; Christian Draing; Sonja Von Aulock; Tom van der Poll
Activation of coagulation and inhibition of fibrinolysis in the human lung on bronchial instillation of lipoteichoic acid and lipopolysaccharide.
Critical care medicine 2009;37(2):619-25.
2009: Mark C Dessing; Robert A Hirst; Alex F de Vos; Tom van der Poll
Role of Toll-like receptors 2 and 4 in pulmonary inflammation and injury induced by pneumolysin in mice.
PloS one 2009;4(11):e7993.
2008: Henrike Veninga; Susann Becker; Robert M Hoek; Manja Wobus; Elke Wandel; Jos van der Kaa; Martin van der Valk; Alex F de Vos; Hannelore Haase; Bronwyn Owens; Tom van der Poll; René A W van Lier; Sjef Verbeek; Gabriela Aust; Jörg Hamann
Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6574-83.
2008: W Joost Wiersinga; Alex F de Vos; Catharina W Wieland; Masja Leendertse; Joris J T H Roelofs; Tom van der Poll
CD14 impairs host defense against gram-negative sepsis caused by Burkholderia pseudomallei in mice.
The Journal of infectious diseases 2008;198(9):1388-97.
2008: Jacobien J Hoogerwerf; Alex F de Vos; Paul Bresser; jaring s. van der zee; Jennie M Pater; Anita de Boer; Michael W T Tanck; Daniel L Lundell; Chung Her-Jenh; Christian Draing; Sonja Von Aulock; Tom van der Poll
Lung inflammation induced by lipoteichoic acid or lipopolysaccharide in humans.
American journal of respiratory and critical care medicine 2008;178(1):34-41.
2008: Masja Leendertse; Rob Willems; Ida A J Giebelen; Petra S van den Pangaart; W Joost Wiersinga; Alex F de Vos; Sandrine Florquin; Marc J M Bonten; Tom van der Poll
TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4865-74.
2008: Marieke A D van Zoelen; Sandrine Florquin; Joost C M Meijers; Regina de Beer; Alex F de Vos; Onno J de Boer; Tom van der Poll
Platelet-activating factor receptor contributes to host defense against Pseudomonas aeruginosa pneumonia but is not essential for the accompanying inflammatory and procoagulant response.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3357-65.
2008: W Joost Wiersinga; Alex F de Vos; Regina de Beer; Catharina W Wieland; Joris J T H Roelofs; Donald E Woods; Tom van der Poll
Inflammation patterns induced by different Burkholderia species in mice.
Cellular microbiology 2008;10(1):81-7.
2007: Ida A J Giebelen; David J van Westerloo; Greg La Rosa; Alex F de Vos; Tom van der Poll
Local stimulation of alpha7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lung.
Shock (Augusta, Ga.) 2007;28(6):700-3.
2007: Cornelis van 't Veer; Petra S van den Pangaart; Marieke A D van Zoelen; Martijn D de Kruif; Rakesh S Birjmohun; Eric S Stroes; Alex F de Vos; Tom van der Poll
Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):7110-20.
2007: Marieke A D van Zoelen; Alex F de Vos; Greg La Rosa; Christian Draing; Sonja Von Aulock; Tom van der Poll
Intrapulmonary delivery of ethyl pyruvate attenuates lipopolysaccharide- and lipoteichoic acid-induced lung inflammation in vivo.
Shock (Augusta, Ga.) 2007;28(5):570-5.
2007: W Joost Wiersinga; Catharina W Wieland; Mark C Dessing; Narisara Chantratita; Allen C Cheng; Direk Limmathurotsakul; Wirongrong Chierakul; Masja Leendertse; Sandrine Florquin; Alex F de Vos; Nicholas White; Arjen M Dondorp; Nicholas P J Day; Sharon J Peacock; Tom van der Poll
Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis).
PLoS medicine 2007;4(7):e248.
2007: Ida A J Giebelen; David J van Westerloo; Greg La Rosa; Alex F de Vos; Tom van der Poll
Stimulation of alpha 7 cholinergic receptors inhibits lipopolysaccharide-induced neutrophil recruitment by a tumor necrosis factor alpha-independent mechanism.
Shock (Augusta, Ga.) 2007;27(4):443-7.
2007: Mark C Dessing; Sylvia Knapp; Sandrine Florquin; Alex F de Vos; Tom van der Poll
CD14 facilitates invasive respiratory tract infection by Streptococcus pneumoniae.
American journal of respiratory and critical care medicine 2007;175(6):604-11.
2007: Martijn D de Kruif; Lucienne C Lemaire; Ida A J Giebelen; Marieke A D van Zoelen; Jennie M Pater; Petra S van den Pangaart; Angelique P Groot; Alex F de Vos; Peter J Elliott; Joost C M Meijers; Marcel Levi; Tom van der Poll
Prednisolone dose-dependently influences inflammation and coagulation during human endotoxemia.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1845-51.
2007: Nico A Maris; Alex F de Vos; Paul Bresser; jaring s. van der zee; Henk M Jansen; Marcel Levi; Tom van der Poll
Salmeterol enhances pulmonary fibrinolysis in healthy volunteers.
Critical care medicine 2007;35(1):57-63.
2006: Mark C Dessing; Alex F de Vos; Sandrine Florquin; Tom van der Poll
Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia.
Infection and immunity 2006;74(12):7021-3.
2006: Nico A Maris; Mark C Dessing; Alex F de Vos; Paul Bresser; jaring s. van der zee; Henk M Jansen; C Arnold Spek; Tom van der Poll
Toll-like receptor mRNA levels in alveolar macrophages after inhalation of endotoxin.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;28(3):622-6.
2006: David J van Westerloo; Ida A J Giebelen; Joost C M Meijers; Joost Daalhuisen; Alex F de Vos; Marcel Levi; Tom van der Poll
Vagus nerve stimulation inhibits activation of coagulation and fibrinolysis during endotoxemia in rats.
Journal of thrombosis and haemostasis : JTH 2006;4(9):1997-2002.
2006: Rosemarijn Renckens; Joris J T H Roelofs; Sandrine Florquin; Alex F de Vos; Jennie M Pater; H Roger Lijnen; Peter Carmeliet; Cornelis van 't Veer; Tom van der Poll
Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1189-96.
2006: Michiel E Stegenga; Saskia N van der Crabben; Marcel Levi; Alex F de Vos; Michael W T Tanck; Hans P Sauerwein; Tom van der Poll
Hyperglycemia stimulates coagulation, whereas hyperinsulinemia impairs fibrinolysis in healthy humans.
Diabetes 2006;55(6):1807-12.
2006: Rosemarijn Renckens; Joris J T H Roelofs; Sandrine Florquin; Alex F de Vos; H Roger Lijnen; Cornelis Van't Veer; Tom van der Poll
Matrix metalloproteinase-9 deficiency impairs host defense against abdominal sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3735-41.
2006: Rosemarijn Renckens; Joris J T H Roelofs; Sylvia Knapp; Alex F de Vos; Sandrine Florquin; Tom van der Poll
The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter baumannii Pneumonia.
The Journal of infectious diseases 2006;193(2):187-95.
2006: Nico A Maris; Sandrine Florquin; Cornelis Van't Veer; Alex F de Vos; Wim A Buurman; Henk M Jansen; Tom van der Poll
Inhalation of beta 2 agonists impairs the clearance of nontypable Haemophilus influenzae from the murine respiratory tract.
Respiratory research 2006;7():57.
2006: Michael Heesen; Rosemarijn Renckens; Alex F de Vos; Dagmar Kunz; Tom van der Poll
Human endotoxemia induces down-regulation of monocyte CC chemokine receptor 2.
Clinical and vaccine immunology : CVI 2006;13(1):156-9.
2005: Nico A Maris; Alex F de Vos; Mark C Dessing; C Arnold Spek; René Lutter; Henk M Jansen; jaring s. van der zee; Paul Bresser; Tom van der Poll
Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers.
American journal of respiratory and critical care medicine 2005;172(7):878-84.
2005: David J van Westerloo; Sylvia Knapp; Cornelis Van't Veer; Wim A Buurman; Alex F de Vos; Sandrine Florquin; Tom van der Poll
Aspiration pneumonitis primes the host for an exaggerated inflammatory response during pneumonia.
Critical care medicine 2005;33(8):1770-8.
2005: David J van Westerloo; Ida A J Giebelen; Sandrine Florquin; Joost Daalhuisen; Marco J Bruno; Alex F de Vos; Kevin Tracey; Tom van der Poll
The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis.
The Journal of infectious diseases 2005;191(12):2138-48.
2005: Nico A Maris; Alex F de Vos; Paul Bresser; jaring s. van der zee; Joost C M Meijers; H Roger Lijnen; Marcel Levi; Henk M Jansen; Tom van der Poll
Activation of coagulation and inhibition of fibrinolysis in the lung after inhalation of lipopolysaccharide by healthy volunteers.
Thrombosis and haemostasis 2005;93(6):1036-40.
2005: Anita W Rijneveld; Alex F de Vos; Sandrine Florquin; Sjef Verbeek; Tom van der Poll
CD11b limits bacterial outgrowth and dissemination during murine pneumococcal pneumonia.
The Journal of infectious diseases 2005;191(10):1755-60.
2005: David J van Westerloo; Sebastiaan Weijer; Marco J Bruno; Alex F de Vos; Cornelis Van't Veer; Tom van der Poll
Toll-like receptor 4 deficiency and acute pancreatitis act similarly in reducing host defense during murine Escherichia coli peritonitis.
Critical care medicine 2005;33(5):1036-43.
2005: David J van Westerloo; Sandrine Florquin; Anita M de Boer; Joost Daalhuisen; Alex F de Vos; Marco J Bruno; Tom van der Poll
Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice.
The American journal of pathology 2005;166(3):721-8.
2004: Catharina W Wieland; Sylvia Knapp; Sandrine Florquin; Alex F de Vos; Kiyoshi Takeda; Shizuo Akira; Douglas T Golenbock; Annelies Verbon; Tom van der Poll
Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2.
American journal of respiratory and critical care medicine 2004;170(12):1367-74.
2004: David J van Westerloo; Marcus Schultz; Marco J Bruno; Alex F de Vos; Sandrine Florquin; Tom van der Poll
Acute pancreatitis in mice impairs bacterial clearance from the lungs, whereas concurrent pneumonia prolongs the course of pancreatitis.
Critical care medicine 2004;32(10):1997-2001.
2004: Nico A Maris; Koenraad F van der Sluijs; Sandrine Florquin; Alex F de Vos; Jennie M Pater; Henk M Jansen; Tom van der Poll
Salmeterol, a beta2-receptor agonist, attenuates lipopolysaccharide-induced lung inflammation in mice.
American journal of physiology. Lung cellular and molecular physiology 2004;286(6):L1122-8.
2004: Rosemarijn Renckens; Sebastiaan Weijer; Alex F de Vos; Jennie M Pater; Joost C M Meijers; C Erik Hack; Marcel Levi; Tom van der Poll
Inhibition of plasmin activity by tranexamic acid does not influence inflammatory pathways during human endotoxemia.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(3):483-8.
2003: Sylvia Knapp; Alex F de Vos; Sandrine Florquin; Douglas T Golenbock; Tom van der Poll
Lipopolysaccharide binding protein is an essential component of the innate immune response to Escherichia coli peritonitis in mice.
Infection and immunity 2003;71(12):6747-53.
2003: Eric Eldering; C Arnold Spek; Hella L Aberson; Annette Grummels; Ingrid A M Derks; Alex F de Vos; Cathal J McElgunn; Jan P Schouten
Expression profiling via novel multiplex assay allows rapid assessment of gene regulation in defined signalling pathways.
Nucleic acids research 2003;31(23):e153.
2003: Sebastiaan Weijer; Miguel E Sewnath; Alex F de Vos; Sandrine Florquin; Koen van der Sluis; Dirk J Gouma; Kiyoshi Takeda; Shizuo Akira; Tom van der Poll
Interleukin-18 facilitates the early antimicrobial host response to Escherichia coli peritonitis.
Infection and immunity 2003;71(10):5488-97.