FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Jan de Wit

Research Profile

Physiology

Living Beings

Disorders

Phenomena

Ultraviolet Rays

Chemicals & Drugs

Anatomy

Procedures

Gene Targeting

Co-author Network

Publications

TOP 3
Arjan F Theil; Marcel Vermeij; Jan de Wit; Jeroen Essers; Giuseppina Giglia-Mari; Jan H J Hoeijmakers; Charlène Lemaitre; Alex Maas; Pierre-Olivier Mari; Jurgen A Marteijn; Julie Nonnekens; Anja Raams; Barbara Steurer; Wim Vermeulen
Disruption of TTDA Results in Complete Nucleotide Excision Repair Deficiency and Embryonic Lethality.
Giuseppina Giglia-Mari; Arjan F Theil; Pierre-Olivier Mari; Sophie Mourgues; Julie Nonnekens; Lise O Andrieux; Jan de Wit; Catherine Miquel; Nils Wijgers; Alex Maas; Maria Fousteri; Jan H J Hoeijmakers; Wim Vermeulen
Differentiation driven changes in the dynamic organization of Basal transcription initiation.
Jaan-Olle Andressoo; Geert Weeda; Jan de Wit; James R Mitchell; Rudolf B Beems; Harry van Steeg; Gijsbertus T J van der Horst; Jan H Hoeijmakers
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Jan de Wit (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Arjan F Theil; Marcel Vermeij; Jan de Wit; Jeroen Essers; Giuseppina Giglia-Mari; Jan H J Hoeijmakers; Charlène Lemaitre; Alex Maas; Pierre-Olivier Mari; Jurgen A Marteijn; Julie Nonnekens; Anja Raams; Barbara Steurer; Wim Vermeulen
Disruption of TTDA Results in Complete Nucleotide Excision Repair Deficiency and Embryonic Lethality.
PLoS genetics 2013;9(4):e1003431.
2009: Giuseppina Giglia-Mari; Arjan F Theil; Pierre-Olivier Mari; Sophie Mourgues; Julie Nonnekens; Lise O Andrieux; Jan de Wit; Catherine Miquel; Nils Wijgers; Alex Maas; Maria Fousteri; Jan H J Hoeijmakers; Wim Vermeulen
Differentiation driven changes in the dynamic organization of Basal transcription initiation.
PLoS biology 2009;7(10):e1000220.
2009: Jaan-Olle Andressoo; Geert Weeda; Jan de Wit; James R Mitchell; Rudolf B Beems; Harry van Steeg; Gijsbertus T J van der Horst; Jan H Hoeijmakers
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.
Molecular and cellular biology 2009;29(5):1276-90.
2008: Harm de Waard; Edwin Sonneveld; Jan de Wit; Rebecca Esveldt-van Lange; Jan H J Hoeijmakers; Harry Vrieling; Gijsbertus T J van der Horst
Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.
DNA repair 2008;7(10):1659-69.
2007: Ingrid van der Pluijm; george garinis; Renata M C Brandt; Theo G M F Gorgels; Susan W P Wijnhoven; Karin E M Diderich; Jan de Wit; James R Mitchell; Conny Th M van Oostrom; Rudolf B Beems; Laura J Niedernhofer; Susana Velasco; Errol C Friedberg; Kiyoji Tanaka; Harry van Steeg; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.
PLoS biology 2007;5(1):e2.
2006: Jaan-Olle Andressoo; Judith Jans; Jan de Wit; Frédéric Coin; Deborah Hoogstraten; Marieke van de Ven; Wendy Toussaint; Jan G M Huijmans; H Bing Thio; Wibeke J van Leeuwen; Jan de Boer; Jean-Marc Egly; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; James R Mitchell
Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles.
PLoS biology 2006;4(10):e322.
2006: Jaan-Olle Andressoo; James R Mitchell; Jan de Wit; Deborah Hoogstraten; Marcel Volker; Wendy Toussaint; Ewoud Speksnijder; Rudolf B Beems; Harry van Steeg; Judith Jans; Chris I De Zeeuw; Nicolaas G J Jaspers; Anja Raams; Alan Lehmann; Wim Vermeulen; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria.
Cancer cell 2006;10(2):121-32.
2004: Harm de Waard; Jan de Wit; Jaan-Olle Andressoo; Conny Th M van Oostrom; Bente Riis; Allan Weimann; Henrik E Poulsen; Harry van Steeg; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage.
Molecular and cellular biology 2004;24(18):7941-8.
2004: Laura J Niedernhofer; Hanny Odijk; Magda Budzowska; Ellen van Drunen; Alex Maas; Arjan F Theil; Jan de Wit; Nicolaas G J Jaspers; Berna Beverloo; Jan H J Hoeijmakers; Roland Kanaar
The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks.
Molecular and cellular biology 2004;24(13):5776-87.
2004: Henk P Roest; Willy M Baarends; Jan de Wit; Jan W van Klaveren; Evelyne Wassenaar; Jos W Hoogerbrugge; Wiggert A van Cappellen; Jan H J Hoeijmakers; J Anton Grootegoed
The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice.
Molecular and cellular biology 2004;24(12):5485-95.
2003: Harm de Waard; Jan de Wit; Theo G M F Gorgels; Gerard van den Aardweg; Jaan-Olle Andressoo; Marcel Vermeij; Harry van Steeg; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice.
DNA repair 2003;2(1):13-25.
2002: Wouter Schul; Judith Jans; Yvonne Rijksen; Kyra H M Klemann; Andre P M Eker; Jan de Wit; Osamu Nikaido; Satoshi Nakajima; Akira Yasui; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice.
The EMBO journal 2002;21(17):4719-29.
2002: Jan de Boer; Jaan-Olle Andressoo; Jan de Wit; Jan G M Huijmans; Rudolf B Beems; Harry van Steeg; Geert Weeda; Gijsbertus T J van der Horst; Wibeke J van Leeuwen; Axel P N Themmen; Morteza Meradji; Jan H J Hoeijmakers
Premature aging in mice deficient in DNA repair and transcription.
Science (New York, N.Y.) 2002;296(5571):1276-9.
2002: Gijsbertus T J van der Horst; Lisiane Meira; Theo G M F Gorgels; Jan de Wit; Susana Velasco-Miguel; James A Richardson; Yvonne Kamp; Maaike P G Vreeswijk; Bep Smit; Dirk Bootsma; Jan H J Hoeijmakers; Errol C Friedberg
UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice.
DNA repair 2002;1(2):143-57.
2001: Laura J Niedernhofer; Jeroen Essers; Geert Weeda; Berna Beverloo; Jan de Wit; Manja Muijtjens; Hanny Odijk; Jan H J Hoeijmakers; Roland Kanaar
The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells.
The EMBO journal 2001;20(22):6540-9.
2000: Mies L G Dronkert; Jan de Wit; M Boeve; M L Vasconcelos; Harry van Steeg; T L Raoul Tan; Jan H J Hoeijmakers; Roland Kanaar
Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C.
Molecular and cellular biology 2000;20(13):4553-61.
2000: Jeroen Essers; Harry van Steeg; Jan de Wit; SM Swagemakers; Marcel Vermeij; Jan H J Hoeijmakers; Roland Kanaar
Homologous and non-homologous recombination differentially affect DNA damage repair in mice.
The EMBO journal 2000;19(7):1703-10.
1999: Jan de Boer; Harry van Steeg; Rob J W Berg; Johan Garssen; Jan de Wit; C T van Oostrum; Rudolf B Beems; Gijsbertus T J van der Horst; Coen F van Kreijl; Frank R de Gruijl; Dirk Bootsma; Jan H J Hoeijmakers; Geert Weeda
Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition.
Cancer research 1999;59(14):3489-94.
1999: Gijsbertus T J van der Horst; Manja Muijtjens; Kumiko Kobayashi; R Takano; Shin-ichiro Kanno; Masashi Takao; Jan de Wit; A Verkerk; Andre P M Eker; Dik van Leenen; R Buijs; Dirk Bootsma; Jan H J Hoeijmakers; Akira Yasui
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms.
Nature 1999;398(6728):627-30.
1999: T L Raoul Tan; Jeroen Essers; Elisabetta Citterio; SM Swagemakers; Jan de Wit; F E Benson; Jan H J Hoeijmakers; Roland Kanaar
Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation.
Current biology : CB 1999;9(6):325-8.
1998: SM Swagemakers; Jeroen Essers; Jan de Wit; Jan H J Hoeijmakers; Roland Kanaar
The human RAD54 recombinational DNA repair protein is a double-stranded DNA-dependent ATPase.
The Journal of biological chemistry 1998;273(43):28292-7.
1998: Jan de Boer; Jan de Wit; Harry van Steeg; Rob J W Berg; Hans Morreau; P Visser; Alan Lehmann; M Duran; Jan H J Hoeijmakers; Geert Weeda
A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy.
Molecular cell 1998;1(7):981-90.
1998: Geert Weeda; Jan de Boer; I Donker; Jan de Wit; S B Winkler; Gijsbertus T J van der Horst; Wim Vermeulen; Dirk Bootsma; Jan H J Hoeijmakers
Molecular basis of DNA repair mechanisms and syndromes.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1998;154():147-55.
1998: Jan de Boer; I Donker; Jan de Wit; Jan H J Hoeijmakers; Geert Weeda
Disruption of the mouse xeroderma pigmentosum group D DNA repair/basal transcription gene results in preimplantation lethality.
Cancer research 1998;58(1):89-94.
1997: Bevin P Engelward; Geert Weeda; Michael D Wyatt; J L Broekhof; Jan de Wit; I Donker; JM Allan; B Gold; Jan H J Hoeijmakers; Leona D Samson
Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13087-92.
1997: Geert Weeda; I Donker; Jan de Wit; Hans Morreau; R Janssens; C J Vissers; Alex L Nigg; Harry van Steeg; Dirk Bootsma; Jan H J Hoeijmakers
Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence.
Current biology : CB 1997;7(6):427-39.
1997: Gijsbertus T J van der Horst; Harry van Steeg; Rob J W Berg; Alain van Gool; Jan de Wit; Geert Weeda; Hans Morreau; Rudolf B Beems; Coen F van Kreijl; Frank R de Gruijl; Dirk Bootsma; Jan H J Hoeijmakers
Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition.
Cell 1997;89(3):425-35.
1997: Jeroen Essers; Rudolf W Hendriks; SM Swagemakers; C Troelstra; Jan de Wit; Dirk Bootsma; Jan H J Hoeijmakers; Roland Kanaar
Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.
Cell 1997;89(2):195-204.
1997: David B Busch; H van Vuuren; Jan de Wit; A Collins; Malgorzata Z Zdzienicka; D L Mitchell; KW Brookman; M Stefanini; R Riboni; Larry H Thompson; Roberta B Albert; Alain van Gool; Jan H J Hoeijmakers
Phenotypic heterogeneity in nucleotide excision repair mutants of rodent complementation groups 1 and 4.
Mutation research 1997;383(2):91-106.
1996: Henk P Roest; J van Klaveren; Jan de Wit; C G van Gurp; Marcel Koken; M Vermey; J H van Roijen; Jos W Hoogerbrugge; Jan Vreeburg; Willy M Baarends; Dirk Bootsma; J Anton Grootegoed; Jan H J Hoeijmakers
Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.
Cell 1996;86(5):799-810.
1996: Marcel Koken; Jos W Hoogerbrugge; I Jasper-Dekker; Jan de Wit; R Willemsen; Henk P Roest; J Anton Grootegoed; Jan H J Hoeijmakers
Expression of the ubiquitin-conjugating DNA repair enzymes HHR6A and B suggests a role in spermatogenesis and chromatin modification.
Developmental biology 1996;173(1):119-32.
1994: D Busch; C Greiner; K L Rosenfeld; R Ford; Jan de Wit; Jan H J Hoeijmakers; Larry H Thompson
Complementation group assignments of moderately UV-sensitive CHO mutants isolated by large-scale screening (FAECB).
Mutagenesis 1994;9(4):301-6.
1992: C Troelstra; Alain van Gool; Jan de Wit; Wim Vermeulen; Dirk Bootsma; Jan H J Hoeijmakers
ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes.
Cell 1992;71(6):939-53.
1990: C Troelstra; H Odijk; Jan de Wit; A Westerveld; L H Thompson; Dirk Bootsma; Jan H J Hoeijmakers
Molecular cloning of the human DNA excision repair gene ERCC-6.
Molecular and cellular biology 1990;10(11):5806-13.
1990: Geert Weeda; R C van Ham; R Masurel; A Westerveld; H Odijk; Jan de Wit; Dirk Bootsma; Alex J van der Eb; Jan H J Hoeijmakers
Molecular cloning and biological characterization of the human excision repair gene ERCC-3.
Molecular and cellular biology 1990;10(6):2570-81.
1988: M van Duin; J H Janssen; Jan de Wit; Jan H J Hoeijmakers; L H Thompson; Dirk Bootsma; A Westerveld
Transfection of the cloned human excision repair gene ERCC-1 to UV-sensitive CHO mutants only corrects the repair defect in complementation group-2 mutants.
Mutation research 1988;193(2):123-30.
1986: M van Duin; Jan de Wit; H Odijk; A Westerveld; A Yasui; Marcel Koken; Jan H J Hoeijmakers; Dirk Bootsma
Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10.
Cell 1986;44(6):913-23.
1984: A Westerveld; Jan H J Hoeijmakers; M van Duin; Jan de Wit; H Odijk; A Pastink; R D Wood; Dirk Bootsma
Molecular cloning of a human DNA repair gene.
Nature 1984;310(5976):425-9.