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Silvia Deaglio

Research Profile

Chemicals & Drugs

Disorders

B-Cell Chronic Lymphocytic Leukemia

Physiology

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Tiziana Vaisitti; Gianluca Gaidano; Luca Laurenti; Fabio Malavasi; C Pepper; Davide Rossi; S Serra; Silvia Deaglio
CD38 signals upregulate expression and functions of matrix metalloproteinase-9 in chronic lymphocytic leukemia cells.
Maria Serena Longhi; Simon C Robson; Sara Serra; Steven H Bernstein; Silvia Deaglio
Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states.
Valentina Audrito; Cinzia Bologna; Davide Brusa; Fabio Malavasi; Sara Serra; Tiziana Vaisitti; Silvia Deaglio
Targeting the microenvironment in chronic lymphocytic leukemia offers novel therapeutic options.

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All Publications

2013: Tiziana Vaisitti; Gianluca Gaidano; Luca Laurenti; Fabio Malavasi; C Pepper; Davide Rossi; S Serra; Silvia Deaglio
CD38 signals upregulate expression and functions of matrix metalloproteinase-9 in chronic lymphocytic leukemia cells.
Leukemia 2013;27(5):1177-81.
2013: Maria Serena Longhi; Simon C Robson; Sara Serra; Steven H Bernstein; Silvia Deaglio
Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states.
Journal of molecular medicine (Berlin, Germany) 2013;91(2):165-72.
2013: Valentina Audrito; Cinzia Bologna; Davide Brusa; Fabio Malavasi; Sara Serra; Tiziana Vaisitti; Silvia Deaglio
Targeting the microenvironment in chronic lymphocytic leukemia offers novel therapeutic options.
Cancer letters 2013;328(1):27-35.
2012: Giovanni D'Arena; Fiorella D'Auria; Silvia Deaglio; Luigi Del Vecchio; Marica Gemei; Vitina Grieco; Roberto Guariglia; Luigiana Luciano; Giovanna Mansueto; Maria Carmen Martorelli; Giuseppe Pietrantuono; Teodora Statuto; Oreste Villani; Gabriella Bianchino; Pellegrino Musto
Chronic lymphocytic leukemia after chronic myeloid leukemia in the same patient: two different genomic events and a common treatment?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(32):e327-30.
2012: Giovanni D'Arena; Fiorella D'Auria; Vincenzo De Feo; Silvia Deaglio; Roberto Guariglia; Idanna Innocenti; Luca Laurenti; Giovanna Mansueto; Maria Carmen Martorelli; Giuseppe Pietrantuono; Vittorio Simeon; Teodora Statuto; Oreste Villani; Giovanni Del Poeta; Maria Ilaria Del Principe; Pellegrino Musto
A shorter time to the first treatment may be predicted by the absolute number of regulatory T-cells in patients with Rai stage 0 chronic lymphocytic leukemia.
American journal of hematology 2012;87(6):628-31.
2012: Antonella Zucchetto; A Gorgone; F Malavasi; G Pozzato; Davide Rossi; E Tissino; Tiziana Vaisitti; Dania Benedetti; V Bertagnolo; Riccardo Bomben; Michele Dal Bo; Silvia Deaglio; Giovanni Del Poeta; Maria Ilaria Del Principe; Gianluca Gaidano; Valter Gattei
The CD49d/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells.
Leukemia 2012;26(6):1301-12.
2012: Rossana Maffei; Silvia Martinelli; Franco Narni; Giuseppe Torelli; Patrizia Zucchini; Goretta Bonacorsi; Jenny Bulgarelli; Ilaria Castelli; Valeria Coluccio; Silvia Deaglio; Giulia Debbia; Stefania Fiorcari; Marcella Fontana; Mario Luppi; Marasca Roberto
Physical contact with endothelial cells through β1- and β2- integrins rescues chronic lymphocytic leukemia cells from spontaneous and drug-induced apoptosis and induces a peculiar gene expression profile in leukemic cells.
Haematologica 2012;97(6):952-60.
2012: Davide Rossi; Valeria Spina; Tiziana Vaisitti; Valter Gattei; Mariangela Greco; Anna Guarini; Marilisa Marinelli; Sara Monti; Laura Pasqualucci; Silvia Rasi; Francesco Bertoni; Alessio Bruscaggin; Sabina Chiaretti; Stefania Cresta; Riccardo Dalla-Favera; Giulia Daniele; Silvia Deaglio; Clara Deambrogi; Ilaria Del Giudice; Giulia Fabbri; Rosella Famà; Marco Fangazio; Robin Foà; Francesco Forconi; Gianluca Gaidano
Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia.
Blood 2012;119(12):2854-62.
2012: Davide Rossi; Valeria Spina; Alessio Bruscaggin; Pietro Bulian; Daniela Capello; Michaela Cerri; Stefania Cresta; Riccardo Dalla-Favera; Lorenzo De Paoli; Silvia Deaglio; Giulia Fabbri; Rosella Famà; Marco Fangazio; Robin Foà; Francesco Forconi; Valter Gattei; Anna Guarini; Luca Laurenti; Marasca Roberto; Sara Monti; Laura Pasqualucci; Raul Rabadan; Silvia Rasi; Gianluca Gaidano
Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia.
Blood 2012;119(2):521-9.
2012: Gianluca Isoardo; Carola Junemann; Andrea Limberti; Fabio Malavasi; Antonio Melcarne; Isabella Morra; Michele Naddeo; Maria Consuelo Valentini; Valentina Audrito; Giulia Chiarle; Maurizio Cogoni; Silvia Deaglio; Federico Faccani; G Faccani
Different aquaporin-4 expression in glioblastoma multiforme patients with and without seizures.
Molecular medicine (Cambridge, Mass.) 2012;18():1147-51.
2012: Michele Dal Bo; Silvia Deaglio; Giovanni Del Poeta; Dimitar G Efremov; Gianluca Gaidano; Riccardo Bomben; Antonella Zucchetto; Valter Gattei
Microenvironmental interactions in chronic lymphocytic leukemia: hints for pathogenesis and identification of targets for rational therapy.
Current pharmaceutical design 2012;18(23):3323-34.
2011: Sara Serra; Claudio Tripodo; Tiziana Vaisitti; Davide Brusa; Marta Coscia; Giovanni D'Arena; Gianluca Gaidano; Alberto L Horenstein; Giorgio Inghirami; Luca Laurenti; Fabio Malavasi; Simon C Robson; Davide Rossi; Silvia Deaglio
CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death.
Blood 2011;118(23):6141-52.
2011: Davide Rossi; Valeria Spina; Catherine Thieblemont; Tiziana Vaisitti; Ivo Kwee; Marco Lucioni; Marasca Roberto; Sara Monti; Laura Pasqualucci; Stefano A Pileri; Silvia Rasi; Claudio Agostinelli; Luca Arcaini; Francesco Bertoni; Alessio Bruscaggin; Daniela Capello; Michaela Cerri; Stefania Cresta; Riccardo Dalla-Favera; Silvia Deaglio; David Dominguez-Sola; Fabio Facchetti; Marco Fangazio; Robin Foà; Gianluca Gaidano
Alteration of BIRC3 and multiple other NF-κB pathway genes in splenic marginal zone lymphoma.
Blood 2011;118(18):4930-4.
2011: Annalisa Pezzolo; Angela Pistorio; Lizzia Raffaghello; Michele Cilli; Claudia Cocco; Silvia Deaglio; Claudio Gambini; Fabio Malavasi; Danilo Marimpietri; Manuela Mosconi; Federica Parodi; Vito Pistoia
Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells.
Cell research 2011;21(10):1470-86.
2011: Fabio Malavasi; Giovanna Cutrona; Rajendra N Damle; Silvia Deaglio; Manlio Ferrarini; Nicholas Chiorazzi
CD38 and chronic lymphocytic leukemia: a decade later.
Blood 2011;118(13):3470-8.
2011: Valentina Audrito; Giovanni D'Arena; Gianluca Gaidano; Daniela Gottardi; Luca Laurenti; Fabio Malavasi; Davide Rossi; Tiziana Vaisitti; Silvia Deaglio
Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network.
Cancer research 2011;71(13):4473-83.
2011: Dalemari Crowther-Swanepoel; Giovanni D'Arena; Silvia Deaglio; Maria Chiara Di Bernardo; Irena Frydecka; Gianluca Gaidano; Peter Broderick; Daniel Catovsky; Krzysztof Jamroziak; Lidia Karabon; Luca Laurenti; Amy Lloyd; Bianca Olver; Tadeusz Robak; Davide Rossi; Zofia Szemraj-Rogucka; Richard S Houlston
Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk.
British journal of haematology 2011;154(2):229-33.
2011: Silvia Sandini; Antonio Cassone; Silvia Deaglio; Roberto La Valle; Fabio Malavasi; Flavia De Bernardis
A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rSap2t) of Candida albicans as a mucosal anticandidal vaccine.
FEMS immunology and medical microbiology 2011;62(2):215-24.
2011: Tiziana Vaisitti; Valentina Audrito; Sara Serra; Cinzia Bologna; Davide Brusa; Fabio Malavasi; Silvia Deaglio
NAD+-metabolizing ecto-enzymes shape tumor-host interactions: the chronic lymphocytic leukemia model.
FEBS letters 2011;585(11):1514-20.
2011: Giovanni D'Arena; V De Feo; L De Martino; Silvia Deaglio; B M Fusco; L Laurenti; A M Carella; N Cascavilla; P Musto
Targeting regulatory T cells for anticancer therapy.
Mini reviews in medicinal chemistry 2011;11(6):480-5.
2011: Silvia Deaglio; D Gottardi; L Laurenti; V Audrito; C Bologna; Giovanni D'Arena; S Serra; Tiziana Vaisitti; F Malavasi
CD38 in chronic lymphocytic leukemia: from bench to bedside?
Mini reviews in medicinal chemistry 2011;11(6):503-7.
2011: L Laurenti; S Sica; Michela Tarnani; B Vannata; Giovanni D'Arena; L De Padua; Silvia Deaglio; Dimitar G Efremov; I Innocenti; G Leone
New and old monoclonal antibodies for the treatment of chronic lymphocytic leukemia.
Mini reviews in medicinal chemistry 2011;11(6):508-18.
2011: Pietro Bulian; Giovanni D'Arena; Silvia Deaglio; Giovanni Del Poeta; Dimitar G Efremov; Francesco Forconi; Gianluca Gaidano; Valter Gattei; Francesco Lauria; Marasca Roberto; Marco Montillo; Gabriele Pozzato; Davide Rossi; Michela Tarnani; Emanuele Zucca; Francesco Bertoni; Luca Laurenti
Multicentre validation of a prognostic index for overall survival in chronic lymphocytic leukaemia.
Hematological oncology 2011;29(2):91-9.
2011: Beat M Künzli; Pascal O Berberat; Karen Dwyer; Silvia Deaglio; Eva Csizmadia; Peter Cowan; Anthony d'Apice; Gregory Moore; Keiichi Enjyoji; Helmut Friess; Simon C Robson
Variable impact of CD39 in experimental murine colitis.
Digestive diseases and sciences 2011;56(5):1393-403.
2011: I Saborit-Villarroya; Tiziana Vaisitti; Davide Rossi; G D'Arena; Gianluca Gaidano; Fabio Malavasi; Silvia Deaglio
E2A is a transcriptional regulator of CD38 expression in chronic lymphocytic leukemia.
Leukemia 2011;25(3):479-88.
2011: Giovanni D'Arena; Luca Laurenti; Maria Marta Minervini; Silvia Deaglio; Lisa Bonello; Laura De Martino; Laura De Padua; Lucia Savino; Michela Tarnani; Vincenzo De Feo; Nicola Cascavilla
Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease.
Leukemia research 2011;35(3):363-8.
2011: Silvia Rasi; Valeria Spina; Alessio Bruscaggin; Tiziana Vaisitti; Claudio Tripodo; Francesco Forconi; Lorenzo De Paoli; Marco Fangazio; Elisa Sozzi; Emanuele Cencini; Luca Laurenti; Marasca Roberto; Carlo Visco; Zijun Y Xu-Monette; Valter Gattei; Ken H Young; Fabio Malavasi; Silvia Deaglio; Gianluca Gaidano; Davide Rossi
A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome.
British journal of haematology 2011;152(3):284-94.
2011: Silvia Deaglio; Simon C Robson
Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity.
Advances in pharmacology (San Diego, Calif.) 2011;61():301-32.
2010: Giovanni D'Arena; Silvana Capalbo; Luca Laurenti; Giovanni Del Poeta; Giuseppe Nunziata; Silvia Deaglio; Giuseppina Spinosa; Michela Tarnani; Laura De Padua; Catello Califano; Felicetto Ferrara; Nicola Cascavilla
Chronic lymphocytic leukemia-associated immune thrombocytopenia treated with rituximab: a retrospective study of 21 patients.
European journal of haematology 2010;85(6):502-7.
2010: Silvia Deaglio; Tiziana Vaisitti; Antonella Zucchetto; Valter Gattei; Fabio Malavasi
CD38 as a molecular compass guiding topographical decisions of chronic lymphocytic leukemia cells.
Seminars in cancer biology 2010;20(6):416-23.
2010: Fabio Malavasi; Silvia Deaglio; Gianluca Zaccarello; Alberto L Horenstein; Antonella Chillemi; Valentina Audrito; Sara Serra; Marina Gandione; Andrea Zitella; Alessandro Tizzani
The hidden life of NAD+-consuming ectoenzymes in the endocrine system.
Journal of molecular endocrinology 2010;45(4):183-91.
2010: Antonella Zucchetto; Claudio Tripodo; Dania Benedetti; Silvia Deaglio; Gianluca Gaidano; Giovanni Del Poeta; Valter Gattei
Monocytes/macrophages but not T lymphocytes are the major targets of the CCL3/CCL4 chemokines produced by CD38(+)CD49d(+) chronic lymphocytic leukaemia cells.
British journal of haematology 2010;150(1):111-3.
2010: Tiziana Vaisitti; Semra Aydin; Davide Rossi; F Cottino; Luciana Bergui; Giovanni D'Arena; Lisa Bonello; Alberto L Horenstein; Paul Brennan; C Pepper; Gianluca Gaidano; Fabio Malavasi; Silvia Deaglio
CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells.
Leukemia 2010;24(5):958-69.
2010: Alessia Calzolari; Luigi Maria Larocca; Silvia Deaglio; Veronica Finisguerra; Alessandra Boe; Carla Raggi; Lucia Ricci-Vitani; Francesco Pierconti; Fabio Malavasi; Ruggero De Maria; Ugo Testa; Roberto Pallini
Transferrin receptor 2 is frequently and highly expressed in glioblastomas.
Translational oncology 2010;3(2):123-34.
2010: Laurence Pearce; Liam Morgan; Thet Thet Lin; Saman Hewamana; R James Matthews; Silvia Deaglio; Clare Rowntree; Christopher Fegan; Christopher Pepper; Paul Brennan
Genetic modification of primary chronic lymphocytic leukemia cells with a lentivirus expressing CD38.
Haematologica 2010;95(3):514-7.
2010: Silvia Deaglio; Semra Aydin; Maurizia Mello Grand; Tiziana Vaisitti; Luciana Bergui; Giovanni D'Arena; giovanna chiorino; Fabio Malavasi
CD38/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells.
Molecular medicine (Cambridge, Mass.) 2010;16(3-4):87-91.
2009: Alessia Calzolari; Silvia Deaglio; Elena Maldi; Paola Cassoni; Fabio Malavasi; Ugo Testa
TfR2 expression in human colon carcinomas.
Blood cells, molecules & diseases 2009;43(3):243-9.
2009: Davide Rossi; Valeria Spina; Michaela Cerri; Silvia Rasi; Clara Deambrogi; Lorenzo De Paoli; Luca Laurenti; Rossana Maffei; Francesco Forconi; Francesco Bertoni; Emanuele Zucca; Claudio Agostinelli; Antonello Cabras; Marco Lucioni; Maurizio Martini; Michele Magni; Silvia Deaglio; marco ladetto; Josep F Nomdedeu; Caroline Besson; Antonio Ramponi; Vincenzo Canzonieri; Marco Paulli; Marasca Roberto; Luigi M Larocca; Antonino Carbone; Stefano A Pileri; Valter Gattei; Gianluca Gaidano
Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(13):4415-22.
2009: Silvia Deaglio; Fabio Malavasi
Chronic lymphocytic leukemia microenvironment: shifting the balance from apoptosis to proliferation.
Haematologica 2009;94(6):752-6.
2009: Antonella Zucchetto; Dania Benedetti; Claudio Tripodo; Riccardo Bomben; Michele Dal Bo; Daniela Marconi; Fleur Bossi; Debora Lorenzon; Massimo Degan; Francesca Maria Rossi; Davide Rossi; Pietro Bulian; Vito Franco; Giovanni Del Poeta; Silvia Deaglio; Gianluca Gaidano; Francesco Tedesco; Fabio Malavasi; Valter Gattei
CD38/CD31, the CCL3 and CCL4 chemokines, and CD49d/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival.
Cancer research 2009;69(9):4001-9.
2009: Alberto L Horenstein; Federico Sizzano; Riccardo Lusso; Federico Genzano Besso; Enza Ferrero; Silvia Deaglio; F Corno; Fabio Malavasi
CD38 and CD157 ectoenzymes mark cell subsets in the human corneal limbus.
Molecular medicine (Cambridge, Mass.) 2009;15(3-4):76-84.
2009: Michele Dal Bo; Francesco Bertoni; Francesco Forconi; Antonella Zucchetto; Riccardo Bomben; Marasca Roberto; Silvia Deaglio; Luca Laurenti; Dimitar G Efremov; Gianluca Gaidano; Giovanni Del Poeta; Valter Gattei
Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance.
Journal of translational medicine 2009;7():76.
2009: Alessia Calzolari; Veronica Finisguerra; Isabella Oliviero; Silvia Deaglio; Gualtiero Mariani; Fabio Malavasi; Ugo Testa
Regulation of transferrin receptor 2 in human cancer cell lines.
Blood cells, molecules & diseases 2009;42(1):5-13.
2008: Fabio Malavasi; Silvia Deaglio; Ada Funaro; Enza Ferrero; Alberto L Horenstein; Erika Ortolan; Tiziana Vaisitti; Semra Aydin
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology.
Physiological reviews 2008;88(3):841-86.
2008: Semra Aydin; Davide Rossi; Luciana Bergui; Giovanni D'Arena; Enza Ferrero; Lisa Bonello; Paola Omedé; Domenico Novero; Fortunato Morabito; Antonino Carbone; Gianluca Gaidano; Fabio Malavasi; Silvia Deaglio
CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome?
Blood 2008;111(12):5646-53.
2008: Silvia Deaglio; Semra Aydin; Tiziana Vaisitti; Luciana Bergui; Fabio Malavasi
CD38 at the junction between prognostic marker and therapeutic target.
Trends in molecular medicine 2008;14(5):210-8.
2007: Silvia Deaglio; Tiziana Vaisitti; Semra Aydin; Luciana Bergui; Giovanni D'Arena; Lisa Bonello; Paola Omedé; Maria Scatolini; Ozren Jaksic; giovanna chiorino; Dimitar Efremov; Fabio Malavasi
CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential.
Blood 2007;110(12):4012-21.
2007: Shaun Willimott; Maria Baou; Sarah Huf; Silvia Deaglio; Simon D Wagner
Regulation of CD38 in proliferating chronic lymphocytic leukemia cells stimulated with CD154 and interleukin-4.
Haematologica 2007;92(10):1359-66.
2007: Giovanni D'Arena; Michela Tarnani; Carlo Rumi; Tiziana Vaisitti; Semra Aydin; Rosaria De Filippi; Francesco Perrone; Antonio Pinto; Patrizia Chiusolo; Silvia Deaglio; Fabio Malavasi; Luca Laurenti
Prognostic significance of combined analysis of ZAP-70 and CD38 in chronic lymphocytic leukemia.
American journal of hematology 2007;82(9):787-91.
2007: Alessia Calzolari; Isabella Oliviero; Silvia Deaglio; Gualtiero Mariani; Mauro Biffoni; Nadia Maria Sposi; Fabio Malavasi; Cesare Peschle; Ugo Testa
Transferrin receptor 2 is frequently expressed in human cancer cell lines.
Blood cells, molecules & diseases 2007;39(1):82-91.
2007: Silvia Deaglio; Tiziana Vaisitti; Richard Billington; Luciana Bergui; Paola Omede'; Armando Genazzani; Fabio Malavasi
CD38/CD19: a lipid raft-dependent signaling complex in human B cells.
Blood 2007;109(12):5390-8.
2007: Silvia Deaglio; Karen M Dwyer; Keiichii Enjyoji; Anna Erat; David Friedman; Wenda Gao; Vijay K Kuchroo; Joel Linden; Mohamed Oukka; Terry B Strom; Anny Usheva; Jiang-Fan Chen; Simon C Robson
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.
The Journal of experimental medicine 2007;204(6):1257-65.
2007: Karen M Dwyer; Silvia Deaglio; Wenda Gao; David Friedman; Terry B Strom; Simon C Robson
CD39 and control of cellular immune responses.
Purinergic signalling 2007;3(1-2):171-80.
2006: Fortunato Morabito; Rajendra N Damle; Silvia Deaglio; Michael Keating; Manlio Ferrarini; Nicholas Chiorazzi
The CD38 ectoenzyme family: advances in basic science and clinical practice.
Molecular medicine (Cambridge, Mass.) 2006;12(11-12):342-4.
2006: Fabio Malavasi; Silvia Deaglio; Enza Ferrero; Ada Funaro; Jaime Sancho; Clara Maria Ausiello; Erika Ortolan; Tiziana Vaisitti; Mercedes Zubiaur; Giorgio Fedele; Semra Aydin; Elena V Tibaldi; Ilaria Durelli; Riccardo Lusso; Franco Cozno; Alberto L Horenstein
CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunity.
Molecular medicine (Cambridge, Mass.) 2006;12(11-12):334-41.
2006: Alessia Calzolari; Carla Raggi; Silvia Deaglio; Nadia Maria Sposi; Marit Stafsnes; Katia Fecchi; Isabella Parolini; Fabio Malavasi; Cesare Peschle; Massimo Sargiacomo; Ugo Testa
TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway.
Journal of cell science 2006;119(Pt 21):4486-98.
2006: Silvia Deaglio; Tiziana Vaisitti; Semra Aydin; Enza Ferrero; Fabio Malavasi
In-tandem insight from basic science combined with clinical research: CD38 as both marker and key component of the pathogenetic network underlying chronic lymphocytic leukemia.
Blood 2006;108(4):1135-44.
2006: Silvia Deaglio; Fabio Malavasi
The CD38/CD157 mammalian gene family: An evolutionary paradigm for other leukocyte surface enzymes.
Purinergic signalling 2006;2(2):431-41.
2006: Loredana Frasca; Giorgio Fedele; Silvia Deaglio; Cristina Capuano; Raffaella Palazzo; Tiziana Vaisitti; Fabio Malavasi; Clara Maria Ausiello
CD38 orchestrates migration, survival, and Th1 immune response of human mature dendritic cells.
Blood 2006;107(6):2392-9.
2005: Tiziana Vaisitti; Silvia Deaglio; Fabio Malavasi
Cationization of monoclonal antibodies: another step towards the "magic bullet"?
Journal of biological regulators and homeostatic agents 2005;19(3-4):105-12.
2005: Silvia Deaglio; Tiziana Vaisitti; Luciana Bergui; Lisa Bonello; Alberto L Horenstein; Luca Tamagnone; Laurence Boumsell; Fabio Malavasi
CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival.
Blood 2005;105(8):3042-50.
2005: Gianluca Isoardo; Silvia Deaglio; Dario Cocito; Giuseppe Migliaretti; Enza Ferrero; Federica Cavallo; Luca Durelli; Fabio Malavasi
Immunodetection of anti-MAG IgM antibody by cross-reactivity to LA-N-1 neuroblastoma cells.
Journal of neuroimmunology 2005;161(1-2):78-86.
2004: Alessia Calzolari; Silvia Deaglio; Nadia Maria Sposi; Eleonora Petrucci; Ornella Morsilli; Marco Gabbianelli; Fabio Malavasi; Cesare Peschle; Ugo Testa
Transferrin receptor 2 protein is not expressed in normal erythroid cells.
The Biochemical journal 2004;381(Pt 3):629-34.
2003: Silvia Deaglio; Andrea Capobianco; Luciana Bergui; Jan Dürig; Fortunato Morabito; Ulrich Dührsen; Fabio Malavasi
CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells.
Blood 2003;102(6):2146-55.
2003: Claudya Tenca; Andrea Merlo; Daniela Zarcone; Daniele Saverino; Silvia Bruno; Amleto De Santanna; Dunia Ramarli; Marina Fabbi; Carlo Pesce; Silvia Deaglio; Ermanno Ciccone; Fabio Malavasi; Carlo E Grossi
Death of T cell precursors in the human thymus: a role for CD38.
International immunology 2003;15(9):1105-16.
2003: Luisella Righi; Silvia Deaglio; Carla Pecchioni; Armando Gregorini; Alberto L Horenstein; Gianni Bussolati; Anna Sapino; Fabio Malavasi
Role of CD31/platelet endothelial cell adhesion molecule-1 expression in in vitro and in vivo growth and differentiation of human breast cancer cells.
The American journal of pathology 2003;162(4):1163-74.
2003: Jan Dürig; Holger Nückel; Andreas Hüttmann; Elisabeth Kruse; Tanja Hölter; Katja Halfmeyer; Anja Führer; Roland Rudolph; Naser Kalhori; Arnd Nusch; Silvia Deaglio; Fabio Malavasi; Tarik Möröy; Ludger Klein-Hitpass; Ulrich Dührsen
Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia.
Blood 2003;101(7):2748-55.
2003: Fortunato Morabito; Massimo Mangiola; Caterina Stelitano; Silvia Deaglio; Vincenzo Callea; Fabio Malavasi
Simultaneous expression of CD38 and its ligand CD31 by chronic lymphocytic leukemia B-cells: anecdotal observation or pathogenetic hypothesis for the clinical outcome?
Haematologica 2003;88(3):354-5.
2003: Andrea Savarino; Thea Bensi; Annalisa Chiocchetti; Flavia Bottarel; Riccardo Mesturini; Enza Ferrero; Liliana Calosso; Silvia Deaglio; Erika Ortolan; Stefano Buttò; Aurelio Aurelio Cafaro; Toshiaki Katada; Barbara Ensoli; Fabio Malavasi; Umberto Dianzani
Human CD38 interferes with HIV-1 fusion through a sequence homologous to the V3 loop of the viral envelope glycoprotein gp120.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(3):461-3.
2002: Silvia Deaglio; Andrea Capobianco; Angelita Calì; Francesca Bellora; Federica Alberti; Luisella Righi; Anna Sapino; Clara Camaschella; Fabio Malavasi
Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum.
Blood 2002;100(10):3782-9.
2002: Roberto Lande; Francesca Urbani; Beatrice Di Carlo; Giuseppe Sconocchia; Silvia Deaglio; Ada Funaro; Fabio Malavasi; Clara Maria Ausiello
CD38 ligation plays a direct role in the induction of IL-1beta, IL-6, and IL-10 secretion in resting human monocytes.
Cellular immunology 2002;220(1):30-8.
2002: Germano Baj; Alberto Arnulfo; Silvia Deaglio; Roberto Mallone; Alessandro Vigone; Maria Grazia De Cesaris; Nicola Surico; Fabio Malavasi; Enza Ferrero
Arsenic trioxide and breast cancer: analysis of the apoptotic, differentiative and immunomodulatory effects.
Breast cancer research and treatment 2002;73(1):61-73.
2002: Paola Cassoni; Anna Sapino; Silvia Deaglio; Benedetta Bussolati; Marco Volante; Luca Munaron; Adriana Albini; Antonietta Torrisi; Gianni Bussolati
Oxytocin is a growth factor for Kaposi's sarcoma cells: evidence of endocrine-immunological cross-talk.
Cancer research 2002;62(8):2406-13.
2002: Armando Gregorini; Cristina Cinti; F Pigliapoco; Silvia Deaglio; Enza Ferrero; Stefano Papa; F Palma
Rapid and sensitive detection of recombinant soluble proteins in the supernatant of transfected mammalian cells.
Journal of biological regulators and homeostatic agents 2002;16(2):93-7.
2002: Silvia Deaglio; Mercedes Zubiaur; Armando Gregorini; Flavia Bottarel; Clara Maria Ausiello; Umberto Dianzani; Jaime Sancho; Fabio Malavasi
Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells.
Blood 2002;99(7):2490-8.
2002: Fortunato Morabito; Massimo Mangiola; Caterina Stelitano; Silvia Deaglio; Vincenzo Callea; Fabio Malavasi
Peripheral blood CD38 expression predicts time to progression in B-cell chronic lymphocytic leukemia after first-line therapy with high-dose chlorambucil.
Haematologica 2002;87(2):217-8.
2001: Fortunato Morabito; Massimo Mangiola; Bianca Maria Oliva; Caterina Stelitano; Vincenzo Callea; Silvia Deaglio; Pasquale Iacopino; Maura Brugiatelli; Fabio Malavasi
Peripheral blood CD38 expression predicts survival in B-cell chronic lymphocytic leukemia.
Leukemia research 2001;25(11):927-32.
2001: Anna Sapino; Massimo Bongiovanni; Paola Cassoni; Luisella Righi; RICCARDO ARISIO; Silvia Deaglio; Fabio Malavasi
Expression of CD31 by cells of extensive ductal in situ and invasive carcinomas of the breast.
The Journal of pathology 2001;194(2):254-61.
2001: Tiziana Musso; Silvia Deaglio; L Franco; Liliana Calosso; Raffaele Badolato; Giovanni Garbarino; Umberto Dianzani; Fabio Malavasi
CD38 expression and functional activities are up-regulated by IFN-gamma on human monocytes and monocytic cell lines.
Journal of leukocyte biology 2001;69(4):605-12.
2001: Silvia Deaglio; Roberto Mallone; Germano Baj; D Donati; Giuseppe Giraudo; F Corno; S Bruzzone; Massimo Geuna; Clara Maria Ausiello; Fabio Malavasi
Human CD38 and its ligand CD31 define a unique lamina propria T lymphocyte signaling pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):580-2.
2001: Silvia Deaglio; D Canella; Germano Baj; Alberto Arnulfo; S Waxman; Fabio Malavasi
Evidence of an immunologic mechanism behind the therapeutical effects of arsenic trioxide (As(2)O(3)) on myeloma cells.
Leukemia research 2001;25(3):227-35.
2001: Paola Cassoni; Anna Sapino; Luca Munaron; Silvia Deaglio; Bice Chini; Andrea Graziani; A Ahmed; Gianni Bussolati
Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines.
Endocrinology 2001;142(3):1130-6.
2001: Paola Cassoni; Tiziana Marrocco; Silvia Deaglio; Anna Sapino; Gianni Bussolati
Biological relevance of oxytocin and oxytocin receptors in cancer cells and primary tumors.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12 Suppl 2():S37-9.
2001: Silvia Deaglio; K Mehta; Fabio Malavasi
Human CD38: a (r)evolutionary story of enzymes and receptors.
Leukemia research 2001;25(1):1-12.
2000: Clara Maria Ausiello; Francesca Urbani; Roberto Lande; Andrea la Sala; Beatrice Di Carlo; Germano Baj; Nicola Surico; J Hilgers; Silvia Deaglio; Ada Funaro; Fabio Malavasi
Functional topography of discrete domains of human CD38.
Tissue antigens 2000;56(6):539-47.
2000: Marie-Thérèse Zilber; S Gregory; Roberto Mallone; Silvia Deaglio; Fabio Malavasi; Dominique Charron; Catherine Gelin
CD38 expressed on human monocytes: a coaccessory molecule in the superantigen-induced proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2840-5.
2000: Paola Cassoni; Ezio Fulcheri; M L Carcangiu; A Stella; Silvia Deaglio; Gianni Bussolati
Oxytocin receptors in human adenocarcinomas of the endometrium: presence and biological significance.
The Journal of pathology 2000;190(4):470-7.
2000: Germano Baj; Alberto Arnulfo; Silvia Deaglio; Roberto Mallone; Alessandro Vigone; M Rosa; M Giana; L Villa; Fabio Malavasi; Nicola Surico
Retinoids in breast cancer prevention and treatment. A review of the literature.
European journal of gynaecological oncology 2000;21(4):411-5.
2000: Silvia Deaglio; Roberto Mallone; Germano Baj; Alberto Arnulfo; Nicola Surico; Umberto Dianzani; K Mehta; Fabio Malavasi
CD38/CD31, a receptor/ligand system ruling adhesion and signaling in human leukocytes.
Chemical immunology 2000;75():99-120.
1999: Antonella Vallario; Marco Chilosi; Fausto Adami; Licia Montagna; Silvia Deaglio; Fabio Malavasi; Federico Caligaris-Cappio
Human myeloma cells express the CD38 ligand CD31.
British journal of haematology 1999;105(2):441-4.
1999: Germano Baj; Alberto Arnulfo; Silvia Deaglio; Elena V Tibaldi; Nicola Surico; Fabio Malavasi
All-trans retinoic acid inhibits the growth of breast cancer cells by up-regulating ICAM-1 expression.
Journal of biological regulators and homeostatic agents 1999;13(2):115-22.
1998: J E Fernàndez; Silvia Deaglio; D Donati; I S Beusan; F Corno; A Aranega; M Forni; B Falini; Fabio Malavasi
Analysis of the distribution of human CD38 and of its ligand CD31 in normal tissues.
Journal of biological regulators and homeostatic agents 1998;12(3):81-91.
1998: Silvia Deaglio; Massimo Morra; Roberto Mallone; Clara Maria Ausiello; Elisabeth Prager; Giovanni Garbarino; Umberto Dianzani; Hannes Stockinger; Fabio Malavasi
Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):395-402.
1996: Silvia Deaglio; Umberto Dianzani; Alberto L Horenstein; J E Fernández; C van Kooten; M Bragardo; Ada Funaro; Giovanni Garbarino; F Di Virgilio; Jacques Banchereau; Fabio Malavasi
Human CD38 ligand. A 120-KDA protein predominantly expressed on endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):727-34.