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David Dean

Research Profile

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Gene Transfer Techniques

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Publications

TOP 3
M A Badding; E E Vaughan; David A Dean
Transcription factor plasmid binding modulates microtubule interactions and intracellular trafficking during gene transfer.
Xin Lin; David A Dean
Gene therapy for ALI/ARDS.
C D Kaufman; R. Christopher Geiger; David A Dean
Electroporation- and mechanical ventilation-mediated gene transfer to the lung.

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All Publications

2012: M A Badding; E E Vaughan; David A Dean
Transcription factor plasmid binding modulates microtubule interactions and intracellular trafficking during gene transfer.
Gene therapy 2012;19(3):338-46.
2011: Xin Lin; David A Dean
Gene therapy for ALI/ARDS.
Critical care clinics 2011;27(3):705-18.
2010: C D Kaufman; R. Christopher Geiger; David A Dean
Electroporation- and mechanical ventilation-mediated gene transfer to the lung.
Gene therapy 2010;17(9):1098-104.
2010: Anna Lam; David A Dean
Progress and prospects: nuclear import of nonviral vectors.
Gene therapy 2010;17(4):439-47.
2010: J V Degiulio; C D Kaufman; David A Dean
The SP-C promoter facilitates alveolar type II epithelial cell-specific plasmid nuclear import and gene expression.
Gene therapy 2010;17(4):541-9.
2009: Aaron M Miller; Felix M Munkonge; Eric W F W Alton; David A Dean
Identification of protein cofactors necessary for sequence-specific plasmid DNA nuclear import.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(11):1897-903.
2009: Gary L Aistrup; Roger Villuendas; Jason Ng; Annette Gilchrist; Thomas W Lynch; David Gordon; Ivan Cokic; Steven Mottl; Rui Zhou; David A Dean; J Andrew Wasserstrom; Jeffrey J Goldberger; Alan H Kadish; Rishi Arora
Targeted G-protein inhibition as a novel approach to decrease vagal atrial fibrillation by selective parasympathetic attenuation.
Cardiovascular research 2009;83(3):481-92.
2009: Aaron M Miller; David A Dean
Tissue-specific and transcription factor-mediated nuclear entry of DNA.
Advanced drug delivery reviews 2009;61(7-8):603-13.
2008: Erin Vaughan; R. Christopher Geiger; Aaron M Miller; Phoebe L Loh-Marley; Takayoshi Suzuki; Naoki Miyata; David A Dean
Microtubule acetylation through HDAC6 inhibition results in increased transfection efficiency.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(11):1841-7.
2008: A M Miller; David A Dean
Cell-specific nuclear import of plasmid DNA in smooth muscle requires tissue-specific transcription factors and DNA sequences.
Gene therapy 2008;15(15):1107-15.
2008: Anna Lam; David A Dean
Cyclic stretch-induced nuclear localization of transcription factors results in increased nuclear targeting of plasmids in alveolar epithelial cells.
The journal of gene medicine 2008;10(6):668-78.
2008: Rui Zhou; James E Norton; David A Dean
Electroporation-mediated gene delivery to the lungs.
Methods in molecular biology (Clifton, N.J.) 2008;423():233-47.
2007: Joshua Z Gasiorowski; David A Dean
Intranuclear trafficking of episomal DNA is transcription-dependent.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2132-9.
2007: Gökhan M Mutlu; David Green; Amy Bellmeyer; Christina M Baker; Zach Burgess; Nalini Rajamannan; John W Christman; Nancy Foiles; David W Kamp; Andrew J Ghio; Navdeep S Chandel; David A Dean; Jacob I Sznajder; G R Scott Budinger
Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway.
The Journal of clinical investigation 2007;117(10):2952-61.
2007: Gökhan M Mutlu; David Machado-Aranda; James E Norton; Amy Bellmeyer; Daniela Urich; Rui Zhou; David A Dean
Electroporation-mediated gene transfer of the Na+,K+ -ATPase rescues endotoxin-induced lung injury.
American journal of respiratory and critical care medicine 2007;176(6):582-90.
2007: Rui Zhou; J E Norton; N Zhang; David A Dean
Electroporation-mediated transfer of plasmids to the lung results in reduced TLR9 signaling and inflammation.
Gene therapy 2007;14(9):775-80.
2007: Amy Bellmeyer; Janice M Martino; Navdeep S Chandel; G R Scott Budinger; David A Dean; Gökhan M Mutlu
Leptin resistance protects mice from hyperoxia-induced acute lung injury.
American journal of respiratory and critical care medicine 2007;175(6):587-94.
2007: Rui Zhou; David A Dean
Gene transfer of interleukin 10 to the murine cornea using electroporation.
Experimental biology and medicine (Maywood, N.J.) 2007;232(3):362-9.
2007: K Kopp; Joshua Z Gasiorowski; D Chen; R Gilmore; J T Norton; C Wang; D J Leary; E K L Chan; David A Dean; S Huang
Pol I transcription and pre-rRNA processing are coordinated in a transcription-dependent manner in mammalian cells.
Molecular biology of the cell 2007;18(2):394-403.
2006: Erin Vaughan; James V DeGiulio; David A Dean
Intracellular trafficking of plasmids for gene therapy: mechanisms of cytoplasmic movement and nuclear import.
Current gene therapy 2006;6(6):671-81.
2006: R. Christopher Geiger; W Taylor; Matthew R Glucksberg; David A Dean
Cyclic stretch-induced reorganization of the cytoskeleton and its role in enhanced gene transfer.
Gene therapy 2006;13(8):725-31.
2006: Erin Vaughan; David A Dean
Intracellular trafficking of plasmids during transfection is mediated by microtubules.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(2):422-8.
2005: Joshua Z Gasiorowski; David A Dean
Postmitotic nuclear retention of episomal plasmids is altered by DNA labeling and detection methods.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(3):460-7.
2005: David A Dean
Nonviral gene transfer to skeletal, smooth, and cardiac muscle in living animals.
American journal of physiology. Cell physiology 2005;289(2):C233-45.
2005: Jonathan C R Jones; Kimberly Lane; Susan B Hopkinson; Emilia Lecuona; R. Christopher Geiger; David A Dean; Eduardo Correa-Meyer; Meredith Gonzales; Kevin Campbell; Jacob I Sznajder; Scott Budinger
Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism.
Journal of cell science 2005;118(Pt 12):2557-66.
2005: David A Dean; Donna Strong; Warren Zimmer
Nuclear entry of nonviral vectors.
Gene therapy 2005;12(11):881-90.
2005: David Machado-Aranda; Yochai Adir; Jennifer L Young; Arturo Briva; G R Scott Budinger; Anjana V Yeldandi; Jacob I Sznajder; David A Dean
Gene transfer of the Na+,K+-ATPase beta1 subunit using electroporation increases lung liquid clearance.
American journal of respiratory and critical care medicine 2005;171(3):204-11.
2004: Rui Zhou; R. Christopher Geiger; David A Dean
Intracellular trafficking of nucleic acids.
Expert opinion on drug delivery 2004;1(1):127-40.
2004: Guisheng Zhang; Xiang Gao; Young K Song; R Vollmer; DB Stolz; Joshua Z Gasiorowski; David A Dean; Dexi Liu
Hydroporation as the mechanism of hydrodynamic delivery.
Gene therapy 2004;11(8):675-82.
2003: David A Dean
Electroporation of the vasculature and the lung.
DNA and cell biology 2003;22(12):797-806.
2003: Elizabeth A Nunamaker; Hai-Ying Zhang; Yuichi Shirasawa; Joseph N Benoit; David A Dean
Electroporation-mediated delivery of catalytic oligodeoxynucleotides for manipulation of vascular gene expression.
American journal of physiology. Heart and circulatory physiology 2003;285(5):H2240-7.
2003: David A Dean; David Machado-Aranda; K Blair-Parks; Anjana V Yeldandi; Jennifer L Young
Electroporation as a method for high-level nonviral gene transfer to the lung.
Gene therapy 2003;10(18):1608-15.
2003: Jennifer L Young; Joseph N Benoit; David A Dean
Effect of a DNA nuclear targeting sequence on gene transfer and expression of plasmids in the intact vasculature.
Gene therapy 2003;10(17):1465-70.
2003: Joshua Z Gasiorowski; David A Dean
Mechanisms of nuclear transport and interventions.
Advanced drug delivery reviews 2003;55(6):703-16.
2003: Yuichi Shirasawa; Travis J Rutland; Jennifer L Young; David A Dean; Benoit N Joseph
Modulation of protein kinase C (PKC)-mediated contraction and the possible role of PKC epsilon in rat mesenteric arteries.
Frontiers in bioscience : a journal and virtual library 2003;8():a133-8.
2003: Winna Taylor; Kerimi E Gokay; Chris Capaccio; Erica Davis; Matthew R Glucksberg; David A Dean
The effects of cyclic stretch on gene transfer in alveolar epithelial cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(4):542-9.
2002: G R Scott Budinger; May Tso; David S McClintock; David A Dean; Jacob I Sznajder; Navdeep S Chandel
Hyperoxia-induced apoptosis does not require mitochondrial reactive oxygen species and is regulated by Bcl-2 proteins.
The Journal of biological chemistry 2002;277(18):15654-60.
2002: Karen K Hirschi; Lihua Lai; Narasimhaswamy S Belaguli; David A Dean; Robert J Schwartz; Warren Zimmer
Transforming growth factor-beta induction of smooth muscle cell phenotpye requires transcriptional and post-transcriptional control of serum response factor.
The Journal of biological chemistry 2002;277(8):6287-95.
2002: R A Filmore; David A Dean; Warren Zimmer
The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia.
Gene expression 2002;10(5-6):201-11.
2002: Jennifer L Young; David A Dean
Nonviral gene transfer strategies for the vasculature.
Microcirculation (New York, N.Y. : 1994) 2002;9(1):35-49.
2002: Kathleen Blair-Parks; Bonnie C Weston; David A Dean
High-level gene transfer to the cornea using electroporation.
The journal of gene medicine 2002;4(1):92-100.
2000: David A Dean
Peptide nucleic acids: versatile tools for gene therapy strategies.
Advanced drug delivery reviews 2000;44(2-3):81-95.
2000: J B Martin; Jennifer L Young; Joseph N Benoit; David A Dean
Gene transfer to intact mesenteric arteries by electroporation.
Journal of vascular research 2000;37(5):372-80.
1999: David A Dean; BS Dean; S Muller; L C Smith
Sequence requirements for plasmid nuclear import.
Experimental cell research 1999;253(2):713-22.
1999: Glenn L Wilson; BS Dean; G Wang; David A Dean
Nuclear import of plasmid DNA in digitonin-permeabilized cells requires both cytoplasmic factors and specific DNA sequences.
The Journal of biological chemistry 1999;274(31):22025-32.
1999: David A Dean; J N Byrd; BS Dean
Nuclear targeting of plasmid DNA in human corneal cells.
Current eye research 1999;19(1):66-75.
1999: G Wang; Xiaoxin Susan Xu; Betty S Pace; David A Dean; Peter M Glazer; P Chan; Steven R Goodman; Inna N Shokolenko
Peptide nucleic acid (PNA) binding-mediated induction of human gamma-globin gene expression.
Nucleic acids research 1999;27(13):2806-13.
1999: J Vacik; BS Dean; Warren Zimmer; David A Dean
Cell-specific nuclear import of plasmid DNA.
Gene therapy 1999;6(6):1006-14.
1997: David A Dean
Import of plasmid DNA into the nucleus is sequence specific.
Experimental cell research 1997;230(2):293-302.