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Klaus-Michael Debatin

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L Wagner; Kerry Zobel; S Karl; V Marschall; D Vucic; Silvia Cristofanon; Klaus-Michael Debatin; Kurt Deshayes; Simone Fulda
Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner.
Stefanie Enzenmüller; Patrick Gonzalez; Georg Karpel-Massler; Klaus-Michael Debatin; Simone Fulda
GDC-0941 enhances the lysosomal compartment via TFEB and primes glioblastoma cells to lysosomal membrane permeabilization and cell death.
Natalie Hartmann; Michael Kluge; Frank Leithäuser; Joanna J Messmann; Klaus-Michael Debatin; Harald Fricke; Maxi Weiswange; Gudrun Strauss
Recombinant CD95-Fc (APG101) prevents graft-versus-host disease in mice without disabling antitumor cytotoxicity and T-cell functions.

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2013: L Wagner; Kerry Zobel; S Karl; V Marschall; D Vucic; Silvia Cristofanon; Klaus-Michael Debatin; Kurt Deshayes; Simone Fulda
Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner.
Oncogene 2013;32(8):988-97.
2013: Stefanie Enzenmüller; Patrick Gonzalez; Georg Karpel-Massler; Klaus-Michael Debatin; Simone Fulda
GDC-0941 enhances the lysosomal compartment via TFEB and primes glioblastoma cells to lysosomal membrane permeabilization and cell death.
Cancer letters 2013;329(1):27-36.
2013: Natalie Hartmann; Michael Kluge; Frank Leithäuser; Joanna J Messmann; Klaus-Michael Debatin; Harald Fricke; Maxi Weiswange; Gudrun Strauss
Recombinant CD95-Fc (APG101) prevents graft-versus-host disease in mice without disabling antitumor cytotoxicity and T-cell functions.
Blood 2013;121(3):556-65.
2013: Shobhit Saxena; Dominic Stadel; Joachim Wahl; Peter Braubach; Klaus-Michael Debatin; Markus Huber-Lang; Christian Beltinger
Generation of murine sympathoadrenergic progenitor-like cells from embryonic stem cells and postnatal adrenal glands.
PloS one 2013;8(5):e64454.
2013: M Keuper; Peter Möller; P E Scherer; G Strauss; Martin Wabitsch; I Wernstedt Asterholm; Mike-Andrew Westhoff; Klaus-Michael Debatin; Pamela Fischer-Posovszky
TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma.
Cell death & disease 2013;4():e474.
2013: Stefanie Enzenmüller; Klaus-Michael Debatin; Patrick Gonzalez; Simone Fulda
Chloroquine overcomes resistance of lung carcinoma cells to the dual PI3K/mTOR inhibitor PI103 by lysosome-mediated apoptosis.
Anti-cancer drugs 2013;24(1):14-9.
2012: A Bangert; Silvia Cristofanon; Klaus-Michael Debatin; I Eckhardt; S Häcker; S Kolodziej; J Lausen; S H K Vellanki; B A Abhari; Mehtap Kilic
Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP.
Oncogene 2012;31(44):4677-88.
2012: Pamela Fischer-Posovszky; Sina Horenburg; Daniel Tews; Klaus-Michael Debatin; Martin Wabitsch
Differential function of Akt1 and Akt2 in human adipocytes.
Molecular and cellular endocrinology 2012;358(1):135-43.
2012: Bernd Gruhn; Norman Klöppner; Nadine Pfaffendorf-Regler; Stephan Bartholomä; James Beck; Klaus-Michael Debatin; Felix Zintl; Daniel Steinbach
Toll-like 4 receptor variant, Asp299Gly, and reduced risk of hemorrhagic cystitis after hematopoietic stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2012;18(6):958-63.
2012: Jochen Tuettenberg; Michael von Staden; Marcel Seiz; Meinolf Thiemann; Klaus-Michael Debatin; Harald Fricke; Barbara Hareng; Wiebke Hollburg; Claudia Kunz
Pharmacokinetics, pharmacodynamics, safety and tolerability of APG101, a CD95-Fc fusion protein, in healthy volunteers and two glioma patients.
International immunopharmacology 2012;13(1):93-100.
2012: S Löder; H Schoeneberger; P Vandenabeele; N Vanlangenakker; M J M Bertrand; Silvia Cristofanon; Klaus-Michael Debatin; M Fakler; Irmela Jeremias; J Leibacher; Mehtap Kilic
RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis.
Leukemia 2012;26(5):1020-9.
2012: C Jennewein; S Karl; O Micheau; B Baumann; Klaus-Michael Debatin; Mehtap Kilic
Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells.
Oncogene 2012;31(11):1468-74.
2012: C Posovszky; C Schröder; A Schulz; C Schütz; J von Schnurbein; Martin Wabitsch; Stephan Buderus; Klaus-Michael Debatin; A Findeisen; G Lahr; Thomas F E Barth
Loss of enteroendocrine cells in autoimmune-polyendocrine-candidiasis-ectodermal-dystrophy (APECED) syndrome with gastrointestinal dysfunction.
The Journal of clinical endocrinology and metabolism 2012;97(2):E292-300.
2012: Manfred Hönig; E Jacobsen; G Lahr; Markus T Rojewski; C Schuetz; Ansgar Schulz; Klaus Schwarz; Klaus-Michael Debatin; Wilhelm Friedrich
Immunological reconstitution in a patient with ZAP-70 deficiency following transfusion of blood lymphocytes from a previously transplanted sibling without conditioning.
Bone marrow transplantation 2012;47(2):305-7.
2012: Anne-Marie Schlitter; Johannes H Schulte; Joachim Wahl; Thomas F E Barth; Silke Brüderlein; Klaus-Michael Debatin; Carmen Dorneburg; Christian Beltinger
CD57(high) neuroblastoma cells have aggressive attributes ex situ and an undifferentiated phenotype in patients.
PloS one 2012;7(8):e42025.
2012: M Queudeville; M Schirmer; F Seyfried; L Trentin; S Ulrich; Klaus-Michael Debatin; S M Eckhoff; Lüder Hinrich Meyer
Rapid engraftment of human ALL in NOD/SCID mice involves deficient apoptosis signaling.
Cell death & disease 2012;3():e364.
2011: Lüder Hinrich Meyer; Klaus-Michael Debatin
Diversity of human leukemia xenograft mouse models: implications for disease biology.
Cancer research 2011;71(23):7141-4.
2011: Daniel Steinbach; Brigitte Strahm; Arend von Stackelberg; Bernhard Wilhelm; Martin Zimmermann; Ursula Creutzig; Klaus-Michael Debatin; Bernd Gruhn; Heribert Jürgens; Hans-Rudolf Kiermaier; Dirk Reinhardt; Martin Schrappe; Anja Möricke
Long term survival in children with acute leukaemia and complications requiring mechanical ventilation.
Archives of disease in childhood 2011;96(11):1026-32.
2011: Rebecca Berger; Silvia Cristofanon; Klaus-Michael Debatin; Stephanie Hehlgans; Claudia Jennewein; Sabine Karl; Albert C Ludolph; Viola Marschall; Franz Rödel; Sri HariKrishna Vellanki; Liane Wagner; Simone Fulda
NF-κB is required for Smac mimetic-mediated sensitization of glioblastoma cells for γ-irradiation-induced apoptosis.
Molecular cancer therapeutics 2011;10(10):1867-75.
2011: M Malaisé; M Neumeier; Dirk Reinhardt; Brigitte Schlegelberger; Klaus-Michael Debatin; K Döhner; G Göhring; Bernd Gruhn; Catherine Botteron; Selim Corbacioglu
Stable and reproducible engraftment of primary adult and pediatric acute myeloid leukemia in NSG mice.
Leukemia 2011;25(10):1635-9.
2011: Annette Bangert; Sabine Häcker; Silvia Cristofanon; Klaus-Michael Debatin; Simone Fulda
Chemosensitization of glioblastoma cells by the histone deacetylase inhibitor MS275.
Anti-cancer drugs 2011;22(6):494-9.
2011: D Fabricius; Mehtap Kilic; Bernd Jahrsdörfer; L Breckerbohm; Klaus-Michael Debatin; S M Eckhoff; M Queudeville; G Strauss; A Vollmer; Lüder Hinrich Meyer
Acute lymphoblastic leukemia cells treated with CpG oligodeoxynucleotides, IL-4 and CD40 ligand facilitate enhanced anti-leukemic CTL responses.
Leukemia 2011;25(7):1111-21.
2011: Thomas Unterkircher; Sri Hari Krishna Vellanki; Christian Rainer Wirtz; Silvia Cristofanon; Klaus-Michael Debatin; Georg Karpel-Massler; Lisa Nonnenmacher; Simone Fulda
Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(12):4019-30.
2011: Michaela Keuper; Peter Möller; Michael R Schön; Martin Wabitsch; Kurt Amrein; Matthias Blüher; Klaus-Michael Debatin; Anna Dzyakanchuk; Pamela Fischer-Posovszky
An inflammatory micro-environment promotes human adipocyte apoptosis.
Molecular and cellular endocrinology 2011;339(1-2):105-13.
2011: Ivonne Naumann; Roland Kappler; Dietrich von Schweinitz; Klaus-Michael Debatin; Simone Fulda
Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(10):3204-18.
2011: Daniela Opel; Ivonne Naumann; Maxi Schneider; Daniela Bertele; Klaus-Michael Debatin; Simone Fulda
Targeting aberrant PI3K/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(10):3233-47.
2011: S Häcker; S Karl; I Mader; S Cristofanon; T Schweitzer; J Krauss; S Rutkowski; Klaus-Michael Debatin; Mehtap Kilic
Histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent Bax activation.
Oncogene 2011;30(19):2275-81.
2011: U Dieluweit; T Besier; Klaus-Michael Debatin; D Grabow; Peter Kaatsch; D C M Seitz; Lutz Goldbeck
Utilization of psychosocial care and oncological follow-up assessments among German long-term survivors of cancer with onset during adolescence.
Klinische Pädiatrie 2011;223(3):152-8.
2011: N Hartmann; F Leithäuser; C Albers; J Duyster; P Möller; Klaus-Michael Debatin; G Strauss
In vitro-established alloantigen-specific CD8+ CTLs mediate graft-versus-tumor activity in the absence of graft-versus-host disease.
Leukemia 2011;25(5):848-55.
2011: Ansgar S Schulz; Gerhard Glatting; Manfred Hoenig; Catharina Schuetz; Susanne A Gatz; Simon Grewendorf; Monika Sparber-Sauer; Rainer Muche; Norbert Blumstein; Gabriele Kropshofer; Meinolf Suttorp; Donald Bunjes; Klaus-Michael Debatin; Sven N Reske; Wilhelm Friedrich
Radioimmunotherapy-based conditioning for hematopoietic cell transplantation in children with malignant and nonmalignant diseases.
Blood 2011;117(17):4642-50.
2011: Ute Dieluweit; Klaus-Michael Debatin; Desiree Grabow; Peter Kaatsch; Richard Peter; Diana C M Seitz; Lutz Goldbeck
Educational and vocational achievement among long-term survivors of adolescent cancer in Germany.
Pediatric blood & cancer 2011;56(3):432-8.
2011: Diana C M Seitz; Daniela Hagmann; Tanja Besier; Ute Dieluweit; Klaus-Michael Debatin; Desiree Grabow; Peter Kaatsch; Gerhard Henrich; Lutz Goldbeck
Life satisfaction in adult survivors of cancer during adolescence: what contributes to the latter satisfaction with life?
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 2011;20(2):225-36.
2011: Lüder Hinrich Meyer; Sarah Mirjam Eckhoff; Manon Queudeville; Johann Michael Kraus; Marco Giordan; Jana Stursberg; Andrea Zangrando; Elena Vendramini; Anja Möricke; Martin Zimmermann; Andre Schrauder; G Lahr; Karlheinz Holzmann; Martin Schrappe; Giuseppe Basso; Karsten Stahnke; Hans Armin Kestler; Geertruy Te Kronnie; Klaus-Michael Debatin
Early relapse in ALL is identified by time to leukemia in NOD/SCID mice and is characterized by a gene signature involving survival pathways.
Cancer cell 2011;19(2):206-17.
2011: Holger Cario; Desirée E C Smith; Henk Blom; Nenad Blau; Harald Bode; Karlheinz Holzmann; Ulrich Pannicke; Karl-Peter Hopfner; Eva-Maria Rump; Zuleya Ayric; Elisabeth Kohne; Klaus-Michael Debatin; Yvo Smulders; Klaus Schwarz
Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease.
American journal of human genetics 2011;88(2):226-31.
2011: Christian Haag; Dominic Stadel; Shaoxia Zhou; Max G Bachem; Peter Möller; Klaus-Michael Debatin; Simone Fulda
Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells.
Gut 2011;60(2):225-37.
2011: A Bender; D Opel; I Naumann; R Kappler; L Friedman; D von Schweinitz; Klaus-Michael Debatin; S Fulda
PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis.
Oncogene 2011;30(4):494-503.
2010: Dominic Stadel; Andrea Mohr; Caroline Ref; Marion MacFarlane; Shaoxia Zhou; Robin Humphreys; Max G Bachem; Gerry Cohen; Peter Möller; Ralf Michael Zwacka; Klaus-Michael Debatin; Simone Fulda
TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(23):5734-49.
2010: Ute Dieluweit; Klaus-Michael Debatin; Desiree Grabow; Peter Kaatsch; Richard Peter; Diana C M Seitz; Lutz Goldbeck
Social outcomes of long-term survivors of adolescent cancer.
Psycho-oncology 2010;19(12):1277-84.
2010: J Wahl; Liubov Bogatyreva; Petra Boukamp; Markus Rojewski; Frans van Valen; Jörg Fiedler; Nora Hipp; Klaus-Michael Debatin; Christian Beltinger
Ewing's sarcoma cells with CD57-associated increase of tumorigenicity and with neural crest-like differentiation capacity.
International journal of cancer. Journal international du cancer 2010;127(6):1295-307.
2010: Pamela Fischer-Posovszky; Vera Kukulus; Daniel Tews; Thomas Unterkircher; Klaus-Michael Debatin; Simone Fulda; Martin Wabitsch
Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner.
The American journal of clinical nutrition 2010;92(1):5-15.
2010: Pamela Fischer-Posovszky; Julia von Schnurbein; Barbara Moepps; G Lahr; Gudrun Strauss; Thomas F E Barth; Jan Kassubek; Hannes Mühleder; Peter Möller; Klaus-Michael Debatin; Peter Gierschik; Martin Wabitsch
A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness.
The Journal of clinical endocrinology and metabolism 2010;95(6):2836-40.
2010: Diana C M Seitz; Tanja Besier; Klaus-Michael Debatin; Desiree Grabow; Ute Dieluweit; Andreas Hinz; Peter Kaatsch; Lutz Goldbeck
Posttraumatic stress, depression and anxiety among adult long-term survivors of cancer in adolescence.
European journal of cancer (Oxford, England : 1990) 2010;46(9):1596-606.
2010: Isabelle Mader; Martin Wabitsch; Klaus-Michael Debatin; Pamela Fischer-Posovszky; Simone Fulda
Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(6):1997-2009.
2010: Sandra Loeder; Annekathrin Drensek; Irmela Jeremias; Klaus-Michael Debatin; Simone Fulda
Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis.
International journal of cancer. Journal international du cancer 2010;126(9):2216-28.
2010: Bernd Jahrsdörfer; Angelika Vollmer; Sue E Blackwell; Julia Maier; Kai Sontheimer; Thamara Beyer; Birgit Mandel; Oleg Lunov; Kyrylo Tron; G Ulrich Nienhaus; Thomas Simmet; Klaus-Michael Debatin; George J Weiner; Dorit Fabricius
Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion.
Blood 2010;115(6):1156-65.
2010: Dorit Fabricius; Marina Neubauer; Birgit Mandel; Catharina Schütz; Andreas Viardot; Angelika Vollmer; Bernd Jahrsdörfer; Klaus-Michael Debatin
Prostaglandin E2 inhibits IFN-alpha secretion and Th1 costimulation by human plasmacytoid dendritic cells via E-prostanoid 2 and E-prostanoid 4 receptor engagement.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(2):677-84.
2009: Sandra Loeder; Thorsten Zenz; Andrea Schnaiter; Daniel Mertens; Dirk Winkler; Hartmut Döhner; Klaus-Michael Debatin; Stephan Stilgenbauer; Simone Fulda
A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia.
Cancer research 2009;69(23):8977-86.
2009: Bernd Gruhn; Juliane Intek; Nadine Pfaffendorf; Roland Zell; Selim Corbacioglu; Felix Zintl; James F Beck; Klaus-Michael Debatin; Daniel Steinbach
Polymorphism of interleukin-23 receptor gene but not of NOD2/CARD15 is associated with graft-versus-host disease after hematopoietic stem cell transplantation in children.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009;15(12):1571-7.
2009: M J Ege; Lüder Hinrich Meyer; Klaus-Michael Debatin; Karsten Stahnke
Coincidence of recurrent hemiparesis and detection of ALL in a 4-year-old girl: one or two diseases?
Klinische Pädiatrie 2009;221(6):386-9.
2009: Klaus-Michael Debatin
Growth control of normal and malignant lymphocytes--cell death research from basic concepts to signal pathways and translation into the clinic.
Klinische Pädiatrie 2009;221(6):332-8.
2009: Mike-Andrew Westhoff; J A Kandenwein; S Karl; S H K Vellanki; V Braun; A Eramo; G Antoniadis; Klaus-Michael Debatin; Mehtap Kilic
The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair.
Oncogene 2009;28(40):3586-96.
2009: Sabine Karl; Yvonne Pritschow; Meta Volcic; Sabine Häcker; Bernd Baumann; Lisa Wiesmüller; Klaus-Michael Debatin; Simone Fulda
Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response.
Journal of cellular and molecular medicine 2009;13(10):4239-56.
2009: M Sparber-Sauer; Manfred Hönig; Ansgar S Schulz; U zur Stadt; C Schütz; Klaus-Michael Debatin; Wilhelm Friedrich
Patients with early relapse of primary hemophagocytic syndromes or with persistent CNS involvement may benefit from immediate hematopoietic stem cell transplantation.
Bone marrow transplantation 2009;44(6):333-8.
2009: Sri Hari Krishna Vellanki; Andreas Grabrucker; Stefan Liebau; Christian Proepper; Adriana Eramo; Veit Braun; Tobias Boeckers; Klaus-Michael Debatin; Simone Fulda
Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma.
Neoplasia (New York, N.Y.) 2009;11(8):743-52.
2009: Gudrun Strauss; Jonathan A Lindquist; Nathalie Arhel; Edward Felder; Sabine Karl; Tobias L Haas; Simone Fulda; Henning Walczak; Frank Kirchhoff; Klaus-Michael Debatin
CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling.
The Journal of experimental medicine 2009;206(6):1379-93.
2009: Thorsten Schinke; Arndt F Schilling; Anke Baranowsky; Sebastian Seitz; Robert P Marshall; Tilman Linn; Michael Blaeker; Antje K Huebner; Ansgar Schulz; Ronald Simon; Matthias Gebauer; Matthias Priemel; Uwe Kornak; Sandra Perkovic; Florian Barvencik; F Timo Beil; Andrea Del Fattore; Annalisa Frattini; Thomas Streichert; Klaus Pueschel; Anna Villa; Klaus-Michael Debatin; Johannes M Rueger; Anna Teti; Jozef Zustin; Guido Sauter; Michael Amling
Impaired gastric acidification negatively affects calcium homeostasis and bone mass.
Nature medicine 2009;15(6):674-81.
2009: Meike Vogler; Henning Walczak; Dominic Stadel; Tobias L Haas; Felicitas Genze; Marjana Jovanovic; Umesh K Bhanot; Cornelia Hasel; Peter Möller; Juergen E Gschwend; Thomas Simmet; Klaus-Michael Debatin; Simone Fulda
Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma.
Cancer research 2009;69(6):2425-34.
2009: Johannes U Ammann; Christian Haag; Hubert Kasperczyk; Klaus-Michael Debatin; Simone Fulda
Sensitization of neuroblastoma cells for TRAIL-induced apoptosis by NF-kappaB inhibition.
International journal of cancer. Journal international du cancer 2009;124(6):1301-11.
2009: Melanie Fakler; Sandra Loeder; Meike Vogler; Katja Schneider; Irmela Jeremias; Klaus-Michael Debatin; Simone Fulda
Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance.
Blood 2009;113(8):1710-22.
2009: Hans Fuchs; Carsten Posovszky; G Lahr; Jutte van der Werff Ten Bosch; Thomas Boehler; Klaus-Michael Debatin
Residual CD95-pathway function in children with autoimmune lymphoproliferative syndrome is independent from clinical state and genotype of CD95 mutation.
Pediatric research 2009;65(2):163-8.
2009: Hubert Kasperczyk; Bernd Baumann; Klaus-Michael Debatin; Simone Fulda
Characterization of sonic hedgehog as a novel NF-kappaB target gene that promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(1):21-33.
2008: S Horenburg; Pamela Fischer-Posovszky; Klaus-Michael Debatin; Martin Wabitsch
Influence of sex hormones on adiponectin expression in human adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2008;40(11):779-86.
2008: J von Schnurbein; G Lahr; C Posovszky; Klaus-Michael Debatin; Martin Wabitsch
Novel homozygous AIRE mutation in a German patient with severe APECED.
Journal of pediatric endocrinology & metabolism : JPEM 2008;21(10):1003-9.
2008: Meike Vogler; Henning Walczak; Dominic Stadel; Tobias L Haas; Felicitas Genze; Marjana Jovanovic; Juergen E Gschwend; Thomas Simmet; Klaus-Michael Debatin; Simone Fulda
Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic cancer growth in vitro and in vivo.
Cancer research 2008;68(19):7956-65.
2008: Bernd Gruhn; Jeffrey W Taub; Yubin Ge; J F Beck; R Zell; Ralf Häfer; F H Hermann; Klaus-Michael Debatin; Daniel Steinbach
Prenatal origin of childhood acute lymphoblastic leukemia, association with birth weight and hyperdiploidy.
Leukemia 2008;22(9):1692-7.
2008: C Friesen; A Lubatschofski; Gerhard Glatting; Klaus-Michael Debatin; Sven N Reske
Activation of intrinsic apoptotic pathway by Re-188 irradiation and paclitaxel in coronary artery smooth muscle cells.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology 2008;52(3):289-95.
2008: Daniela Opel; Mike-Andrew Westhoff; Ariane Bender; Veit Braun; Klaus-Michael Debatin; Simone Fulda
Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis.
Cancer research 2008;68(15):6271-80.
2008: Holger Cario; Klaus Schwarz; Jan M Herter; Vladimir Komrska; Mary F McMullin; Milen Minkov; Charlotte Niemeyer; Dagmar Pospisilova; Harald Reinhard; Klaus-Michael Debatin; Heike L Pahl
Clinical and molecular characterisation of a prospectively collected cohort of children and adolescents with polycythemia vera.
British journal of haematology 2008;142(4):622-6.
2008: Claudia Friesen; Miriam Uhl; Ulrich Pannicke; Klaus Schwarz; Erich Miltner; Klaus-Michael Debatin
DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin.
Molecular biology of the cell 2008;19(8):3283-9.
2008: Alexey Ushmorov; M D Hogarty; X Liu; H Knauss; Klaus-Michael Debatin; Christian Beltinger
N-myc augments death and attenuates protective effects of Bcl-2 in trophically stressed neuroblastoma cells.
Oncogene 2008;27(24):3424-34.
2008: Klaus-Michael Debatin; Jiwu Wei; Christian Beltinger
Endothelial progenitor cells for cancer gene therapy.
Gene therapy 2008;15(10):780-6.
2008: Beate Karges; Rainer Muche; M Moritz; I Riegger; Klaus-Michael Debatin; Eberhard Heinze; Martin Wabitsch; Wolfram Karges
Low discomfort and pain associated with intensified insulin therapy in children and adolescents.
Diabetes research and clinical practice 2008;80(1):96-101.
2008: Susanne Andrea Gatz; Marlen Keimling; Cindy Baumann; Thilo Dörk; Klaus-Michael Debatin; Simone Fulda; Lisa Wiesmüller
Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner.
Carcinogenesis 2008;29(3):519-27.
2008: Lüder Hinrich Meyer; Manon Queudeville; Sarah M Eckhoff; Ursula Creutzig; Dirk Reinhardt; Leonid Karawajew; Wolf-Dieter Ludwig; Karsten Stahnke; Klaus-Michael Debatin
Intact apoptosis signaling in myeloid leukemia cells determines treatment outcome in childhood AML.
Blood 2008;111(5):2899-903.
2008: G Strauss; Mike-Andrew Westhoff; Pamela Fischer-Posovszky; Simone Fulda; M Schanbacher; S M Eckhoff; Karsten Stahnke; N Vahsen; G Kroemer; Klaus-Michael Debatin
4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG.
Cell death and differentiation 2008;15(2):332-43.
2008: Katrin Schmidt; Ansgar Stephan Schulz; Klaus-Michael Debatin; Wilhelm Friedrich; Carl Friedrich Classen
CNS complications in children receiving chemotherapy or hematopoietic stem cell transplantation: retrospective analysis and clinical study of survivors.
Pediatric blood & cancer 2008;50(2):331-6.
2008: Harald Ehrhardt; S Häcker; S Wittmann; M Maurer; A Borkhardt; A Toloczko; Klaus-Michael Debatin; Simone Fulda; Irmela Jeremias
Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells.
Oncogene 2008;27(6):783-93.
2007: Jiwu Wei; J Wahl; T Nakamura; D Stiller; T Mertens; Klaus-Michael Debatin; Christian Beltinger
Targeted release of oncolytic measles virus by blood outgrowth endothelial cells in situ inhibits orthotopic gliomas.
Gene therapy 2007;14(22):1573-86.
2007: Stavros Giagkousiklidis; S H Vellanki; Klaus-Michael Debatin; Simone Fulda
Sensitization of pancreatic carcinoma cells for gamma-irradiation-induced apoptosis by XIAP inhibition.
Oncogene 2007;26(49):7006-16.
2007: C Schuetz; Gotthold Barbi; Thomas F E Barth; M Hoenig; A Schulz; P Möeller; Dominique Smeets; JC de Greef; S M van der Maarel; Walther Vogel; Klaus-Michael Debatin; Wilhelm Friedrich
ICF syndrome: high variability of the chromosomal phenotype and association with classical Hodgkin lymphoma.
American journal of medical genetics. Part A 2007;143A(17):2052-7.
2007: Jiwu Wei; J Wahl; H Knauss; S Zeller; Gergely Jarmy; G Fitze; Klaus-Michael Debatin; Christian Beltinger
Cytosine deaminase/5-fluorocytosine gene therapy and Apo2L/TRAIL cooperate to kill TRAIL-resistant tumor cells.
Cancer gene therapy 2007;14(7):640-51.
2007: Klaus-Michael Debatin
Chronic lymphocytic leukemia: keeping cell death at bay.
Cell 2007;129(5):853-5.
2007: Beate Karges; Carsten Bergmann; Katrina Scholl; Eberhard Heinze; Franz Maximilian Rasche; Klaus Zerres; Klaus-Michael Debatin; Martin Wabitsch; Wolfram Karges
Digenic inheritance of hepatocyte nuclear factor-1alpha and -1beta with maturity-onset diabetes of the young, polycystic thyroid, and urogenital malformations.
Diabetes care 2007;30(6):1613-4.
2007: Jiwu Wei; Shaoxia Zhou; Max G Bachem; Klaus-Michael Debatin; Christian Beltinger
Infiltration of blood outgrowth endothelial cells into tumor spheroids: role of matrix metalloproteinases and irradiation.
Anticancer research 2007;27(3B):1415-21.
2007: Susana Rives; Heike L Pahl; Lourdes Florensa; Beatriz Bellosillo; Andrea Neusuess; Jesús Estella; Klaus-Michael Debatin; Elisabeth Kohne; Klaus Schwarz; Holger Cario
Molecular genetic analyses in familial and sporadic congenital primary erythrocytosis.
Haematologica 2007;92(5):674-7.
2007: Beate Karges; Rainer Muche; Ina Knerr; Waldemar Ertelt; Thomas Wiesel; Regine Hub; Andreas Neu; Albrecht Klinghammer; Julia Aufschild; Andrea Rapp; Andreas Schirbel; Bernhard O Boehm; Klaus-Michael Debatin; Eberhard Heinze; Wolfram Karges
Levothyroxine in euthyroid autoimmune thyroiditis and type 1 diabetes: a randomized, controlled trial.
The Journal of clinical endocrinology and metabolism 2007;92(5):1647-52.
2007: Manfred Hönig; Michael H Albert; Ansgar Schulz; Monika Sparber-Sauer; Catharina Schütz; Bernd H Belohradsky; Tayfun Güngör; Markus T Rojewski; Harald Bode; Ulrich Pannicke; Dominique Lippold; Klaus Schwarz; Klaus-Michael Debatin; Michael S Hershfield; Wilhelm Friedrich
Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications.
Blood 2007;109(8):3595-602.
2007: Simone Fulda; Klaus-Michael Debatin
HIF-1-regulated glucose metabolism: a key to apoptosis resistance?
Cell cycle (Georgetown, Tex.) 2007;6(7):790-2.
2007: M Kilic; Hubert Kasperczyk; Mehtap Kilic; Klaus-Michael Debatin
Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance.
Oncogene 2007;26(14):2027-38.
2007: Pamela Fischer-Posovszky; V Kukulus; M A Zulet; Klaus-Michael Debatin; Martin Wabitsch
Conjugated linoleic acids promote human fat cell apoptosis.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2007;39(3):186-91.
2007: Claudia Friesen; Gerhard Glatting; Bernd Koop; Klaus Schwarz; Alfred Morgenstern; Christos Apostolidis; Klaus-Michael Debatin; Sven N Reske
Breaking chemoresistance and radioresistance with [213Bi]anti-CD45 antibodies in leukemia cells.
Cancer research 2007;67(5):1950-8.
2007: Till Wenger; Jürgen Mattern; Tobias L Haas; Martin Sprick; Henning Walczak; Klaus-Michael Debatin; Markus W Büchler; Ingrid Herr
Apoptosis mediated by lentiviral TRAIL transfer involves transduction-dependent and -independent effects.
Cancer gene therapy 2007;14(3):316-26.
2007: G Strauss; W Osen; I Knape; E-M Jacobsen; S M Müller; Klaus-Michael Debatin
Membrane-bound CD95 ligand expressed on human antigen-presenting cells prevents alloantigen-specific T cell response without impairment of viral and third-party T cell immunity.
Cell death and differentiation 2007;14(3):480-8.
2007: Chengwen Zhang; Till Wenger; Jürgen Mattern; Septimia Ilea; Christian R Frey; Paul Gutwein; Peter Altevogt; Wolfram Bodenmüller; Nikolaus Gassler; Philipp A Schnabel; Hendrik Dienemann; Alexander Marmé; Markus Hohenfellner; Axel Haferkamp; Jesco Pfitzenmaier; Hermann-Josef Gröne; Armin Kolb; Peter Büchler; Markus Büchler; Helmut Friess; Werner Rittgen; Lutz Edler; Klaus-Michael Debatin; Peter H Krammer; Hans Peter Rutz; Ingrid Herr
Clinical and mechanistic aspects of glucocorticoid-induced chemotherapy resistance in the majority of solid tumors.
Cancer biology & therapy 2007;6(2):278-87.
2007: Jiwu Wei; Gergely Jarmy; J Genuneit; Klaus-Michael Debatin; Christian Beltinger
Human blood late outgrowth endothelial cells for gene therapy of cancer: determinants of efficacy.
Gene therapy 2007;14(4):344-56.
2007: K La Ferla-Brühl; Mike-Andrew Westhoff; S Karl; Hubert Kasperczyk; Ralf Michael Zwacka; Klaus-Michael Debatin; Simone Fulda
NF-kappaB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition.
Oncogene 2007;26(4):571-82.
2007: Daniela Opel; Christopher Poremba; Thorsten Simon; Klaus-Michael Debatin; Simone Fulda
Activation of Akt predicts poor outcome in neuroblastoma.
Cancer research 2007;67(2):735-45.
2007: Meike Vogler; K Dürr; M Jovanovic; Klaus-Michael Debatin; Simone Fulda
Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells.
Oncogene 2007;26(2):248-57.
2007: M M Unger; J Wahl; Alexey Ushmorov; B Buechele; T Simmet; Klaus-Michael Debatin; Christian Beltinger
Enriching suicide gene bearing tumor cells for an increased bystander effect.
Cancer gene therapy 2007;14(1):30-8.
2006: Beate Karges; Rainer Muche; Ines Riegger; Martin Moritz; Eberhard Heinze; Klaus-Michael Debatin; Martin Wabitsch; Wolfram Karges
Injection of acidic or neutral insulin and pain: a single-center, prospective, controlled, noninterventional study in pediatric patients with type 1 diabetes mellitus.
Clinical therapeutics 2006;28(12):2094-101.
2006: Eva Pauly; Benedikt Fritzsching; Markus Dechant; Jörg Fellenberg; Christian Gerold Scheuerpflug; Klaus-Michael Debatin
Analysis of the CD95 ligand gene in 20 children with autoimmune lymphoproliferative syndrome (ALPS).
Blood 2006;108(10):3622-3; author reply 3623.
2006: Mehtap Kilic; Mehtap Kilic; Mike-Andrew Westhoff; Dirk Reinhardt; Simone Fulda; Klaus-Michael Debatin
Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin.
Blood 2006;108(10):3504-13.
2006: Chengwen Zhang; Benjamin Beckermann; Georgios Kallifatidis; Zheng Liu; Werner Rittgen; Lutz Edler; Peter Büchler; Klaus-Michael Debatin; Markus W Büchler; Helmut Friess; Ingrid Herr
Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma.
International journal of oncology 2006;29(5):1295-301.
2006: Simone Fulda; Christopher Poremba; Bernd Berwanger; Sabine Häcker; Martin Eilers; Holger Christiansen; Barbara Hero; Klaus-Michael Debatin
Loss of caspase-8 expression does not correlate with MYCN amplification, aggressive disease, or prognosis in neuroblastoma.
Cancer research 2006;66(20):10016-23.
2006: Chengwen Zhang; Armin Kolb; Jürgen Mattern; Nikolaus Gassler; Till Wenger; Kerstin Herzer; Klaus-Michael Debatin; Markus W Büchler; Helmut Friess; Werner Rittgen; Lutz Edler; Ingrid Herr
Dexamethasone desensitizes hepatocellular and colorectal tumours toward cytotoxic therapy.
Cancer letters 2006;242(1):104-11.
2006: Till Wenger; Jürgen Mattern; Roland Penzel; Nikolaus Gassler; Tobias L Haas; Martin Sprick; Henning Walczak; Peter H Krammer; Klaus-Michael Debatin; Ingrid Herr
Specific resistance upon lentiviral TRAIL transfer by intracellular retention of TRAIL receptors.
Cell death and differentiation 2006;13(10):1740-51.
2006: Klaus-Michael Debatin
CD95 system counter attack and prognostic impact.
Onkologie 2006;29(8-9):358-9.
2006: Simone Fulda; Klaus-Michael Debatin
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy.
Oncogene 2006;25(34):4798-811.
2006: Lüder Hinrich Meyer; Leonid Karawajew; Martin Schrappe; Wolf-Dieter Ludwig; Klaus-Michael Debatin; Karsten Stahnke
Cytochrome c-related caspase-3 activation determines treatment response and relapse in childhood precursor B-cell ALL.
Blood 2006;107(11):4524-31.
2006: Simone Fulda; Klaus-Michael Debatin
Modulation of apoptosis signaling for cancer therapy.
Archivum immunologiae et therapiae experimentalis 2006;54(3):173-5.
2006: Beate Karges; Ivana Durinovic-Belló; Eberhard Heinze; Klaus-Michael Debatin; Bernhard Boehm; Wolfram Karges
Immunological mechanisms associated with long-term remission of human type 1 diabetes.
Diabetes/metabolism research and reviews 2006;22(3):184-9.
2006: Carl Friedrich Classen; P I Bird; Klaus-Michael Debatin
Modulation of the granzyme B inhibitor proteinase inhibitor 9 (PI-9) by activation of lymphocytes and monocytes in vitro and by Epstein-Barr virus and bacterial infection.
Clinical and experimental immunology 2006;143(3):534-42.
2006: Hyun Soo Ko; Norbert Graf; Hans-Juergen Brambs; Klaus-Michael Debatin; Ivo Leuschner; Jochen Tröger; Jens-Peter Schenk
Clinical Quiz. A patient with hematuria and cystic renal mass.
Pediatric nephrology (Berlin, Germany) 2006;21(3):324-7.
2006: Pamela Fischer-Posovszky; Helge Hebestreit; Albert K Hofmann; Gudrun Strauss; Peter Möller; Klaus-Michael Debatin; Martin Wabitsch
Role of CD95-mediated adipocyte loss in autoimmune lipodystrophy.
The Journal of clinical endocrinology and metabolism 2006;91(3):1129-35.
2006: Chengwen Zhang; Alexander Marmé; Till Wenger; Paul Gutwein; Lutz Edler; Werner Rittgen; Klaus-Michael Debatin; Peter Altevogt; Jürgen Mattern; Ingrid Herr
Glucocorticoid-mediated inhibition of chemotherapy in ovarian carcinomas.
International journal of oncology 2006;28(2):551-8.
2006: Simone Fulda; Klaus-Michael Debatin
Targeting inhibitor of apoptosis proteins (IAPs) for diagnosis and treatment of human diseases.
Recent patents on anti-cancer drug discovery 2006;1(1):81-9.
2006: Simone Fulda; Klaus-Michael Debatin
Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review.
Cancer detection and prevention 2006;30(3):217-23.
2006: Chengwen Zhang; Armin Kolb; Peter Büchler; Andrew C B Cato; Jürgen Mattern; Werner Rittgen; Lutz Edler; Klaus-Michael Debatin; Markus W Büchler; Helmut Friess; Ingrid Herr
Corticosteroid co-treatment induces resistance to chemotherapy in surgical resections, xenografts and established cell lines of pancreatic cancer.
BMC cancer 2006;6():61.
2006: Chengwen Zhang; Jürgen Mattern; Axel Haferkamp; Jesco Pfitzenmaier; Markus Hohenfellner; Werner Rittgen; Lutz Edler; Klaus-Michael Debatin; E Groene; Ingrid Herr
Corticosteroid-induced chemotherapy resistance in urological cancers.
Cancer biology & therapy 2006;5(1):59-64.
2005: Stavros Giagkousiklidis; Meike Vogler; Mike-Andrew Westhoff; Hubert Kasperczyk; Klaus-Michael Debatin; Simone Fulda
Sensitization for gamma-irradiation-induced apoptosis by second mitochondria-derived activator of caspase.
Cancer research 2005;65(22):10502-13.
2005: Meike Vogler; Stavros Giagkousiklidis; Felicitas Genze; Juergen E Gschwend; Klaus-Michael Debatin; Simone Fulda
Inhibition of clonogenic tumor growth: a novel function of Smac contributing to its antitumor activity.
Oncogene 2005;24(48):7190-202.
2005: Carl Friedrich Classen; A Teigler-Schlegel; S Röttgers; Dirk Reinhardt; K Döhner; Klaus-Michael Debatin
AML bearing the translocation t(11;17)(q23;q21): involvement of MLL and a region close to RARA, with no differentiation response to retinoic acid.
Annals of hematology 2005;84(12):774-80.
2005: Hubert Kasperczyk; Katia La Ferla-Brühl; Mike-Andrew Westhoff; Lars Behrend; Ralf Michael Zwacka; Klaus-Michael Debatin; Simone Fulda
Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy.
Oncogene 2005;24(46):6945-56.
2005: S Grigem; Pamela Fischer-Posovszky; Klaus-Michael Debatin; E Loizon; Hubert Vidal; Martin Wabitsch
The effect of the HIV protease inhibitor ritonavir on proliferation, differentiation, lipogenesis, gene expression and apoptosis of human preadipocytes and adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2005;37(10):602-9.
2005: Simone Fulda; Klaus-Michael Debatin
HDAC inhibitors: double edge sword for TRAIL cancer therapy?
Cancer biology & therapy 2005;4(10):1113-5.
2005: Eva Baader; Agnieszka Toloczko; Uta Fuchs; Irene Schmid; Christian Beltinger; Harald Ehrhardt; Klaus-Michael Debatin; Irmela Jeremias
Tumor necrosis factor-related apoptosis-inducing ligand-mediated proliferation of tumor cells with receptor-proximal apoptosis defects.
Cancer research 2005;65(17):7888-95.
2005: Beate Karges; Gerd Krause; Janos Homoki; Klaus-Michael Debatin; Nicolas de Roux; Wolfram Karges
TSH receptor mutation V509A causes familial hyperthyroidism by release of interhelical constraints between transmembrane helices TMH3 and TMH5.
The Journal of endocrinology 2005;186(2):377-85.
2005: Irmela Jeremias; Karsten Stahnke; Klaus-Michael Debatin
CD95/Apo-1/Fas: independent cell death induced by doxorubicin in normal cultured cardiomyocytes.
Cancer immunology, immunotherapy : CII 2005;54(7):655-62.
2005: Carl Friedrich Classen; Wolfgang Behnisch; Dirk Reinhardt; Margit Koenig; Peter Möller; Klaus-Michael Debatin
Spontaneous complete and sustained remission of a rearrangement CBP (16p13)-positive disseminated congenital myelosarcoma.
Annals of hematology 2005;84(4):274-5.
2005: Andrea Mohr; Ralf Michael Zwacka; Gergely Jarmy; Chirlei Büneker; Hubert Schrezenmeier; Konstanze Döhner; Christian Beltinger; Markus Wiesneth; Klaus-Michael Debatin; Karsten Stahnke
Caspase-8L expression protects CD34+ hematopoietic progenitor cells and leukemic cells from CD95-mediated apoptosis.
Oncogene 2005;24(14):2421-9.
2005: Nikolaus Gassler; Chengwen Zhang; Till Wenger; Philipp A Schnabel; Hendrik Dienemann; Klaus-Michael Debatin; Jürgen Mattern; Ingrid Herr
Dexamethasone-induced cisplatin and gemcitabine resistance in lung carcinoma samples treated ex vivo.
British journal of cancer 2005;92(6):1084-8.
2005: Simone Fulda; Klaus-Michael Debatin
Resveratrol-mediated sensitisation to TRAIL-induced apoptosis depends on death receptor and mitochondrial signalling.
European journal of cancer (Oxford, England : 1990) 2005;41(5):786-98.
2005: Simone Fulda; Klaus-Michael Debatin
Sensitization for anticancer drug-induced apoptosis by betulinic Acid.
Neoplasia (New York, N.Y.) 2005;7(2):162-70.
2005: Alexey Ushmorov; Klaus-Michael Debatin; Christian Beltinger
Growth inhibition of murine neuroblastoma cells by c-myc with cell cycle arrest in G2/M.
Cancer biology & therapy 2005;4(2):181-6.
2005: Holger Cario; Klaus Schwarz; Norbert Jorch; Ulrike Kyank; Petro E Petrides; Dominik Schneider; Renate Uhle; Klaus-Michael Debatin; Elisabeth Kohne
Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis.
Haematologica 2005;90(1):19-24.
2004: Simone Fulda; Klaus-Michael Debatin
Exploiting death receptor signaling pathways for tumor therapy.
Biochimica et biophysica acta 2004;1705(1):27-41.
2004: Simone Fulda; Klaus-Michael Debatin
Apoptosis signaling in tumor therapy.
Annals of the New York Academy of Sciences 2004;1028():150-6.
2004: Simone Fulda; Klaus-Michael Debatin
Targeting apoptosis pathways in cancer therapy.
Current cancer drug targets 2004;4(7):569-76.
2004: Carl Friedrich Classen; Alexey Ushmorov; Phillip Bird; Klaus-Michael Debatin
The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias.
Haematologica 2004;89(11):1314-21.
2004: Simone Fulda; Irmela Jeremias; Klaus-Michael Debatin
Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells.
Oncogene 2004;23(46):7611-20.
2004: A Mohr; Ralf Michael Zwacka; Klaus-Michael Debatin; Karsten Stahnke
A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release.
Cell death and differentiation 2004;11(10):1153-4.
2004: Simone Fulda; Klaus-Michael Debatin
Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol.
Oncogene 2004;23(40):6702-11.
2004: Simone Fulda; Klaus-Michael Debatin
Signaling through death receptors in cancer therapy.
Current opinion in pharmacology 2004;4(4):327-32.
2004: Harald Ehrhardt; Simone Fulda; M Führer; Klaus-Michael Debatin; Irmela Jeremias
Betulinic acid-induced apoptosis in leukemia cells.
Leukemia 2004;18(8):1406-12.
2004: Irmela Jeremias; H H Steiner; A Benner; Klaus-Michael Debatin; Christel Herold-Mende
Cell death induction by betulinic acid, ceramide and TRAIL in primary glioblastoma multiforme cells.
Acta neurochirurgica 2004;146(7):721-9.
2004: Karsten Stahnke; A Mohr; J Liu; Lüder Hinrich Meyer; Leonid Karawajew; Klaus-Michael Debatin
Identification of deficient mitochondrial signaling in apoptosis resistant leukemia cells by flow cytometric analysis of intracellular cytochrome c, caspase-3 and apoptosis.
Apoptosis : an international journal on programmed cell death 2004;9(4):457-65.
2004: C Friesen; Y Kiess; Klaus-Michael Debatin
A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells.
Cell death and differentiation 2004;11 Suppl 1():S73-85.
2004: Holger Cario; Klaus Schwarz; Klaus-Michael Debatin; Elisabeth Kohne
Congenital erythrocytosis and polycythemia vera in childhood and adolescence.
Klinische Pädiatrie 2004;216(3):157-62.
2004: Jiwu Wei; Sabine Blum; Marcus Unger; Gergely Jarmy; Mathias Lamparter; Albert Geishauser; Georgios A Vlastos; Gordon Chan; Klaus-Dieter Fischer; Dirk Rattat; Klaus-Michael Debatin; Antonis K Hatzopoulos; Christian Beltinger
Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery.
Cancer cell 2004;5(5):477-88.
2004: Beate Karges; Ivana Durinovic-Belló; Eberhard Heinze; Bernhard O Boehm; Klaus-Michael Debatin; Wolfram Karges
Complete long-term recovery of beta-cell function in autoimmune type 1 diabetes after insulin treatment.
Diabetes care 2004;27(5):1207-8.
2004: Markus J Dechant; Jörg Fellenberg; Christian Gerold Scheuerpflug; Volker Ewerbeck; Klaus-Michael Debatin
Mutation analysis of the apoptotic "death-receptors" and the adaptors TRADD and FADD/MORT-1 in osteosarcoma tumor samples and osteosarcoma cell lines.
International journal of cancer. Journal international du cancer 2004;109(5):661-7.
2004: Klaus-Michael Debatin; Peter H Krammer
Death receptors in chemotherapy and cancer.
Oncogene 2004;23(16):2950-66.
2004: Pamela Fischer-Posovszky; Hans Tornqvist; Klaus-Michael Debatin; Martin Wabitsch
Inhibition of death-receptor mediated apoptosis in human adipocytes by the insulin-like growth factor I (IGF-I)/IGF-I receptor autocrine circuit.
Endocrinology 2004;145(4):1849-59.
2004: Klaus-Michael Debatin
Apoptosis pathways in cancer and cancer therapy.
Cancer immunology, immunotherapy : CII 2004;53(3):153-9.
2004: Stella Okouoyo; Kerstin Herzer; Esat Ucur; Jürgen Mattern; Peter H Krammer; Klaus-Michael Debatin; Ingrid Herr
Rescue of death receptor and mitochondrial apoptosis signaling in resistant human NSCLC in vivo.
International journal of cancer. Journal international du cancer 2004;108(4):580-7.
2004: Martin Wabitsch; H Hauner; M Hertrampf; Rainer Muche; B Hay; H Mayer; Wolfgang Kratzer; Klaus-Michael Debatin; Eberhard Heinze
Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(2):307-13.
2004: Beate Karges; Bruno Leheup; Eugen J Schoenle; Cintia Castro-Correia; Manuel Fontoura; Roland Pfäffle; Werner Andler; Klaus-Michael Debatin; Wolfram Karges
Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe.
Hormone research 2004;62(3):149-55.
2004: Simone Fulda; Klaus-Michael Debatin
Modulation of TRAIL signaling for cancer therapy.
Vitamins and hormones 2004;67():275-90.
2004: Simone Fulda; Klaus-Michael Debatin
Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol.
Cancer research 2004;64(1):337-46.
2003: Frans van Valen; Simone Fulda; Karl-Ludwig Schäfer; Borna Truckenbrod; Marc Hotfilder; Christopher Poremba; Klaus-Michael Debatin; Winfried Winkelmann
Selective and nonselective toxicity of TRAIL/Apo2L combined with chemotherapy in human bone tumour cells vs. normal human cells.
International journal of cancer. Journal international du cancer 2003;107(6):929-40.
2003: Christian Denzer; Rainer Muche; Hermann Mayer; Eberhard Heinze; Klaus-Michael Debatin; Martin Wabitsch
Serum uric acid levels in obese children and adolescents: linkage to testosterone levels and pre-metabolic syndrome.
Journal of pediatric endocrinology & metabolism : JPEM 2003;16(9):1225-32.
2003: Esat Ucur; Jürgen Mattern; Till Wenger; Stella Okouoyo; A Schroth; Klaus-Michael Debatin; Ingrid Herr
Induction of apoptosis in experimental human B cell lymphomas by conditional TRAIL-expressing T cells.
British journal of cancer 2003;89(11):2155-62.
2003: Olaf Sommerburg; Claus-Dieter Langhans; Jürgen Arnhold; Michael Leichsenring; Costantino Salerno; Carlo Crifò; Georg F Hoffmann; Klaus-Michael Debatin; Werner G Siems
Beta-carotene cleavage products after oxidation mediated by hypochlorous acid--a model for neutrophil-derived degradation.
Free radical biology & medicine 2003;35(11):1480-90.
2003: Dominik Krilleke; Esat Ucur; Dianne Pulte; Klaus Schulze-Osthoff; Klaus-Michael Debatin; Ingrid Herr
Inhibition of JNK signaling diminishes early but not late cellular stress-induced apoptosis.
International journal of cancer. Journal international du cancer 2003;107(4):520-7.
2003: Karsten Stahnke; S Eckhoff; A Mohr; Lüder Hinrich Meyer; Klaus-Michael Debatin
Apoptosis induction in peripheral leukemia cells by remission induction treatment in vivo: selective depletion and apoptosis in a CD34+ subpopulation of leukemia cells.
Leukemia 2003;17(11):2130-9.
2003: Holger Cario; Heike L Pahl; Klaus Schwarz; Christoph Galm; Martin Hoffmann; Martin Burdelski; Elisabeth Kohne; Klaus-Michael Debatin
Familial polycythemia vera with Budd-Chiari syndrome in childhood.
British journal of haematology 2003;123(2):346-52.
2003: Carl Friedrich Classen; Klaus-Michael Debatin; Wilhelm Friedrich; Ansgar S Schulz
Long-term remission of APL with a second allogeneic BMT after CNS relapse following HLA-identical allogeneic BMT.
Bone marrow transplantation 2003;32(8):843-6.
2003: Claudia Friesen; Annelie Lubatschofski; Jörg Kotzerke; Inga Buchmann; Sven N Reske; Klaus-Michael Debatin
Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cells.
European journal of nuclear medicine and molecular imaging 2003;30(9):1251-61.
2003: Carl Friedrich Classen; A Gnekow; Klaus-Michael Debatin
Terminal differentiation in vitro of patient-derived post-TMD megakaryoblastic AML cells.
Annals of hematology 2003;82(8):506-10.
2003: Gudrun Strauss; Ingrid Knape; Ingo Melzner; Klaus-Michael Debatin
Constitutive caspase activation and impaired death-inducing signaling complex formation in CD95-resistant, long-term activated, antigen-specific T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1172-82.
2003: Simone Fulda; Klaus-Michael Debatin
Apoptosis pathways in neuroblastoma therapy.
Cancer letters 2003;197(1-2):131-5.
2003: Simone Fulda; Klaus-Michael Debatin
Death receptor signaling in cancer therapy.
Current medicinal chemistry. Anti-cancer agents 2003;3(4):253-62.
2003: Harald Ehrhardt; Simone Fulda; Irene Schmid; John Hiscott; Klaus-Michael Debatin; Irmela Jeremias
TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.
Oncogene 2003;22(25):3842-52.
2003: Ingrid Herr; Esat Ucur; Kerstin Herzer; Stella Okouoyo; Rüdiger Ridder; Peter H Krammer; Magnus von Knebel Doeberitz; Klaus-Michael Debatin
Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas.
Cancer research 2003;63(12):3112-20.
2003: Juliane Eggermann; Stefanie Kliche; Gergely Jarmy; Karin Hoffmann; Ulrike Mayr-Beyrle; Klaus-Michael Debatin; Johannes Waltenberger; Christian Beltinger
Endothelial progenitor cell culture and differentiation in vitro: a methodological comparison using human umbilical cord blood.
Cardiovascular research 2003;58(2):478-86.
2003: Carl Friedrich Classen; Christine S Falk; Claudia Friesen; Simone Fulda; Ingrid Herr; Klaus-Michael Debatin
Natural killer resistance of a drug-resistant leukemia cell line, mediated by up-regulation of HLA class I expression.
Haematologica 2003;88(5):509-21.
2003: Klaus-Michael Debatin; Karsten Stahnke; Simone Fulda
Apoptosis in hematological disorders.
Seminars in cancer biology 2003;13(2):149-58.
2003: Klaus-Michael Debatin
Role of apoptosis in congenital hematologic disorders and bone marrow failure.
Reviews in clinical and experimental hematology 2003;7(1):57-71.
2003: Holger Cario; Reinhard W Holl; Klaus-Michael Debatin; Elisabeth Kohne
Insulin sensitivity and beta-cell secretion in thalassaemia major with secondary haemochromatosis: assessment by oral glucose tolerance test.
European journal of pediatrics 2003;162(3):139-46.
2003: Simone Fulda; Klaus-Michael Debatin
Apoptosis pathways: turned on their heads?
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2003;6(1):1-3.
2003: Holger Cario; Reinhard W Holl; Klaus-Michael Debatin; Elisabeth Kohne
Disproportionately elevated fasting proinsulin levels in normoglycemic patients with thalassemia major are correlated to the degree of iron overload.
Hormone research 2003;59(2):73-8.
2002: Klaus-Michael Debatin; Delphine Poncet; Guido Kroemer
Chemotherapy: targeting the mitochondrial cell death pathway.
Oncogene 2002;21(57):8786-803.
2002: Ursula Reuter; Joachim Roesler; Christian Thiede; Ansgar Schulz; Carl Friedrich Classen; Uta Oelschlagel; Klaus-Michael Debatin; Wilhelm Friedrich
Correction of complete interferon-gamma receptor 1 deficiency by bone marrow transplantation.
Blood 2002;100(12):4234-5.
2002: Bernd Baumann; Frank Bohnenstengel; Daniela Siegmund; Harald Wajant; Christoph Weber; Ingrid Herr; Klaus-Michael Debatin; Peter Proksch; Thomas Wirth
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells.
The Journal of biological chemistry 2002;277(47):44791-800.
2002: Susanne Liptay; Simone Fulda; Marta Schanbacher; Soizic Bourteele; Karine F Ferri; Guido Kroemer; Guido Adler; Klaus-Michael Debatin; Roland M Schmid
Molecular mechanisms of sulfasalazine-induced T-cell apoptosis.
British journal of pharmacology 2002;137(5):608-20.
2002: Holger Cario; M Wegener; Klaus-Michael Debatin; Elisabeth Kohne
Treatment with hydroxyurea in thalassemia intermedia with paravertebral pseudotumors of extramedullary hematopoiesis.
Annals of hematology 2002;81(8):478-82.
2002: Simone Fulda; Wolfgang Wick; Michael Weller; Klaus-Michael Debatin
Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.
Nature medicine 2002;8(8):808-15.
2002: Pamela Fischer-Posovszky; Klaus-Michael Debatin; Martin Wabitsch
[Lipodystrophies].
Klinische Pädiatrie 2002;214(3):99-103.
2002: Pamela Fischer; Peter Möller; Lutz Bindl; Ingo Melzner; Hans Tornqvist; Klaus-Michael Debatin; Martin Wabitsch
Induction of adipocyte differentiation by a thiazolidinedione in cultured, subepidermal, fibroblast-like cells of an infant with congenital generalized lipodystrophy.
The Journal of clinical endocrinology and metabolism 2002;87(5):2384-90.
2002: G Strauss; W Osen; Klaus-Michael Debatin
Induction of apoptosis and modulation of activation and effector function in T cells by immunosuppressive drugs.
Clinical and experimental immunology 2002;128(2):255-66.
2002: Ansgar S Schulz; Carl Friedrich Classen; Walter A Mihatsch; Michael Sigl-Kraetzig; Markus Wiesneth; Klaus-Michael Debatin; Wilhelm Friedrich; Susanna M Müller
HLA-haploidentical blood progenitor cell transplantation in osteopetrosis.
Blood 2002;99(9):3458-60.
2002: Simone Fulda; Klaus-Michael Debatin
IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway.
Oncogene 2002;21(15):2295-308.
2002: Simone Fulda; Eric Meyer; Klaus-Michael Debatin
Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression.
Oncogene 2002;21(15):2283-94.
2002: Christian Beltinger; Simone Fulda; Henning Walczak; Klaus-Michael Debatin
TRAIL enhances thymidine kinase/ganciclovir gene therapy of neuroblastoma cells.
Cancer gene therapy 2002;9(4):372-81.
2001: Karsten Stahnke; Simone Fulda; C Friesen; G Strauss; Klaus-Michael Debatin
Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy.
Blood 2001;98(10):3066-73.
2001: M Ege; Burkhard J Manfras; Gotthold Barbi; Ansgar S Schulz; Michael Sigl-Kraetzig; Klaus-Michael Debatin; Wilhelm Friedrich; S M Mueller
Eradication of a dysfunctional HLA-haploidentical T cell system by a second HLA-identical BMT.
Bone marrow transplantation 2001;28(10):993-5.
2001: Ingrid Herr; Klaus-Michael Debatin
Cellular stress response and apoptosis in cancer therapy.
Blood 2001;98(9):2603-14.
2001: Simone Fulda; M U Küfer; Eric Meyer; Frans van Valen; Barbara Dockhorn-Dworniczak; Klaus-Michael Debatin
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer.
Oncogene 2001;20(41):5865-77.
2001: C F Classen; Ansgar S Schulz; Klaus-Michael Debatin; Wilhelm Friedrich
Severe persistent neuropsychiatric toxicity after a human leucocyte antigen-non-identical peripheral blood stem cell transplantation (total body irradiation, etoposide, thiotepa) and interleukin 2-based experimental therapy for poor prognosis relapse acute lymphoblastic leukaemia.
British journal of haematology 2001;114(2):487-9.
2001: Carl Friedrich Classen; Ansgar S Schulz; Michael Sigl-Kraetzig; G F Hoffmann; H Anne Simmonds; Lynette Fairbanks; Klaus-Michael Debatin; Wilhelm Friedrich
Successful HLA-identical bone marrow transplantation in a patient with PNP deficiency using busulfan and fludarabine for conditioning.
Bone marrow transplantation 2001;28(1):93-6.
2001: Wolfgang Lindner; W Behnisch; Ulrich Kunz; Klaus-Michael Debatin; Frank Pohlandt
Congenital neuroblastoma mimicking early onset sepsis.
European journal of pediatrics 2001;160(7):436-8.
2001: Christian Beltinger; Klaus-Michael Debatin
Murine models for experimental therapy of pediatric solid tumors with poor prognosis.
International journal of cancer. Journal international du cancer 2001;92(3):313-8.
2001: Simone Fulda; Eric Meyer; C Friesen; S A Susin; G Kroemer; Klaus-Michael Debatin
Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis.
Oncogene 2001;20(9):1063-75.
2001: Klaus-Michael Debatin
Cell death in T- and B-cell development.
Annals of hematology 2001;80 Suppl 3():B29-31.
2001: C G Scheuerpflug; Peter Lichter; Klaus-Michael Debatin; Antoaneta Mincheva
Assignment of TRADD to human chromosome band 16q22 by in situ hybridization.
Cytogenetics and cell genetics 2001;92(3-4):347-8.
2001: Martin Wabitsch; Rolf E Brenner; Ingo Melzner; M Braun; Peter Möller; Eberhard Heinze; Klaus-Michael Debatin; H Hauner
Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(1):8-15.
2001: T Böhler; Uwe Wintergerst; Richard Linde; B H Belohradsky; Klaus-Michael Debatin
CD95 (APO-1/Fas) expression on naive CD4(+) T cells increases with disease progression in HIV-infected children and adolescents: effect of highly active antiretroviral therapy (HAART).
Pediatric research 2001;49(1):101-10.
2000: Susanna M Müller; T Kohn; Ansgar S Schulz; Klaus-Michael Debatin; Wilhelm Friedrich
Similar pattern of thymic-dependent T-cell reconstitution in infants with severe combined immunodeficiency after human leukocyte antigen (HLA)-identical and HLA-nonidentical stem cell transplantation.
Blood 2000;96(13):4344-9.
2000: Simone Fulda; Klaus-Michael Debatin
Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors.
Medical and pediatric oncology 2000;35(6):616-8.
2000: Simone Fulda; W Lutz; M Schwab; Klaus-Michael Debatin
MycN sensitizes neuroblastoma cells for drug-triggered apoptosis.
Medical and pediatric oncology 2000;35(6):582-4.
2000: Martin Wabitsch; Eberhard Heinze; Klaus-Michael Debatin; Werner F Blum
IGF-I- and IGFBP-3-expression in cultured human preadipocytes and adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2000;32(11-12):555-9.
2000: Frans van Valen; Simone Fulda; Borna Truckenbrod; Vera Eckervogt; Jürgen Sonnemann; Axel Hillmann; Robert Rödl; Christiane Hoffmann; Winfried Winkelmann; L Schäfer; Barbara Dockhorn-Dworniczak; T Wessel; Joachim Boos; Klaus-Michael Debatin; Heribert Jürgens
Apoptotic responsiveness of the Ewing's sarcoma family of tumours to tumour necrosis factor-related apoptosis-inducing ligand (TRAIL).
International journal of cancer. Journal international du cancer 2000;88(2):252-9.
2000: Ingrid Herr; Dominik Krilleke; Klaus-Michael Debatin
A sensitive, non-radioactive and fast method for detection of JNK/SAPK activity in leukemic T cells.
Leukemia 2000;14(10):1859-60.
2000: Ingrid Herr; C Posovszky; Luisa Di Marzio; M G Cifone; T Boehler; Klaus-Michael Debatin
Autoamplification of apoptosis following ligation of CD95-L, TRAIL and TNF-alpha.
Oncogene 2000;19(37):4255-62.
2000: Irmela Jeremias; Christian Kupatt; Ana Martin Villalba; Helmut Habazettl; Johannes Schenkel; Peter Boekstegers; Klaus-Michael Debatin
Involvement of CD95/Apo1/Fas in cell death after myocardial ischemia.
Circulation 2000;102(8):915-20.
2000: Simone Fulda; E Meyer; Klaus-Michael Debatin
Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression.
Cancer research 2000;60(14):3947-56.
2000: Christian Beltinger; Simone Fulda; Thomas Kammertoens; Wolfgang Uckert; Klaus-Michael Debatin
Mitochondrial amplification of death signals determines thymidine kinase/ganciclovir-triggered activation of apoptosis.
Cancer research 2000;60(12):3212-7.
2000: Consolato Sergi; T Böhler; Günther Schönrich; H Sieverts; SU Roth; Klaus-Michael Debatin; Herwart F Otto
Occult thyroid pathology in a child with acquired immunodeficiency syndrome. Case report and review of the drug-related pathology in pediatric acquired immunodeficiency syndrome.
Pathology oncology research : POR 2000;6(3):227-32.
2000: Jörg Fellenberg; Hans Mau; S Nedel; Volker Ewerbeck; Klaus-Michael Debatin
Drug-induced apoptosis in osteosarcoma cell lines is mediated by caspase activation independent of CD95-receptor/ligand interaction.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(1):10-7.
2000: Andrea Kolbus; Ingrid Herr; M Schreiber; Klaus-Michael Debatin; Erwin F Wagner; Peter Angel
c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents.
Molecular and cellular biology 2000;20(2):575-82.
2000: Simone Fulda; G Strauss; E Meyer; Klaus-Michael Debatin
Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells.
Blood 2000;95(1):301-8.
1999: Susanne Liptay; Max G Bachem; G Häcker; Guido Adler; Klaus-Michael Debatin; Roland M Schmid
Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine.
British journal of pharmacology 1999;128(7):1361-9.
1999: C Friesen; Simone Fulda; Klaus-Michael Debatin
Cytotoxic drugs and the CD95 pathway.
Leukemia 1999;13(11):1854-8.
1999: T Böhler; Klaus-Michael Debatin; Richard Linde
Sensitivity of CD4+ peripheral blood T cells toward spontaneous and CD95 (APO-1/Fas)-induced apoptosis in pediatric human immunodeficiency virus infection.
Blood 1999;94(5):1829-33.
1999: S Müller; A Schulz; U Reiss; K Schwarz; T Schreiner; Markus Wiesneth; Klaus-Michael Debatin; Wilhelm Friedrich
Definition of a critical T cell threshold for prevention of GVHD after HLA non-identical PBPC transplantation in children.
Bone marrow transplantation 1999;24(6):575-81.
1999: T Böhler; J. WALCHER; G Hölzl-Wenig; P Schnitzler; M Geiss; B Buchholz; Richard Linde; H Rütschle; Klaus-Michael Debatin
Expression of CD69 on T-cells from HIV-1-infected children and adolescents increases with increasing viral load.
European journal of pediatrics 1999;158(8):638-44.
1999: Simone Fulda; Irmela Jeremias; H H Steiner; T Pietsch; Klaus-Michael Debatin
Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells.
International journal of cancer. Journal international du cancer 1999;82(3):435-41.
1999: Christian Beltinger; Simone Fulda; Thomas Kammertoens; E Meyer; Wolfgang Uckert; Klaus-Michael Debatin
Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8699-704.
1999: Simone Fulda; Irmela Jeremias; T Pietsch; Klaus-Michael Debatin
Betulinic acid: a new chemotherapeutic agent in the treatment of neuroectodermal tumors.
Klinische Pädiatrie 1999;211(4):319-22.
1999: Francesca Bernassola; Christian Gerold Scheuerpflug; Ingrid Herr; P H Krammer; Klaus-Michael Debatin; Gerry Melino
Induction of apoptosis by IFNgamma in human neuroblastoma cell lines through the CD95/CD95L autocrine circuit.
Cell death and differentiation 1999;6(7):652-60.
1999: Ana Martin Villalba; Ingrid Herr; Irmela Jeremias; M Hahne; Roland Brandt; Johannes Vogel; Johannes Schenkel; Thomas Herdegen; Klaus-Michael Debatin
CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(10):3809-17.
1999: T Böhler; J. WALCHER; G Hölzl-Wenig; M Geiss; B Buchholz; Richard Linde; Klaus-Michael Debatin
Early effects of antiretroviral combination therapy on activation, apoptosis and regeneration of T cells in HIV-1-infected children and adolescents.
AIDS (London, England) 1999;13(7):779-89.
1999: C Friesen; Simone Fulda; Klaus-Michael Debatin
Induction of CD95 ligand and apoptosis by doxorubicin is modulated by the redox state in chemosensitive- and drug-resistant tumor cells.
Cell death and differentiation 1999;6(5):471-80.
1999: Ingrid Herr; Ana Martin Villalba; E Kurz; P Roncaioli; Johannes Schenkel; M G Cifone; Klaus-Michael Debatin
FK506 prevents stroke-induced generation of ceramide and apoptosis signaling.
Brain research 1999;826(2):210-9.
1999: Carl Friedrich Classen; S Fulda; C Friesen; Klaus-Michael Debatin
Decreased sensitivity of drug-resistant cells towards T cell cytotoxicity.
Leukemia 1999;13(3):410-8.
1999: C Posovszky; C Friesen; Ingrid Herr; Klaus-Michael Debatin
Chemotherapeutic drugs sensitize pre-B ALL cells for CD95- and cytotoxic T-lymphocyte-mediated apoptosis.
Leukemia 1999;13(3):400-9.
1999: Simone Fulda; W Lutz; M Schwab; Klaus-Michael Debatin
MycN sensitizes neuroblastoma cells for drug-induced apoptosis.
Oncogene 1999;18(7):1479-86.
1999: Ingrid Herr; Dagmar Wilhelm; E Meyer; Irmela Jeremias; Peter Angel; Klaus-Michael Debatin
JNK/SAPK activity contributes to TRAIL-induced apoptosis.
Cell death and differentiation 1999;6(2):130-5.
1999: Ingrid Herr; Dagmar Wilhelm; T Böhler; Peter Angel; Klaus-Michael Debatin
JNK/SAPK activity is not sufficient for anticancer therapy-induced apoptosis involving CD95-L, TRAIL and TNF-alpha.
International journal of cancer. Journal international du cancer 1999;80(3):417-24.
1999: Reinhard W Holl; P Bucher; Wolfgang Sorgo; Eberhard Heinze; Janos Homoki; Klaus-Michael Debatin
Suppression of growth hormone by oral glucose in the evaluation of tall stature.
Hormone research 1999;51(1):20-4.
1998: Simone Fulda; C Scaffidi; S A Susin; Peter H Krammer; G Kroemer; Marcus E Peter; Klaus-Michael Debatin
Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid.
The Journal of biological chemistry 1998;273(51):33942-8.
1998: Irmela Jeremias; Klaus-Michael Debatin
TRAIL induces apoptosis and activation of NFkappaB.
European cytokine network 1998;9(4):687-8.
1998: Reinhard W Holl; Matthias Grabert; Eberhard Heinze; Wolfgang Sorgo; Klaus-Michael Debatin
Age at onset and long-term metabolic control affect height in type-1 diabetes mellitus.
European journal of pediatrics 1998;157(12):972-7.
1998: Simone Fulda; C Scaffidi; T Pietsch; Peter H Krammer; Marcus E Peter; Klaus-Michael Debatin
Activation of the CD95 (APO-1/Fas) pathway in drug- and gamma-irradiation-induced apoptosis of brain tumor cells.
Cell death and differentiation 1998;5(10):884-93.
1998: Simone Fulda; S A Susin; G Kroemer; Klaus-Michael Debatin
Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells.
Cancer research 1998;58(19):4453-60.
1998: Christian Beltinger; T Böhler; L Karawajew; WD Ludwig; M Schrappe; Klaus-Michael Debatin
Mutation analysis of CD95 (APO-1/Fas) in childhood B-lineage acute lymphoblastic leukaemia.
British journal of haematology 1998;102(3):722-8.
1998: Karsten Stahnke; S Hecker; Elisabeth Kohne; Klaus-Michael Debatin
CD95 (APO-1/FAS)-mediated apoptosis in cytokine-activated hematopoietic cells.
Experimental hematology 1998;26(9):844-50.
1998: Werner Lutz; Simone Fulda; Irmela Jeremias; Klaus-Michael Debatin; Manfred Schwab
MycN and IFNgamma cooperate in apoptosis of human neuroblastoma cells.
Oncogene 1998;17(3):339-46.
1998: Christian Beltinger; T Böhler; M Schrappe; WD Ludwig; Klaus-Michael Debatin
[The role of CD95 (APO-1/Fas) mutations in lymphoproliferative and malignant lymphatic diseases].
Klinische Pädiatrie 1998;210(4):153-8.
1998: Simone Fulda; C Friesen; Klaus-Michael Debatin
Molecular determinants of apoptosis induced by cytotoxic drugs.
Klinische Pädiatrie 1998;210(4):148-52.
1998: Irmela Jeremias; Christian Kupatt; B Baumann; Ingrid Herr; T Wirth; Klaus-Michael Debatin
Inhibition of nuclear factor kappaB activation attenuates apoptosis resistance in lymphoid cells.
Blood 1998;91(12):4624-31.
1998: Christian Beltinger; E Kurz; T Böhler; M Schrappe; WD Ludwig; Klaus-Michael Debatin
CD95 (APO-1/Fas) mutations in childhood T-lineage acute lymphoblastic leukemia.
Blood 1998;91(10):3943-51.
1998: Reinhard W Holl; Matthias Grabert; Wolfgang Sorgo; Eberhard Heinze; Klaus-Michael Debatin
Contributions of age, gender and insulin administration to weight gain in subjects with IDDM.
Diabetologia 1998;41(5):542-7.
1998: Reinhard W Holl; G E Lang; Matthias Grabert; Eberhard Heinze; G K Lang; Klaus-Michael Debatin
Diabetic retinopathy in pediatric patients with type-1 diabetes: effect of diabetes duration, prepubertal and pubertal onset of diabetes, and metabolic control.
The Journal of pediatrics 1998;132(5):790-4.
1998: Reinhard W Holl; Matthias Grabert; Eberhard Heinze; Klaus-Michael Debatin
Objective assessment of smoking habits by urinary cotinine measurement in adolescents and young adults with type 1 diabetes. Reliability of reported cigarette consumption and relationship to urinary albumin excretion.
Diabetes care 1998;21(5):787-91.
1998: Reinhard W Holl; C Buck; Holger Cario; A Wolf; Angelika Thon; Elisabeth Kohne; Klaus-Michael Debatin
Diagnosis of diabetes in cystic fibrosis and thalassemia major.
Diabetes care 1998;21(4):671-2.
1998: Simone Fulda; Marek Los; C Friesen; Klaus-Michael Debatin
Chemosensitivity of solid tumor cells in vitro is related to activation of the CD95 system.
International journal of cancer. Journal international du cancer 1998;76(1):105-14.
1998: C Scaffidi; Simone Fulda; A Srinivasan; C Friesen; F Li; K J Tomaselli; Klaus-Michael Debatin; Peter H Krammer; Marcus E Peter
Two CD95 (APO-1/Fas) signaling pathways.
The EMBO journal 1998;17(6):1675-87.
1998: K Stricker; E Knipping; T Böhler; A Benner; Peter H Krammer; Klaus-Michael Debatin
Anti-CD95 (APO-1/Fas) autoantibodies and T cell depletion in human immunodeficiency virus type 1 (HIV-1)-infected children.
Cell death and differentiation 1998;5(3):222-30.
1998: Klaus-Michael Debatin
CD95 (APO-1/Fas) in hematopoietic diseases.
Results and problems in cell differentiation 1998;24():157-74.
1998: Irmela Jeremias; Ingrid Herr; T Boehler; Klaus-Michael Debatin
TRAIL/Apo-2-ligand-induced apoptosis in human T cells.
European journal of immunology 1998;28(1):143-52.
1997: C Friesen; Simone Fulda; Klaus-Michael Debatin
Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells.
Leukemia 1997;11(11):1833-41.
1997: Simone Fulda; C Friesen; Marek Los; C Scaffidi; W Mier; M Benedict; Gabriel Nuñez; Peter H Krammer; Marcus E Peter; Klaus-Michael Debatin
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.
Cancer research 1997;57(21):4956-64.
1997: Marek Los; Ingrid Herr; C Friesen; Simone Fulda; K Schulze-Osthoff; Klaus-Michael Debatin
Cross-resistance of CD95- and drug-induced apoptosis as a consequence of deficient activation of caspases (ICE/Ced-3 proteases).
Blood 1997;90(8):3118-29.
1997: Ingrid Herr; Dagmar Wilhelm; T Böhler; Peter Angel; Klaus-Michael Debatin
Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis.
The EMBO journal 1997;16(20):6200-8.
1997: Simone Fulda; H Sieverts; C Friesen; Ingrid Herr; Klaus-Michael Debatin
The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells.
Cancer research 1997;57(17):3823-9.
1997: T Böhler; C Bäumler; Ingrid Herr; Andreas H Groll; M Kurz; Klaus-Michael Debatin
Activation of the CD95 system increases with disease progression in human immunodeficiency virus type 1-infected children and adolescents.
The Pediatric infectious disease journal 1997;16(8):754-9.
1997: Jörg Fellenberg; Hans Mau; Christian Gerold Scheuerpflug; Volker Ewerbeck; Klaus-Michael Debatin
Modulation of resistance to anti-APO-1-induced apoptosis in osteosarcoma cells by cytokines.
International journal of cancer. Journal international du cancer 1997;72(3):536-42.
1997: T Böhler; I Herr; Klaus-Michael Debatin; M Geiss; J Haas
Downregulation of increased CD95 (APO-1/Fas) ligand in T cells from human immunodeficiency virus-type 1-infected children after antiretroviral therapy.
Blood 1997;90(2):886-8.
1997: T Böhler; S Nedel; Klaus-Michael Debatin
CD95-induced apoptosis contributes to loss of primed/memory but not resting/naive T cells in children infected with human immunodeficiency virus type 1.
Pediatric research 1997;41(6):878-85.
1997: Klaus-Michael Debatin; Christian Beltinger; T Böhler; Jörg Fellenberg; C Friesen; Simone Fulda; Ingrid Herr; M Los; Christian Gerold Scheuerpflug; H Sieverts; Karsten Stahnke
Regulation of apoptosis through CD95 (APO-I/Fas) receptor-ligand interaction.
Biochemical Society transactions 1997;25(2):405-10.
1997: Marcus E Peter; FC Kischkel; C G Scheuerpflug; JP Medema; Klaus-Michael Debatin; Peter H Krammer
Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex.
European journal of immunology 1997;27(5):1207-12.
1996: M Csóka; Gudrun Strauss; Klaus-Michael Debatin; Gerhard Moldenhauer
Activation of T cell cytotoxicity against autologous common acute lymphoblastic leukemia (cALL) blasts by CD3xCD19 bispecific antibody.
Leukemia 1996;10(11):1765-72.
1996: C B Bäumler; T Böhler; Ingrid Herr; Axel Benner; Peter H Krammer; Klaus-Michael Debatin
Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children.
Blood 1996;88(5):1741-6.
1996: A Ehret; M O Westendorp; Ingrid Herr; Klaus-Michael Debatin; Jonathan Luke Heeney; R Frank; Peter H Krammer
Resistance of chimpanzee T cells to human immunodeficiency virus type 1 Tat-enhanced oxidative stress and apoptosis.
Journal of virology 1996;70(9):6502-7.
1996: Ingrid Herr; L Balemans; T Böhler; Henning Walczak; Klaus-Michael Debatin
Monitoring of CD95 (APO-1/Fas) ligand expression in human T cells by quantitative RT-PCR.
Cell death and differentiation 1996;3(3):299-305.
1996: C Friesen; Ingrid Herr; Peter H Krammer; Klaus-Michael Debatin
Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells.
Nature medicine 1996;2(5):574-7.
1996: Klaus-Michael Debatin
Disturbances of the CD95 (APO-1/Fas) system in disorders of lymphohaematopoietic cells.
Cell death and differentiation 1996;3(2):185-9.
1995: M O Westendorp; R Frank; C Ochsenbauer; K Stricker; J Dhein; Henning Walczak; Klaus-Michael Debatin; Peter H Krammer
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.
Nature 1995;375(6531):497-500.
1995: J Dhein; Henning Walczak; M O Westendorp; C Bäumler; K Stricker; R Frank; Klaus-Michael Debatin; Peter H Krammer
Molecular mechanisms of APO-1/Fas(CD95)-mediated apoptosis in tolerance and AIDS.
Behring Institute Mitteilungen 1995;(96):13-20.
1995: Klaus-Michael Debatin; P H Krammer
Resistance to APO-1 (CD95) induced apoptosis in T-ALL is determined by a BCL-2 independent anti-apoptotic program.
Leukemia 1995;9(5):815-20.
1995: E Knipping; Klaus-Michael Debatin; K Stricker; B Heilig; A Eder; Peter H Krammer
Identification of soluble APO-1 in supernatants of human B- and T-cell lines and increased serum levels in B- and T-cell leukemias.
Blood 1995;85(6):1562-9.
1995: J Dhein; Henning Walczak; C Bäumler; Klaus-Michael Debatin; Peter H Krammer
Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
Nature 1995;373(6513):438-41.
1994: K M Lücking-Famira; Peter Daniel; Peter Möller; Peter H Krammer; Klaus-Michael Debatin
APO-1 (CD95) mediated apoptosis in human T-ALL engrafted in SCID mice.
Leukemia 1994;8(11):1825-33.
1994: L R Coney; Peter Daniel; D Sanborn; J Dhein; Klaus-Michael Debatin; Peter H Krammer; V R Zurawski
Apoptotic cell death induced by a mouse-human anti-APO-1 chimeric antibody leads to tumor regression.
International journal of cancer. Journal international du cancer 1994;58(4):562-7.
1994: J Dhein; I Behrmann; Peter Daniel; Klaus-Michael Debatin; C Klas; Peter Möller; A Oehm; B C Trauth; Henning Walczak; Peter H Krammer
APO-I-mediated apoptosis in normal and malignant lymphocytes.
Biochemical Society transactions 1994;22(3):598-600.
1994: Peter H Krammer; I Behrmann; P Daniel; J Dhein; Klaus-Michael Debatin
Regulation of apoptosis in the immune system.
Current opinion in immunology 1994;6(2):279-89.
1994: Klaus-Michael Debatin; D Süss; Peter H Krammer
Differential expression of APO-1 on human thymocytes: implications for negative selection?
European journal of immunology 1994;24(3):753-8.
1993: F Leithäuser; J Dhein; Gunhild Mechtersheimer; K Koretz; Silke Brüderlein; C Henne; A Schmidt; Klaus-Michael Debatin; Peter H Krammer; Peter Möller
Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.
Laboratory investigation; a journal of technical methods and pathology 1993;69(4):415-29.
1993: C Klas; Klaus-Michael Debatin; R R Jonker; Peter H Krammer
Activation interferes with the APO-1 pathway in mature human T cells.
International immunology 1993;5(6):625-30.
1992: M H Falk; B C Trauth; Klaus-Michael Debatin; C Klas; Christopher D Gregory; A B Rickinson; Alain Calender; Gilbert M Lenoir; J W Ellwart; Peter H Krammer
Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype.
Blood 1992;79(12):3300-6.
1990: H Lahm; JR Fischer; Y Reichert; R Hederer; Werner Falk; Klaus-Michael Debatin; P H Krammer
Autocrine growth factors secreted by the malignant human B-cell-line BJAB are distinct from other known cytokines.
European cytokine network 1990;1(1):41-6.
1989: B C Trauth; C Klas; A M Peters; S Matzku; Peter Möller; Werner Falk; Klaus-Michael Debatin; Peter H Krammer
Monoclonal antibody-mediated tumor regression by induction of apoptosis.
Science (New York, N.Y.) 1989;245(4915):301-5.