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Klaus-Michael Debatin

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
65
Fulda, Simone
35
Herr, Ingrid
27
Krammer, Peter
20
Beltinger, Christian
15
Jeremias, Irmela
15
Heinze, Eberhard
15
Wabitsch, Martin
12
Stahnke, Karsten
12
Classen, Carl Friedrich
12
Friedrich, Wilhelm
10
Mattern, Jürgen
9
Walczak, Henning
9
Cario, Holger
9
Kohne, Elisabeth
8
Karges, Beate

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Publications

TOP 3
Gruhn Bernd; Intek Juliane; Pfaffendorf Nadine; Zell Roland; Corbacioglu Selim; Zintl Felix; Beck James F; Debatin Klaus-Michael; Steinbach Daniel
Polymorphism of interleukin-23 receptor gene but not of NOD2/CARD15 is associated with graft-versus-host disease after hematopoietic stem cell transplantation in children.
Ege M J; Meyer L H; Debatin K-M; Stahnke K
Coincidence of recurrent hemiparesis and detection of ALL in a 4-year-old girl: one or two diseases?
Debatin K-M
Growth control of normal and malignant lymphocytes--cell death research from basic concepts to signal pathways and translation into the clinic.

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All Publications

2009: Gruhn Bernd; Intek Juliane; Pfaffendorf Nadine; Zell Roland; Corbacioglu Selim; Zintl Felix; Beck James F; Debatin Klaus-Michael; Steinbach Daniel
Polymorphism of interleukin-23 receptor gene but not of NOD2/CARD15 is associated with graft-versus-host disease after hematopoietic stem cell transplantation in children.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009;15(12):1571-7.
2009: Ege M J; Meyer L H; Debatin K-M; Stahnke K
Coincidence of recurrent hemiparesis and detection of ALL in a 4-year-old girl: one or two diseases?
Klinische Pädiatrie 2009;221(6):386-9.
2009: Debatin K-M
Growth control of normal and malignant lymphocytes--cell death research from basic concepts to signal pathways and translation into the clinic.
Klinische Pädiatrie 2009;221(6):332-8.
2009: Westhoff M-A; Kandenwein J A; Karl S; Vellanki S H K; Braun V; Eramo A; Antoniadis G; Debatin K-M; Fulda S
The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair.
Oncogene 2009;28(40):3586-96.
2009: Sparber-Sauer M; Hönig M; Schulz A S; zur Stadt U; Schütz C; Debatin K M; Friedrich W
Patients with early relapse of primary hemophagocytic syndromes or with persistent CNS involvement may benefit from immediate hematopoietic stem cell transplantation.
Bone marrow transplantation 2009;44(6):333-8.
2009: Vellanki Sri Hari Krishna; Grabrucker Andreas; Liebau Stefan; Proepper Christian; Eramo Adriana; Braun Veit; Boeckers Tobias; Debatin Klaus-Michael; Fulda Simone
Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma.
Neoplasia (New York, N.Y.) 2009;11(8):743-52.
2009: Strauss Gudrun; Lindquist Jonathan A; Arhel Nathalie; Felder Edward; Karl Sabine; Haas Tobias L; Fulda Simone; Walczak Henning; Kirchhoff Frank; Debatin Klaus-Michael
CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling.
The Journal of experimental medicine 2009;206(6):1379-93.
2009: Schinke Thorsten; Schilling Arndt F; Baranowsky Anke; Seitz Sebastian; Marshall Robert P; Linn Tilman; Blaeker Michael; Huebner Antje K; Schulz Ansgar; Simon Ronald; Gebauer Matthias; Priemel Matthias; Kornak Uwe; Perkovic Sandra; Barvencik Florian; Beil F Timo; Del Fattore Andrea; Frattini Annalisa; Streichert Thomas; Pueschel Klaus; Villa Anna; Debatin Klaus-Michael; Rueger Johannes M; Teti Anna; Zustin Jozef; Sauter Guido; Amling Michael
Impaired gastric acidification negatively affects calcium homeostasis and bone mass.
Nature medicine 2009;15(6):674-81.
2009: Vogler Meike; Walczak Henning; Stadel Dominic; Haas Tobias L; Genze Felicitas; Jovanovic Marjana; Bhanot Umesh; Hasel Cornelia; Möller Peter; Gschwend Jürgen E; Simmet Thomas; Debatin Klaus-Michael; Fulda Simone
Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma.
Cancer research 2009;69(6):2425-34.
2009: Ammann Johannes U; Haag Christian; Kasperczyk Hubert; Debatin Klaus-Michael; Fulda Simone
Sensitization of neuroblastoma cells for TRAIL-induced apoptosis by NF-kappaB inhibition.
International journal of cancer. Journal international du cancer 2009;124(6):1301-11.
2009: Fakler Melanie; Loeder Sandra; Vogler Meike; Schneider Katja; Jeremias Irmela; Debatin Klaus-Michael; Fulda Simone
Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance.
Blood 2009;113(8):1710-22.
2009: Fuchs Hans; Posovszky Carsten; Lahr Georgia; van der Werff ten Bosch Jutte; Boehler Thomas; Debatin Klaus-Michael
Residual CD95-pathway function in children with autoimmune lymphoproliferative syndrome is independent from clinical state and genotype of CD95 mutation.
Pediatric research 2009;65(2):163-8.
2009: Kasperczyk Hubert; Baumann Bernd; Debatin Klaus-Michael; Fulda Simone
Characterization of sonic hedgehog as a novel NF-kappaB target gene that promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(1):21-33.
2008: Horenburg S; Fischer-Posovszky P; Debatin K-M; Wabitsch M
Influence of sex hormones on adiponectin expression in human adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2008;40(11):779-86.
2008: von Schnurbein J; Lahr G; Posovszky C; Debatin K M; Wabitsch M
Novel homozygous AIRE mutation in a German patient with severe APECED.
Journal of pediatric endocrinology & metabolism : JPEM 2008;21(10):1003-9.
2008: Vogler Meike; Walczak Henning; Stadel Dominic; Haas Tobias L; Genze Felicitas; Jovanovic Marjana; Gschwend Jürgen E; Simmet Thomas; Debatin Klaus-Michael; Fulda Simone
Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic cancer growth in vitro and in vivo.
Cancer research 2008;68(19):7956-65.
2008: Gruhn B; Taub J W; Ge Y; Beck J F; Zell R; Häfer R; Hermann F H; Debatin K-M; Steinbach D
Prenatal origin of childhood acute lymphoblastic leukemia, association with birth weight and hyperdiploidy.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2008;22(9):1692-7.
2008: Friesen C; Lubatschofski A; Glatting G; Debatin K M; Reske S N
Activation of intrinsic apoptotic pathway by Re-188 irradiation and paclitaxel in coronary artery smooth muscle cells.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology 2008;52(3):289-95.
2008: Opel Daniela; Westhoff Mike-Andrew; Bender Ariane; Braun Veit; Debatin Klaus-Michael; Fulda Simone
Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis.
Cancer research 2008;68(15):6271-80.
2008: Cario Holger; Schwarz Klaus; Herter Jan M; Komrska Vladimir; McMullin Mary F; Minkov Milen; Niemeyer Charlotte; Pospisilova Dagmar; Reinhard Harald; Debatin Klaus-Michael; Pahl Heike L
Clinical and molecular characterisation of a prospectively collected cohort of children and adolescents with polycythemia vera.
British journal of haematology 2008;142(4):622-6.
2008: Friesen Claudia; Uhl Miriam; Pannicke Ulrich; Schwarz Klaus; Miltner Erich; Debatin Klaus-Michael
DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin.
Molecular biology of the cell 2008;19(8):3283-9.
2008: Debatin K-M; Wei J; Beltinger C
Endothelial progenitor cells for cancer gene therapy.
Gene therapy 2008;15(10):780-6.
2008: Ushmorov A; Hogarty M D; Liu X; Knauss H; Debatin K M; Beltinger C
N-myc augments death and attenuates protective effects of Bcl-2 in trophically stressed neuroblastoma cells.
Oncogene 2008;27(24):3424-34.
2008: Karges B; Muche R; Moritz M; Riegger I; Debatin K-M; Heinze E; Wabitsch M; Karges W
Low discomfort and pain associated with intensified insulin therapy in children and adolescents.
Diabetes research and clinical practice 2008;80(1):96-101.
2008: Gatz Susanne Andrea; Keimling Marlen; Baumann Cindy; Dörk Thilo; Debatin Klaus-Michael; Fulda Simone; Wiesmüller Lisa
Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner.
Carcinogenesis 2008;29(3):519-27.
2008: Meyer Lüder H; Queudeville Manon; Eckhoff Sarah M; Creutzig Ursula; Reinhardt Dirk; Karawajew Leonid; Ludwig Wolf-Dieter; Stahnke Karsten; Debatin Klaus-Michael
Intact apoptosis signaling in myeloid leukemia cells determines treatment outcome in childhood AML.
Blood 2008;111(5):2899-903.
2008: Strauss G; Westhoff M-A; Fischer-Posovszky P; Fulda S; Schanbacher M; Eckhoff S M; Stahnke K; Vahsen N; Kroemer G; Debatin K-M
4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG.
Cell death and differentiation 2008;15(2):332-43.
2008: Schmidt Katrin; Schulz Ansgar Stephan; Debatin Klaus-Michael; Friedrich Wilhelm; Classen Carl Friedrich
CNS complications in children receiving chemotherapy or hematopoietic stem cell transplantation: retrospective analysis and clinical study of survivors.
Pediatric blood & cancer 2008;50(2):331-6.
2008: Ehrhardt H; Häcker S; Wittmann S; Maurer M; Borkhardt A; Toloczko A; Debatin K-M; Fulda S; Jeremias I
Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells.
Oncogene 2008;27(6):783-93.
2007: Wei J; Wahl J; Nakamura T; Stiller D; Mertens T; Debatin K-M; Beltinger C
Targeted release of oncolytic measles virus by blood outgrowth endothelial cells in situ inhibits orthotopic gliomas.
Gene therapy 2007;14(22):1573-86.
2007: Giagkousiklidis S; Vellanki S H; Debatin K-M; Fulda S
Sensitization of pancreatic carcinoma cells for gamma-irradiation-induced apoptosis by XIAP inhibition.
Oncogene 2007;26(49):7006-16.
2007: Schuetz C; Barbi G; Barth T F E; Hoenig M; Schulz A; Möeller P; Smeets D; de Greef J C; van der Maarel S M; Vogel W; Debatin K-M; Friedrich W
ICF syndrome: high variability of the chromosomal phenotype and association with classical Hodgkin lymphoma.
American journal of medical genetics. Part A 2007;143A(17):2052-7.
2007: Wei J; Wahl J; Knauss H; Zeller S; Jarmy G; Fitze G; Debatin K-M; Beltinger C
Cytosine deaminase/5-fluorocytosine gene therapy and Apo2L/TRAIL cooperate to kill TRAIL-resistant tumor cells.
Cancer gene therapy 2007;14(7):640-51.
2007: Debatin Klaus-Michael
Chronic lymphocytic leukemia: keeping cell death at bay.
Cell 2007;129(5):853-5.
2007: Karges Beate; Bergmann Carsten; Scholl Katrina; Heinze Eberhard; Rasche Franz Maximilian; Zerres Klaus; Debatin Klaus-Michael; Wabitsch Martin; Karges Wolfram
Digenic inheritance of hepatocyte nuclear factor-1alpha and -1beta with maturity-onset diabetes of the young, polycystic thyroid, and urogenital malformations.
Diabetes care 2007;30(6):1613-4.
2007: Wei Jiwu; Zhou Shaoxia; Bachem Max Georg; Debatin Klaus-Michael; Beltinger Christian
Infiltration of blood outgrowth endothelial cells into tumor spheroids: role of matrix metalloproteinases and irradiation.
Anticancer research 2007;27(3B):1415-21.
2007: Rives Susana; Pahl Heike L; Florensa Lourdes; Bellosillo Beatriz; Neusuess Andrea; Estella Jesus; Debatin Klaus-Michael; Kohne Elisabeth; Schwarz Klaus; Cario Holger
Molecular genetic analyses in familial and sporadic congenital primary erythrocytosis.
Haematologica 2007;92(5):674-7.
2007: Karges Beate; Muche Rainer; Knerr Ina; Ertelt Waldemar; Wiesel Thomas; Hub Regine; Neu Andreas; Klinghammer Albrecht; Aufschild Julia; Rapp Andrea; Schirbel Andreas; Boehm Bernhard O; Debatin Klaus M; Heinze Eberhard; Karges Wolfram
Levothyroxine in euthyroid autoimmune thyroiditis and type 1 diabetes: a randomized, controlled trial.
The Journal of clinical endocrinology and metabolism 2007;92(5):1647-52.
2007: Fulda Simone; Debatin Klaus-Michael
HIF-1-regulated glucose metabolism: a key to apoptosis resistance?
Cell cycle (Georgetown, Tex.) 2007;6(7):790-2.
2007: Hönig Manfred; Albert Michael H; Schulz Ansgar; Sparber-Sauer Monika; Schütz Catharina; Belohradsky Bernd; Güngör Tayfun; Rojewski Markus T; Bode Harald; Pannicke Ulrich; Lippold Dominique; Schwarz Klaus; Debatin Klaus-Michael; Hershfield Michael S; Friedrich Wilhelm
Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications.
Blood 2007;109(8):3595-602.
2007: Fischer-Posovszky P; Kukulus V; Zulet M A; Debatin K M; Wabitsch M
Conjugated linoleic acids promote human fat cell apoptosis.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2007;39(3):186-91.
2007: Friesen Claudia; Glatting Gerhard; Koop Bernd; Schwarz Klaus; Morgenstern Alfred; Apostolidis Christos; Debatin Klaus-Michael; Reske Sven N
Breaking chemoresistance and radioresistance with [213Bi]anti-CD45 antibodies in leukemia cells.
Cancer research 2007;67(5):1950-8.
2007: Wenger T; Mattern J; Haas T L; Sprick M R; Walczak H; Debatin K-M; Büchler M W; Herr I
Apoptosis mediated by lentiviral TRAIL transfer involves transduction-dependent and -independent effects.
Cancer gene therapy 2007;14(3):316-26.
2007: Kilic M; Kasperczyk H; Fulda S; Debatin K-M
Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance.
Oncogene 2007;26(14):2027-38.
2007: Strauss G; Osen W; Knape I; Jacobsen E-M; Müller S M; Debatin K-M
Membrane-bound CD95 ligand expressed on human antigen-presenting cells prevents alloantigen-specific T cell response without impairment of viral and third-party T cell immunity.
Cell death and differentiation 2007;14(3):480-8.
2007: Zhang Chengwen; Wenger Till; Mattern Jürgen; Ilea Septimia; Frey Christian; Gutwein Paul; Altevogt Peter; Bodenmüller Wolfram; Gassler Nikolaus; Schnabel Philipp A; Dienemann Hendrik; Marmé Alexander; Hohenfellner Markus; Haferkamp Axel; Pfitzenmaier Jesco; Gröne Hermann-Josef; Kolb Armin; Büchler Peter; Büchler Markus; Friess Helmut; Rittgen Werner; Edler Lutz; Debatin Klaus-Michael; Krammer Peter H; Rutz Hans P; Herr Ingrid
Clinical and mechanistic aspects of glucocorticoid-induced chemotherapy resistance in the majority of solid tumors.
Cancer biology & therapy 2007;6(2):278-87.
2007: Wei J; Jarmy G; Genuneit J; Debatin K-M; Beltinger C
Human blood late outgrowth endothelial cells for gene therapy of cancer: determinants of efficacy.
Gene therapy 2007;14(4):344-56.
2007: Opel Daniela; Poremba Christopher; Simon Thorsten; Debatin Klaus-Michael; Fulda Simone
Activation of Akt predicts poor outcome in neuroblastoma.
Cancer research 2007;67(2):735-45.
2007: Unger M M; Wahl J; Ushmorov A; Buechele B; Simmet T; Debatin K-M; Beltinger C
Enriching suicide gene bearing tumor cells for an increased bystander effect.
Cancer gene therapy 2007;14(1):30-8.
2007: La Ferla-Brühl K; Westhoff M A; Karl S; Kasperczyk H; Zwacka R M; Debatin K M; Fulda S
NF-kappaB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition.
Oncogene 2007;26(4):571-82.
2007: Vogler M; Dürr K; Jovanovic M; Debatin K-M; Fulda S
Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells.
Oncogene 2007;26(2):248-57.
2006: Karges Beate; Muche Rainer; Riegger Ines; Moritz Martin; Heinze Eberhard; Debatin Klaus-Michael; Wabitsch Martin; Karges Wolfram
Injection of acidic or neutral insulin and pain: a single-center, prospective, controlled, noninterventional study in pediatric patients with type 1 diabetes mellitus.
Clinical therapeutics 2006;28(12):2094-101.
2006: Pauly Eva; Fritzsching Benedikt; Dechant Markus; Fellenberg Joerg; Scheuerpflug Christian Gerold; Debatin Klaus-Michael
Analysis of the CD95 ligand gene in 20 children with autoimmune lymphoproliferative syndrome (ALPS).
Blood 2006;108(10):3622-3; author reply 3623.
2006: Zhang Chengwen; Beckermann Benjamin; Kallifatidis Georgios; Liu Zheng; Rittgen Werner; Edler Lutz; Büchler Peter; Debatin Klaus-Michael; Büchler Markus W; Friess Helmut; Herr Ingrid
Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma.
International journal of oncology 2006;29(5):1295-301.
2006: Corbacioglu Selim; Kilic Mehtap; Westhoff Mike-Andrew; Reinhardt Dirk; Fulda Simone; Debatin Klaus-Michael
Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin.
Blood 2006;108(10):3504-13.
2006: Fulda Simone; Poremba Christopher; Berwanger Bernd; Häcker Sabine; Eilers Martin; Christiansen Holger; Hero Barbara; Debatin Klaus-Michael
Loss of caspase-8 expression does not correlate with MYCN amplification, aggressive disease, or prognosis in neuroblastoma.
Cancer research 2006;66(20):10016-23.
2006: Wenger T; Mattern J; Penzel R; Gassler N; Haas T L; Sprick M R; Walczak H; Krammer P H; Debatin K-M; Herr I
Specific resistance upon lentiviral TRAIL transfer by intracellular retention of TRAIL receptors.
Cell death and differentiation 2006;13(10):1740-51.
2006: Zhang C; Kolb A; Mattern J; Gassler N; Wenger T; Herzer K; Debatin K-M; Büchler M; Friess H; Rittgen W; Edler L; Herr I
Dexamethasone desensitizes hepatocellular and colorectal tumours toward cytotoxic therapy.
Cancer letters 2006;242(1):104-11.
2006: Debatin Klaus-Michael
CD95 system counter attack and prognostic impact.
Onkologie 2006;29(8-9):358-9.
2006: Fulda S; Debatin K-M
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy.
Oncogene 2006;25(34):4798-811.
2006: Meyer Lüder Hinrich; Karawajew Leonid; Schrappe Martin; Ludwig Wolf-Dieter; Debatin Klaus-Michael; Stahnke Karsten
Cytochrome c-related caspase-3 activation determines treatment response and relapse in childhood precursor B-cell ALL.
Blood 2006;107(11):4524-31.
2006: Fulda Simone; Debatin Klaus-Michael
Modulation of apoptosis signaling for cancer therapy.
Archivum immunologiae et therapiae experimentalis 2006;54(3):173-5.
2006: Karges Beate; Durinovic-Belló Ivana; Heinze Eberhard; Debatin Klaus-Michael; Boehm Bernhard; Karges Wolfram
Immunological mechanisms associated with long-term remission of human type 1 diabetes.
Diabetes/metabolism research and reviews 2006;22(3):184-9.
2006: Classen C F; Bird P I; Debatin K-M
Modulation of the granzyme B inhibitor proteinase inhibitor 9 (PI-9) by activation of lymphocytes and monocytes in vitro and by Epstein-Barr virus and bacterial infection.
Clinical and experimental immunology 2006;143(3):534-42.
2006: Ko Hyun Soo; Graf Norbert; Brambs Hans-Jürgen; Debatin Klaus-Michael; Leuschner Ivo; Tröger Jochen; Schenk Jens-Peter
Clinical Quiz. A patient with hematuria and cystic renal mass.
Pediatric nephrology (Berlin, Germany) 2006;21(3):324-7.
2006: Fischer-Posovszky Pamela; Hebestreit Helge; Hofmann Albert K; Strauss Gudrun; Möller Peter; Debatin Klaus-Michael; Wabitsch Martin
Role of CD95-mediated adipocyte loss in autoimmune lipodystrophy.
The Journal of clinical endocrinology and metabolism 2006;91(3):1129-35.
2006: Zhang Chengwen; Marmé Alexander; Wenger Till; Gutwein Paul; Edler Lutz; Rittgen Werner; Debatin Klaus-Michael; Altevogt Peter; Mattern Jürgen; Herr Ingrid
Glucocorticoid-mediated inhibition of chemotherapy in ovarian carcinomas.
International journal of oncology 2006;28(2):551-8.
2006: Fulda Simone; Debatin Klaus-Michael
Targeting inhibitor of apoptosis proteins (IAPs) for diagnosis and treatment of human diseases.
Recent patents on anti-cancer drug discovery 2006;1(1):81-9.
2006: Zhang C; Mattern J; Haferkamp A; Pfitzenmaier J; Hohenfellner M; Rittgen W; Edler L; Debatin K-M; Groene E; Herr I
Corticosteroid-induced chemotherapy resistance in urological cancers.
Cancer biology & therapy 2006;5(1):59-64.
2006: Fulda Simone; Debatin Klaus-Michael
Resveratrol modulation of signal transduction in apoptosis and cell survival: a mini-review.
Cancer detection and prevention 2006;30(3):217-23.
2006: Zhang Chengwen; Kolb Armin; Büchler Peter; Cato Andrew C B; Mattern Jürgen; Rittgen Werner; Edler Lutz; Debatin Klaus-Michael; Büchler Markus W; Friess Helmut; Herr Ingrid
Corticosteroid co-treatment induces resistance to chemotherapy in surgical resections, xenografts and established cell lines of pancreatic cancer.
BMC cancer 2006;6():61.
2005: Giagkousiklidis Stavros; Vogler Meike; Westhoff Mike-Andrew; Kasperczyk Hubert; Debatin Klaus-Michael; Fulda Simone
Sensitization for gamma-irradiation-induced apoptosis by second mitochondria-derived activator of caspase.
Cancer research 2005;65(22):10502-13.
2005: Vogler Meike; Giagkousiklidis Stavros; Genze Felicitas; Gschwend Juergen E; Debatin Klaus-Michael; Fulda Simone
Inhibition of clonogenic tumor growth: a novel function of Smac contributing to its antitumor activity.
Oncogene 2005;24(48):7190-202.
2005: Classen C F; Teigler-Schlegel A; Röttgers S; Reinhardt D; Döhner K; Debatin K M
AML bearing the translocation t(11;17)(q23;q21): involvement of MLL and a region close to RARA, with no differentiation response to retinoic acid.
Annals of hematology 2005;84(12):774-80.
2005: Grigem S; Fischer-Posovszky P; Debatin K M; Loizon E; Vidal H; Wabitsch M
The effect of the HIV protease inhibitor ritonavir on proliferation, differentiation, lipogenesis, gene expression and apoptosis of human preadipocytes and adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2005;37(10):602-9.
2005: Fulda Simone; Debatin Klaus-Michael
HDAC inhibitors: double edge sword for TRAIL cancer therapy?
Cancer biology & therapy 2005;4(10):1113-5.
2005: Kasperczyk Hubert; La Ferla-Brühl Katia; Westhoff Mike Andrew; Behrend Lars; Zwacka Ralf Michael; Debatin Klaus-Michael; Fulda Simone
Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy.
Oncogene 2005;24(46):6945-56.
2005: Baader Eva; Toloczko Agnieszka; Fuchs Uta; Schmid Irene; Beltinger Christian; Ehrhardt Harald; Debatin Klaus-Michael; Jeremias Irmela
Tumor necrosis factor-related apoptosis-inducing ligand-mediated proliferation of tumor cells with receptor-proximal apoptosis defects.
Cancer research 2005;65(17):7888-95.
2005: Karges Beate; Krause Gerd; Homoki Janos; Debatin Klaus-Michael; de Roux Nicolas; Karges Wolfram
TSH receptor mutation V509A causes familial hyperthyroidism by release of interhelical constraints between transmembrane helices TMH3 and TMH5.
The Journal of endocrinology 2005;186(2):377-85.
2005: Jeremias Irmela; Stahnke Karsten; Debatin Klaus-Michael
CD95/Apo-1/Fas: independent cell death induced by doxorubicin in normal cultured cardiomyocytes.
Cancer immunology, immunotherapy : CII 2005;54(7):655-62.
2005: Classen Carl Friedrich; Behnisch Wolfgang; Reinhardt Dirk; Koenig Margit; Möller Peter; Debatin Klaus-Michael
Spontaneous complete and sustained remission of a rearrangement CBP (16p13)-positive disseminated congenital myelosarcoma.
Annals of hematology 2005;84(4):274-5.
2005: Fulda Simone; Debatin Klaus-Michael
Resveratrol-mediated sensitisation to TRAIL-induced apoptosis depends on death receptor and mitochondrial signalling.
European journal of cancer (Oxford, England : 1990) 2005;41(5):786-98.
2005: Gassler N; Zhang C; Wenger T; Schnabel P A; Dienemann H; Debatin K-M; Mattern J; Herr I
Dexamethasone-induced cisplatin and gemcitabine resistance in lung carcinoma samples treated ex vivo.
British journal of cancer 2005;92(6):1084-8.
2005: Mohr Andrea; Zwacka Ralf Michael; Jarmy Gergely; Büneker Chirlei; Schrezenmeier Hubert; Döhner Konstanze; Beltinger Christian; Wiesneth Markus; Debatin Klaus-Michael; Stahnke Karsten
Caspase-8L expression protects CD34+ hematopoietic progenitor cells and leukemic cells from CD95-mediated apoptosis.
Oncogene 2005;24(14):2421-9.
2005: Fulda Simone; Debatin Klaus-Michael
Sensitization for anticancer drug-induced apoptosis by betulinic Acid.
Neoplasia (New York, N.Y.) 2005;7(2):162-70.
2005: Ushmorov Alexey; Debatin Klaus-Michael; Beltinger Christian
Growth inhibition of murine neuroblastoma cells by c-myc with cell cycle arrest in G2/M.
Cancer biology & therapy 2005;4(2):181-6.
2005: Cario Holger; Schwarz Klaus; Jorch Norbert; Kyank Ulrike; Petrides Petro E; Schneider Dominik T; Uhle Renate; Debatin Klaus-Michael; Kohne Elisabeth
Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis.
Haematologica 2005;90(1):19-24.
2004: Fulda Simone; Debatin Klaus-Michael
Apoptosis signaling in tumor therapy.
Annals of the New York Academy of Sciences 2004;1028():150-6.
2004: Fulda Simone; Debatin Klaus-Michael
Exploiting death receptor signaling pathways for tumor therapy.
Biochimica et biophysica acta 2004;1705(1):27-41.
2004: Fulda Simone; Debatin Klaus-Michael
Targeting apoptosis pathways in cancer therapy.
Current cancer drug targets 2004;4(7):569-76.
2004: Classen Carl Friedrich; Ushmorov Alexey; Bird Phillip; Debatin Klaus-Michael
The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias.
Haematologica 2004;89(11):1314-21.
2004: Fulda Simone; Jeremias Irmela; Debatin Klaus-Michael
Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells.
Oncogene 2004;23(46):7611-20.
2004: Mohr A; Zwacka R M; Debatin K-M; Stahnke K
A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release.
Cell death and differentiation 2004;11(10):1153-4.
2004: Fulda Simone; Debatin Klaus-Michael
Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol.
Oncogene 2004;23(40):6702-11.
2004: Fulda Simone; Debatin Klaus-Michael
Signaling through death receptors in cancer therapy.
Current opinion in pharmacology 2004;4(4):327-32.
2004: Ehrhardt H; Fulda S; Führer M; Debatin K M; Jeremias I
Betulinic acid-induced apoptosis in leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(8):1406-12.
2004: Jeremias I; Steiner H H; Benner A; Debatin K-M; Herold-Mende C
Cell death induction by betulinic acid, ceramide and TRAIL in primary glioblastoma multiforme cells.
Acta neurochirurgica 2004;146(7):721-9.
2004: Stahnke K; Mohr A; Liu J; Meyer L H; Karawajew L; Debatin K-M
Identification of deficient mitochondrial signaling in apoptosis resistant leukemia cells by flow cytometric analysis of intracellular cytochrome c, caspase-3 and apoptosis.
Apoptosis : an international journal on programmed cell death 2004;9(4):457-65.
2004: Friesen C; Kiess Y; Debatin K-M
A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells.
Cell death and differentiation 2004;11 Suppl 1():S73-85.
2004: Cario H; Schwarz K; Debatin K-M; Kohne E
Congenital erythrocytosis and polycythemia vera in childhood and adolescence.
Klinische Pädiatrie 2004;216(3):157-62.
2004: Wei Jiwu; Blum Sabine; Unger Marcus; Jarmy Gergely; Lamparter Mathias; Geishauser Albert; Vlastos Georgios A; Chan Gordon; Fischer Klaus-Dieter; Rattat Dirk; Debatin Klaus-Michael; Hatzopoulos Antonis K; Beltinger Christian
Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery.
Cancer cell 2004;5(5):477-88.
2004: Karges Beate; Durinovic-Belló Ivana; Heinze Eberhard; Boehm Bernhard O; Debatin Klaus-Michael; Karges Wolfram
Complete long-term recovery of beta-cell function in autoimmune type 1 diabetes after insulin treatment.
Diabetes care 2004;27(5):1207-8.
2004: Dechant Markus J; Fellenberg Jörg; Scheuerpflug Christian G; Ewerbeck Volker; Debatin Klaus-Michael
Mutation analysis of the apoptotic "death-receptors" and the adaptors TRADD and FADD/MORT-1 in osteosarcoma tumor samples and osteosarcoma cell lines.
International journal of cancer. Journal international du cancer 2004;109(5):661-7.
2004: Debatin Klaus-Michael; Krammer Peter H
Death receptors in chemotherapy and cancer.
Oncogene 2004;23(16):2950-66.
2004: Fischer-Posovszky Pamela; Tornqvist Hans; Debatin Klaus-Michael; Wabitsch Martin
Inhibition of death-receptor mediated apoptosis in human adipocytes by the insulin-like growth factor I (IGF-I)/IGF-I receptor autocrine circuit.
Endocrinology 2004;145(4):1849-59.
2004: Debatin Klaus-Michael
Apoptosis pathways in cancer and cancer therapy.
Cancer immunology, immunotherapy : CII 2004;53(3):153-9.
2004: Wabitsch M; Hauner H; Hertrampf M; Muche R; Hay B; Mayer H; Kratzer W; Debatin K-M; Heinze E
Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(2):307-13.
2004: Okouoyo Stella; Herzer Kerstin; Ucur Esat; Mattern Jürgen; Krammer Peter H; Debatin Klaus-Michael; Herr Ingrid
Rescue of death receptor and mitochondrial apoptosis signaling in resistant human NSCLC in vivo.
International journal of cancer. Journal international du cancer 2004;108(4):580-7.
2004: Fulda Simone; Debatin Klaus-Michael
Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol.
Cancer research 2004;64(1):337-46.
2004: Karges Beate; LeHeup Bruno; Schoenle Eugen; Castro-Correia Cintia; Fontoura Manuel; Pfäffle Roland; Andler Werner; Debatin Klaus-Michael; Karges Wolfram
Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe.
Hormone research 2004;62(3):149-55.
2004: Fulda Simone; Debatin Klaus-Michael
Modulation of TRAIL signaling for cancer therapy.
Vitamins and hormones 2004;67():275-90.
2003: Denzer Christian; Muche Rainer; Mayer Hermann; Heinze Eberhard; Debatin Klaus-Michael; Wabitsch Martin
Serum uric acid levels in obese children and adolescents: linkage to testosterone levels and pre-metabolic syndrome.
Journal of pediatric endocrinology & metabolism : JPEM 2003;16(9):1225-32.
2003: Ucur E; Mattern J; Wenger T; Okouoyo S; Schroth A; Debatin K-M; Herr I
Induction of apoptosis in experimental human B cell lymphomas by conditional TRAIL-expressing T cells.
British journal of cancer 2003;89(11):2155-62.
2003: Sommerburg Olaf; Langhans Claus-Dieter; Arnhold Jürgen; Leichsenring Michael; Salerno Costantino; Crifò Carlo; Hoffmann Georg F; Debatin Klaus-Michael; Siems Werner G
Beta-carotene cleavage products after oxidation mediated by hypochlorous acid--a model for neutrophil-derived degradation.
Free radical biology & medicine 2003;35(11):1480-90.
2003: Van Valen Frans; Fulda Simone; Schäfer Karl-Ludwig; Truckenbrod Borna; Hotfilder Marc; Poremba Christopher; Debatin Klaus-Michael; Winkelmann Winfried
Selective and nonselective toxicity of TRAIL/Apo2L combined with chemotherapy in human bone tumour cells vs. normal human cells.
International journal of cancer. Journal international du cancer 2003;107(6):929-40.
2003: Stahnke K; Eckhoff S; Mohr A; Meyer L H; Debatin K-M
Apoptosis induction in peripheral leukemia cells by remission induction treatment in vivo: selective depletion and apoptosis in a CD34+ subpopulation of leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2003;17(11):2130-9.
2003: Krilleke Dominik; Ucur Esat; Pulte Dianne; Schulze-Osthoff Klaus; Debatin Klaus-Michael; Herr Ingrid
Inhibition of JNK signaling diminishes early but not late cellular stress-induced apoptosis.
International journal of cancer. Journal international du cancer 2003;107(4):520-7.
2003: Cario Holger; Pahl Heike L; Schwarz Klaus; Galm Christoph; Hoffmann Martin; Burdelski Martin; Kohne Elisabeth; Debatin Klaus-Michael
Familial polycythemia vera with Budd-Chiari syndrome in childhood.
British journal of haematology 2003;123(2):346-52.
2003: Classen C F; Debatin K-M; Friedrich W; Schulz A S
Long-term remission of APL with a second allogeneic BMT after CNS relapse following HLA-identical allogeneic BMT.
Bone marrow transplantation 2003;32(8):843-6.
2003: Friesen Claudia; Lubatschofski Annelie; Kotzerke Jörg; Buchmann Inga; Reske Sven N; Debatin Klaus-Michael
Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cells.
European journal of nuclear medicine and molecular imaging 2003;30(9):1251-61.
2003: Classen C F; Gnekow A; Debatin K-M
Terminal differentiation in vitro of patient-derived post-TMD megakaryoblastic AML cells.
Annals of hematology 2003;82(8):506-10.
2003: Strauss Gudrun; Knape Ingrid; Melzner Ingo; Debatin Klaus-Michael
Constitutive caspase activation and impaired death-inducing signaling complex formation in CD95-resistant, long-term activated, antigen-specific T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1172-82.
2003: Fulda Simone; Debatin Klaus Michael
Apoptosis pathways in neuroblastoma therapy.
Cancer letters 2003;197(1-2):131-5.
2003: Fulda Simone; Debatin Klaus-Michael
Death receptor signaling in cancer therapy.
Current medicinal chemistry. Anti-cancer agents 2003;3(4):253-62.
2003: Ehrhardt Harald; Fulda Simone; Schmid Irene; Hiscott John; Debatin Klaus-Michael; Jeremias Irmela
TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.
Oncogene 2003;22(25):3842-52.
2003: Herr Ingrid; Ucur Esat; Herzer Kerstin; Okouoyo Stella; Ridder Rüdiger; Krammer Peter H; von Knebel Doeberitz Magnus; Debatin Klaus-Michael
Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas.
Cancer research 2003;63(12):3112-20.
2003: Eggermann Juliane; Kliche Stefanie; Jarmy Gergely; Hoffmann Karin; Mayr-Beyrle Ulrike; Debatin Klaus Michael; Waltenberger Johannes; Beltinger Christian
Endothelial progenitor cell culture and differentiation in vitro: a methodological comparison using human umbilical cord blood.
Cardiovascular research 2003;58(2):478-86.
2003: Classen Carl Friedrich; Falk Christine S; Friesen Claudia; Fulda Simone; Herr Ingrid; Debatin Klaus-Michael
Natural killer resistance of a drug-resistant leukemia cell line, mediated by up-regulation of HLA class I expression.
Haematologica 2003;88(5):509-21.
2003: Debatin Klaus Michael; Stahnke Karsten; Fulda Simone
Apoptosis in hematological disorders.
Seminars in cancer biology 2003;13(2):149-58.
2003: Debatin Klaus-Michael
Role of apoptosis in congenital hematologic disorders and bone marrow failure.
Reviews in clinical and experimental hematology 2003;7(1):57-71.
2003: Cario Holger; Holl Reinhard W; Debatin Klaus-Michael M; Kohne Elisabeth
Insulin sensitivity and beta-cell secretion in thalassaemia major with secondary haemochromatosis: assessment by oral glucose tolerance test.
European journal of pediatrics 2003;162(3):139-46.
2003: Fulda Simone; Debatin Klaus Michael
Apoptosis pathways: turned on their heads?
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2003;6(1):1-3.
2003: Cario Holger; Holl Reinhard W; Debatin Klaus-Michael; Kohne Elisabeth
Disproportionately elevated fasting proinsulin levels in normoglycemic patients with thalassemia major are correlated to the degree of iron overload.
Hormone research 2003;59(2):73-8.
2002: Debatin Klaus-Michael; Poncet Delphine; Kroemer Guido
Chemotherapy: targeting the mitochondrial cell death pathway.
Oncogene 2002;21(57):8786-803.
2002: Reuter Ursula; Roesler Joachim; Thiede Christian; Schulz Ansgar; Classen Carl Friedrich; Oelschlagel Uta; Debatin Klaus-Michael; Friedrich Wilhelm
Correction of complete interferon-gamma receptor 1 deficiency by bone marrow transplantation.
Blood 2002;100(12):4234-5.
2002: Liptay Susanne; Fulda Simone; Schanbacher Marta; Bourteele Soizic; Ferri Karine F; Kroemer Guido; Adler Guido; Debatin Klaus M; Schmid Roland M
Molecular mechanisms of sulfasalazine-induced T-cell apoptosis.
British journal of pharmacology 2002;137(5):608-20.
2002: Baumann Bernd; Bohnenstengel Frank; Siegmund Daniela; Wajant Harald; Weber Christoph; Herr Ingrid; Debatin Klaus-Michael; Proksch Peter; Wirth Thomas
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells.
The Journal of biological chemistry 2002;277(47):44791-800.
2002: Cario H; Wegener M; Debatin K-M; Kohne E
Treatment with hydroxyurea in thalassemia intermedia with paravertebral pseudotumors of extramedullary hematopoiesis.
Annals of hematology 2002;81(8):478-82.
2002: Fulda Simone; Wick Wolfgang; Weller Michael; Debatin Klaus-Michael
Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.
Nature medicine 2002;8(8):808-15.
2002: Fischer-Posovszky Pamela; Debatin K M; Wabitsch M
[Lipodystrophies]
Klinische Pädiatrie 2002;214(3):99-103.
2002: Fischer Pamela; Möller Peter; Bindl Lutz; Melzner Ingo; Tornqvist Hans; Debatin Klaus-Michael; Wabitsch Martin
Induction of adipocyte differentiation by a thiazolidinedione in cultured, subepidermal, fibroblast-like cells of an infant with congenital generalized lipodystrophy.
The Journal of clinical endocrinology and metabolism 2002;87(5):2384-90.
2002: Strauss G; Osen W; Debatin K-M
Induction of apoptosis and modulation of activation and effector function in T cells by immunosuppressive drugs.
Clinical and experimental immunology 2002;128(2):255-66.
2002: Schulz Ansgar S; Classen Carl Friedrich; Mihatsch Walther A; Sigl-Kraetzig Michael; Wiesneth Markus; Debatin Klaus-Michael; Friedrich Wilhelm; Müller Susanna M
HLA-haploidentical blood progenitor cell transplantation in osteopetrosis.
Blood 2002;99(9):3458-60.
2002: Beltinger Christian; Fulda Simone; Walczak Henning; Debatin Klaus-Michael
TRAIL enhances thymidine kinase/ganciclovir gene therapy of neuroblastoma cells.
Cancer gene therapy 2002;9(4):372-81.
2002: Fulda Simone; Debatin Klaus-Michael
IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway.
Oncogene 2002;21(15):2295-308.
2002: Fulda Simone; Meyer Eric; Debatin Klaus-Michael
Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression.
Oncogene 2002;21(15):2283-94.
2001: Ege M; Manfras B J; Barbi G; Schulz A S; Sigl-Kraetzig M; Debatin K M; Friedrich W; Mueller S M
Eradication of a dysfunctional HLA-haploidentical T cell system by a second HLA-identical BMT.
Bone marrow transplantation 2001;28(10):993-5.
2001: Stahnke K; Fulda S; Friesen C; Strauss G; Debatin K M
Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy.
Blood 2001;98(10):3066-73.
2001: Herr I; Debatin K M
Cellular stress response and apoptosis in cancer therapy.
Blood 2001;98(9):2603-14.
2001: Fulda S; Küfer M U; Meyer E; van Valen F; Dockhorn-Dworniczak B; Debatin K M
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer.
Oncogene 2001;20(41):5865-77.
2001: Classen C F; Schulz A S; Debatin K M; Friedrich W
Severe persistent neuropsychiatric toxicity after a human leucocyte antigen-non-identical peripheral blood stem cell transplantation (total body irradiation, etoposide, thiotepa) and interleukin 2-based experimental therapy for poor prognosis relapse acute lymphoblastic leukaemia.
British journal of haematology 2001;114(2):487-9.
2001: Classen C F; Schulz A S; Sigl-Kraetzig M; Hoffmann G F; Simmonds H A; Fairbanks L; Debatin K M; Friedrich W
Successful HLA-identical bone marrow transplantation in a patient with PNP deficiency using busulfan and fludarabine for conditioning.
Bone marrow transplantation 2001;28(1):93-6.
2001: Lindner W; Behnisch W; Kunz U; Debatin K M; Pohlandt F
Congenital neuroblastoma mimicking early onset sepsis.
European journal of pediatrics 2001;160(7):436-8.
2001: Beltinger C; Debatin K M
Murine models for experimental therapy of pediatric solid tumors with poor prognosis.
International journal of cancer. Journal international du cancer 2001;92(3):313-8.
2001: Fulda S; Meyer E; Friesen C; Susin S A; Kroemer G; Debatin K M
Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis.
Oncogene 2001;20(9):1063-75.
2001: Wabitsch M; Brenner R E; Melzner I; Braun M; Möller P; Heinze E; Debatin K M; Hauner H
Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(1):8-15.
2001: Böhler T; Wintergerst U; Linde R; Belohradsky B H; Debatin K M
CD95 (APO-1/Fas) expression on naive CD4(+) T cells increases with disease progression in HIV-infected children and adolescents: effect of highly active antiretroviral therapy (HAART).
Pediatric research 2001;49(1):101-10.
2001: Debatin K M
Cell death in T- and B-cell development.
Annals of hematology 2001;80 Suppl 3():B29-31.
2001: Scheuerpflug C G; Lichter P; Debatin K M; Mincheva A
Assignment of TRADD to human chromosome band 16q22 by in situ hybridization.
Cytogenetics and cell genetics 2001;92(3-4):347-8.
2000: Müller S M; Kohn T; Schulz A S; Debatin K M; Friedrich W
Similar pattern of thymic-dependent T-cell reconstitution in infants with severe combined immunodeficiency after human leukocyte antigen (HLA)-identical and HLA-nonidentical stem cell transplantation.
Blood 2000;96(13):4344-9.
2000: Fulda S; Debatin K M
Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors.
Medical and pediatric oncology 2000;35(6):616-8.
2000: Fulda S; Lutz W; Schwab M; Debatin K M
MycN sensitizes neuroblastoma cells for drug-triggered apoptosis.
Medical and pediatric oncology 2000;35(6):582-4.
2000: Wabitsch M; Heinze E; Debatin K M; Blum W F
IGF-I- and IGFBP-3-expression in cultured human preadipocytes and adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2000;32(11-12):555-9.
2000: Herr I; Krilleke D; Debatin K M
A sensitive, non-radioactive and fast method for detection of JNK/SAPK activity in leukemic T cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(10):1859-60.
2000: Van Valen F; Fulda S; Truckenbrod B; Eckervogt V; Sonnemann J; Hillmann A; Rödl R; Hoffmann C; Winkelmann W; Schäfer L; Dockhorn-Dworniczak B; Wessel T; Boos J; Debatin K M; Jürgens H
Apoptotic responsiveness of the Ewing's sarcoma family of tumours to tumour necrosis factor-related apoptosis-inducing ligand (TRAIL).
International journal of cancer. Journal international du cancer 2000;88(2):252-9.
2000: Herr I; Posovszky C; Di Marzio L D; Cifone M G; Boehler T; Debatin K M
Autoamplification of apoptosis following ligation of CD95-L, TRAIL and TNF-alpha.
Oncogene 2000;19(37):4255-62.
2000: Jeremias I; Kupatt C; Martin-Villalba A; Habazettl H; Schenkel J; Boekstegers P; Debatin K M
Involvement of CD95/Apo1/Fas in cell death after myocardial ischemia.
Circulation 2000;102(8):915-20.
2000: Fulda S; Meyer E; Debatin K M
Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression.
Cancer research 2000;60(14):3947-56.
2000: Beltinger C; Fulda S; Kammertoens T; Uckert W; Debatin K M
Mitochondrial amplification of death signals determines thymidine kinase/ganciclovir-triggered activation of apoptosis.
Cancer research 2000;60(12):3212-7.
2000: Fellenberg J; Mau H; Nedel S; Ewerbeck V; Debatin K M
Drug-induced apoptosis in osteosarcoma cell lines is mediated by caspase activation independent of CD95-receptor/ligand interaction.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(1):10-7.
2000: Kolbus A; Herr I; Schreiber M; Debatin K M; Wagner E F; Angel P
c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents.
Molecular and cellular biology 2000;20(2):575-82.
2000: Fulda S; Strauss G; Meyer E; Debatin K M
Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells.
Blood 2000;95(1):301-8.
2000: Sergi C; Böhler T; Schönrich G; Sieverts H; Roth S U; Debatin K M; Otto H F
Occult thyroid pathology in a child with acquired immunodeficiency syndrome. Case report and review of the drug-related pathology in pediatric acquired immunodeficiency syndrome.
Pathology oncology research : POR 2000;6(3):227-32.
1999: Liptay S; Bachem M; Häcker G; Adler G; Debatin K M; Schmid R M
Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine.
British journal of pharmacology 1999;128(7):1361-9.
1999: Friesen C; Fulda S; Debatin K M
Cytotoxic drugs and the CD95 pathway.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(11):1854-8.
1999: Böhler T; Debatin K M; Linde R
Sensitivity of CD4+ peripheral blood T cells toward spontaneous and CD95 (APO-1/Fas)-induced apoptosis in pediatric human immunodeficiency virus infection.
Blood 1999;94(5):1829-33.
1999: Müller S; Schulz A; Reiss U; Schwarz K; Schreiner T; Wiesneth M; Debatin K M; Friedrich W
Definition of a critical T cell threshold for prevention of GVHD after HLA non-identical PBPC transplantation in children.
Bone marrow transplantation 1999;24(6):575-81.
1999: Böhler T; Walcher J; Hölzl-Wenig G; Schnitzler P; Geiss M; Buchholz B; Linde R; Rütschle H; Debatin K M
Expression of CD69 on T-cells from HIV-1-infected children and adolescents increases with increasing viral load.
European journal of pediatrics 1999;158(8):638-44.
1999: Fulda S; Jeremias I; Pietsch T; Debatin K M
Betulinic acid: a new chemotherapeutic agent in the treatment of neuroectodermal tumors.
Klinische Pädiatrie 1999;211(4):319-22.
1999: Bernassola F; Scheuerpflug C; Herr I; Krammer P H; Debatin K M; Melino G
Induction of apoptosis by IFNgamma in human neuroblastoma cell lines through the CD95/CD95L autocrine circuit.
Cell death and differentiation 1999;6(7):652-60.
1999: Beltinger C; Fulda S; Kammertoens T; Meyer E; Uckert W; Debatin K M
Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8699-704.
1999: Fulda S; Jeremias I; Steiner H H; Pietsch T; Debatin K M
Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells.
International journal of cancer. Journal international du cancer 1999;82(3):435-41.
1999: Friesen C; Fulda S; Debatin K M
Induction of CD95 ligand and apoptosis by doxorubicin is modulated by the redox state in chemosensitive- and drug-resistant tumor cells.
Cell death and differentiation 1999;6(5):471-80.
1999: Böhler T; Walcher J; Hölzl-Wenig G; Geiss M; Buchholz B; Linde R; Debatin K M
Early effects of antiretroviral combination therapy on activation, apoptosis and regeneration of T cells in HIV-1-infected children and adolescents.
AIDS (London, England) 1999;13(7):779-89.
1999: Martin-Villalba A; Herr I; Jeremias I; Hahne M; Brandt R; Vogel J; Schenkel J; Herdegen T; Debatin K M
CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(10):3809-17.
1999: Herr I; Martin-Villalba A; Kurz E; Roncaioli P; Schenkel J; Cifone M G; Debatin K M
FK506 prevents stroke-induced generation of ceramide and apoptosis signaling.
Brain research 1999;826(2):210-9.
1999: Classen C F; Fulda S; Friesen C; Debatin K M
Decreased sensitivity of drug-resistant cells towards T cell cytotoxicity.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(3):410-8.
1999: Posovszky C; Friesen C; Herr I; Debatin K M
Chemotherapeutic drugs sensitize pre-B ALL cells for CD95- and cytotoxic T-lymphocyte-mediated apoptosis.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(3):400-9.
1999: Herr I; Wilhelm D; Meyer E; Jeremias I; Angel P; Debatin K M
JNK/SAPK activity contributes to TRAIL-induced apoptosis.
Cell death and differentiation 1999;6(2):130-5.
1999: Fulda S; Lutz W; Schwab M; Debatin K M
MycN sensitizes neuroblastoma cells for drug-induced apoptosis.
Oncogene 1999;18(7):1479-86.
1999: Herr I; Wilhelm D; Böhler T; Angel P; Debatin K M
JNK/SAPK activity is not sufficient for anticancer therapy-induced apoptosis involving CD95-L, TRAIL and TNF-alpha.
International journal of cancer. Journal international du cancer 1999;80(3):417-24.
1999: Holl R W; Bucher P; Sorgo W; Heinze E; Homoki J; Debatin K M
Suppression of growth hormone by oral glucose in the evaluation of tall stature.
Hormone research 1999;51(1):20-4.
1998: Jeremias I; Debatin K M
TRAIL induces apoptosis and activation of NFkappaB.
European cytokine network 1998;9(4):687-8.
1998: Holl R W; Grabert M; Heinze E; Sorgo W; Debatin K M
Age at onset and long-term metabolic control affect height in type-1 diabetes mellitus.
European journal of pediatrics 1998;157(12):972-7.
1998: Fulda S; Scaffidi C; Susin S A; Krammer P H; Kroemer G; Peter M E; Debatin K M
Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid.
The Journal of biological chemistry 1998;273(51):33942-8.
1998: Fulda S; Scaffidi C; Pietsch T; Krammer P H; Peter M E; Debatin K M
Activation of the CD95 (APO-1/Fas) pathway in drug- and gamma-irradiation-induced apoptosis of brain tumor cells.
Cell death and differentiation 1998;5(10):884-93.
1998: Fulda S; Susin S A; Kroemer G; Debatin K M
Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells.
Cancer research 1998;58(19):4453-60.
1998: Beltinger C; Böhler T; Karawajew L; Ludwig W D; Schrappe M; Debatin K M
Mutation analysis of CD95 (APO-1/Fas) in childhood B-lineage acute lymphoblastic leukaemia.
British journal of haematology 1998;102(3):722-8.
1998: Stahnke K; Hecker S; Kohne E; Debatin K M
CD95 (APO-1/FAS)-mediated apoptosis in cytokine-activated hematopoietic cells.
Experimental hematology 1998;26(9):844-50.
1998: Beltinger C; Böhler T; Schrappe M; Ludwig W D; Debatin K M
[The role of CD95 (APO-1/Fas) mutations in lymphoproliferative and malignant lymphatic diseases]
Klinische Pädiatrie 1998;210(4):153-8.
1998: Fulda S; Friesen C; Debatin K M
Molecular determinants of apoptosis induced by cytotoxic drugs.
Klinische Pädiatrie 1998;210(4):148-52.
1998: Lutz W; Fulda S; Jeremias I; Debatin K M; Schwab M
MycN and IFNgamma cooperate in apoptosis of human neuroblastoma cells.
Oncogene 1998;17(3):339-46.
1998: Jeremias I; Kupatt C; Baumann B; Herr I; Wirth T; Debatin K M
Inhibition of nuclear factor kappaB activation attenuates apoptosis resistance in lymphoid cells.
Blood 1998;91(12):4624-31.
1998: Holl R W; Grabert M; Sorgo W; Heinze E; Debatin K M
Contributions of age, gender and insulin administration to weight gain in subjects with IDDM.
Diabetologia 1998;41(5):542-7.
1998: Holl R W; Lang G E; Grabert M; Heinze E; Lang G K; Debatin K M
Diabetic retinopathy in pediatric patients with type-1 diabetes: effect of diabetes duration, prepubertal and pubertal onset of diabetes, and metabolic control.
The Journal of pediatrics 1998;132(5):790-4.
1998: Holl R W; Grabert M; Heinze E; Debatin K M
Objective assessment of smoking habits by urinary cotinine measurement in adolescents and young adults with type 1 diabetes. Reliability of reported cigarette consumption and relationship to urinary albumin excretion.
Diabetes care 1998;21(5):787-91.
1998: Beltinger C; Kurz E; Böhler T; Schrappe M; Ludwig W D; Debatin K M
CD95 (APO-1/Fas) mutations in childhood T-lineage acute lymphoblastic leukemia.
Blood 1998;91(10):3943-51.
1998: Holl R W; Buck C; Cario H; Wolf A; Thon A; Kohne E; Debatin K M
Diagnosis of diabetes in cystic fibrosis and thalassemia major.
Diabetes care 1998;21(4):671-2.
1998: Stricker K; Knipping E; Böhler T; Benner A; Krammer P H; Debatin K M
Anti-CD95 (APO-1/Fas) autoantibodies and T cell depletion in human immunodeficiency virus type 1 (HIV-1)-infected children.
Cell death and differentiation 1998;5(3):222-30.
1998: Fulda S; Los M; Friesen C; Debatin K M
Chemosensitivity of solid tumor cells in vitro is related to activation of the CD95 system.
International journal of cancer. Journal international du cancer 1998;76(1):105-14.
1998: Scaffidi C; Fulda S; Srinivasan A; Friesen C; Li F; Tomaselli K J; Debatin K M; Krammer P H; Peter M E
Two CD95 (APO-1/Fas) signaling pathways.
The EMBO journal 1998;17(6):1675-87.
1998: Jeremias I; Herr I; Boehler T; Debatin K M
TRAIL/Apo-2-ligand-induced apoptosis in human T cells.
European journal of immunology 1998;28(1):143-52.
1998: Debatin K M
CD95 (APO-1/Fas) in hematopoietic diseases.
Results and problems in cell differentiation 1998;24():157-74.
1997: Friesen C; Fulda S; Debatin K M
Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(11):1833-41.
1997: Fulda S; Friesen C; Los M; Scaffidi C; Mier W; Benedict M; Nuñez G; Krammer P H; Peter M E; Debatin K M
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.
Cancer research 1997;57(21):4956-64.
1997: Los M; Herr I; Friesen C; Fulda S; Schulze-Osthoff K; Debatin K M
Cross-resistance of CD95- and drug-induced apoptosis as a consequence of deficient activation of caspases (ICE/Ced-3 proteases).
Blood 1997;90(8):3118-29.
1997: Herr I; Wilhelm D; Böhler T; Angel P; Debatin K M
Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis.
The EMBO journal 1997;16(20):6200-8.
1997: Fulda S; Sieverts H; Friesen C; Herr I; Debatin K M
The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells.
Cancer research 1997;57(17):3823-9.
1997: Böhler T; Bäumler C; Herr I; Groll A; Kurz M; Debatin K M
Activation of the CD95 system increases with disease progression in human immunodeficiency virus type 1-infected children and adolescents.
The Pediatric infectious disease journal 1997;16(8):754-9.
1997: Fellenberg J; Mau H; Scheuerpflug C; Ewerbeck V; Debatin K M
Modulation of resistance to anti-APO-1-induced apoptosis in osteosarcoma cells by cytokines.
International journal of cancer. Journal international du cancer 1997;72(3):536-42.
1997: Böhler T; Herr I; Debatin K M; Geiss M; Haas J
Downregulation of increased CD95 (APO-1/Fas) ligand in T cells from human immunodeficiency virus-type 1-infected children after antiretroviral therapy.
Blood 1997;90(2):886-8.
1997: Böhler T; Nedel S; Debatin K M
CD95-induced apoptosis contributes to loss of primed/memory but not resting/naive T cells in children infected with human immunodeficiency virus type 1.
Pediatric research 1997;41(6):878-85.
1997: Debatin K M; Beltinger C; Böhler T; Fellenberg J; Friesen C; Fulda S; Herr I; Los M; Scheuerpflug C; Sieverts H; Stahnke K
Regulation of apoptosis through CD95 (APO-I/Fas) receptor-ligand interaction.
Biochemical Society transactions 1997;25(2):405-10.
1997: Peter M E; Kischkel F C; Scheuerpflug C G; Medema J P; Debatin K M; Krammer P H
Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex.
European journal of immunology 1997;27(5):1207-12.
1996: Csóka M; Strauss G; Debatin K M; Moldenhauer G
Activation of T cell cytotoxicity against autologous common acute lymphoblastic leukemia (cALL) blasts by CD3xCD19 bispecific antibody.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1996;10(11):1765-72.
1996: Bäumler C B; Böhler T; Herr I; Benner A; Krammer P H; Debatin K M
Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children.
Blood 1996;88(5):1741-6.
1996: Ehret A; Westendorp M O; Herr I; Debatin K M; Heeney J L; Frank R; Krammer P H
Resistance of chimpanzee T cells to human immunodeficiency virus type 1 Tat-enhanced oxidative stress and apoptosis.
Journal of virology 1996;70(9):6502-7.
1996: Herr I; Balemans L; Böhler T; Walczak H; Debatin K M
Monitoring of CD95 (APO-1/Fas) ligand expression in human T cells by quantitative RT-PCR.
Cell death and differentiation 1996;3(3):299-305.
1996: Friesen C; Herr I; Krammer P H; Debatin K M
Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells.
Nature medicine 1996;2(5):574-7.
1996: Debatin K M
Disturbances of the CD95 (APO-1/Fas) system in disorders of lymphohaematopoietic cells.
Cell death and differentiation 1996;3(2):185-9.
1995: Dhein J; Walczak H; Westendorp M O; Bäumler C; Stricker K; Frank R; Debatin K M; Krammer P H
Molecular mechanisms of APO-1/Fas(CD95)-mediated apoptosis in tolerance and AIDS.
Behring Institute Mitteilungen 1995;(96):13-20.
1995: Westendorp M O; Frank R; Ochsenbauer C; Stricker K; Dhein J; Walczak H; Debatin K M; Krammer P H
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.
Nature 1995;375(6531):497-500.
1995: Debatin K M; Krammer P H
Resistance to APO-1 (CD95) induced apoptosis in T-ALL is determined by a BCL-2 independent anti-apoptotic program.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(5):815-20.
1995: Knipping E; Debatin K M; Stricker K; Heilig B; Eder A; Krammer P H
Identification of soluble APO-1 in supernatants of human B- and T-cell lines and increased serum levels in B- and T-cell leukemias.
Blood 1995;85(6):1562-9.
1995: Dhein J; Walczak H; Bäumler C; Debatin K M; Krammer P H
Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
Nature 1995;373(6513):438-41.
1994: Lücking-Famira K M; Daniel P T; Möller P; Krammer P H; Debatin K M
APO-1 (CD95) mediated apoptosis in human T-ALL engrafted in SCID mice.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(11):1825-33.
1994: Dhein J; Behrmann I; Daniel P T; Debatin K M; Klas C; Möller P; Oehm A; Trauth B C; Walczak H; Krammer P H
APO-I-mediated apoptosis in normal and malignant lymphocytes.
Biochemical Society transactions 1994;22(3):598-600.
1994: Coney L R; Daniel P T; Sanborn D; Dhein J; Debatin K M; Krammer P H; Zurawski V R
Apoptotic cell death induced by a mouse-human anti-APO-1 chimeric antibody leads to tumor regression.
International journal of cancer. Journal international du cancer 1994;58(4):562-7.
1994: Krammer P H; Behrmann I; Daniel P; Dhein J; Debatin K M
Regulation of apoptosis in the immune system.
Current opinion in immunology 1994;6(2):279-89.
1994: Debatin K M; Süss D; Krammer P H
Differential expression of APO-1 on human thymocytes: implications for negative selection?
European journal of immunology 1994;24(3):753-8.
1993: Leithäuser F; Dhein J; Mechtersheimer G; Koretz K; Brüderlein S; Henne C; Schmidt A; Debatin K M; Krammer P H; Möller P
Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.
Laboratory investigation; a journal of technical methods and pathology 1993;69(4):415-29.
1993: Klas C; Debatin K M; Jonker R R; Krammer P H
Activation interferes with the APO-1 pathway in mature human T cells.
International immunology 1993;5(6):625-30.
1992: Falk M H; Trauth B C; Debatin K M; Klas C; Gregory C D; Rickinson A B; Calender A; Lenoir G M; Ellwart J W; Krammer P H
Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype.
Blood 1992;79(12):3300-6.
1990: Lahm H; Fischer J R; Reichert Y; Hederer R; Falk W; Debatin K M; Krammer P H
Autocrine growth factors secreted by the malignant human B-cell-line BJAB are distinct from other known cytokines.
European cytokine network 1990;1(1):41-6.
1989: Trauth B C; Klas C; Peters A M; Matzku S; Möller P; Falk W; Debatin K M; Krammer P H
Monoclonal antibody-mediated tumor regression by induction of apoptosis.
Science (New York, N.Y.) 1989;245(4915):301-5.

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