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Karen DeBell

Research Profile

Chemicals & Drugs

Phenomena

Phosphorylation

Anatomy

Concepts & Ideas

src Homology Domains

Physiology

Signal Transduction

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Publications

TOP 3
Karen E DeBell; Laurie Graham; Ilona G Reischl; Carmen Serrano; Ezio Bonvini; Barbara L Rellahan
Intramolecular regulation of phospholipase C-gamma1 by its C-terminal Src homology 2 domain.
Carmen J Serrano; Laurie Graham; Karen E DeBell; ravi rawat; Maria-Concetta Veri; Ezio Bonvini; Barbara L Rellahan; Ilona G Reischl
A new tyrosine phosphorylation site in PLC gamma 1: the role of tyrosine 775 in immune receptor signaling.
Barbara L Rellahan; Laurie J Graham; Alexander Y Tysgankov; Karen E DeBell; Maria-Concetta Veri; Cristiana Noviello; Ezio Bonvini
A dynamic constitutive and inducible binding of c-Cbl by PLCgamma1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCgamma1 activation in lymphocytes.

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All Publications

2007: Karen E DeBell; Laurie Graham; Ilona G Reischl; Carmen Serrano; Ezio Bonvini; Barbara L Rellahan
Intramolecular regulation of phospholipase C-gamma1 by its C-terminal Src homology 2 domain.
Molecular and cellular biology 2007;27(3):854-63.
2005: Carmen J Serrano; Laurie Graham; Karen E DeBell; ravi rawat; Maria-Concetta Veri; Ezio Bonvini; Barbara L Rellahan; Ilona G Reischl
A new tyrosine phosphorylation site in PLC gamma 1: the role of tyrosine 775 in immune receptor signaling.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6233-7.
2003: Barbara L Rellahan; Laurie J Graham; Alexander Y Tysgankov; Karen E DeBell; Maria-Concetta Veri; Cristiana Noviello; Ezio Bonvini
A dynamic constitutive and inducible binding of c-Cbl by PLCgamma1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCgamma1 activation in lymphocytes.
Experimental cell research 2003;289(1):184-94.
2003: Laurie J Graham; Maria-Concetta Verí; Karen E DeBell; Cristiana Noviello; ravi rawat; Sandy Jen; Ezio Bonvini; Barbara L Rellahan
70Z/3 Cbl induces PLC gamma 1 activation in T lymphocytes via an alternate Lat- and Slp-76-independent signaling mechanism.
Oncogene 2003;22(16):2493-503.
2003: Ezio Bonvini; Karen E DeBell; Maria-Concetta Verí; Laurie Graham; Bogdan A Stoica; Jorge Laborda; M Javad Aman; Angela DiBaldassarre; Sebastiano Miscia; Barbara L Rellahan
On the mechanism coupling phospholipase Cgamma1 to the B- and T-cell antigen receptors.
Advances in enzyme regulation 2003;43():245-69.
2001: Maria-Concetta Verí; Karen E DeBell; Maria-Cristina Seminario; A DiBaldassarre; Ilona G Reischl; ravi rawat; Laurie Graham; Cristiana Noviello; Barbara L Rellahan; Sebastiano Miscia; Ronald L Wange; Ezio Bonvini
Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes.
Molecular and cellular biology 2001;21(20):6939-50.
2000: Laurie J Graham; Karen E DeBell; Maria-Concetta Verí; Bogdan A Stoica; Howard Mostowski; Ezio Bonvini; Barbara L Rellahan
Differential effects of Cbl and 70Z/3 Cbl on T cell receptor-induced phospholipase Cgamma-1 activity.
FEBS letters 2000;470(3):273-80.
1999: Karen E DeBell; Bogdan A Stoica; Maria-Concetta Verí; Angela Di Baldassarre; Sebastiano Miscia; Laurie J Graham; Barbara L Rellahan; M Ishiai; T Kurosaki; Ezio Bonvini
Functional independence and interdependence of the Src homology domains of phospholipase C-gamma1 in B-cell receptor signal transduction.
Molecular and cellular biology 1999;19(11):7388-98.
1998: Laurie J Graham; Bogdan A Stoica; M Shapiro; Karen E DeBell; Barbara L Rellahan; Jorge Laborda; Ezio Bonvini
Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl.
Biochemical and biophysical research communications 1998;249(2):537-41.
1998: Bogdan A Stoica; Karen E DeBell; Laurie Graham; Barbara L Rellahan; M A Alava; Jorge Laborda; Ezio Bonvini
The amino-terminal Src homology 2 domain of phospholipase C gamma 1 is essential for TCR-induced tyrosine phosphorylation of phospholipase C gamma 1.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(3):1059-66.
1997: Barbara L Rellahan; Laurie J Graham; Bogdan A Stoica; Karen E DeBell; Ezio Bonvini
Cbl-mediated regulation of T cell receptor-induced AP1 activation. Implications for activation via the Ras signaling pathway.
The Journal of biological chemistry 1997;272(49):30806-11.
1993: A Conti; C Brando; Karen E DeBell; M A Alava; T Hoffman; Ezio Bonvini
CD3-induced preferential hydrolysis of polyphosphoinositides and calcium regulation of inositol phosphate metabolism in a permeabilized murine T cell clone.
The Journal of biological chemistry 1993;268(2):783-91.
1992: Karen E DeBell; A Conti; M A Alava; T Hoffman; Ezio Bonvini
Microfilament assembly modulates phospholipase C-mediated signal transduction by the TCR/CD3 in murine T helper lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(7):2271-80.
1992: M A Alava; Karen E DeBell; A Conti; T Hoffman; Ezio Bonvini
Increased intracellular cyclic AMP inhibits inositol phospholipid hydrolysis induced by perturbation of the T cell receptor/CD3 complex but not by G-protein stimulation. Association with protein kinase A-mediated phosphorylation of phospholipase C-gamma 1.
The Biochemical journal 1992;284 ( Pt 1)():189-99.
1991: Ezio Bonvini; Karen E DeBell; M S Taplits; C Brando; A Laurenza; K Seamon; T Hoffman
A role for guanine-nucleotide-binding proteins in mediating T-cell-receptor coupling to inositol phospholipid hydrolysis in a murine T-helper (type II) lymphocyte clone.
The Biochemical journal 1991;275 ( Pt 3)():689-96.
1990: M Ponzoni; Karen E DeBell; T Hoffman; Ezio Bonvini
Differential changes in lipid metabolism of myeloid and lymphoid cell lines induced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA).
FEBS letters 1990;276(1-2):25-8.
1990: Karen E DeBell; M S Taplits; T Hoffman; Ezio Bonvini
T lymphocyte aggregation with immobilized anti-TCR-antibodies is dependent upon energy and microfilament assembly.
Cellular immunology 1990;127(1):159-71.
1989: Ezio Bonvini; Karen E DeBell; Michael A Kolber; T Hoffman; Richard J Hodes; M S Taplits
Hydrolysis of inositol phospholipids induced by stimulation of the T cell antigen receptor complex in antigen-specific, murine helper T cell clones. Requirement for exogenous calcium.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(2):587-95.