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Charles Deber
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15
Rath, Arianna
11
Melnyk, Roman
11
Partridge, Anthony
10
Liu, Li-Ping
9
Therien, Alex
6
Johnson, Rachel
6
Burrows, Lori
5
Fraser, Paul
4
Chan, Celine
4
Glukhov, Evgenia
4
woolley, andrew
3
Stark, Margareta
3
Kim, Sanguk
3
Bowie, James
2
Bear, Christine
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All Publications
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2009: Cheung Joanne C; Kim Chiaw Patrick; Deber Charles M; Bear Christine E
A novel method for monitoring the cytosolic delivery of peptide cargo.
Journal of controlled release : official journal of the Controlled Release Society 2009;137(1):2-7.
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2009: Rath Arianna; Tulumello David V; Deber Charles M
Peptide models of membrane protein folding.
Biochemistry 2009;48(14):3036-45.
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2009: Poulsen Bradley E; Rath Arianna; Deber Charles M
The assembly motif of a bacterial small multidrug resistance protein.
The Journal of biological chemistry 2009;284(15):9870-5.
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2009: Rath Arianna; Glibowicka Mira; Nadeau Vincent G; Chen Gong; Deber Charles M
Detergent binding explains anomalous SDS-PAGE migration of membrane proteins.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):1760-5.
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2009: Cunningham Fiona; Rath Arianna; Johnson Rachel M; Deber Charles M
Distinctions between hydrophobic helices in globular proteins and transmembrane segments as factors in protein sorting.
The Journal of biological chemistry 2009;284(8):5395-402.
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2009: Cunningham Fiona; Rath Arianna; Deber Charles M
Hydrophobic peptide segments in soluble proteins competent for membrane insertion: role in amyloidogenesis.
Advances in experimental medicine and biology 2009;611():299-300.
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2008: Gierasch Lila M; Deber Charles M; Brodsky Barbara
Celebrating the scientific legacy of Elkan R. Blout.
Biopolymers 2008;89(5):323.
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2008: Glukhov Evgenia; Burrows Lori L; Deber Charles M
Membrane interactions of designed cationic antimicrobial peptides: the two thresholds.
Biopolymers 2008;89(5):360-71.
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2008: Cheung Joanne C; Deber Charles M
Misfolding of the cystic fibrosis transmembrane conductance regulator and disease.
Biochemistry 2008;47(6):1465-73.
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2008: Rath Arianna; Deber Charles M
Surface recognition elements of membrane protein oligomerization.
Proteins 2008;70(3):786-93.
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2008: Deber Charles M; Cheung Joanne C; Rath Arianna
Defining the defect in F508 del CFTR: a soluble problem?
Chemistry & biology 2008;15(1):3-4.
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2008: Wehbi Hania; Gasmi-Seabrook Geneviève; Choi Mei Y; Deber Charles M
Positional dependence of non-native polar mutations on folding of CFTR helical hairpins.
Biochimica et biophysica acta 2008;1778(1):79-87.
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2007: Plotkowski Megan L; Kim Sanguk; Phillips Martin L; Partridge Anthony W; Deber Charles M; Bowie James U
Transmembrane domain of myelin protein zero can form dimers: possible implications for myelin construction.
Biochemistry 2007;46(43):12164-73.
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2007: Glukhov Evgenia; Shulga Yulia V; Epand Raquel F; Dicu Armela O; Topham Matthew K; Deber Charles M; Epand Richard M
Membrane interactions of the hydrophobic segment of diacylglycerol kinase epsilon.
Biochimica et biophysica acta 2007;1768(10):2549-58.
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2007: Johnson Rachel M; Hecht Karen; Deber Charles M
Aromatic and cation-pi interactions enhance helix-helix association in a membrane environment.
Biochemistry 2007;46(32):9208-14.
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2007: Kuo Hsin H; Chan Celine; Burrows Lori L; Deber Charles M
Hydrophobic interactions in complexes of antimicrobial peptides with bacterial polysaccharides.
Chemical biology & drug design 2007;69(6):405-12.
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2007: Wehbi Hania; Rath Arianna; Glibowicka Mira; Deber Charles M
Role of the extracellular loop in the folding of a CFTR transmembrane helical hairpin.
Biochemistry 2007;46(24):7099-106.
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2007: Cunningham Fiona; Deber Charles M
Optimizing synthesis and expression of transmembrane peptides and proteins.
Methods (San Diego, Calif.) 2007;41(4):370-80.
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2007: Rath Arianna; Deber Charles M
Membrane protein assembly patterns reflect selection for non-proliferative structures.
FEBS letters 2007;581(7):1335-41.
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2007: Rath Arianna; Johnson Rachel M; Deber Charles M
Peptides as transmembrane segments: decrypting the determinants for helix-helix interactions in membrane proteins.
Biopolymers 2007;88(2):217-32.
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2006: Johnson Rachel M; Rath Arianna; Deber Charles M
The position of the Gly-xxx-Gly motif in transmembrane segments modulates dimer affinity.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2006;84(6):1006-12.
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2006: Wellhauser Leigh; Kuo Hsin-Hen; Stratford Fiona L L; Ramjeesingh Mohabir; Huan Ling-Jun; Luong Winnie; Li Canhui; Deber Charles M; Bear Christine E
Nucleotides bind to the C-terminus of ClC-5.
The Biochemical journal 2006;398(2):289-94.
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2006: Johnson Rachel M; Rath Arianna; Melnyk Roman A; Deber Charles M
Lipid solvation effects contribute to the affinity of Gly-xxx-Gly motif-mediated helix-helix interactions.
Biochemistry 2006;45(28):8507-15.
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2006: Go Mandy Y; Kim Sanguk; Partridge Anthony W; Melnyk Roman A; Rath Arianna; Deber Charles M; Mogridge Jeremy
Self-association of the transmembrane domain of an anthrax toxin receptor.
Journal of molecular biology 2006;360(1):145-56.
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2006: Rath Arianna; Melnyk Roman A; Deber Charles M
Evidence for assembly of small multidrug resistance proteins by a "two-faced" transmembrane helix.
The Journal of biological chemistry 2006;281(22):15546-53.
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2006: Burrows Lori L; Stark Margareta; Chan Celine; Glukhov Evgenia; Sinnadurai Selva; Deber Charles M
Activity of novel non-amphipathic cationic antimicrobial peptides against Candida species.
The Journal of antimicrobial chemotherapy 2006;57(5):899-907.
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2005: Glukhov Evgenia; Stark Margareta; Burrows Lori L; Deber Charles M
Basis for selectivity of cationic antimicrobial peptides for bacterial versus mammalian membranes.
The Journal of biological chemistry 2005;280(40):33960-7.
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2005: Chan C; Burrows L L; Deber C M
Alginate as an auxiliary bacterial membrane: binding of membrane-active peptides by polysaccharides.
The journal of peptide research : official journal of the American Peptide Society 2005;65(3):343-51.
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2005: Choi Mei Y; Partridge Anthony W; Daniels Craig; Du Kai; Lukacs Gergely L; Deber Charles M
Destabilization of the transmembrane domain induces misfolding in a phenotypic mutant of cystic fibrosis transmembrane conductance regulator.
The Journal of biological chemistry 2005;280(6):4968-74.
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2005: Rath Arianna; Davidson Alan R; Deber Charles M
The structure of "unstructured" regions in peptides and proteins: role of the polyproline II helix in protein folding and recognition.
Biopolymers 2005;80(2-3):179-85.
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2004: Johnson Rachel M; Heslop Claire L; Deber Charles M
Hydrophobic helical hairpins: design and packing interactions in membrane environments.
Biochemistry 2004;43(45):14361-9.
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2004: Chan Celine; Burrows Lori L; Deber Charles M
Helix induction in antimicrobial peptides by alginate in biofilms.
The Journal of biological chemistry 2004;279(37):38749-54.
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2004: Choi Mei Y; Cardarelli Lia; Therien Alex G; Deber Charles M
Non-native interhelical hydrogen bonds in the cystic fibrosis transmembrane conductance regulator domain modulated by polar mutations.
Biochemistry 2004;43(25):8077-83.
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2004: Melnyk Roman A; Kim Sanguk; Curran A Rachael; Engelman Donald M; Bowie James U; Deber Charles M
The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication.
The Journal of biological chemistry 2004;279(16):16591-7.
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2004: Partridge Anthony W; Therien Alex G; Deber Charles M
Missense mutations in transmembrane domains of proteins: phenotypic propensity of polar residues for human disease.
Proteins 2004;54(4):648-56.
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2004: Tang Yan-Chun; Deber Charles M
Aqueous solubility and membrane interactions of hydrophobic peptides with peptoid tags.
Biopolymers 2004;76(2):110-8.
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2003: George Susan R; Ng Gordon Y K; Lee Samuel P; Fan Theresa; Varghese George; Wang Chen; Deber Charles M; Seeman Philip; O'Dowd Brian F
Blockade of G protein-coupled receptors and the dopamine transporter by a transmembrane domain peptide: novel strategy for functional inhibition of membrane proteins in vivo.
The Journal of pharmacology and experimental therapeutics 2003;307(2):481-9.
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2003: Zouzoulas Athina; Therien Alex G; Scanzano Rosemarie; Deber Charles M; Blostein Rhoda
Modulation of Na,K-ATPase by the gamma subunit: studies with transfected cells and transmembrane mimetic peptides.
The Journal of biological chemistry 2003;278(42):40437-41.
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2003: Dawson Jessica P; Melnyk Roman A; Deber Charles M; Engelman Donald M
Sequence context strongly modulates association of polar residues in transmembrane helices.
Journal of molecular biology 2003;331(1):255-62.
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2003: Partridge Anthony W; Melnyk Roman A; Yang Dawn; Bowie James U; Deber Charles M
A transmembrane segment mimic derived from Escherichia coli diacylglycerol kinase inhibits protein activity.
The Journal of biological chemistry 2003;278(24):22056-60.
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2003: Abdalla Salma A; Cymerman Urszula; Johnson Rachel M; Deber Charles M; Letarte Michelle
Disease-associated mutations in conserved residues of ALK-1 kinase domain.
European journal of human genetics : EJHG 2003;11(4):279-87.
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2003: Melnyk Roman A; Partridge Anthony W; Yip Jeannie; Wu Yanqiu; Goto Natalie K; Deber Charles M
Polar residue tagging of transmembrane peptides.
Biopolymers 2003;71(6):675-85.
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2003: Maeda Mitsuko; Melnyk Roman A; Partridge Anthony W; Liu Li-Ping; Deber Charles M
Transmembrane segment peptides with double D-amino acid replacements: helicity, hydrophobicity, and antimicrobial activity.
Biopolymers 2003;71(1):77-84.
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2002: Stark Margareta; Liu Li-Ping; Deber Charles M
Cationic hydrophobic peptides with antimicrobial activity.
Antimicrobial agents and chemotherapy 2002;46(11):3585-90.
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2002: Tang Yan-Chun; Deber Charles M
Hydrophobicity and helicity of membrane-interactive peptides containing peptoid residues.
Biopolymers 2002;65(4):254-62.
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2002: Therien Alex G; Deber Charles M
Oligomerization of a peptide derived from the transmembrane region of the sodium pump gamma subunit: effect of the pathological mutation G41R.
Journal of molecular biology 2002;322(3):583-50.
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2002: Therien Alex G; Glibowicka Mira; Deber Charles M
Expression and purification of two hydrophobic double-spanning membrane proteins derived from the cystic fibrosis transmembrane conductance regulator.
Protein expression and purification 2002;25(1):81-6.
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2002: Deber Charles M; Therien Alex G
Putting the beta-breaks on membrane protein misfolding.
Nature structural biology 2002;9(5):318-9.
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2002: Partridge Anthony W; Melnyk Roman A; Deber Charles M
Polar residues in membrane domains of proteins: molecular basis for helix-helix association in a mutant CFTR transmembrane segment.
Biochemistry 2002;41(11):3647-53.
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2002: Therien Alex G; Deber Charles M
Interhelical packing in detergent micelles. Folding of a cystic fibrosis transmembrane conductance regulator construct.
The Journal of biological chemistry 2002;277(8):6067-72.
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2002: Melnyk Roman A; Partridge Anthony W; Deber Charles M
Transmembrane domain mediated self-assembly of major coat protein subunits from Ff bacteriophage.
Journal of molecular biology 2002;315(1):63-72.
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2002: Partridge Anthony W; Therien Alex G; Deber Charles M
Polar mutations in membrane proteins as a biophysical basis for disease.
Biopolymers 2002;66(5):350-8.
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2001: Melnyk R A; Partridge A W; Deber C M
Retention of native-like oligomerization states in transmembrane segment peptides: application to the Escherichia coli aspartate receptor.
Biochemistry 2001;40(37):11106-13.
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2001: Therien A G; Grant F E; Deber C M
Interhelical hydrogen bonds in the CFTR membrane domain.
Nature structural biology 2001;8(7):597-601.
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2001: Deber C M; Wang C; Liu L P; Prior A S; Agrawal S; Muskat B L; Cuticchia A J
TM Finder: a prediction program for transmembrane protein segments using a combination of hydrophobicity and nonpolar phase helicity scales.
Protein science : a publication of the Protein Society 2001;10(1):212-9.
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2000: Yuen C T; Davidson A R; Deber C M
Role of aromatic residues at the lipid-water interface in micelle-bound bacteriophage M13 major coat protein.
Biochemistry 2000;39(51):16155-62.
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2000: Wang C; Deber C M
Peptide mimics of the M13 coat protein transmembrane segment. Retention of helix-helix interaction motifs.
The Journal of biological chemistry 2000;275(21):16155-9.
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1999: Pomroy N C; Deber C M
Conjugation of polyethylene glycol via a disulfide bond confers water solubility upon a peptide model of a protein transmembrane segment.
Analytical biochemistry 1999;275(2):224-30.
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1999: Deber C M; Liu L P; Wang C
Perspective: peptides as mimics of transmembrane segments in proteins.
The journal of peptide research : official journal of the American Peptide Society 1999;54(3):200-5.
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1999: Liu L P; Deber C M
Combining hydrophobicity and helicity: a novel approach to membrane protein structure prediction.
Bioorganic & medicinal chemistry 1999;7(1):1-7.
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1998: Liu L P; Deber C M
Uncoupling hydrophobicity and helicity in transmembrane segments. Alpha-helical propensities of the amino acids in non-polar environments.
The Journal of biological chemistry 1998;273(37):23645-8.
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1998: Peng S; Liu L P; Emili A Q; Deber C M
Cystic fibrosis transmembrane conductance regulator: expression and helicity of a double membrane-spanning segment.
FEBS letters 1998;431(1):29-33.
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1998: Pomroy N C; Deber C M
Solubilization of hydrophobic peptides by reversible cysteine PEGylation.
Biochemical and biophysical research communications 1998;245(2):618-21.
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1998: Liu L P; Deber C M
Guidelines for membrane protein engineering derived from de novo designed model peptides.
Biopolymers 1998;47(1):41-62.
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1997: Malaney S; Trumpower B L; Deber C M; Robinson B H
The N terminus of the Qcr7 protein of the cytochrome bc1 complex is not essential for import into mitochondria in Saccharomyces cerevisiae but is essential for assembly of the complex.
The Journal of biological chemistry 1997;272(28):17495-501.
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1997: Liu L P; Deber C M
Anionic phospholipids modulate peptide insertion into membranes.
Biochemistry 1997;36(18):5476-82.
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1996: Deber C M; Goto N K
Folding proteins into membranes.
Nature structural biology 1996;3(10):815-8.
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1996: Liu L P; Li S C; Goto N K; Deber C M
Threshold hydrophobicity dictates helical conformations of peptides in membrane environments.
Biopolymers 1996;39(3):465-70.
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1996: Williams K A; Deber C M
Biophysical characterization of wild-type and mutant bacteriophage IKe major coat protein in the virion and in detergent micelles.
Biochemistry 1996;35(32):10472-83.
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1996: Li S C; Goto N K; Williams K A; Deber C M
Alpha-helical, but not beta-sheet, propensity of proline is determined by peptide environment.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6676-81.
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1996: Williams K A; Farrow N A; Deber C M; Kay L E
Structure and dynamics of bacteriophage IKe major coat protein in MPG micelles by solution NMR.
Biochemistry 1996;35(16):5145-57.
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1995: Williams K A; Glibowicka M; Li Z; Li H; Khan A R; Chen Y M; Wang J; Marvin D A; Deber C M
Packing of coat protein amphipathic and transmembrane helices in filamentous bacteriophage M13: role of small residues in protein oligomerization.
Journal of molecular biology 1995;252(1):6-14.
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1995: Khan A R; Williams K A; Boggs J M; Deber C M
Accessibility and dynamics of Cys residues in Bacteriophage IKe and M13 major coat protein mutants.
Biochemistry 1995;34(38):12388-97.
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1995: Li S C; Kim P K; Deber C M
Manipulation of peptide conformations by fine-tuning of the environment and/or the primary sequence.
Biopolymers 1995;35(6):667-75.
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1995: Khan A R; Deber C M
An engineered disulfide bridge in the transmembrane region of phage M13 coat protein stabilizes the alpha-helical dimer.
Biochemical and biophysical research communications 1995;206(1):230-7.
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1995: Deber C M; Li S C
Peptides in membranes: helicity and hydrophobicity.
Biopolymers 1995;37(5):295-318.
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1994: Li S C; Deber C M; Shoelson S E
An irregularity in the transmembrane domain helix correlates with the rate of insulin receptor internalization.
Biochemistry 1994;33(47):14333-8.
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1994: Li S C; Deber C M
A measure of helical propensity for amino acids in membrane environments.
Nature structural biology 1994;1(6):368-73.
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1994: Pawagi A B; Wang J; Silverman M; Reithmeier R A; Deber C M
Transmembrane aromatic amino acid distribution in P-glycoprotein. A functional role in broad substrate specificity.
Journal of molecular biology 1994;235(2):554-64.
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1993: Deber C M; Khan A R; Li Z; Joensson C; Glibowicka M; Wang J
Val-->Ala mutations selectively alter helix-helix packing in the transmembrane segment of phage M13 coat protein.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11648-52.
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1993: Li S C; Deber C M
Peptide environment specifies conformation. Helicity of hydrophobic segments compared in aqueous, organic, and membrane environments.
The Journal of biological chemistry 1993;268(31):22975-8.
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1993: Williams K A; Deber C M
Mutagenesis of bacteriophage IKe major coat protein transmembrane domain: role of an interfacial proline residue.
Biochemical and biophysical research communications 1993;196(1):1-6.
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1993: Li Z; Glibowicka M; Joensson C; Deber C M
Conformational states of mutant M13 coat proteins are regulated by transmembrane residues.
The Journal of biological chemistry 1993;268(7):4584-7.
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1993: Landolt-Marticorena C; Williams K A; Deber C M; Reithmeier R A
Non-random distribution of amino acids in the transmembrane segments of human type I single span membrane proteins.
Journal of molecular biology 1993;229(3):602-8.
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1993: Williams K A; Deber C M
The structure and function of central nervous system myelin.
Critical reviews in clinical laboratory sciences 1993;30(1):29-64.
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1992: Li S C; Deber C M
Glycine and beta-branched residues support and modulate peptide helicity in membrane environments.
FEBS letters 1992;311(3):217-20.
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1992: Li S C; Deber C M
Influence of glycine residues on peptide conformation in membrane environments.
International journal of peptide and protein research 1992;40(3-4):243-8.
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1992: Deber C M; Li Z; Joensson C; Glibowicka M; Xu G Y
Transmembrane region of wild-type and mutant M13 coat proteins. Conformational role of beta-branched residues.
The Journal of biological chemistry 1992;267(8):5296-300.
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1991: Li Z; Deber C M
Viable transmembrane region mutants of bacteriophage M13 coat protein prepared by site-directed mutagenesis.
Biochemical and biophysical research communications 1991;180(2):687-93.
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1991: Williams K A; Deber C M
Proline residues in transmembrane helices: structural or dynamic role?
Biochemistry 1991;30(37):8919-23.
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1991: Xu G Y; Deber C M
Conformations of neurotensin in solution and in membrane environments studied by 2-D NMR spectroscopy.
International journal of peptide and protein research 1991;37(6):528-35.
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1991: Deber C M; Reynolds S J
Central nervous system myelin: structure, function, and pathology.
Clinical biochemistry 1991;24(2):113-34.
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1990: Deber C M; Sorrell B J; Xu G Y
Conformation of proline residues in bacteriorhodopsin.
Biochemical and biophysical research communications 1990;172(2):862-9.
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1990: Pawagi A B; Deber C M
Ligand-dependent quenching of tryptophan fluorescence in human erythrocyte hexose transport protein.
Biochemistry 1990;29(4):950-5.
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1990: Deber C M; Glibowicka M; Woolley G A
Conformations of proline residues in membrane environments.
Biopolymers 1990;29(1):149-57.
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1989: Fraser P E; Rand R P; Deber C M
Bilayer-stabilizing properties of myelin basic protein in dioleoylphosphatidylethanolamine systems.
Biochimica et biophysica acta 1989;983(1):23-9.
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1989: Deber C M; Lutek M K; Heimer E P; Felix A M
Conformational origin of a difficult coupling in a human growth hormone releasing factor analog.
Peptide research 1989;2(2):184-8.
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1989: Woolley G A; Deber C M
A lipid vesicle system for probing voltage-dependent peptide-lipid interactions: application to alamethicin channel formation.
Biopolymers 1989;28(1):267-72.
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1988: Brandl C J; Deber R B; Hsu L C; Woolley G A; Young X K; Deber C M
Evidence for similar function of transmembrane segments in receptor and membrane-anchored proteins.
Biopolymers 1988;27(7):1171-82.
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1988: Lutek M K; Hofmann T; Deber C M
Transpeptidation reactions of porcine pepsin. Formation of tetrapeptides from dipeptide substrates.
The Journal of biological chemistry 1988;263(17):8011-6.
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1987: Pawagi A B; Deber C M
D-glucose binding increases secondary structure of human erythrocyte monosaccharide transport protein.
Biochemical and biophysical research communications 1987;145(3):1087-91.
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1987: Woolley G A; Deber C M
Peptides in membranes: lipid-induced secondary structure of substance P.
Biopolymers 1987;26 Suppl():S109-21.
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1986: Fraser P E; Moscarello M A; Rand R P; Deber C M
Spontaneous vesicularization of myelin lipids is counteracted by myelin basic protein.
Biochimica et biophysica acta 1986;863(2):282-8.
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1986: Deber C M; Brandl C J; Deber R B; Hsu L C; Young X K
Amino acid composition of the membrane and aqueous domains of integral membrane proteins.
Archives of biochemistry and biophysics 1986;251(1):68-76.
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1986: Deber C M; Hughes D W; Fraser P E; Pawagi A B; Moscarello M A
Binding of human normal and multiple sclerosis-derived myelin basic protein to phospholipid vesicles: effects on membrane head group and bilayer regions.
Archives of biochemistry and biophysics 1986;245(2):455-63.
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1986: Brandl C J; Deber C M
Hypothesis about the function of membrane-buried proline residues in transport proteins.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(4):917-21.
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1985: Fraser P E; Deber C M
Structure and function of the proline-rich region of myelin basic protein.
Biochemistry 1985;24(17):4593-8.
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1984: Fraser P E; Deber C M
Surface accessibility of 13C-labeled lysine residues in membrane-bound myelin basic protein.
The Journal of biological chemistry 1984;259(14):8689-92.
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1982: Hughes D W; Stollery J G; Moscarello M A; Deber C M
Binding of myelin basic protein to phospholipid micelles.
The Journal of biological chemistry 1982;257(9):4698-700.
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1982: Hughes D W; Deber C M
Conformations of cyclic peptide/calcium complexes in solution.
Biopolymers 1982;21(1):169-79.
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1981: Boggs J M; Stamp D; Hughes D W; Deber C M
Influence of ether linkage on the lamellar to hexagonal phase transition of ethanolamine phospholipids.
Biochemistry 1981;20(20):5728-35.
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1980: Stollery J G; Boggs J M; Moscarello M A; Deber C M
Direct observation by carbon-13 nuclear magnetic resonance of membrane-bound human myelin basic protein.
Biochemistry 1980;19(11):2391-6.
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