Carl Decicco

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Cherney Robert J; Mo Ruowei; Meyer Dayton T; Voss Matthew E; Lo Yvonne C; Yang Gengjie; Miller Persymphonie B; Scherle Peggy A; Tebben Andrew J; Carter Percy H; Decicco Carl P
Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.
Cherney Robert J; Brogan John B; Mo Ruowei; Lo Yvonne C; Yang Gengjie; Miller Persymphonie B; Scherle Peggy A; Molino Bruce F; Carter Percy H; Decicco Carl P
Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.
Cherney Robert J; Nelson David J; Lo Yvonne C; Yang Gengjie; Scherle Peggy A; Jezak Heather; Solomon Kimberly A; Carter Percy H; Decicco Carl P
Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists.

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All Publications

2009: Cherney Robert J; Mo Ruowei; Meyer Dayton T; Voss Matthew E; Lo Yvonne C; Yang Gengjie; Miller Persymphonie B; Scherle Peggy A; Tebben Andrew J; Carter Percy H; Decicco Carl P
Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.
Bioorganic & medicinal chemistry letters 2009;19(13):3418-22.
2009: Cherney Robert J; Brogan John B; Mo Ruowei; Lo Yvonne C; Yang Gengjie; Miller Persymphonie B; Scherle Peggy A; Molino Bruce F; Carter Percy H; Decicco Carl P
Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.
Bioorganic & medicinal chemistry letters 2009;19(3):597-601.
2008: Cherney Robert J; Nelson David J; Lo Yvonne C; Yang Gengjie; Scherle Peggy A; Jezak Heather; Solomon Kimberly A; Carter Percy H; Decicco Carl P
Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists.
Bioorganic & medicinal chemistry letters 2008;18(18):5063-5.
2008: He Kan; Qian Mingxin; Wong Harvey; Bai Stephen A; He Bing; Brogdon Bernice; Grace James E; Xin Baomin; Wu Jingtao; Ren Shelly X; Zeng Hang; Deng Yuzhong; Graden Danielle M; Olah Timothy V; Unger Steve E; Luettgen Joseph M; Knabb Robert M; Pinto Donald J; Lam Patrick Y S; Duan James; Wexler Ruth R; Decicco Carl P; Christ David D; Grossman Scott J
N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical considerations.
Journal of pharmaceutical sciences 2008;97(7):2568-80.
2008: Garner C Edwin; Solon Eric; Lai Chii-Ming; Lin Jianrong; Luo Gang; Jones Kevin; Duan Jingwu; Decicco Carl P; Maduskuie Thomas; Mercer Stephen E; Gan Lian-Shen; Qian Mingxin; Prakash Shimoga; Shen Huey-Shin; Lee Frank W
Role of P-glycoprotein and the intestine in the excretion of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in rodents.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(6):1102-10.
2008: Cherney Robert J; Mo Ruowei; Meyer Dayton T; Nelson David J; Lo Yvonne C; Yang Gengjie; Scherle Peggy A; Mandlekar Sandhya; Wasserman Zelda R; Jezak Heather; Solomon Kimberly A; Tebben Andrew J; Carter Percy H; Decicco Carl P
Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists.
Journal of medicinal chemistry 2008;51(4):721-4.
2008: Santella Joseph B; Gardner Daniel S; Yao Wenqing; Shi Chongsheng; Reddy Prabhakar; Tebben Andrew J; DeLucca George V; Wacker Dean A; Watson Paul S; Welch Patricia K; Wadman Eric A; Davies Paul; Solomon Kimberly A; Graden Dani M; Yeleswaram Swamy; Mandlekar Sandhya; Kariv Ilona; Decicco Carl P; Ko Soo S; Carter Percy H; Duncia John V
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis.
Bioorganic & medicinal chemistry letters 2008;18(2):576-85.
2008: Ott Gregory R; Asakawa Naoyuki; Lu Zhonghui; Liu Rui-Qin; Covington Maryanne B; Vaddi Krishna; Qian Mingxin; Newton Robert C; Christ David D; Traskos James M; Decicco Carl P; Duan James J-W
Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2008;18(2):694-9.
2008: Duan James J-W; Chen Lihua; Lu Zhonghui; Xue Chu-Biao; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Wasserman Zelda R; Vaddi Krishna; Christ David D; Trzaskos James M; Newton Robert C; Decicco Carl P
Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(1):241-6.
2007: Carter Percy H; Brown Gregory D; Friedrich Sarah R; Cherney Robert J; Tebben Andrew J; Lo Yvonne C; Yang Gengjie; Jezak Heather; Solomon Kimberly A; Scherle Peggy A; Decicco Carl P
Capped diaminopropionamide-glycine dipeptides are inhibitors of CC chemokine receptor 2 (CCR2).
Bioorganic & medicinal chemistry letters 2007;17(19):5455-61.
2007: Qian Mingxin; Bai Stephen A; Brogdon Bernice; Wu Jing-Tao; Liu Rui-Qin; Covington Maryanne B; Vaddi Kris; Newton Robert C; Fossler Michael J; Garner C Edwin; Deng Yuzhong; Maduskuie Thomas; Trzaskos James; Duan James J-W; Decicco Carl P; Christ David D
Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1916-25.
2007: Pruitt James R; Batt Douglas G; Wacker Dean A; Bostrom Lori L; Booker Shon K; McLaughlin Erin; Houghton Gregory C; Varnes Jeffrey G; Christ David D; Covington Maryanne; Das Anuk M; Davies Paul; Graden Danielle; Kariv Ilona; Orlovsky Yevgeniya; Stowell Nicole C; Vaddi Krishna G; Wadman Eric A; Welch Patricia K; Yeleswaram Swamy; Solomon Kimberly A; Newton Robert C; Decicco Carl P; Carter Percy H; Ko Soo S
CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
Bioorganic & medicinal chemistry letters 2007;17(11):2992-7.
2007: Luo Gang; Garner C Edwin; Xiong Hao; Hu Hanbo; Richards Lauren E; Brouwer Kim L R; Duan Jingwu; Decicco Carl P; Maduskuie Thomas; Shen Helen; Lee Frank W; Gan Liang-Shang
Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transporter-based drug-drug interaction case study.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(6):835-40.
2007: Sheppeck James E; Gilmore John L; Tebben Andrew; Xue Chu-Biao; Liu Rui-Qin; Decicco Carl P; Duan James J-W
Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2007;17(10):2769-74.
2007: Carter Percy H; Liu Rui-Qin; Foster William R; Tamasi Joseph A; Tebben Andrew J; Favata Margaret; Staal Ada; Cvijic Mary Ellen; French Michele H; Dell Vanessa; Apanovitch Donald; Lei Ming; Zhao Qihong; Cunningham Mark; Decicco Carl P; Trzaskos James M; Feyen Jean H M
Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6846-51.
2007: Chen Xiao-Tao; Ghavimi Bahman; Corbett Ronald L; Xue Chu-Biao; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Vaddi Krishna G; Christ David D; Hartman Karl D; Ribadeneira Maria D; Trzaskos James M; Newton Robert C; Decicco Carl P; Duan James J-W
A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(7):1865-70.
2007: Sheppeck James E; Gilmore John L; Yang Anle; Chen Xiao-Tao; Xue Chu-Biao; Roderick John; Liu Rui-Qin; Covington Maryanne B; Decicco Carl P; Duan James J-W
Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2007;17(5):1413-7.
2007: Sheppeck James E; Tebben Andrew; Gilmore John L; Yang Anle; Wasserman Zelda R; Decicco Carl P; Duan James J-W
A molecular modeling analysis of novel non-hydroxamate inhibitors of TACE.
Bioorganic & medicinal chemistry letters 2007;17(5):1408-12.
2007: Duan James J-W; Chen Lihua; Lu Zhonghui; Jiang Bin; Asakawa Naoyuki; Sheppeck James E; Liu Rui-Qin; Covington Maryanne B; Pitts William; Kim Soong-Hoon; Decicco Carl P
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2007;17(1):266-71.
2006: Watson Paul S; Jiang Bin; Harrison Kim; Asakawa Nao; Welch Patricia K; Covington Maryanne; Stowell Nicole C; Wadman Eric A; Davies Paul; Solomon Kimberly A; Newton Robert C; Trainor George L; Friedman Steven M; Decicco Carl P; Ko Soo S
2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.
Bioorganic & medicinal chemistry letters 2006;16(21):5695-9.
2006: Gilmore John L; King Bryan W; Harris Cathy; Maduskuie Thomas; Mercer Stephen E; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Ribadeneria Maria D; Vaddi Krishna; Trzaskos James M; Newton Robert C; Decicco Carl P; Duan James J-W
Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(10):2699-704.
2006: Cherney Robert J; King Bryan W; Gilmore John L; Liu Rui-Qin; Covington Maryanne B; Duan James J-W; Decicco Carl P
Conversion of potent MMP inhibitors into selective TACE inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(4):1028-31.
2005: Han Wei; Jiang Xiangjun; Hu Zilun; Wasserman Zelda R; Decicco Carl P
Investigation of glycine alpha-ketoamide HCV NS3 protease inhibitors: effect of carboxylic acid isosteres.
Bioorganic & medicinal chemistry letters 2005;15(15):3487-90.
2005: Duan James J-W; Lu Zhonghui; Wasserman Zelda R; Liu Rui-Qin; Covington Maryanne B; Decicco Carl P
Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-alpha converting enzyme.
Bioorganic & medicinal chemistry letters 2005;15(12):2970-3.
2005: De Lucca George V; Kim Ui Tae; Vargo Brian J; Duncia John V; Santella Joseph B; Gardner Daniel S; Zheng Changsheng; Liauw Ann; Wang Zhang; Emmett George; Wacker Dean A; Welch Patricia K; Covington Maryanne; Stowell Nicole C; Wadman Eric A; Das Anuk M; Davies Paul; Yeleswaram Swamy; Graden Danielle M; Solomon Kimberly A; Newton Robert C; Trainor George L; Decicco Carl P; Ko Soo S
Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.
Journal of medicinal chemistry 2005;48(6):2194-211.
2005: Batt Douglas G; Houghton Gregory C; Roderick John; Santella Joseph B; Wacker Dean A; Welch Patricia K; Orlovsky Yevgeniya I; Wadman Eric A; Trzaskos James M; Davies Paul; Decicco Carl P; Carter Percy H
N-Arylalkylpiperidine urea derivatives as CC chemokine receptor-3 (CCR3) antagonists.
Bioorganic & medicinal chemistry letters 2005;15(3):787-91.
2004: Xue Chu-Biao; Chen Xiao-Tao; He Xiaohua; Roderick John; Corbett Ronald L; Ghavimi Bahman; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Ribadeneira Maria D; Vaddi Krishna; Trzaskos James; Newton Robert C; Duan James J-W; Decicco Carl P
Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(17):4453-9.
2004: Cherney Robert J; Mo Ruowei; Meyer Dayton T; Hardman Karl D; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Wasserman Zelda R; Christ David D; Trzaskos James M; Newton Robert C; Decicco Carl P
Sultam hydroxamates as novel matrix metalloproteinase inhibitors.
Journal of medicinal chemistry 2004;47(12):2981-3.
2004: Wang Xinkang; Feuerstein Giora Z; Xu Lin; Wang Hugh; Schumacher William A; Ogletree Martin L; Taub Rebecca; Duan James J-W; Decicco Carl P; Liu Rui-Qin
Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats.
Molecular pharmacology 2004;65(4):890-6.
2004: Varnes Jeffrey G; Gardner Daniel S; Santella Joseph B; Duncia John V; Estrella Melissa; Watson Paul S; Clark Cheryl M; Ko Soo S; Welch Patricia; Covington Maryanne; Stowell Nicole; Wadman Eric; Davies Paul; Solomon Kimberley; Newton Robert C; Trainor George L; Decicco Carl P; Wacker Dean A
Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists.
Bioorganic & medicinal chemistry letters 2004;14(7):1645-9.
2003: Xue Chu-Biao; He Xiaohua; Roderick John; Corbett Ronald L; Duan James J-W; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Ribadeneira Maria D; Vaddi Krishna; Christ David D; Newton Robert C; Trzaskos James M; Magolda Ronald L; Wexler Ruth R; Decicco Carl P
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization.
Bioorganic & medicinal chemistry letters 2003;13(24):4299-304.
2003: Xue Chu-Biao; He Xiaohua; Roderick John; Corbett Ronald L; Duan James J-W; Liu Rui-Qin; Covington Maryanne B; Newton Robert C; Trzaskos James M; Magolda Ronald L; Wexler Ruth R; Decicco Carl P
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 1: lead identification.
Bioorganic & medicinal chemistry letters 2003;13(24):4293-7.
2003: Pratta Michael A; Yao Wenqing; Decicco Carl; Tortorella Micky D; Liu Riu-Qin; Copeland Robert A; Magolda Ronald; Newton Robert C; Trzaskos James M; Arner Elizabeth C
Aggrecan protects cartilage collagen from proteolytic cleavage.
The Journal of biological chemistry 2003;278(46):45539-45.
2003: Duan James J-W; Lu Zhonghui; Xue Chu-Biao; He Xiaohua; Seng Jennifer L; Roderick John J; Wasserman Zelda R; Liu Rui-Qin; Covington Maryanne B; Magolda Ronald L; Newton Robert C; Trzaskos James M; Decicco Carl P
Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2003;13(12):2035-40.
2003: Cherney Robert J; Duan James J-W; Voss Matthew E; Chen Lihua; Wang Li; Meyer Dayton T; Wasserman Zelda R; Hardman Karl D; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Mandlekar Sandhya; Christ David D; Trzaskos James M; Newton Robert C; Magolda Ronald L; Wexler Ruth R; Decicco Carl P
Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.
Journal of medicinal chemistry 2003;46(10):1811-23.
2003: Cherney Robert J; Mo Ruowei; Meyer Dayton T; Wang Li; Yao Wenqing; Wasserman Zelda R; Liu Rui-Qin; Covington Maryanne B; Tortorella Micky D; Arner Elizabeth C; Qian Mingxin; Christ David D; Trzaskos James M; Newton Robert C; Magolda Ron L; Decicco Carl P
Potent and selective aggrecanase inhibitors containing cyclic P1 substituents.
Bioorganic & medicinal chemistry letters 2003;13(7):1297-300.
2003: Carter Percy H; LaPorte Jacob R; Scherle Peggy A; Decicco Carl P
A new synthesis of cytoxazone and its diastereomers provides key initial SAR information.
Bioorganic & medicinal chemistry letters 2003;13(7):1237-9.
2003: Wasserman Zelda R; Duan James J-W; Voss Matthew E; Xue Chu Biao; Cherney Robert J; Nelson David J; Hardman Karl D; Decicco Carl P
Identification of a selectivity determinant for inhibition of tumor necrosis factor-alpha converting enzyme by comparative modeling.
Chemistry & biology 2003;10(3):215-23.
2003: Zhang Xiaojun; Schmitt Aaron C; Jiang Wen; Wasserman Zelda; Decicco Carl P
Design and synthesis of potent, non-peptide inhibitors of HCV NS3 protease.
Bioorganic & medicinal chemistry letters 2003;13(6):1157-60.
2003: Han Wei; Hu Zilun; Jiang Xiangjun; Wasserman Zelda R; Decicco Carl P
Glycine alpha-ketoamides as HCV NS3 protease inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(6):1111-4.
2003: Glunz Peter W; Douty Brent D; Decicco Carl P
Design and synthesis of bicyclic pyrimidinone-based HCV NS3 protease inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(5):785-8.
2003: Voss Matthew E; Carter Percy H; Tebben Andrew J; Scherle Peggy A; Brown Gregory D; Thompson Lorin A; Xu Meizhong; Lo Yvonne C; Yang Gengjie; Liu Rui-Qin; Strzemienski Paul; Everlof J Gerry; Trzaskos James M; Decicco Carl P
Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonists.
Bioorganic & medicinal chemistry letters 2003;13(3):533-8.
2002: Duan James J-W; Chen Lihua; Wasserman Zelda R; Lu Zhonghui; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Hardman Karl D; Magolda Ronald L; Newton Robert C; Christ David D; Wexler Ruth R; Decicco Carl P
Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.
Journal of medicinal chemistry 2002;45(23):4954-7.
2002: Priestley E Scott; De Lucca Indawati; Ghavimi Bahman; Erickson-Viitanen Susan; Decicco Carl P
P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease.
Bioorganic & medicinal chemistry letters 2002;12(21):3199-202.
2002: De Lucca George V; Kim Ui T; Johnson Curt; Vargo Brian J; Welch Patricia K; Covington Maryanne; Davies Paul; Solomon Kimberly A; Newton Robert C; Trainor George L; Decicco Carl P; Ko Soo S
Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists.
Journal of medicinal chemistry 2002;45(17):3794-804.
2002: Organ Michael G; Buon Christophe; Decicco Carl P; Combs Andrew P
A concise synthesis of silanediol-based transition-state isostere inhibitors of proteases.
Organic letters 2002;4(16):2683-5.
2002: Wacker Dean A; Santella Joseph B; Gardner Daniel S; Varnes Jeffrey G; Estrella Melissa; DeLucca George V; Ko Soo S; Tanabe Keiichi; Watson Paul S; Welch Patricia K; Covington Maryanne; Stowell Nicole C; Wadman Eric A; Davies Paul; Solomon Kimberly A; Newton Robert C; Trainor George L; Friedman Steven M; Decicco Carl P; Duncia John V
CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.
Bioorganic & medicinal chemistry letters 2002;12(13):1785-9.
2002: Harpel Mark R; Horiuchi Kurumi Y; Luo Ying; Shen Li; Jiang Wenjun; Nelson David J; Rogers Kelley C; Decicco Carl P; Copeland Robert A
Mutagenesis and mechanism-based inhibition of Streptococcus pyogenes Glu-tRNAGln amidotransferase implicate a serine-based glutaminase site.
Biochemistry 2002;41(20):6398-407.
2002: Xue Chu-Biao; He Xiaohua; Roderick John; Corbett Ronald L; Decicco Carl P
Asymmetric synthesis of trans-2,3-piperidinedicarboxylic acid and trans-3,4-piperidinedicarboxylic acid derivatives.
The Journal of organic chemistry 2002;67(3):865-70.
2002: Yao Wenqing; Chao Michael; Wasserman Zelda R; Liu Rui Qin; Covington Maryanne B; Newton Robert; Christ David; Wexler Ruth R; Decicco Carl P
Potent P1' biphenylmethyl substituted aggrecanase inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(1):101-4.
2001: Newton R C; Solomon K A; Covington M B; Decicco C P; Haley P J; Friedman S M; Vaddi K
Biology of TACE inhibition.
Annals of the rheumatic diseases 2001;60 Suppl 3():iii25-32.
2001: Carter P H; Scherle P A; Muckelbauer J K; Voss M E; Liu R Q; Thompson L A; Tebben A J; Solomon K A; Lo Y C; Li Z; Strzemienski P; Yang G; Falahatpisheh N; Xu M; Wu Z; Farrow N A; Ramnarayan K; Wang J; Rideout D; Yalamoori V; Domaille P; Underwood D J; Trzaskos J M; Friedman S M; Newton R C; Decicco C P;
Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):11879-84.
2001: Xue C B; He X; Corbett R L; Roderick J; Wasserman Z R; Liu R Q; Jaffee B D; Covington M B; Qian M; Trzaskos J M; Newton R C; Magolda R L; Wexler R R; Decicco C P
Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release.
Journal of medicinal chemistry 2001;44(21):3351-4.
2001: Yao W; Wasserman Z R; Chao M; Reddy G; Shi E; Liu R Q; Covington M B; Arner E C; Pratta M A; Tortorella M; Magolda R L; Newton R; Qian M; Ribadeneira M D; Christ D; Wexler R R; Decicco C P
Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.
Journal of medicinal chemistry 2001;44(21):3347-50.
2001: Decicco C P; Nelson D J; Luo Y; Shen L; Horiuchi K Y; Amsler K M; Foster L A; Spitz S M; Merrill J J; Sizemore C F; Rogers K C; Copeland R A; Harpel M R
Glutamyl-gamma-boronate inhibitors of bacterial Glu-tRNA(Gln) amidotransferase.
Bioorganic & medicinal chemistry letters 2001;11(18):2561-4.
2001: Xue C B; Voss M E; Nelson D J; Duan J J; Cherney R J; Jacobson I C; He X; Roderick J; Chen L; Corbett R L; Wang L; Meyer D T; Kennedy K; DeGradodagger W F; Hardman K D; Teleha C A; Jaffee B D; Liu R Q; Copeland R A; Covington M B; Christ D D; Trzaskos J M; Newton R C; Magolda R L; Wexler R R; Decicco C P
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Journal of medicinal chemistry 2001;44(16):2636-60.
2000: Priestley E S; Decicco C P
1-Aminocyclopropaneboronic acid: synthesis and incorporation into an inhibitor of hepatitis C virus NS3 protease.
Organic letters 2000;2(20):3095-7.
2000: Han W; Hu Z; Jiang X; Decicco C P
Alpha-ketoamides, alpha-ketoesters and alpha-diketones as HCV NS3 protease inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(8):711-3.
1999: Abbaszade I; Liu R Q; Yang F; Rosenfeld S A; Ross O H; Link J R; Ellis D M; Tortorella M D; Pratta M A; Hollis J M; Wynn R; Duke J L; George H J; Hillman M C; Murphy K; Wiswall B H; Copeland R A; Decicco C P; Bruckner R; Nagase H; Itoh Y; Newton R C; Magolda R L; Trzaskos J M; Burn T C
Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.
The Journal of biological chemistry 1999;274(33):23443-50.
1999: Newton R C; Decicco C P
Therapeutic potential and strategies for inhibiting tumor necrosis factor-alpha.
Journal of medicinal chemistry 1999;42(13):2295-314.
1999: Arner E C; Pratta M A; Decicco C P; Xue C B; Newton R C; Trzaskos J M; Magolda R L; Tortorella M D
Aggrecanase. A target for the design of inhibitors of cartilage degradation.
Annals of the New York Academy of Sciences 1999;878():92-107.
1999: Tortorella M D; Burn T C; Pratta M A; Abbaszade I; Hollis J M; Liu R; Rosenfeld S A; Copeland R A; Decicco C P; Wynn R; Rockwell A; Yang F; Duke J L; Solomon K; George H; Bruckner R; Nagase H; Itoh Y; Ellis D M; Ross H; Wiswall B H; Murphy K; Hillman M C; Hollis G F; Newton R C; Magolda R L; Trzaskos J M; Arner E C
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
Science (New York, N.Y.) 1999;284(5420):1664-6.
1999: Duan J J; Chen L; Xue C B; Wasserman Z R; Hardman K D; Covington M B; Copeland R R; Arner E C; Decicco C P
P1, P2'-linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(10):1453-8.
1999: Cherney R J; Wang L; Meyer D T; Xue C B; Arner E C; Copeland R A; Covington M B; Hardman K D; Wasserman Z R; Jaffee B D; Decicco C P
Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-alpha production.
Bioorganic & medicinal chemistry letters 1999;9(9):1279-84.
1999: Arner E C; Pratta M A; Trzaskos J M; Decicco C P; Tortorella M D
Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity.
The Journal of biological chemistry 1999;274(10):6594-601.
1998: Arner E C; Hughes C E; Decicco C P; Caterson B; Tortorella M D
Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(3):214-28.
1998: Cherney R J; Wang L; Meyer D T; Xue C B; Wasserman Z R; Hardman K D; Welch P K; Covington M B; Copeland R A; Arner E C; DeGrado W F; Decicco C P
Macrocyclic amino carboxylates as selective MMP-8 inhibitors.
Journal of medicinal chemistry 1998;41(11):1749-51.
1998: Xue C B; He X; Roderick J; DeGrado W F; Cherney R J; Hardman K D; Nelson D J; Copeland R A; Jaffee B D; Decicco C P
Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production.
Journal of medicinal chemistry 1998;41(11):1745-8.
1998: Jacobson I C; Reddy P G; Wasserman Z R; Hardman K D; Covington M B; Arner E C; Copeland R A; Decicco C P; Magolda R L
Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 1998;8(7):837-42.
1997: Solomon K A; Covington M B; DeCicco C P; Newton R C
The fate of pro-TNF-alpha following inhibition of metalloprotease-dependent processing to soluble TNF-alpha in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4524-31.
1997: Arner E C; Decicco C P; Cherney R; Tortorella M D
Cleavage of native cartilage aggrecan by neutrophil collagenase (MMP-8) is distinct from endogenous cleavage by aggrecanase.
The Journal of biological chemistry 1997;272(14):9294-9.

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