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Carl Decicco

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TOP 3
Robert J Cherney; Mary Ellen Cvijic; Carl P Decicco; Michael A Guaciaro; Yvonne C Lo; Dayton T Meyer; Persymphonie B Miller; Ruowei Mo; Anthony D Pechulis; Peggy A Scherle; Gengjie Yang; Qihong Zhao; Joel C Barrish; Percy H Carter
Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.
Percy H Carter; Robert J Cherney; Gregory D Brown; Sarah R King; Yvonne C Lo; Sandhya Mandlekar; Persymphonie B Miller; Peggy A Scherle; Andrew J Tebben; Matthew E Voss; Gengjie Yang; Qihong Zhao; Carl P Decicco
Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone.
Lorin A Thompson; Jeremy H Toyn; George L Trainor; Changsheng Zheng; Jovita Marcinkeviciene; Jere E Meredith; Jodi K Muckelbauer; Richard E Olson; Jianliang Shi; Andrew J Tebben; Charles F Albright; Donna M Barten; Kenneth M Boy; Catherine R Burton; Daniel M Camac; Andrew P Combs; Robert A Copeland; Carl P Decicco; Andrew C Good; James E Grace; Jason M Guernon; Kimberley A Lentz; Ann Liauw; John E Macor
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.

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All Publications

2012: Robert J Cherney; Mary Ellen Cvijic; Carl P Decicco; Michael A Guaciaro; Yvonne C Lo; Dayton T Meyer; Persymphonie B Miller; Ruowei Mo; Anthony D Pechulis; Peggy A Scherle; Gengjie Yang; Qihong Zhao; Joel C Barrish; Percy H Carter
Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.
Bioorganic & medicinal chemistry letters 2012;22(19):6181-4.
2012: Percy H Carter; Robert J Cherney; Gregory D Brown; Sarah R King; Yvonne C Lo; Sandhya Mandlekar; Persymphonie B Miller; Peggy A Scherle; Andrew J Tebben; Matthew E Voss; Gengjie Yang; Qihong Zhao; Carl P Decicco
Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone.
Bioorganic & medicinal chemistry letters 2012;22(9):3311-6.
2011: Lorin A Thompson; Jeremy H Toyn; George L Trainor; Changsheng Zheng; Jovita Marcinkeviciene; Jere E Meredith; Jodi K Muckelbauer; Richard E Olson; Jianliang Shi; Andrew J Tebben; Charles F Albright; Donna M Barten; Kenneth M Boy; Catherine R Burton; Daniel M Camac; Andrew P Combs; Robert A Copeland; Carl P Decicco; Andrew C Good; James E Grace; Jason M Guernon; Kimberley A Lentz; Ann Liauw; John E Macor
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(22):6909-15.
2010: Robert J Cherney; Ruowei Mo; Dayton T Meyer; Matthew E Voss; Michael G Yang; Joseph B Santella; John V Duncia; Yvonne C Lo; Gengjie Yang; Persymphonie B Miller; Peggy A Scherle; Qihong Zhao; Sandhya Mandlekar; Mary Ellen Cvijic; Joel C Barrish; Carl P Decicco; Percy H Carter
gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.
Bioorganic & medicinal chemistry letters 2010;20(8):2425-30.
2009: Robert J Cherney; Ruowei Mo; Dayton T Meyer; Matthew E Voss; Yvonne C Lo; Gengjie Yang; Persymphonie B Miller; Peggy A Scherle; Andrew J Tebben; Percy H Carter; Carl P Decicco
Novel sulfone-containing di- and trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.
Bioorganic & medicinal chemistry letters 2009;19(13):3418-22.
2009: Robert J Cherney; John B Brogan; Ruowei Mo; Yvonne C Lo; Gengjie Yang; Persymphonie B Miller; Peggy A Scherle; Bruce F Molino; Percy H Carter; Carl P Decicco
Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.
Bioorganic & medicinal chemistry letters 2009;19(3):597-601.
2008: Robert J Cherney; David J Nelson; Yvonne C Lo; Gengjie Yang; Peggy A Scherle; Heather Jezak; Kimberly A Solomon; Percy H Carter; Carl P Decicco
Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists.
Bioorganic & medicinal chemistry letters 2008;18(18):5063-5.
2008: Kan He; Mingxin Qian; Harvey Wong; Stephen A Bai; Bing He; Bernice Brogdon; James E Grace; Baomin Xin; Jingtao Wu; Shelly X Ren; Hang Zeng; Yuzhong Deng; Danielle M Graden; Timothy V Olah; Steve E Unger; Joseph M Luettgen; Robert M Knabb; Donald J Pinto; Patrick Y S Lam; James Duan; Ruth R Wexler; Carl P Decicco; David D Christ; Scott J Grossman
N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical considerations.
Journal of pharmaceutical sciences 2008;97(7):2568-80.
2008: C Edwin Garner; Eric Solon; Chii-Ming Lai; Jianrong Lin; Gang Luo; Kevin Jones; Jingwu Duan; Carl P Decicco; Thomas Maduskuie; Stephen E Mercer; Lian-Shen Gan; Mingxin Qian; Shimoga Prakash; Huey-Shin Shen; Frank W Lee
Role of P-glycoprotein and the intestine in the excretion of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in rodents.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(6):1102-10.
2008: Robert J Cherney; Ruowei Mo; Dayton T Meyer; David J Nelson; Yvonne C Lo; Gengjie Yang; Peggy A Scherle; Sandhya Mandlekar; Zelda R Wasserman; Heather Jezak; Kimberly A Solomon; Andrew J Tebben; Percy H Carter; Carl P Decicco
Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists.
Journal of medicinal chemistry 2008;51(4):721-4.
2008: Joseph B Santella; Daniel S Gardner; Wenqing Yao; Chongsheng Shi; Prabhakar Reddy; Andrew J Tebben; George V DeLucca; Dean A Wacker; Paul S Watson; Patricia K Welch; Eric A Wadman; Paul Davies; Kimberly A Solomon; Danielle Graden; Swamy Yeleswaram; Sandhya Mandlekar; Ilona Kariv; Carl P Decicco; Soo S Ko; Percy H Carter; John V Duncia
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis.
Bioorganic & medicinal chemistry letters 2008;18(2):576-85.
2008: Gregory R Ott; Naoyuki Asakawa; Zhonghui Lu; Rui-Qin Liu; Maryanne B Covington; Kris Vaddi; Mingxin Qian; Robert C Newton; David D Christ; James M Traskos; Carl P Decicco; James J-W Duan
Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2008;18(2):694-9.
2008: James J-W Duan; Lihua Chen; Zhonghui Lu; Chu-Biao Xue; Rui-Qin Liu; Maryanne B Covington; Mingxin Qian; Zelda R Wasserman; Kris Vaddi; David D Christ; James M Trzaskos; Robert C Newton; Carl P Decicco
Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(1):241-6.
2007: Percy H Carter; Gregory D Brown; Sarah R Friedrich; Robert J Cherney; Andrew J Tebben; Yvonne C Lo; Gengjie Yang; Heather Jezak; Kimberly A Solomon; Peggy A Scherle; Carl P Decicco
Capped diaminopropionamide-glycine dipeptides are inhibitors of CC chemokine receptor 2 (CCR2).
Bioorganic & medicinal chemistry letters 2007;17(19):5455-61.
2007: Mingxin Qian; Stephen A Bai; Bernice Brogdon; Jing-Tao Wu; Rui-Qin Liu; Maryanne B Covington; Kris Vaddi; Robert C Newton; Michael Fossler; C Edwin Garner; Yuzhong Deng; Thomas Maduskuie; James M Trzaskos; James J-W Duan; Carl P Decicco; David D Christ
Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1916-25.
2007: James R Pruitt; Douglas G Batt; Dean A Wacker; Lori L Bostrom; Shon K Booker; Erin McLaughlin; Gregory C Houghton; Jeffrey G Varnes; David D Christ; Maryanne B Covington; Anuk M Das; Paul Davies; Danielle Graden; Ilona Kariv; Yevgeniya Orlovsky; Nicole C Stowell; Kris Vaddi; Eric A Wadman; Patricia K Welch; Swamy Yeleswaram; Kimberly A Solomon; Robert C Newton; Carl P Decicco; Percy H Carter; Soo S Ko
CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
Bioorganic & medicinal chemistry letters 2007;17(11):2992-7.
2007: Gang Luo; C Edwin Garner; Hao Xiong; Hanbo Hu; Lauren E Richards; Kim L R Brouwer; Jingwu Duan; Carl P Decicco; Thomas Maduskuie; Helen Shen; Frank W Lee; Liang-Shang Gan
Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transporter-based drug-drug interaction case study.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(6):835-40.
2007: James E Sheppeck; John L Gilmore; Andrew J Tebben; Chu-Biao Xue; Rui-Qin Liu; Carl P Decicco; James J-W Duan
Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2007;17(10):2769-74.
2007: Percy H Carter; Rui-Qin Liu; William R Foster; Joseph Tamasi; Andrew J Tebben; Margaret F Favata; Ada Staal; Mary Ellen Cvijic; Michele H French; Vanessa Dell; Donald Apanovitch; Ming Lei; Qihong Zhao; Mark Cunningham; Carl P Decicco; James M Trzaskos; Jean H M Feyen
Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6846-51.
2007: Xiao-Tao Chen; Bahman Ghavimi; Ronald L Corbett; Chu-Biao Xue; Rui-Qin Liu; Maryanne B Covington; Mingxin Qian; Kris Vaddi; David D Christ; Karl D Hartman; Maria D Ribadeneira; James M Trzaskos; Robert C Newton; Carl P Decicco; James J-W Duan
A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(7):1865-70.
2007: James E Sheppeck; John L Gilmore; Anle Yang; Xiao-Tao Chen; Chu-Biao Xue; John Roderick; Rui-Qin Liu; Maryanne B Covington; Carl P Decicco; James J-W Duan
Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2007;17(5):1413-7.
2007: James E Sheppeck; Andrew J Tebben; John L Gilmore; Anle Yang; Zelda R Wasserman; Carl P Decicco; James J-W Duan
A molecular modeling analysis of novel non-hydroxamate inhibitors of TACE.
Bioorganic & medicinal chemistry letters 2007;17(5):1408-12.
2007: James J-W Duan; Lihua Chen; Zhonghui Lu; Bin Jiang; Naoyuki Asakawa; James E Sheppeck; Rui-Qin Liu; Maryanne B Covington; William Pitts; Soong-Hoon Kim; Carl P Decicco
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2007;17(1):266-71.
2006: Paul S Watson; Bin Jiang; Kim Harrison; Naoyuki Asakawa; Patricia K Welch; Maryanne B Covington; Nicole C Stowell; Eric A Wadman; Paul Davies; Kimberly A Solomon; Robert C Newton; George L Trainor; Steven M Friedman; Carl P Decicco; Soo S Ko
2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.
Bioorganic & medicinal chemistry letters 2006;16(21):5695-9.
2006: John L Gilmore; Bryan W King; Cathy Harris; Thomas Maduskuie; Stephen E Mercer; Rui-Qin Liu; Maryanne B Covington; Mingxin Qian; Maria D Ribadeneria; Kris Vaddi; James M Trzaskos; Robert C Newton; Carl P Decicco; James J-W Duan
Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(10):2699-704.
2006: Robert J Cherney; Bryan W King; John L Gilmore; Rui-Qin Liu; Maryanne B Covington; James J-W Duan; Carl P Decicco
Conversion of potent MMP inhibitors into selective TACE inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(4):1028-31.
2005: Wei Han; Xiangjun Jiang; Zilun Hu; Zelda R Wasserman; Carl P Decicco
Investigation of glycine alpha-ketoamide HCV NS3 protease inhibitors: effect of carboxylic acid isosteres.
Bioorganic & medicinal chemistry letters 2005;15(15):3487-90.
2005: James J-W Duan; Zhonghui Lu; Zelda R Wasserman; Rui-Qin Liu; Maryanne B Covington; Carl P Decicco
Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-alpha converting enzyme.
Bioorganic & medicinal chemistry letters 2005;15(12):2970-3.
2005: George V De Lucca; Ui Tae Kim; Brian J Vargo; John V Duncia; Joseph B Santella; Daniel S Gardner; Changsheng Zheng; Ann Y Liauw; Zhang Wang; George Emmett; Dean A Wacker; Patricia K Welch; Maryanne B Covington; Nicole C Stowell; Eric A Wadman; Anuk M Das; Paul Davies; Swamy Yeleswaram; Danielle Graden; Kimberly A Solomon; Robert C Newton; George L Trainor; Carl P Decicco; Soo S Ko
Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.
Journal of medicinal chemistry 2005;48(6):2194-211.
2005: Douglas G Batt; Gregory C Houghton; John Roderick; Joseph B Santella; Dean A Wacker; Patricia K Welch; Yevgeniya I Orlovsky; Eric A Wadman; James M Trzaskos; Paul Davies; Carl P Decicco; Percy H Carter
N-Arylalkylpiperidine urea derivatives as CC chemokine receptor-3 (CCR3) antagonists.
Bioorganic & medicinal chemistry letters 2005;15(3):787-91.
2004: Chu-Biao Xue; Xiao-Tao Chen; Xiaohua He; John Roderick; Ronald L Corbett; Bahman Ghavimi; Rui-Qin Liu; Maryanne B Covington; Mingxin Qian; Maria D Ribadeneira; Kris Vaddi; James M Trzaskos; Robert C Newton; James J-W Duan; Carl P Decicco
Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(17):4453-9.
2004: Robert J Cherney; Ruowei Mo; Dayton T Meyer; Karl D Hardman; Rui-Qin Liu; Maryanne B Covington; Mingxin Qian; Zelda R Wasserman; David D Christ; James M Trzaskos; Robert C Newton; Carl P Decicco
Sultam hydroxamates as novel matrix metalloproteinase inhibitors.
Journal of medicinal chemistry 2004;47(12):2981-3.
2004: Jeffrey G Varnes; Daniel S Gardner; Joseph B Santella; John V Duncia; Melissa Estrella; Paul S Watson; Cheryl M Clark; Soo S Ko; Patricia K Welch; Maryanne B Covington; Nicole C Stowell; Eric A Wadman; Paul Davies; Kimberley Solomon; Robert C Newton; George L Trainor; Carl P Decicco; Dean A Wacker
Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists.
Bioorganic & medicinal chemistry letters 2004;14(7):1645-9.
2004: Xinkang Wang; Giora Z Feuerstein; Lin Xu; Hugh Wang; William A Schumacher; Martin Ogletree; Rebecca Taub; James J-W Duan; Carl P Decicco; Rui-Qin Liu
Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats.
Molecular pharmacology 2004;65(4):890-6.
2003: Chu-Biao Xue; Xiaohua He; John Roderick; Ronald L Corbett; James J-W Duan; Rui-Qin Liu; Maryanne B Covington; Mingxin Qian; Maria D Ribadeneira; Kris Vaddi; David D Christ; Robert C Newton; James M Trzaskos; Ronald L Magolda; Ruth R Wexler; Carl P Decicco
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization.
Bioorganic & medicinal chemistry letters 2003;13(24):4299-304.
2003: Chu-Biao Xue; Xiaohua He; John Roderick; Ronald L Corbett; James J-W Duan; Rui-Qin Liu; Maryanne B Covington; Robert C Newton; James M Trzaskos; Ronald L Magolda; Ruth R Wexler; Carl P Decicco
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 1: lead identification.
Bioorganic & medicinal chemistry letters 2003;13(24):4293-7.
2003: Michael A Pratta; Wenqing Yao; Carl P Decicco; Micky D Tortorella; Rui-Qin Liu; Robert Copeland; Ronald L Magolda; Robert C Newton; James M Trzaskos; Elizabeth C Arner
Aggrecan protects cartilage collagen from proteolytic cleavage.
The Journal of biological chemistry 2003;278(46):45539-45.
2003: James J-W Duan; Zhonghui Lu; Chu-Biao Xue; Xiaohua He; Jennifer L Seng; John Roderick; Zelda R Wasserman; Rui-Qin Liu; Maryanne B Covington; Ronald L Magolda; Robert C Newton; James M Trzaskos; Carl P Decicco
Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2003;13(12):2035-40.
2003: Robert J Cherney; James J-W Duan; Matthew E Voss; Lihua Chen; Li Wang; Dayton T Meyer; Zelda R Wasserman; Karl D Hardman; Rui-Qin Liu; Maryanne B Covington; Mingxin Qian; Sandhya Mandlekar; David D Christ; James M Trzaskos; Robert C Newton; Ronald L Magolda; Ruth R Wexler; Carl P Decicco
Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.
Journal of medicinal chemistry 2003;46(10):1811-23.
2003: Robert J Cherney; Ruowei Mo; Dayton T Meyer; Li Wang; Wenqing Yao; Zelda R Wasserman; Rui-Qin Liu; Maryanne B Covington; Micky D Tortorella; Elizabeth C Arner; Mingxin Qian; David D Christ; James M Trzaskos; Robert C Newton; Ronald L Magolda; Carl P Decicco
Potent and selective aggrecanase inhibitors containing cyclic P1 substituents.
Bioorganic & medicinal chemistry letters 2003;13(7):1297-300.
2003: Percy H Carter; Jacob R LaPorte; Peggy A Scherle; Carl P Decicco
A new synthesis of cytoxazone and its diastereomers provides key initial SAR information.
Bioorganic & medicinal chemistry letters 2003;13(7):1237-9.
2003: Xiaojun Zhang; Aaron C Schmitt; Wen Jiang; Zelda R Wasserman; Carl P Decicco
Design and synthesis of potent, non-peptide inhibitors of HCV NS3 protease.
Bioorganic & medicinal chemistry letters 2003;13(6):1157-60.
2003: Wei Han; Zilun Hu; Xiangjun Jiang; Zelda R Wasserman; Carl P Decicco
Glycine alpha-ketoamides as HCV NS3 protease inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(6):1111-4.
2003: Peter W Glunz; Brent D Douty; Carl P Decicco
Design and synthesis of bicyclic pyrimidinone-based HCV NS3 protease inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(5):785-8.
2003: Zelda R Wasserman; James J-W Duan; Matthew E Voss; Chu-Biao Xue; Robert J Cherney; David J Nelson; Karl D Hardman; Carl P Decicco
Identification of a selectivity determinant for inhibition of tumor necrosis factor-alpha converting enzyme by comparative modeling.
Chemistry & biology 2003;10(3):215-23.
2003: Matthew E Voss; Percy H Carter; Andrew J Tebben; Peggy A Scherle; Gregory D Brown; Lorin A Thompson; Meizhong Xu; Yvonne C Lo; Gengjie Yang; Rui-Qin Liu; Paul Strzemienski; J Gerry Everlof; James M Trzaskos; Carl P Decicco
Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonists.
Bioorganic & medicinal chemistry letters 2003;13(3):533-8.
2002: James J-W Duan; Lihua Chen; Zelda R Wasserman; Zhonghui Lu; Rui-Qin Liu; Maryanne B Covington; Mingxin Qian; Karl D Hardman; Ronald L Magolda; Robert C Newton; David D Christ; Ruth R Wexler; Carl P Decicco
Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.
Journal of medicinal chemistry 2002;45(23):4954-7.
2002: E Scott Priestley; Indawati De Lucca; Bahman Ghavimi; Susan Erickson-Viitanen; Carl P Decicco
P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease.
Bioorganic & medicinal chemistry letters 2002;12(21):3199-202.
2002: George V De Lucca; Ui Tae Kim; Curt Johnson; Brian J Vargo; Patricia K Welch; Maryanne B Covington; Paul Davies; Kimberly A Solomon; Robert C Newton; George L Trainor; Carl P Decicco; Soo S Ko
Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists.
Journal of medicinal chemistry 2002;45(17):3794-804.
2002: Michael G Organ; Christophe Buon; Carl P Decicco; Andrew P Combs
A concise synthesis of silanediol-based transition-state isostere inhibitors of proteases.
Organic letters 2002;4(16):2683-5.
2002: Dean A Wacker; Joseph B Santella; Daniel S Gardner; Jeffrey G Varnes; Melissa Estrella; George V DeLucca; Soo S Ko; Keiichi Tanabe; Paul S Watson; Patricia K Welch; Maryanne B Covington; Nicole C Stowell; Eric A Wadman; Paul Davies; Kimberly A Solomon; Robert C Newton; George L Trainor; Steven M Friedman; Carl P Decicco; John V Duncia
CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.
Bioorganic & medicinal chemistry letters 2002;12(13):1785-9.
2002: Mark R Harpel; Kurumi Y Horiuchi; Ying Luo; Li Shen; Wenjun Jiang; David J Nelson; Kelley C Rogers; Carl P Decicco; Robert Copeland
Mutagenesis and mechanism-based inhibition of Streptococcus pyogenes Glu-tRNAGln amidotransferase implicate a serine-based glutaminase site.
Biochemistry 2002;41(20):6398-407.
2002: Chu-Biao Xue; Xiaohua He; John Roderick; Ronald L Corbett; Carl P Decicco
Asymmetric synthesis of trans-2,3-piperidinedicarboxylic acid and trans-3,4-piperidinedicarboxylic acid derivatives.
The Journal of organic chemistry 2002;67(3):865-70.
2002: Wenqing Yao; Michael Chao; Zelda R Wasserman; Rui-Qin Liu; Maryanne B Covington; Robert Newton; David D Christ; Ruth R Wexler; Carl P Decicco
Potent P1' biphenylmethyl substituted aggrecanase inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(1):101-4.
2001: Robert C Newton; Kimberly A Solomon; Maryanne B Covington; Carl P Decicco; P J Haley; Steven M Friedman; Kris Vaddi
Biology of TACE inhibition.
Annals of the rheumatic diseases 2001;60 Suppl 3():iii25-32.
2001: Chu-Biao Xue; Xiaohua He; Ronald L Corbett; John Roderick; Zelda R Wasserman; Rui-Qin Liu; BD Jaffee; Maryanne B Covington; Mingxin Qian; James M Trzaskos; Robert C Newton; Ronald L Magolda; Ruth R Wexler; Carl P Decicco
Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release.
Journal of medicinal chemistry 2001;44(21):3351-4.
2001: W Yao; Zelda R Wasserman; M Chao; G Reddy; E Shi; Rui-Qin Liu; Maryanne B Covington; Elizabeth C Arner; Michael A Pratta; Micky D Tortorella; Ronald L Magolda; R Newton; Mingxin Qian; Maria D Ribadeneira; David D Christ; Ruth R Wexler; Carl P Decicco
Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.
Journal of medicinal chemistry 2001;44(21):3347-50.
2001: Percy H Carter; Peggy A Scherle; J K Muckelbauer; Matthew E Voss; Rui-Qin Liu; Lorin A Thompson; Andrew J Tebben; Kimberly A Solomon; Yvonne C Lo; Z Li; P Strzemienski; Gengjie Yang; N Falahatpisheh; M Xu; Z Wu; N A Farrow; Kalyanaraman Ramnarayan; J Wang; D Rideout; V Yalamoori; Peter J Domaille; D J Underwood; James M Trzaskos; Steven M Friedman; Robert C Newton; Carl P Decicco; J A Muckelbauer
Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):11879-84.
2001: Carl P Decicco; D J Nelson; Ying Luo; Li Shen; Kurumi Y Horiuchi; Karen M Amsler; Lorie A Foster; Susan M Spitz; Jayson J Merrill; Christine F Sizemore; Kelley C Rogers; Robert Copeland; Mark R Harpel
Glutamyl-gamma-boronate inhibitors of bacterial Glu-tRNA(Gln) amidotransferase.
Bioorganic & medicinal chemistry letters 2001;11(18):2561-4.
2001: Chu-Biao Xue; Matthew E Voss; David J Nelson; James J-W Duan; Robert J Cherney; Irina C Jacobson; Xiaohua He; John Roderick; Lihua Chen; Ronald L Corbett; Li Wang; Dayton T Meyer; K Kennedy; W F DeGradodagger; Karl D Hardman; Christopher A Teleha; BD Jaffee; Rui-Qin Liu; Robert Copeland; Maryanne B Covington; David D Christ; James M Trzaskos; Robert C Newton; Ronald L Magolda; Ruth R Wexler; Carl P Decicco
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Journal of medicinal chemistry 2001;44(16):2636-60.
2000: E Scott Priestley; Carl P Decicco
1-Aminocyclopropaneboronic acid: synthesis and incorporation into an inhibitor of hepatitis C virus NS3 protease.
Organic letters 2000;2(20):3095-7.
2000: W Han; Z Hu; X Jiang; Carl P Decicco
Alpha-ketoamides, alpha-ketoesters and alpha-diketones as HCV NS3 protease inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(8):711-3.
1999: I Abbaszade; Rui-Qin Liu; F Yang; SA Rosenfeld; OH Ross; John R Link; D M Ellis; Micky D Tortorella; Michael A Pratta; JM Hollis; Richard Wynn; JL Duke; Henry J George; Milton C Hillman; KATHLEEN MURPHY; BH Wiswall; Robert Copeland; Carl P Decicco; Robert Bruckner; H Nagase; Y Itoh; Robert C Newton; Ronald L Magolda; James M Trzaskos; Timothy C Burn
Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.
The Journal of biological chemistry 1999;274(33):23443-50.
1999: Robert C Newton; Carl P Decicco
Therapeutic potential and strategies for inhibiting tumor necrosis factor-alpha.
Journal of medicinal chemistry 1999;42(13):2295-314.
1999: Elizabeth C Arner; Michael A Pratta; Carl P Decicco; Chu-Biao Xue; Robert C Newton; James M Trzaskos; Ronald L Magolda; Micky D Tortorella
Aggrecanase. A target for the design of inhibitors of cartilage degradation.
Annals of the New York Academy of Sciences 1999;878():92-107.
1999: Micky D Tortorella; Timothy C Burn; Michael A Pratta; I Abbaszade; JM Hollis; R Liu; SA Rosenfeld; Robert Copeland; Carl P Decicco; Richard Wynn; A Rockwell; F Yang; JL Duke; Kimberley Solomon; Henry J George; Robert Bruckner; H Nagase; Y Itoh; D M Ellis; H Ross; BH Wiswall; KATHLEEN MURPHY; Milton C Hillman; Gregory F Hollis; Robert C Newton; Ronald L Magolda; James M Trzaskos; Elizabeth C Arner
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
Science (New York, N.Y.) 1999;284(5420):1664-6.
1999: James J-W Duan; Lihua Chen; Chu-Biao Xue; Zelda R Wasserman; Karl D Hardman; Maryanne B Covington; R R Copeland; Elizabeth C Arner; Carl P Decicco
P1, P2'-linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(10):1453-8.
1999: Robert J Cherney; Li Wang; Dayton T Meyer; Chu-Biao Xue; Elizabeth C Arner; Robert Copeland; Maryanne B Covington; Karl D Hardman; Zelda R Wasserman; BD Jaffee; Carl P Decicco
Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-alpha production.
Bioorganic & medicinal chemistry letters 1999;9(9):1279-84.
1999: Elizabeth C Arner; Michael A Pratta; James M Trzaskos; Carl P Decicco; Micky D Tortorella
Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity.
The Journal of biological chemistry 1999;274(10):6594-601.
1998: Robert J Cherney; Li Wang; Dayton T Meyer; Chu-Biao Xue; Zelda R Wasserman; Karl D Hardman; P K Welch; Maryanne B Covington; Robert Copeland; Elizabeth C Arner; WF DeGrado; Carl P Decicco
Macrocyclic amino carboxylates as selective MMP-8 inhibitors.
Journal of medicinal chemistry 1998;41(11):1749-51.
1998: Chu-Biao Xue; Xiaohua He; John Roderick; WF DeGrado; Robert J Cherney; Karl D Hardman; David J Nelson; Robert Copeland; BD Jaffee; Carl P Decicco
Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production.
Journal of medicinal chemistry 1998;41(11):1745-8.
1998: Elizabeth C Arner; C E Hughes; Carl P Decicco; B Caterson; Micky D Tortorella
Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(3):214-28.
1998: Irina C Jacobson; P G Reddy; Zelda R Wasserman; Karl D Hardman; Maryanne B Covington; Elizabeth C Arner; Robert Copeland; Carl P Decicco; Ronald L Magolda
Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 1998;8(7):837-42.
1997: Kimberly A Solomon; Maryanne B Covington; Carl P Decicco; Robert C Newton
The fate of pro-TNF-alpha following inhibition of metalloprotease-dependent processing to soluble TNF-alpha in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4524-31.
1997: Elizabeth C Arner; Carl P Decicco; Robert J Cherney; Micky D Tortorella
Cleavage of native cartilage aggrecan by neutrophil collagenase (MMP-8) is distinct from endogenous cleavage by aggrecanase.
The Journal of biological chemistry 1997;272(14):9294-9.