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Romano Deghenghi

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Chemicals & Drugs

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Anatomy

Pituitary Gland

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Valeria Sibilia; Giampiero Muccioli; Romano Deghenghi; Francesca Pagani; V De Luca; Daniela Rapetti; Vittorio Locatelli; Carmela Netti
Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat.
Paola Cassoni; Corrado Ghé; Tiziana Marrocco; Elena Tarabra; Elena Allia; Filomena Catapano; Romano Deghenghi; Ezio Ghigo; Mauro Papotti; Giampiero Muccioli
Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines.
Salvatora Succu; Maria Stefania Mascia; Tiziana Melis; Maria Rosaria Melis; Romano Deghenghi; Antonio Argiolas
Activation of GABAA and opioid receptors reduce penile erection induced by hexarelin peptides.

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All Publications

2006: Valeria Sibilia; Giampiero Muccioli; Romano Deghenghi; Francesca Pagani; V De Luca; Daniela Rapetti; Vittorio Locatelli; Carmela Netti
Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat.
Journal of neuroendocrinology 2006;18(2):122-8.
2004: Paola Cassoni; Corrado Ghé; Tiziana Marrocco; Elena Tarabra; Elena Allia; Filomena Catapano; Romano Deghenghi; Ezio Ghigo; Mauro Papotti; Giampiero Muccioli
Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines.
European journal of endocrinology / European Federation of Endocrine Societies 2004;150(2):173-84.
2003: Salvatora Succu; Maria Stefania Mascia; Tiziana Melis; Maria Rosaria Melis; Romano Deghenghi; Antonio Argiolas
Activation of GABAA and opioid receptors reduce penile erection induced by hexarelin peptides.
Pharmacology, biochemistry, and behavior 2003;76(3-4):563-70.
2003: Romano Deghenghi; Fabio Broglio; Mauro Papotti; Giampiero Muccioli; Ezio Ghigo
Targeting the ghrelin receptor: orally active GHS and cortistatin analogs.
Endocrine 2003;22(1):13-8.
2003: Laura Gianotti; Johannes D Veldhuis; Silvia Destefanis; Fabio Lanfranco; Josefina Ramunni; Emanuela Arvat; M Marzetto; François Boutignon; Romano Deghenghi; Ezio Ghigo
Suppression and recovery of LH secretion by a potent and selective GnRH-receptor antagonist peptide in healthy early follicular-phase women are mediated via selective control of LH secretory burst mass.
Clinical endocrinology 2003;59(4):526-32.
2003: Fabio Broglio; Cristina Gottero; Andrea Benso; Flavia Prodam; Silvia Destefanis; Carlotta Gauna; Mauro Maccario; Romano Deghenghi; Aart Jan Van der Lely; Ezio Ghigo
Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans.
The Journal of clinical endocrinology and metabolism 2003;88(9):4268-72.
2003: Ivano Bedendi; Giuseppe Alloatti; andrea marcantoni; Daniela Malan; Filomena Catapano; Corrado Ghé; Romano Deghenghi; Ezio Ghigo; Giampiero Muccioli
Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin.
European journal of pharmacology 2003;476(1-2):87-95.
2003: Delphine Mallardé; François Boutignon; Fabien Moine; Edith Barré; Sandrine David; Hélène Touchet; Paolo Ferruti; Romano Deghenghi
PLGA-PEG microspheres of teverelix: influence of polymer type on microsphere characteristics and on teverelix in vitro release.
International journal of pharmaceutics 2003;261(1-2):69-80.
2003: Mauro Papotti; Elena Tarabra; Elena Allia; Francesca Bozzalla-Cassione; Fabio Broglio; Romano Deghenghi; Ezio Ghigo; Giampiero Muccioli
Presence of cortistatin in the human pancreas.
Journal of endocrinological investigation 2003;26(8):RC15-8.
2003: Andrea Benso; Cristina Gottero; Flavia Prodam; Carlotta Gauna; Silvia Destefanis; L Filtri; Aart Jan Van der Lely; Romano Deghenghi; Ezio Ghigo; Fabio Broglio
Effects of cortistatin-14 and somatostatin-14 on the endocrine response to hexarelin in humans.
Journal of endocrinological investigation 2003;26(7):599-603.
2003: Antonio Torsello; Elena Bresciani; Giuseppe Rossoni; Roberta Avallone; Giovanni Tulipano; Daniela Cocchi; Ilaria Bulgarelli; Romano Deghenghi; Ferruccio Berti; Vittorio Locatelli
Ghrelin plays a minor role in the physiological control of cardiac function in the rat.
Endocrinology 2003;144(5):1787-92.
2003: Fabio Broglio; Andrea Benso; Carlotta Castiglioni; Cristina Gottero; Flavia Prodam; Silvia Destefanis; Carlotta Gauna; Aart Jan Van der Lely; Romano Deghenghi; Mario Bo; Emanuela Arvat; Ezio Ghigo
The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects.
The Journal of clinical endocrinology and metabolism 2003;88(4):1537-42.
2003: Vincent Guerlavais; Damien Boeglin; Delphine Mousseaux; Catherine Oiry; Annie Heitz; Romano Deghenghi; Vittorio Locatelli; Antonio Torsello; Corrado Ghé; Filomena Catapano; Giampiero Muccioli; Jean-Claude Galleyrand; Jean-Alain Fehrentz; Jean Martinez
New active series of growth hormone secretagogues.
Journal of medicinal chemistry 2003;46(7):1191-203.
2003: Fabio Broglio; Andrea Benso; Cristina Gottero; Flavia Prodam; Carlotta Gauna; L Filtri; Emanuela Arvat; Aart Jan Van der Lely; Romano Deghenghi; Ezio Ghigo
Non-acylated ghrelin does not possess the pituitaric and pancreatic endocrine activity of acylated ghrelin in humans.
Journal of endocrinological investigation 2003;26(3):192-6.
2003: Fabio Broglio; Emanuela Arvat; Cristina Gottero; Andrea Benso; Flavia Prodam; Silvia Destefanis; Gianluca Aimaretti; Mauro Papotti; Giampiero Muccioli; Romano Deghenghi; Ezio Ghigo
Natural and synthetic growth hormone secretagogues: do they have therapeutic potential?
Treatments in endocrinology 2003;2(3):153-63.
2003: Fabio Broglio; Cristina Gottero; Andrea Benso; Flavia Prodam; Felipe F Casanueva; Carlos Dieguez; Aart Jan Van der Lely; Romano Deghenghi; Emanuela Arvat; Ezio Ghigo
Acetylcholine does not play a major role in mediating the endocrine responses to ghrelin, a natural ligand of the GH secretagogue receptor, in humans.
Clinical endocrinology 2003;58(1):92-8.
2003: Valeria Sibilia; Guido Rindi; Francesca Pagani; Daniela Rapetti; Vittorio Locatelli; Antonio Torsello; Nicoletta Campanini; Romano Deghenghi; Carmela Netti
Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action.
Endocrinology 2003;144(1):353-9.
2002: Gianluca Baldanzi; Nicoletta Filigheddu; Santina Cutrupi; Filomena Catapano; Sara Bonissoni; Alberto Fubini; Daniela Malan; Germano Baj; Riccarda Granata; Fabio Broglio; Mauro Papotti; Nicola Surico; Federico Bussolino; Jörgen Isgaard; Romano Deghenghi; Fabiola Sinigaglia; Maria Prat; Giampiero Muccioli; Ezio Ghigo; Andrea Graziani
Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT.
The Journal of cell biology 2002;159(6):1029-37.
2002: Alfonso Leal-Cerro; Elena Torres; Alfonso Soto; Elena Dios; Romano Deghenghi; Emanuela Arvat; Ezio Ghigo; Carlos Dieguez; Felipe F Casanueva
Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses.
Neuroendocrinology 2002;76(6):390-6.
2002: Fabio Broglio; Emanuela Arvat; Andrea Benso; Mauro Papotti; Giampiero Muccioli; Romano Deghenghi; Ezio Ghigo
Ghrelin: endocrine and non-endocrine actions.
Journal of pediatric endocrinology & metabolism : JPEM 2002;15 Suppl 5():1219-27.
2002: Dragan Micic; Djuro Macut; Mirjana Sumarac-Dumanovic; Aleksandra Kendereski; Vera Popovic; Romano Deghenghi; Carlos Dieguez; Felipe F Casanueva
Ghrelin-induced GH secretion in normal subjects is partially resistant to homologous desensitization by GH-releasing peptide-6.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(6):761-6.
2002: I Pettersson; Giampiero Muccioli; Riccarda Granata; Romano Deghenghi; E Ghigo; Claes Ohlsson; Jörgen Isgaard
Natural (ghrelin) and synthetic (hexarelin) GH secretagogues stimulate H9c2 cardiomyocyte cell proliferation.
The Journal of endocrinology 2002;175(1):201-9.
2002: Fabio Broglio; Peter van Koetsveld Pv; Andrea Benso; Cristina Gottero; Flavia Prodam; Mauro Papotti; Giampiero Muccioli; Carlotta Gauna; Leo J Hofland; Romano Deghenghi; Emanuela Arvat; Aart Jan Van der Lely; Ezio Ghigo
Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans.
The Journal of clinical endocrinology and metabolism 2002;87(10):4829-32.
2002: Maria Rosaria Melis; Maria Stefania Mascia; Salvatora Succu; Antonio Torsello; Eugenio E Muller; Romano Deghenghi; Antonio Argiolas
Ghrelin injected into the paraventricular nucleus of the hypothalamus of male rats induces feeding but not penile erection.
Neuroscience letters 2002;329(3):339-43.
2002: Emanuela Arvat; Fabio Broglio; Gianluca Aimaretti; Andrea Benso; Roberta Giordano; Romano Deghenghi; Ezio Ghigo
Ghrelin and synthetic GH secretagogues.
Best practice & research. Clinical endocrinology & metabolism 2002;16(3):505-17.
2002: Fabio Broglio; François Boutignon; Andrea Benso; Cristina Gottero; Flavia Prodam; Emanuela Arvat; Corrado Ghè; Filomena Catapano; Antonio Torsello; Vittorio Locatelli; Giampiero Muccioli; Damien Boeglin; Vincent Guerlavais; Jean-Alain Fehrentz; Jean Martinez; Ezio Ghigo; Romano Deghenghi
EP1572: a novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man.
Journal of endocrinological investigation 2002;25(8):RC26-8.
2002: Jean-Alain Fehrentz; Jean Martinez; Damien Boeglin; Vincent Guerlavais; Romano Deghenghi
Growth hormone secretagogues: past, present and future.
IDrugs : the investigational drugs journal 2002;5(8):804-14.
2002: Fabio Broglio; Emanuela Arvat; Andrea Benso; Cristina Gottero; Flavia Prodam; Riccarda Granata; Mauro Papotti; Giampiero Muccioli; Romano Deghenghi; Ezio Ghigo
Ghrelin: much more than a natural growth hormone secretagogue.
The Israel Medical Association journal : IMAJ 2002;4(8):607-13.
2002: Fabio Broglio; Emanuela Arvat; Andrea Benso; Cristina Gottero; Flavia Prodam; Silvia Grottoli; Mauro Papotti; Giampiero Muccioli; Aart Jan Van der Lely; Romano Deghenghi; Ezio Ghigo
Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans.
The Journal of clinical endocrinology and metabolism 2002;87(8):3783-90.
2002: Fabio Broglio; Andrea Benso; Cristina Gottero; Flavia Prodam; Silvia Grottoli; Francesco Tassone; Mauro Maccario; Felipe F Casanueva; Carlos Dieguez; Romano Deghenghi; Ezio Ghigo; Emanuela Arvat
Effects of glucose, free fatty acids or arginine load on the GH-releasing activity of ghrelin in humans.
Clinical endocrinology 2002;57(2):265-71.
2002: Fabio Broglio; Fabio Guarracino; Andrea Benso; Cristina Gottero; Flavia Prodam; Riccarda Granata; Enrico Avogadri; Giampiero Muccioli; Romano Deghenghi; Ezio Ghigo
Effects of acute hexarelin administration on cardiac performance in patients with coronary artery disease during by-pass surgery.
European journal of pharmacology 2002;448(2-3):193-200.
2002: Gianluca Aimaretti; Claudia Baffoni; Fabio Broglio; Joop A M J L Janssen; Ginevra Corneli; Romano Deghenghi; Aart Jan Van der Lely; Ezio Ghigo; Emanuela Arvat
Endocrine responses to ghrelin in adult patients with isolated childhood-onset growth hormone deficiency.
Clinical endocrinology 2002;56(6):765-71.
2002: Lidia Di Vito; Fabio Broglio; Andrea Benso; Cristina Gottero; Flavia Prodam; Mauro Papotti; Giampiero Muccioli; Carlos Dieguez; Felipe F Casanueva; Romano Deghenghi; Ezio Ghigo; Emanuela Arvat
The GH-releasing effect of ghrelin, a natural GH secretagogue, is only blunted by the infusion of exogenous somatostatin in humans.
Clinical endocrinology 2002;56(5):643-8.
2002: Antonio Torsello; Corrado Ghe'; Elena Bresciani; Filomena Catapano; Ezio Ghigo; Romano Deghenghi; Vittorio Locatelli; Giampiero Muccioli
Short ghrelin peptides neither displace ghrelin binding in vitro nor stimulate GH release in vivo.
Endocrinology 2002;143(5):1968-71.
2002: Giampiero Muccioli; Matthias H Tschöp; Mauro Papotti; Romano Deghenghi; Mark L Heiman; Ezio Ghigo
Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity.
European journal of pharmacology 2002;440(2-3):235-54.
2002: Paola Cassoni; Giampiero Muccioli; Tiziana Marrocco; Marco Volante; Elena Allia; Ezio Ghigo; Romano Deghenghi; Mauro Papotti
Cortistatin-14 inhibits cell proliferation of human thyroid carcinoma cell lines of both follicular and parafollicular origin.
Journal of endocrinological investigation 2002;25(4):362-8.
2002: Marco Volante; Elena Allìa; Patrizia Gugliotta; Ada Funaro; Fabio Broglio; Romano Deghenghi; Giampiero Muccioli; Ezio Ghigo; Mauro Papotti
Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors.
The Journal of clinical endocrinology and metabolism 2002;87(3):1300-8.
2002: Mauro Maccario; Johannes D Veldhuis; Fabio Broglio; Lidia Di Vito; Emanuela Arvat; Romano Deghenghi; Ezio Ghigo
Impact of two or three daily subcutaneous injections of hexarelin, a synthetic growth hormone (GH) secretagogue, on 24-h GH, prolactin, adrenocorticotropin and cortisol secretion in humans.
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(3):310-8.
2002: Valeria Sibilia; Francesca Pagani; Francesca Guidobono; Vittorio Locatelli; Antonio Torsello; Romano Deghenghi; Carmela Netti
Evidence for a central inhibitory role of growth hormone secretagogues and ghrelin on gastric acid secretion in conscious rats.
Neuroendocrinology 2002;75(2):92-7.
2002: Corrado Ghè; Paola Cassoni; Filomena Catapano; Tiziana Marrocco; Romano Deghenghi; Ezio Ghigo; Giampiero Muccioli; Mauro Papotti
The antiproliferative effect of synthetic peptidyl GH secretagogues in human CALU-1 lung carcinoma cells.
Endocrinology 2002;143(2):484-91.
2002: Cristina Gottero; Andrea Benso; Flavia Prodam; Fabio Broglio; C Castiglioni; Mario Bo; Romano Deghenghi; Ezio Ghigo; Emanuela Arvat
Age-related variations of the GH response to GH secretagogues in humans.
Journal of endocrinological investigation 2002;25(10 Suppl):42-3.
2001: Romano Deghenghi; Roberta Avallone; Antonio Torsello; G Muccioli; E Ghigo; Vittorio Locatelli
Growth hormone-inhibiting activity of cortistatin in the rat.
Journal of endocrinological investigation 2001;24(11):RC31-3.
2001: Antonello E Rigamonti; G Cavallera; Sara M Bonomo; Romano Deghenghi; Vittorio Locatelli; Silvano G Cella; Eugenio E Müller
Growth hormone (GH) rebound rise following somatostatin infusion withdrawal: studies in dogs with the use of GH-releasing hormone and a GH-releasing peptide.
European journal of endocrinology / European Federation of Endocrine Societies 2001;145(5):635-44.
2001: Fabio Broglio; Emanuela Arvat; Andrea Benso; Cristina Gottero; Giampiero Muccioli; Mauro Papotti; Aart Jan Van der Lely; Romano Deghenghi; Ezio Ghigo
Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans.
The Journal of clinical endocrinology and metabolism 2001;86(10):5083-6.
2001: Mauro Papotti; Paola Cassoni; Marco Volante; Romano Deghenghi; Giampiero Muccioli; Ezio Ghigo
Ghrelin-producing endocrine tumors of the stomach and intestine.
The Journal of clinical endocrinology and metabolism 2001;86(10):5052-9.
2001: Maria Rosaria Melis; Salvatora Succu; M Sabrina Spano; Romano Deghenghi; Antonio Argiolas
EP 91073 prevents EP 80661-induced penile erection: new evidence for the existence of specific EP peptide receptors mediating penile erection.
Neuropharmacology 2001;41(2):254-62.
2001: M Roumi; E Kwong; Romano Deghenghi; Vittorio Locatelli; Sylvie Marleau; Patrick Du Souich; R Béliveau; Huy Ong
Permeability of the peptidic GH secretagogues hexarelin and EP 51389, across rat jejunum.
Peptides 2001;22(7):1129-38.
2001: Paola Cassoni; Mauro Papotti; Corrado Ghè; Filomena Catapano; Anna Sapino; Andrea Graziani; Romano Deghenghi; T Reissmann; Ezio Ghigo; Giampiero Muccioli
Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines.
The Journal of clinical endocrinology and metabolism 2001;86(4):1738-45.
2001: Giampiero Muccioli; Mauro Papotti; Vittorio Locatelli; Ezio Ghigo; Romano Deghenghi
Binding of 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland.
Journal of endocrinological investigation 2001;24(3):RC7-9.
2001: Emanuela Arvat; Mauro Maccario; Lidia Di Vito; Fabio Broglio; Andrea Benso; Cristina Gottero; Mauro Papotti; Giampiero Muccioli; Carlos Dieguez; Felipe F Casanueva; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone.
The Journal of clinical endocrinology and metabolism 2001;86(3):1169-74.
2001: Ezio Ghigo; Emanuela Arvat; Roberta Giordano; Fabio Broglio; Laura Gianotti; Mauro Maccario; Gianni Bisi; Andrea Graziani; Mauro Papotti; Giampiero Muccioli; Romano Deghenghi; Franco Camanni
Biologic activities of growth hormone secretagogues in humans.
Endocrine 2001;14(1):87-93.
2001: Emanuela Arvat; Laura Gianotti; Roberta Giordano; Fabio Broglio; Mauro Maccario; Fabio Lanfranco; Giampiero Muccioli; Mauro Papotti; Andrea Graziani; Ezio Ghigo; Romano Deghenghi
Growth hormone-releasing hormone and growth hormone secretagogue-receptor ligands: focus on reproductive system.
Endocrine 2001;14(1):35-43.
2001: Nicoletta Filigheddu; Alberto Fubini; Gianluca Baldanzi; Santina Cutrupi; Corrado Ghè; Filomena Catapano; Fabio Broglio; Amalia Bosia; Mauro Papotti; Giampiero Muccioli; Ezio Ghigo; Romano Deghenghi; Andrea Graziani
Hexarelin protects H9c2 cardiomyocytes from doxorubicin-induced cell death.
Endocrine 2001;14(1):113-9.
2001: Antonello E Rigamonti; Silvano G Cella; G M Cavallera; Romano Deghenghi; Vittorio Locatelli; Nikolaos Pitsikas; Eugenio E Müller
Contrasting effects of nitric oxide on food intake and GH secretion stimulated by a GH-releasing peptide.
European journal of endocrinology / European Federation of Endocrine Societies 2001;144(2):155-62.
2001: Maria Rosaria Melis; Salvatora Succu; M Sabrina Spano; Antonio Torsello; Vittorio Locatelli; Eugenio E Muller; Romano Deghenghi; Antonio Argiolas
Penile erection induced by EP 80661 and other hexarelin peptide analogues: involvement of paraventricular nitric oxide.
European journal of pharmacology 2001;411(3):305-10.
2000: Antonio Torsello; Vittorio Locatelli; Maria Rosaria Melis; Salvatora Succu; M Sabrina Spano; Romano Deghenghi; Eugenio E Müller; Antonio Argiolas
Differential orexigenic effects of hexarelin and its analogs in the rat hypothalamus: indication for multiple growth hormone secretagogue receptor subtypes.
Neuroendocrinology 2000;72(6):327-32.
2000: Maria Rosaria Melis; M Sabrina Spano; Salvatora Succu; Vittorio Locatelli; Antonio Torsello; Eugenio E Muller; Romano Deghenghi; Antonio Argiolas
EP 60761- and EP 50885-induced penile erection: structure-activity studies and comparison with apomorphine, oxytocin and N-methyl-D-aspartic acid.
International journal of impotence research 2000;12(5):255-62.
2000: Mauro Papotti; Corrado Ghè; Paola Cassoni; Filomena Catapano; Romano Deghenghi; Ezio Ghigo; Giampiero Muccioli
Growth hormone secretagogue binding sites in peripheral human tissues.
The Journal of clinical endocrinology and metabolism 2000;85(10):3803-7.
2000: Maria Rosaria Melis; Salvatora Succu; M Sabrina Spano; Vittorio Locatelli; Antonio Torsello; Eugenio E Muller; Romano Deghenghi; Antonio Argiolas
EP 60761 and EP 50885, two hexarelin analogues, induce penile erection in rats.
European journal of pharmacology 2000;404(1-2):137-43.
2000: Fabio Broglio; Andrea Benso; Cristina Gottero; Giampiero Muccioli; Romano Deghenghi; Ezio Ghigo; Emanuela Arvat
Endocrine activities of alexamorelin (Ala-His-d-2-methyl-Trp-Ala-Trp-d-Phe-Lys-NH2), a synthetic GH secretagogue, in humans.
European journal of endocrinology / European Federation of Endocrine Societies 2000;143(3):419-25.
2000: Emanuela Arvat; Lidia Di Vito; Fabio Broglio; Mauro Papotti; Giampiero Muccioli; Carlos Dieguez; Felipe F Casanueva; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans.
Journal of endocrinological investigation 2000;23(8):493-5.
2000: Romano Deghenghi
Reflections on growth hormone.
Journal of endocrinological investigation 2000;23(7):480-1.
2000: Silvia Grottoli; Emanuela Arvat; Carlotta Gauna; B Maccagno; Josefina Ramunni; Roberta Giordano; Mauro Maccario; Romano Deghenghi; Ezio Ghigo
Alprazolam, a benzodiazepine, blunts but does not abolish the ACTH and cortisol response to hexarelin, a GHRP, in obese patients.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24 Suppl 2():S136-7.
2000: Paola Cassoni; Mauro Papotti; Filomena Catapano; Corrado Ghè; Romano Deghenghi; Ezio Ghigo; Giampiero Muccioli
Specific binding sites for synthetic growth hormone secretagogues in non-tumoral and neoplastic human thyroid tissue.
The Journal of endocrinology 2000;165(1):139-46.
2000: Giampiero Muccioli; Fabio Broglio; MR Valetto; Corrado Ghè; Filomena Catapano; Andrea Graziani; Mauro Papotti; Gianni Bisi; Romano Deghenghi; Ezio Ghigo
Growth hormone-releasing peptides and the cardiovascular system.
Annales d'endocrinologie 2000;61(1):27-31.
2000: M Roumi; Sylvie Marleau; Patrick Du Souich; T Maggi; Romano Deghenghi; Huy Ong
Kinetics and disposition of hexarelin, a peptidic growth hormone secretagogue, in rats.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(1):44-50.
1999: Silvia Grottoli; Emanuela Arvat; Carlotta Gauna; B Maccagno; Josefina Ramunni; Roberta Giordano; Mauro Maccario; Romano Deghenghi; Ezio Ghigo
Effects of alprazolam, a benzodiazepine, on the ACTH-, GH- and PRL-releasing activity of hexarelin, a synthetic peptidyl GH secretagogue (GHS), in patients with simple obesity and in patients with Cushing's disease.
Pituitary 1999;2(3):197-204.
1999: Gianni Bisi; Valerio Podio; MR Valetto; Fabio Broglio; G Bertuccio; Gianluca Aimaretti; Ettore Pelosi; G DEl Rio; Giampiero Muccioli; Huy Ong; MF Boghen; Romano Deghenghi; Ezio Ghigo
Cardiac effects of hexarelin in hypopituitary adults.
European journal of pharmacology 1999;381(1):31-8.
1999: Emanuela Arvat; Josefina Ramunni; B Maccagno; Roberta Giordano; Fabio Broglio; Romano Deghenghi; Marco Boscaro; Ezio Ghigo
Corticotropin-releasing effect of hexarelin, a peptidyl GH secretagogue, in normal subjects pretreated with metyrapone or RU-486, a glucocorticoid receptor antagonist, and in patients with Addison's disease.
Neuroendocrinology 1999;70(3):200-6.
1999: Vittorio Locatelli; Giuseppe Rossoni; F Schweiger; Antonio Torsello; Vito De Gennaro Colonna; MM Bernareggi; Romano Deghenghi; Eugenio E Müller; Ferruccio Berti
Growth hormone-independent cardioprotective effects of hexarelin in the rat.
Endocrinology 1999;140(9):4024-31.
1999: Fabio Broglio; Alberto Fubini; Mara Morello; Emanuela Arvat; Gianluca Aimaretti; Laura Gianotti; MF Boghen; Romano Deghenghi; Lucia Mangiardi; Ezio Ghigo
Activity of GH/IGF-I axis in patients with dilated cardiomyopathy.
Clinical endocrinology 1999;50(4):417-30.
1999: Gianni Bisi; Valerio Podio; MR Valetto; Fabio Broglio; G Bertuccio; G DEl Rio; Emanuela Arvat; MF Boghen; Romano Deghenghi; Giampiero Muccioli; Huy Ong; Ezio Ghigo
Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans.
Journal of endocrinological investigation 1999;22(4):266-72.
1999: Emanuela Arvat; Lidia Di Vito; Fabio Lanfranco; Fabio Broglio; Roberta Giordano; Andrea Benso; Giampiero Muccioli; Romano Deghenghi; Ezio Ghigo
Tyr-Ala-Hexarelin, a synthetic octapeptide, possesses the same endocrine activities of Hexarelin and GHRP-2 in humans.
Journal of endocrinological investigation 1999;22(2):91-7.
1999: Ezio Ghigo; Emanuela Arvat; Fabio Broglio; Roberta Giordano; Laura Gianotti; Giampiero Muccioli; Mauro Papotti; Andrea Graziani; Gianni Bisi; Romano Deghenghi; Franco Camanni
Endocrine and non-endocrine activities of growth hormone secretagogues in humans.
Hormone research 1999;51 Suppl 3():9-15.
1999: Emanuela Arvat; Josefina Ramunni; Roberta Giordano; B Maccagno; Fabio Broglio; Andrea Benso; Romano Deghenghi; Ezio Ghigo
Effects of the combined administration of hexarelin, a synthetic peptidyl GH secretagogue, and hCRH on ACTH, cortisol and GH secretion in patients with Cushing's disease.
Journal of endocrinological investigation 1999;22(1):23-8.
1998: Romano Deghenghi
Synthetic peptides and their non-peptidyl mimetics in endocrinology: from synthesis to clinical perspectives.
Journal of endocrinological investigation 1998;21(11):787-93.
1998: Antonio Torsello; Marina Luoni; F Schweiger; R Grilli; M Guidi; Elena Bresciani; Romano Deghenghi; Eugenio E Müller; Vittorio Locatelli
Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release.
European journal of pharmacology 1998;360(2-3):123-9.
1998: Emanuela Arvat; B Maccagno; Josefina Ramunni; Fabio Broglio; Fabio Lanfranco; Roberta Giordano; Andrea Benso; Romano Deghenghi; Ezio Ghigo
Influence of galanin and serotonin on the endocrine response to Hexarelin, a synthetic peptidyl GH-secretagogue, in normal women.
Journal of endocrinological investigation 1998;21(10):673-9.
1998: Jaele Bellone; E Bartolotta; C Sgattoni; Gianluca Aimaretti; Emanuela Arvat; Simonetta Bellone; Romano Deghenghi; Ezio Ghigo
Hexarelin, a synthetic GH-releasing peptide, is a powerful stimulus of GH secretion in pubertal children and in adults but not in prepubertal children and in elderly subjects.
Journal of endocrinological investigation 1998;21(8):494-500.
1998: Emanuela Arvat; B Maccagno; Josefina Ramunni; Lidia Di Vito; Laura Gianotti; Fabio Broglio; Andrea Benso; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Effects of dexamethasone and alprazolam, a benzodiazepine, on the stimulatory effect of hexarelin, a synthetic GHRP, on ACTH, cortisol and GH secretion in humans.
Neuroendocrinology 1998;67(5):310-6.
1998: Emanuela Arvat; Gian Paolo Ceda; Lidia Di Vito; Josefina Ramunni; Laura Gianotti; Fabio Broglio; Romano Deghenghi; Ezio Ghigo
Age-related variations in the neuroendocrine control, more than impaired receptor sensitivity, cause the reduction in the GH-releasing activity of GHRPs in human aging.
Pituitary 1998;1(1):51-8.
1998: Giampiero Muccioli; Corrado Ghè; M C Ghigo; Mauro Papotti; Emanuela Arvat; MF Boghen; MH Nilsson; Romano Deghenghi; Huy Ong; Ezio Ghigo
Specific receptors for synthetic GH secretagogues in the human brain and pituitary gland.
The Journal of endocrinology 1998;157(1):99-106.
1998: Huy Ong; Normand McNicoll; E Escher; R Collu; Romano Deghenghi; Vittorio Locatelli; Ezio Ghigo; Giampiero Muccioli; MF Boghen; MH Nilsson
Identification of a pituitary growth hormone-releasing peptide (GHRP) receptor subtype by photoaffinity labeling.
Endocrinology 1998;139(1):432-5.
1997: Emanuela Arvat; Josefina Ramunni; Jaele Bellone; Lidia Di Vito; Claudia Baffoni; Fabio Broglio; Romano Deghenghi; E Bartolotta; Ezio Ghigo
The GH, prolactin, ACTH and cortisol responses to Hexarelin, a synthetic hexapeptide, undergo different age-related variations.
European journal of endocrinology / European Federation of Endocrine Societies 1997;137(6):635-42.
1997: Emanuela Arvat; B Maccagno; Josefina Ramunni; Lidia Di Vito; Fabio Broglio; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Hexarelin, a synthetic growth-hormone releasing peptide, shows no interaction with corticotropin-releasing hormone and vasopressin on adrenocorticotropin and cortisol secretion in humans.
Neuroendocrinology 1997;66(6):432-8.
1997: Romano Deghenghi
The development of 'impervious peptides' as growth hormone secretagogues.
Acta paediatrica (Oslo, Norway : 1992). Supplement 1997;423():85-7.
1997: Emanuela Arvat; Lidia Di Vito; Josefina Ramunni; Laura Gianotti; Roberta Giordano; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Low hexarelin dose and pyridostigmine have additive effect and potentiate to the same extent the GHRH-induced GH response in man.
Clinical endocrinology 1997;47(4):495-500.
1997: E Bartolotta; Jaele Bellone; Gianluca Aimaretti; Emanuela Arvat; Lodovico Benso; Romano Deghenghi; Franco Camanni; Ezio Ghigo
The GH-releasing effect of Hexarelin, a synthetic hexapeptide, in newborns is lower than in young adults.
Journal of pediatric endocrinology & metabolism : JPEM 1997;10(5):491-7.
1997: Ezio Ghigo; Emanuela Arvat; Josefina Ramunni; Annamaria Colao; Laura Gianotti; Romano Deghenghi; Gaetano Lombardi; Franco Camanni
Adrenocorticotropin- and cortisol-releasing effect of hexarelin, a synthetic growth hormone-releasing peptide, in normal subjects and patients with Cushing's syndrome.
The Journal of clinical endocrinology and metabolism 1997;82(8):2439-44.
1997: Emanuela Arvat; Laura Gianotti; Fabio Broglio; B Maccagno; Angela Bertagna; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Oestrogen replacement does not restore the reduced GH-releasing activity of Hexarelin, a synthetic hexapeptide, in post-menopausal women.
European journal of endocrinology / European Federation of Endocrine Societies 1997;136(5):483-7.
1997: Emanuela Arvat; B Maccagno; Josefina Ramunni; Laura Gianotti; Lidia Di Vito; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Effects of histaminergic antagonists on the GH-releasing activity of GHRH or hexarelin, a synthetic hexapeptide, in man.
Journal of endocrinological investigation 1997;20(3):122-7.
1997: Antonio Torsello; Marina Luoni; R Grilli; M Guidi; W B Wehrenberg; Romano Deghenghi; Eugenio E Müller; Vittorio Locatelli
Hexarelin stimulation of growth hormone release and mRNA levels in an infant and adult rat model of impaired GHRH function.
Neuroendocrinology 1997;65(2):91-7.
1997: Eveline Hudon; J J Rondeau; Vincent Lenaerts; P Würthrich; François Boutignon; Romano Deghenghi; Sylvie Marleau; N Yamaguchi; A Adam; Huy Ong
Radioimmunoassay of meterelin and pharmacokinetics after single injection and implant administration in dogs.
Journal of pharmaceutical sciences 1997;86(2):172-8.
1997: Emanuela Arvat; Lidia Di Vito; B Maccagno; Fabio Broglio; MF Boghen; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Effects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man. Comparison with the effects of GHRH, TRH and hCRH.
Peptides 1997;18(6):885-91.
1997: Emanuela Arvat; Lidia Di Vito; Laura Gianotti; Josefina Ramunni; MF Boghen; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Mechanisms underlying the negative growth hormone (GH) autofeedback on the GH-releasing effect of hexarelin in man.
Metabolism: clinical and experimental 1997;46(1):83-8.
1996: Silvia Grottoli; Mauro Maccario; Massimo Procopio; SE Oleandri; Emanuela Arvat; Laura Gianotti; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Somatotrope responsiveness to Hexarelin, a synthetic hexapeptide, is refractory to the inhibitory effect of glucose in obesity.
European journal of endocrinology / European Federation of Endocrine Societies 1996;135(6):678-82.
1996: Antonio Torsello; R Grilli; Marina Luoni; M Guidi; M C Ghigo; W B Wehrenberg; Romano Deghenghi; Eugenio E Müller; Vittorio Locatelli
Mechanism of action of Hexarelin. I. Growth hormone-releasing activity in the rat.
European journal of endocrinology / European Federation of Endocrine Societies 1996;135(4):481-8.
1996: Ezio Ghigo; Emanuela Arvat; Laura Gianotti; Silvia Grottoli; G Rizzi; Gian Paolo Ceda; MF Boghen; Romano Deghenghi; Franco Camanni
Short-term administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone responsiveness in human aging.
European journal of endocrinology / European Federation of Endocrine Societies 1996;135(4):407-12.
1996: S Sorensen; J J Rondeau; Vincent Lenaerts; F Boutignon; P Wüthrich; Romano Deghenghi; Albert Adam; Huy Ong
Radioimmunoassay of Antarelix, a luteinizing hormone releasing-hormone antagonist, in plasma and its application for pharmacokinetic study in dogs.
Journal of immunoassay 1996;17(3):205-26.
1996: B Klinger; Aviva Silbergeld; Romano Deghenghi; J Frenkel; Zvi Laron
Desensitization from long-term intranasal treatment with hexarelin does not interfere with the biological effects of this growth hormone-releasing peptide in short children.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(6):716-9.
1996: Andrea Giustina; P Desenzani; P Perini; Romano Deghenghi; Giovanna Bugari; William B Wehrenberg; G Giustina
Hypothalamic control of growth hormone (GH) secretion in type I diabetic men: effect of the combined administration of GH-releasing hormone and hexarelin, a novel GHRP-6 analog.
Endocrine research 1996;22(2):159-74.
1996: Emanuela Arvat; Laura Gianotti; Josefina Ramunni; L DiVito; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Influence of beta-adrenergic agonists and antagonists on the GH-releasing effect of Hexarelin in man.
Journal of endocrinological investigation 1996;19(1):25-9.
1996: Enrica Ciccarelli; Silvia Grottoli; Paola Razzore; Laura Gianotti; Emanuela Arvat; Romano Deghenghi; G Camanni; Ezio Ghigo
Hexarelin, a synthetic growth hormone releasing peptide, stimulates prolactin secretion in acromegalic but not in hyperprolactinaemic patients.
Clinical endocrinology 1996;44(1):67-71.
1995: Zvi Laron; J Frenkel; Romano Deghenghi; S Anin; B Klinger; Aviva Silbergeld
Intranasal administration of the GHRP hexarelin accelerates growth in short children.
Clinical endocrinology 1995;43(5):631-5.
1995: Romano Deghenghi; F Boutignon; Marina Luoni; R Grilli; M Guidi; V Locatelli
Small peptides as potent releasers of growth hormone.
Journal of pediatric endocrinology & metabolism : JPEM 1995;8(4):311-3.
1995: Sandro Loche; P Cambiaso; B Merola; A Colao; Antonella Faedda; B P Imbimbo; Romano Deghenghi; G Lombardi; Marco Cappa
The effect of hexarelin on growth hormone (GH) secretion in patients with GH deficiency.
The Journal of clinical endocrinology and metabolism 1995;80(9):2692-6.
1995: Andrea Giustina; E Bresciani; Giovanna Bugari; A R Bussi; Romano Deghenghi; B Imbimbo; G Giustina
Hexarelin, a novel GHRP-6 analog, counteracts the inhibitory effect of hydrocortisone on growth hormone secretion in acromegaly.
Endocrine research 1995;21(3):569-82.
1995: Andrea Giustina; A R Bussi; Romano Deghenghi; B Imbimbo; M Licini; Claudio Poiesi; William B Wehrenberg
Comparison of the effects of growth hormone-releasing hormone and hexarelin, a novel growth hormone-releasing peptide-6 analog, on growth hormone secretion in humans with or without glucocorticoid excess.
The Journal of endocrinology 1995;146(2):227-32.
1995: Jaele Bellone; Gianluca Aimaretti; E Bartolotta; Lodovico Benso; BP Imbimbo; V Lenhaerts; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, before and during puberty.
The Journal of clinical endocrinology and metabolism 1995;80(4):1090-4.
1995: M Roumi; Vincent Lenaerts; F Boutignon; P Wuthrich; Romano Deghenghi; M Bellemare; Albert Adam; Huy Ong
Radioimmunoassay for hexarelin, a peptidic growth hormone secretagogue, and its pharmacokinetic studies.
Peptides 1995;16(7):1301-6.
1995: Mauro Maccario; Emanuela Arvat; Massimo Procopio; Laura Gianotti; Silvia Grottoli; BP Imbimbo; Vincent Lenaerts; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Metabolic modulation of the growth hormone-releasing activity of hexarelin in man.
Metabolism: clinical and experimental 1995;44(1):134-8.
1995: Emanuela Arvat; Laura Gianotti; Lidia Di Vito; BP Imbimbo; Vincent Lenaerts; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Modulation of growth hormone-releasing activity of hexarelin in man.
Neuroendocrinology 1995;61(1):51-6.
1995: Eugenio E Müller; Silvano G Cella; Marco Parenti; Romano Deghenghi; Vittorio Locatelli; Vito De Gennaro Colonna; Antonio Torsello; Daniela Cocchi
Somatotropic dysregulation in old mammals.
Hormone research 1995;43(1-3):39-45.
1995: Silvano G Cella; Vittorio Locatelli; M Poratelli; Vito De Gennaro Colonna; BP Imbimbo; Romano Deghenghi; Eugenio E Müller
Hexarelin, a potent GHRP analogue: interactions with GHRH and clonidine in young and aged dogs.
Peptides 1995;16(1):81-6.
1995: J Frenkel; Aviva Silbergeld; Romano Deghenghi; Zvi Laron
Short term effect of intranasal administration of hexarelin--a synthetic growth hormone-releasing peptide. Preliminary communication.
Journal of pediatric endocrinology & metabolism : JPEM 1995;8(1):43-5.
1994: Emanuela Arvat; Laura Gianotti; Silvia Grottoli; BP Imbimbo; Vincent Lenaerts; Romano Deghenghi; Franco Camanni; Ezio Ghigo
Arginine and growth hormone-releasing hormone restore the blunted growth hormone-releasing activity of hexarelin in elderly subjects.
The Journal of clinical endocrinology and metabolism 1994;79(5):1440-3.
1994: Zvi Laron; J Frenkel; Irit Gil-Ad; B Klinger; E Lubin; P Wuthrich; F Boutignon; V Lengerts; Romano Deghenghi
Growth hormone releasing activity by intranasal administration of a synthetic hexapeptide (hexarelin).
Clinical endocrinology 1994;41(4):539-41.
1994: Viviane Guillaume; E Magnan; mauro cataldi; Anne Dutour; Nicole Sauze; M Renard; H Razafindraibe; B Conte-Devolx; Romano Deghenghi; Vincent Lenaerts
Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep.
Endocrinology 1994;135(3):1073-6.
1994: Ezio Ghigo; Emanuela Arvat; Laura Gianotti; BP Imbimbo; Vincent Lenaerts; Romano Deghenghi; Franco Camanni
Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man.
The Journal of clinical endocrinology and metabolism 1994;78(3):693-8.
1994: BP Imbimbo; Timothy G K Mant; M Edwards; D Amin; N Dalton; F Boutignon; Vincent Lenaerts; P Wüthrich; Romano Deghenghi
Growth hormone-releasing activity of hexarelin in humans. A dose-response study.
European journal of clinical pharmacology 1994;46(5):421-5.
1994: Romano Deghenghi; M M Cananzi; Antonio Torsello; C Battisti; Eugenio E Muller; Vittorio Locatelli
GH-releasing activity of Hexarelin, a new growth hormone releasing peptide, in infant and adult rats.
Life sciences 1994;54(18):1321-8.
1993: Romano Deghenghi; F Boutignon; P Wüthrich; Vincent Lenaerts
Antarelix (EP 24332) a novel water soluble LHRH antagonist.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1993;47(2-3):107-10.