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Sigmund Degitz

Research Profile

Living Beings

Chemicals & Drugs

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Physiology

Gene Expression Regulation, Developmental

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Publications

TOP 3
Joseph E Tietge; Joseph J Korte; Patricia A Kosian; Annelie J Lindberg-Livingston; Pamela E Blackshear; Emily M Burgess; Brian C Butterworth; Sigmund J Degitz; Jonathan T Haselman; Michael W Hornung
Inhibition of the thyroid hormone pathway in Xenopus laevis by 2-mercaptobenzothiazole.
Allen W Olmstead; Kacie K Woodis; Blake A Bennett; Pamela E Blackshear; Chad Blanksma; Emily Burgess; Jonathan Haselman; Gary W Holcombe; Rodney Johnson; Joseph J Korte; Patricia A Kosian; Annelie Lindberg-Livingston; Sigmund J Degitz
Trenbolone causes mortality and altered sexual differentiation in Xenopus tropicalis during larval development.
Robin M Sternberg; Kara R Thoemke; Joseph E Tietge; Joseph J Korte; Lisa Korte; Scott M Moen; Jessica M Olson; Sigmund J Degitz
Control of pituitary thyroid-stimulating hormone synthesis and secretion by thyroid hormones during Xenopus metamorphosis.

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All Publications

2013: Joseph E Tietge; Joseph J Korte; Patricia A Kosian; Annelie J Lindberg-Livingston; Pamela E Blackshear; Emily M Burgess; Brian C Butterworth; Sigmund J Degitz; Jonathan T Haselman; Michael W Hornung
Inhibition of the thyroid hormone pathway in Xenopus laevis by 2-mercaptobenzothiazole.
Aquatic toxicology (Amsterdam, Netherlands) 2013;126():128-36.
2012: Allen W Olmstead; Kacie K Woodis; Blake A Bennett; Pamela E Blackshear; Chad Blanksma; Emily Burgess; Jonathan Haselman; Gary W Holcombe; Rodney Johnson; Joseph J Korte; Patricia A Kosian; Annelie Lindberg-Livingston; Sigmund J Degitz
Trenbolone causes mortality and altered sexual differentiation in Xenopus tropicalis during larval development.
Environmental toxicology and chemistry / SETAC 2012;31(10):2391-8.
2011: Robin M Sternberg; Kara R Thoemke; Joseph E Tietge; Joseph J Korte; Lisa Korte; Scott M Moen; Jessica M Olson; Sigmund J Degitz
Control of pituitary thyroid-stimulating hormone synthesis and secretion by thyroid hormones during Xenopus metamorphosis.
General and comparative endocrinology 2011;173(3):428-37.
2011: Karen L Porter; Allen W Olmstead; David M Kumsher; William E Dennis; Robert L Sprando; Gary W Holcombe; Joseph J Korte; Annelie Lindberg-Livingston; Sigmund J Degitz
Effects of 4-tert-octylphenol on Xenopus tropicalis in a long term exposure.
Aquatic toxicology (Amsterdam, Netherlands) 2011;103(3-4):159-69.
2011: Joseph J Korte; Robin M Sternberg; Jose A Serrano; Kara R Thoemke; Scott M Moen; Kathryn E Lillegard; Michael W Hornung; Joseph E Tietge; Sigmund J Degitz
Thyroid-stimulating hormone (TSH): measurement of intracellular, secreted, and circulating hormone in Xenopus laevis and Xenopus tropicalis.
General and comparative endocrinology 2011;171(3):319-25.
2011: Allen W Olmstead; Daniel L Villeneuve; Gerald T Ankley; Jenna E Cavallin; Annelie Lindberg-Livingston; Leah C Wehmas; Sigmund J Degitz
A method for the determination of genetic sex in the fathead minnow, Pimephales promelas, to support testing of endocrine-active chemicals.
Environmental science & technology 2011;45(7):3090-5.
2010: Michael W Hornung; Sigmund J Degitz; Lisa M Korte; Jessica M Olson; Patricia A Kosian; Ann Linnum; Joseph E Tietge
Inhibition of thyroid hormone release from cultured amphibian thyroid glands by methimazole, 6-propylthiouracil, and perchlorate.
Toxicological sciences : an official journal of the Society of Toxicology 2010;118(1):42-51.
2010: Kristin A Connors; Joseph J Korte; Grant W Anderson; Sigmund J Degitz
Characterization of thyroid hormone transporter expression during tissue-specific metamorphic events in Xenopus tropicalis.
General and comparative endocrinology 2010;168(1):149-59.
2010: Jose Serrano; Lee nn Higgins; bruce witthuhn; Lorraine B Anderson; Todd Markowski; Gary W Holcombe; Patricia A Kosian; Joseph J Korte; Joseph E Tietge; Sigmund J Degitz
In vivo assessment and potential diagnosis of xenobiotics that perturb the thyroid pathway: Proteomic analysis of Xenopus laevis brain tissue following exposure to model T4 inhibitors.
Comparative biochemistry and physiology. Part D, Genomics & proteomics 2010;5(2):138-50.
2010: Allen W Olmstead; Annelie Lindberg-Livingston; Sigmund J Degitz
Genotyping sex in the amphibian, Xenopus (Silurana) tropicalis, for endocrine disruptor bioassays.
Aquatic toxicology (Amsterdam, Netherlands) 2010;98(1):60-6.
2010: Joseph E Tietge; Brian C Butterworth; Jonathan T Haselman; Gary W Holcombe; Michael W Hornung; Joseph J Korte; Patricia A Kosian; Marilyn Wolfe; Sigmund J Degitz
Early temporal effects of three thyroid hormone synthesis inhibitors in Xenopus laevis.
Aquatic toxicology (Amsterdam, Netherlands) 2010;98(1):44-50.
2009: Allen W Olmstead; Patricia A Kosian; Joseph J Korte; Gary W Holcombe; Kacie K Woodis; Sigmund J Degitz
Sex reversal of the amphibian, Xenopus tropicalis, following larval exposure to an aromatase inhibitor.
Aquatic toxicology (Amsterdam, Netherlands) 2009;91(2):143-50.
2009: Allen W Olmstead; Joseph J Korte; Kacie K Woodis; Blake A Bennett; Shannon Ostazeski; Sigmund J Degitz
Reproductive maturation of the tropical clawed frog: Xenopus tropicalis.
General and comparative endocrinology 2009;160(2):117-23.
2007: Caren C Helbing; Carmen M Bailey; Lan Ji; Mark P Gunderson; Fang Zhang; Nik Veldhoen; Rachel C Skirrow; Ruixia Mu; Mary Lesperance; Gary W Holcombe; Patricia A Kosian; Joseph E Tietge; Joseph J Korte; Sigmund J Degitz
Identification of gene expression indicators for thyroid axis disruption in a Xenopus laevis metamorphosis screening assay. Part 1. Effects on the brain.
Aquatic toxicology (Amsterdam, Netherlands) 2007;82(4):227-41.
2007: Caren C Helbing; Lan Ji; Carmen M Bailey; Nik Veldhoen; Fang Zhang; Gary W Holcombe; Patricia A Kosian; Joseph E Tietge; Joseph J Korte; Sigmund J Degitz
Identification of gene expression indicators for thyroid axis disruption in a Xenopus laevis metamorphosis screening assay. Part 2. Effects on the tail and hindlimb.
Aquatic toxicology (Amsterdam, Netherlands) 2007;82(4):215-26.
2007: Daniel L Villeneuve; Ann L Miracle; Kathleen M Jensen; Sigmund J Degitz; Michael D Kahl; Joseph J Korte; Katie J Greene; Lindsey S Blake; Ann Linnum; Gerald T Ankley
Development of quantitative real-time PCR assays for fathead minnow (Pimephales promelas) gonadotropin beta subunit mRNAs to support endocrine disruptor research.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2007;145(2):171-83.
2007: Douglas J Fort; Sigmund J Degitz; Joseph Tietge; Leslie W Touart
The hypothalamic-pituitary-thyroid (HPT) axis in frogs and its role in frog development and reproduction.
Critical reviews in toxicology 2007;37(1-2):117-61.
2006: Gerald T Ankley; George P Daston; Sigmund J Degitz; Nancy D Denslow; Robert A Hoke; Sean W Kennedy; Ann L Miracle; Edward J Perkins; Jason Snape; Donald E Tillitt; Charles R Tyler; Donald Versteeg
Toxicogenomics in regulatory ecotoxicology.
Environmental science & technology 2006;40(13):4055-65.
2006: Fang Zhang; Sigmund J Degitz; Gary W Holcombe; Patricia A Kosian; Joseph E Tietge; Nik Veldhoen; Caren C Helbing
Evaluation of gene expression endpoints in the context of a Xenopus laevis metamorphosis-based bioassay to detect thyroid hormone disruptors.
Aquatic toxicology (Amsterdam, Netherlands) 2006;76(1):24-36.
2005: Sigmund J Degitz; Gary W Holcombe; Kevin M Flynn; Patricia A Kosian; Joseph J Korte; Joseph E Tietge
Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis. Organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine.
Toxicological sciences : an official journal of the Society of Toxicology 2005;87(2):353-64.
2005: Joseph E Tietge; Gary W Holcombe; Kevin M Flynn; Patricia A Kosian; Joseph J Korte; Leroy E Anderson; Douglas Wolf; Sigmund J Degitz
Metamorphic inhibition of Xenopus laevis by sodium perchlorate: effects on development and thyroid histology.
Environmental toxicology and chemistry / SETAC 2005;24(4):926-33.
2004: Gerald T Ankley; Sigmund J Degitz; Stephen A Diamond; Joseph E Tietge
Assessment of environmental stressors potentially responsible for malformations in North American anuran amphibians.
Ecotoxicology and environmental safety 2004;58(1):7-16.
2004: Sigmund J Degitz; John M Rogers; Robert M Zucker; E Sidney Hunter
Developmental toxicity of methanol: Pathogenesis in CD-1 and C57BL/6J mice exposed in whole embryo culture.
Birth defects research. Part A, Clinical and molecular teratology 2004;70(4):179-84.
2004: Sigmund J Degitz; Robert M Zucker; Clinton Y Kawanishi; Gwen S Massenburg; John M Rogers
Pathogenesis of methanol-induced craniofacial defects in C57BL/6J mice.
Birth defects research. Part A, Clinical and molecular teratology 2004;70(4):172-8.
2004: John M Rogers; Kimberly C Brannen; Brenda D Barbee; Robert M Zucker; Sigmund J Degitz
Methanol exposure during gastrulation causes holoprosencephaly, facial dysgenesis, and cervical vertebral malformations in C57BL/6J mice.
Birth defects research. Part B, Developmental and reproductive toxicology 2004;71(2):80-8.
2003: Sigmund J Degitz; Gary W Holcombe; Patricia A Kosian; Joseph E Tietge; Elizabeth J Durhan; Gerald T Ankley
Comparing the effects of stage and duration of retinoic Acid exposure on amphibian limb development: chronic exposure results in mortality, not limb malformations.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(1):139-46.
2003: Patricia A Kosian; Elizabeth A Makynen; Gerald T Ankley; Sigmund J Degitz
Uptake and metabolism of all-trans retinoic acid by three native north American ranids.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(1):147-56.
2003: Sigmund J Degitz; Elizabeth J Durhan; Joseph E Tietge; Patricia A Kosian; Gary W Holcombe; Gerald T Ankley
Developmental toxicity of methoprene and several degradation products in Xenopus laevis.
Aquatic toxicology (Amsterdam, Netherlands) 2003;64(1):97-105.
2002: L Earl Gray; Joseph Ostby; Vickie Wilson; Christy Lambright; Kathy Bobseine; Phillip C Hartig; Andrew Hotchkiss; C Wolf; Johnathan Furr; M Price; Louise G Parks; Ralph L Cooper; Tammy E Stoker; Susan C Laws; Sigmund J Degitz; Kathleen M Jensen; Michael D Kahl; Joseph J Korte; Elizabeth A Makynen; Joseph E Tietge; Gerald T Ankley
Xenoendocrine disrupters-tiered screening and testing: filling key data gaps.
Toxicology 2002;181-182():371-82.
2002: R Simon; J E Tietge; B Michalke; Sigmund J Degitz; K W Schramm
Iodine species and the endocrine system: thyroid hormone levels in adult Danio rerio and developing Xenopus laevis.
Analytical and bioanalytical chemistry 2002;372(3):481-5.
2001: Joseph E Tietge; Stephen A Diamond; Gerald T Ankley; David L Defoe; Gary W Holcombe; Kathleen M Jensen; Sigmund J Degitz; G E Elonen; E Hammer
Ambient solar UV radiation causes mortality in larvae of three species of Rana under controlled exposure conditions.
Photochemistry and photobiology 2001;74(2):261-8.
2000: Sigmund J Degitz; Patricia A Kosian; Elizabeth A Makynen; Kathleen M Jensen; Gerald T Ankley
Stage- and species-specific developmental toxicity of all-trans retinoic acid in four native North American ranids and Xenopus laevis.
Toxicological sciences : an official journal of the Society of Toxicology 2000;57(2):264-74.