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William DeGrado

Research Profile

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Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

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Thermodynamics

Physiology

Protein Folding

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Publications

TOP 3
Xiaozhen Hu; Jinlei Zhao; William F DeGrado; Andrew N Binns
Agrobacterium tumefaciens recognizes its host environment using ChvE to bind diverse plant sugars as virulence signals.
Jessica L Thomaston; Mary Alice Upshur; Jun Wang; Emily C Brown; William F DeGrado; Phuong A Nguyen; Kathleen P Howard
Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling.
Melissa S Love; Melanie G Millholland; Satish Mishra; Wenxi Pan; Mortimer Poncz; Richard W Scott; Photini Sinnis; Dewight R Williams; Lawrence W Bergman; Michael J Costanzo; Thomas M Daly; William F DeGrado; Katie B Freeman; Hyunil Jo; Robert W Kavash; M Anna Kowalska; Swapnil Kulkarni; Doron C Greenbaum
Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials.

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All Publications

2013: Xiaozhen Hu; Jinlei Zhao; William F DeGrado; Andrew N Binns
Agrobacterium tumefaciens recognizes its host environment using ChvE to bind diverse plant sugars as virulence signals.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(2):678-83.
2013: Jessica L Thomaston; Mary Alice Upshur; Jun Wang; Emily C Brown; William F DeGrado; Phuong A Nguyen; Kathleen P Howard
Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling.
Protein science : a publication of the Protein Society 2013;22(1):65-73.
2012: Melissa S Love; Melanie G Millholland; Satish Mishra; Wenxi Pan; Mortimer Poncz; Richard W Scott; Photini Sinnis; Dewight R Williams; Lawrence W Bergman; Michael J Costanzo; Thomas M Daly; William F DeGrado; Katie B Freeman; Hyunil Jo; Robert W Kavash; M Anna Kowalska; Swapnil Kulkarni; Doron C Greenbaum
Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials.
Cell host & microbe 2012;12(6):815-23.
2012: Mei Hong; William F DeGrado
Structural basis for proton conduction and inhibition by the influenza M2 protein.
Protein science : a publication of the Protein Society 2012;21(11):1620-33.
2012: Hyunil Jo; Swapnil Kulkarni; Kristin E Low; Nataline Meinhardt; Yibing Wu; Peter L Davies; William F DeGrado; Xiaozhen Hu; Doron C Greenbaum
Development of α-helical calpain probes by mimicking a natural protein-protein interaction.
Journal of the American Chemical Society 2012;134(42):17704-13.
2012: Robert M Culik; William F DeGrado; Hyunil Jo; Feng Gai
Using thioamides to site-specifically interrogate the dynamics of hydrogen bond formation in β-sheet folding.
Journal of the American Chemical Society 2012;134(19):8026-9.
2012: Chaim A Schramm; Jeffery G Saven; William F DeGrado; Jason E Donald; Brett T Hannigan; Chen Keasar; Ilan Samish
Knowledge-based potential for positioning membrane-associated structures and assessing residue-specific energetic contributions.
Structure (London, England : 1993) 2012;20(5):924-35.
2012: Christopher J Lanci; Christopher M MacDermaid; Benjamin North; X Jade Qiu; Rudresh Acharya; William F DeGrado; Seung-gu Kang; Xi Yang; Jeffery G Saven
Computational design of a protein crystal.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(19):7304-9.
2012: David T Moore; Patrik Nygren; Joel S Bennett; Kathleen Boesze-Battaglia; Hyunil Jo; William F DeGrado
Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(3):793-8.
2011: Cinque S Soto; Brett T Hannigan; William F DeGrado
A photon-free approach to transmembrane protein structure determination.
Journal of molecular biology 2011;414(4):596-610.
2011: Bruk Mensa; Richard Scott; Gregory A Caputo; Sungwook Choi; Yong Ho Kim; William F DeGrado
Antibacterial mechanism of action of arylamide foldamers.
Antimicrobial agents and chemotherapy 2011;55(11):5043-53.
2011: Jun Wang; Yibing Wu; Robert A Lamb; Chunlong Ma; Lawrence H Pinto; William F DeGrado
Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel.
Journal of the American Chemical Society 2011;133(35):13844-7.
2011: Scott Shandler; Kathryn B Smith-Dupont; Craig N Streu; Joel S Bennett; Paul C Billings; Feng Gai; Ivan V Korendovych; Rustem I Litvinov; David T Moore; William F DeGrado
Computational design of a β-peptide that targets transmembrane helices.
Journal of the American Chemical Society 2011;133(32):12378-81.
2011: Jun Wang; Tuo Wang; Vincenzo Carnevale; Giacomo Fiorin; Mei Hong; Fanghao Hu; Michael L Klein; Robert A Lamb; Chunlong Ma; Lawrence H Pinto; William F DeGrado
Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.
Journal of the American Chemical Society 2011;133(32):12834-41.
2011: Ivan V Korendovych; Geronda L Montalvo; Scott Shandler; William F DeGrado
Environment- and sequence-dependence of helical type in membrane-spanning peptides composed of β3-amino acids.
Organic letters 2011;13(13):3474-7.
2011: Gevorg Grigoryan; David T Moore; William F DeGrado
Transmembrane communication: general principles and lessons from the structure and function of the M2 proton channel, K⁺ channels, and integrin receptors.
Annual review of biochemistry 2011;80():211-37.
2011: Amanda Remorino; Ivan V Korendovych; Yibing Wu; William F DeGrado; Robin M Hochstrasser
Residue-specific vibrational echoes yield 3D structures of a transmembrane helix dimer.
Science (New York, N.Y.) 2011;332(6034):1206-9.
2011: Gevorg Grigoryan; Yong Ho Kim; Rudresh Acharya; Kevin Axelrod; Rishabh M Jain; Lauren Willis; Marija Drndic; James M Kikkawa; William F DeGrado
Computational design of virus-like protein assemblies on carbon nanotube surfaces.
Science (New York, N.Y.) 2011;332(6033):1071-6.
2011: Ivan V Korendovych; Daniel W Kulp; Yibing Wu; Hong Cheng; Heinrich Roder; William F DeGrado
Design of a switchable eliminase.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(17):6823-7.
2011: Ayanjeet Ghosh; Jade Qiu; William F DeGrado; Robin M Hochstrasser
Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(15):6115-20.
2011: Julie M G Rogers; Alexei L Polishchuk; Lin Guo; Jun Wang; William F DeGrado; Feng Gai
Photoinduced electron transfer and fluorophore motion as a probe of the conformational dynamics of membrane proteins: application to the influenza a M2 proton channel.
Langmuir : the ACS journal of surfaces and colloids 2011;27(7):3815-21.
2011: Sarah D Cady; Jun Wang; Yibing Wu; William F DeGrado; Mei Hong
Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy.
Journal of the American Chemical Society 2011;133(12):4274-84.
2011: Jason E Donald; Yao Zhang; Giacomo Fiorin; Vincenzo Carnevale; David R Slochower; Feng Gai; Michael L Klein; William F DeGrado
Transmembrane orientation and possible role of the fusogenic peptide from parainfluenza virus 5 (PIV5) in promoting fusion.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(10):3958-63.
2011: Jason E Donald; Daniel W Kulp; William F DeGrado
Salt bridges: geometrically specific, designable interactions.
Proteins 2011;79(3):898-915.
2011: Saumen Chakraborty; Joslyn Yudenfreund Kravitz; Peter W Thulstrup; Lars Hemmingsen; William F DeGrado; Vincent L Pecoraro
Design of a three-helix bundle capable of binding heavy metals in a triscysteine environment.
Angewandte Chemie (International ed. in English) 2011;50(9):2049-53.
2011: Jun Wang; Jade Xiaoyan Qiu; Cinque Soto; William F DeGrado
Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus.
Current opinion in structural biology 2011;21(1):68-80.
2011: Gevorg Grigoryan; William F DeGrado
Probing designability via a generalized model of helical bundle geometry.
Journal of molecular biology 2011;405(4):1079-100.
2010: Douglas G Metcalf; David T Moore; Yibing Wu; Joseph M Kielec; Kathleen Molnar; Kathleen G Valentine; A Joshua Wand; Joel S Bennett; William F DeGrado
NMR analysis of the alphaIIb beta3 cytoplasmic interaction suggests a mechanism for integrin regulation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(52):22481-6.
2010: Hyunil Jo; Robert M Culik; Ivan V Korendovych; William F DeGrado; Feng Gai
Selective incorporation of nitrile-based infrared probes into proteins via cysteine alkylation.
Biochemistry 2010;49(49):10354-6.
2010: Alexei L Polishchuk; James D Lear; Chunlong Ma; Robert A Lamb; Lawrence H Pinto; William F DeGrado
A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein.
Biochemistry 2010;49(47):10061-71.
2010: Ivan V Korendovych; Yong Ho Kim; Andrew H Ryan; James D Lear; William F DeGrado; Scott Shandler
Computational design of a self-assembling β-peptide oligomer.
Organic letters 2010;12(22):5142-5.
2010: Ivan V Korendovych; Alessandro Senes; Yong Ho Kim; James D Lear; H Christopher Fry; Michael J Therien; J Kent Blasie; F Ann Walker; William F DeGrado
De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex.
Journal of the American Chemical Society 2010;132(44):15516-8.
2010: Wai Leung Lau; William F DeGrado; Heinrich Roder
The effects of pK(a) tuning on the thermodynamics and kinetics of folding: design of a solvent-shielded carboxylate pair at the a-position of a coiled-coil.
Biophysical journal 2010;99(7):2299-308.
2010: Hua Zhu; Douglas G Metcalf; Craig N Streu; Paul C Billings; William F DeGrado; Joel S Bennett
Specificity for homooligomer versus heterooligomer formation in integrin transmembrane helices.
Journal of molecular biology 2010;401(5):882-91.
2010: Edinson Lucumi; Claire Darling; Hyunil Jo; Andrew D Napper; Rajesh Chandramohanadas; Nicholas Fisher; Alison E Shone; Huiyan Jing; Stephen A Ward; Giancarlo A Biagini; William F DeGrado; Scott L Diamond; Doron C Greenbaum
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.
Antimicrobial agents and chemotherapy 2010;54(9):3597-604.
2010: Rudresh Acharya; Vincenzo Carnevale; Giacomo Fiorin; Benjamin G Levine; Alexei L Polishchuk; Victoria Balannik; Ilan Samish; Robert A Lamb; Lawrence H Pinto; William F DeGrado; Michael L Klein
Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(34):15075-80.
2010: Yongchao Su; William F DeGrado; Mei Hong
Orientation, dynamics, and lipid interaction of an antimicrobial arylamide investigated by 19F and 31P solid-state NMR spectroscopy.
Journal of the American Chemical Society 2010;132(26):9197-205.
2010: Shalom D Goldberg; Graham D Clinthorne; Mark Goulian; William F DeGrado
Transmembrane polar interactions are required for signaling in the Escherichia coli sensor kinase PhoQ.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(18):8141-6.
2010: H Christopher Fry; Andreas Lehmann; Jeffery G Saven; William F DeGrado; Michael J Therien
Computational design and elaboration of a de novo heterotetrameric alpha-helical protein that selectively binds an emissive abiological (porphinato)zinc chromophore.
Journal of the American Chemical Society 2010;132(11):3997-4005.
2010: Victoria Balannik; Petr Obrdlik; Samsoon Inayat; Catrin Steensen; Jun Wang; Joshua M Rausch; William F DeGrado; Bela Kelety; Lawrence H Pinto
Solid-supported membrane technology for the investigation of the influenza A virus M2 channel activity.
Pflügers Archiv : European journal of physiology 2010;459(4):593-605.
2010: Sarah D Cady; Klaus Schmidt-Rohr; Jun Wang; Cinque S Soto; William F DeGrado; Mei Hong
Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers.
Nature 2010;463(7281):689-92.
2010: Victoria Balannik; Vincenzo Carnevale; Giacomo Fiorin; Benjamin G Levine; Robert A Lamb; Michael L Klein; William F DeGrado; Lawrence H Pinto
Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel.
Biochemistry 2010;49(4):696-708.
2010: Gregory N Tew; Richard W Scott; Michael L Klein; William F DeGrado
De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications.
Accounts of chemical research 2010;43(1):30-9.
2010: Bryan W Berger; Daniel W Kulp; Lisa M Span; Jessica L DeGrado; Paul C Billings; Alessandro Senes; Joel S Bennett; William F DeGrado
Consensus motif for integrin transmembrane helix association.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):703-8.
2009: Victoria Balannik; Jun Wang; Yuki Ohigashi; Xianghong Jing; Emma Magavern; Robert A Lamb; William F DeGrado; Lawrence H Pinto
Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus.
Biochemistry 2009;48(50):11872-82.
2009: Marina Faiella; Concetta Andreozzi; Rafael Torres Martin de Rosales; Vincenzo Pavone; Ornella Maglio; Flavia Nastri; William F DeGrado; Angela Lombardi
An artificial di-iron oxo-protein with phenol oxidase activity.
Nature chemical biology 2009;5(12):882-4.
2009: Douglas G Metcalf; Dan W Kulp; Joel S Bennett; William F DeGrado
Multiple approaches converge on the structure of the integrin alphaIIb/beta3 transmembrane heterodimer.
Journal of molecular biology 2009;392(4):1087-101.
2009: Fanglian He; Gauri R Nair; Cinque S Soto; Yehchung Chang; Lillian Hsu; Erik Ronzone; William F DeGrado; Andrew N Binns
Molecular basis of ChvE function in sugar binding, sugar utilization, and virulence in Agrobacterium tumefaciens.
Journal of bacteriology 2009;191(18):5802-13.
2009: Yao Zhang; Daniel W Kulp; James D Lear; William F DeGrado
Experimental and computational evaluation of forces directing the association of transmembrane helices.
Journal of the American Chemical Society 2009;131(32):11341-3.
2009: Chunlong Ma; Alexei L Polishchuk; Yuki Ohigashi; Amanda L Stouffer; Arne Schön; Emma Magavern; Xianghong Jing; James D Lear; Ernesto Freire; Robert A Lamb; William F DeGrado; Lawrence H Pinto
Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12283-8.
2009: Jun Wang; Sarah D Cady; Victoria Balannik; Lawrence H Pinto; William F DeGrado; Mei Hong
Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus.
Journal of the American Chemical Society 2009;131(23):8066-76.
2009: Sungwook Choi; Andre Isaacs; Dylan Clements; Dahui Liu; Hyemin Kim; Richard W Scott; Jeffrey D Winkler; William F DeGrado
De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):6968-73.
2009: Jia Tang; Hang Yin; Jade Qiu; Matthew J Tucker; William F DeGrado; Feng Gai
Using two fluorescent probes to dissect the binding, insertion, and dimerization kinetics of a model membrane peptide.
Journal of the American Chemical Society 2009;131(11):3816-7.
2009: Rachel S Signarvic; William F DeGrado
Metal-binding dependent disruption of membranes by designed helices.
Journal of the American Chemical Society 2009;131(9):3377-84.
2009: Mei Lin Z Bissonnette; Jason E Donald; William F DeGrado; Theodore S Jardetzky; Robert A Lamb
Functional analysis of the transmembrane domain in paramyxovirus F protein-mediated membrane fusion.
Journal of molecular biology 2009;386(1):14-36.
2009: Ekta Khurana; Matteo Dal Peraro; Russell DeVane; Satyavani Vemparala; William F DeGrado; Michael L Klein
Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(4):1069-74.
2009: Meredith W Miller; Sandeep Basra; Daniel W Kulp; Paul C Billings; Sungwook Choi; Mary Pat Beavers; Owen J T McCarty; Zhiying Zou; Mark L Kahn; Joel S Bennett; William F DeGrado
Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):719-24.
2009: Shalom D Goldberg; Paige Derr; William F DeGrado; Mark Goulian
Engineered single- and multi-cell chemotaxis pathways in E. coli.
Molecular systems biology 2009;5():283.
2009: Kenichi Kuroda; Gregory A Caputo; William F DeGrado
The role of hydrophobicity in the antimicrobial and hemolytic activities of polymethacrylate derivatives.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(5):1123-33.
2008: Richard W Scott; William F DeGrado; Gregory N Tew
De novo designed synthetic mimics of antimicrobial peptides.
Current opinion in biotechnology 2008;19(6):620-7.
2008: Phuong A Nguyen; Cinque S Soto; Alexei Polishchuk; Gregory A Caputo; Chad D Tatko; Chunlong Ma; Yuki Ohigashi; Lawrence H Pinto; William F DeGrado; Kathleen P Howard
pH-induced conformational change of the influenza M2 protein C-terminal domain.
Biochemistry 2008;47(38):9934-6.
2008: Karen A McAllister; Hongling Zou; Frank V Cochran; Gretchen M Bender; Alessandro Senes; H Christopher Fry; Vikas Nanda; Patricia A Keenan; James D Lear; Jeffery G Saven; Michael J Therien; J Kent Blasie; William F DeGrado
Using alpha-helical coiled-coils to design nanostructured metalloporphyrin arrays.
Journal of the American Chemical Society 2008;130(36):11921-7.
2008: Gregory A Caputo; Rustem I Litvinov; Wei Li; Joel S Bennett; William F DeGrado; Hang Yin
Computationally designed peptide inhibitors of protein-protein interactions in membranes.
Biochemistry 2008;47(33):8600-6.
2008: Jennifer R Calhoun; Caleb B Bell; Thomas J Smith; Thomas J Thamann; William F DeGrado; Edward I Solomon
Oxygen reactivity of the biferrous site in the de novo designed four helix bundle peptide DFsc: nature of the "intermediate" and reaction mechanism.
Journal of the American Chemical Society 2008;130(29):9188-9.
2008: Amanda L Stouffer; Chunlong Ma; Lidia Cristian; Yuki Ohigashi; Robert A Lamb; James D Lear; Lawrence H Pinto; William F DeGrado
The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus.
Structure (London, England : 1993) 2008;16(7):1067-76.
2008: David T Moore; Bryan W Berger; William F DeGrado
Protein-protein interactions in the membrane: sequence, structural, and biological motifs.
Structure (London, England : 1993) 2008;16(7):991-1001.
2008: Shalom D Goldberg; Cinque S Soto; Carey D Waldburger; William F DeGrado
Determination of the physiological dimer interface of the PhoQ sensor domain.
Journal of molecular biology 2008;379(4):656-65.
2008: Chunlong Ma; Cinque S Soto; Yuki Ohigashi; Albert Taylor; Vasilios Bournas; Brett Glawe; Maria K Udo; William F DeGrado; Robert A Lamb; Lawrence H Pinto
Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus.
The Journal of biological chemistry 2008;283(23):15921-31.
2008: Jennifer R Calhoun; Weixia Liu; Katrin Spiegel; Matteo Dal Peraro; Michael L Klein; Kathleen G Valentine; A Joshua Wand; William F DeGrado
Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement.
Structure (London, England : 1993) 2008;16(2):210-5.
2008: Amanda L Stouffer; Rudresh Acharya; David Salom; Anna S Levine; Luigi Di Costanzo; Cinque S Soto; Valentina Tereshko; Vikas Nanda; Steven Stayrook; William F DeGrado
Structural basis for the function and inhibition of an influenza virus proton channel.
Nature 2008;451(7178):596-9.
2007: Jia Tang; Rachel S Signarvic; William F DeGrado; Feng Gai
Role of helix nucleation in the kinetics of binding of mastoparan X to phospholipid bilayers.
Biochemistry 2007;46(48):13856-63.
2007: Sungwook Choi; Gaston Vilaire; Cezary Marcinkiewicz; Jeffrey D Winkler; Joel S Bennett; William F DeGrado
Small molecule inhibitors of integrin alpha2beta1.
Journal of medicinal chemistry 2007;50(22):5457-62.
2007: Gurusamy Balakrishnan; Ying Hu; Gretchen M Bender; Zelleka Getahun; William F DeGrado; Thomas G Spiro
Enthalpic and entropic stages in alpha-helical peptide unfolding, from laser T-jump/UV Raman spectroscopy.
Journal of the American Chemical Society 2007;129(42):12801-8.
2007: Smita Mukherjee; Pramit Chowdhury; William F DeGrado; Feng Gai
Site-specific hydration status of an amphipathic peptide in AOT reverse micelles.
Langmuir : the ACS journal of surfaces and colloids 2007;23(22):11174-9.
2007: Gretchen M Bender; Andreas Lehmann; Hongling Zou; Hong Cheng; H Christopher Fry; Donald E Engel; Michael J Therien; J Kent Blasie; Heinrich Roder; Jeffery G Saven; William F DeGrado
De novo design of a single-chain diphenylporphyrin metalloprotein.
Journal of the American Chemical Society 2007;129(35):10732-40.
2007: Olga S Finikova; Thomas Troxler; Alessandro Senes; William F DeGrado; Robin M Hochstrasser; Sergei A Vinogradov
Energy and electron transfer in enhanced two-photon-absorbing systems with triplet cores.
The journal of physical chemistry. A 2007;111(30):6977-90.
2007: Pen-Cheng Wang; Gaston Vilaire; William F DeGrado; Joel S Bennett
Interactions of ADP-stimulated human platelets with PEGylated polystyrene substrates prepared by surface amidation.
Colloids and surfaces. B, Biointerfaces 2007;58(2):225-30.
2007: Sarah D Cady; Catherine Goodman; Chad D Tatko; William F DeGrado; Mei Hong
Determining the orientation of uniaxially rotating membrane proteins using unoriented samples: a 2H, 13C, AND 15N solid-state NMR investigation of the dynamics and orientation of a transmembrane helical bundle.
Journal of the American Chemical Society 2007;129(17):5719-29.
2007: Catherine M Goodman; Sungwook Choi; Scott Shandler; William F DeGrado
Foldamers as versatile frameworks for the design and evolution of function.
Nature chemical biology 2007;3(5):252-62.
2007: Douglas G Metcalf; Peter B Law; William F DeGrado
Mutagenesis data in the automated prediction of transmembrane helix dimers.
Proteins 2007;67(2):375-84.
2007: Mark H Lee; Christopher Sean Adams; David Boettiger; William F DeGrado; Irving M Shapiro; Russell J Composto; Paul Ducheyne
Adhesion of MC3T3-E1 cells to RGD peptides of different flanking residues: detachment strength and correlation with long-term cellular function.
Journal of biomedical materials research. Part A 2007;81(1):150-60.
2007: Hang Yin; Joanna S Slusky; Bryan W Berger; Robin S Walters; Gaston Vilaire; Rustem I Litvinov; James D Lear; Gregory A Caputo; Joel S Bennett; William F DeGrado
Computational design of peptides that target transmembrane helices.
Science (New York, N.Y.) 2007;315(5820):1817-22.
2007: Matteo Dal Peraro; Katrin Spiegel; Guillaume Lamoureux; Marco De Vivo; William F DeGrado; Michael L Klein
Modeling the charge distribution at metal sites in proteins for molecular dynamics simulations.
Journal of structural biology 2007;157(3):444-53.
2007: Alessandro Senes; Deborah C Chadi; Peter B Law; Robin F S Walters; Vikas Nanda; William F DeGrado
E(z), a depth-dependent potential for assessing the energies of insertion of amino acid side-chains into membranes: derivation and applications to determining the orientation of transmembrane and interfacial helices.
Journal of molecular biology 2007;366(2):436-48.
2006: Hang Yin; Rustem I Litvinov; Gaston Vilaire; Hua Zhu; Wei Li; Gregory A Caputo; David T Moore; James D Lear; John W Weisel; William F DeGrado; Joel S Bennett
Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb.
The Journal of biological chemistry 2006;281(48):36732-41.
2006: Chong Fang; Alessandro Senes; Lidia Cristian; William F DeGrado; Robin M Hochstrasser
Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16740-5.
2006: R F S Walters; William F DeGrado
Helix-packing motifs in membrane proteins.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13658-63.
2006: Michelle R Bunagan; Lidia Cristian; William F DeGrado; Feng Gai
Truncation of a cross-linked GCN4-p1 coiled coil leads to ultrafast folding.
Biochemistry 2006;45(36):10981-6.
2006: HERSCHEL WADE; Steven E Stayrook; William F DeGrado
The structure of a designed diiron(III) protein: implications for cofactor stabilization and catalysis.
Angewandte Chemie (International ed. in English) 2006;45(30):4951-4.
2006: Hang Yin; Lars Ole Gerlach; Meredith W Miller; David T Moore; Dahui Liu; Gaston Vilaire; Joel S Bennett; William F DeGrado
Arylamide derivatives as allosteric inhibitors of the integrin alpha2beta1/type I collagen interaction.
Bioorganic & medicinal chemistry letters 2006;16(13):3380-2.
2006: Benjamin North; Lidia Cristian; Xiaoran Fu Stowell; James D Lear; Jeffery G Saven; William F DeGrado
Characterization of a membrane protein folding motif, the Ser zipper, using designed peptides.
Journal of molecular biology 2006;359(4):930-9.
2006: Rustem I Litvinov; Gaston Vilaire; Wei Li; William F DeGrado; John W Weisel; Joel S Bennett
Activation of individual alphaIIbbeta3 integrin molecules by disruption of transmembrane domain interactions in the absence of clustering.
Biochemistry 2006;45(15):4957-64.
2006: Chad D Tatko; Vikas Nanda; James D Lear; William F DeGrado
Polar networks control oligomeric assembly in membranes.
Journal of the American Chemical Society 2006;128(13):4170-1.
2006: Vojislava Pophristic; Satyavani Vemparala; Ivaylo Ivanov; Zhiwei Liu; Michael L Klein; William F DeGrado
Controlling the shape and flexibility of arylamides: a combined ab initio, ab initio molecular dynamics, and classical molecular dynamics study.
The journal of physical chemistry. B 2006;110(8):3517-26.
2006: Ivaylo Ivanov; Satyavani Vemparala; Vojislava Pophristic; Kenichi Kuroda; William F DeGrado; J Andrew McCammon; Michael L Klein
Characterization of nonbiological antimicrobial polymers in aqueous solution and at water-lipid interfaces from all-atom molecular dynamics.
Journal of the American Chemical Society 2006;128(6):1778-9.
2006: Hang Yin; Kendra King Frederick; Dahui Liu; A Joshua Wand; William F DeGrado
Arylamide derivatives as peptidomimetic inhibitors of calmodulin.
Organic letters 2006;8(2):223-5.
2005: Silvano Geremia; Luigi Di Costanzo; Lucio Randaccio; Donald E Engel; Angela Lombardi; Flavia Nastri; William F DeGrado
Response of a designed metalloprotein to changes in metal ion coordination, exogenous ligands, and active site volume determined by X-ray crystallography.
Journal of the American Chemical Society 2005;127(49):17266-76.
2005: Ting Wang; Wai Leung Lau; William F DeGrado; Feng Gai
T-jump infrared study of the folding mechanism of coiled-coil GCN4-p1.
Biophysical journal 2005;89(6):4180-7.
2005: Donald E Engel; William F DeGrado
Alpha-alpha linking motifs and interhelical orientations.
Proteins 2005;61(2):325-37.
2005: Sungwook Choi; Dylan J Clements; Vojislava Pophristic; Ivaylo Ivanov; Satyavani Vemparala; Joel S Bennett; Michael L Klein; Jeffrey D Winkler; William F DeGrado
The design and evaluation of heparin-binding foldamers.
Angewandte Chemie (International ed. in English) 2005;44(41):6685-9.
2005: Christopher M Summa; Michael Levitt; William F DeGrado
An atomic environment potential for use in protein structure prediction.
Journal of molecular biology 2005;352(4):986-1001.
2005: Ornella Maglio; Flavia Nastri; Jennifer R Calhoun; Stephen Lahr; HERSCHEL WADE; Vincenzo Pavone; William F DeGrado; Angela Lombardi
Artificial di-iron proteins: solution characterization of four helix bundles containing two distinct types of inter-helical loops.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2005;10(5):539-49.
2005: P Jeanene Willcox; Cynthia A Reinhart-King; Steven J Lahr; William F DeGrado; Daniel A Hammer
Dynamic heterodimer-functionalized surfaces for endothelial cell adhesion.
Biomaterials 2005;26(23):4757-66.
2005: Lidia Cristian; Vikas Nanda; James D Lear; William F DeGrado
Synergistic interactions between aqueous and membrane domains of a designed protein determine its fold and stability.
Journal of molecular biology 2005;348(5):1225-33.
2005: Vikas Nanda; William F DeGrado
Automated use of mutagenesis data in structure prediction.
Proteins 2005;59(3):454-66.
2005: Avram M Slovic; Steven E Stayrook; Benjamin North; William F DeGrado
X-ray structure of a water-soluble analog of the membrane protein phospholamban: sequence determinants defining the topology of tetrameric and pentameric coiled coils.
Journal of molecular biology 2005;348(3):777-87.
2005: Vikas Nanda; Michael M Rosenblatt; Artur Osyczka; Hidetoshi Kono; Zelleka Getahun; P Leslie Dutton; Jeffery G Saven; William F DeGrado
De novo design of a redox-active minimal rubredoxin mimic.
Journal of the American Chemical Society 2005;127(16):5804-5.
2005: Kenichi Kuroda; William F DeGrado
Amphiphilic polymethacrylate derivatives as antimicrobial agents.
Journal of the American Chemical Society 2005;127(12):4128-9.
2005: Amanda L Stouffer; Vikas Nanda; James D Lear; William F DeGrado
Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function.
Journal of molecular biology 2005;347(1):169-79.
2005: Steven J Lahr; Donald E Engel; Steven E Stayrook; Ornella Maglio; Benjamin North; Silvano Geremia; Angela Lombardi; William F DeGrado
Analysis and design of turns in alpha-helical hairpins.
Journal of molecular biology 2005;346(5):1441-54.
2005: Avram M Slovic; James D Lear; William F DeGrado
De novo design of a pentameric coiled-coil: decoding the motif for tetramer versus pentamer formation in water-soluble phospholamban.
The journal of peptide research : official journal of the American Peptide Society 2005;65(3):312-21.
2005: Frank V Cochran; Sophia P Wu; Wei Wang; Vikas Nanda; Jeffery G Saven; Michael J Therien; William F DeGrado
Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor.
Journal of the American Chemical Society 2005;127(5):1346-7.
2005: Wei Li; Douglas G Metcalf; Roman Gorelik; Renhao Li; Neal Mitra; Vikas Nanda; Peter B Law; James D Lear; William F DeGrado; Joel S Bennett
A push-pull mechanism for regulating integrin function.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1424-9.
2005: Jennifer R Calhoun; Flavia Nastri; Ornella Maglio; Vincenzo Pavone; Angela Lombardi; William F DeGrado
Artificial diiron proteins: from structure to function.
Biopolymers 2005;80(2-3):264-78.
2004: Giovanna Ghirlanda; Simon A Hilcove; Ravindernath Pidikiti; Jonas S Johansson; James D Lear; William F DeGrado; Roderic G Eckenhoff
Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide.
FEBS letters 2004;578(1-2):140-4.
2004: Vikas Nanda; William F DeGrado
Simulated evolution of emergent chiral structures in polyalanine.
Journal of the American Chemical Society 2004;126(44):14459-67.
2004: James D Lear; Amanda L Stouffer; Holly Gratkowski; Vikas Nanda; William F DeGrado
Association of a model transmembrane peptide containing gly in a heptad sequence motif.
Biophysical journal 2004;87(5):3421-9.
2004: Robert J Doerksen; Bin Chen; Dahui Liu; Gregory N Tew; William F DeGrado; Michael L Klein
Controlling the conformation of arylamides: computational studies of intramolecular hydrogen bonds between amides and ethers or thioethers.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(20):5008-16.
2004: J Kaplan; William F DeGrado
De novo design of catalytic proteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11566-70.
2004: Alessandro Senes; Donald E Engel; William F DeGrado
Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs.
Current opinion in structural biology 2004;14(4):465-79.
2004: Giovanna Ghirlanda; Artur Osyczka; Weixia Liu; Michael Antolovich; Kevin M Smith; P Leslie Dutton; A Joshua Wand; William F DeGrado
De novo design of a D2-symmetrical protein that reproduces the diheme four-helix bundle in cytochrome bc1.
Journal of the American Chemical Society 2004;126(26):8141-7.
2004: Renhao Li; Roman Gorelik; Vikas Nanda; Peter B Law; James D Lear; William F DeGrado; Joel S Bennett
Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes.
The Journal of biological chemistry 2004;279(25):26666-73.
2004: R Li; J S Bennett; William F DeGrado
Structural basis for integrin alphaIIbbeta3 clustering.
Biochemical Society transactions 2004;32(Pt3):412-5.
2004: Matthew J Tucker; Zelleka Getahun; Vikas Nanda; William F DeGrado; Feng Gai
A new method for determining the local environment and orientation of individual side chains of membrane-binding peptides.
Journal of the American Chemical Society 2004;126(16):5078-9.
2004: Donald E Engel; William F DeGrado
Amino acid propensities are position-dependent throughout the length of alpha-helices.
Journal of molecular biology 2004;337(5):1195-205.
2004: Dahui Liu; Sungwook Choi; Bin Chen; Robert J Doerksen; Dylan J Clements; Jeffrey D Winkler; Michael L Klein; William F DeGrado
Nontoxic membrane-active antimicrobial arylamide oligomers.
Angewandte Chemie (International ed. in English) 2004;43(9):1158-62.
2004: Avram M Slovic; Hidetoshi Kono; James D Lear; Jeffery G Saven; William F DeGrado
Computational design of water-soluble analogues of the potassium channel KcsA.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1828-33.
2004: Wai Leung Lau; David S Ege; James D Lear; Daniel A Hammer; William F DeGrado
Oligomerization of fusogenic peptides promotes membrane fusion by enhancing membrane destabilization.
Biophysical journal 2004;86(1 Pt 1):272-84.
2003: Yongjin Zhu; Darwin O V Alonso; Kosuke Maki; Cheng-Yen Huang; Steven J Lahr; Valerie Daggett; Heinrich Roder; William F DeGrado; Feng Gai
Ultrafast folding of alpha3D: a de novo designed three-helix bundle protein.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15486-91.
2003: Jennifer R Calhoun; Hidetoshi Kono; Steven J Lahr; Wei Wang; William F DeGrado; Jeffery G Saven
Computational design and characterization of a monomeric helical dinuclear metalloprotein.
Journal of molecular biology 2003;334(5):1101-15.
2003: Lidia Cristian; James D Lear; William F DeGrado
Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14772-7.
2003: Rachel S Signarvic; William F DeGrado
De novo design of a molecular switch: phosphorylation-dependent association of designed peptides.
Journal of molecular biology 2003;334(1):1-12.
2003: Lidia Cristian; James D Lear; William F DeGrado
Determination of membrane protein stability via thermodynamic coupling of folding to thiol-disulfide interchange.
Protein science : a publication of the Protein Society 2003;12(8):1732-40.
2003: James D Lear; Holly Gratkowski; Larisa Adamian; Jie Liang; William F DeGrado
Position-dependence of stabilizing polar interactions of asparagine in transmembrane helical bundles.
Biochemistry 2003;42(21):6400-7.
2003: Renhao Li; Neal Mitra; Holly Gratkowski; Gaston Vilaire; Rustem I Litvinov; Chandrasekaran Nagasami; John W Weisel; James D Lear; William F DeGrado; Joel S Bennett
Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations.
Science (New York, N.Y.) 2003;300(5620):795-8.
2003: Ornella Maglio; Flavia Nastri; Vincenzo Pavone; Angela Lombardi; William F DeGrado
Preorganization of molecular binding sites in designed diiron proteins.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):3772-7.
2003: William F DeGrado; Holly Gratkowski; James D Lear
How do helix-helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundles.
Protein science : a publication of the Protein Society 2003;12(4):647-65.
2003: Scott T R Walsh; Richard P Cheng; Wayne W Wright; Darwin O V Alonso; Valerie Daggett; Jane M Vanderkooi; William F DeGrado
The hydration of amides in helices; a comprehensive picture from molecular dynamics, IR, and NMR.
Protein science : a publication of the Protein Society 2003;12(3):520-31.
2003: Avram M Slovic; Christopher M Summa; James D Lear; William F DeGrado
Computational design of a water-soluble analog of phospholamban.
Protein science : a publication of the Protein Society 2003;12(2):337-48.
2003: William F DeGrado; Luigi Di Costanzo; Silvano Geremia; Angela Lombardi; Vincenzo Pavone; Lucio Randaccio
Sliding helix and change of coordination geometry in a model di-MnII protein.
Angewandte Chemie (International ed. in English) 2003;42(4):417-20.
2003: Zelleka Getahun; Cheng-Yen Huang; Ting Wang; Brenda De León; William F DeGrado; Feng Gai
Using nitrile-derivatized amino acids as infrared probes of local environment.
Journal of the American Chemical Society 2003;125(2):405-11.
2003: Renhao Li; Ronald H Hoess; Joel S Bennett; William F DeGrado
Use of phage display to probe the evolution of binding specificity and affinity in integrins.
Protein engineering 2003;16(1):65-72.
2002: Renhao Li; Charles R Babu; Kathleen G Valentine; James D Lear; A Joshua Wand; Joel S Bennett; William F DeGrado
Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy.
Biochemistry 2002;41(52):15618-24.
2002: Cheng-Yen Huang; Shu He; William F DeGrado; Dewey G McCafferty; Feng Gai
Light-induced helix formation.
Journal of the American Chemical Society 2002;124(43):12674-5.
2002: Richard P Cheng; William F DeGrado
Long-range interactions stabilize the fold of a non-natural oligomer.
Journal of the American Chemical Society 2002;124(39):11564-5.
2002: Holly Gratkowski; Qing-Hong Dai; A Joshua Wand; William F DeGrado; James D Lear
Cooperativity and specificity of association of a designed transmembrane peptide.
Biophysical journal 2002;83(3):1613-9.
2002: Christopher M Summa; Michael M Rosenblatt; Jae-Kyoung Hong; James D Lear; William F DeGrado
Computational de novo design, and characterization of an A(2)B(2) diiron protein.
Journal of molecular biology 2002;321(5):923-38.
2002: Giovanna Ghirlanda; James D Lear; Nancy L Ogihara; David Eisenberg; William F DeGrado
A hierarchic approach to the design of hexameric helical barrels.
Journal of molecular biology 2002;319(1):243-53.
2002: E Neil Marsh; William F DeGrado
Noncovalent self-assembly of a heterotetrameric diiron protein.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5150-4.
2002: Gregory N Tew; Dahui Liu; Bin Chen; Robert J Doerksen; Justin Kaplan; Patrick J Carroll; Michael L Klein; William F DeGrado
De novo design of biomimetic antimicrobial polymers.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5110-4.
2002: Cheng-Yen Huang; Zelleka Getahun; Yongjin Zhu; Jason W Klemke; William F DeGrado; Feng Gai
Helix formation via conformation diffusion search.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2788-93.
2001: Luigi Di Costanzo; HERSCHEL WADE; Silvano Geremia; Lucio Randaccio; Vincenzo Pavone; William F DeGrado; Angela Lombardi
Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center.
Journal of the American Chemical Society 2001;123(51):12749-57.
2001: Richard P Cheng; D J Suich; Hong Cheng; Heinrich Roder; William F DeGrado
Template-constrained somatostatin analogues: a biphenyl linker induces a type-V' turn.
Journal of the American Chemical Society 2001;123(50):12710-1.
2001: Cheng-Yen Huang; Zelleka Getahun; Ting Wang; William F DeGrado; Feng Gai
Time-resolved infrared study of the helix-coil transition using (13)C-labeled helical peptides.
Journal of the American Chemical Society 2001;123(48):12111-2.
2001: Renhao Li; Charles R Babu; James D Lear; A Joshua Wand; Joel S Bennett; William F DeGrado
Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12462-7.
2001: Richard P Cheng; S H Gellman; William F DeGrado
beta-Peptides: from structure to function.
Chemical reviews 2001;101(10):3219-32.
2001: Cheng-Yen Huang; Jason W Klemke; Zelleka Getahun; William F DeGrado; Feng Gai
Temperature-dependent helix-coil transition of an alanine based peptide.
Journal of the American Chemical Society 2001;123(38):9235-8.
2001: Benjamin North; Christopher M Summa; Giovanna Ghirlanda; William F DeGrado
D(n)-symmetrical tertiary templates for the design of tubular proteins.
Journal of molecular biology 2001;311(5):1081-90.
2001: Scott T R Walsh; Andrew L Lee; William F DeGrado; A Joshua Wand
Dynamics of a de novo designed three-helix bundle protein studied by 15N, 13C, and 2H NMR relaxation methods.
Biochemistry 2001;40(32):9560-9.
2001: Dahui Liu; William F DeGrado
De novo design, synthesis, and characterization of antimicrobial beta-peptides.
Journal of the American Chemical Society 2001;123(31):7553-9.
2001: James D Lear; Holly Gratkowski; William F DeGrado
De novo design, synthesis and characterization of membrane-active peptides.
Biochemical Society transactions 2001;29(Pt 4):559-64.
2001: Richard P Cheng; William F DeGrado
De novo design of a monomeric helical beta-peptide stabilized by electrostatic interactions.
Journal of the American Chemical Society 2001;123(21):5162-3.
2001: A Pasternak; J Kaplan; James D Lear; William F DeGrado
Proton and metal ion-dependent assembly of a model diiron protein.
Protein science : a publication of the Protein Society 2001;10(5):958-69.
2001: Nancy L Ogihara; G Ghirlanda; J W Bryson; Mari Gingery; William F DeGrado; David Eisenberg
Design of three-dimensional domain-swapped dimers and fibrous oligomers.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1404-9.
2001: Holly Gratkowski; James D Lear; William F DeGrado
Polar side chains drive the association of model transmembrane peptides.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):880-5.
2001: Scott T R Walsh; VI Sukharev; S F Betz; NL Vekshin; William F DeGrado
Hydrophobic core malleability of a de novo designed three-helix bundle protein.
Journal of molecular biology 2001;305(2):361-73.
2000: David S Talaga; Wai Leung Lau; Heinrich Roder; J Tang; Y Jia; William F DeGrado; Robin M Hochstrasser
Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(24):13021-6.
2000: D Salom; B R Hill; James D Lear; William F DeGrado
pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus.
Biochemistry 2000;39(46):14160-70.
2000: K T O'Neil; A C Bach; William F DeGrado
Structural consequences of an amino acid deletion in the B1 domain of protein G.
Proteins 2000;41(3):323-33.
2000: D J Suich; Shaker A Mousa; G Singh; G Liapakis; Terry Reisine; William F DeGrado
Template-constrained cyclic peptide analogues of somatostatin: subtype-selective binding to somatostatin receptors and antiangiogenic activity.
Bioorganic & medicinal chemistry 2000;8(9):2229-41.
2000: O Helluin; C Chan; Gaston Vilaire; Shaker A Mousa; William F DeGrado; Joel S Bennett
The activation state of alphavbeta 3 regulates platelet and lymphocyte adhesion to intact and thrombin-cleaved osteopontin.
The Journal of biological chemistry 2000;275(24):18337-43.
2000: Angela Lombardi; C M Summa; Silvano Geremia; Lucio Randaccio; Vincenzo Pavone; William F DeGrado
Retrostructural analysis of metalloproteins: application to the design of a minimal model for diiron proteins.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6298-305.
2000: C Choma; Holly Gratkowski; James D Lear; William F DeGrado
Asparagine-mediated self-association of a model transmembrane helix.
Nature structural biology 2000;7(2):161-6.
1999: William F DeGrado; J P Schneider; Yoshitomo Hamuro
The twists and turns of beta-peptides.
The journal of peptide research : official journal of the American Peptide Society 1999;54(3):206-17.
1999: Christopher M Summa; Angela Lombardi; Mitchell Lewis; William F DeGrado
Tertiary templates for the design of diiron proteins.
Current opinion in structural biology 1999;9(4):500-8.
1999: W R Patterson; Daniel H Anderson; William F DeGrado; Duilio Cascio; David Eisenberg
Centrosymmetric bilayers in the 0.75 A resolution structure of a designed alpha-helical peptide, D,L-Alpha-1.
Protein science : a publication of the Protein Society 1999;8(7):1410-22.
1999: Scott T R Walsh; Hong Cheng; J W Bryson; Heinrich Roder; William F DeGrado
Solution structure and dynamics of a de novo designed three-helix bundle protein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5486-91.
1999: P Hamm; M Lim; William F DeGrado; Robin M Hochstrasser
The two-dimensional IR nonlinear spectroscopy of a cyclic penta-peptide in relation to its three-dimensional structure.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2036-41.
1999: C S Gandhi; Kevin Shuck; James D Lear; GR Dieckmann; William F DeGrado; Robert A Lamb; Lawrence H Pinto
Cu(II) inhibition of the proton translocation machinery of the influenza A virus M2 protein.
The Journal of biological chemistry 1999;274(9):5474-82.
1999: GR Dieckmann; James D Lear; Q Zhong; Michael L Klein; William F DeGrado; Kim A Sharp
Exploration of the structural features defining the conduction properties of a synthetic ion channel.
Biophysical journal 1999;76(2):618-30.
1999: William F DeGrado; C M Summa; Vincenzo Pavone; Flavia Nastri; Angela Lombardi
De novo design and structural characterization of proteins and metalloproteins.
Annual review of biochemistry 1999;68():779-819.
1998: Giovanna Ghirlanda; James D Lear; Angela Lombardi; William F DeGrado
From synthetic coiled coils to functional proteins: automated design of a receptor for the calmodulin-binding domain of calcineurin.
Journal of molecular biology 1998;281(2):379-91.
1998: GR Dieckmann; don mcrorie; James D Lear; Kim A Sharp; William F DeGrado; vincent pecoraro
The role of protonation and metal chelation preferences in defining the properties of mercury-binding coiled coils.
Journal of molecular biology 1998;280(5):897-912.
1997: Lawrence H Pinto; GR Dieckmann; C S Gandhi; C G Papworth; J Braman; M A Shaughnessy; James D Lear; Robert A Lamb; William F DeGrado
A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11301-6.
1997: William F DeGrado
Proteins from scratch.
Science (New York, N.Y.) 1997;278(5335):80-1.
1997: GR Dieckmann; William F DeGrado
Modeling transmembrane helical oligomers.
Current opinion in structural biology 1997;7(4):486-94.
1997: Joel S Bennett; C Chan; Gaston Vilaire; Shaker A Mousa; William F DeGrado
Agonist-activated alphavbeta3 on platelets and lymphocytes binds to the matrix protein osteopontin.
The Journal of biological chemistry 1997;272(13):8137-40.
1997: S F Betz; Paul A Liebman; William F DeGrado
De novo design of native proteins: characterization of proteins intended to fold into antiparallel, rop-like, four-helix bundles.
Biochemistry 1997;36(9):2450-8.
1997: Nancy L Ogihara; M S Weiss; William F DeGrado; David Eisenberg
The crystal structure of the designed trimeric coiled coil coil-VaLd: implications for engineering crystals and supramolecular assemblies.
Protein science : a publication of the Protein Society 1997;6(1):80-8.